BRPI0923300A2 - "derivados de nitrato de cilostazol para o tratamento de doenças vasculares e metabólicas" - Google Patents
"derivados de nitrato de cilostazol para o tratamento de doenças vasculares e metabólicas"Info
- Publication number
- BRPI0923300A2 BRPI0923300A2 BRPI0923300A BRPI0923300A BRPI0923300A2 BR PI0923300 A2 BRPI0923300 A2 BR PI0923300A2 BR PI0923300 A BRPI0923300 A BR PI0923300A BR PI0923300 A BRPI0923300 A BR PI0923300A BR PI0923300 A2 BRPI0923300 A2 BR PI0923300A2
- Authority
- BR
- Brazil
- Prior art keywords
- cilostazol
- vascular
- treatment
- metabolic diseases
- nitrate derivatives
- Prior art date
Links
- 229960004588 cilostazol Drugs 0.000 title abstract 4
- -1 cilostazol nitrate derivatives Chemical class 0.000 title abstract 3
- 208000030159 metabolic disease Diseases 0.000 title abstract 3
- 230000002792 vascular Effects 0.000 title abstract 3
- 208000019553 vascular disease Diseases 0.000 title abstract 3
- RRGUKTPIGVIEKM-UHFFFAOYSA-N cilostazol Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08170435A EP2194048A1 (en) | 2008-12-02 | 2008-12-02 | Nitrate esters for the treatment of vascular and metabolic diseases |
| PCT/EP2009/066159 WO2010063724A1 (en) | 2008-12-02 | 2009-12-01 | Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0923300A2 true BRPI0923300A2 (pt) | 2019-07-16 |
Family
ID=40456966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0923300A BRPI0923300A2 (pt) | 2008-12-02 | 2009-12-01 | "derivados de nitrato de cilostazol para o tratamento de doenças vasculares e metabólicas" |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8426597B2 (https=) |
| EP (2) | EP2194048A1 (https=) |
| JP (1) | JP2012510502A (https=) |
| KR (1) | KR20110088598A (https=) |
| CN (1) | CN102245583A (https=) |
| AU (1) | AU2009324123A1 (https=) |
| BR (1) | BRPI0923300A2 (https=) |
| CA (1) | CA2745252A1 (https=) |
| IL (1) | IL213214A0 (https=) |
| MX (1) | MX2011005744A (https=) |
| RU (1) | RU2011126607A (https=) |
| SG (1) | SG171423A1 (https=) |
| WO (1) | WO2010063724A1 (https=) |
| ZA (1) | ZA201104011B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011131613A1 (en) | 2010-04-19 | 2011-10-27 | Cardiolynx Ag | Valsartan derivatives carrying nitrogen oxide donors for the treatment of vascular and metabolic diseases |
| AR081268A1 (es) | 2010-06-02 | 2012-07-18 | Cardiolynx Ag | Derivados de nitrato de pioglitazona |
| ES2691092T3 (es) | 2012-08-21 | 2018-11-23 | Janssen Pharmaceutica Nv | Anticuerpos contra la risperidona y uso de los mismos |
| CN104837838A (zh) | 2012-08-21 | 2015-08-12 | 詹森药业有限公司 | 帕潘立酮半抗原 |
| PL2888592T3 (pl) | 2012-08-21 | 2018-03-30 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| CA2882596C (en) | 2012-08-21 | 2019-05-14 | Ortho-Clinical Diagnostics, Inc. | Antibodies to olanzapine and use thereof |
| WO2014031656A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine haptens and use thereof |
| JP6131414B2 (ja) | 2012-08-21 | 2017-05-24 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールのハプテン及びイムノアッセイにおけるそれらの使用 |
| CA2882562C (en) | 2012-08-21 | 2019-08-27 | Eric Hryhorenko | Antibodies to aripiprazole and use thereof |
| JP2015527365A (ja) | 2012-08-21 | 2015-09-17 | オルソ−クリニカル ダイアグノスティクス，インコーポレイティド | パリペリドンに対する抗体及びその使用 |
| ES2669565T3 (es) | 2012-08-21 | 2018-05-28 | Janssen Pharmaceutica Nv | Haptenos de risperidona y paliperidona |
| PL2888257T3 (pl) | 2012-08-21 | 2018-02-28 | Janssen Pharmaceutica Nv | Hapteny kwetiapiny do zastosowania w testach immunologicznych |
| JP2015529199A (ja) | 2012-08-21 | 2015-10-05 | オルソ−クリニカル ダイアグノスティクス，インコーポレイティド | パリペリドンハプテンに対する抗体及びその使用 |
| CN104854110B (zh) | 2012-08-21 | 2016-12-28 | 詹森药业有限公司 | 奥氮平半抗原 |
| EP2888284B1 (en) | 2012-08-21 | 2022-07-06 | Janssen Pharmaceutica NV | Antibodies to risperidone haptens and use thereof |
| JP6389176B2 (ja) | 2012-08-21 | 2018-09-12 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールハプテンに対する抗体及びその使用 |
| JP6450314B2 (ja) | 2012-08-21 | 2019-01-09 | ヤンセン ファーマシューティカ エヌ．ベー． | クエチアピンハプテンに対する抗体及びその使用 |
| EP3390449A1 (en) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica N.V. | Antibodies to risperidone and use thereof |
| US10435478B2 (en) | 2015-12-17 | 2019-10-08 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| CN114044766B (zh) * | 2021-10-09 | 2022-12-27 | 张北北九食品检验技术有限公司 | 放射性同位素碳-14标记的呋虫胺和中间体及其制备方法和应用 |
| CN120441542B (zh) * | 2025-05-08 | 2025-09-30 | 安徽益普克医药科技发展有限公司 | 一种西洛他唑衍生物及其制备方法与用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535019A (en) | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| US6148496A (en) | 1999-04-09 | 2000-11-21 | The Procter & Gamble Company | Method for making a seamless apertured metal belt |
| IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| PL379420A1 (pl) | 2003-07-31 | 2006-09-04 | Nicox S.A. | Pochodne blokerów receptora angiotensyny II |
| WO2006079610A1 (en) * | 2005-01-31 | 2006-08-03 | Nicox S.A. | Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases |
| EP1922069A2 (en) * | 2005-08-08 | 2008-05-21 | Nitromed, Inc. | Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use |
-
2008
- 2008-12-02 EP EP08170435A patent/EP2194048A1/en not_active Withdrawn
-
2009
- 2009-12-01 BR BRPI0923300A patent/BRPI0923300A2/pt not_active Application Discontinuation
- 2009-12-01 EP EP09793498A patent/EP2367803A1/en not_active Withdrawn
- 2009-12-01 MX MX2011005744A patent/MX2011005744A/es not_active Application Discontinuation
- 2009-12-01 KR KR1020117015258A patent/KR20110088598A/ko not_active Withdrawn
- 2009-12-01 RU RU2011126607/04A patent/RU2011126607A/ru unknown
- 2009-12-01 US US13/131,722 patent/US8426597B2/en not_active Expired - Fee Related
- 2009-12-01 WO PCT/EP2009/066159 patent/WO2010063724A1/en not_active Ceased
- 2009-12-01 CA CA2745252A patent/CA2745252A1/en not_active Abandoned
- 2009-12-01 JP JP2011538999A patent/JP2012510502A/ja not_active Ceased
- 2009-12-01 SG SG2011038213A patent/SG171423A1/en unknown
- 2009-12-01 CN CN200980149072XA patent/CN102245583A/zh active Pending
- 2009-12-01 AU AU2009324123A patent/AU2009324123A1/en not_active Abandoned
-
2011
- 2011-05-30 IL IL213214A patent/IL213214A0/en unknown
- 2011-05-31 ZA ZA2011/04011A patent/ZA201104011B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010063724A1 (en) | 2010-06-10 |
| RU2011126607A (ru) | 2013-01-10 |
| EP2194048A1 (en) | 2010-06-09 |
| CN102245583A (zh) | 2011-11-16 |
| IL213214A0 (en) | 2011-07-31 |
| ZA201104011B (en) | 2012-02-29 |
| KR20110088598A (ko) | 2011-08-03 |
| MX2011005744A (es) | 2011-06-20 |
| JP2012510502A (ja) | 2012-05-10 |
| AU2009324123A1 (en) | 2011-07-21 |
| EP2367803A1 (en) | 2011-09-28 |
| CA2745252A1 (en) | 2010-06-10 |
| US20110230520A1 (en) | 2011-09-22 |
| SG171423A1 (en) | 2011-07-28 |
| US8426597B2 (en) | 2013-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B15I | Others concerning applications: loss of priority |
Free format text: PERDA DA PRIORIDADE REIVINDICADA EP 08170435.5 DE 02.12.2008 POIS NAO FOI RESPONDIDA A EXIGENCIA FORMULADA NA RPI 2518 DE 09/04/2019 SOBRE ESTA PRIORIDADE. |
|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |