CA1012972A - 4-LITHIO-.alpha.-ISOPROPENYL-2-OXOAZETIDINE-1-ACETIC ACID COMPOUNDS - Google Patents
4-LITHIO-.alpha.-ISOPROPENYL-2-OXOAZETIDINE-1-ACETIC ACID COMPOUNDSInfo
- Publication number
- CA1012972A CA1012972A CA213,109A CA213109A CA1012972A CA 1012972 A CA1012972 A CA 1012972A CA 213109 A CA213109 A CA 213109A CA 1012972 A CA1012972 A CA 1012972A
- Authority
- CA
- Canada
- Prior art keywords
- oxoazetidine
- lithio
- isopropenyl
- alpha
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4615871A JPS5632306B1 (zh) | 1971-06-24 | 1971-06-24 | |
JP6177771A JPS5442995B2 (zh) | 1971-08-14 | 1971-08-14 | |
JP6177671A JPS557432B2 (zh) | 1971-08-14 | 1971-08-14 | |
JP6268771A JPS5442996B2 (zh) | 1971-08-18 | 1971-08-18 | |
JP46063885A JPS4829759A (zh) | 1971-08-21 | 1971-08-21 | |
JP6388671A JPS5614664B2 (zh) | 1971-08-21 | 1971-08-21 | |
JP7001871A JPS557433B2 (zh) | 1971-09-09 | 1971-09-09 | |
JP251672A JPS5438115B2 (zh) | 1971-12-23 | 1971-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1012972A true CA1012972A (en) | 1977-06-28 |
Family
ID=27571464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA213,109A Expired CA1012972A (en) | 1971-06-24 | 1974-11-04 | 4-LITHIO-.alpha.-ISOPROPENYL-2-OXOAZETIDINE-1-ACETIC ACID COMPOUNDS |
Country Status (7)
Country | Link |
---|---|
US (7) | US4009159A (zh) |
CA (1) | CA1012972A (zh) |
CH (6) | CH593293A5 (zh) |
DE (1) | DE2265798C2 (zh) |
FR (1) | FR2143211B1 (zh) |
GB (4) | GB1403004A (zh) |
NL (2) | NL7208671A (zh) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2265798C2 (de) * | 1971-06-24 | 1985-09-26 | Fujisawa Pharmaceutical Co., Ltd., Osaka | Verfahren zur Herstellung von Oxoazetidin-Derivaten |
US4267340A (en) * | 1971-06-24 | 1981-05-12 | Fujisawa Pharmaceutical Co., Ltd. | Disulfide substituted oxazetidine derivatives |
US4128714A (en) * | 1972-04-14 | 1978-12-05 | Meiji Seika Kaisha Ltd. | Process for the preparation of 7-acylamida-3-halo-3-alkyl-cepham-4-carboxylic acids and esters |
US4164497A (en) * | 1972-10-20 | 1979-08-14 | Fujisawa Pharmaceutical Co., Ltd. | 2-Substituted penam derivatives |
US4084049A (en) * | 1972-10-20 | 1978-04-11 | Fujisawa Pharmaceutical Co., Ltd. | Cepham derivatives |
JPS4970989A (zh) * | 1972-11-15 | 1974-07-09 | ||
AR208068A1 (es) * | 1973-02-23 | 1976-11-30 | Lilly Co Eli | Un procedimiento para preparar derivados de acidos 7-acilamido-3-halo-cefem-4-carboxilico los esteres y las sales farmaceuticamente aceptables de los mismos |
YU36970B (en) * | 1973-02-23 | 1984-08-31 | Lilly Co Eli | Process for obtaining 7-(amino)-acylamido-3-halocephalosporins |
US4255328A (en) * | 1974-02-26 | 1981-03-10 | Ciba-Geigy Corporation | Sulfide intermediates for the manufacture of enol derivatives |
CA1069126A (en) * | 1974-12-24 | 1980-01-01 | Eli Lilly And Company | Sulfinyl halides and their preparation from penicillin sulfoxides |
CA1067892A (en) * | 1975-06-23 | 1979-12-11 | Connlab Holdings Limited | Iodo compounds |
JPS6019315B2 (ja) * | 1976-01-23 | 1985-05-15 | 塩野義製薬株式会社 | アゼチジノン化合物 |
US4081443A (en) * | 1976-01-29 | 1978-03-28 | Shionogi & Co., Ltd. | Penicillin oxides |
US4375397A (en) * | 1976-03-15 | 1983-03-01 | E. R. Squibb & Sons, Inc. | Process for preparing 3-methylene cephalosporins |
US4171304A (en) * | 1976-06-14 | 1979-10-16 | Connlab Holdings Limited | 2-Iodomethylpenams |
GB1576219A (en) * | 1976-12-31 | 1980-10-01 | Connlab Holdings Ltd | Thiazoleneazetidinone derivatives |
US4187221A (en) * | 1976-12-31 | 1980-02-05 | Connlab Holdings Limited | Process for preparing azetidinones |
LU77306A1 (zh) * | 1977-05-09 | 1979-01-18 | ||
US4195021A (en) * | 1977-10-26 | 1980-03-25 | Eli Lilly And Company | 1,3-Disubstituted 2-azetidinone antibitotics |
US4340539A (en) * | 1980-01-21 | 1982-07-20 | Bristol-Myers Company | Derivatives of 6-bromo penicillanic acid |
DE3265390D1 (en) * | 1981-05-19 | 1985-09-19 | Ciba Geigy Ag | Process for the preparation of 4-thio-azetidinone compounds |
US4496484A (en) * | 1983-04-22 | 1985-01-29 | Taiho Pharmaceutical Company, Limited | Penicillin derivatives |
IN173329B (zh) * | 1989-11-06 | 1994-04-02 | Ranbaxy Lab Ltd | |
US5066400A (en) * | 1990-10-09 | 1991-11-19 | Donaldson Company, Inc. | Self-spaced pleated filter |
US5604222A (en) * | 1993-12-27 | 1997-02-18 | Lupin Laboratories, Ltd. | Method for the preparation of 2-chloro sulfinyl azetidinones |
US5578721A (en) * | 1994-07-11 | 1996-11-26 | Lupin Laboratories Limited | Process for preparation of 3-exomethylene cepham sulfoxide esters |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3197466A (en) * | 1961-10-30 | 1965-07-27 | Smith Kline French Lab | Penicillin sulfoxides and process |
US3466275A (en) * | 1962-07-31 | 1969-09-09 | Lilly Co Eli | Modified penicillins and their preparation via penicillin sulfoxides |
US3544581A (en) * | 1965-07-22 | 1970-12-01 | Bristol Myers Co | Production of 6-amino-penicillanic acid sulfoxide |
US3652546A (en) * | 1965-07-22 | 1972-03-28 | Bristol Myers Co | Esters of 6-aminopenicillanic acid |
US3304327A (en) * | 1966-03-02 | 1967-02-14 | Olin Mathieson | 2, 4-disubstituted carbohydrazides |
US3647786A (en) * | 1968-10-03 | 1972-03-07 | Lilly Co Eli | Preparation of cephalosporin sulfoxides |
DK136480B (da) * | 1969-03-11 | 1977-10-17 | Glaxo Lab Ltd | Fremgangsmåde til fremstilling af 7beta-acylamido-3-metylceph-3-em-4-karboxylsyreestere ved omlejring af en 6beta-acylamidopenicillansyre-1-oxydester. |
GB1312233A (en) * | 1969-12-05 | 1973-04-04 | Glaxo Lab Ltd | Cephalosporin compounds |
GB1332306A (en) * | 1969-12-23 | 1973-10-03 | Glaxo Lab Ltd | Antibiotics |
US3880833A (en) | 1970-10-27 | 1975-04-29 | Ciba Geigy Corp | Certain bis-(3-amino-2-oxo-1-azetidinyl)-disulfides |
US3862181A (en) * | 1970-10-28 | 1975-01-21 | Squibb & Sons Inc | Process for preparing cephalosporins |
GB1368235A (en) | 1970-11-03 | 1974-09-25 | Glaxo Lab Ltd | Azetidinone disulphides and their preparation |
US4174318A (en) | 1970-11-03 | 1979-11-13 | Glaxo Laboratories Ltd. | Alkylative cleavage of azetidinone disulfides |
GB1368236A (en) | 1970-11-03 | 1974-09-25 | Glaxo Lab Ltd | Azetidinone derivatives and their preparation |
US3843637A (en) * | 1971-05-11 | 1974-10-22 | Bristol Myers Co | Process for rearranging 6-acylamidopenicillanic acid-1-oxides to 7-acyla mido-3-methyl-ceph-3-em-4-carboxylic acids |
DE2265798C2 (de) * | 1971-06-24 | 1985-09-26 | Fujisawa Pharmaceutical Co., Ltd., Osaka | Verfahren zur Herstellung von Oxoazetidin-Derivaten |
JPS551272B2 (zh) * | 1972-04-14 | 1980-01-12 | ||
US3989685A (en) * | 1972-06-29 | 1976-11-02 | Shinogi & Co., Ltd. | Process for making a 2'-halopenicillin |
SE417968B (sv) * | 1972-10-20 | 1981-04-27 | Fujisawa Pharmaceutical Co | Forfarande for framstellning av penamderivat |
US3984397A (en) * | 1972-11-22 | 1976-10-05 | Fujisawa Pharmaceutical Co., Ltd. | 2,3-Lower alkylenepenam-3-carboxylic acid derivatives and processes for the preparation thereof |
US3843639A (en) * | 1973-02-08 | 1974-10-22 | Bristol Myers Co | Production of cephalexin via methoxymethyl ester |
DE2320040A1 (de) * | 1973-04-19 | 1974-11-07 | Bayer Ag | Verfahren zur herstellung von 7acylamino-desacetoxy-cephalosporansaeureester |
GB1465651A (en) | 1974-04-19 | 1977-02-23 | Wyeth John & Brother Ltd | Carbocyclic-fused ring pyridine derivatives |
US4039530A (en) | 1975-06-23 | 1977-08-02 | Connlab Holdings Limited | Thioamides |
DE2751640C2 (de) | 1977-11-17 | 1987-04-02 | Delbag-Luftfilter Gmbh, 1000 Berlin | Austauschbares Filterelement zur Reinigung von mit toxischen oder radioaktiven Bestandteilen beladenen Luft- oder Gasströmen in kerntechnischen Anlagen und Verfahren zum Austausch und zur Beseitigung von volumenverringerbaren verseuchten Filterelementen in Abfallbehälter |
-
1972
- 1972-06-21 DE DE2265798A patent/DE2265798C2/de not_active Expired
- 1972-06-21 FR FR7222399A patent/FR2143211B1/fr not_active Expired
- 1972-06-23 CH CH141976A patent/CH593293A5/xx not_active IP Right Cessation
- 1972-06-23 NL NL7208671A patent/NL7208671A/xx not_active Application Discontinuation
- 1972-06-23 CH CH142076A patent/CH593294A5/xx not_active IP Right Cessation
- 1972-06-23 CH CH141776A patent/CH578571A5/xx not_active IP Right Cessation
- 1972-06-23 CH CH944272A patent/CH591499A5/xx not_active IP Right Cessation
- 1972-06-23 CH CH142176A patent/CH578576A5/xx not_active IP Right Cessation
- 1972-06-23 CH CH141876A patent/CH578522A5/xx not_active IP Right Cessation
- 1972-06-26 GB GB5038574A patent/GB1403004A/en not_active Expired
- 1972-06-26 GB GB5014274A patent/GB1403003A/en not_active Expired
- 1972-06-26 GB GB4964274A patent/GB1403002A/en not_active Expired
- 1972-06-26 GB GB2990472A patent/GB1403001A/en not_active Expired
-
1973
- 1973-12-21 US US05/427,232 patent/US4009159A/en not_active Expired - Lifetime
-
1974
- 1974-01-04 US US05/430,688 patent/US3993646A/en not_active Expired - Lifetime
- 1974-11-04 CA CA213,109A patent/CA1012972A/en not_active Expired
-
1976
- 1976-08-05 US US05/711,965 patent/US4036847A/en not_active Expired - Lifetime
- 1976-08-05 US US05/711,980 patent/US4071527A/en not_active Expired - Lifetime
-
1980
- 1980-12-01 US US06/211,911 patent/US4435321A/en not_active Expired - Lifetime
-
1981
- 1981-01-26 US US06/228,621 patent/US4931555A/en not_active Expired - Lifetime
- 1981-12-07 US US06/328,267 patent/US4410458A/en not_active Expired - Lifetime
-
1984
- 1984-11-14 NL NL8403479A patent/NL8403479A/nl not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
GB1403001A (en) | 1975-08-13 |
NL8403479A (nl) | 1985-03-01 |
DE2265798C2 (de) | 1985-09-26 |
FR2143211B1 (zh) | 1975-10-31 |
CH593293A5 (zh) | 1977-11-30 |
CH578576A5 (zh) | 1976-08-13 |
FR2143211A1 (zh) | 1973-02-02 |
GB1403002A (en) | 1975-08-13 |
GB1403003A (en) | 1975-08-13 |
CH593294A5 (zh) | 1977-11-30 |
US4410458A (en) | 1983-10-18 |
CH578522A5 (zh) | 1976-08-13 |
US4931555A (en) | 1990-06-05 |
US4009159A (en) | 1977-02-22 |
US4071527A (en) | 1978-01-31 |
US4036847A (en) | 1977-07-19 |
US3993646A (en) | 1976-11-23 |
GB1403004A (en) | 1975-08-13 |
NL7208671A (zh) | 1972-12-28 |
CH591499A5 (zh) | 1977-09-30 |
CH578571A5 (zh) | 1976-08-13 |
US4435321A (en) | 1984-03-06 |
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