CA1006525A - 5-substituted 2-amino-4-arylthiazoles and their preparation - Google Patents

5-substituted 2-amino-4-arylthiazoles and their preparation

Info

Publication number
CA1006525A
CA1006525A CA164,590A CA164590A CA1006525A CA 1006525 A CA1006525 A CA 1006525A CA 164590 A CA164590 A CA 164590A CA 1006525 A CA1006525 A CA 1006525A
Authority
CA
Canada
Prior art keywords
arylthiazoles
amino
substituted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA164,590A
Other languages
English (en)
Inventor
Elso Manghisi
Aldo Salimbeni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Luso Farmaco dItalia SpA
Original Assignee
Istituto Luso Farmaco dItalia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Luso Farmaco dItalia SpA filed Critical Istituto Luso Farmaco dItalia SpA
Application granted granted Critical
Publication of CA1006525A publication Critical patent/CA1006525A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CA164,590A 1972-02-25 1973-02-26 5-substituted 2-amino-4-arylthiazoles and their preparation Expired CA1006525A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2108672 1972-02-25
IT2023173 1973-02-09

Publications (1)

Publication Number Publication Date
CA1006525A true CA1006525A (en) 1977-03-08

Family

ID=26327456

Family Applications (1)

Application Number Title Priority Date Filing Date
CA164,590A Expired CA1006525A (en) 1972-02-25 1973-02-26 5-substituted 2-amino-4-arylthiazoles and their preparation

Country Status (9)

Country Link
US (1) US3933838A (xx)
JP (1) JPS5112630B2 (xx)
BE (1) BE795907A (xx)
CA (1) CA1006525A (xx)
DE (2) DE2309251A1 (xx)
ES (1) ES412052A1 (xx)
FR (1) FR2181764B1 (xx)
GB (1) GB1425505A (xx)
NL (1) NL7302528A (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025528A (en) * 1973-10-24 1977-05-24 Shionogi & Co., Ltd. Thiazole derivatives of benzoic and phenylalkanoic acids
DE2828091A1 (de) * 1978-06-27 1980-01-10 Boehringer Sohn Ingelheim 4-substituierte thiazoloxamsaeuren sowie ihre salze und ester
US4225719A (en) * 1978-12-29 1980-09-30 Eastman Kodak Company Process for preparing 2-amino-5-formylthiazole and its hydrobromide salt
US4336388A (en) * 1980-06-23 1982-06-22 Hoffmann-La Roche Inc. Thiazolyl benzophenone compounds
FR2581063B1 (fr) * 1985-04-30 1987-07-17 Chauvin Blache Lab Amino-2 thiazoles n-substitues, leur procede de preparation et leur application en therapeutique
US5000775A (en) * 1985-12-31 1991-03-19 Monsanto Company 2-amino-4,5-disubstituted-oxazole/thiazole compounds as herbicide antidotes
US4761422A (en) * 1986-11-20 1988-08-02 Lusofarmaco Istituto Lusofarmaco D'italia Spa (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same
AU644281B2 (en) * 1991-04-24 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Novel thiazole derivatives
US6337338B1 (en) 1998-12-15 2002-01-08 Telik, Inc. Heteroaryl-aryl ureas as IGF-1 receptor antagonists
EA007717B1 (ru) * 2001-08-13 2006-12-29 Янссен Фармацевтика Н.В. 2-амино-4,5-тризамещенные производные тиазолила
AU2002331227B2 (en) * 2001-08-13 2008-01-24 Janssen Pharmaceutica N.V. 2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity
WO2003072554A1 (en) * 2002-02-28 2003-09-04 Takeda Chemical Industries, Ltd. Azole compounds
AP2358A (en) * 2005-05-09 2012-01-30 Achillion Pharmaceuticals Inc Thiazole compounds and methods of use.
JP5341516B2 (ja) 2005-09-13 2013-11-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２−アニリン−４−アリール置換チアゾール誘導体
EP1996565A2 (en) * 2006-03-08 2008-12-03 Achillion Pharmaceuticals, Inc. Substituted aminothiazole derivatives with anti-hcv activity
AU2008257158A1 (en) * 2007-05-22 2008-12-04 Achillion Pharmaceuticals, Inc. Heteroaryl substituted thiazoles and their use as antiviral agents
US8440701B2 (en) * 2007-10-18 2013-05-14 Janssen Pharmaceutica Nv Trisubstituted 1,2,4 triazoles
JO2784B1 (en) * 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
NZ587669A (en) * 2008-03-19 2011-07-29 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators
BRPI0912196A2 (pt) * 2008-05-09 2015-10-06 Janssen Pharmaceutica Nv pirazóis trissubstituídos como moduladores do receptor de acetilcolina.
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2423709A (en) * 1947-07-08 X-aryl thiazole
US3575991A (en) * 1969-03-11 1971-04-20 American Home Prod 1-(4-aryl - 5 - carboxymethyl-2-thiazolyl)-1,6-dihydro -6 - oxonicotinic acids and esters thereof

Also Published As

Publication number Publication date
US3933838A (en) 1976-01-20
DE2365526A1 (de) 1975-07-31
FR2181764A1 (xx) 1973-12-07
GB1425505A (en) 1976-02-18
JPS4897868A (xx) 1973-12-13
DE2309251A1 (de) 1973-09-06
FR2181764B1 (xx) 1976-07-02
ES412052A1 (es) 1976-05-01
AU5246773A (en) 1974-08-22
BE795907A (fr) 1973-06-18
NL7302528A (xx) 1973-08-28
JPS5112630B2 (xx) 1976-04-21

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