BRPI0818244A2 - Compound, pharmaceutical composition, use of a compound, and method for treating a disorder or disease - Google Patents
Compound, pharmaceutical composition, use of a compound, and method for treating a disorder or diseaseInfo
- Publication number
- BRPI0818244A2 BRPI0818244A2 BRPI0818244-2A BRPI0818244A BRPI0818244A2 BR PI0818244 A2 BRPI0818244 A2 BR PI0818244A2 BR PI0818244 A BRPI0818244 A BR PI0818244A BR PI0818244 A2 BRPI0818244 A2 BR PI0818244A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- disorder
- disease
- treating
- pharmaceutical composition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15607P | 2007-10-24 | 2007-10-24 | |
| US7256808P | 2008-04-01 | 2008-04-01 | |
| PCT/US2008/012039 WO2009054984A1 (en) | 2007-10-24 | 2008-10-23 | Heterocycle phenyl amide t-type calcium channel antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0818244A2 true BRPI0818244A2 (en) | 2015-06-16 |
Family
ID=40292437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0818244-2A BRPI0818244A2 (en) | 2007-10-24 | 2008-10-23 | Compound, pharmaceutical composition, use of a compound, and method for treating a disorder or disease |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8637513B2 (en) |
| EP (1) | EP2212291B1 (en) |
| JP (1) | JP5524071B2 (en) |
| KR (1) | KR20100072266A (en) |
| CN (1) | CN101910133A (en) |
| AU (1) | AU2008317353B2 (en) |
| BR (1) | BRPI0818244A2 (en) |
| CA (1) | CA2701594C (en) |
| IL (1) | IL205141A0 (en) |
| MX (1) | MX2010004530A (en) |
| RU (1) | RU2010120671A (en) |
| WO (1) | WO2009054984A1 (en) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2010493B1 (en) | 2006-04-12 | 2016-01-27 | Merck Sharp & Dohme Corp. | Pyridyl amide t-type calcium channel antagonists |
| AU2008317353B2 (en) | 2007-10-24 | 2014-08-07 | Merck Sharp & Dohme Llc | Heterocycle phenyl amide T-type calcium channel antagonists |
| US8927551B2 (en) | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US8765735B2 (en) | 2009-05-18 | 2014-07-01 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US9149465B2 (en) | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| KR101605061B1 (en) * | 2009-05-29 | 2016-03-21 | 라퀄리아 파마 인코포레이티드 | Aryl substituted carboxamide derivatives as calcium or sodium channel blockers |
| WO2011022315A1 (en) * | 2009-08-19 | 2011-02-24 | Merck Sharp & Dohme Corp. | Pyrazinyl phenyl amide t-type calcium channel antagonists |
| US8987310B2 (en) | 2009-10-30 | 2015-03-24 | Merck Sharp & Dohme Corp. | Heterocycle amide T-type calcium channel antagonists |
| AU2012278976B2 (en) | 2011-07-06 | 2017-05-11 | Gilead Sciences, Inc. | Compounds for the treatment of HIV |
| TWI694071B (en) * | 2013-03-01 | 2020-05-21 | 美商基利科學股份有限公司 | Therapeutic compounds for treating a retroviridae viral infection |
| WO2014134776A1 (en) * | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134774A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| EP2964221B1 (en) | 2013-03-04 | 2017-12-06 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134772A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| EP2997024B1 (en) | 2013-05-17 | 2018-03-28 | Boehringer Ingelheim International GmbH | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof |
| EP3013805B1 (en) | 2013-06-28 | 2018-02-21 | Evotec International GmbH | Sulfoximine substituted quinazolines and their use as mnk1 and/or mnk2 kinase inhibitors |
| US9443063B2 (en) * | 2013-12-06 | 2016-09-13 | President And Fellows Of Harvard College | Method and apparatus for using gait analysis to determine a health quality measure |
| AU2015270118C1 (en) | 2014-06-03 | 2019-11-28 | Idorsia Pharmaceuticals Ltd | Pyrazole compounds and their use as T-type calcium channel blockers |
| ES2693052T3 (en) | 2014-09-15 | 2018-12-07 | Idorsia Pharmaceuticals Ltd | Triazole compounds as blockers of the T-type calcium channels |
| MX2018004947A (en) | 2015-10-22 | 2018-11-09 | Cavion Inc | Methods for treating angelman syndrome and related disorders. |
| UY37367A (en) | 2016-08-19 | 2018-03-23 | Gilead Sciences Inc | NEW COMPOUNDS FOR USE IN THE TREATMENT OF A VIRAL INFECTION AND COMPOSITIONS OF THE SAME |
| HRP20220463T1 (en) | 2016-12-16 | 2022-05-27 | Idorsia Pharmaceuticals Ltd | Pharmaceutical combination comprising a t-type calcium channel blocker |
| MX2019009242A (en) | 2017-02-06 | 2019-09-13 | Idorsia Pharmaceuticals Ltd | A novel process for the synthesis of 1-aryl-1-trifluoromethylcycl opropanes. |
| US11130750B2 (en) | 2017-02-15 | 2021-09-28 | Cavion, Inc. | Calcium channel inhibitors |
| CN110770221B (en) | 2017-04-26 | 2023-09-08 | 卡维昂公司 | Methods for improving memory and cognition and for treating memory and cognition disorders |
| TW202024061A (en) | 2017-08-17 | 2020-07-01 | 美商基利科學股份有限公司 | Solid forms of an hiv capsid inhibitor |
| AR112412A1 (en) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | CHOLINE SALT FORMS OF AN HIV CAPSID INHIBITOR |
| EP3752495B1 (en) | 2018-02-15 | 2023-07-19 | Gilead Sciences, Inc. | Pyridine derivatives and their use for treating hiv infection |
| AR114631A1 (en) | 2018-02-16 | 2020-09-30 | Gilead Sciences Inc | METHODS AND INTERMEDIATES FOR PREPARING PYRIDINE COMPOUNDS |
| KR20210033492A (en) | 2018-07-16 | 2021-03-26 | 길리애드 사이언시즈, 인코포레이티드 | Capsid inhibitors for the treatment of HIV |
| CA3115235A1 (en) | 2018-10-03 | 2020-04-09 | Cavion, Inc. | Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| BR112022000429A2 (en) | 2019-07-11 | 2022-03-29 | Praxis Prec Medicines Inc | Formulations of t-type calcium channel modulators and methods of using them |
| KR20220106165A (en) | 2019-11-26 | 2022-07-28 | 길리애드 사이언시즈, 인코포레이티드 | Capsid inhibitors for the prevention of HIV |
| JP2023533915A (en) | 2020-06-25 | 2023-08-07 | ギリアード サイエンシーズ， インコーポレイテッド | Capsid inhibitor for treatment of HIV |
| CN114262322A (en) * | 2020-09-16 | 2022-04-01 | 中国科学院上海有机化学研究所 | Apoptosis inhibitor and preparation method and application thereof |
| KR20230167035A (en) * | 2021-03-04 | 2023-12-07 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | T-type calcium channel antagonists and uses thereof |
| PE20240767A1 (en) * | 2021-04-16 | 2024-04-17 | Hotspot Therapeutics Inc | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISORDERS |
| CA3235937A1 (en) | 2021-12-03 | 2023-06-08 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
| WO2024121046A1 (en) * | 2022-12-05 | 2024-06-13 | Angelini Pharma S.P.A. | Amide compounds as activators of the potassium channels kv7.2/kv7.3 useful in the treatment of cns and pns disorders |
| CN117357503B (en) * | 2023-12-08 | 2024-03-08 | 中国人民解放军军事科学院军事医学研究院 | Use of p-hydroxyphenylacetamide in the treatment of psychotic disorders |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2798075A (en) * | 1957-07-02 | Heterocyclic quaternary salts | ||
| GB782067A (en) | 1955-03-21 | 1957-08-28 | Hoffmann La Roche | Novel pyridinium salts and a process for the manufacture of same |
| US3505349A (en) * | 1966-04-18 | 1970-04-07 | Hoffmann La Roche | 2-nitro-imidazolyl-1-acetamides |
| US3594982A (en) * | 1970-04-20 | 1971-07-27 | Kaiser Aluminium Chem Corp | Process for drying unsaturated organic gaseous compounds |
| DE2150279C2 (en) | 1971-10-05 | 1983-08-25 | Schering AG, 1000 Berlin und 4709 Bergkamen | Blood sugar lowering sulfamoylpyrimidines with an asymmetric carbon atom |
| DE69222055T2 (en) | 1991-10-31 | 1998-03-19 | Abbott Lab | METHOD FOR PRODUCING FLUORINATED BENZOIC ACIDS |
| DE4443892A1 (en) * | 1994-12-09 | 1996-06-13 | Bayer Ag | 4- (Quinolin-2-yl-methoxy) phenyl acetic acid derivatives |
| DE19504379A1 (en) * | 1995-02-10 | 1996-08-14 | Hoechst Ag | Substituted benzenesulfonylureas and thioureas, processes for their preparation and their use in the manufacture of pharmaceutical preparations and pharmaceutical preparations containing them |
| DE19536378A1 (en) * | 1995-09-29 | 1997-04-03 | Bayer Ag | Heterocyclic aryl, alkyl and cycloalkyl acetic acid amides |
| FR2751970B1 (en) | 1996-08-01 | 1998-08-28 | Synthelabo | 6,7,8,9-TETRAHYDRO-5H-IMIDAZO [1,2-A] AZEPINE-3-ACETIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| AUPO252896A0 (en) | 1996-09-24 | 1996-10-17 | Fujisawa Pharmaceutical Co., Ltd. | Amidine derivatives |
| WO1998021185A1 (en) | 1996-11-08 | 1998-05-22 | Sankyo Company, Limited | Arylureas or arylmethylcarbamoyl derivatives |
| GB9828442D0 (en) * | 1998-12-24 | 1999-02-17 | Karobio Ab | Novel thyroid receptor ligands and method II |
| GB9919588D0 (en) | 1999-08-18 | 1999-10-20 | Hoechst Schering Agrevo Gmbh | Fungicidal compounds |
| JP4009460B2 (en) * | 2000-03-14 | 2007-11-14 | アクテリオン ファマシューティカルズ リミテッド | 1,2,3,4-tetrahydroisoquinoline derivative |
| UA75093C2 (en) * | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
| WO2002051232A2 (en) * | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| WO2002062778A2 (en) | 2001-02-02 | 2002-08-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anti-thrombotic compounds, production and use thereof as medicaments |
| US6610701B2 (en) | 2001-02-09 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
| US20020183519A1 (en) * | 2001-03-13 | 2002-12-05 | Herbert Nar | Antithrombotic carboxylic acid amides |
| AU2002242926B2 (en) | 2001-04-10 | 2007-10-11 | Pfizer Inc. | Pyrazole derivatives for treating HIV |
| GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| WO2003031443A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| US20030199523A1 (en) * | 2002-02-28 | 2003-10-23 | Snutch Terrance P. | Heterocyclic calcium in channel blockers |
| DE10209766B4 (en) * | 2002-03-05 | 2004-02-19 | Daimlerchrysler Ag | Component replacement warning system |
| TW200508197A (en) * | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
| GB0318422D0 (en) * | 2003-08-06 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
| US20070270428A1 (en) * | 2003-11-19 | 2007-11-22 | James Hagan | Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders |
| AU2004309357B2 (en) * | 2003-12-22 | 2010-10-07 | Merck Sharp & Dohme Corp. | Alpha-hydroxy amides as bradykinin antagonists or inverse agonists |
| EP1776106B1 (en) * | 2004-06-22 | 2013-08-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives for modulation of calcium channels |
| DE102004041137A1 (en) | 2004-08-25 | 2006-03-02 | Wella Ag | o-aminophenol derivatives and colorants containing these compounds |
| NZ553646A (en) * | 2004-09-22 | 2010-07-30 | Janssen Pharmaceutica Nv | Inhibitors of the interaction between MDM2 and p53 |
| CN101228129A (en) | 2005-04-20 | 2008-07-23 | 詹森药业有限公司 | Fluorinated pyridine N-oxide thrombin modulators and process for N-oxidation of nitrogen containing heteroaryls |
| CA2611153A1 (en) * | 2005-06-23 | 2007-01-04 | Merck & Co., Inc. | 3-fluoro-piperidine t-type calcium channel antagonists |
| RU2440988C2 (en) * | 2005-07-26 | 2012-01-27 | Санофи-Авентис | CYCLOHEXYLAMINIZOQUINOLONE AS Rho-KINASE INHIBITORS |
| EP1760072A1 (en) | 2005-08-30 | 2007-03-07 | Wella Aktiengesellschaft | 1,3-diaminobenzene derivatives and colorants comprising these compounds |
| EP1762218A1 (en) | 2005-08-30 | 2007-03-14 | Wella Aktiengesellschaft | 4-aminophenol derivatives and colorants comprising these compounds |
| WO2007075852A2 (en) * | 2005-12-22 | 2007-07-05 | Icagen, Inc. | Calcium channel antagonists |
| AU2006327181A1 (en) | 2005-12-22 | 2007-06-28 | Hydra Biosciences, Inc. | TRPA1 inhibitors for treating pain |
| EP2010493B1 (en) * | 2006-04-12 | 2016-01-27 | Merck Sharp & Dohme Corp. | Pyridyl amide t-type calcium channel antagonists |
| ME02372B (en) * | 2006-11-22 | 2016-06-20 | Incyte Holdings Corp | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
| JP2011500808A (en) | 2007-10-24 | 2011-01-06 | メルク・シャープ・エンド・ドーム・コーポレイション | Heterocyclic amide T-type calcium channel antagonist |
| AU2008317353B2 (en) | 2007-10-24 | 2014-08-07 | Merck Sharp & Dohme Llc | Heterocycle phenyl amide T-type calcium channel antagonists |
| AU2008317351A1 (en) | 2007-10-24 | 2009-04-30 | Merck Sharp & Dohme Corp. | Pyrazinyl amide T-type calcium channel antagonists |
| WO2009057784A1 (en) * | 2007-11-01 | 2009-05-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP2659933A1 (en) * | 2008-01-25 | 2013-11-06 | Torrent Pharmaceuticals Ltd. | Pharmaceutical combinations comprising specified age breaker and further drugs, i.a. antihypertensive drugs, antidiabetic drugs etc. |
| US20090291967A1 (en) * | 2008-03-05 | 2009-11-26 | Adherex Technologies, Inc. | Small molecule modulators of cell adhesion |
| DE102008053369A1 (en) * | 2008-10-27 | 2010-04-29 | Giesecke & Devrient Gmbh | A method for challenge-response authentication between a reader and a transponder based on a contactless data transmission |
| WO2010076566A2 (en) * | 2008-12-30 | 2010-07-08 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| US20120016119A1 (en) * | 2009-01-22 | 2012-01-19 | Yasunori Tsuboi | NOVEL PYRROLO(2,3-d)PYRIMIDINE COMPOUND |
| JP2012517448A (en) * | 2009-02-11 | 2012-08-02 | リアクション バイオロジー コープ． | Selective kinase inhibitor |
| PE20120655A1 (en) * | 2009-02-17 | 2012-06-07 | Chiesi Farma Spa | TRIAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINES ACTIVATED BY MITOGEN P38 (MAP) |
| JPWO2010101164A1 (en) * | 2009-03-05 | 2012-09-10 | 第一三共株式会社 | Pyridine derivatives |
| US20110319379A1 (en) * | 2009-03-11 | 2011-12-29 | Corbett Jeffrey W | Substituted Indazole Amides And Their Use As Glucokinase Activators |
| TW201102387A (en) * | 2009-06-08 | 2011-01-16 | Medicinova Inc | Substituted pyrazolo[1,5-a]pyridine compounds having multi-target activity |
| US8324212B2 (en) * | 2010-02-25 | 2012-12-04 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
-
2008
- 2008-10-23 AU AU2008317353A patent/AU2008317353B2/en active Active
- 2008-10-23 RU RU2010120671/04A patent/RU2010120671A/en not_active Application Discontinuation
- 2008-10-23 JP JP2010531034A patent/JP5524071B2/en active Active
- 2008-10-23 WO PCT/US2008/012039 patent/WO2009054984A1/en active Application Filing
- 2008-10-23 KR KR1020107008475A patent/KR20100072266A/en not_active Application Discontinuation
- 2008-10-23 EP EP08843270.3A patent/EP2212291B1/en active Active
- 2008-10-23 BR BRPI0818244-2A patent/BRPI0818244A2/en not_active IP Right Cessation
- 2008-10-23 US US12/739,294 patent/US8637513B2/en active Active
- 2008-10-23 MX MX2010004530A patent/MX2010004530A/en not_active Application Discontinuation
- 2008-10-23 CN CN2008801233321A patent/CN101910133A/en active Pending
- 2008-10-23 CA CA2701594A patent/CA2701594C/en active Active
-
2010
- 2010-04-15 IL IL205141A patent/IL205141A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2701594C (en) | 2014-02-18 |
| MX2010004530A (en) | 2010-05-14 |
| AU2008317353B2 (en) | 2014-08-07 |
| JP5524071B2 (en) | 2014-06-18 |
| US20100261724A1 (en) | 2010-10-14 |
| EP2212291B1 (en) | 2014-06-04 |
| CN101910133A (en) | 2010-12-08 |
| WO2009054984A1 (en) | 2009-04-30 |
| KR20100072266A (en) | 2010-06-30 |
| JP2011500809A (en) | 2011-01-06 |
| CA2701594A1 (en) | 2009-04-30 |
| US8637513B2 (en) | 2014-01-28 |
| EP2212291A1 (en) | 2010-08-04 |
| RU2010120671A (en) | 2011-11-27 |
| IL205141A0 (en) | 2010-11-30 |
| AU2008317353A1 (en) | 2009-04-30 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |