CA1011333A - (4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation - Google Patents

(4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation

Info

Publication number
CA1011333A
CA1011333A CA194,513A CA194513A CA1011333A CA 1011333 A CA1011333 A CA 1011333A CA 194513 A CA194513 A CA 194513A CA 1011333 A CA1011333 A CA 1011333A
Authority
CA
Canada
Prior art keywords
benzodiazepines
triazolo
dihydro
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA194,513A
Other languages
English (en)
Other versions
CA194513S (en
Inventor
Etienne Szarvasi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7308510A external-priority patent/FR2220257A1/fr
Priority claimed from FR7335522A external-priority patent/FR2246273A2/fr
Priority claimed from FR7341583A external-priority patent/FR2252102A2/fr
Application filed by LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA Liyonnaise Industrielle Pharmaceutique
Application granted granted Critical
Publication of CA1011333A publication Critical patent/CA1011333A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
CA194,513A 1973-03-09 1974-03-08 (4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation Expired CA1011333A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7308510A FR2220257A1 (en) 1973-03-09 1973-03-09 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects
FR7335522A FR2246273A2 (en) 1973-10-04 1973-10-04 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects
FR7341583A FR2252102A2 (en) 1973-11-22 1973-11-22 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects

Publications (1)

Publication Number Publication Date
CA1011333A true CA1011333A (en) 1977-05-31

Family

ID=27250074

Family Applications (1)

Application Number Title Priority Date Filing Date
CA194,513A Expired CA1011333A (en) 1973-03-09 1974-03-08 (4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation

Country Status (13)

Country Link
US (1) US4110337A (xx)
JP (1) JPS49125395A (xx)
CA (1) CA1011333A (xx)
CH (1) CH589084A5 (xx)
DD (1) DD110497A5 (xx)
DE (1) DE2409308C3 (xx)
DK (1) DK139099B (xx)
ES (1) ES424067A1 (xx)
GB (1) GB1409693A (xx)
IE (1) IE38931B1 (xx)
IL (1) IL44338A (xx)
NL (1) NL7403247A (xx)
NO (1) NO139048C (xx)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076823A (en) * 1977-08-18 1978-02-28 E. R. Squibb & Sons, Inc. Triazolo-2,4-benzodiazepines
US5683998A (en) * 1991-04-23 1997-11-04 Toray Industries, Inc. Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
DE69230125T2 (de) * 1991-04-23 2000-02-03 Toray Industries Tricyclische triazolderivate, ihre herstellung und ihre verwendung
FR2769309B1 (fr) 1997-10-08 2001-06-15 Oreal Composition de teinture d'oxydation des fibres keratiniques comprenant un derive d'aminoacide en tant que base d'oxydation et nouveaux derives d'aminoacides
US20030119029A1 (en) * 1999-04-30 2003-06-26 Regents Of The University Of Michigan Compositions and methods relating to novel benzodiazepine compounds and targets thereof
JP5127096B2 (ja) 1999-04-30 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アポトーシスにより誘導される自己免疫疾患を処置するためのベンゾジアゼピンの使用
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US7276348B2 (en) * 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US20040176358A1 (en) * 1999-04-30 2004-09-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US20050113460A1 (en) 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20060052369A1 (en) * 2004-09-07 2006-03-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
AU2006203946B2 (en) * 2005-01-03 2009-07-23 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20070043033A1 (en) * 2005-06-01 2007-02-22 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US20070105844A1 (en) * 2005-10-26 2007-05-10 Regents Of The University Of Michigan Therapeutic compositions and methods
NZ568254A (en) 2005-11-01 2011-06-30 Univ Michigan 1,4-Benzodiazepine-2,5-diones for regulating cell death and treating autoimmune diseases
DE102005061840A1 (de) 2005-12-23 2007-06-28 Merck Patent Gmbh Triazolderivate
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
MX2008015488A (es) 2006-06-09 2009-02-12 Univ Michigan Composiciones y metodos relacionados con compuestos novedosos y objetivos de los mismos.
WO2008112553A1 (en) 2007-03-09 2008-09-18 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
CA2698248C (en) 2007-09-14 2017-08-29 The Regents Of The University Of Michigan Phenyl acyl guanidine derivatives as f1f0-atpase inhibitors and the use thereof
JP5539212B2 (ja) 2007-11-06 2014-07-02 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 皮膚症状の治療に有用なベンゾジアゼピノン化合物
AU2009291632B2 (en) 2008-09-11 2013-04-04 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
WO2011035124A1 (en) 2009-09-18 2011-03-24 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
EP2501387B1 (en) 2009-11-17 2016-07-27 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
US8815845B2 (en) 2009-11-17 2014-08-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2705039B1 (en) * 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9328117B2 (en) 2011-06-17 2016-05-03 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681343A (en) * 1971-05-11 1972-08-01 Upjohn Co 6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines

Also Published As

Publication number Publication date
NO740833L (no) 1974-09-10
DD110497A5 (xx) 1974-12-20
GB1409693A (en) 1975-10-15
IL44338A (en) 1977-01-31
NO139048C (no) 1979-01-03
JPS49125395A (xx) 1974-11-30
US4110337A (en) 1978-08-29
IL44338A0 (en) 1974-06-30
ES424067A1 (es) 1976-06-01
DE2409308C3 (de) 1978-05-18
DE2409308B2 (de) 1977-09-22
DK139099B (da) 1978-12-18
AU6627674A (en) 1975-09-11
NO139048B (no) 1978-09-18
NL7403247A (xx) 1974-09-11
DK139099C (xx) 1979-05-28
DE2409308A1 (de) 1974-09-19
IE38931B1 (en) 1978-07-05
CH589084A5 (xx) 1977-06-30
IE38931L (en) 1974-09-09

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