BRPI0811947A2 - COMPOUND, PROCESS FOR PREPARATION OF A COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND AND OBESITY TREATMENT METHOD, TYPE II DIABETES, DYSLIPIDEMIA OR METABOLIC SYNDROME - Google Patents
COMPOUND, PROCESS FOR PREPARATION OF A COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND AND OBESITY TREATMENT METHOD, TYPE II DIABETES, DYSLIPIDEMIA OR METABOLIC SYNDROMEInfo
- Publication number
- BRPI0811947A2 BRPI0811947A2 BRPI0811947-3A2A BRPI0811947A BRPI0811947A2 BR PI0811947 A2 BRPI0811947 A2 BR PI0811947A2 BR PI0811947 A BRPI0811947 A BR PI0811947A BR PI0811947 A2 BRPI0811947 A2 BR PI0811947A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- dyslipidemia
- diabetes
- preparation
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93132707P | 2007-05-22 | 2007-05-22 | |
| US93127307P | 2007-05-22 | 2007-05-22 | |
| US93136907P | 2007-05-22 | 2007-05-22 | |
| US93130307P | 2007-05-22 | 2007-05-22 | |
| PCT/EP2008/055843 WO2008141976A1 (en) | 2007-05-22 | 2008-05-13 | Diacylglycerol acyltransferase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0811947A2 true BRPI0811947A2 (en) | 2014-11-11 |
Family
ID=39619031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0811947-3A2A BRPI0811947A2 (en) | 2007-05-22 | 2008-05-13 | COMPOUND, PROCESS FOR PREPARATION OF A COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND AND OBESITY TREATMENT METHOD, TYPE II DIABETES, DYSLIPIDEMIA OR METABOLIC SYNDROME |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2155687A1 (en) |
| CN (1) | CN101835757B (en) |
| AU (1) | AU2008253118B2 (en) |
| BR (1) | BRPI0811947A2 (en) |
| CA (1) | CA2686951C (en) |
| HK (1) | HK1148519A1 (en) |
| MX (1) | MX2009012285A (en) |
| WO (1) | WO2008141976A1 (en) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2588162A1 (en) | 2004-12-14 | 2006-06-22 | Astrazeneca Ab | Oxadiazole derivatives as dgat inhibitors |
| EP1966221A1 (en) | 2005-12-22 | 2008-09-10 | AstraZeneca AB | Pyrimido- [4, 5-]-oxazines for use as dgat inhibitors |
| EP2402318A1 (en) | 2006-03-31 | 2012-01-04 | Novartis AG | DGAT inhibitors |
| BRPI0712802A2 (en) | 2006-05-30 | 2012-10-23 | Astrazeneca Ab | compound, methods for producing an inhibition of dgat1 activity, and for treating diabetes mellitus and / or obesity in a warm-blooded animal, use of a compound, pharmaceutical composition, and process for preparing a compound |
| US8153644B2 (en) | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8115011B2 (en) | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8058299B2 (en) | 2007-05-22 | 2011-11-15 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| ES2483898T3 (en) | 2007-06-08 | 2014-08-08 | Janssen Pharmaceutica, N.V. | Piperidine / Piperazine Derivatives |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine/Piperazine derivatives |
| ES2558152T3 (en) | 2007-06-08 | 2016-02-02 | Janssen Pharmaceutica, N.V. | Piperidine / Piperazine Derivatives |
| BRPI0813331A2 (en) | 2007-06-08 | 2014-12-23 | Janssen Pharmaceutica Nv | PIPERIDINE / PIPERAZINE Derivatives |
| AR066169A1 (en) | 2007-09-28 | 2009-07-29 | Novartis Ag | DERIVATIVES OF BENZO-IMIDAZOLES, USEFUL FOR DISORDERS ASSOCIATED WITH THE ACTIVITY OF DGAT |
| PE20140572A1 (en) * | 2008-06-05 | 2014-05-16 | Janssen Pharmaceutica Nv | DRUG COMBINATIONS INCLUDING A DGAT INHIBITOR AND A PPAR AGONIST |
| US8211884B2 (en) | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8324385B2 (en) | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| JP2012509274A (en) | 2008-11-19 | 2012-04-19 | シェーリング コーポレイション | Diacylglycerol acyltransferase inhibitors |
| US8124766B2 (en) | 2008-12-03 | 2012-02-28 | Madrigal Pharmaceuticals, Inc. | Inhibitors of diacylglycerol acyltransferase |
| EP2378878A4 (en) * | 2008-12-17 | 2012-08-01 | Via Pharmaceuticals Inc | Inhibitors of diacylglycerol acyltransferase |
| EP2404902A1 (en) * | 2009-03-05 | 2012-01-11 | Shionogi&Co., Ltd. | Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism |
| WO2011078102A1 (en) * | 2009-12-22 | 2011-06-30 | 第一三共株式会社 | Novel phenoxypyrimidine derivative |
| US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| US9150555B2 (en) | 2010-10-14 | 2015-10-06 | Mitsubishi Tanabe Pharma Corporation | Amide derivative and use thereof |
| TW201236685A (en) * | 2010-11-11 | 2012-09-16 | Daiichi Sankyo Co Ltd | New pyrazole amide derivatives |
| CN102924446B (en) | 2011-08-11 | 2015-08-26 | 上海吉铠医药科技有限公司 | PIM kinase inhibitor and preparation method thereof and the application in pharmacy |
| US9453003B2 (en) * | 2011-08-11 | 2016-09-27 | Jikai Biosciences, Inc. | Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
| US9452995B2 (en) * | 2011-08-11 | 2016-09-27 | Jikai Biosciences, Inc. | Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
| US9458151B2 (en) * | 2011-08-11 | 2016-10-04 | Jikai Biosciences, Inc. | Isothiazole derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
| RU2014141046A (en) | 2012-04-13 | 2016-04-27 | Мицубиси Танабе Фарма Корпорейшн | AMIDOPYRIDINE DERIVATIVE AND ITS USE |
| CN104672164A (en) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | SGLT2/SGLT1 double-target inhibitor containing benzene amidine structure as well as preparation method and application of inhibitor |
| CN104592151A (en) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | Tert-butyl amidine structure containing SGLT2/SGLT1 dual-target inhibitor and application thereof |
| CN104592149A (en) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | Tert-butyl amidine structure containing alkoxyphenyl thiazolecarboxylic acid amide dual-target inhibitor, as well as preparation method and application thereof |
| CN104557765A (en) * | 2015-02-10 | 2015-04-29 | 佛山市赛维斯医药科技有限公司 | Halophenyl thiazolecarboxylic acid amide double-target inhibitor containing amidine structure, as well as preparation method and application thereof |
| CN104710382A (en) * | 2015-02-10 | 2015-06-17 | 佛山市赛维斯医药科技有限公司 | Halogeneated phenyl thiazole carboxylic acid amides compounds containing tertiary butyl amidine structures and application |
| CN104610187B (en) * | 2015-02-10 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | One class is containing alkoxyphenyl radical thiazole carboxylic acid amides class two target spot inhibitor, the Preparation Method And The Use of amidine structure |
| CN104672165B (en) * | 2015-02-10 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | One class is containing alkoxyphenyl radical thiazole carboxylic acid amides's class two target spot inhibitor, the Preparation Method And The Use of cyclopropyl amidine structure |
| CN104610189A (en) * | 2015-02-10 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | SGLT2/SGLT1 double-target-point inhibitor containing cyclopropyl amidine structure and application of SGLT2/SGLT1 double-target-point inhibitor |
| CN104672166A (en) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | Cyanophenyl thiazolecarboxylic acid amide double-target inhibitor containing amidine structure as well as preparation method and application of inhibitor |
| JP6814814B2 (en) | 2016-03-17 | 2021-01-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 5-Ethyl-4-methyl-pyrazole-3-carboxamide derivative with activity as an agonist of TAAR |
| EA202090871A1 (en) | 2017-10-06 | 2020-07-03 | Форма Терапьютикс, Инк. | INHIBITION OF UBIKVITIN-SPECIFIC PEPTIDASE 30 |
| CN112513036B (en) | 2018-05-17 | 2024-05-24 | 福马治疗有限公司 | Fused bicyclic compounds useful as ubiquitin-specific peptidase 30 inhibitors |
| AU2019356011A1 (en) | 2018-10-05 | 2021-04-01 | Forma Therapeutics, Inc. | Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4436129B2 (en) * | 2001-08-31 | 2010-03-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Diarylcycloalkyl derivatives, process for their preparation and their use as PPAR-activators |
| WO2004022551A1 (en) * | 2002-09-06 | 2004-03-18 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| KR20080015113A (en) * | 2005-06-11 | 2008-02-18 | 아스트라제네카 아베 | Oxadiazole derivatives as dgat inhibitors |
| CA2630269C (en) * | 2005-11-28 | 2011-07-05 | F. Hoffmann-La Roche Ag | Inhibitors of diacyglycerol acyltransferase (dgat) |
-
2008
- 2008-05-13 AU AU2008253118A patent/AU2008253118B2/en not_active Ceased
- 2008-05-13 MX MX2009012285A patent/MX2009012285A/en active IP Right Grant
- 2008-05-13 WO PCT/EP2008/055843 patent/WO2008141976A1/en active Application Filing
- 2008-05-13 CN CN200880025656.1A patent/CN101835757B/en not_active Expired - Fee Related
- 2008-05-13 CA CA2686951A patent/CA2686951C/en not_active Expired - Fee Related
- 2008-05-13 BR BRPI0811947-3A2A patent/BRPI0811947A2/en not_active IP Right Cessation
- 2008-05-13 EP EP08759547A patent/EP2155687A1/en not_active Withdrawn
-
2011
- 2011-03-15 HK HK11102583.6A patent/HK1148519A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008253118B2 (en) | 2013-11-21 |
| WO2008141976A1 (en) | 2008-11-27 |
| MX2009012285A (en) | 2009-12-15 |
| EP2155687A1 (en) | 2010-02-24 |
| AU2008253118A1 (en) | 2008-11-27 |
| CN101835757A (en) | 2010-09-15 |
| HK1148519A1 (en) | 2011-09-09 |
| CN101835757B (en) | 2014-03-05 |
| CA2686951A1 (en) | 2008-11-27 |
| CA2686951C (en) | 2016-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |