BRPI0813744B8 - Método para rechear uma primeira coluna com uma suspensão espessa de um meio cromatográfico para obter uma altura de leito desejada de meio recheado dentro da coluna - Google Patents

Método para rechear uma primeira coluna com uma suspensão espessa de um meio cromatográfico para obter uma altura de leito desejada de meio recheado dentro da coluna

Info

Publication number
BRPI0813744B8
BRPI0813744B8 BRPI0813744A BRPI0813744A BRPI0813744B8 BR PI0813744 B8 BRPI0813744 B8 BR PI0813744B8 BR PI0813744 A BRPI0813744 A BR PI0813744A BR PI0813744 A BRPI0813744 A BR PI0813744A BR PI0813744 B8 BRPI0813744 B8 BR PI0813744B8
Authority
BR
Brazil
Prior art keywords
column
chromatographic medium
bed height
medium
concentration
Prior art date
Application number
BRPI0813744A
Other languages
English (en)
Inventor
Marcus Joakim Lundkvist Sven
Lovman Esfir
Ehring Hanno
Original Assignee
Ge Healthcare Bio Sciences Ab
Cytiva Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Bio Sciences Ab, Cytiva Sweden Ab filed Critical Ge Healthcare Bio Sciences Ab
Publication of BRPI0813744A2 publication Critical patent/BRPI0813744A2/pt
Publication of BRPI0813744B1 publication Critical patent/BRPI0813744B1/pt
Publication of BRPI0813744B8 publication Critical patent/BRPI0813744B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/206—Packing or coating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
    • G01F23/28—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
    • G01F23/284—Electromagnetic waves
    • G01F23/292—Light, e.g. infrared or ultraviolet
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
    • G01F23/28—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
    • G01F23/296—Acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • G01N2030/562—Packing methods or coating methods packing
    • G01N2030/565—Packing methods or coating methods packing slurry packing

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Electromagnetism (AREA)
  • Fluid Mechanics (AREA)
  • Analytical Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

MÉTODOS PARA DETERMINAR A CONCENTRRAÇÃO DE UM MEIO CROMATOGRÁFICO EM UMA SUSPENSÃO ESPESSA LÍQUIDA, E PARA RECHEAR UMA PRIMEIRA COLUNA COM UMA SUSPENSÃO ESPESSA DE UM MEIO CROMATOGRÁFICO PARA OBTER UMA ALTURA DE LEITO DESEJADA DE MEIO RECHEADO DENTRO DA COLUNA, E, DISPOSITIVO PARA DETERMINAR A CONCENTRAÇÃO DE UM MEIO CROMATOGRÁFICO EM UMA SUSPENSÃO ESPESSA LÍQUIDA Um método para determinar a concentração de um meio cromatográfico em uma suspensão espessa líquida compreende as etapas de prover uma coluna (1) tendo uma extremidade de topo (3) e uma extremidade de base (2) e adaptada para reter um meio cromatográfico nela, introduzir um volume definido da suspensão espessa (15) dentro da coluna (1), prover um fluxo de líquido através da coluna (1) a partir da extremidade de topo até a extremidade de base da coluna, para precipitar o meio cromatográfico na coluna, medir a altura do leito do meio cromatográfico consolidado ou um valor relacionado com ele e determinar pela altura de leito medida ou valor relacionado com ela a concentração ou um valor relacionado com a concentração do meio cromatográfico na suspensão espessa. Um dispositivo para realizar o método, bem como o uso do método no recheio de colunas especialmente de grande proporção são também descritos.
BRPI0813744A 2007-07-06 2008-07-04 Método para rechear uma primeira coluna com uma suspensão espessa de um meio cromatográfico para obter uma altura de leito desejada de meio recheado dentro da coluna BRPI0813744B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0701671 2007-07-06
SE0701671-0 2007-07-06
PCT/EP2008/058691 WO2009007321A1 (en) 2007-07-06 2008-07-04 Determination of slurry concentration

Publications (3)

Publication Number Publication Date
BRPI0813744A2 BRPI0813744A2 (pt) 2015-09-08
BRPI0813744B1 BRPI0813744B1 (pt) 2021-01-05
BRPI0813744B8 true BRPI0813744B8 (pt) 2022-07-05

Family

ID=40003125

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813744A BRPI0813744B8 (pt) 2007-07-06 2008-07-04 Método para rechear uma primeira coluna com uma suspensão espessa de um meio cromatográfico para obter uma altura de leito desejada de meio recheado dentro da coluna

Country Status (8)

Country Link
US (1) US8117901B2 (pt)
EP (1) EP2167952B1 (pt)
JP (1) JP5734649B2 (pt)
KR (1) KR101513750B1 (pt)
CN (1) CN101688853B (pt)
BR (1) BRPI0813744B8 (pt)
CA (1) CA2691189C (pt)
WO (1) WO2009007321A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2458724C2 (ru) * 2007-03-06 2012-08-20 Джи-И Хелткер Био-Сайенсиз Корп. Система и способ автоматизации набивки колонки средой
JP2010230575A (ja) * 2009-03-27 2010-10-14 Nippon Rensui Co Ltd クロマトグラフィー用カラムの充填方法
US8634828B2 (en) * 2009-06-08 2014-01-21 Qualcomm Incorporated Method and apparatus for switching virtual SIM service contracts based upon a user profile
KR102081249B1 (ko) * 2013-05-27 2020-02-26 삼성디스플레이 주식회사 모니터링 장치 및 프린팅 장치
EP4268918A3 (en) * 2013-09-30 2024-01-24 Cytiva Sweden AB Method for transferring slurry
US20160245782A1 (en) * 2013-10-08 2016-08-25 Kaneka Corportion Method for preparing a small-diameter chromatography column
US10330654B2 (en) * 2014-07-20 2019-06-25 Sabic Global Technologies B.V. Methods for determining low sulfate concentrations in synthetic urea samples, produced in a manufacturing process and containing high levels of impurities
WO2018060496A1 (en) * 2016-09-30 2018-04-05 Ge Healthcare Bio-Sciences Ab Method and system for transferring separation resin
GB201701576D0 (en) 2017-01-31 2017-03-15 Ge Healthcare Bio Sciences Ab Method and system for transferring separation resin
IL310934A (en) * 2017-10-17 2024-04-01 Regeneron Pharma Methods for determining mixture for resin chromatography
TW202300208A (zh) * 2021-03-17 2023-01-01 日商日本水產股份有限公司 純化的方法及純化的製品

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3281019A (en) * 1963-10-22 1966-10-25 John P Curry Material dispenser for packing a column of narrow tubing
GB2394191B (en) 2000-07-28 2005-01-12 Euroflow Chromatography methods and chromatography apparatus
IL148898A0 (en) * 2000-07-28 2002-09-12 Euroflow Uk Ltd Methods and apparatus for packing chromatography columns and chromatography column
US6402958B1 (en) * 2000-08-17 2002-06-11 Uop Llc Chromatography column loading method
US7419599B2 (en) * 2005-07-12 2008-09-02 Ge Healthcare Bio-Sciences Ab Automated packing system and method for chromatography columns
US7452471B2 (en) * 2005-10-21 2008-11-18 Ge Healthcare Bio-Sciences Ab Automated packing system and method for chromatography columns
KR101280731B1 (ko) 2005-05-20 2013-07-01 지이 헬스케어 바이오-사이언시스 에이비 크로마토그래피 컬럼의 자동화 충전에 사용되는 장치 및방법
RU2458724C2 (ru) * 2007-03-06 2012-08-20 Джи-И Хелткер Био-Сайенсиз Корп. Система и способ автоматизации набивки колонки средой

Also Published As

Publication number Publication date
EP2167952A1 (en) 2010-03-31
CA2691189A1 (en) 2009-01-15
CA2691189C (en) 2017-01-10
US20090007643A1 (en) 2009-01-08
BRPI0813744A2 (pt) 2015-09-08
BRPI0813744B1 (pt) 2021-01-05
KR101513750B1 (ko) 2015-04-20
KR20100065140A (ko) 2010-06-15
WO2009007321A1 (en) 2009-01-15
CN101688853A (zh) 2010-03-31
CN101688853B (zh) 2014-07-23
JP5734649B2 (ja) 2015-06-17
JP2010532470A (ja) 2010-10-07
US8117901B2 (en) 2012-02-21
EP2167952B1 (en) 2021-03-17

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/04/2019, OBSERVADAS AS CONDICOES LEGAIS

B16D Grant of patent or certificate of addition of invention cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 16.1 NA RPI NO 2520 DE 25/04/2019 POR TER SIDO INDEVIDA.

B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/01/2021, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: CYTIVA SWEDEN AB (SE)