MX2009012285A - Diacylglycerol acyltransferase inhibitors. - Google Patents

Diacylglycerol acyltransferase inhibitors.

Info

Publication number
MX2009012285A
MX2009012285A MX2009012285A MX2009012285A MX2009012285A MX 2009012285 A MX2009012285 A MX 2009012285A MX 2009012285 A MX2009012285 A MX 2009012285A MX 2009012285 A MX2009012285 A MX 2009012285A MX 2009012285 A MX2009012285 A MX 2009012285A
Authority
MX
Mexico
Prior art keywords
diacylglycerol acyltransferase
acyltransferase inhibitors
compounds
obesity
substituents
Prior art date
Application number
MX2009012285A
Other languages
Spanish (es)
Inventor
David Robert Bolin
Weiya Yun
Yimin Qian
Fariborz Firooznia
Lee Apostle Mcdermott
Adrian Wai-Hing Cheung
Matthew Michael Hamilton
Jenny Tan
Original Assignee
Via Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Via Pharmaceuticals Inc filed Critical Via Pharmaceuticals Inc
Publication of MX2009012285A publication Critical patent/MX2009012285A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
MX2009012285A 2007-05-22 2008-05-13 Diacylglycerol acyltransferase inhibitors. MX2009012285A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US93136907P 2007-05-22 2007-05-22
US93127307P 2007-05-22 2007-05-22
US93130307P 2007-05-22 2007-05-22
US93132707P 2007-05-22 2007-05-22
PCT/EP2008/055843 WO2008141976A1 (en) 2007-05-22 2008-05-13 Diacylglycerol acyltransferase inhibitors

Publications (1)

Publication Number Publication Date
MX2009012285A true MX2009012285A (en) 2009-12-15

Family

ID=39619031

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012285A MX2009012285A (en) 2007-05-22 2008-05-13 Diacylglycerol acyltransferase inhibitors.

Country Status (8)

Country Link
EP (1) EP2155687A1 (en)
CN (1) CN101835757B (en)
AU (1) AU2008253118B2 (en)
BR (1) BRPI0811947A2 (en)
CA (1) CA2686951C (en)
HK (1) HK1148519A1 (en)
MX (1) MX2009012285A (en)
WO (1) WO2008141976A1 (en)

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US7795283B2 (en) 2004-12-14 2010-09-14 Astrazeneca Ab Oxadiazole derivative as DGAT inhibitors
CN101346387A (en) 2005-12-22 2009-01-14 阿斯利康(瑞典)有限公司 Pyrimido- [4, 5-]-oxazines for use as DGAT inhibitors
PL2004607T3 (en) 2006-03-31 2012-03-30 Novartis Ag (4-(4-[6-(trifluoromethyl-pyridin-3-ylamino)-N-containing-heteroaryl]-phenyl)-cyclohexyl)-acetic acid derivatives and pharmaceutical uses thereof
CN101472905B (en) 2006-05-30 2011-12-14 阿斯利康(瑞典)有限公司 Substituted 5- phenylamino- 1, 3, 4-oxadiaz0l-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme a diacylglycerol acyltransferase
US8153644B2 (en) 2007-05-22 2012-04-10 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8058299B2 (en) 2007-05-22 2011-11-15 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8115011B2 (en) 2007-05-22 2012-02-14 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
JO2972B1 (en) * 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine/Piperazine derivatives
AU2008258560C1 (en) 2007-06-08 2014-04-10 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
EP2152270B1 (en) 2007-06-08 2015-03-04 Janssen Pharmaceutica, N.V. Piperidine/piperazine derivatives
EP2152271B1 (en) 2007-06-08 2015-10-21 Janssen Pharmaceutica, N.V. Piperidine/piperazine derivatives
AR066169A1 (en) 2007-09-28 2009-07-29 Novartis Ag DERIVATIVES OF BENZO-IMIDAZOLES, USEFUL FOR DISORDERS ASSOCIATED WITH THE ACTIVITY OF DGAT
ES2617619T3 (en) * 2008-06-05 2017-06-19 Janssen Pharmaceutica, N.V. Drug combinations comprising a DGAT inhibitor and a PPAR agonist
US8211884B2 (en) 2008-08-06 2012-07-03 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8324385B2 (en) 2008-10-30 2012-12-04 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8716312B2 (en) 2008-11-19 2014-05-06 Merck Sharp & Dohme Corporation Inhibitors of diacylglycerol acyltransferase
CN102239165A (en) * 2008-12-03 2011-11-09 维尔制药公司 Inhibitors of diacylglycerol acyltransferase
JP2012512252A (en) * 2008-12-17 2012-05-31 ブイアイエイ・ファーマシューティカルズ・インコーポレーテッド Inhibitors of diacylglycerol acyltransferase
EP2404902A1 (en) 2009-03-05 2012-01-11 Shionogi&Co., Ltd. Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
WO2011078102A1 (en) * 2009-12-22 2011-06-30 第一三共株式会社 Novel phenoxypyrimidine derivative
JP5925688B2 (en) * 2010-10-14 2016-05-25 田辺三菱製薬株式会社 Amide derivatives and uses thereof
TW201236685A (en) * 2010-11-11 2012-09-16 Daiichi Sankyo Co Ltd New pyrazole amide derivatives
US9453003B2 (en) * 2011-08-11 2016-09-27 Jikai Biosciences, Inc. Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
US9452995B2 (en) * 2011-08-11 2016-09-27 Jikai Biosciences, Inc. Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
US9458151B2 (en) * 2011-08-11 2016-10-04 Jikai Biosciences, Inc. Isothiazole derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
CN102924446B (en) 2011-08-11 2015-08-26 上海吉铠医药科技有限公司 PIM kinase inhibitor and preparation method thereof and the application in pharmacy
ES2618955T3 (en) 2012-04-13 2017-06-22 Mitsubishi Tanabe Pharma Corporation Amidopyridine derivative and use thereof
CN104672166A (en) * 2015-02-10 2015-06-03 佛山市赛维斯医药科技有限公司 Cyanophenyl thiazolecarboxylic acid amide double-target inhibitor containing amidine structure as well as preparation method and application of inhibitor
CN104710382A (en) * 2015-02-10 2015-06-17 佛山市赛维斯医药科技有限公司 Halogeneated phenyl thiazole carboxylic acid amides compounds containing tertiary butyl amidine structures and application
CN104557765A (en) * 2015-02-10 2015-04-29 佛山市赛维斯医药科技有限公司 Halophenyl thiazolecarboxylic acid amide double-target inhibitor containing amidine structure, as well as preparation method and application thereof
CN104672165B (en) * 2015-02-10 2016-06-01 佛山市赛维斯医药科技有限公司 One class is containing alkoxyphenyl radical thiazole carboxylic acid amides's class two target spot inhibitor, the Preparation Method And The Use of cyclopropyl amidine structure
CN104672164A (en) * 2015-02-10 2015-06-03 佛山市赛维斯医药科技有限公司 SGLT2/SGLT1 double-target inhibitor containing benzene amidine structure as well as preparation method and application of inhibitor
CN104610187B (en) * 2015-02-10 2016-04-06 佛山市赛维斯医药科技有限公司 One class is containing alkoxyphenyl radical thiazole carboxylic acid amides class two target spot inhibitor, the Preparation Method And The Use of amidine structure
CN104592151A (en) * 2015-02-10 2015-05-06 佛山市赛维斯医药科技有限公司 Tert-butyl amidine structure containing SGLT2/SGLT1 dual-target inhibitor and application thereof
CN104592149A (en) * 2015-02-10 2015-05-06 佛山市赛维斯医药科技有限公司 Tert-butyl amidine structure containing alkoxyphenyl thiazolecarboxylic acid amide dual-target inhibitor, as well as preparation method and application thereof
CN104610189A (en) * 2015-02-10 2015-05-13 佛山市赛维斯医药科技有限公司 SGLT2/SGLT1 double-target-point inhibitor containing cyclopropyl amidine structure and application of SGLT2/SGLT1 double-target-point inhibitor
HUE050986T2 (en) 2016-03-17 2021-01-28 Hoffmann La Roche 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
KR20200067850A (en) 2017-10-06 2020-06-12 포르마 세라퓨틱스 인크. Inhibition of ubiquitin-specific peptidase 30
RS64321B1 (en) 2018-10-05 2023-08-31 Forma Therapeutics Inc Fused pyrrolines which act as ubiquitin-specific protease 30 (usp30) inhibitors

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US7553867B2 (en) * 2002-09-06 2009-06-30 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
JP2008543747A (en) * 2005-06-11 2008-12-04 アストラゼネカ アクチボラグ Oxadiazole derivatives as DGAT inhibitors
JP5076091B2 (en) * 2005-11-28 2012-11-21 マドリガル・ファーマシューティカルズ・インコーポレーテッド Inhibitors of diacylglycerol acyltransferase (DGAT)

Also Published As

Publication number Publication date
CN101835757A (en) 2010-09-15
EP2155687A1 (en) 2010-02-24
AU2008253118A1 (en) 2008-11-27
CA2686951C (en) 2016-03-22
BRPI0811947A2 (en) 2014-11-11
CN101835757B (en) 2014-03-05
CA2686951A1 (en) 2008-11-27
WO2008141976A1 (en) 2008-11-27
AU2008253118B2 (en) 2013-11-21
HK1148519A1 (en) 2011-09-09

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