BRPI0811333A2 - "proteína de fusão compreendida de taci truncado e de imunoglobulina fc, sequência de dna, vetor, célula, uso da proteína de fusão e composição farmacêutica" - Google Patents

"proteína de fusão compreendida de taci truncado e de imunoglobulina fc, sequência de dna, vetor, célula, uso da proteína de fusão e composição farmacêutica"

Info

Publication number
BRPI0811333A2
BRPI0811333A2 BRPI0811333-5A BRPI0811333A BRPI0811333A2 BR PI0811333 A2 BRPI0811333 A2 BR PI0811333A2 BR PI0811333 A BRPI0811333 A BR PI0811333A BR PI0811333 A2 BRPI0811333 A2 BR PI0811333A2
Authority
BR
Brazil
Prior art keywords
fusion protein
vector
cell
pharmaceutical composition
dna sequence
Prior art date
Application number
BRPI0811333-5A
Other languages
English (en)
Inventor
Zheng Liu
Jianmin Fang
Original Assignee
Yantai Rongchang Biotechnologies Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yantai Rongchang Biotechnologies Co Ltd filed Critical Yantai Rongchang Biotechnologies Co Ltd
Publication of BRPI0811333A2 publication Critical patent/BRPI0811333A2/pt
Publication of BRPI0811333B1 publication Critical patent/BRPI0811333B1/pt
Publication of BRPI0811333B8 publication Critical patent/BRPI0811333B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
BRPI0811333A 2007-06-15 2008-06-16 proteína de fusão compreendida de taci truncado e de imunoglobulina fc, sequência de dna, vetor, microrganismo transgênico, uso da proteína de fusão, e composição farmacêutica BRPI0811333B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH200710111162.2 2007-06-15
CN2007101111622A CN101323643B (zh) 2007-06-15 2007-06-15 优化的TACI-Fc融合蛋白
PCT/CN2008/001162 WO2008154814A1 (en) 2007-06-15 2008-06-16 OPTIMIZED TACI-Fc FUSION PROTEINS

Publications (3)

Publication Number Publication Date
BRPI0811333A2 true BRPI0811333A2 (pt) 2015-06-16
BRPI0811333B1 BRPI0811333B1 (pt) 2020-09-15
BRPI0811333B8 BRPI0811333B8 (pt) 2021-05-25

Family

ID=40155884

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0811333A BRPI0811333B8 (pt) 2007-06-15 2008-06-16 proteína de fusão compreendida de taci truncado e de imunoglobulina fc, sequência de dna, vetor, microrganismo transgênico, uso da proteína de fusão, e composição farmacêutica

Country Status (8)

Country Link
US (1) US8193316B2 (pt)
EP (1) EP2161287B1 (pt)
JP (1) JP5372917B2 (pt)
KR (1) KR101204229B1 (pt)
CN (1) CN101323643B (pt)
BR (1) BRPI0811333B8 (pt)
RU (1) RU2433141C2 (pt)
WO (1) WO2008154814A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201120210A (en) 2009-11-05 2011-06-16 Hoffmann La Roche Glycosylated repeat-motif-molecule conjugates
IN2013MN01394A (pt) * 2011-01-06 2015-06-12 Complix Nv
CN102085368B (zh) * 2011-01-19 2013-06-12 烟台荣昌生物工程有限公司 优化的TACI-Fc融合蛋白用于制备治疗系统性红斑狼疮药物的应用
CN102085367B (zh) * 2011-01-19 2012-08-22 烟台荣昌生物工程有限公司 优化的TACI-Fc融合蛋白用于制备治疗类风湿性关节炎药物的应用
CN103833856B (zh) * 2012-11-22 2017-05-03 上海康岱生物医药技术股份有限公司 抑制taci‑baff复合物形成的融合蛋白及其制法和用途
CN103936833B (zh) * 2014-04-18 2016-02-10 天津大学 BLyS拮抗肽、含TC-Fc融合蛋白基因的质粒及TC-Fc融合蛋白
WO2018236995A2 (en) 2017-06-20 2018-12-27 Dana-Farber Cancer Institute, Inc. METHODS FOR MODULATING REGULATORY T LYMPHOCYTES, REGULATORY B LYMPHOCYTES AND IMMUNE RESPONSES USING AVRIL-TACI INTERACTION MODULATORS
CN110522908A (zh) * 2018-05-25 2019-12-03 荣昌生物制药（烟台）有限公司 TACI-Fc融合蛋白用于制备治疗视神经脊髓炎谱系疾病和多发性硬化之药物中的应用
BR112021025458A2 (pt) * 2019-12-10 2022-06-21 Remegen Co Ltd Formulação farmacêutica, método de preparação e uso da mesma
JP2022539785A (ja) 2019-12-24 2022-09-13 レメゲン シーオー．，エルティーディー． ＴＡＣＩ－Ｆｃ融合タンパク質及びその用途
AU2021268033A1 (en) 2020-05-08 2022-12-15 Alpine Immune Sciences, Inc. APRIL and BAFF inhibitory immunomodulatory proteins with and without a T cell inhibitory protein and methods of use thereof
CN115073607A (zh) * 2021-03-12 2022-09-20 上海康岱生物医药技术股份有限公司 Tnfr2与baff受体的融合蛋白
CA3237992A1 (en) * 2021-03-31 2022-10-06 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Truncated taci polypeptide and fusion protein and use thereof
EP4333869A1 (en) 2021-05-07 2024-03-13 Alpine Immune Sciences, Inc. Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein
WO2022258045A1 (zh) * 2021-06-11 2022-12-15 山东先声生物制药有限公司 抗人il-17抗体和taci的双功能融合蛋白分子
BR112023018745A2 (pt) 2021-08-10 2024-03-12 Remegen Co Ltd Método para tratar nefropatia por iga com proteína de fusão de taci-fc
CN117916273A (zh) * 2021-09-30 2024-04-19 江苏恒瑞医药股份有限公司 抗il23抗体融合蛋白及用途
JP2024512935A (ja) 2021-09-30 2024-03-21 レメゲン シーオー．，エルティーディー． ＴＡＣＩ－Ｆｃ融合タンパク質を用いたシェーグレン症候群の治療方法
TW202334225A (zh) * 2021-11-11 2023-09-01 大陸商江蘇恆瑞醫藥股份有限公司 抗ｉｃｏｓｌ抗體融合蛋白及用途
CA3236667A1 (en) 2022-06-08 2023-12-14 Jianmin Fang Method for treating myasthenia gravis with taci-fc fusion protein
WO2024046301A1 (zh) * 2022-08-29 2024-03-07 江苏恒瑞医药股份有限公司 包含taci多肽的融合蛋白及其用途
WO2024067756A1 (zh) * 2022-09-30 2024-04-04 荣昌生物制药(烟台)股份有限公司 用TACI-Fc融合蛋白治疗膜性肾病的方法
WO2024077018A2 (en) 2022-10-04 2024-04-11 Alpine Immune Sciences, Inc. Methods and uses of taci-fc fusion immunomodulatory protein
WO2024114777A1 (zh) * 2022-12-02 2024-06-06 荣昌生物制药(烟台)股份有限公司 用TACI-Fc融合蛋白治疗微小病变型肾病的方法
WO2024120458A1 (zh) * 2022-12-07 2024-06-13 荣昌生物制药(烟台)股份有限公司 TACI-Fc融合蛋白液体药物制剂

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
AU2001253920B2 (en) * 2000-04-27 2006-03-16 Apoxis Sa Use of taci as an anti-tumor agent
KR20040030628A (ko) * 2001-05-24 2004-04-09 지모제넥틱스, 인코포레이티드 Ｔａｃｉ-면역글로불린 융합 단백질
MX2007005378A (es) * 2004-11-04 2008-02-14 Genentech Inc Polipeptidos que ligan a baff y/o april.
EP1922079A2 (en) * 2005-08-09 2008-05-21 ZymoGenetics, Inc. Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
CN100471872C (zh) * 2005-11-04 2009-03-25 余波 包含vegf受体片段的优化融合蛋白质及其医疗应用

Also Published As

Publication number Publication date
EP2161287A1 (en) 2010-03-10
CN101323643A (zh) 2008-12-17
WO2008154814A1 (en) 2008-12-24
KR101204229B1 (ko) 2012-11-26
JP2010529967A (ja) 2010-09-02
BRPI0811333B8 (pt) 2021-05-25
EP2161287A4 (en) 2010-08-11
BRPI0811333B1 (pt) 2020-09-15
US8193316B2 (en) 2012-06-05
JP5372917B2 (ja) 2013-12-18
RU2433141C2 (ru) 2011-11-10
EP2161287B1 (en) 2015-03-04
KR20100009600A (ko) 2010-01-27
US20100136008A1 (en) 2010-06-03
RU2009148020A (ru) 2011-07-10
CN101323643B (zh) 2010-12-01

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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