BRPI0923377A2 - Derivados de 1-amino-alquilciclohexano para o tratamento de doenças mediadas por mastócitos - Google Patents
Derivados de 1-amino-alquilciclohexano para o tratamento de doenças mediadas por mastócitosInfo
- Publication number
- BRPI0923377A2 BRPI0923377A2 BRPI0923377-6A BRPI0923377A BRPI0923377A2 BR PI0923377 A2 BRPI0923377 A2 BR PI0923377A2 BR PI0923377 A BRPI0923377 A BR PI0923377A BR PI0923377 A2 BRPI0923377 A2 BR PI0923377A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- mast cell
- mediated diseases
- cell mediated
- aminoalkylcyclohexane derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20319408P | 2008-12-19 | 2008-12-19 | |
EP08022151 | 2008-12-19 | ||
PCT/EP2009/009151 WO2010069595A1 (en) | 2008-12-19 | 2009-12-18 | 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0923377A2 true BRPI0923377A2 (pt) | 2015-07-21 |
Family
ID=40547765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0923377-6A BRPI0923377A2 (pt) | 2008-12-19 | 2009-12-18 | Derivados de 1-amino-alquilciclohexano para o tratamento de doenças mediadas por mastócitos |
Country Status (13)
Country | Link |
---|---|
US (3) | US8399519B2 (pt) |
EP (1) | EP2373304B1 (pt) |
JP (1) | JP5385402B2 (pt) |
KR (1) | KR101335118B1 (pt) |
CN (1) | CN102159201A (pt) |
AU (1) | AU2009328497A1 (pt) |
BR (1) | BRPI0923377A2 (pt) |
CA (1) | CA2737335C (pt) |
IL (1) | IL213607A0 (pt) |
MX (1) | MX2011006353A (pt) |
RU (1) | RU2484813C2 (pt) |
WO (1) | WO2010069595A1 (pt) |
ZA (1) | ZA201101789B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI432188B (zh) * | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之1-胺基-烷基環己烷衍生物類 |
US20130123541A1 (en) * | 2009-06-29 | 2013-05-16 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing 3,3,5,5-tetramethylcyclohexanone |
RU2014103098A (ru) * | 2011-06-30 | 2015-08-10 | Торэй Индастриз, Инк. | Противозудный агент |
US9492535B2 (en) | 2013-03-14 | 2016-11-15 | Aimmune Therapeutics, Inc. | Peanut formulations and uses thereof |
US9198869B2 (en) | 2013-03-14 | 2015-12-01 | Aimmune Therapeutics, Inc. | Manufacture of peanut formulations for oral desensitization |
WO2019089978A1 (en) | 2017-11-02 | 2019-05-09 | Aimmune Therapeutics, Inc. | Methods of oral immunotherapy |
CN113966229A (zh) | 2019-05-10 | 2022-01-21 | 爱沐疗法公司 | 用于改善花生过敏患者的生活质量的方法 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6024983A (en) | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
US4849222A (en) | 1987-03-24 | 1989-07-18 | The Procter & Gamble Company | Mixtures for treating hypercholesterolemia |
JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
US5288502A (en) | 1991-10-16 | 1994-02-22 | The University Of Texas System | Preparation and uses of multi-phase microspheres |
DK0724432T3 (da) | 1993-10-22 | 2003-01-27 | Genentech Inc | Fremgangsmåder og præparater til mikroindkapsling af antigener til brug som vacciner |
ATE189211T1 (de) * | 1994-06-01 | 2000-02-15 | Axys Pharm Inc | Zusammensetzungen und verfahren zur behandlung von durch mast-zellen verursachten krankheiten |
CZ29799A3 (cs) | 1996-07-30 | 1999-06-16 | Arris Pharmaceutical Corporation | Disubstituovaná cyklická sloučenina, způsob její výroby, farmaceutický přípravek a způsob léčení onemocnění živočicha |
PT870757E (pt) | 1997-04-10 | 2002-09-30 | Pfizer | Derivados de adamantano substituidos por fluoro |
US6071966A (en) * | 1997-06-30 | 2000-06-06 | Merz + Co. Gmbh & Co. | 1-amino-alkylcyclohexane NMDA receptor antagonists |
CZ293248B6 (cs) * | 1997-06-30 | 2004-03-17 | Merz Pharma Gmbh & Co. Kgaa | 1-Aminocyklohexanový derivát a farmaceutická kompozice na jeho bázi |
FR2768624B1 (fr) | 1997-09-25 | 1999-11-12 | Oreal | Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue |
SE9801494D0 (sv) | 1998-04-28 | 1998-04-28 | Astra Pharma Prod | Novel use |
US6345421B1 (en) | 2000-05-12 | 2002-02-12 | Milliken & Company | Fabric treatment apparatus comprising easily removable, lightweight, treatment tubes |
TW593223B (en) | 2000-06-20 | 2004-06-21 | Merz Pharma Gmbh & Co Kgaa | 1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists |
FR2813189B1 (fr) | 2000-08-31 | 2003-02-28 | Oreal | Creme cosmetique moussante pour le traitement des peaux grasses |
US20040102525A1 (en) * | 2002-05-22 | 2004-05-27 | Kozachuk Walter E. | Compositions and methods of treating neurological disease and providing neuroprotection |
DE10252665A1 (de) * | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
UA80055C2 (en) | 2003-05-27 | 2007-08-10 | Forest Laboratories | Combination of nmda-receptor antagonist and selective inhibitor of serotonin reuptake for a depression and other pscihiatric disorders treatment |
AU2004258751C1 (en) * | 2003-07-28 | 2008-07-17 | Merz Pharma Gmbh & Co. Kgaa | The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity |
AR046314A1 (es) | 2003-11-05 | 2005-11-30 | Merz Pharma Gmbh & Co Kgaa | Composiciones que comprenden ciclohexilaminas y aminoadamantanos |
US20050137122A1 (en) | 2003-12-17 | 2005-06-23 | Alcon, Inc. | Use of agents that prevent generation of amyloid and amyloid-like lipoproteins, and/or use of agents that promote sequestration and/or degradation of, and/or prevent neurotoxicity of such proteins in the treatment of hearing loss and improving body balance |
US20050196418A1 (en) | 2004-03-04 | 2005-09-08 | Yu Ruey J. | Bioavailability and improved delivery of alkaline pharmaceutical drugs |
US20060002999A1 (en) | 2004-06-17 | 2006-01-05 | Forest Laboratories, Inc. | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
US20070141148A1 (en) * | 2005-11-30 | 2007-06-21 | Merz Pharma Gmbh & Co. Kgaa | Neramexane MR matrix tablet |
AU2007204755A1 (en) | 2006-01-10 | 2007-07-19 | Eugene J. Van Scott | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use |
EP1998788A4 (en) | 2006-03-01 | 2011-08-03 | Ruey J Yu | COMPOSITIONS AND METHODS FOR THE TOPIC TREATMENT OF DERMATOLOGICAL DISORDERS RESPONSIBLE FOR TAR |
WO2007117544A2 (en) * | 2006-04-07 | 2007-10-18 | Ssv Therapeutics, Inc. | Carnitine conjugates of adamantanamines and neramexane derivatives as duel prodrugs for various uses |
TW200819458A (en) * | 2006-06-23 | 2008-05-01 | Merz Pharma Gmbh & Co Kgaa | Metabotropic glutamate receptor modulators |
DE102007003582A1 (de) | 2007-01-24 | 2008-07-31 | Dr. August Wolff Gmbh & Co. Kg Arzneimittel | Verwendung einer kosmetischen Zusammensetzung zur kosmetischen Behandlung der Haut |
TWI432188B (zh) | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之1-胺基-烷基環己烷衍生物類 |
-
2009
- 2009-12-18 AU AU2009328497A patent/AU2009328497A1/en not_active Abandoned
- 2009-12-18 BR BRPI0923377-6A patent/BRPI0923377A2/pt not_active IP Right Cessation
- 2009-12-18 JP JP2011538907A patent/JP5385402B2/ja not_active Expired - Fee Related
- 2009-12-18 MX MX2011006353A patent/MX2011006353A/es not_active Application Discontinuation
- 2009-12-18 KR KR1020117011426A patent/KR101335118B1/ko not_active IP Right Cessation
- 2009-12-18 WO PCT/EP2009/009151 patent/WO2010069595A1/en active Application Filing
- 2009-12-18 CN CN2009801358707A patent/CN102159201A/zh active Pending
- 2009-12-18 EP EP09796319.3A patent/EP2373304B1/en active Active
- 2009-12-18 US US12/998,962 patent/US8399519B2/en not_active Expired - Fee Related
- 2009-12-18 CA CA2737335A patent/CA2737335C/en not_active Expired - Fee Related
- 2009-12-18 RU RU2011129830/15A patent/RU2484813C2/ru not_active IP Right Cessation
-
2011
- 2011-03-08 ZA ZA2011/01789A patent/ZA201101789B/en unknown
- 2011-06-16 IL IL213607A patent/IL213607A0/en unknown
-
2013
- 2013-02-13 US US13/766,145 patent/US8680149B2/en not_active Expired - Fee Related
- 2013-12-18 US US14/132,575 patent/US20140107212A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2737335C (en) | 2013-10-01 |
RU2484813C2 (ru) | 2013-06-20 |
KR101335118B1 (ko) | 2013-12-05 |
IL213607A0 (en) | 2011-07-31 |
US8680149B2 (en) | 2014-03-25 |
US20130158124A1 (en) | 2013-06-20 |
RU2011129830A (ru) | 2013-01-27 |
WO2010069595A1 (en) | 2010-06-24 |
AU2009328497A1 (en) | 2010-06-24 |
MX2011006353A (es) | 2011-07-13 |
CN102159201A (zh) | 2011-08-17 |
JP5385402B2 (ja) | 2014-01-08 |
ZA201101789B (en) | 2012-01-25 |
US20110251283A1 (en) | 2011-10-13 |
KR20110074604A (ko) | 2011-06-30 |
CA2737335A1 (en) | 2010-06-24 |
JP2012510967A (ja) | 2012-05-17 |
EP2373304B1 (en) | 2014-07-30 |
EP2373304A1 (en) | 2011-10-12 |
US8399519B2 (en) | 2013-03-19 |
US20140107212A1 (en) | 2014-04-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |