BRPI1015311A2 - método, dispositivo e kit para determinar a quantidade de polipetídeo de neurotoxina processada e processada ativa em uma solução contendo polipeptídeo de neurotoxina processada e parcialmente processada e/ou não processada - Google Patents
método, dispositivo e kit para determinar a quantidade de polipetídeo de neurotoxina processada e processada ativa em uma solução contendo polipeptídeo de neurotoxina processada e parcialmente processada e/ou não processadaInfo
- Publication number
- BRPI1015311A2 BRPI1015311A2 BRPI1015311A BRPI1015311A BRPI1015311A2 BR PI1015311 A2 BRPI1015311 A2 BR PI1015311A2 BR PI1015311 A BRPI1015311 A BR PI1015311A BR PI1015311 A BRPI1015311 A BR PI1015311A BR PI1015311 A2 BRPI1015311 A2 BR PI1015311A2
- Authority
- BR
- Brazil
- Prior art keywords
- processed
- neurotoxin polypeptide
- kit
- determining
- solution containing
- Prior art date
Links
- 101710138657 Neurotoxin Proteins 0.000 title 2
- 239000002581 neurotoxin Substances 0.000 title 2
- 231100000618 neurotoxin Toxicity 0.000 title 2
- 229920001184 polypeptide Polymers 0.000 title 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 2
- 108090000765 processed proteins & peptides Proteins 0.000 title 2
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21465009P | 2009-04-27 | 2009-04-27 | |
| EP09158788 | 2009-04-27 | ||
| EP09158788.1 | 2009-04-27 | ||
| US61/214,650 | 2009-04-27 | ||
| PCT/EP2010/055432 WO2010124998A1 (en) | 2009-04-27 | 2010-04-23 | Means and methods for the determination of the amount of neurotoxin polypeptide and of its catalytic and proteolytic activities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1015311A2 true BRPI1015311A2 (pt) | 2016-04-19 |
| BRPI1015311B1 BRPI1015311B1 (pt) | 2024-01-09 |
Family
ID=41066304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1015311-0A BRPI1015311B1 (pt) | 2009-04-27 | 2010-04-23 | Método para determinar a quantidade de polipeptídeo de neurotoxina processada em uma solução, dispositivo para determinação da quantidade de polipeptídeo de neurotoxina processada contida em uma solução e kit adaptado |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8663942B2 (pt) |
| EP (1) | EP2425251B1 (pt) |
| JP (1) | JP5689113B2 (pt) |
| KR (1) | KR101818777B1 (pt) |
| CN (1) | CN102414564B (pt) |
| AU (1) | AU2010243692B2 (pt) |
| BR (1) | BRPI1015311B1 (pt) |
| CA (1) | CA2757637C (pt) |
| ES (1) | ES2647243T3 (pt) |
| HK (1) | HK1169171A1 (pt) |
| IL (1) | IL215441A (pt) |
| MX (1) | MX2011011045A (pt) |
| PT (1) | PT2425251T (pt) |
| RU (1) | RU2545783C9 (pt) |
| WO (1) | WO2010124998A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2544060T3 (es) * | 2010-08-11 | 2015-08-27 | Merz Pharma Gmbh & Co. Kgaa | Fabricación selectiva de polipéptidos de neurotoxina recombinantes |
| JP6156954B2 (ja) | 2012-11-21 | 2017-07-05 | イプセン バイオイノベーション リミテッド | タンパク分解性にプロセシングされたポリペプチドの製造方法 |
| JP6608357B2 (ja) * | 2013-06-28 | 2019-11-20 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 細胞において神経毒ポリペプチドの生物活性を決定する手段及び方法 |
| US10634683B2 (en) | 2014-11-21 | 2020-04-28 | Merz Pharma Gmbh & Co. Kgaa | Methods for the determination of the biological activities of neurotoxin polypeptides |
| RU2694964C2 (ru) * | 2017-12-19 | 2019-07-19 | ФЕДЕРАЛЬНОЕ АГЕНТСТВО ПО ТЕХНИЧЕСКОМУ РЕГУЛИРОВАНИЮ И МЕТРОЛОГИИ (Росстандарт) | Способ измерений каталитической активности (каталитической концентрации) ферментов с использованием методов масс-спектрометрии и спектрофотометрии с предварительной идентификацией целевого аналита и определением чистоты веществ |
| JP7394767B2 (ja) | 2018-01-12 | 2023-12-08 | ジェンザイム・コーポレーション | ポリペプチドの定量化方法 |
| WO2020206375A1 (en) * | 2019-04-03 | 2020-10-08 | Technical University Of Denmark | Neurotrophic factor protein conjugates and related embodiments |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| DE69033457T2 (de) * | 1989-08-16 | 2000-09-14 | Chiron Corp | Prohormonspaltungsplatzblockierungsantikörper |
| GB9411138D0 (en) * | 1994-06-03 | 1994-07-27 | Microbiological Res Authority | Toxin assay |
| DE60032367T3 (de) * | 1999-08-25 | 2011-03-10 | Allergan, Inc., Irvine | Aktivierbare rekombinante neurotoxine |
| US6678651B2 (en) | 2000-09-15 | 2004-01-13 | Mindspeed Technologies, Inc. | Short-term enhancement in CELP speech coding |
| US20060063221A1 (en) * | 2004-09-21 | 2006-03-23 | Williams Dudley J | Lanthanide-based substrates and methods for determining clostridial toxin activity |
| US7332567B2 (en) * | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
| JP5178009B2 (ja) * | 2003-12-19 | 2013-04-10 | ウィスコンシン アルムニ リサーチ ファンデイション | ボツリヌス神経毒素検出のための方法および複合体 |
| FR2869908B1 (fr) * | 2004-05-05 | 2006-07-28 | Pharmaleads | Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite |
| KR20100020972A (ko) * | 2007-06-01 | 2010-02-23 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리늄 톡신의 신경독 성분에 기초한 온도-안정한 근육 이완제를 제공하는 방법 |
| WO2008157374A1 (en) * | 2007-06-13 | 2008-12-24 | The United States Of America, As Represented By The Secretrary Of Agriculture | High-affinity monoclonal antibodies for botulinum toxin type a |
| EP2178905B1 (en) * | 2007-07-26 | 2013-11-06 | Allergan, Inc. | Methods of activiting clostridial toxins |
| CN101386648B (zh) * | 2008-09-25 | 2012-05-30 | 中国人民解放军军事医学科学院微生物流行病研究所 | 抗b型肉毒神经毒素中和性单克隆抗体、其制备方法及用途 |
| MX340772B (es) * | 2009-02-19 | 2016-07-26 | Merz Pharma Gmbh & Co Kgaa | Medios y metodos para fabricar neurotoxina altamente pura. |
-
2010
- 2010-04-23 US US13/138,948 patent/US8663942B2/en active Active
- 2010-04-23 CN CN201080018544.0A patent/CN102414564B/zh active Active
- 2010-04-23 PT PT107140378T patent/PT2425251T/pt unknown
- 2010-04-23 JP JP2012506517A patent/JP5689113B2/ja active Active
- 2010-04-23 KR KR1020117028244A patent/KR101818777B1/ko active IP Right Grant
- 2010-04-23 EP EP10714037.8A patent/EP2425251B1/en active Active
- 2010-04-23 RU RU2011147994/15A patent/RU2545783C9/ru active
- 2010-04-23 AU AU2010243692A patent/AU2010243692B2/en active Active
- 2010-04-23 WO PCT/EP2010/055432 patent/WO2010124998A1/en active Application Filing
- 2010-04-23 BR BRPI1015311-0A patent/BRPI1015311B1/pt active IP Right Grant
- 2010-04-23 ES ES10714037.8T patent/ES2647243T3/es active Active
- 2010-04-23 CA CA2757637A patent/CA2757637C/en active Active
- 2010-04-23 MX MX2011011045A patent/MX2011011045A/es active IP Right Grant
-
2011
- 2011-09-27 IL IL215441A patent/IL215441A/en active IP Right Grant
-
2012
- 2012-10-10 HK HK12109957.8A patent/HK1169171A1/xx unknown
-
2014
- 2014-01-16 US US14/157,046 patent/US20140134643A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN102414564A (zh) | 2012-04-11 |
| RU2545783C9 (ru) | 2016-02-27 |
| CA2757637C (en) | 2017-10-24 |
| AU2010243692A1 (en) | 2011-10-27 |
| IL215441A0 (en) | 2011-12-29 |
| ES2647243T3 (es) | 2017-12-20 |
| AU2010243692B2 (en) | 2015-03-05 |
| HK1169171A1 (en) | 2013-01-18 |
| RU2011147994A (ru) | 2013-06-10 |
| IL215441A (en) | 2015-04-30 |
| US20120142024A1 (en) | 2012-06-07 |
| MX2011011045A (es) | 2011-11-04 |
| EP2425251B1 (en) | 2017-10-25 |
| US8663942B2 (en) | 2014-03-04 |
| PT2425251T (pt) | 2017-11-27 |
| KR20120005041A (ko) | 2012-01-13 |
| CN102414564B (zh) | 2015-01-21 |
| JP2012525563A (ja) | 2012-10-22 |
| CA2757637A1 (en) | 2010-11-04 |
| KR101818777B1 (ko) | 2018-01-15 |
| US20140134643A1 (en) | 2014-05-15 |
| BRPI1015311B1 (pt) | 2024-01-09 |
| EP2425251A1 (en) | 2012-03-07 |
| JP5689113B2 (ja) | 2015-03-25 |
| RU2545783C2 (ru) | 2015-04-10 |
| WO2010124998A1 (en) | 2010-11-04 |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/04/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |