BRPI0709596A2 - compostos bicicloeteroarila como moduladores de p2x7 e seus usos - Google Patents

compostos bicicloeteroarila como moduladores de p2x7 e seus usos Download PDF

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Publication number
BRPI0709596A2
BRPI0709596A2 BRPI0709596-1A BRPI0709596A BRPI0709596A2 BR PI0709596 A2 BRPI0709596 A2 BR PI0709596A2 BR PI0709596 A BRPI0709596 A BR PI0709596A BR PI0709596 A2 BRPI0709596 A2 BR PI0709596A2
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Prior art keywords
substituted
unsubstituted
compound according
formula
disorders
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BRPI0709596-1A
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English (en)
Portuguese (pt)
Inventor
Michael G Kelly
John Kincaid
Yunfeng Fang
Yeyu Cao
Carl Kaub
Sumithra Gowlugari
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Renovis Inc
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Publication of BRPI0709596A2 publication Critical patent/BRPI0709596A2/pt

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/12Antidiarrhoeals
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
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  • Ophthalmology & Optometry (AREA)
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BRPI0709596-1A 2006-03-16 2007-03-16 compostos bicicloeteroarila como moduladores de p2x7 e seus usos BRPI0709596A2 (pt)

Applications Claiming Priority (29)

Application Number Priority Date Filing Date Title
US78297306P 2006-03-16 2006-03-16
US78292206P 2006-03-16 2006-03-16
US78292306P 2006-03-16 2006-03-16
US78312106P 2006-03-16 2006-03-16
US78278206P 2006-03-16 2006-03-16
US78359006P 2006-03-16 2006-03-16
US78330406P 2006-03-16 2006-03-16
US78277606P 2006-03-16 2006-03-16
US78278106P 2006-03-16 2006-03-16
US78374806P 2006-03-16 2006-03-16
US78277506P 2006-03-16 2006-03-16
US60/782,923 2006-03-16
US60/783,748 2006-03-16
US06/783,121 2006-03-16
US06/783,304 2006-03-16
US60/782,781 2006-03-16
US60/782,973 2006-03-16
US60/782,775 2006-03-16
US06/782,782 2006-03-16
US60/783,590 2006-03-16
US60/782,922 2006-03-16
US60/782,776 2006-03-16
US83141606P 2006-07-17 2006-07-17
US60/831,416 2006-07-17
US84699306P 2006-09-25 2006-09-25
US60/846,993 2006-09-25
US91808607P 2007-03-15 2007-03-15
US60/918,086 2007-03-15
PCT/US2007/006685 WO2007109160A2 (en) 2006-03-16 2007-03-16 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0709596A2 true BRPI0709596A2 (pt) 2011-07-19

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Application Number Title Priority Date Filing Date
BRPI0709596-1A BRPI0709596A2 (pt) 2006-03-16 2007-03-16 compostos bicicloeteroarila como moduladores de p2x7 e seus usos

Country Status (9)

Country Link
US (1) US8779144B2 (enExample)
EP (1) EP1937643B1 (enExample)
JP (1) JP5306986B2 (enExample)
BR (1) BRPI0709596A2 (enExample)
CA (1) CA2645551C (enExample)
DK (1) DK1937643T3 (enExample)
ES (1) ES2596532T3 (enExample)
MX (1) MX2008011919A (enExample)
WO (1) WO2007109160A2 (enExample)

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JP2010520875A (ja) * 2007-03-09 2010-06-17 レノビス, インコーポレイテッド P2x7調節因子としてのビシクロヘテロアリール化合物およびその使用
JP2011509296A (ja) * 2008-01-09 2011-03-24 レノビス, インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体およびそれを使用する薬学的組成物および方法
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CN112079769A (zh) * 2008-04-23 2020-12-15 里格尔药品股份有限公司 用于治疗代谢障碍的甲酰胺化合物
CA2744383C (en) 2008-11-21 2017-04-25 High Point Pharmaceuticals, Llc Adamantyl benzamide compounds
WO2010118921A1 (en) 2009-04-14 2010-10-21 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
JP2013526496A (ja) 2010-05-14 2013-06-24 アフェクティス ファーマシューティカルズ アーゲー P2x7r拮抗剤の新規調製方法
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
JP5955957B2 (ja) 2011-07-22 2016-07-20 アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd P2x7受容体アンタゴニストとしての複素環アミド誘導体
US9409917B2 (en) 2012-01-20 2016-08-09 Actelion Pharmaceuticals Ltd. Heterocyclic amide derivatives as P2X7 receptor antagonists
TWI612034B (zh) 2012-12-12 2018-01-21 愛杜西亞製藥有限公司 作爲p2x7受體拮抗劑之吲哚羧醯胺衍生物
US9556117B2 (en) 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
ES2616114T3 (es) 2013-01-22 2017-06-09 Actelion Pharmaceuticals Ltd. Derivados de amida heterocíclica como antagonistas del receptor P2X7
CN104918946B (zh) 2013-01-22 2017-03-29 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的杂环酰胺衍生物
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶-1,6(2h,7h)-二酮
WO2023179542A1 (en) * 2022-03-21 2023-09-28 Gasherbrum Bio , Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes

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DK1937643T3 (en) 2016-10-10
EP1937643A2 (en) 2008-07-02
ES2596532T3 (es) 2017-01-10
WO2007109160A9 (en) 2007-11-15
WO2007109160A2 (en) 2007-09-27
EP1937643A4 (en) 2010-03-10
JP2009530302A (ja) 2009-08-27
MX2008011919A (es) 2008-11-28
WO2007109160A3 (en) 2008-05-02
US8779144B2 (en) 2014-07-15
CA2645551A1 (en) 2007-09-27
US20110118287A1 (en) 2011-05-19
JP5306986B2 (ja) 2013-10-02
CA2645551C (en) 2016-06-28

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