BRPI0708708A2 - polipeptìdeio tendo não mais do que 100 aminoácidos, polipeptìdeo imunogênico de epìtopo múltiplo, composição de polipeptìdeo, método para produzir um polipeptìdeo, construção de polipeptìdeo, método para produzir a mesma, composição de vacina ou medicamento contra um vìrus hiv, método para produzir uma composição de vacina ou medicamento, uso de um polipeptìdeo, uma composição de polipeptìdeo, uma construção de polipeptìdeo ou uma composição de vacina ou medicamento - Google Patents

Abstract

POLIPEPTìDEO TENDO NãO MAIS DO QUE 100 AMINOáCIDOS, POLIPEPTìDEO IMUNOGêNICO DE EPìTOPO MULTIPLO, COMPOSIçãO DE POLIPEPTìDEO, MéTODO PARA PRODUZIR UM POLIPEPTìDEO, CONSTRUçãO DE POLIPEPTìDEO, METODO PARA PRODUZIR A MESMA, COMPOSIçãO DE VACINA OU MEDICAMENTO CONTRA UM VìRUS HIV, METODO PARA PRODUZIR UMA COMPOSIçãO DE VACINA OU MEDICAMENTO, USO DE UM POLIPEPTìDEO, UMA COMPOSIçãO DE POLIPEPTìDEO, UMA CONSTRUçãO DE POLIPEPTìDEO OU UMA COMPOSIçãO DE VACINA OU MEDICAMENTO. E fornecido um polipeptídeo tendo não mais do que 100 aminoácidos, polipeptídeo este que compreende uma ou mais sequências tendo pelo menos 60% de homologia com qualquer uma das SEQ ID 1 a 4, ou compreende dois ou mais epítopos tendo 7 aminoácidos ou mais, cada epítopo tendo pelo menos 60% de homologia com uma sub-sequência de qualquer uma das SEQ ID 1 a 4 que tem o mesmo comprimento como o epítopo: SEQ ID 1 GDTWAGVEAHRILQQLLFT HIFRIGCQHSR; SEQ ID 2 KVGSLQYLALTAIITPKKJKYPLPSVKKL TEDRWNKPQKT; SEQ TD 3 EPVPLQLPPLERLTLDCSEDCGTSGT Q; SEQ ID 4 YKGALDLSHTLKEKGGLEGLIYSQKRQDILDLWVYIT TQGYFPD em que, o polipeptídeo é imunogênico em um vertebrado que expressa um alelo de complexo de histocompatibilidade maior (MHC), e em que o polipeptídeo não é uma proteína do vírus HIV completa.

Description

"POLIPEPTÍDEO TENDO NÃO MAIS DO QUE 100 AMINOÁCIDOS,

POLIPEPTÍDEO IMUNOGÊNICO DE EPÍTOPO MÚLTIPLO,

COMPOSIÇÃO DE POLIPEPTÍDEO, MÉTODO PARA PRODUZIR UM

POLIPEPTÍDEO, CONSTRUÇÃO DE POLIPEPTÍDEO, MÉTODO PARA

PRODUZIR A MESMA, COMPOSIÇÃO DE VACINA OUMEDICAMENTO CONTRA UM VÍRUS HIV, MÉTODO PARAPRODUZIR UMA COMPOSIÇÃO DE VACINA OU MEDICAMENTO,USO DE UM POLIPEPTÍDEO, UMA COMPOSIÇÃO DE POLIPEPTÍDEO,UMA CONSTRUÇÃO DE POLIPEPTÍDEO OU UMA COMPOSIÇÃO DEVACINA OU MEDICAMENTO"

A invenção diz respeito a seqüências de peptídeo, composiçõesque compreendem as seqüências de peptídeo, e em particular vacinas contra ovírus da imunodeficiência, tais como vacinas contra o vírus daimunodeficiência humana (HIV) e/ou outros vírus da imunodeficiência quetambém podem ser úteis contra a síndrome da imunodeficiência adquirida(AIDS). As vacinas compreendem as seqüências e as composições. Ainvenção também diz respeito aos usos das seqüências e composições. Amesma especialmente diz respeito às vacinas que são protetoras contra umapluralidade de cepas virais, incluindo os vírus existentes assim como os vírusfuturos que tenham mutado a partir dos vírus existentes (tais como as formasmutadas de uma cepa do HIV existente).

A defesa contra doença é crítica para a sobrevivência de todosos animais, e o mecanismo de defesa utilizado para este propósito é o sistemaimune do animal. Entender o sistema imune é portanto uma chave para odesenvolvimento de novos e mais sofisticados tratamentos para sereshumanos e animais semelhantes.

O mecanismo de operação do sistema imune tem estado sobinvestigação por muitos anos. O sistema é composto de vários tipos de célulae uma variedade de moléculas, tornando-o extremamente complexo. Mesmodepois de muitos anos de estudo, a extensão completa dos componentes dosistema imune, e a sua interação um com o outro, são imperfeitamenteentendidas.

A muitos anos atrás foi reconhecido que uma pessoa que serecupera de uma doença particular pode adquirir alguma proteção no futurocontra esta doença, mas não contra uma doença que esta pessoa ainda nãocontraiu. Este aspecto fundamental do sistema imune foi interpretado naqueletempo pela consideração de que o sistema imune adquiriu um tipo de'memória' contra certos patógenos uma vez que a exposição a tais patógenostivesse ocorrida, esta memória sendo específica para uma certa doença.

Gradualmente, tornou-se conhecido que a exposição avariantes menos nocivas de um patógeno poderia induzir proteção contra asvariantes mais nocivas (por exemplo, a exposição à varíola bovina paraproteger contra a varíola, ou exposição a um antraz inativado para protegercontra o antraz vivo). Assim, a idéia de vacinação contra uma doença surgiu.

É agora conhecido que o sistema imune tem pelo menos duasdivisões: a imunidade inata e a imunidade adaptiva. O sistema inato étotalmente funcional antes que um patógeno entra no sistema, enquanto que osistema adaptivo é ligado depois que o patógeno entra no sistema. Este depoisdesenvolve um ataque específico para o patógeno. O sistema inatocompreende vários componentes, incluindo fagócitos tais como macrófagos,que (como o nome sugere) 'come' ou engolfa corpos estranhos tais comopatógenos.

Tipicamente, mas não exclusivamente, a presente invençãoestá relacionada com o sistema imune adaptivo, e a menos queespecificamente de outro modo indicado, o 'sistema imune' no presentecontexto refere-se ao sistema imune adaptivo.

De modo a entender mais completamente como o sistemaimune funciona, o papel de seus componentes individuais deve sercuidadosamente considerado. Em relação ao sistema imune adaptivo, é bemconhecido que a imunidade contra patógenos é fornecida pela ação delinfócitos, que constituem o tipo de célula mais comum no sistema imune.Existem dois tipos de linfócito: o linfócito Beo linfócito T. Estes são nogeral chamados de células B e células T, respectivamente.

As células B têm a capacidade para se desenvolver em célulasplasmáticas, que fabricam anticorpos. Os anticorpos são componentes muitoimportantes do sistema imune do animal. Estes são produzidos em resposta aalguma porção de assinatura do patógeno invasor (um antígeno do patógeno -antígenos aqui sendo definido como qualquer substância estranha reconhecidopelo sistema imune) e são usualmente específicos para este patógeno.

Entretanto, se dois patógenos são muito similares, ou pelo menos contêm omesmo antígeno, então os anticorpos produzidos contra um não obstante podeser eficaz contra o outro (eles podem 'reagir cruzado'). Isto explica porque ainoculação com varíola bovina pode proteger contra a varíola. E importantecompreender que os anticorpos 'reconhecem' apenas uma pequena porção damolécula antigênica do patógeno ao invés do patógeno como um todo. Estasporções são chamadas de epítopos.

As células T não possuem ou produzem anticorpos. Ao invés,elas reconhecem fragmentos (isto é, epítopos) do antígeno estranhocomplexados com o complexo de histocompatibilidade maior (MHC) (ou nocaso de seres humanos, antígeno de leucócito humano (HLA)) por intermédiode um receptor especializado conhecido como TCR (receptor de célula T). Ascélulas T são elas próprias divisíveis em subconjuntos que podem ter umafunção regulatória ou uma função efetora. As células efetoras estãoenvolvidas com o 'efetuar' a remoção das substâncias estranhas. Por exemplo,as células T citotóxicas (CTL) são células efetoras que são capazes de matarcélulas infectadas, assim como outras espécies indesejadas tais como célulasde tumor. As células T reguladoras, por outro lado, desempenham um papelem ajudar as células TeB efetoras a se tornarem mais eficazes. Devido a estafunção, estas células T reguladoras são freqüentemente chamadas de células T'auxiliares'. Outras células T reguladoras, chamadas de células T'supressora', são consideradas inibir respostas imunes, mas estas são menosbem entendidas. As células T reguladoras também podem interagir comcomponentes do sistema imune inato para reforçar a sua atividade.

Em um indivíduo saudável normal, os linfócitos no sistemaimune permanecem em um estado de "repouso' inativo até que uma respostaimune seja deflagrada. Quando uma resposta imune é requerida, os linfócitosse tornam ativadas, proliferam e começam a realizar as suas funçõesdesignadas. Por exemplo, qualquer célula T em repouso que demonstra na suasuperfície um TCR que reconhece um epítopo do patógeno invasorcomplexado com uma molécula MHC é ativada, prolifera (isto sendochamado de expansão clonal) e a progênie resultante começa a realizarativamente as suas funções efetoras pré determinadas requeridas paracombater os organismos invasores.

Quando a resposta imune é completada, (isto é, os patógenose/ou células infectadas foram eliminados) os linfócitos revertem mais uma veza um estado de repouso. Este estado de repouso não é, entretanto, equivalenteao estado de repouso inativo inicial. Os linfócitos ativados, mas em repouso, podem ser rapidamente recrutados e induzidos a proliferar em resposta a umainfecção pelo mesmo patógeno, ou um intimamente relacionado, em umtempo posterior.

Esta capacidade dos linfócitos ativados em repouso, paraliberar uma resposta mais rápida e mais poderosa a seguir de um segundoencontro com um patógeno invasor, eficazmente provê o sistema imune com'memória'. A utilização da memória do sistema imune é a base para todos osmedicamentos imunoprofiláticos de longa duração (por exemplo, vacinas) epermanece a meta de todo desenvolvimento de medicamentoimunoterapêutico de longa duração.De modo que as células realizem as suas funções dentro dosistemas complexo de um animal, as células precisam ter 'receptores' nas suassuperfícies. Estes receptores são capazes de 'reconhecer' substânciasespecíficas que controlam vários processos essenciais tais como a ativação,proliferação e aderência a outras células ou substratos. Por exemplo, no casodo sistema imune, os receptores nas células TeB permitem que elas nãoapenas reconheçam antígeno mas também interajam entre si e assim regulemsuas atividades. Sem estes receptores, as células careceriam de um meioessencial de comunicação e seriam incapazes de atuar eficazmente no modocombinado que é essencial para o sistema imune de um organismomulticelular.

De modo a ser capaz de reconhecer especificamente e lidarcom a ampla faixa de patógenos presentes no ambiente, o sistema imunedesenvolveu dois tipos de receptor de antígeno altamente variável noslinfócitos: anticorpos em células B e receptores em célula T, ou TCRs5 emcélulas T.

Existe muitos receptores de antígeno diferentes possíveispresentes no corpo, para permitir que o sistema imune reconheça uma amplavariedade de patógenos invasores. De fato existem aproximadamente 10^12receptores de célula B e célula T diferentes em um indivíduo. Cada célula Bindividual tem apenas um tipo de receptor, e assim para lidar com umpatógeno particular, uma célula B tendo o receptor 'que melhor se ajusta' paraum antígeno deste patógeno deve ser selecionada. Este processo é chamado de'seleção clonal'. Em teoria, apenas um único clone pode responder (umaresposta monoclonal) ou diversos (uma resposta oligoclonal) ou muitos (umaresposta policlonal) dependendo do número de antígenos/epítopos exibidospelo patógeno, e da especificidade das várias células B selecionadas para estesantígenos/epítopos.

Existe uma diferença maior entre os tipos de antígeno quepodem ser reconhecidos pelas células B e células T. Até agora como éconhecido, apenas os receptores na superfície dos linfócitos B (isto é, osanticorpos) são capazes de reconhecer diretamente antígenos tais como asproteínas nos vírus e bactérias ou moléculas estranhas dissolvidas no fluidocorporal. Os anticorpos também podem ser produzidos em uma forma solúvelpelas células B quando elas são ativadas e desenvolvem em célulasplasmáticas. Os anticorpos também são chamados de imunoglobulinas(abreviado para Ig). Os receptores de célula T, por outro lado, reconhecemapenas peptídeos curtos, também conhecidos como epítopos de célula T, nasuperfície das células do corpo. Estes epítopos de célula T são produzidospela degradação de proteínas maiores que são próprias (isto é, proteínas docorpo que ocorrem naturalmente) ou não próprias (isto é, derivadas deorganismos estranhos que infetam o corpo). Apenas aqueles derivados deproteínas estranhas, isto é, antígenos, são normalmente capazes de induziruma resposta imune no corpo. Uma vez produzidos, estes epítopos são ligadosa um tipo especial de molécula, o MHC (complexo de histocompatibilidademaior) e o complexo resultante é depois apresentado na superfície da célulapara ligar o receptor de célula T.

Deve estar claro que devido à natureza destrutiva da respostaimune, a resposta tem que atuar apenas contra patógenos estranhos, nãocontra as células ou proteínas do próprio corpo. Assim, o sistema imuneprecisa distinguir entre próprio e não próprio. Tem sido proposto que emboraos clones de linfócitos que reagem contra o próprio corpo sejam produzidos,eles são deletados antes que qualquer reação possa ocorrer. Este processo échamado de 'deleção clonal'. Também tem sido proposto que quaisquerlinfócitos que reajam contra o próprio corpo podem ser retidos mas apenas emum estado 'desligado'. Este mecanismo é chamado de 'anergia clonal'.Qualquer que seja o processo considerado, permanece incerto qual é omecanismo subjacente exato que permite que os tecidos linfóides, tais como otimo, identifique os clones de célula T individuais que reagem contra opróprio corpo do agrupamento de linfócitos T que reagem apenas contra opróprio corpo. Os presentes inventores têm agora investigado maiscompletamente o mecanismo de discriminação própria/não própria, que temlevado ao desenvolvimento da presente invenção. Os inventoresestabeleceram agora um método de prognosticar a imunogenicidade de umasubstância tal como um peptídeo, que tem permitido a identificação maisrápida de seqüências imunogênicas de peptídeo dentro das proteínas grandes.

Foi conhecido por muitos anos que o complexo dehistocompatibilidade maior (MHC) desempenha um papel chave no sistemaimune de animais. As moléculas do MHC permitem que as células Treconheçam antígenos, como já foi debatido acima. Existem três tipos geraisde molécula MHC5 classe I, classe II e classe III. As moléculas MHC declasse I e classe II são glicoproteínas que estão presentes na superfície dacélula, enquanto que a classe III são usualmente moléculas solúveis presentesdentro da célula. Existe um grande número de tipos diferentes de moléculaMHC. Por exemplo nos seres humanos (onde o MHC é chamado de HLA ouAntígeno de Leucócito Humano) existem várias centenas de alelos diferentesdos genes que codificam as moléculas MHC, significando que na populaçãohumana existem muitos tipos diferentes de HLA. Os MHCs de espéciesdiferentes são tipicamente chamadas de acordo com convenções diferentes,assim o MHC para camundongo é chamado de H-2, para rato RTl e paracoelho RLA. As regiões de genes diferentes que codificam moléculas MHCdiferentes em um indivíduo são denominadas de modo usualmente individual,tais como HLA-A, HLA-C etc. em seres humanos.

A molécula de MHC é uma molécula do sistema imune crítica,visto que é esta molécula que apresenta os epítopos dos antígenos ao sistemaimune. Por exemplo, se uma célula T deve responder a um patógenoparticular, o patógeno deve ter pelo menos um antígeno (tal como umaproteína) que tenha pelo menos um epítopo (tal como uma porção de peptídeoda proteína) que possa ligar a uma molécula de MHC na superfície de umacélula e assim interagir com uma célula T que liga ao complexo de MHC-peptídeo. Assim, a resposta imune é dependente da capacidade do MHC paraligar a um epítopo. Se não existe nenhum epítopo que o MHC ligar-se-á ou senão existe nenhuma célula T que ligar-se-á ao complexo de MHC-peptídeo,então nenhuma resposta imune ocorrerá.

Com respeito às 'auto' proteínas, entretanto, um de váriosepítopos pode ser capaz de ligar à molécula de MHC e conseqüentementeinduzir potencialmente uma resposta imune. Nestas ocasiões um "sinal"específico deve ser fornecido para que os clones de linfócito auto-reativossejam deletados ou "desligados".

Visto que, como indicado acima, os peptídeos tanto própriosquanto estranhos (isto é, não próprios) podem se ligar às moléculas de MHC,a ligação de vários peptídeos às moléculas de MHC tem recebido exameminucioso particular no campo da imunologia. Muitas investigações têmprocurado calcular ou predizer a força de ligação entre certos tipos de MHC(particularmente HLA e H-2) e as seqüências de peptídeo, para tentaresclarecer quanto as respostas imunes ou a falta delas (i.e. o "sinal" requeridopara a discriminação entre próprio e estranho). Os exemplos destas incluem asseguintes:

Altuvia Y, Schueler O, Margalit H. 1995. "Ranking potentialbinding peptides to MHC molecules by a computational threading approach".J. Mol. Biol., 249: 244-250.

Altuvia Y, Sette A, Sidney J, Southwood S, Margalit H. 1997."A structure-based algorithm to predict potential binding peptides to MHCmolecules with hydrophobic binding pockets". Hum. Immunol. 58: 1-11.

G. E. Meister, C. G. P. Roberts, J. A. Berzofsky, A. S. DeGroot, "Two novel T cell epitope prediction algorithms based on MHC-binding motifs; comparison of predicted and published epitopes fromMycobacterium tuberculosis and HTV protein sequences" Vaccine, 13: 581-591,(1995).

Gulukota K, Sidney J, Sette A, DeLisi C. 1997. "Twocomplementary methods for predicting peptides binding majorhystocompatibility eomplex molecules". J. Mol. Biol. 267: 1258-1267.

Pamer EG, Harty JT, Bevan MJ. "Precise prediction of adominant class I MHC-restricted epitope of Listeria monocytogenes". Nature1991; 353: 852-855.

Parker KC, Bednarek MA, Coligan JE. 1994. "Scheme forranking potential HLA-A2 binding peptides based on independent binding ofindividual peptide side-chains". J. Immunol. 152: 163-175.

Rammensee HG, Friede T, Stevanoviic S. 1995. "MHCligands and peptide motifs: First listing". Immunogenetics 41: 178-228.

Ruppert J, Sidney J, Celis E, Kubo RT, Grey HM5 Sette A.1993. "Prominent role of secondary anchor residues in peptide binding toHLA-A2.1 molecules". Cell 74: 929-937.

Schueler-Furman O, Elber R, Margalit H. 1998. "Knowledge-based structure prediction of MHC class I bound peptides: A study of 23complexes". Fold Des. 3: 549-564.

Sette A, Buus S, Appella E, Smith JA, Chesnut R, Miles C,Colon SM, Grey HM. 1989. "Prediction of major hystocompatibility eomplexbinding regions of protein antigens by sequence pattern analysis". Proc. Natl.Acad. Sei. USA 86: 3296-3300.

Sette A, Sidney J, dei Guercio MF, Southwood S, Ruppert J,Dahlberg C, Grey HM, Kubo RT. 1994a. "Peptídeo binding to the mostfrequent HLA-A class I alleles measured by quantitative molecular bindingassays". Mol. Immunol. 31: 813-822.

Sette A, Vitiello A, Rehennan B, Fowler P, Nayersina R, KastWM5 Melief CJM, Oseroff C, Yuan L, Ruppert J, et al. 1994b. "Therelationship between class I binding affinity and imunogenicity of potentialcytotoxic T cell epitopes". J. Immunol. 153: 5586-5592.

Stefan Stevanovic (2002): "Structural basis of imunogenicity",TransplantImmunology 10 133-136

Sturniolo T, Bono E, Ding J, Raddrizzani L, Tuereci O, SahinU, Braxenthaler M, Gallazzi F, Protti MP, Sinigaglia F, Hammer J. 1999."Generation of tissue-specific and promiscuous HLA ligand databases usingDNA microarrays and virtual HLA class II matrices". Nat. Biotechnol. 17:555-561.

T. Sudo, N. Kamikawaji, A. Kimura, Y. Date, C. J. Savoie, H.Nakashima, E. Furuichi, S. Kuhara, e T. Sasazuki, "Differences in MHCClass I self peptide repertoires among HLA-A2 subtypes." J. Immunol.: 155:4749_4756, (1995).

T. Tana, N. Kamikawaji, C. J. Savoie, T. Sudo, Y. Kinoshita,T. Sasazuki, "A HLA binding motif-aided peptide epitope library: A novellibrary design for the screening of HLA-DR4- restricted antigenic peptidesrecognized by CD4+ cells T." J. Human Genet., 43: 14-21 (1998).

K. Falk, et al. "Allele-specific motifs revealed by sequencingof self-peptides eluted from MHC molecules", Nature, Vol. 351, 290-297(1991).

T Elliott et ai. "Peptide-induced conformational change of theclass I heavy chain", Nature, Vol. 351, 402-407, (1991).

P. Parham, "Deconstructing the MHC", Nature, Vol. 360, 300-301,(1992).

Hwai-Chen Guo et al., "Different length peptides bind toHLA-Aw68 similarly at their ends but bulge out in the middle", Nature, Vol.360, 364-367, (1992).

Y. Chen et al. "Naturally processed peptides longer than nineamino acid residues bind to the class I MHC molecule HLA-A2.1 com highaffinity and in different conformations", J. Immunol., 152, 2874-2881, (1994).

D. F. Hunt et ai. "Characterização of peptides bound to theclass I MHC molecule HLA-A2.1 by mass spectrometry", Science, VoL 255,1261-1263,(1992).

No geral, a técnica anterior tenta prognosticar aimunogenicidade de peptídeos particulares pelo cálculo da força de ligaçãoentre este peptídeo e o ambiente de ligação conhecido de uma molécula deMHC particular. O ambiente de ligação envolve uma 'bolsa' na molécula deHC que é adaptada para aceitar um peptídeo de um certo comprimento (talcomo 7 a 15 aminoácidos). A estrutura da bolsa já pode ser conhecida deestudos cristalográficos de raio X anteriores. Esta força pode ser calculadamatematicamente usando algoritmos apropriados para a interação atômica emolecular. Alternativamente, a técnica anterior pode tentar 'contar' a força deligação de um peptídeo com base em motivos existentes no peptídeo, taiscomo aminoácidos particulares que estão presentes em posições particularesem um peptídeo de um certo comprimento, por exemplo, uma prolinapresente na posição 3 em um peptídeo de 8 aminoácidos que se liga a umamolécula de HLA particular conhecida. No geral estes métodos têm atingidosucesso limitado.

Os presentes inventores acreditam que possam ter melhoradonas teorias acima a partir de um melhor entendimento de como as células Treagem contra substâncias próprias tais como as proteínas próprias sãoidentificadas antes da sua eliminação (deleção clonal) ou silenciamento(anergia clonal). Conseqüentemente, os inventores foram capazes deidentificar seqüências de peptídeo imunogênicas específicas que podemfornecer proteção contra patógenos específicos, e desenvolveram vacinas paraestes patógenos, usando as seqüências identificadas. No caso da presenteinvenção, os inventores desenvolveram peptídeos úteis em vacinas do HTVque evocam uma resposta de célula T.

Por muitos anos a infecção pelo HIV não foi uma condiçãosuscetível de tratamento. Quando a doença foi identificada em 1981, asterapias anti-virais existentes foram ineficazes em controlar o dano que ovírus poderia causar a uma sistema imune do paciente. O vírus causa adestruição direta e indireta das células T CD4 positivas, que são essenciaispara um funcionamento completo do sistema imune. Conforme uma contagemde célula T CD4+ do paciente diminui, a doença se torna progressivamentepior. Quando a contagem de célula T CD4+ cai abaixo de certo nível, opaciente é considerado ter deteriorado até o ponto de ter AIDS completamentedesenvolvida. As definições do ponto em que isto ocorre varia, mas no geral éconsiderado que é atingido em pessoas HIV positivas saudáveis com umacontagem de célula T CD4 + de menos do que 200 por ml de sangue. Maisrecentemente, as terapias anti-virais têm melhorado, e a progressão da doençatem sido consideravelmente diminuída. As terapias combinatórias modernas(em alguns pacientes) podem retardar o início da AIDS completamentedesenvolvida indefinidamente. Entretanto, estas terapias são caras, e colocauma carga sobre o paciente requerendo que ele ou ela tome um númerosignificante de tabletes por dia (muitos pacientes acham difícil lembrar detomar os remédios requeridos) e em muitos casos levando a efeitos colateraisdesagradáveis (não surpreendente quando se toma um coquetel contendomuitos produtos farmacêuticos diferentes, que devem ser tomados para o restoda vida). Não apenas as terapias correntes sofrem destes problemas, mas elasnão são curativas, meramente retardam o início da AIDS completamentedesenvolvida. Além disso, em anos recentes houve um número aumentado derelatos indicando o aparecimento e disseminação de medicamentos contra oHIV resistente a medicamento. Conseqüentemente, existe uma necessidadereal e urgente quanto a uma vacina que pudesse prevenir e/ou curar os vírusda imunodeficiência, tais como HIV, e também prevenir e/ou curar a AIDS.Anteriormente, tentativas para se desenvolver vacinas contra aHIV têm sido feitas pela identificação de uma cepa do HTV existente e depoisproduzindo uma vacina específica para aquele vírus. No geral, as vacinasforam fundamentadas em uma resposta de B célula (anticorpo), o anticorpoque é reativo com os antígenos de superfície da cepa do HTV específica contraa qual a mesma foi desenvolvida. Tipicamente, as proteínas de superfície quecompreendem os antígenos são variáveis de uma cepa do HTV para a seguinte,visto que a mutação do vírus para produzir um novo vírus tende a ocorrer nasproteínas de superfície. A conseqüência disto é que as vacinas contra o HIVconvencionais, se elas fossem funcionais de qualquer modo, no geralprotegeriam apenas contra uma cepa viral específica, e não contra uma novacepa que resulta de uma mutação. Assim, uma nova vacina seria requeridapara a proteção contra uma cepa emergente. O período de tempo entre aemergência da nova cepa viral pela mutação é muito curto. Dentro de umindivíduo infectado novas cepas estão surgindo todo o tempo, como umresultado da pressão seletiva imposta por aquele sistema imune do indivíduo.Como um resultado, a população viral encontrada em um indivíduo infectadomuda com o tempo (em um período de semanas, meses e anos) sem qualquerexigência para a re-infecção divido à lata taxa de mutação. Assim, o únicocaminho provável para alvejar a infecção por vírus da imunodeficiência emum indivíduo ou para alvejar novas cepas virais potenciais que poderiaminfectar ou desenvolver em um indivíduo, é alvejar uma região conservada doproteoma. Este método é inerentemente problemático, visto que a respostaimune dominante para o HIV está direcionada às seções que estão elaspróprias sob uma alta taxa de mutação, devido (a) à pressão imunológica e (b)às taxas de fidelidade baixa do mecanismo replicativo do vírus.

Vários estudos direcionados ao desenvolvimento de vacinaspara os vírus da imunodeficiência (incluindo vacinas para o HIV) foramempreendidos no passado. Estes foram na maior parte fundamentados emanticorpo e concentrados em vacinas com base na glicoproteína 120 eglicoproteína 160 do HIV (considerados ser os melhores candidatos para umavacina contra o HTV). Particularmente estudos relevantes são listados nosseguintes:

Blood. 7 de fevereiro de 2006; "HTV nonprogressorspreferentially maintain highly functional HlV-specific CD8+ T-cells". BettsMR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, LedermanMM, Benito JM, Goepfert PA, Connors M, Roederer M, Koup RA.

Indian J Med Res. Abril de 2005; 121(4): 287-314. "Impact ofgenetic diversity of HIV-I on diagnosis, antiretroviral therapy & vaccinedevelopment". Lal RB, Chakrabarti S, Yang C.

J Virol. Abril de 2005; 79(8): 4580-8. "Vaccine-elicitedmemory cytotoxic T lymphocytes contribute to Mamu-A*01-associatedcontrol of simian/human immunodeficiency viras 89.6P replication in rhesusmonkeys". Seaman MS, Santra S, Newberg MH, Philippon V, Manson K, XuL, Gelman RS, Panicali D, Mascola JR, Nabel GJ, Letvin NL.

J Infect Dis. 1 de Março de 2005; 191(5): 666-77. Epub 27 deJaneiro de 2005. "Correlation between immunologic responses to arecombinant glycoprotein 120 vaccine and incidence of HIV-I infection in aphase 3 HIV-I preventive vaccine trial". Gilbert PB, Peterson ML, FollmannD, Hudgens MG, Francis DP, Gurwith M, Heyward WL, Jobes DV, PopovicV, Self SG, Sinangil F, Burke D, Berman PW.

J Infect Dis. 1 de Março de 2005; 191(5): 654-65. Epub 27 deJaneiro de 2005. "Placebo-controlled phase 3 trial of a recombinantglycoprotein 120 vaccine to prevent HIV-I infection". Flynn NM, ForthalDN, Harro CD, Judson FN5 Mayer KH, Para MF.

J Exp Med. 21 de Junho de 2004; 199(12): 1709-18."Cytotoxic T lymphocyte-based control of simian immunodeficiency virusreplication in a preclinical AIDS vaccine trial". Matano T, Kobayashi M,Igarashi Η, Takeda Α, Nakamura Η, Kano Μ, Sugimoto C, Mori Κ, Iida A5Hirata Τ, Hasegawa Μ, Yuasa Τ, Miyazawa Μ, Takahashi Υ, Yasunami Μ,Kimura Α, O'Connor DH3 Watkins DI, Nagai Υ.

Immunol Res. 2004; 29(1-3): 161-74. "Insights into the role ofhost genetic and T-cell factors in resistance to HTV transmission from studiesof highly HTV-exposed Thais". McNicholl JM, Promadej N.

J. Virol. Dez de 2005; 9(24): 15368-75: "Genetic andStochastic influences on the interaction of human immunodeficiency virustype 1 e cytotoxic T lymphocytes in identical twins". Yang 00, Church J,Kitehen CM, Kilpatriek R, Ali A, Geng Y, Killian MS, Sabado RL, Ng H,Suen J, Bryson Y, Jamieson BD, Krogstad P.

J. Virol. Setembro de 2005. 79 (17): 11523-8. "Humanimmunodeficiency virus mutations during the first month of infection arepreferentially found in known cytotoxic T-Iymphocyte epitopes". BernardinF, Kong D, Peddada LjBaxter-Lowe LA, Delwart E

Entretanto, embora os epítopos conhecidos tenham sidoextensivamente estudados, nenhum foi ainda satisfatório para formar a basede uma vacina do HIV. Além disso, as vacinas com base em qualquer epítopoúnico, mesmo se ela fosse para fornecer alguma proteção, provavelmenteseria específica para um HLA particular, tornando a vacina ineficaz em umagrande proporção da população humana.

Conseqüentemente, é um objetivo da presente invençãoresolver os problemas associados com a técnica anterior conhecida comoapresentados acima. É ainda um objetivo da presente invenção fornecer umpolipeptídeo que seja capaz de evocar uma resposta imune CTL emvertebrados contra uma pluralidade de cepas virais da imunodeficiência e/ouem uma pluralidade de indivíduos que expressam MHCs diferentes (HLAs). Eum outro objetivo da presente invenção fornecer uma vacina de vírus daimunodeficiência (tal como uma vacina do HIV) usando o polipeptídeo dainvenção. Preferivelmente a vacina é capaz de proteção contra umapluralidade de cepas virais e/ou é eficaz em uma pluralidade de indivíduosque expressam MHCs diferentes (HLAs).

Conseqüentemente, a presente invenção fornece umpolipeptídeo tendo não mais do que 100 aminoácidos, polipeptídeo este quecompreende uma ou mais seqüências tendo pelo menos 60 % de homologiacom qualquer uma das SEQ ID 1 a 4 ou compreende dois ou mais epítopostendo 7 aminoácidos ou mais, cada epítopo tendo pelo menos 60 % dehomologia com uma sub-seqüência de qualquer uma das SEQ ID 1 a 4 quetem o mesmo comprimento como o epítopo:

SEQ ID 1 GDTWAGVEAIIRILQQLLFIEFRIGCQHSRSEQ ID 2 KVGSLQYLALTALITPKKIKPPLPSVKXLTEDRWNKPQKTSEQ ID 3 EPVPLQLPPLERLTLDCSEDCGTSGTQSEQ ID 4 YKGALDLSHFLKEKGGLEGLIYS

QKRQDILDLWVYHTQGYFPD

em que, o polipeptídeo é imunogênico em um vertebrado queexpressa um alelo de complexo de histocompatibilidade maior (MHC), e emque o polipeptídeo não é uma proteína do vírus HIV completa.

Assim, o polipeptídeo é um que pode compreender o todo de(ou pode compreender pelo menos duas partes de 7 ou mais resíduos)qualquer uma das seqüências acima, mas não pode ter mais do que 100resíduos de aminoácido no total. O polipeptídeo também deve serimunogênico em um vertebrado que expressa um alelo MHC (HLA em sereshumanos). Um polipeptídeo imunogênico é entendido no presente contextosignificar um polipeptídeo que evoca uma resposta imune em um vertebrado,tal como pela ligação a uma MHC de vertebrado e fazendo com que a mesmareaja com um linfócito de célula T citotóxico. Um método para determinar seum polipeptídeo possui imunogenicidade é apresentado no Experimento 1abaixo. Entretanto, a presente invenção não é limitada a tais métodos, e apessoa habilitada pode selecionar qualquer método conhecido para determinara imunogenicidade, como desejado.

Como mencionado acima, o polipeptídeo pode ser um quecompreende dois epítopos de 7 ou mais resíduos que reagem com uma oumais MHCs e assim evocam uma resposta CTL ampla. A resposta pode serem um único indivíduo ou pode ser em pelo menos dois indivíduos diferentes(os indivíduos podem ser da mesma espécie ou de espécie diferente). Assim, opolipeptídeo pode compreender pelo menos dois epítopos de 7 ou maisresíduos diferentes, cada um dos quais individualmente fornece uma respostaa um paciente diferente. Um epítopo no contexto da presente invenção é umaparte de um polipeptídeo que é capaz de ligar a um MHC em um vertebrado,preferivelmente evocar uma resposta imune, tal como fazendo com que ocomplexo de MHC-epítopo reaja com um CTL. Um método para determinarse um polipeptídeo é um epítopo é apresentado no Experimento 1 abaixo.Entretanto, a presente invenção não é limitada a tais métodos, e a pessoahabilitada pode selecionar qualquer método conhecido para determinar se umpolipeptídeo é um epítopo, como desejado.

Os presentes inventores verificaram que as seqüências acimacompreendem uma pluralidade de epítopos CTL, que podem proporcionarproteção contra os vírus da imunodeficiência, especialmente o HIV, para umaampla variedade de vertebrados em uma população, e para um amplo gruporepresentativo da população humana. Além disso, os inventores analisaramtodas as seqüências de cepas do HIV conhecidas, e verificaram que asseqüências especificadas são acentuadamente conservadas através de todas ascepas do HIV conhecidas. Como tal, estas seqüências são muito improváveisde serem significantemente alteradas em novas cepas que resultem damutação de cepas existentes. Conseqüentemente, os epítopos dentro destasseqüências que fornecem proteção são altamente prováveis de estarempresentes em forma inalterada em novas cepas, visto que a mutaçãonormalmente não ocorre nestas regiões. Conseqüentemente, estes epítoposfornecem excelente oportunidade não apenas para fornecer proteção contra ascepas do HIY existentes (tais como as cepas de referência, por exemplo, nocaso do HTV-I Ciado B, a referência padrão HXB-2 - mais informação sobreas cepas de referência pode ser encontrada na base de dados http://hiv-web.lanl.gov), mas também proteção contra cepas até agora desconhecidas,tais como formas mutadas das cepas de referência acima.

Como debatido acima, as seqüências foram identificadasdepois da análise de todas as seqüências de cepa do HTV conhecidas. Asseqüências são assim seqüências de consenso desenvolvidas a partir da análiseacima. A despeito de serem seqüências de consenso, as seqüências em algunscasos correspondem exatamente às seqüências naturais em algumas das cepasdo HIV conhecidas. Devido à conservação extraordinária nas seqüênciasatravés de todos os vírus, as seqüências de consenso, mesmo quando diferindodas seqüências reais, apenas diferem em um pequeno número de resíduos, eassim contêm muitos epítopos menores (8-mers, 9-mers, 10-mers etc.) para osquais não existem diferenças das seqüências naturais. As seqüências deconsenso acima como um todo assim contêm muitos epítopos eficazes quesão os mesmos como os epítopos naturais, assim como epítopos eficazes quediferem apenas levemente dos epítopos naturais. Estará evidente para a pessoahabilitada que a invenção estende-se não apenas às seqüências de consenso eseus epítopos, mas também às seqüências reais correspondentes em quaisquercepas do vírus da imunodeficiência (por exemplo, HIV). Assim, as seqüênciascom alguma homologia com as seqüências de consenso também estão dentrodo escopo da invenção. Tal homologia permite a substituição, por exemplo,de até 3 aminoácidos em um epítopo de 8 mer (62,5 % de homologia) ou emum epítopo de 9-mer, 10-mer ou 11-mer. É preferido que não mais do que 10de tais substituições sejam identificáveis em uma seqüência da invenção quecorresponde às seqüências completas das SEQ ID 1 a 4 (66,6 % de homologiapara uma 30-mer). Tais substituições são preferivelmente substituiçõesconservativas em linha com esquemas de substituição conhecidos.

Tendo em mente que a invenção estende-se da seqüência deconsenso para as seqüências naturais correspondentes, então a invençãotambém fornece um polipeptídeo tendo não mais do que 100 aminoácidos,polipeptídeo este que compreende uma ou mais seqüências definidas pelosseguintes resíduos de aminoácido de uma proteína do vírus HIV oucompreende dois ou mais epítopos tendo 7 aminoácidos ou mais de umaseqüência definida pelos seguintes resíduos de aminoácido de uma proteínado vírus HIV:

resíduos 51 a 80 de uma proteína VPR

resíduos 142 a 181 de uma proteína VLF

resíduos 69 a 95 de uma proteína REV

resíduos 81 a 123 de uma proteína NEF

em que, o polipeptídeo é imunogênico em um vertebrado queexpressa um alelo de complexo de histocompatibilidade maior (MHC)5 e emque o polipeptídeo não é uma proteína do HIV completa.

A numeração de seqüência aludida na presente invenção édefinida de acordo com princípios bem reconhecidos. Assim, a numeraçãocomeça em 1 a partir do códon de início de tradução (ATG) reconhecido. Istocorresponde a uma Metionina (M), para o segmento do genoma do vírus HIVque codifica a proteína de interesse. Em outras palavras, a mesma começa em1 em relação à Metionina mostrada como o primeiro aminoácido na seqüênciade proteína de interesse como usado e definido pelas bases de dados nas quaisas seqüências foram apresentadas (isto é, GenBank, SwissProt, etc.).

A presente invenção será descrita em mais detalhes por via deexemplo apenas com referência às seguintes Figuras, em que:

A Figura 1 mostra a produção de IFN-γ pelas culturas deesplenócito primárias de camundongos vacinados com HIV-v e NRPestimulados com Con A (10 μ g/ml), Lisozima solúvel (5 μΕ/πιΙ),polipeptídeos solúveis purificados (PI, P2, P3 e P4; 5 μ^Ι) e célulashumanas Tl emparelhadas (Tl) e JURKAT desemparelhadas (Ju) com HLAtransfectadas com Lisozima, PI, P2, P3 ou P4 de acordo com o protocolodescrito no texto (a razão de esplenócito para célula transfectada é 10:1); aprodução de IFN-γ é representada como o diferencial entre o nível deprodução em resposta ao antígeno considerado menos a IFN-γ produzido emresposta à Lisozima solúvel ou à célula correspondente transfectada comLisozima. Os níveis de fundo de produção mediada por Lisozima de IFN-γforam para antígeno solúvel 25 ± 10 pg/ml, para antígeno em Tl 316 ± 43pg/ml, e para antígeno em Jurkat 19 ± 6 pg/ml;

A Figura 2 mostra a produção de IFN-γ pelas culturas deesplenócito primárias de camundongos vacinados com HIV-v e NRPestimulados com Con A (10 μg/ml), Lisozima solúvel (5 μg/ml), soluçãoequimolar purificada de proteínas do HIV recombinantes (51,1, g/ml) ecélulas humanas Tl emparelhadas (Tl) e JURKAT desemparelhadas (Ju) comHLA transfectadas com Lisozima ou solução equimolar purificada deproteínas do HIV recombinantes de acordo com o protocolo descrito no texto(a razão de esplenócito para célula transfectada é de 10:1); a produção deIFN-γ é representada como o diferencial entre o nível de produção emresposta ao antígeno considerado menos a IFN-γ produzida em resposta àLisozima solúvel ou à célula correspondente transfectada com Lisozima; osníveis de fundo da produção mediada por Lisozima de IFN-γ foram para oantígeno solúvel 25 ± 10 pg/ml, para o antígeno em Tl 316 ± 43 pg/ml, e parao antígeno em Jurkat 19 ± 6 pg/ml.

A Figura 3 mostra a produção de IFN-γ similar como para asFigures 1 e 2 em respeito ao grupo de teste 3, confirmando a reatividade dopeptídeo da SEQ ID 3;

A Figure 4 mostra a produção de IFN-γ similar como para asFigures 1 e 2 em respeito ao grupo de teste 4, confirmando a reatividade dopeptídeo da SEQ ED 4;

A Figure 5 mostra a produção de IFN-γ similar como para asFigures 1 e 2 em respeito ao grupo de teste 5, confirmando a reatividade dosantígenos derivados das proteínas VIF, REV e NEF HTV completas; e

A Figure 6 mostra a produção de IFN-γ pelas culturas deesplenócito primárias de camundongos vacinados com HTV-v e NRP-vestimulados com Ionomicina (0,78 μg/ml) e PMA (0,05 μg/ml), Con A (5μg/ml) ou células humanas CEM emparelhadas com HLA infectadas comisolados do HIV-I do Glado D (UG21-R5) ou Glado A (LTG-29-X4) deacordo com o protocolo descrito nos Exemplos (a razão de esplenócito paracélula infectada é de 10:1). A produção de IFN-γ é representada como, onúmero de células que produzem IFN-γ no grupo HIV-v menos o número decélulas que produzem IFN-γ no grupo NRP-v. O número de valores de célulasque produzem IFN-γ para os esplenócitos tanto de HTV-v quanto de NRP-vestimulados com Con A ou Ionomicina e PMA foram acima de 4900 e acimade 8000 respectivamente. A significância estatística foi estabelecida pelaanálise de Mann-Whitney não paramétrica dos valores de IFN-γ estabelecidospara os grupos HTV-v e NRP-v.

Os polipeptídeos da invenção descritos acima tipicamentecompreendem um ou mais (preferivelmente dois ou mais). Estes epítopos sãopreferivelmente epítopos de célula T, tais como epítopos de linfócito Tcitotóxicos (CTL). No geral o polipeptídeo é imunogênico a uma cepa dovírus da imunodeficiência (preferivelmente HIV), e preferivelmente a umapluralidade de tais cepas. No presente contexto, um polipeptídeo imunogênicoa uma cepa do vírus da imunodeficiência é entendido significar umpolipeptídeo que é parte de uma proteína viral e que evoca uma respostaimune, tal como pela exibição da reatividade de CTL quando ligado a umMHC. Um método para determinar se um polipeptídeo possui talimunogenicidade é apresentado no Experimento 1 abaixo. Entretanto, apresente invenção não é limitada a tais métodos, e a pessoa habilitada podeselecionar qualquer método conhecido para determinar imunogenicidade,como desejado.

Na presente invenção, o polipeptídeo compreende duas oumais seqüências como descritas acima. Tipicamente, duas, três, quatro, cincoou mais de tais seqüências podem estar presentes no polipeptídeo, sedesejado. Quanto mais tais epítopos estão presentes, maior a amplitude deproteção proporcionada dentro de uma população de seres humanos e/ouanimais individuais com HLAs ou MHCs divergentes.

O polipeptídeo de acordo com a presente invenção tambémpode compreender uma ou mais seqüências adicionais que não são epítopos,se desejado. Tipicamente as seqüências adicionais são de uma ou maisproteínas virais da imunodeficiência (preferivelmente proteínas do HTV).Estas seqüências podem estar situadas entre duas ou mais das seqüências (osepítopos) descritas acima, e/ou podem estar situadas em uma ou ambas asextremidades do polipeptídeo. A presença de tais seqüências adicionais nãodevem afetar a função do polipeptídeo, contanto que o polipeptídeo como umtodo não se torne muito grande, que interfira com a apresentação dos epítoposno sistema imune do vertebrado. Em formas de realização específicas dainvenção, quando o polipeptídeo é homólogo à SEQ ID 1, as seqüênciasadicionais são preferivelmente uma ou mais de uma proteína VPR(preferivelmente de uma cepa do HIV), quando o polipeptídeo é homólogo àSEQ ID 2, as seqüências adicionais são preferivelmente uma ou mais de umaproteína VIF (preferivelmente de uma cepa do HIV), quando o polipeptídeo éhomólogo à SEQ ID 3, as seqüências adicionais são preferivelmente uma oumais de uma proteína REV (preferivelmente de uma cepa do HIV), e quandoo polipeptídeo é homólogo à SEQ ID 4, as seqüências adicionais sãopreferivelmente uma ou mais de uma proteína NEF (preferivelmente de umacepa do HIV).

Nas formas de realização mais preferidas, as seqüênciasadicionais das proteínas mencionadas acima são aquelas dentro das seguintesseqüências de consenso ou aquelas tendo pelo menos 60 % de homologia comuma seqüência dentro das seguintes seqüências de consenso:

VPR HIV Consenso — SEQ DD 5MEQAPEDQGPQREPYNE WTLELLEELKNEAVRHFPRPWLHGLGQfflYETYGDTWAGVEABRILQQLLFIHFRIGCQHSRIGIIRQRRARNGASRSVIF HIV Consenso - SEQ ID 6MENRWQVMIVWQVDRIVIR1RTWKSLVKHHMYISKKAKGWFYRHHYESTHPRISSEVHIPLGDDAKLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQ VDPDLADQLIHLYYFDCFSESAIRKAILGHIVSPRCEYQAGHl^VGSLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQKTKGHRGSHTMNGHREV HIV Consenso - SEQ ID 7

MAGRSGDSDEELLKAVRI1KIL YQSNP YPSPEGTRQARRNRRRRWRARQRQIRSISERILSTCLGRPAEPVPLQLPPLERLTLDCSEDCGTSGTQQSQGTEEGVGSPQILVESPTVLESGTKENEF HIV Consenso - SEQ ID 8MGGKWSKSSWGWPAVRERMRRAEPAAEGVGAVSRDLEKHGAITSSNTAANNADCAWLEAQEEEEVGFPVRPQVPLRPMTYKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPDWQNYTPGPORYPLTFGWCFKL VPVEPEKVEEANEGENNCLLHPMSQHGMEDPEREVLVWKFDSRLAFHHMARELHPEYYKDC

A homologia aludida acima em relação às seqüências épreferivelmente de 75 %, 85 %, 95 % ou substancialmente 100 %.

Na presente invenção, a cepa do vírus da imunodeficiência nãoé especialmente limitada, e os polipeptídeos podem ser imunogênicos contra,e/ou derivada de, qualquer cepa do vírus HIV conhecida. As cepas futuras quetenham mutado de qualquer uma destas cepas existentes também podem seraquelas contra as quais os polipeptídeos são imunogênicos ou das quais ospolipeptídeos são derivados.

As seqüências que definem os polipeptídeos da presenteinvenção são situadas dentro das proteínas VPR, VIF, REV e NEF dequalquer cepa do vírus HIV (as seqüências de consenso das quais para todasas seqüências analisadas ou alternativamente as posições das quais dentro daproteína, são descritas acima). As seguintes seqüências específicas foramanalisadas pelos -inventores, e preferivelmente as seqüências do HIV aludidasna invenção são selecionadas destas seqüências ou mutações específicasdestas seqüências. Assim, as seqüências específicas homólogas às SEQ ID 1 a4 descritas acima são preferivelmente aquelas nas posições apropriadas dentrodas seguintes proteínas. Similarmente, as seqüências da presente invençãodefinidas pelas posições de resíduo dentro das proteínas de qualquer cepaviral, a saber os resíduos 51 a 80 da proteína VPR, resíduos 142 a 181 daproteína VIF, resíduos 69 a 95 da proteína REV, e resíduos 81 a 123 daproteína NEF. A lista está na forma |versão número (número gi)|identificaçãoda base de dados (por exemplo, gb para GenBank)|número de acessoNCBI|informação adicional opcional (por exemplo, o número de acesso daseqüência de nucleotídeo a partir da qual a seqüência de proteína é derivada).As seqüências e cepas virais correspondentes a partir das quais elas derivampodem ser todas encontradas a partir da base de dados de proteína NCBIpública, que pode ser acessada online nos seguintes endereços URL http://www.ncbi.nlm.nih.govientrez/query/static/help/helpdoc.html#Protein. Asbases de dados de proteína contêm dados de seqüência das regiõescodificadoras traduzidas de seqüências de DNA no GenBank, EMBL e DDBJassim como seqüências de proteína submetidas ao Protein InformationResource (PIR), SWISS-PROT, Protein Research Foundation (PRF), eProtein Data Bank (PDB) (seqüências de estruturas resolvidas).Proteínas VPR

|1469310|gb]AAB05046.1|, |77167539|gb|ABA62729.1j, [77168205|gb[ABA63062.1|,j3218I54jemblCAB05081.il, |321S152|emb[CAB05080.I|J |22596296|gb[AAM)3081.1JAF45,|32351 l05|gbfAAP765Í3.1 Jj |25166S39|gb|AAN73627.1IAF48, |7716829SIgb|ABA63108.1|

17716771 l|gb|ÁBA62815.1jr |77167347|gb[ABA62633.1|[77167745|gb] AB A62832.1j, 177167607jgblABA62763.il,[77167961Jgb|ABA62940* l j* |77l67707|gbjABA62813,1|77167317fgb!ABA6261S.lÍ, !77i67535[gb|ABA62727.1j5J6910971jgb]AAF31322. IfAF 146, |77167947|gb|ABA02933Λ!,

|77167789fgb]AB A62854.1|,|77167449f^|ABA62684.lj}|77167457|gbfABA62688.1 j,|49472934jgb|AAT66278.l|,i77167787lgbJABA62853.ll,177167611 |gb|ABA62765.1|, |7l7260l5|gb|AÁZ39Í46J[I [82283746|sp[Q66MS0]Q66MS0 9,

[771 6S227]gb JABA63073.1[77167381 |gb|ABÁ62650,1j,|57545338Igb|AAW51572Λ\,|46254407|gb[AAS86166.1 j,|77168366[gb|AB A63142.1

j57545534lgblAAW51570.il,[221480[dbj[BAAÔ0995.1j,|77168272jgb| AB A63095.11,[2570312|gb[ AAC97573.118,|5001943|gb|ÂAD37222,11

|77167367[gb|ABA62643. Ij|77167689|gb|ABA62804.1 f,|77167513|gb|ABA62716.1|,|77167533jgb|ÀBA62726,lj5|5001933|gb|AAD37217.1js

|5001923|gbtAAD372!2.1]500l913|gb[AAD37207.1|, [82307194|spjQ9W9L8jQ9W9L8_9

|5001953fgb[AAD37227.1), [74273444]gb]ABA0l428,I|,

|74273424lgbjABA01410J |t [55735953|gb|AAV59686.1J5|77I67979|gb|ABA62949.1|77167519|gbjABA62719.1 [,

|77168089|gb|AB A63004.11, [77167S47|gb|ABA62S83.1

|77167795jgbÍABA62857.1|, jl6118321|gb|AALl2694,lj,|822846S$jsp|Q6EFW3 jQ6BFW3_9s

j37677897|gb]AAQ97563.11, [37682582|gb|AAQ98264,1 [,

[77167345jgb|ABA62632,1Js |7716784I|gb[ÀBA62880.1j,

|7í725995|gb[AAZ3912g4|í l57545372lgblAAW5l5B9.ll»)77168264|gb[ABA6309Llj77!67867|gbfABÂ<S2893il|í

|3193275|gb|AAD03328.1 |77167499]gb]AB A62709.1 f,

|74273434|gb|ABÂ01419.1 f,[77168009|gb|ABA62964.1 ],177167451 [#|ABA62685.1[77168197|gb[ABA63058.11„183026816!gb|ABB96451.1|,|37677907|gb]ÁÁQ975?2.1j,177167595|gblABA62757.1 [,Í55735961[gbjAÁV59693.1],|57545370lgb|AAW51588.1j,[77167967|gb |AB A62943*1fS738569[émb|CAB53045.1|,146254431 |gb|AAS86184.11,|77167553|gb|AB A62736.11,|77 i 68262|gb|AB A63090.1j,}77l67385|gb|ABA62652.1|,|77167567|gb|ABA62743.11,|77168378|gb|ABA63148.1|,177167721 |gb|ABA62820.1},|1688186|gb[AAJB51055.1|,115407034|gbj AAG32141,11.J31559655|dbj|BAC77480.1j,|77168260|gb|ABA63089.1177167431jgb|ABA62675.1 j,|2570305|gb|AAC63086.1|,|77167443|gb|AB A62681.11,l77167517jgblABA62718.il,l77168019lgbJABA62969.il,|77168007|gb|ABA62963.1 j,|77167447|gb (ABA62683.1j,J77167637|gbjABA62778.11,|77168031 |gbjABA62975.1j,J77167727|gb|ABA62823.1 j,|5001969|gbJAAD37235.1|,

|77l67929|gb|ABA62924.1|,l77167547lgblABA62733.ll,|77167509|gb|ABA62714.1|,|77168015|gb|AB A62967.1|2393853|gb| AAB70154.1J,|77168294|gb|ABA63106,1j,l77167565lgblABA62742.il,|1688182|gb|AAB51053.1),|l5407038fgb|AAG32143.1|,|77167455|gbjABA62687.11,177167773 |gb|ABA62846.11,|77168057|gb(ABA62988.1|,|77168127|gbjABA63023.1J,|77167463|gb|AB A62691.lj,|77l67705|gbjABA62812.1|,J77168406jgb| ABA63162.1 j,|77168073|gblABA62996.11,177168169|gb|ABA63044.11,|77167515|gb|ABA62717.1|,177168085|gb|AB A63002.11,|2944130|gb|AAC05237.1|,

177167319|gb|AB A62619.11,|77168101|gj5|ABA63010.1|,|77168336[gb|ABA63127.1|,|77167899|gb|ABA62909.1|,|71726025jgb[AAZ39155.11,|77168035|gb(ABA62977.1|,|31559665|dbj|BAC77489.1|15407036|gb|AAG32142.11,|77168394|gbjABA63156.1 j,|77168217jgb|ABA63068.11,|77168059|gbJABA62989.1(77167427jgbj AB A62673.11,|77168087|^|AB A63003.11,(77168380]gb|ABA63149.1|55735988|gb|AAV59717.1j,J77168203|gblABA63061.1 f,|77167603|gb|ABA62761.1|5|77168005jgb|ABA62962.1|,|77168l43lgb|ABA6303l.l|,|77167785|gb[ABA62852.1|,|3002833jgb|AAD03193.1|,1185514|gbjAAA87861.1|,

(57869572)gb|AÀW57622.1|,11185512{gb|AAA87860.11, |62956369|gb|AAY23504.1J, |25166899|gb|AAN73681.1JAF48,

118074002|emb|CAC86567.11, 138570392|gblAAR24634.119 |57545362|gbJAAW51584.1),

|3218473]embiCAB05069.1|, |57545320[gb|AAW51563.1|, |77167325|gb|ABA62622.11,J6651484|gb|AAF22332.1 |AFl 93, |6651476|gb|AAF22324.1|AF193,

118699224|gb|AAL78471.11AF41, |83026808|gb|ABB96444.11,118699231 |gb|AAL78477,1 |AF41} |186992511gb|AAL78492.1|AF41,

|29119299|gb|AA063217.1|, (829465 |gb|AAA79594.1|, }829458|gb|AAA79588.1|,

|77168402|gb|ABA63160.1J, |77167963|gb|ABA62941.1J, |77168179|gb|ABA63049.1|,

(77168117|gb |AB A63018.1|77167635jgbfABA62777.1 j,J77168039Jgb| AB A62979.1j,l77167699]gb(ABA62809,1|,l328434Jgb|AAB04039.1|,|7416688Jdbj (BAA93984,11,|57545276|gb|AAW51541.1112964731 |gb| AÀK.11294.1J,|77167767|gbJABA62843.11,|77168284|gb|ABA63101.11,J77167331 jgb(ABA62625.1(,|77167949|gb|AB A62934.11,|77167679|gb{ABA62799.1|, |25167049|gb|AAN73816.1|AF48, |77l68316(gb|ABA63117.1 j,

|77167391jgb(ABA62655.11, |37683040|gb|AAQ98596. lj, (38491794|gb|AAR22172.1 [,

|77167737|gb|ABA62828.1|, |77168340|gblABA63l29.1|, |77l68223|gb|ABA63071.1(,

l77168207jgblABA63063.il, j77167831|gb|ABA62875.1|, j77167585|gbjABA62752.1|,

|38570402|gb|AAR24639.11, |31559693|dbj|BAC77514.1 |t (77168268|gb) ABA63093.11,

|78172844)gb|ABB29376.1|77167693|gb|ABA62806.11, |77168065jgb| AB A62992.1|,

177167551 igbjABA62735.lj,|77167919|gb|ABA629l9.1|,177167371 jgbJAB A62645.1|,|77167369|gb| AB A62644.11,112964719|gb| AAKl 1288.1|,|7416686(dbj|BAA93983.1|,(77167675|gb | AB A62797.11,112964725|gb | AAK11291.1 j,112964729|gb| AAKl 1293.1],112964717|gb|AAKl 1287.11,|77167765|gblABA62842.11,|77168362|gb j AB A63140.1 j

l77168213lgbjABA63066.ll,|77167793|gb|ABA62856.1 (,|77167557|gb|AB A62738.11,112964721 IgbjAAKl 1289.11,|77167623JgbjAB A62771.11,|77168326|gb|AB A63122.1 j,|12964727|gb|AAK11292.11,112964733|gb|AAKl 1295.1 j,J12964723|gb(AAKl 1290. lf,|77167813jgb|ABA62866.1|,|12964715|gb|AAK11286.1|,|3694864|gbf AAC62478.1 j,(77167529|gb| ΑΒΑ62724.11,[77167473|gb|ABA62696.11,(77168165|gb|ABA63042.1j,|77167615Jgbj AB Α62767.11,|77167429|gb|ABA62674.11,(77l68193jgbjABA63056.lj,(77167857|gb|ABA62888.11,f77168258|gb|ABA63088.1|,l77i67815jgblABA62867.ll,|77168306|gb|ABA63112.1|,|77168338|gb|ABA63128.1|,|77168003|gb|ABA62961.1 j,|77168239|gb|ABA63079.lj,177167621 IgblAB A62770.lj,|2281656|gb|AAB64166.1|,

|77167797|gb|ABA62858.1J,|77167337|gb|ABA62628.1|,|77167491|gb j AB A62705.11,l77167511lgbjABA62715.il,|77168370|gb|ABA63144.1|sj?7168360|gbjAB A63139.1 j,|77168390|gb|ABA63154.1 j,|77167941Jgb |ABA62930.1 j,|77168091Igb|AB A63005.11,|77167407|gb|AB A62663.1 j,|77168163jgb(AB A63041.1j,|77167641 jgb|ÁBA62780.1|,j77167893[gb jAB A62906.1 j,|77168119|gbjAB A63019.1|77168095|gb|ABA63007.1(,

|77168318|gb|ABA63U8.1|, |25166799|gb|AAN73591.1|AF48>

|77167587|gb|ABA62753.11,|37677787|gb| AAQ97464.il,|39777407|gb|AAR30986.11,|77168107jgb|ABA63013.lj,155925122|gb|AAV67928.11,]77168392|gb|ABA63155.1|,|77167409|gb|AB A62664.ll,177167811 |gb|ABÁ62865.1(,11185550|gb|AAA87879.1|,j 11761306|dbj |B AB19242.1177167915jgb|ABA62917.11,j57545344jgb|AAW51575. Ij5Í77168053jgbjABA62986.1|,|37725240|gb|AAR02303.1|,j37725190jgb|AAR.02258.1|,|77168396|gb|ABA63157.1|,177167423jgb|ABA6267Llj,jl 160019lembjCAA92863.liÍ77167907|gb|ABA62913.1|,

151572116|gb|AAU06764.1|,|77168155|gb| AB A63037,11,|77167981 |gb| ABA62950.11,|66864684]gb|AAY57412.11,|55925H4|gb|AAV67921.1|,177167823 |gbjABA62871.1|5l77167343lgbjABA62631.il,|77167665|gbÍABA62792.1|,|32399660|émb|CAD58637.11,[77168093 |gb|ABA63006,l|,|83026778|gb|ABB96417.11,|77168330|gb|ABA63124.1j,(77167731 |gb| ABA62825.1 j,j37725220|gb|AAR02285.1|}j37725230jgb j AAR02294.11,177167817lgbjABA62868.ll,|77167939jgbjABA62929.11,(77167591 |gblABA62755.11,|3218477|emb|CAB05071.11,

|139395|sp|P05954|VPR_HVlRH, (32857 l|gb(AAA45055.1|,j1160021 |emb|CAA92864.1 (, |1477880|gb| AAB05523.11,|55735979|gb|AAV59709.1|, 125166859|gb|AAN73645.1 |AF48,|77168001 |gbjABA62960.1[, |37677867|gb|AAQ97536.1|,jl39394|sp|P20891|VPR_HV10Y, |328446|gbJAAA83394.l|,

[77168081 |gb|ABA63000.11,Í74273358jgbjABA01353.1j,jl 160039|embjCAA92873. lj,Í57545282|gb|AAW51544.1|77168037|gb jAB A62978.1|5805265|gb | AAD51914.1j7416664ldbjlBAA93972.ll,j7416670|dbj|B AA93975,1|,

|74273383|gb|ABA0l374.11,|74273349|gb|AB A01345.1[,jl 160091 |emb|CAA92899.1J,|1465784|gb|AAB05601.11,|57545330|gb|AAW51568.1|,j57545354|gb|ÀAW51580.1|,|7416674|dbj|BAA93977.1|,|7416672|dbJ|BAA93976.1|,

|77167687|gb|ABA62803.1|,(77168308|gb(ABA63113.1|,|77167477|gb|AB A62698.11,|77167441|gb|AB A62680.1 j,j77l68159jgbjABA63039.il,|77167985jgb|ABA62952.1 j,Í77168278|gb]ABA63098.1|,|77167593|gb|ABA62756.1 j,177167671 |gb|ABA62795.11,[77167329[gb|AB A62624.1J,177167739jgb|AB A62829.11,|77167917jgbj AB A62918.1j,j77167839|gbjABA62879.1|,j77167895jgbjABA62907.il,|24753975|gb|AAN64098.1|,|77168233)gb|ABA63076.11,|37677797|gb|AAQ97473.1|,|77167995|gb|ABA62957. Ij,131559617|dbj |B AC77446.1 j,|55925130|gb| AAV67935.11,|55925138jgbjAAV67942.ll,(77168312|gb] ABA63115.1 j,Í77167669jgbjABA62794.1|,|77167657jgb|ABA62788,1|,lll761313ldbjlBAB19248.il,|77167485|gb]ABA62702.1 j,|77167525|gbj ABA62722.11,|77167755jgbj AB A62837.1 j,|37725250jgbjAAR02312.1],(37725200lgblAAR02267.il,(37725210jgb|AAR02276.1 j,(77167881 |gbjABA62900.1 j,(77167411 |gbjABA62665.11,|77167425|gb(AB A62672.11,(16118294|gb|AAL12670.1 j,|3114559|gb|AAD03l78.1j,|1477796|gb|AAB05481.11,(38570394jgbjAAR24635.ljsl37677857tgblAAQ97527.ll,|1160107|emb|CAA92907.I|,[74273375|gb(AB AOl 367.1|57545296|gbjAAW51551.1),(57545312|gb|AAW51559.1),(77168372|^| AB A63145.11,lll51163lgblAAA85233.ll,|1160035|emb(CAA92871.11,|7416666|dbj|BAA93973.1 j,|7416668jdbj [BAA93974.1 j,|7416708|dbj|BAA93994.1|,|2286128|gb|AAB64275.1|,[4205066jgb|AADl0938.11,|4205039|gb|AADl 0914.1 j,{4205012jgb|AAD 10890.11,|38570406|gb|AAR24641.1|,|326422|gb|AAB59749. l|,

|27446736|gbjAAL62481.1|,|82279710jsp|042084|042084_9,l4205057lgbfAAD10930.ll,J4205030|gb|AAD10906.1|,|4205003|gb|AAD10882,1 j,

f22S6137jgbJAAB64283.11,|4205075|gb|AAD10946.11,|4205048|gb|ÁAD10922.11,|4205021 |gb|AADl 0898.1|,J4204994jgbj AADl0874.1 j,

!38570388jgbtAAR24632.il, |139386|sp|P05928|VPR_HVlBR,

j55117 ljgb|AAA21763.1),|328421 jgb|AAA44990.1j,l8218029lembICAB92789.il,|55740259|gb|AAV63830.lj,|329383|gb|AAA45368.1|,|2570294|gb|AAC32650.1|,|38570408|gb|AAR24642.11,

(288728 i7|ref]NP_057852.2|>j902802|gb|ÁAB60574.lj, |1351413|sp|P12520|VPR_HVlN5,|14269050|gb|AAK58007.1JAF36, [77168111 |gb|ABA63015.1|,|77167761 |gb|ABA62840.11, |77167403|gb|ABA62661.1|,|55740249|gb|AAV6382l.l|, |139384|sp|P12519[VPR_HVlZ2|61102539|gb|AAX37685.1|, |61102531|gb|AAX37678.1|,

|77167825}gb|ABA62872.1|, |77168105|gb|ABA63012.1|, ,_____________________,

|77167507|gb|ABA62713.11, |37682493|gb|AAQ98184.1|, |55740239|gb|AAV63812.11,|55740229jgb|AAV63803.11, |328160|gbJAAA44871.11, |25166719|gb|AAN73519.1 |AF48,[38491814|gb|AAR22190.1|24181481|gb|AAN47103.1|, |139392|sp|P05955|VPR_HVlMA,|77168025[gb|ABA62972.11, |37677887|gb|AAQ97554.11, |37677877Jgb|AAQ97545.11,|139389|g>|P05956|VPR_HVlEL, |326681|gb|AAA44327.11, |5790l 101|gb|AAW57866.11,|32399669|emb|CAD5 8646.11, [38491804|gb|AAR22181. 1||3002880jgb|AAD03235.1|, |77168061 |gb[AB A62990.11,

|16118274|gb|AAL12652.1|,|57545326|gb|AAW51566.1|,|23394922jgb|AAN31644.11,|83026788[gb[ABB96426.1I,|829435 |gb|AAA79568.11,[8294l9|gbjAAA79554.1j,|57545304|gb|AAW51555.11,J7416660JdbjlBAA93970.il,|1185518|gb|AAA87863.11, |82295315 |sp|Q89493|Q89493_9,|1185546|gb|AAA87877.1|, |82295327Ísp|Q89588|Q89588_9,|1185538|gb|AAA87873.1|, |1477860Jgb|AAB05513.1|,11185522|gb[AAA87865.11, |1185544|gb|AAA87876.1|,|1477846|gb|AAB05506.1|, |1477858|gb|AAB055l2.1|,82305555|sp|Q9PWZ2|Q9PWZ2_9, 11185540|gb|AAA87874.1 j,

]77167879Jgb|ABA62899.1J37677847jgb|AAQ97518.1),177168071 IgbJAB A62995.1J,|45360202|gb|AAS59234.1|,|829450|gbJAAA79581.1),J829427|gb|AAA7956l.l|,|77167571 |gb|ABA62745.11,|37677757|gb|AAQ97437.1J,]47060058|gb|AAT09644.11,|1477852|gb|AAB05509.I|,|1477854fgbJAAB05510.1|,|1185526|gb|AAA87867.1|.|1477848|gb|AAB05507.11,|1477856|gb|AAB05511.1|,|1185528|gb|AAA87868.1|,|57545360|gb|AAW51583.1|,|3218164|emb|CAB05086.1|,|77168248|gb|ABA63083.1|,|77167933 |gbjABA62926.11,jl 160083|emb|CAA92895.1|,|11177372|gb|AAG32248.11,jl 1177424|gb|AAG32274.1 j,(11177414Jgb|AAG32269.1 j,[11177404|gb|AAG32264.11,|U 177388|gb)AAG32256.1|,111177382|gb|AAG32253.11,|11177376]gb|AAG32250.11,|11177368|gb|AAG32246.1|,

|77168368|gb|ABA63143.1|,[77168133|^>|AB A63026.11,|37681544|gb|AAQ97653.1|,|57545322|^)|AAW51564.1 j,|62956358|gb|AAY23494.11,|77167749|gb| ABA62834.1J,|829443jgb|AAA79575.11,(82941 l|gb|AAA79547.1|,|37677767|gb|AAQ97446.11,jl 6118325|gb| AALI2697.1),

|I477850|gbjAAB05508.1|,J57545358Jgb|AAW51582.1|,|3218170Jemb)CAB05089.11,|77167771 |gb| AB A62845.1j,|77168320|gb| AB A63119.11,|57545294|gb|AAW51550.1|,[11177390jgb|AAG32257.1),[11177420)gb|AAG32272.1|,|11177412|gb|AAG32268.1|,|11177400|gb|AAG32262,11,|lll77386|gb|AAG32255.1|,|11177380|gbJAAG32252.1j,Jl 1177374jgb|AAG32249.11,111177365jgb|AAG32245.1|,

|1185530|gb|AAA87869.1|,13218166jemb|CAB05087.1J,|1160103|emb|CAA92905.1 j,|77167633|gb|ABA62776.11,|3218168|emb|CAB05088,l|,llll77392lgblAAG32258.il,|11177426|gb|AAG32275.1|,|11177416|gb|AAG32270.11,Jl 1177410|gbJAAG32267.11,111177396|gb| AAG32260.1J,jl 1177384|gb|AAG32254.1|,Jlll 77378|gb| AAG32251.1111177370Jgb| AAG32247.1J,|11177363|gb|AAG32244.1|,|11177361|gb|AAG32243.1|, |11177359]gb]AAG32242.1|,]11177394jgb|AAG32259.1|, ]lll77422!gb|AAG32273.1|,111177398jgb] AAG32261.1], |11177418|gb|AAG32271.1|,|1160069]emb|CAA92888.1|. |1477810|gb]AAB05488.1|,|77l67733]gb|ABA62826.Í|, |82286715]sp|Q6SZTl|Q6SZTl

|38570378]gb|AAR24627.1|,|3327763]gb]AAC41171.1],|3327757|gb|AAC41168.11,|3327749jgb|AÃC41164.1|,]3327747]gb]AAC41163.11,|3327761jgb]AAC41l70.1|,]3327767|gb|AAC4ll73.lj,

|11177406]gb|AAG32265.11,|11177402|gb|AAG32263.1|11177408|gb|AAG32266,l |,|57901072|gb|AAW57840.11,, |38570404|gb|AAR24640.1 j,|77167697|gb|ABA62808.11,|3327765|gb|AAC41172.11,|3327769|gb|AAC41174.1],]3327734|gb|AAC41157.11,l3327738lgblAAC41159.il,|3327745|gb|AAC41162.1 j,|3327753|gb|AAC41l66,l |,

]54124762]gb]AAV30102.1|,|3327755|gb[AAC41167.1|,13327771 |gb|AAC41175.1],|3327743|gb|AAC41161.11,|3327736|gb|AAC41158.1|,|3327759|gb|AAC41169.1|,

_________„____________________„ |3327740|gb|AAC41160.11,

|22596557|gb|AAN03313.1 |AF45, |1160095|emb|CAA92901.1], |77167559|gb|ABA62739.1j,|332775 l|gb(AAC41165.1|, ]3218186|emb]CAB05097.1|, l3218172lemblCAB05090.il,j 116010ljemb|CAA92904.1], |1160077|emb[CAA92892.1], |1160063|emb]CAA92885.1|,|23392783|emb|CAD26729.1|23392781 |emb|CAD26728.11, Í23392779|emb]CAD26727.11,|1160097lemblCAA92902.ll, |1160l05|emblCAA92906.11, |3218148{emb|CAB05078.Illl60081lemblCAA92894.ll, 11160085|emb|CAA92896.11, |57545284|gb|AAW51545.11,|1160093|emb|CAA92900.1], |1160073|emb]CAA92890.l|, |57545310|gb|AAW51558.11,|77167461|gb| ABA62690.11, |22596303|gb|AAN03087.1|AF45, |3218150|emb|CAB05079.1|,

|77167561|gb|ABA62740.1|, 11160067|emb|CAA92887.1|1160061 |emb|CAA92884.11, |1160079|emb]CAA92893.11,|82283750|spjQ66MS8|Q66MS8_9,

|36365493jgb|AAQ86702.1l36365457jgbjAAQ86670.il,|36365412|gb|AAQ86630.1j,|36365376]gb]AAQ86598.1|,|363655471gb|AAQ86750.l|,|36365511 lgb|AAQ86718.1],

]3327730]gb| AAC41155.11,]33276S0|gb]AAC41130.1],|3327726|gblAAC41153.1),|3327702|gb|AAC4H41.lj,|3327696|gb]AAC41138.1 j,|3327686|gb]AAC41133.1],|3327712|gb|AAC41146.1|,|3327710|gb|AAC41145.1J,|3327704|gb|AAC41142.1|,|3327724|gb|AAC41152.1|,|77167969]gb|ÀB A62944.11,]3218481|emb|CAB05073.1],

lll60059lemblCAA92883.ll,|36365466]gb|AAQ86678.1|,|36365538|gb|AAQ86742.1|,[36365403|gb|AAQ86622.1 j,|3636542 l|gb|AAQ86638.1|,|36365385|gb|AAQ86606.1|,]36365430|gb]AAQ86646.11,|36365502|gb|AAQ86710.1|,]36365520|gb|AAQ86726.1],|23392753|emb|C AD26714.11,

|36365484|gb|AAQ86694.1 ],|36365448|gb |A AQ86662.11,|36365394|gb|AAQ86614.11,]36365439|gb]AAQ86654.11,|36365529|gb|AAQ86734.11,|36365475|gb|AAQ86686.1 j,|82295424|sp|Q8AC16|Q8AC16 9, . .

]23392751[emblCAD26713.1|, j23392749|emb|CAD26712.1157545350|gb|AAW51578.1|,|57545318|gb|AAW51562. í[, |57545292|gb|AAW51549.1|, |47118233|gb|AMÜ231.l|,

|3327728|gbjAAC41154-1],|3327732|gb|AAC41156.1|,|3327722|gb|AAC41151.1|,|3327700|gbIAAC41140,l|í|3327694|gb|AAC41137.1 j,|3327684lgbjAAC41132.1],l3327690lgblAAC41135.il,|3327706|gb| AAC41143.1],|3327718|gb]AAC41149.11,38570400|gb(AAR24638.1|,|3218162|emb]CAB05085.11,|77168123]gb|ABA63021.1|,Í23392777|emb|CAD26726.í|, |23392775]emb]CAD26725.1 ], ]23392773|embjCAD26724.1|,]7716813I]gb|ABA63025.1|. ]57545342|gb]AAW51574.1|, |57545272lgb|AAW51539.1|,|77168342|gb| ABA63130.11, |27446734|gb|AAL62480.1|, |24753986]gb|AAN64107.11,|12964709|gblAÀKl 1283,1], |77168215|gb]ABA63067.1|, ]77167989|gb]ABA62954.1|,

]3327682]gb|AAC41131.1],]3327714|gb|AAC41147.1],|3327716|gb]AAC41148.lj,]3327698|gb]AAC41139.1],|3327692|gb|AAC41136.1],|3327678|gbjAAC41129.1|,|3327720]gb]AAC41150.1],|3327688]gb|AAC41134.11,]3327708]gb|AAC41144.1],|77168075|gb|ABA62997.1 j,l3218160|emb|CAB05084.1|,|77168067|gb]ABA62993.11,ll0436172lgbjAAG16846.il,|3163933 |emb|CAA06949.1|,jl0436153lgbiAAG16830.il,|1160089jemb|CAA92898.1j,}3218182|emb|CAB05095,ljn23016|gb|AAC54645.1|,l3098586|gb|AAC68853.1|,

110436105|gb|AAG16787.11,ll0436162fgblAAG16838.il,110436124|gb|AAGl 6804.11,|77168079|gb|ABA62999.11,|49472952|gb|AAT66294.1 j,|1123006|gb |AAC54636.1|,

|77168021 |gb|AB A62970.11,|77167987|gb|ABA62953.1|,|55275259|gb|AAV49471.1 j,|59710501|gb|AAWS8730.1|,

|10436115|gb[AAG16796.1|,|10436l43|gb|AAG16821.1|,J10436134|gb|AAGl 6813.11,|77167465|gb|ABA62692.1J,|3218180|emb|CAB05094.11,|255649|gb|AAB23297.11,

|549427|sp|P35967jVPR_HVlY2,|139385|sp]P05952|VPR_HVlA2, |328664|gb|AAB59878.1|, |3098576|gb|AAC68844.1|,

|23392771 |emb|CAD26723.11, |23392769|emb|CAD26722.1|, |23392767|emb|CAD26721.1|,

|78172816|gb|ABB29351.1|, |77l68302|gb|ABÀ63110.1|, |77167723|gb|ABA62821.1|,l77l67645lgblABA62782.il, |77167521|gb|ABA62720.1|,|77167983|gb|AB A62951.11, |77167437|gb|AB A62678.1|27446730|gb|AAL62478.1J, |77168237|gb|ABA63078.11,|59710499|gb|AAW88729.1|, I59710503|gb|AAW88731.1|,

|59710494|gb|AAW88727.11, J597X 0490|gb|AAW88725.1|, |5527512%b| AAV49354.1 j,

|55275119|gb|AAV49345.1 j, |59710492|gb|AAWS8726.11, |59710488|gb|AAW88724.1|,

|59710496|gb|AAW88728.1|55275139|gb|AAV49363.1|, |55275249|gb|AAV49462.1|,

|55275239|gb|AAV49453.11, |55275189|gb|AAV49408.1|, |55275199|gb|AAV49417.1|,

|59710560|gb j AAW88757.1j, |597105641gb|AAW88759.1J, |59710558[gb|AAW88756.l|,

|59710556jgb|AAW88755.11, |59710566|gb|AAW88760.11, |59710562|gb|AAW8875S. 11,

[55275219{gb| AAV49435.11, |59710548fgb|AAW88752.11, |59710546|gb|AAW88751.11,

|59710538|gb| AAW88748.11, |55275229|gb| AAV49444.1j, |59710554|gb|AAW88754.11,

|59710552|gb|AAW88753.11, J59710542|gb)AAWS8749,1|, |55275209|gb|AAV49426.11,

159710544|gb|AAW88750.1|, |59710518|gb|AAW88738.1|, |597105l6|gb|AAW88737.1|,

|55275179|gb|AAV49399.11, |59710505|gb|AAW88732.1|,

|59710507jgb|AAW88733.1|, |59710528|gb|AAW88743.1|,

|59710509|gb|AAW88734.1J, |59710522|gb|AAW88740.11,

j59710526|gb|AAW88742.11, |59710524|gb|AAW88741.1|,

|59710536|gb|AAW88747.11, |59710532]gb|ÀAW88745.11}159710534|gb|AAW88746.11,

|59710520|gb|AAW88739.1 j,155275159|gb| AAV49381.1|55275149|gb|AAV49372.1|,|59710513 |gb [AAW88736.11,155275169igb|AAV49390.11,|59710530]gb|AAW88744.1|.|62548201 |gb|AAX86752.1|,|77167709|gb|ABA62814.11,|77168274|gb|ABA63096.11,|77167729|gb|ABA62824,11,|30027257|gb|AAP06260.11,17416682|dbj |B AA93981.11,|77167865|gb| AB A62892.11,177167493 |gb|ABA62706.11,|Í7046525|gb|AAL34565.11,|2570332|gb|AAC32659.1|,|52421750|gb|AAU45386.1j,|62467702|gb|AAX83957.11,]17902118|gb|AAL47787.1|,117902096jgb] AAL47769.1|,|31980429|dbj|BAC77749.11,|74315752|gb|ABA02477.1|,|74315735|gb|AB A02462.1j,

[25166949|gb|AAN73726.1 |AF48,

[62548181 |gb|AAX86734.11,162548171 |gb|AAX86725.11,|77167799|gb|ABA62859.11,|7416646|dbj |B AA93963.11,|7416678|dbj|B AA93979.11,|7416680|dbj|BAA93980.1|,|1185542|gb|AAA87875.1j,|3327542|gb|AAC41064.1|,117902151 |gb| AAL47814.11,[38491483|gb(AAR21895.1|,|57545374]gb|AAW51590.1),|17902129|gb|AAL47796.11,j17864034|gb|AAL47029.11,|3403229|gb|AAC29062.1J,|4262340|gb| AAD14576.1 j,!60218867|gb|AAX14845.11,117864044|gb|AAL47038.11,

|57545352|gb|AAW51579.11,|62548191 |gb|AAX86743.11,[62548161 |gb|AAX86716.1|,|77167803|gb|ABA62861.1|,|7416648|dbj|BAA93964.11,|7416676|dbj|BAA93978.11,|1160087|emb|CAA92897.1|,I l477844|gb|AAB05505.11,|3327524|gb|AAC41056.1 j,117864054|gb|AAL47047.11,|62361772|gb|AAX81420.1),|74315742|gb|ABA02468.1|,117902107|gb| AAL47778.11,j17902140|gb|AAL47805.1j,|31980439|dbj |BAC77758.1|,|7321147|emb|CAB82229.1|f|74315782|gb|ABA02504.11,|62467712|gb|AAX83966.1|,

122596351 |gb|AAN03130.1 |AF45,115281443|gb|AAK94231.1 |AF36, |39777387|gb|AAR30968.11, |39777377|gb|AAR30959.1|82284358|sp|Q69GS5|Q69GS5_9, |61102671|gb|AAX37799.1|, |3808282|gb|AAC69308.1|22596547|gb|AAN03304.1|AF45, |25166869|gb|AAN73654.1|AF48

|39777437|gb|AAR31013.1|, |33331478|gb|AAQ10922.1|, |33331458|gb|AAQ10904.1|33331468|gb|AAQ10913.1|, |61102686|gb|AAX37812.1|, |37682444|gb|AAQ98140.1|25166647|gb|AAN73455.1 |AF48, |22596517|gb[AAN03277.1 |AF45

|22596537|gb|AAN03295.1|AF45, |29409329|gb|AAM67405.1

\11794578|emb|CAI28820.1|, |29409317|gb|AAM673 95.1|, |29409298|gb|AAM67378.1|71794607|emb|CAI28847.1 j, |71794598|emb|CAI28838.1|, |29409310|gb|AAM67389.1

|71794588|emb|CAI28829.1|,|22596507Ígb|AAN03268.11AF45,|22596235jgb|AAN03027.1|AF45,l62467719lgblAAX83972.ll,|5059053|gb|AAD38892.1 |AF119,|5059044|gb|AAD38884.1 |AF119,|6690777|gb|AAF24336.1|AF197,|25166739|gb|AAN73537.1|AF48,

|37683030|gb|AAQ98587.1|,|77167783|gb|ABA62851.11,

|77167541|gb|ABA62730.1|,|2801507|gb|AAC82595.11,|62291051 |sp|P69728 |VPR_HV11,|62291049|sp |P69726|VPR_HV 1H,

|771673 ll|gb|ABA62615.1|,

|25166889|gb|AAN73672.1 |AF48|14530266|gb|AAK65996.1 |AF31|5668926|gb|AAD46078.1 |AF076|5733956|gb|AAD49793.1 |AF107|3947929|gblAAC82619.1|1732488|gb|AAB38835.1|37683020|gb|AAQ98578.1|49472943 |gb|AAT66286.1|1185516|gb|AAA87862.1|62291052|sp|P69729|VPR_HVlP|62291050|sp|P69727|VPR_HVlH|62291048|sp |P697251VPR_HV 1B

|328557|gb|AAB59869.1|, |326390|gb|AAA44203.1|,

jl39383|sp|P05927|VPR_HVlB5, ]327463|gb|AAA44655.1|,

|37677817|gb|AAQ97491.1|,

|5001959|gb|AAD37230.1|,

|5001929]gb]AAD37215.1|,

|77167653|gb| AB A62786.11,

|77167757|gb|ABA62838.1|,

|57901082|gb|AAW57849.1|,

|74273414|gb|ABA01401.1|,

|77167851|gb|ABA62885.1|,

|4324907|gb| AADl 7171.11,

|37677807|gb|AAQ97482.1|,|5001949|gb|AAD37225.1|,|5001919|gb)AAD37210.1|,|5971051 l|gb|AAW88735.1|,|3378125|gb|AAC28448.1|,|77168137|gb|ABA63028.11,|74273394|gb|ABA01383.1|,|77167751|gb|ABA62835.1|,

|328455 |gb|AAA44998.11|32261273|gb|AAP74173.1||32261269|gb|AAP74170.1|5001939|gb|AAD37220.1|77167845|gb|ABA62882.11|77167355|gb|ABA62637.lj|77167605|gb|ABA62762.1||57869582|gb|AAW57631.1||74273404|gb|ABA01392.11|4324913|gb|AAD 17177.11117046685|gb|AAL34709.11

|4324919|gb|AAD17183.1|,|22596412|gb|AAN03184.1 |AF45, |25166909|gb|AAN73690.1|AF48

\25166999|gb|AAN73771.1 |AF48, |38491939|gb|AAR22302.11, |11177449|gb|AAG32286.11111177445|gb|AAG32284.11, Jlll77440|gb|AAG32282.11,j 11177436|gb|AAG32280.11, j 11177434|gb|AAG32279.1 j,|11177430|gb|AAG32277.11, [11177443|gb|AAG32283.1|,Jl 1177428|gb|AAG32276.11, |11177451 |gb|AAG32287.11,|22596225|gb|AAN03018.1|AF45, |77167597|gb|ABA62758.1|,

|2393855|gb|AAB70155.1|,|40021876|gb|AAR37189.11,[40021836|gb| AAR37161.11,|40021796|gb|AAR37133.1|,l40021736lgblAAR37091.il,|40021846|gb|AAR37168.11,|40021756|gb|AAR37105.1|,|26518640|gb|AAN83914.11,|77167659|gb|AB A62789.11,

|40021886|gb|AAR37196.11,|40021866|gb|AAR37182.1|,|40021826|gb|AAR37154.1|,|40021776Ígb|AAR37119.1|,|40021726|gb|AAR37084.11,|40021746|gb|AAR37098.1|40021816|gb| AAR37147.1 j,|77168358|gb|ABA63138.1|,|77168129|gb|ABA63024.1|,

|11177438|gb|AAG32281.1||11177432|gb|AAG32278.1||11177447|gb|AAG32285.1||77168346|gb|ABA63132.1||2393861 |gb|AAB70158.11|40021716jgb j AAR37077.1 j|40021856|gb|AAR37175.1||40021806|gb|AAR37140.1||40021766|gb|AAR37112.1||40021706|gb|AAR37070.1 j|40021696|gb|AAR37063.11|40021786Ígb|AAR37126.1||77167889|gb|ABA62904.11|77167763 |gb j AB A62841.11|77167677|gb|ABA62798.1|, |4324801|gb| AADl7065.1|,|4324794|gb|AAD17058.1|, |4324776|gb|AAD17040.1|,|77168400|gb|ABA63159.1|, |77167701|gb|ABA62810.1|,|77167379|gb|AB A62649.1|, |7416654|dbj|BAA93967.1|,|25166677|gb|AAN73482.1 |AF48, |37677837|gb|AAQ97509.1|,

|7416710|dbj|BAA93995.1|,|67552989|gb|AAY68587.1|,|77168145|gb|ABA63032.1|,|77167433 |gb|AB A62676.11,|7416706|dbj |B AA93993.11,|77168270|gb|ABA63094.1|,

|7416712|dbj|BAA93996.11,|16118284|gb|AAL12661.1|,|77167927|gb|AB A62923.11,|77167759|gb|ABA62839.1|,|7416704|dbj|B AA93992.1|,|45361092|gb|AAS59317.1|,

|25166749|gb|AAN73546.1 |AF48, |16118387|gb|AAL12751.11,

|15788300|gb|AAL07747.1|,l57545332jgblAAW51569.il,|57545328|gb|AAW51567.1|,|1477838|gb|AAB05502.1|,11477832|gb|AAB05499.1 j,|1185534|gb|AAA87871.1|,|1477824|gb|AAB05495.1|,11477894|gb| AAB05530.11,|1477898|gb|AAB05532.1|,11477892|gb|AAB05529.1|,|1477866|gb|AAB05516.1|,|1477814|gb|AAB05490.1|,j 1477862|gb|AAB05514.1 j,|1477820|gb|AAB05493.1|,

177167991 |gb|ABA62955.1|,|77168352|gb|ABA63135.1|,11185536|gb|AAA87872.11,|1477834|gb|AAB05500.1|,11477822|gb|AAB05494.11,182295316|sp|Q89494|Q89494_9,11477906|gb|AAB05536.11,11477908|gb|AAB05537.1 j,j 1477902|gb|AAB05534.11,|24753956|gb|AAN64083.1|,|1477868|gb|AAB05517.1|,|1477830|gb|AAB05498.1|,|1477818|gb|AAB05492.1|,

|4324785|gb|AAD 17049.1|4324768|gb|AAD 17032.1|77167617|gb|ABA62768.1|7416652|dbj|BAA93966.1|7416714|dbj|BAA93997.1|62461846|gb|AAX83062.1|77167833|gb|ABA62876.1|71725965|gb|AAZ39101.1|77167753|gb|ABA62836.1|818218 |gb|AAB47930.1|77168374|gb|ABA63146.1|77167537|gb|ABA62728.1|57545336|gb|AAW51571.1177168115|gb|ABA63017.1|1477842|gb|AAB05504.1j 1477840|gb|AAB05503.1|1477828|gb|AAB05497.1|1477826|gb|AAB05496.111477904|gb|AAB05535.1|1477900|gb|AAB05533.1|1477896|gb|AAB05531.1|1185532|gb| AAA87870.1|1477816|gb|AAB05491.1J|1477864|gb|AAB05515.1||1477836|gb|AAB05501.1||25166959|gb|AAN73735.1|AF48|38570398|gb|AAR24637.1||77167955|gb|ABA62937.lj]61102580|gb|AAX37720.1 j|1477890|gb|AAB05528.1||1477886|gb|AAB05526.1|

|82286714|sp|Q6SZS8|Q6SZS8_9, |38570410|gb|AAR24643.1|,j 1477812|gb|AAB05489.11, |25167079|gb|AAN73843.1 |AF48,|61102652|gb|AAX37783.11, |61102644|gb| AAX37776.11,|7021461 |gb| AAF35360.11, |83026798|gb|ABB96435.11,|1477888|gb|AAB05527.1|, |2393851|gb|AAB70153.1|,|1477878|gb|AAB05522.1|, |13540185|gb|AAK29351.1|, |13569231|gb|AAK30975.1|AF28|67633319|gb|AAY78571.1|, |66473533|gb|AAY46413.1|, |67633313|gb|AAY78566.1||54124752|gb|AAV30093.1|, |77168221|gb|ABA63070.1|, |77168199|gb|ABA63059.1||37682464|gb|AAQ98158.1|, |13540175|gb|AAK29342.1|, |34330005|gb|AA065891.1||26245452|gb|AAN77382.11, |59003551|gb|AAW83558.1|, |25167069|gb|AAN73834.1|AF48117046555 |gb|AAL34592.11, |67553064|gb|AAY68654.11, 11185520|gb|AAA87864.11|57869638|gb|AAW57681.11, |77168364|gb|ABA63141.11, 117046785|gb|AAL34799.11115281463jgbjAAK94249.1 |AF36, |77168398|gb|ABA63158.1|, |38892719|gb|AAR27716.1|

|73913924|gb|AAZ91892.1|,|4324900|gb|AAD17164.1|,|4324750|gb|AAD17014.1|,|68522067|gb| AAY98661.11,|38892739|gb|AAR27734.1|,|37682413|gb|AAQ98112.1|,|73913836|gb|AAZ91813.1|,|11761292|dbj|B AB19230.1|,

112957271 |gb|AAK09117.1 |AF32,

|4324891|gb|AAD17155.1|,|67553054|gb| AAY68645.11,|4324741 |gb| AAD17005.11,|58221030|gb|AAW68205.1|,168522117|gb|AAY98706.11,|17046815|gb|AAL34826.1|,|59003670|gb|AAW83665.11,|73913866|gb|AAZ91840.1|,

|4324882|gb|AAD17146.1||4324759|gb|AAD 17023.11158220953 |gb|AAW68136.11|82571312|gb|ABB84079.1||68522077|gb|AAY98670.11|82571272|gb|ABB84043.1 j|55139323|gb|AAV41339.1||38892648|gb|AAR27653.1|

112957265|gb|AAK09112.1 |AF32,|82301933|sp|Q98VM8|Q98VM8_9,

|73913826|gb|AAZ91804.1], |59003640|gb|AAW83638.1|,|16751232|gb|AAL053 lO.lj, |17046695|gb|AAL34718.1|,|38892602|gb|AAR27612.1|, |68522156|gb|AAY98741.1|,|59003561 |gb|AAW83 567.11, |26245472|gb|AAN77400.11,|46486649|gblAAS98754.11, 115281492|gb|AAK94275.1 |AF36, |58220963|gb|AAW68145.1]|58221020jgb |AAW68196.1|, |26245462|gb|AAN77391.1|, |67553008|gb|AAY68604.1|

|16751252|gb|AAL05328.11|16751242|gb|AAL05319.lj|73913816|gb|AAZ91795.1j117046725|gb|AAL34745.1 j|17046535|gb|AAL34574.1

|55139352|gb|AAV41365.1],|77167647|gb|ABA62783.11,|82571409|gb|ABB84166.1|,|24181511|gb|AAN47130.1|,|63098403|gb|AAY32444.1|,|68521977|gb|AAY98580.1|,|4324849|gb|AADl 7113.11,|4324810|gb|AAD17074.11,

j 17046645 |gb|AAL34673.11|57869611 |gb|AAW57657.1J|26000267|gb|AAN75301.11|24181501|gb|AAN47121.1|117046575 |gb|AAL34610.11|37682424|gb|AAQ98122.11|58221002|gb|AAW68180.1|]11761299|dbj|BAB19236.1|

|58220973 |gb|AAW68154.11,|37682513|gb|AAQ98202.1|,|67553074|gb|AAY68663.1|,117046891 |gb|AAL34894.1|,|38892776jgb|AAR27767.1|,|56131603|gb|AAV80383.1|,|17046565|gb|AAL34601.11,|4324816|gb|AAD 17080.11,111761269|dbj |B AB19211.1], |12957307|gb|AAK09147.1|AF32

j 12957301 |gb]AAK09142.1 |AF32, |6016891 |dbj |BAA85228.1|3252940|gb|AAD12090.1||23986254|gb|AAL12203.11, |23986210|gb|AAL12176.1|, |23986238|gb|AAL12194.1|l23986224lgblAAL12185.ll, |11761283|dbj]BAB19223.1|5 |3252950|gb|AAD12099.1||3252970|gb|AAD 12117.11, |57869620|gb|AAW57665.11, |3252922|gb|AAD12074.11|63098355|gb]AAY32401.1|, |17046901|gb|AAL34903.1|5 |12957295|gb|AAK09137.1|AF32112957283 |gb|AAK09127.1 |AF32, 113569291 |gb|AAK31029.1 |AF28

|11761276|dbjjBAB19217.1|, |31559673 |dbj|BAC77496.1|, |11761584|gb|AAG38914.1||11761574|gb|AAG38905.1|, |27227854|dbj|BAC45027.1|, |62956389|gb|AAY23522.1||62956379|gb|AAY23513.1 j, |11761594|gb|AAG38923.1|} |13569271|gb|AAK31011.1|AF28

|82571223|gb|ABB83999.1|, |67553084|gb|AAY68672.11|3252930|gb|AAD12081.1], 113569251 |gb|AAK30993.1 |AF28|82571263|gb|ABB84035.1|, |68522107|gb|AAY98697.1||46486666|gb|AAS98769.11, |73913996|gb|AAZ91956.1|]58220893|gb|AAW68082.1], 117046675|gb|AAL34700.lj

|630983 83 |gb|AAY32426.1 j|1295733 l]gb]AAK09167.1]AF32

|27227844|dbj|BAC45018.11,117046755|gb|AAL34772.11,|51572107|gb|AAU06756.1|,|57338558|gb|AAW49353.1|,|59003660]gb|AAW83656.1|,115281423 |gb| AAK94213.11AF36,112957337]gb|AAK09172.1 |AF32,

|55139282|gb|AAV41303.1|, |73913757|gb|AAZ91742.1|, |59003630|gb|AAW83629.1||58220873|gb|AAW68064.1|, |17046861|gb|AAL34867.1|, |59003521|gb]AAW83531.l!|38892692|gb|AAR27692.11, |68521967|gb|AAY98571.11, |55139302|gb|AAV41321.1 j|55139274|gb|AAV41296.11, |38892673|gb|AAR27675.11, 112957373|gb]AAK09202.1 |AF32112957367|gb|AAK09197.11AF32, |3252960|gb|AAD12108.1|, |62956398|gb|AAY23530.1||4324873|gb|AAD17137.1|, |4324864|gb|AAD17128.1|, |68522057|gb|AAY98652.1||17046841 |gb|AAL34849.1 ], |68522147|gb|AAY98733.11, |58220883|gb|AAW68073.1 jl58220863lgbjAAW68055.il, |17046911|gb|AAL34912.1|, |13569321|gb|AAK31056.1|AF28

|63098423|gb]AAY32462.1|,|58220992|gb|AAW68171.1|,|82571214|gb|ABB83991.1|,|38892612|gb|AAR27621.11,|17046705|gb|AAL34727.1|,|63098393|gb|AAY32435.1|,138892701 |gb|AAR27700.11,|73913895|gb|AAZ91866.1|,

|82571352|gb|ABB84115.11,|37682602|gb|AAQ98282.1|,|38892629|gb|AAR27636.1|,|38892657|gb|AAR27661.11,|73913968|gb|AAZ91931.1|,117046625|gb | AAL34655.1],|59003650|gb|AAW83647.1|,|63098298|gb|AAY32350.1|,

|73913846|gb|AAZ91822.1||37682553 |gb|AAQ98238.11|63098316|gb|AAY32366.11|68522027|gb|AAY98625.1||63098288|gb|AAY32341.1||82571342|gb|ABB84106.1||67553034|gb|AAY68627.1|116751262|gb|AAL05337.1182571302|gb|ABB84070.1|,

590035111gb|AAW83522.1|,

59003621 jgbjAAW83621.1 j,

38892785jgb|AAR27775.1|,

59003591 jgbjAAW83 594.11,

68521937jgbjAAY98544.il,

63098365jgbjAAY32410.1|,

82571194jgbjABB83973.1|,

63098308jgbjAAY32359.il,

68521957jgb|AAY98562.lj,

73913787jgbÍAAZ91769.1|,

5900358ljgbjAAW83585.il,

68522017|gbjAAY98616.11,

73913934jgbÍAAZ91901.1|,

58220903 |gbjAAW68091.11,

|55139332|gb|AAV41347.1|,|63098336|gb|AAY32384.11,|73913987|gb|AAZ91948.1|,159003611 |gb|AAW83612.11,117046765|gb| AAL34781.11,|57338544|gb|AAW49341.11,|55139255|gb|AAV41279.1|,|82571372|gb)ABB84133.1|,|73913856|gb|AAZ91831.1|,

|68521987|gb|AAY98589.1|37909405jgbjAA065566.1|73913885|gb|AAZ91857.1|5900357 l|gb|AAW83576.1|67552999|gb|AAY68596.1|46486630|gb|AAS98737.1|82571204|gb|ABB83982.1|58220913|gb|AAW68100.1|82571362|gb|ABB84124.1

|68521997|gb|AAY98598.1|, |13569221|gb|AAK30966.1|AF28

|82571243|gb|ABB84017.1|,|73913905|gb|AAZ91875.1|,|67553017|gb|AAY68612.1|,|55139311|gb|AAV41329.1|,

|57869628|gb|AAW57672.1|73913777|gb|AAZ91760.1|38892639|gb|AAR27645.1|73913797|gb|AAZ91778.1167553114|gb|AAY68699.1

|17046871 |gb|AAL34876.11,17046605jgbjAAL34637.il,' |55139343|gb|AAV41357.1|, |12957349|gb|AAK09182.1|AF3212957343|gb|AAK09177.1|AF32, |18643013|gb|AAL74048.1|, |67553104|gb|AAY68690.1

67552979|gb|AAY68578.1|,

58220933jgbjAAW68118.lj,

38892665jgbjAAR27668.il,

82571332|gbjABB84097.11,

5900354ljgbjAAW83549.il,

58220943ÍgbjAAW68127.lj,

|68522087|gb|AAY98679.1|73913807|gb|AAZ91787.1jl7046825|gbjAAL34835.1j 17046615|gbjAAL34646.1117046595|gb jAAL34628.1|38892729|gb|AAR27725.1

|82571322|gb|ABB84088.1|,|67553044|gb|AAY68636.1|,|3 8892683 |gb|AAR27684.1|,|68521947|gb|AAY98553.lj,|32344849|gb|AAM82304.1|,|37935584|gb|AA065557.1|,12957325|gb|AAK09162.1|AF32, |22596255|gb|AAN03045.1|AF45

68522097|gb|AAY98688.11, |78172827|gb|ABB29361.1|, |58221040|gb|AAW68214.158220923|gb|AAW68109.11, |82571233|gb|ABB84008.1|, |12957259|gb|AAK09107.1|AF3212957247|gb|AAK09097.1 |AF32, |26000257|gb|AAN75292.11, |63098413|gb|AAY32453.117046795|gb|AAL34808.1|, |13172885|gb|AAK14233.1|, |1132101 l|gb|AAG34004.182303319|sp|Q9DQ13|Q9DQ13_9, |11321021|gb|AAG34013.1

11321031|gb|AAG34022.1|, |11321001|gb|AAG33995.1|, |32344839|gb|AAM82295.138892622jgbjAAR27630.11, |37682563|gb|AAQ98247.11, 112957277|gb|AAK09122.1 |AF32

|82571399|gb|ABB84157.1|, |82571253|gb|ABB84026.1115281502|gb|AAK94284.1 |AF36, |63098374|gb|AAY32418.1|51572097|gb| AAU06747.11,|1353864|gb|AAB36503.1|,117046665|gb|AAL34691.11,|46486657|gb|AAS98761.lj,|11761286|dbj|BAB19225.1|,

|12957313|gb|AAK09152.1|AF3212957289jgbjAAK09132.ljAF32, |7321137|emb|CAB82220.1|, 11704692l|gb|AAL34921.1'32261459|gb|AAP76524.1|, |68522037|gb|AAY98634.1|, |13569261|gb|AAK31002.1|AF2859003601 |gb|AAW83603.1|, |56193060|gb|AAV84139.1|, |57901091|gb|AAW57857.156193007|gb|AAV84112.1|, |55139293|gb|AAV41313.1|, |32261498|gb|AAP76559.12259631 l|gbjAAN03094.1|AF45, |45738223|gb|AAS75881.1|, j45738213|gb|AAS75872.11704685ljgbjAAL34858.il, |82571292|gb|ABB84061.1|, |59003531|gb|AAW83540.168522047|gbjAAY98643.1|, |15281473|gb|AAK94258.1|AF36, |63098433|gb|AAY32471.182571390|gb|ABB84149.1|, |1356933l|gb|AAK31065.1|AF28, |57338566|gb|AAW49360.146486639|gb|AAS98745.1|, |58220982|gb|AAW68162.1|, |73913767|gb|AAZ91751.1

68522007|gb|AAY98607.1|,38892757ÍgbjAAR27750.1|,63098326jgbjAAY32375.il,73913 876|gb|AAZ91849.11,32261488jgb|AAP76550.11,57338551 jgbjAAW49347.11,37682484jgb|AAQ98176.1|,37682503 jgb| AAQ98193.11,

|82571282|gb|ABB84052.1|17046585|gb|AAL34619.1|68522127|gb|AAY98715.1|82571382|gb|ABB84142.1|32261468|gb|AAP76532.1|13569301|gb|AAK31038.1|AF28, |13569241|gb|AAK30984.1|AF28,

|30269369|gb|AAP29647.11, 113569281 |gb|AAK31020.1 |AF28, |45361078|gb|AAS59308.11,|31559645jdbj |B AC77471.11, |17046881|gb|AAL34885.1|, |17046715|gb|AAL34736.1|;|56193078|gb|AAV84148.1|, |31559627|dbj|BAC77455.1|, |61102604|gb|AAX37741.1||61102596|gb|AAX37734.1|, |61102588|gb|AAX37727.1|, |38892766|gb|AAR27758.1l|55139264|gb|AAV41287.1|, |22596527|gb|AAN03286.1|AF45, |56193043|gb|AAV84130.1j17046735jgbj AAL34754.11, |37682592|gb|AAQ98273.1|17046655|gb|AAL34682.1l26000277lgbjAAN75310.il, |12957319|gb|AAK09157.1|AF32, |73913978|gb|AAZ91940.1||14530230|gb|AAK65964.1|AF28, |17981622|gb|AAL51092.1

112957361 |gb|AAK09192.1 |AF32, |12957355|gb|AAK09187.1|AF32

|12957253|gb|AAK09102.1|AF32, |67553094|gb|AAY68681.1|, |77167543|gb|ABA62731.1||77168161|gb|ABA63040.1|, |77167837|gb|ABA62878.1|,|68522137|gb| AAY98724.11, |56193094|gb|AAV84157.11,|48476376|gb| AAT44410.11, 11477916|gb| AAB05541.11,|5668957|gb|AAD46101.1|AF076, |1477914|gb|AAB05540.1|,|1477884|gb|AAB05525.1|, |1477882|gb|AAB05524.1|,|82278725|sp|036205|036205_9, |2393865|gb|AAB70160.1|,|82279702]sp|042054|042054_9, |24753964|gb|AAN64089.1|3

11477798|gb | AAB05482.11,ll477870lgblAAB05518.ll,|2393859|gb|AAB70157.11,|77168047|gb]AB A62983.11,|57545356|gb|AAW51581.1|,

|1477794|gb|AAB05480.1|,11477874|gb|AAB05520.11,|56193026|gb|AAV84121.1|,|77168250|gb| ABA63084.11,|77167375 |gb| ABA62647.11,

|25166809|gb|AAN73600.1|AF48, |2194190|gb|AAB61128.1|,|66864704|gb|AAY57430.11, |66864694|gb|AAY57421.11,

|4324834|gb|AAD17098.11,117046635|gb|AAL34664.11,|77167327|gb|AB A62623.11,]77168282|gb|ABA63100.11,|77167549|gb|ABA62734.1|,|77167631 |gb|AB A62775.1 j,

|77167563|gb|ABA62741.1||63081180|gb|AAY30342.11|1477910|gb|AAB05538.lj|1477912|gb|AAB05539.1||2393857|gb|AAB70156.1 j|2393863|gb|AAB70159.1||2393867|gb|AAB70161.1||1477876|gb|AAB05521.1|]1477872|gb|AAB05519.1||77167479|gb|ABA62699.11|77168175lgb|ABA63047.1||77167373 |gb|ABA62646.11|771675 81 jgbj ABA62750.1 j|77168141|gb|ABA63030.1||4324840jgb|AAD17104.1||77168167|gb|ABA63043.1||37682454|gb|AAQ98149.11|77167871 |gb| ABA62895.11|77167975|gb|ABA62947.1||17046545|gb|AAL34583.1||61102678|gb|AAX37805.1||45361068|gb|AAS59299.1|

|4324825|gb|AAD17089.1|,117046775 |gb|AAL34790.11,|77167523|gb | AB A62721.11,|77167501|gb|ABA62710.1|,l77167527lgblABA62723.ll,|17046805|gb|AAL34817.1|,|77168296|gb|ABA63107.1 ], |25167039|gb|AAN73807.11AF48,|25167029|gb|AAN73798.1 jAF48, |55735970|gb|AAV59701.1|,|57901061|gb|AAW57830.1|3 |15788250|gb|AAL07702.1|, |25166657|gb|AAN73464.1|AF48|25166667|gb| AAN73473.1 |AF48, |22596577|gb|AAN03331.1|AF45

|77168384|gb|AB A63151.11, |77168187|gb|ABA63053.11, |77167339|gb|ABA62629.11|61102636|gb|AAX37769.1|, |61102628|gb|AAX37762.1|, |57869657|gb|AAW57698.1||57869591 |gb|AAW57639.1|, |25167059|gb|AAN73825.1|AF48

|25166819)gb|AAN73609.1 |AF48, |82307224|sp|Q9WA46|Q9WA46_9

|4539050|emb|CAB39740.1|, |4539037|emb|CAB39919.1|, |25166697|gb|AAN73500.1|AF48|3287165|emb|CAA75986.110, |37935902|gb|AA047148.1|0, |3287129|emb|CAA75962.1|0|3287124|emb|CAA75958.1|0, |3287160|emb|CAA75982.1|0, |3287119|emb|CAA75954.1|0|14041639|emb|CAC38423.1|0, |14041629|emb|CAC38432.1|0

|3287083|emb|CAA75938.1|0, |37935843|gb|AA047096.1|0, |463061|gb|AAA99881.1||13172678|gb|AAK14191.1|0, |13172696|gb|AAK14206.1|0, |13172690|gb|AAK14201.1|0

|51599142|gb|AAU08226.1|0, |37935972|gb|AA047210.1|0|37935913|gb|AA047157.1|0, |37935943|gb|AA047184.1|0|3287149|emb|CAA75978.1|0, |37935893|gb|AA047140.1|0

|3287114|emb|CAA75950.1|,|45644392|gb]AAS72946.1|0,113172702|gb|AAKl 4211.110,|3287144|emb|CAA75974.1|0,|3287104|emb|CAA75942.1|0,|3 793 5953 |gb|AA047193.110,|37935863 jgb | AA047114.1 jo,|13172714|gb|AAK14221.1|,|37935962|gb|AA047201.1|0,j 13172684|gb|AAK14196.1|0,|77167725|gb|ABA62822.1|,115281453 |gb|AAK94240.1 |AF36,

|37935873 |gb|AA047123.110, |13172708|gb|AAK14216.1|0

|3287109|emb|CAA75946.1jo, [3287139|emb|CAA75970.1 jo|37935923 |gb | AA047166.1 jO, |469243|gb|AAA44862.1|0

|3287134|emb|CAA75966.1 JOs |16755647|gb|AAL28059.1|0|37935982|gb | AA047219.110,|3793 5882|gb|AA047131.110,|37935853|gb|AA047105.1|0,17716821 l|gb|ABA63065.1|,

|3287078|emb|CAA75934.110|37935933 |gb|AA047175.110|77168332|gb|ABA63125.1||51572126|gb|AAU06773.lj177167821 |gb|ABA62870.1|38679152|gb|AAR26405.1

|5668884|gb|AAD46046.1 |AF075,|22596321 |gb|AAN03103.1 |AF45, |1160071|emb|CAA92889.1|, |77167897|gb|ABA62908.1||25166969|gb|AAN73744.1 |AF48, |37682474|gb|AAQ98167.11

|25166989|gb|AAN73762.1 |AF48, |1160099|emb|CAA92903.1|, |39777397|gb|AAR30977.1||38326773 |gb|AARl 7515.11, |25166632|gb|AAN73441.1 |AF48

|25167019|gb|AAN73789.1 |AF48, |25167009|gb|AAN73780.1 |AJF48

|25166829|gb|AAN73618.1|AF48, |25166779|gb|AAN73573.1|AF48

1135693 ll|gb|AAK31047.1|AF28, |71726035|gb|AAZ39164.1|, |32261478|gb|AAP76541.1|

|38892747|gb| AAR27741.1|,177167891 |gb| ABA62905.1|,|29119339|gb|AA063253.1|,|77168386|gb|ABA63152.1|,|3327801|gb|AAC41190.1|,|3327795|gb|AAC41187.1 j,|3327787|gb|AAC41183.1|,|3327777|gb|AAC41178.11,|3327781 |gb| AAC41180.1 j,|3327560|gb|AAC41072.1 j,|3327570|gb|AAC41077.1|,|3327546|gb|AAC41066.11,|3327568|gb|AAC41076.1|,|3327562|gb| AAC41073.11,|13540165|gb|AAK29333.1|,|5001967|gb|AAD37234.1|,|5001975|gb| AAD37238.11,|5001947|gb|AAD37224.1|,|5001935|gb|AAD37218.1|,|5001917|gb|AAD37209.1],|5001973|gb|AAD37237.1|,

|63098346|gb|AAY32393.1|,|78172834|gb|ABB29367.1|,|77168382|gb|ABA63150.11,|77168147|gb| AB A63033.11,|3327799|gb|AAC41189.11,|3327793 |gb|AAC41186.1|,|3327783|gb|AAC41181.1|,|3327775|gb|AAC41177.1|,|3327785|gb|AAC41182.1|,|3327558|gb|AAC41071.1|,|3327555|gb|AAC41070.1|,|3327544|gb|AAC41065.1 j,|3327550|gb|AAC41068.1|,|25166709|gb|AAN73510.1 |AF48,|5001987|gb|AAD37244.11,|5001957|gb|AAD37229.1|,|5001965|gb|AAD37233.1|,|5001945|gb j AAD37223.11,|5001927|gb|AAD37214.1|,

|71725955|gb|AAZ39092.1111160043 |emb|CAA92875.11|77167873|gb|ABA62896.lj|3327803|gb|AAC41191.1||3327797|gb|AAC41188.1||3327791 |gb|AAC41185.1||3327779|gb|AAC41179.11|3327789|gb|AAC41184.11j3327773|gb|AAC41176.1||3327564|gb|AAC41074.1 j|3327552|gb|AAC41069.1||3327548|gb|AAC41067.11|3327566|gb|AAC41075.11|386791611gb|AAR26413.1||5001977|gb|AAD37239.1 j|5001985|gb|AAD37243.1||5001955|gb|AAD37228.1||5001937|gb|AAD37219.1|(5001925|gb| AAD37213.11

|5001915|gb|AAD37208.1|, |82307158|sp|Q9W8N4|Q9W8N4_9

|5001963|gb|AAD37232.1|,|25166879|gb|AAN73663.1 |AF48, 11772628|gb|AAC32296.11,177167953 |gb|ABA62936.11, |77167333 |gb|ABA62626.11,|73919591|sp|P19555|VPR_HVlS, |1171168|gb|AAA86249.1|,

|77167545|gb|ABA62732.1|,|77167323|gb|ABA62621.11,|11177334|gb|AAG32236.11,jl 1177328|gb|AAG32233.1|,|11177320|gb|AAG32229.11,|11177322|gb|AAG32230.1 j,|27446728|gb|AAL62477.11,

|77167393|gb|ABA62656.1|,111177344|gb| AAG32241.11,|11177332|gb|AAG32235.1|,|11177326|gb|AAG32232.1|,|11177317|gb|AAG32228.1|,|11177342|gb|AAG32240.1 j,|24754007|gb|AAN64125.1|,

|5001983|gb|AAD37242.1||57545368|gb|AAW51587.11|33438571|gb|AAA45066.2||38570384|gb|AAR24630.1||57545316|gb|AAW51561.1 j|11177336|gb|AAG32237.1||11177330|gb|AAG32234.1|j 11177324|gb|AAG32231.11111177340|gb|AAG32239.11Ílll77338|gb|AAG32238.1||77168256|gb|AB A63087.11|45360161|gb|AAS59197.1[,|77167609|gb|ABA62764.1|,|77l67775|gb|ABA62847.1 j,|71726005|gb|AAZ39137.1|,|71725975|gb|AAZ39110.lj,|77167629|gb|ABA62774.1|,|2393812|gb|AAB70133.1|,l2393810lgbjAAB70132.ll,|2393798|gb|AAB70126.1|,

|77167883 |gb| AB A62901.1|7716791 l|gb|ABA62915.1|77167505|gb|ABA62712.1|71725985|gb|AAZ39119.1|71726045jgb j AAZ39173.1|2393816|gb|AAB70135.1

|77168286|gb|ABA63102.1|,|77167743|gb|ABA62831.11,|77167713|gb|ABA62816.1|,|77167819|gb|ABA62869.1|,|77168183|gb|ABA63051.1|,|1185548|gb|AAA87878.1|,|2393808|gb|AAB70131.1|, |82279708|sp|042077|042077_9|2393806|gb|AAB70130.1|, |2393802|gb|AAB70128.1|2393794|gb|AAB70124.1|,|82279700|sp|042035|042035_9, |2393800|gb|AAB70127.1|,|2393796|gb|AAB70125.1|, |2393790|gb|AAB70122.1|,

|57545288|gb|AAW51547.11,|7416692|dbj |B AA93986.113|5001941|gb|AAD37221.1|,|500191 l|gb| AAD37206.il,|77167827|gb|ABA62873.1|,|7416696|dbj|BAA93988.1|,|77167843|gb|ABA62881.1|,|38570382|gb|AAR24629.11,|38570390|gb|AAR24633.11,|3218174|emb|CAB05091.1|,11477808 |gb|AAB05487.11,|1477800|gb|AAB05483.1|,|77167925|gb|AB A62922.11,1139391 |sp|P05950|VPR_HVlMN, |328035|gb|AAA44855.1|,|77168027|gb|ABA62973.1|, |77167935|gb|ABA62927.1|,|77167453 |gb|ABA62686.11, |22532144|gb|AAM97855.1 |AF46

|22532134|gb|AAM97846.1 |AF46, |38491784|gb|AAR22163.1|, |17352347|gb|AAL01566.1||62467692|gb| AAX83948.11, |51950723|gb|AAU14915.1|, |14290032|gb|AAK59215.1||51950713|gb|AAU14906.1|, |15788241|gb|AAL07694.1|, |9931093|emb|CAC05364.1||37682533|gb|AAQ98220.11, |6651458|gb|AAF22310.1|AF193, |74315725|gb|ABA02453.1||38491902|gb|AAR22269.1|, |38679144|gb|AAR26398.1|, |38679135|gb|AAR26390.1||22596487|gb|AAN03250.1|AF45, |5668914|gb|AAD46068.1|AF076

|8886635|gb|AAF80534.1|AF179, |15209255|emb|CAC51034.1|, |38491757|gb|AAR22139.1||38491737|gb|AAR22121.1|, |18073404|emb|CAC87995.1|, |38491873|gb|AAJR22243.1||22596467|gb|AAN03232.1|AF45, |15281433|gb|AAK94222.1|AF36

|61102563|gb|AAX37706.1|, |22596371|gb|AAN03148.1|AF45, |57869545|gb|AAW57598.1||22596422|gb|AAN03193.1 |AF45, |77167931 |gb|ABA62925.11

|22596477|gb|AAN03241.1|AF45, |5305345|gb|AAD41599.1|AF071

|3808274|gb|AAD13361.1|, |3808264|gb|AAC69300.1|, |3808254|gb|AAC69291.1||61102663 |gb|AAX37792.11, |61102570|gb|AAX37712.1|, |61102547|gb|AAX37692.1|jl890687|gb|AAC97544.11, |25166929|gb|AAN73708.1|AF48, |37682523|gb|AAQ98211.1||31980419|dbj|BAC77740.1|, |31980409|dbj|BAC77731.1|, |57869554|gb|AAW57606.1||25166769|gb| AAN73564.11AF48, |3 8491883 |gb|AAR22252.11

|22596265|gb|AAN03054.1 |AF45, |22596401 |gb|AAN03175.1 |AF45

12259633 l|gb|AAN03112.1 |AP45, |22596434|gb|AAN03203.1|AF45

|61102620|gb|AAX37755.1|, |61102612|gb|AAX37748.1|, |22596381|gb|AAN03157.1|AF45|61102555|gb|AAX37699.1|, |61102523|gb|AAX37671.1|, |22596361|gb|AAN03139.1|AF45

|77167577|gb|ABA62748.1|,|7416698|dbj|BAA93989.1|,j 1160051 |emb|CAA92879.11,|5001921|gb|AAD37211.1|,|5001979|gb|AAD37240.1|,|38570380|gb|AAR24628.11,|34811837|gb|AA040780.1|,|38570376jgb|AAR24626.1|,|7416690|dbj |B AA93985.11,|77168292|gb|ABA63105.1|,|77167747|gb|ABA62833.1|,|1477804|gb|AAB05485.1|,|77168322|gb|ABA63120.11,

Í2393792|gb|AAB70123.1|2393804|gb|AAB70129.1|2393814|gb|AAB70134.1|57545286|gb|AAW51546.1|1160053|emb|CAA92880.1|5001931|gb|AAD37216.1[5001989|gb|AAD37245.1|38570386|gb|AAR24631.1|77168069|gb|ABA62994.1|38570396|gb|AAR24636.1|7416694|dbj |B AA93987.1 j|771673 83 |gb|AB A62651.1|57545300|gb|AAW51553.1||1477806|gb|AAB05486.1|11477802|gb|AAB05484.11|77167569|gb|ABA62744.1||57545348 |gb|AAW51577.11|77168041|gb|ABA62980.1||22596245|gb|AAN03036.1 |AF45,|25166789|gb|AAN735 82.1 |AF48,|3808244|gb|AAC69282.11, |39777417|gb|AAR30995.11,

|39777427|gb|AAR31004.1 j,|5305481|gb|AAD41669.1|AF075,1*7114857l|gb|AAZ28902.1|, |22596391|gb|AAN03166.1|AF45, |38491774|gb|AAR22154.1|,|38491747|gb|AAR22130.11, |22532295|gb|AAM97888.1|AF49, |46946847|gb|AAT06637.1|,118699152|gb|AAL78423.1 |AF41, |56609314|gb|AAW03268.1|,

118699129|gb| AAL78403.1 |AF41, 118699189|gb|AAL78449.1 |AF41,

|18699137|gb|AAL78410.1|AF41, |18699144|gb|AAL78416.1|AF41,

|22596286|gb|AAN03072.1|AF45,|25166687|gb| AAN73491.1 |AF48,|22596275 |gb|AAN03063.1 |AF45,j22596447|gb|AAN03214.1|AF45,|22596567|gb|AAN03322.1|AF45,

|56609330|gb|AAW03282.1|, |56609324|gb|AAW03277.1|,|56609264|gb|AAW03223.1|, |56609244|gb|AAW03205.1|,|41353555|gb|AAS01342.1|, |56609294|gb|AAW03250.1|,|22596457|gb|AAN03223.1|AF45,|25166979|gb|AAN73753.1 |AF48,|22596497|gb|AAN03259.1|AF45,|38491765 |gb|AAR22146.11, |22532285|gb|AAM97879.1 |AF49,

|18073414|emb|CAC88004.11, |1899133|gb|AAC57013.1|, |46946838|gb|AAT06629.1|,|46946829|gb|AAT06621.1|, |14530240!gb|AAK65973.1|AF28,|14530248|gb|AAK65980.1|AF28, |37682434|gb|AAQ98131.1|,|5733945|gb|AAD49783.1|AP1073 |7452902|emb|CAB86368.1|,|1478060|gb|AAB51139.1|, |45361169|gb|AAS59373.1|,|5531678|gb|AAD44397.1|AF055,|5531654|gb|AAD44376.11AF055,|3132814|gb|AAC29080.11, |3132804|gb|AAC29071.11, |46946862|gb|AAT06650.11,|33390882|gb|AAQ17101.1|, |38491569|gb|AAR21972.1|, |25807940|gb|AAN74527.1|,|25807930|gb|AAN74518.1 j, |74315772|gb|ABA02495.1|, |5531670|gb|AAD44390.1|AF055,|5531662|gb|AAD44383.1|AF055, |5305578|gb|AAD41712.1|AF097,

|5531646|gb|AAD44369.1 |AF055, |38491599|gb|AAR21999.1|, |56609341|gb|AAW03291.1|,

|56609274|gb|AAW03232.11,|56609304|gb|AAW03259.1|,|78172854|gb|ABB29385.1|,|45361158|gb|AAS59367.1|,|38491503|gb|AAR21913.1|,113560262|dbj |B AB40913.110,

|24181491|gb|AAN47112.1|,|74315762|gb| ABA02486.1 j,|45361178|gb|AAS59379.1|,|3 8491716|gb|AAR22103.1 j,|5305562|gb|AAD41698.1|AF097,|5305570|gb|AAD41705.1|AF097,

|56609284|gb|AAW03241.11,|7657892|emb|CAB89146.11,|71794616|emb|CAI28856.1|,|38491651 |gb| AAR22045.11,|38491631 |gb|AAR22027.1 j,|45361190|gb|AAS59384.1|,|38491698|gb|AAR22087.1|,|38491579|gb|AAR21981.1|,|38491690|gb |AAR22080.11,

|56609254|gb|AAW03214.1|,|38491726|gb|AAR22112.1\,114289986|gb|AAK59174.11,|38491513|gb|AAR21922.1|,|13517086|dbj|BAB40424.1|,|7452912|emb|CAB86377.1|,|38491616|gb|AAR22014.1|,l38491530lgblAAR21937.ll,|1732479|gb|AAB38827.1|,

|6690770|gb|AAF24329.1 |AF197, |38491706|gb|AAR22094.11,|45644384|gb|AAS72939.1|, |38491844|gb|AAR22217.1|,

|38491912|gb|AAR22278.1|,|38491892|gb|AAR22260.1|,|37682981 |gb|AAQ98543.11,|38491863|gb|AAR22234.1|,|38491539|gb|AAR21945.1|,137496501 |emb|CAD48457.11,|5931495 |dbj|B AA84672.1|3|28933405 |gb|AA062619.1 |AF46,

|38491549|gb|AAR21954.1|,|23194122|gb|AANl 5030.1|,|37682892|gb|AAQ98464.1|,|38491854|gb|AAR22226.1|,|38491661|gb|AAR22054.1|,137496485 |emb|CAD48443.11,

[38491641 |gb|AAR22036.11,|3 8491493 |gb|AAR21904.1 j,|3 8491671 |gb|AAR22063.11,|6466843|gb|AAF13058.1|,|38491621 |gb|AAR22018.1 j,|38491559|gb|AAR21963.1|,|38491522|gb|AAR21930.1|,|38491608|gb|AAR22007.1|,|45361126|gb|AAS59344.1|,115982648|gb|AAL09936.11,|71794626|emb|CAI28865.11,|38491589|gb|AAR21990.1|,|37683001 |gb|AAQ98561.11,|33328323|gb|AAQ09612.1|2,]38491681|gb|AAR22072.1|,|14289996|gb|AAK59183.1|,|1537054|gb|AAC55462.1|,

|6690756|gb|AAF24315.1 |AF197,111066501 |gb|AAG28616.1 |AF25,111066491 |gb|AAG28607.1 |AF25,

|6690763|gb|AAF24322.1|AF197, |11761604|gb|AAG38932.1|,

|37682971 |gb| AAQ98534.1|,|37682804|gb|AAQ98387.1|,118844740|dbj |BAB85462.11,|37682882|gb|AAQ98455.1|,|37682871 |gb|AAQ98447.1 j,|33328191 |gb|AAQ09540.1j,|37682714|gb|AAQ98306.1|3

|37682824|gb|AAQ98405.1|,|37682734|gb|AAQ98324.1 j,|18844730|dbj|BAB85453.1|,|37682864|gb|AAQ98441.11,|45361150|gb|AAS59362.11,|22297043 |gb| AAM94499.11,|37682961 |gb|AAQ98525.11,

|82284899|sp|Q6JNE4|Q6JNE4_9, |45361138|gb|AAS59353.1|,]57869667|gb|AAW57707.11, |57869732|gb|AAW57765.1|,

|57869687|gb|AAW57725.1|,|37682764|gb|AAQ98351.11,|31559635|dbj |B AC77462.1|,|37682844|gb|AAQ98423.1|,|57869696|gb|AAW57733.1|,|38491834|gb|AAR22208.1|,|45361104|gb|AAS59326.1|,137682941 |gb|AAQ98507.11,|37682921 |gb|AAQ98489.1j,|33328201 |gb|AAQ09549.1j,|46243167|gb|AAS83693.1|,|3676484|gb| AAC61989.11,|52421739|gb|AAU45378.1|,

|37682913|gb|AAQ98482.1|,|77167661|gb|ABA62790.1|,|37682724|gb|AAQ98315.1|,|78100203 |gb|ABB20906.11,|45361202|gb|AAS59393.1|,|57869677|gb|AAW57716.1|,137682903 |gb| AAQ98473.1|,|37682794|gb|AAQ98378.1|,|37682834|gb|AAQ98414.1|,|57901111 |gb|AAW57875.11,(46243159|gb|AAS83686.1|,114290023|gb|AAK59207.11,|37496493|emb|CAD48450.1|,|9368382|emb|CAB98171.1|,

|14209301|dbj|BAB55910.1||11761564|gb|AAG38896.1|137682814|gb|AAQ98396.11137682991 |gb|AAQ98552.1 j|37682744|gb| AAQ98333.1 j|45361116|gb|AAS59335.1|119908410|gb|AAL96765.11|3768293 l|gb|AAQ98498.11|37682774|gb|AAQ98360.1||30720410|gb|AAP33678.11|57869723|gb|AAW57757.1||37682754|gb|AAQ98342.11|31559683|dbj|BAC77505.1||37682704|gb|AAQ98297.11|57869714|gb|AAW57749.11|5931486|dbj|BAA84664.1113768295 l|gb|AAQ98516.11|3768301 l|gb|AAQ98570.1||37682784|gb|AAQ98369.1||37682854|gb|AAQ98432.1||3676492|gb|AAC61996.11|38491929|gb| AAR22293.11|14290014|gb|AAK59199.1||57545340|gb|AAW51573.11|4336343|gb|AAD17769.1|

|3779264|gb|AAD03312.11,|4336333|gb|AAD17759.1|, |46946854|gb|AAT06643.1|, |22596341|gb|AAN03121.1|AF45|6580989|gb|AAFl 8398.1 |AF190, |3114568|gb)AAD03186.11, |37682543|gb|AAQ98229.11

|8920155|emb|CAB96341.1|,|3403219|gb|AAC29053.1|,|3114551 |gb|AAD03171.11,116118377|gb| AAL12742.11,115788280|gb| AAL07729.11,|45360141 |gb|AAS59179.11,|29119318|gb|AA063234.11,|47118213|gb|AATl 1204.1|,jl6118343lgblAAL12712.il,|47118263 |gb|AATl 1249.11,|16118397|gb|AAL12760.1|,|15788270|gb|AAL07720.1|,|45360192|gb|AAS59225.1|,|47118243 |gb|AATl 1222.1|,Í32189802|gbjAAP75713.1|,|37682572jgbjAAQ98255.1|,177167909|gb|ABA62914.11,|77167993IgbjAB A62956.11,|77167435jgbjABA62677.lj,|23392759Íemb|CAD26717.1|,Í27446732jgb|AAL62479.11,

|3288392|emb|CAA06812.11,|340321 l|gb| AAC29046.1|,|47118223|gb|AAT11213.1|,|45360171 |gb| AAS59206.11,|16118353jgblAAL12721.il,145360151 |gb|AAS59188.1|,|16118367|gb|AAL12733.1|,

14702739 l|gb|AAT08771.11|14579615|gb|AAK69332.1||47118253|gb|AATl 1240.1]|14579595|gb|AAK69314.1|115787962|gb|AAL07552.11|29119327|gb|AA063242.1||16118314|gb|AAL12688.lj

116118331 |gb|AAL12702.11, |6090968|gb|AAF03415.1 |AF075|5668942|gb|AAD46090.1 |AP077, 115788290|gb|AAL07738.11

|45360212|gb|AAS59243.1||14579605|gb|AAK69323.lj|9368372|emb|CAB98189.1||38491824|gb | AAR22199.11|45360181|gb|AAS59215.1|

|16118264|gb|AAL12643.1|,|15788260|gb|AAL07711.1|,|6643029|gb|AAF20390.1|,|14290005|gb|AAK59191.1|,|16118304|gb|AAL12679.1|,|5305357|gb|AAD41609.1|AF071, |62946404|gb|AAY22381.1||77168097|gb|ABA63008.11, |77168049|gb|ABA62984.11|77168219|gb| ABA63069.11, (77167495|gb|AB A62707.11(77167777jgbjABA62848.1 j, |77168051 |gb|ABA62985.1 j

|82295417|sp|Q8AC04|Q8AC04_9|23392757|emb|CAD26716.11, |23392755|emb|CAD26715.1||77168276|gb|AB A63097.11, |77167691 |gb|ABA62805.11|77167791 |gb|AB Α62855.11,|77168189|gb|ABA63054.1|,11072090|gb|AAC54546.11,|37681534|gb|AAQ97644.11,112964713IgbjAAKl 1285.1 j,|77167467|gb| ABA62693.11,|7416700|dbj|B AA93990.il,|3327540|gb|AAC41063.11,|3327536|gb|AAC41061.1|,13327521 |gb|AAC41055.1 j,|3327514|gb|AAC41052.1|,l3327488lgbjAAC41039.il,|3327530|gb|AAC41058.1|,|3327498|gb|AAC41044.1|,|3327494|gb|AAC41042. lj,|55735997|gb|AAV59725.1|,

|77167599|gb|ABA62759.1|,|77167695 |gb|ABA62807.11,|3002889|gb|AAD03243.11,|37677777|gb | AAQ97455.11,|1160049|emb|CAA92878.1|,112964711 |gb|AAKl 1284.11,|7416702|dbj |B AA93991.1 j,|3327490|gb|AAC41040.1|,|3327534|gbÍAAC41060.lÍ,|3327519|gb|AAC41054.1 j,l3327510jgblAAC41050.il,j3327528|gbjAAC41057.lj,Í3327506|gbÍAAC41048.lj,Í3327512jgb jAAC41051.1 j,|3327508|gb|AAC41049.1|,150404191 |gb|AAT76861.11,

|25166759|gb|AAN73555.1|AF48, |77167703|gb|ABA62811.11,|38491919|gb|AAR22284.1|, |23394930|gb|AAN31651.1|

|16118254|gb|AAL12634.11,|77167717|gb|ABA62818.1|,|77168083 |gb|ABA63001.1 j,|57869601 |gb|AAW57648.1|,|77167395|gb|ABA62657.1|,|7416722|dbj |BAA94001.11,|82283749|sp|Q66MS6|Q66MS6

|7416684|dbj |BAA93982.11,|77168149|gb|ABA63034.11,|46254417|gb|AAS86175.1|,|77167583 |gb|ABA62751.1 j,|77167861 |gb|ABA62890.11,|7416718|dbj |B AA93999.11,9,

182283743 |sp|Q66MR4|Q66MR4_9, |7416720|dbj |BAA94000.11

|77167903 |gb IAB A62911.11,|77168288|gb|ABA63103.1|,|771673 35 jgb j AB A62627.1 j,j77167357jgbjABA62638.lj,j7716818ljgbÍABA63050.1|,Í3002862|gb|AAD03219.11,

|77167651 |gb| AB A62785.11,\Π 167869|gb jABA62894.11,|77168201 |gb|AB A63060.11,|77167905 |gb | AB A62912.1 j,|1160045|emb|CAA92876.1|,|77167779|gb|ABA62849.11,

|77167863 |gb|ABA62891.1|, 115281483 |gb|AAK94267.1|AF36,

|30038317|gb|AAP12630.1|,jll641105jgbjAAG38457.il,jll641103jgbjAAG38456.lj,jl5407142|gbjAAG32144.lj,Í57545298jgbjAAW51552.lj,|77167781 |gb|AB A62850.11,jl055033|gb|AAA81039.1|,|77167421 |gb|AB A62670.11,|2393846|gb|AAB70150.1|,|77167649|gb|ABA62784.11,Í77168023 jgbjABA62971.11,Í77167353|gbjABA62636.lj,Í77167805 jgbjABA62862.1 j,

|1160111 |emb|CAA92909.1|,|11641099|gb|AAG38454.1|,jl 1641101 jgb|AAG38455.1|,|57545302|gb|AAW51554.1|,177167613 |gb| ABA62766.11,|57545290|gb|AAW51548.11,

|14278628|pdb|lESX|A,|77167377|gb | AB A62648.11,|2393 842|gb|AAB70148.1|,|77167341 |gb|ABA62630.11,|3218479|emb|CAB05072.11,|77167853 |gb| AB A62886.1 j,|77167497|gb| ABA62708.11,

11160065|emb|CAA92886.11, |25166919|gb|AAN73699.1 |AF48,j25166729|gb|AAN73528.1|AF48, |77168191|gb|ABA63055.1|,

|77167309|gb|ABA62614.1j|77167419jgbjABA62669.1||3002853 |gb|AAD03211.11|77167807|gb|ABA62863.11]77167481 jgbjABA62700.11j77168125jgbÍABA63022.lj|3327504jgbjAAC41047.1]Í3327538|gbjAAC41062.1|j3327532jgbjAAC41059.ljÍ3327517ÍgbÍAAC41053.1|Í3327496|gb|AAC41043.ljj3327486jgbjAAC41038.ilÍ3327500jgbjAAC41045.ljj3327502jgbjAAC41046.ljj3327492jgbjAAC41041.lj|77168334jgbÍABA63126.ljl7716740ljgbjABA62660.il|1160057|embjcAA92882.1|13002871 |gb|AAD03227.lj|46254439|gb|AAS86190.1||3002843|gb|AAD03202.lj|77167413 |gb| ABA62666.1 j|77167405jgb j ABA62662.11|7416716|dbj jBAA93998.11|29119345|gb|AA063258.1|I, |77168225|gb|ABA63072.11Í77168310|gb|ABA63114.1 j|77167489jgbjABA62704.1 jj77168195jgbjABA63057.lj|77168304jgb|ABA63111.1||29119279|gb|AA063199.lj|57545324|gb| AAW51565.11|1160109|emb|CAA92908.lj|11641109|gb|AAG38459.ljjll641107|gb|AAG38458.ljÍl5407144jgbjAAG32145.lj|1185524jgbjAAA87866.lj|3218146|emb|CAB05077.11Í3218184jembjCAB05096.lj|3218475jembjCAB05070.lj|77167959|gb|ABA62939.1 j|2393828jgbjAAB70141.lj|57545274|gb|AAW51540.11|3218144|emb|CAB05076.11|77167769|gb|ABA62844.lj|7716735 l|gb|ABA62635.11|3218140|emb|CAB05074.11|77167997|gb|ABA62958.1||49472925 |gb|AAT66270.11,177167663 IgbjAB A62791.1],|77167741 |gb|ABA62830.1j,|2393830|gb|AAB70142.1|,|2393840|gb|AAB70147.1|,|2393836|gb|AAB70145.1|,|77167573 |gb|ABA62746.1|,157545314|gb|AAW51560.11,|77168029|gb| ABA62974.11,|77167875|gb|ABA62897.1 j,|829583|gb|AAA79679.1|,|829389|gb|AAA79528.1|,|829526|gb|AAA79632.1 j,|829403|gb|AAA79540.1|,|829576|gb|AAA79673. 1 j,|829554|gb|AAA79654.1|,l3218178lemblCAB05093.ll,11160075 |emb|CAA92891.11,

|77168235|gb|ABA63077.1|,l77167445lgblABA62682.ll,|2393838|gb|AAB70146.1|,|82279701 |sp|042045|042045_9,|2393832|gb|AAB70143.1|,|2393824|gb|AAB70139.1|,|1160027|emb|CAA92867.11,|77168328|gb|AB A63123.1 j,|77168324|gb|ABA63121.1|,l77167829jgblABA62874.il,|829569|gb|AAA79667.11,|829546|gb|AAA79647.11,(829518|gb|AAA79625.11,|829396|gb| AAA79534.1 j,|327817|gb|AAB03747.1|, |139388|sp|P20883|VPR_HVlJR,|1160033 |emb|CAA92870.11, |7416650|dbj |BAA93965.1

|3218176|emb|CAB05092.1|,|24753997|gb|AAN64116.1|,|25166849|gb|AAN73636.11AF48, |29893418|gb|AAP03071.1|,jll60041|emb|CAA92874.1|, |116003 l|emb|CAA92869.1|,

11160055 |emb|CAA92881.11,

|77168135|gb|ABA63027.1|77167735|gb|ABA62827.1|2393834|gb|AAB70144.1|2393871|gb|AAB70163.1|2393 869|gb|AAB70162.1|77167627|gb|ABA62773.1177168314|gb|ABA63116.1|77168356|gb|ABA63137.1|77167715|gb| ABA62817.1|77167809|gb|ABA62864.1|829562|gb|AAA79661.1|829538|gb|AAA79640.1|829510|gb|AAA79618.1|829381 |gb|AAA79521.1

|7416656|dbj|B AA93968.il,|29119308|gb|AA063225.1|,|1160023|emb|CAA92865.1|,|3327626|gb|AAC41103.1|,|3327612|gb|AAC41097.11,|3327606|gb| AAC41094.11,|3327600|gb|AAC41091.11,|3327594|gb|AAC41088.1|,|3327588|gb|AAC41085.1|,13327573 |gb|AAC41078.11,|3327620|gb| AAC41100.1 j,|3327580|gb|AAC41081.11,|77167685 |gb|ABA62802.1 ],15001951 |gb|AAD37226.11,|3218156|emb|CAB05082.11,|77168252|gb|ABA63085.1|,|77167389|gb|ABA62654.1|,|3327674|gb|AAC41127.1],|3327664|gb|AAC41122.1|,Í3327652|gb|AAC41116.1|,|3327638|gb|AAC41109.1|,|3327632|gb|AAC41 lOó.lj,|3327660|gb|AAC41120.1|,|3327648|gb|AAC41114.1|,|3327640|gb|AAC41110.11,|77167923 |gb | AB A62921.11,|77167601 |gb|ABA62760.11,|77168348|gb|ABA63133.1],

|77168300|gb|ABA63109.11,|29119259|gb|AA063181.11,|3327622|gb|AAC41101.1|,|3327610|gb|AAC41096.1|,|3327604|gb| AAC41093.11,|3327598|gb|AAC41090.1 j,|3327592|gb|AAC41087.1|,|3327584|gb|AAC41083.11,|3327624|gb|AAC41102.1|,|3327575|gb|AAC41079.1|,|3327582|gb]AAC41082.1|,|5001981 |gb|AAD37241.11,|5001961|gb|AAD37231.1|,|77167639|gb | AB A62779.11,|77168011|gb|ABA62965.1|,|77167361 |gb|ABA62640.11,|3327672|gb|AAC41126.1|,|3327662|gb|AAC41121.11,|3327646Ígb|AAC41113.1|,|3327636|gb]AAC41108.11,|3327666|gb|AAC41123.1 j,|3327654|gb]AAC41117.1|,|3327644|gb|AAC41112.1|,|3327650|gb|AAC41115.1|,|77167801 |gb|AB A62860.11,|77167487jgb | AB A62703.1 j,|77167625 |gb|AB A62772.11,

]328412|gb|AAA44983.1|57545280|gb|AAW51543.1(77168254|gb]ABA63086.1|7416658|dbj|BAA93969.1|77167363|gb|ABA62641.1|57545278|gb|AAW51542.1|3327628|gb|AAC41104.1|3327618|gb|AAC41099.1|3327608|gb|AAC41095.1|3327602|gb|AAC41092.1|3327596]gb|AAC41089.1|3327590|gb|AAC41086.1|3327577|gb|AAC41080.1]3327614|gb|AAC41098.1|3327586|gb|AAC41084.1|77168229|gb | ABA63074.1|5001971|gb|AAD37236.1|3218158|emb|CAB05083.1|1160037|emb|CAA92872.1|77167643|gb|ABA62781.1|3327676|gb|AAC41128.1|3327668jgb |AAC41124.1|3327656|gb|AAC41118.1|3327642|gbjAAC41111.1|3327634|gb|AAC41107.1j3327630|gbjAAC41105.1Í3327658]gbjAAC41119.1|3327670|gb|AAC41125.1|77167913|gb|ABA62916.1|77167469|gb|ABA62694.1|77167315jgb |AB A62617.1Í77167877|gb|ABA62898.1|77167399[gb[AB Α62659.1j, |77168157|gbjABA63038.1|, |77167619|gb|ABA62769.1|;|77167321 |gb|ABA62620.1|77167415jgb|ABA62667.1|, |139396|sp|P05951|VPR_HV1SC,|328637|gb|AAA45062.1|, |77167937|gb|ABA62928.11, (77167483jgb|ABÁ62701.11,J2393844|gb| AAB70149.I|, |2393826|gb|AAB70l40.1 [, |2393822|gb|AAB70138.1|,|2393820|gb|AAB70l37.1|, |82279707jsp|042071|042071_9, j77168033[gb|ABA6297Ó.1j,

|291 l9269|gb|AA063190,11,[77168404|gb| ABA63161.1|,[77168121Jgb j ABÀ63020» 1 |,|77167971 |gb]ABA62945.1|,177167313|gb|ABA626l6.1 j,177168388jgbfABA63153.11,|1160029|embjCAA92868.1|,|77168045|gb|ABA62982.1|23392765]emb|CAD26720.1][77167965jgb]ABA62942.11,j77167439[gb|ÂB A62679.1],|57545364|gb|AAW51585.11,

|77l67973|gb|ABA62946. Ijsl77167901lgblABA62910.il,[77167849|gb|ABA62884.1[,|77167921jgb|ABA62920.11,Il 160047|emb|CAA92877.1j,|7716818S[gb|ABA63052.1 j,|7416662]dbj|BAA93971.1

J77168246|gb|ABA63082.1 j,|77167475]gb[AB A62697.11,[77168103|gb|ABA63011.1|,|57545308|gb]AAW5155Z1|,(77167681jgb | ABA62800.11,j77168244|gb|ABA63081.1 f,177167503|gb| AB A62711.1 j.

|82295423|sp|Q8AC14|Q8AC14_9>[23392763jembjCAD26719,1 [, |23392761|emb|CAD26718.1|,l77167999lgblABA62959.il, |77167957]gblABA62938.1|,l77167719lgblABA62819.il, |57545346|gb|AAW51576.1],„ |1160025lembjCAA92866.lt, |77168231|gb|ABA63075.1|,177167885|gb| AB A62902.1|77168055|gbJABA62987.110, |77l67555|gb[ABA62737.110,|77167589|gb|ABA62754.1|77167365|gb| AB A62642.1|3 [77167859jgb|ABÀ62889.1|,

J77168376jgb| ABA63147» 1 j,|77167945Jgb | AB A62932.1[77167307|gb | AB A62613.1|3218l42Jemb|CAB05075.1|,

[29119289)gb|AA063208.1 [, _____________________f!

[110959l4|gb[AAG30118.1[AF28, [1 l76378|gtyAAA86733.1|, |77167417|gb|ABA6266S.l|,|77168266|gb|ABA63092.1 j, |77l68344|gb|ABA63131.1], |77168241|gb|ABA63080J|,

[77167951 ]gb|ABA62935.11,|77168017|gb|ABA62968.1[,|77168209[gb]ABA63064.11,|771Ó7397|gbjABA62658.1 j,j77167887|gbj ABA62903.1 |,|77167459]gb[AB A62689,1],[77167673|gb|ABA62796.1|5j74273483jgb j AB AO1463.1 [,174273463[gbjAB AO1445.1

|77l68173|gb|ABA63046.1[,[77168171jgb | AB A63045.1 [,]77167977)gbj AB A62948.11,[77167683[gbjAB A62S01.11,177168113[gb|ABA63016.1|,

j77167575|gb | AB A62747.1 j,|77167579]gb|ABA62749,l|,|77167855|gbjABA62887.1|,]77167349[gb|ABA62634.lj,|57545306]gb|AAW5l556.lj,

|77168109]gb|ABA63014.Í|,|77167835jgb j AB A62877.1|,J77168290fgbjAB A63104.11,|77168043|gb[AB A62981.1[77168077|gb|ABA62998.11,|77167943|gb |AB A62931.1 [,|77168013|gb | AB A62966.11,|77167531jgb j AB A62725.1|,[74273473|gb[ AB AOl454. lj,|7716S15 3 jgbj ABA63036.1j,[82283742|sp|Q66MR2|Q66MR2_9,|82283738|spjQ66MQ4|Q66MQ4_9?182283736|sp|Q66MQ0|Q66MQ0_9,|82283735|sp[Q66MP5|Q66MP5_9

|77168354]gb j AB A63136.1],[77167471jgbj AB A62695. lj,]77167655|gb| ABÀ62787. lj,|77168063[gb[ABA62991.11,[77167359 jgb| AB A62639.1 [,[77168177jgb j AB A63048.11,|77167387|^jjABA62653< 1 [,|74273454]gb] AB AO1437.1|,177168151 jgbf ABA63035.1 [,|57869ó47[gb|AAW57689,1 j,f77l68350|gb[ABA63134.1|,|82283739|sp|Q66MQ6|Q66MQ6_9,[82283741 |sp|Q66MRO|Q66MRO_9>

Proteínas VIF

|1857262|gb[AAB54105.1|,[29409297|gb|AAM67377.1j,117352346]gbJ AALO1565.11,|38491938|gb | AAR22301.1 j,|70633592[gb]AAZ06075.11,

138491783lgbjAAE22162.ll,|38491862|gb|AAR22233.1 [,114290031|gb | AAK59214.1[38491793jgbfAAR22171.1 j,|70633590|gbjAAZ06074.11,

)29409328[gb[AAM67404.1 [,138491853[gb|AAE22225.11,|38491928jgb| AAR22292.1j,|70633594|gb|AAZ06076,1 j,|38491813fgb|AAR22189.1|,|38491803|gb|AAR22180.1|,

|38491918|gb|AAR22283.1|

|57901060|gb|AAW57829.

|7021458|gb|AAF35357.1|,

|83026787|gb|ABB96425.1

|70633660|gb|AAZ06109.1

|70633656|gb|AAZ06107.1

|70633664|gb|AAZ06111.1

|70633466|gb|AAZ06013.1

|70633558|gb|AAZ06058.1

|70633580|gb|AAZ06069.1

|70633572|gb|AAZ06065.1

|70633498|gb|AAZ06028.1

|70633552|gb|AAZ06055.1

|70633528|gb|AAZ06043.1

|70633538|gb|AAZ06048.1

|70633642|gb|AAZ06100.1

|70633616|gb|AAZ06087.1

170633514|gb|AAZ06036.1

|70633476|gb|AAZ06017.1

|70633494|gb|AAZ06026.1

|70633634|gb|AAZ06096.1

|70633636|gb|AAZ06097.1

|70633638|gb|AAZ06098.1

l70633560|gb|AAZ06059.1

|70633672|gb|AAZ06115.1

|70633606|gb|AAZ06082.1

|70633522|gb|AAZ06040.1

|70633462|gb|AAZ06011.1

|70633486|gb|AAZ06022.1

|70633472|gb|AAZ06015.1

|70633544|gb|AAZ06051.1

|70633548|gb|AAZ06053.1

|70633510|gb|AAZ06034.1

|2154663|dbj|B AA20319.1|

|2154657|dbj |B AA20317.1 j

|78172843 |gb|ABB29375.1

|2154671 |dbj |B AA20323.11

|74273413|gb|ABA01400.1

|78172815|gb|ABB29350.1

|70633568|gb|AAZ06063.1

|70905433|gb|AAZ14775.1

|7416538|dbj|BAA93914.1|

|8218028|emb]CAB92788.1

|70633628|gb|AAZ06093.1

|829449|gb|AAA79580.1|,

|829442|gb|AAA79574.1 j,

|2944132|gb|AAC05239.11,

|2570293|gb|AAC32649.1|,|57901100|gb|AAW57865.1|,|5668883|gb | AAD46045.11AF075|83026797|gb|ABB96434.11,|70633670|gb|AAZ06114.11,|70633658|gb|AAZ06108.1|,|70633662|gb|AAZ06110.11,|70633588|gb|AAZ06073.1 j,|70633464|gb|AAZ06012.1|,|70633556|gb|AAZ06057.1 j,l70633578jgblAAZ06068.il,|70633574|gb|AAZ06066.11,|70633502|gb|AAZ06030.1|,|70633550|gb|AAZ06054.1|,|70633526|gb|AAZ06042.1|,|70633602|gb|AAZ06080.1|,|70633604|gb| AAZ06081.1 j,|70633618|gb|AAZ06088.1|,l70633512lgbjAAZ06035.il,|70633474|gb|AAZ06016.1 \,|70633492|gb|AAZ06025.1|,|70633632|gb|AAZ06095.1|,|83026815|gb|ABB96450.1|,|70633564|gb|AAZ06061.1|,|70633644|gb|AAZ06 lOl.lj,|70633610|gb|AAZ06084.1|,|70633622|gb|AAZ06090.1|,|70633520|gb|AAZ06039.11,|70633460|gb|AAZ06010.11,|70633490|gb|AAZ06024.1|,|6580987]gb|AAF18396.1|AF190,|70633542|gb|AAZ06050.1|,|70633508|gb|AAZ06033.1|,|32843 3 |gb|AAB0403 8.11,|2154653 |dbj |B AA20315.11,|2154655|dbj |B AA20316.1 j,11869923 0|gb|AAL78476.1|AF41,|2154667|dbj |B AA20321.11,|74273403|gb| ABAO 1391.1],|70905447|gb|AAZ14782.1|,|70633566|gb|AAZ06062.1|,|70905431 |gb|AAZ14774.11,|57648405|gb|AAW55906.11,]1072089|gb|AAC54545.1|,|70633626|gb|AAZ06092.1|,|829410|gb|AAA79546.1|,|829426|gb|AAA79560.11,|62956363|gb|AAY23499.11,

|1568312|emb|CAA02186.11|38326772|gb|AAR17514.11, |257031 l|gb|AAC97572.1||70633584|gb|AAZ06071.1 j|70633668|gb|AAZ06113.1|62461845|gb|AAX83061.1|70633666|gb|AAZ06112.1||70633586|gb|AAZ06072.1||70633468|gb|AAZ06014.1||70633582|gb|AAZ06070.1|70633576|gb|AAZ06067.1)70633504|gb|AAZ06031.1 j|70633500|gb|AAZ06029.1||70633554|gb|AAZ06056.1]|70633540|gb|AAZ06049.1 j|83026807|gb|ABB96443.1||70633620|gb|AAZ06089.1||70633614|gb|AAZ06086.lj170633516|gb|AAZ06037.1 j|83026777|gb|ABB96416.11|70633496|gb|AAZ06027.11|70633630|gb|AAZ06094.1||70633640|gb|AAZ06099.1||70633562|gb|AAZ06060.1 j|70633674|gb]AAZ06116.11|70633608|gb|AAZ06083.1||70633524|gb|AAZ06041.1||70633518|gb|AAZ0603 8.1 j|70633488|gb|AAZ06023.1||45361201|gb|AAS59392.1|j46254430|gb|AAS86183.1||70633546|gb|AAZ06052.11|70633506|gb|AAZ06032.1||902801 |gb|AAB60573.1 j|2154659|dbj |B AA20318.1 j\2154665jdbj |B AA20320.1111151162|gb|AAA85232.1 j|2154673|dbj|BAA20324.1||74273393|gb|ABA01382.11|70905445|gb|AAZ14781.1||70633570|gb|AAZ06064.1||70905429|gb|AAZ14773.1||7416548|dbj|BAA93919.1||46254406|gb|AAS86165.1||70633624|gb|AAZ06091.11|829418|gb|AAA79553.1||829434|gb|AAA79567.1||62956368|gb|AAY23503.1|73625136|gb|AAZ79333.173625108|gb|AAZ79319.1736251OOjgbj AAZ79315.173625102|gb|AAZ79316.173625092|gb|AAZ79311.173625110|gb|AAZ79320.173625128|gb|AAZ79329.173625106|gb|AAZ79318.173625124|gb|AAZ79327.173625104|gb|AAZ79317.17416584|dbj|BAA93937.174273462|gb|ABA01444.174273374|gb|ABA01366.170905451 |gb| AAZl4784.170633650|gb|AAZ06104.170633446jgb j AAZ06003.170633456|gb|AAZ06008.155275258jgb|AAV49470.155275158|gb|AAV49380.155275238|gb|AAV49452.155275248|gb|AAV49461.155275208|gb|AAV49425.12154628|dbj |B AA20303.12154624|dbj |BAA20301.12154651 jdbj |B AA20314.12154643 jdbj |BAA20310.12154637jdbj |B AA20307.170633478|gb|AAZ06018.11123015 |gb| AAC54644.1170633442|gb|AAZ06001.170633444|gb|AAZ06002.1665535|gb|AAA76687.1|,1398976|dbj|BAA12990.1|,3098575|gb|AAC68843.1|,70633532|gb|AAZ06045.1|,829457|gb|AAA79587.1|,2154683 |dbj |B AA20328.11,829582|gb| AAA79678.1|,829395|gb|AAA79533.1|,829517jgbj AAA79624.1|,829575|gb|AAA79672.1 j,74273443 |gb|AB A01427.11,70905427|gb|AAZ14772.1|,70905421 |gb|AAZ14769.11,70633450|gb|AAZ06005.1 j,70905439|gb|AAZ14778.1|,45686211 |gb|AAS75787.11,70905443 |gb|AAZ14780.11,

|73625126|gb|AAZ79328.11,|73625082|gb|AAZ79306.1|,l73625084lgblAAZ79307.il,|73625090|gb|AAZ79310.11,|73625118|gb|AAZ79324.11,l73625086lgblAAZ79308.ll,|73625088|gb|AAZ79309.1|,|73625122|gb|AAZ79326.11,|73625132|gb|AAZ79331.11,|60195|emb|CAA77623.1|,|74273482|gb|ABA01462.1|,|74273453|gb|ABAO 1436.11,|74273357|gb|ABA01352.1|,|70905449|gb|AAZ14783.1|,|70633646|gb|AAZ06102.1|,|70633454|gb|AAZ06007.11,|55275138|gb|AAV49362.1|,|55275118|gb|AAV49344.1|,|55275148|gb|AAV49371.1|,|55275188|gb|AAV49407.11,|55275228|gb|AAV49443.11,|2154633 |dbj |BAA20305.11,|2154626|dbj |BAA20302.11,l5790108ljgblAAW57848.il,|2154639|dbj |BAA20308.11,|2154647|dbj |BAA20312.11,|2154649|dbj |BAA20313.11,|70633480|gb|AAZ06019.1|,|255648|gb|AAB23296.11,|70633440|gb|AAZ06000.11,|46254438|gb|AAS86189.11,|1398967|dbj|BAA12998.1|,|2801506|gb|AAC82594.11,|70633536|gb|AAZ06047.11,

|70633530|gb|AAZ06044.1|,|2154685|dbj|BAA20329.1|,|2154677|dbj|BAA20326.1|,|829568|gb|AAA79666.1|,|8293 80|gb|AAA79520.11,|829388|gb|AAA79527.1|,|829553|gb|AAA79653.1|,|74273433|gb|ABA01418.1|,|70905423|gb|AAZ14770.1|,|70905419|gb|AAZ14768.11,|70633448|gb| AAZ06004.11,|70905435|gb|AAZ14776.1|,|2154621 |dbj |BAA20300.11,170905441 |gb|AAZ14779.11,

|73625098|gb|AAZ79314.1|73625096|gb|AAZ79313.1|73625130|gb|AAZ79330.1|73625094|gb|AAZ79312.1|73625134|gb|AAZ79332.1|73625120|gb|AAZ79325.1|73625112|gb|AAZ79321.1|73625116|gb|AAZ79323.1173625114|gb|AAZ79322.1|7416592|dbj|BAA93941.1|74273472|gb|AB AO1453.1|74273382|gb|ABA01373.1|74273348|gb|ABA01344.1|57901110|gb|AAW57874.1|70633648|gb|AAZ06103.1|70633452|gb|AAZ06006.1|55275128|gb|AAV49353.1|55275178|gb|AAV49398.1|55275168|gb|AAV49389.1|55275198|gb|AAV49416.1|55275218 |gb|AAV49434.1|2154631 |dbj |B AA20304.1|2154635|dbj|BAA20306.1|57901071|gb|AAW57839.1|2154645|dbj|BAA20311.1|2154641 jdbj |B AA20309.1|70633482|gb|AAZ06020.1 jj70633484|gb|AAZ06021.1|1123005|gb|AAC54635.1||7063343 8 |gb|AAZ05999.1|46254416|gb|AAS86174.1j19629361 |ref]NP_057851.1 j|3098585|gb|AAC68852.1||70633534|gb|AAZ06046.1||829464|gb| AAA79593.11|2154681 |dbj IBAA20327.1 jj2154688|dbj|B AA20330.1||829561 |gb|AAA79660.1 jj829402jgb|AAA79539.1 jj829525jgbÍAAA79631.ljj829545ÍgbjAAA79646.lj|74273423|gb|ABA01409.lj|70905425|gb|AAZ14771.lj|18307192|gb|AAL65581.1|11176377|gb|AAA86732.11|70905437|gb|AAZ14777.lj|2154619|dbj|BAA20299.lj|78172833|gb|ABB29366.1||6580997|gb|AAF18405.1|AF190, |3114567|gb|AAD03185.1|, |311455 8 |gb|AAD03177.11]6090967|gb|AAF03414.1]AF075, |3114550|gb|AAD03170.1|, |14579621|gb|AAK69338.1||16118263|gb|AAL12642.1|, |5668941 |gb|AAD46089.1 |AF077, |14579601 |gb|AAK69320.1 jll457961ljgblAAK69329.il, |16118253|gb|AAL12633.1|, |6636488|gb|AAF20195.1|AF200|5668956|gb|AAD46100.1 |AF076, |6651457|gb|AAF22309.1 |AF193

|38491756|gb|AAR22138.1|, |38491736|gb|AAR22120.1|, |8886634|gb|AAF80533.1|AF179

|38491746|gb|AAR22129.1j, 114290004|gb|AAK59190.11|14290022|gb|AAK59206.11, |6466842|gb|AAFl 3057.11]45361168|gb]AAS59372.1|, )1478059|gb|AAB51138.1 j|38491650|gb|AAR22044.11, |45644383 |gb|AAS72938.1 j|5733944|gb|AAD49782.1 |AF 107, |2570322|gb|AAC97582.11

|38491773|gb|AAR22153.1||38491823|gb|AAR22198.lj|70633458|gb)AAZ06009.1||38491670|gb|AAR22062.1||14289985|gb|AAK59173.1|70633654|gb|AAZ06106.1||38491492|gb|AAR21903.1||38491725|gb| AAR22111.11|38491620jgb j AAR22017.1 jj38491615 |gb jAAR22013.11|38491630jgb j AAR22026.11|38491568|gb|AAR21971.1||38491588|gb|AAR21989.1||38491512jgb j AAR21921.1 jj3849152ljgbÍAAR21929.lj

|70633652|gb|AAZ06105.1|,|45361189|gb|AAS59383.1|,|38491689|gb|AAR22079.1|,Í38491558ÍgbjAAR21962.lj,l38491502lgblAAR21912.ll,Í38491607ÍgbjAAR22006.lj,j38491548jgb j AAR21953.1 j,Í38491538|gbÍAAR21944.1|,j38491764jgbjAAR22145.lj,

|3 8491660|gb| AAR22053.1 j|14289995|gb|AAK59182.1||38491715|gb|AAR22102.1|Í38491697jgbjAAR22086.lj|38491640ÍgbÍAAR22035.1||38491578jgb|AAR21980.1|Í38491705jgbÍAAR22093.lj|38491680|gb|AAR22071.1||38491529|gbÍAAR21936.1||3 808243 jgb| AAC69281.1 j

|3808281 |gb|AAC69307.11,|6636492|gb|AAF20197.1 |AF200, |5305344|gb|AAD41598.1|AP071

|3808273 jgbjAADl 3360.1|, |70633612|gb|AAZ06085.1|, |3808263|gb|AAC69299.1|

|38491882|gb|AAR22251.11, |5733953|gb|AAD49790.1 |AF107|6636490|gb|AAF20196.1 |AF200, |74315771 |gb|ABA02494.11

|3808253 |gb|AAC69290.11,Í45361067|gb|AAS59298.1|74315761 |gb| AB A02485.1|45361149|gb|AAS59361.1j37682960jgbjAAQ98524.1Í37682833jgbjAAQ98413.1j45361115|gbjAAS59334.1Í37682980jgbjAAQ98542.1|37682753|gb|AAQ98341.1Í37682743|gb|AAQ98332.1Í37682723ÍgbjAAQ98314.1|37682713jgb|AAQ98305.1Í37682763jgb|AAQ98350.1Í37682823 |gb j AAQ98404.1j37682803Ígb|AAQ98386.1j37683010jgbjAAQ98569.1|37683039|gb|AAQ98595.1Í38491482jgbjAAR21894.1174315751 |gbjABA02476.1jl4290013jgbjAAK59198.1|18699151|gb|AAL78422.1jl8699136jgbjAAL78409.1178172853 jgb jABB29384.1Í70633596|gbjAAZ06077.1|38491833jgb j AAR22207.1

113560261 |dbj |B AB40912.11,|37683029|gb|AAQ98586.1|,|37682773|gb|AAQ98359.1|,|37682920|gb|AAQ98488.11,|37682881 |gb|AAQ98454.11,|37682891 jgbjAAQ98463.1 j,|14209300|dbj|BAB55909.1|,|1537053|gb|AAC55461.1|,137682703 |gb| AAQ98296.11,Í37682793jgb|AAQ98377.lj,|37682863 jgbj AAQ98440.11,|37682813|gb|AAQ98395.1|,Í37682912jgbjAAQ98481.lj,|37682950|gbjAAQ98515.1|,|45361125|gb|AAS59343.1|,|3403218|gb| AAC29052.11,|74315741 |gb|ABA02467.11,138491901 jgb|AAR22268.11,AF41,AF41,

111993204|gb| AAG42636.11|37683019|gb|AAQ98577.lj|37682853|gb|AAQ98431.1||45361137|gb|AAS59352.11|45361103|gbjAAS59325.1||37682843|gb|AAQ98422.1||37682940|gb|AAQ98506.11|37682990|gbÍAAQ98551.1||37682930|gb|AAQ98497.1|137682783 jgbjAAQ98368.ljÍ37682970jgbjAAQ98533.11j37682733jgbjAAQ98323.1||37683000|gb|AAQ98560.ljj37682902jgbjAAQ98472.1 j|257033 ligb|AAC32658.11|74315781|gb|ABA02503.1||74315734|gb| AB A02461.11|74315724|gb|ABA02452.lj|18699143|gb|AAL78415.1|AF41j 18699133 jgb jAAL78407.1 jAF41

|38491872|gb|AAR22242.11,|70633598|gb|AAZ06078.1|,|3849191 l|gb|AAR22277.1|,

|70633600|gb|AAZ06079.11|38491843|gb|AAR22216.1||6016890|dbjjBAA85227.lj|62956397|gb|AAY23529.1|,|1353863|gb|AAB36502.1|,|4324881|gb|AAD17145.1|,l4324863jgblAAD17127.il,|4324740|gblAADl 7004. lj,|4324809|gb|AAD 17073.1 j,|57901090|gb|AAW57856.1|,|4324784|gb|AAD17048.1|,l4324767jgblAAD17031.ll,|4324912|gbjAAD17176.1|,Í8920154jemb|CAB96340.11,|3287082|emb|CAA75937.1|,|3287159jembjcAA75981.1 j,|3287103 jemb|CAA75941.1 j,Í3287118 jembjcAA75953.1 j,|51599132|gb|AAU08217.1|,Í3287133|emb|CAA75965.1|,|22596340|gb|AAN03120.1|AF45,]41353554|gb|AAS01341.1|,|22596556|gb| AAN03312.1 |AF45,|22596411 |gb|AAN03183.1 |AF45,

|62956388|gb|AAY23521.1|,|2570300|gb|AAC63081.11,|4324890|gb|AAD17154.1|,|4324848|gb|AAD17112.1|,|4324758|gb|AAD17022.1|,|45361077|gb | AAS59307.11,|45361091|gb|AAS59316.1|,|4324793 |gb|AAD 17057.11,|5305356|gb|AAD41608.1|AF071,|4324906|gb|AAD 17170.11,|14041624|emb|CAC38390.1|,|3287164|emb|CAA75985.1|,|3287143|emb|CAA75973.1|,|3287108|emb|CAA75945.1|,|3287113|emb|CAA75949.1|,|51599141 |gb|AAU08225.11,|52421748|gb | AAU453 84.11,

|62956378|gb|AAY23512.1|,|4324899|gb|AAD 17163.11,l4324872jgblAAD17136.il,j4324749jgbjAAD17013.lj,|78172826|gb|ABB29360.lj,|4324833|gb|AAD17097.1|,j4324800jgbjAAD17064.lj,|4324775|gb|AAD 17039.11,l4324918jgblAAD17182.il,|62946403|gb|AAY22380.1|,|3287123 |emb|CAA75957.1|,|3287128|emb|CAA75961.1|,|3287148|emb|CAA75977.11,|45644391|gb|AAS72945.1|,|3287138|emb|CAA75969.1|,|3287077|emb|CAA75933.1|,|52421743|gb|AAU45382.1|,|22596320|gb|AAN03102.1 |AF45,|22596295|gb|AAN03080.1 |AF45,|328907|gb|AAA75020.11,|22596224|gb|AAN03017.1 |AF45,

|13517085 |dbj|BAB40423.11, |25807939|gb|AAN74526.11,|7452901|emb|CAB86367.1|, |7331129|gb|AAF60287.1|AF233,|46405259|gb|AAS93488.11, |459517|emb|CAA83114.11,|4539036|emb|CAB39918.11, |19908409|gb|AAL96764.1|,

|22297042|gb|AAM94498.11,

|82318409|sp|Q6JNH2|Q6JNH2_9, |7188636|gb|AAF37823.1 |AF215,

|28933404|gb|AA062618.1 |AF46, |23394921 |gb|AAN31643.11, |37682542|gb|AAQ98228.11,|37682433|gb|AAQ98130.1|, |39777416|gb|AAR30994.1|, |22596433|gb|AAN03202.1|AF45,

|745291 l|emb|CAB86376.1|,|25807929|gb|AAN74517.11,|4640526 l|gb|AAS93489.1|,|4539049|emb|CAB39739.1|,|23394929|gb|AAN31650.11,

|22596466|gb|AAN03231.1 |AF45,|22596456|gb|AAN03222.1|AP45,|22596330|gb|AAN03111.1 |AF45,|22596486|gb|AAN03249.1|AF45,|22596506|gb|AAN03267.1 |AF45,|22596496|gb| AAN03258.1 |AF45,|22596350|gb|AAN03129.1|AF45,|22596516|gb|AAN03276.1 |AF45,|39777426|gb|AAR31003.1|, |71148570|gb|AAZ28901.1|,|22596390|gb|AAN03165.1 |AF45,|37682522|gb|AAQ98210.11,|22596285jgb j AAN03071.1 |AF45,|22596400|gb|AAN03174.1 |AF45,

|22596566|gb|AAN03321.1 |AF45,|22596380|gb|AAN03156.1|AF45,|22596264|gb|AAN03053.1 |AF45,|22596536|gb|AAN03294.1|AF45,|39777436|gb|AAR31012.11,|37682443 |gb | AAQ98139.11,|39777386|gb|AAR30967.1|, |39777376|gb|AAR30958.1|,|22596546|gb|AAN03303.1|AF45,|22596274|gb|AAN03062.1 |AF45,|22596370|gb|AAN03147.1 |AF45,|22596421 |gb|AAN03192.1 |AF45,|22596476|gb|AAN03240.1|AF45,|22596244|gb| AAN0303 5.1 j AF45,|22596360|gb|AAN03138.1|AF45,

|22596446|gb|AAN03213.1 |AF45,|37682532|gb|AAQ98219.11, |22596234|gb|AAN03026.1|AF45, |66473532|gb|AAY46412.1|,|46405339|gb|AAS93528.11, |46405341 |gb|AAS93529.11, |7331131 |gb|AAF60288.1 |AF233,|29119326|gb|AA063241.1|, |29119317|gb|AA063233.1|, |16118376|gb|AAL12741.1|,|45360180|gb|AAS59214.1|, |16118396|gb|AAL12759.1|, |16118342|gb|AAL12711.1|,|16118330|gb|AAL12701.1|, |16118303|gb|AAL12678.1|, |45360170|gb|AAS59205.1|,|16118313|gb|AAL12687.1|,|16118366|gb|AAL12732.1|,|45360191 |gb|AAS59224.11,|57648397|gb|AAW55902.11,|57648403|gb|AAW55905.11,|57648387|gb|AAW55897.1|,|459455|emb|CAA83082.1|,|7416536|dbj|BAA93913.1|,|7416572|ά^|ΒΑΑ93931.1|,|7416580|dbj|BAA93935.1|,|459624|emb|CAA83173.11,|49472924|gb|AAT66269.1|,146405301 |gb|AAS93509.1|,|24753955|gb|AAN64082.1|,|459449|emb|CAA83079.1|,|459507|emb|CAA83109.1 j,|459485|emb|CAA83098.1 j,|459481 |emb|CAA83096.1|,|29119268|gb|AA063189.11,|459483|emb|CAA83097.11,|459463|emb|CAA83086.1|,|459487|emb|CAA83099.1 j,|49472942|gb|AAT66285.1|,|23392823 |emb|CAD26951.11,|23392835|emb|CAD26957.1|,|459596|emb|CAA83159.1],|459469|emb|CAA83090.1|,|23392847|emb|CAD26963.1|,

|45360150|gb|AAS59187.1|,|16118352|gb|AAL12720.1|,|71726044|gb|AAZ39172.1|,|57648395|gb|AAW55901.11,|57648391|gb|AAW55899.1|,|57648399|gb|AAW55903.1|,|7416542|dbj |B AA93916.11,|82308945|sp|042061|042061_9,

|7416576|dbj|BAA93933.1|,|82309077|sp|057303|057303_9,|459620|emb|CAA83171.1|,|16118293|gb|AAL12669.1|,|46405299|gb|AAS93508.1|,|46405255|gb|AAS93486.11,|459527|emb|CAA83119.1|,|459459|emb|CAA83084.1|,|459513|emb|CAA83112.1|,|3002842|gb|AAD03201.11,|459465|emb|CAA83088.11,|459632|emb|CAA83133.11,|459479|emb|CAA83095.1|,|459525 |emb|CAA83118.1],]459447|emb|CAA83078.11,

|459497|emb|CAA83104.11,|23392833 |emb|CAD26956.11,|459521 ]emb|CAA83116.11,|29119298|gb|AA063216.1|,

|45360140|gb|AAS59178.1||45360211|gb|AAS59242.1||16118338|gb|AAL12708.1||57648393 |gb|AAW55900.11|57648389|gb|AAW55898.l!|459626|emb|CAA83174.11]7416540|dbj |B AA93915.1]|7416578|dbj|BAA93934.1|7416574|dbj|BAA93932.1|56417608|gb|AAV90746.1|16118386|gb|AAL12750.1|29119258|gb|AA063180.1|24753963|gb|AAN64088.1||46405253|gb|AAS93485.1||16118273|gb|AAL12651.1||459493 |emb|CAA83102.11|29119344|gb|AA063257.1||459473|emb|CAA83092.11|1171167|gb|AAA86248.1||459539|emb|CAA83085.11|459489|emb|CAA83100.1||459622|emb|CAA83172.1]]23392825|emb|CAD26952.11{29119288|gb|AA063207.11|23392837|emb|CAD26958.1||3378124|gb|AAC28447.1 j|23392849|emb|CAD26964.1||23392845|emb|CAD26962.1 j

|82312473|sp|Q8ACOO]Q8ACOO_9, |11177289|gb|AAG32214.1|, |11177263|gb|AAG32201.1|111177269|gb| AAG32204.11, 111177277|gb| AAG32208.11, 111177228|gb]AAG32185.1 j

|11177275|gb|AAG32207.1|,|11177251 jgbj AAG32195.1|,|11177232|gb|AAG32186.1|,111177234jgbj AAG32187.11,jlll77238jgb|AAG32189.lj,jlll77224jgbjAAG32183.il,111177261 |gb|AAG32200.11,|11177285|gb|AAG32212.1|,|11177259|gb|AAG32199.1|,|7416634]dbj ]BAA93962.11,|7416546|dbj|BAA93918.1|,|459495|emb]CAA83103.1|,|11177307|gb|AAG32223.1|,|11177291 |gb|AAG32215.1|,111177305 |gb| AAG32222.11,111177293 |gb| AAG32216.11,|48686726|gb|AAS93520.2|,|46405305|gb|AAS93511.11,

|11177273|gb|AAG32206.11,|11177249|gb|AAG32194.1|,111177247|gb|AAG32193.1 j,|11177253|gb|AAG32196.1|,|11177245|gb|AAG32192.1|,]11177257|gb|AAG32198.1|,j 11177226jgb j AAG32184.11,|11177281|gb|AAG32210.1|,|11177271|gb|AAG32205.1|,|7416632|dbj|B AA93961.il,|7416544|dbj|BAA93917.1|,|11177315|gb|AAG32227.1|,111177299|gb| AAG32219.11,|11177301 |gb| AAG32220.1|,111177303|gb| AAG32221.11,111177313|gb|AAG32226.11,|46405325|gb|AAS93521.1|,|46405303|gb|AAS93510.1|,

|11177255|gb|AAG32197.1||11177240|gb|AAG32190.1||11177236|gb|AAG32188.1||11177242|gb|AAG32191.1||11177265|gb|AAG32202.11[11177283 |gb|AAG32211.1 jjl 1177267|gb|AAG32203.11|11177279|gb|AAG32209.11|11177287|gb|AAG32213.11|7416630|dbj|BAA93960.1||3002832|gb|AAD03192.1 j111177311 |gb|AAG32225.11111177295 |gb|AAG32217.11jl 1177309|gb|AAG32224.1 j|11177297|gb|AAG32218.1||48762715|gb|AAS93515.2||46405365|gb|AAS93541.1 j|46405265|gb|AAS93491.1||46405263|gb|AAS93490.11,l46405315lgblAAS93516.ll,|46405355|gb|AAS93536.1|,|46405275|gb|AAS93496.1|,|46405319|gb|AAS93518.1|,|46405247|gb|AAS93482.1 j,|46405173|gb|AAS93446.1|,|46405245|gb|AAS93481.1 j,|46405165|gb|AAS93442.1|,|46405205|gb|AAS93462.1|,|46405161 |gb|AAS93440.1|,|46405169|gb|AAS93444.1|,|46405251 |gb|AAS93484.1|,|46405199|gb|AAS93459.1 j,|46405237|gb|AAS93477.1|,|46405229|gb|AAS93474.1|,|46405221 |gb|AAS93470.1 j,|46405279|gb|AAS93498.1],|46405211 |gb|AAS93465.11,|46405235|gb|AAS93476.1|,|46405343|gb|AAS93530.1 j,|46405187|gb|AAS93453.1 j,|46405271 |gb|AAS93494.1 j,|46405337|gb|AAS93527.1 |,|46405331 |gb|AAS93524.11,l46405295lgblAAS93506.ll,|46405287|gb|AAS93502.1|,|4640518 l|gb|AAS93450.1|,|71725984|gb|AAZ39118.1|,|71726014|gb|AAZ39145.1|,|459602]emb|CAA83162.1],|23392829|emb|CAD26954.11,|23396014|emb|CAD27178.1|,|23392855 |emb|CAD26967.11,|459610|emb|CAA83166.1|,|7416616|dbj|B AA93953.1|,|7416560|dbj|BAA93925.1|,|1465780|gb|AAB05600.1|,|46405257|gb|AAS93487.1|,|459614|emb|CAA83168.1|,|7416586|dbj|BAA93938.1|,|459606|emb|CAA83164.11,|16118283|gb|AAL12660.1|,|71725954|gb|AAZ39091.1|,|49472951 |gb|AAT66293.1 j,|7416622|dbj|BAA93956.1|,|7416594|dbj |BAA93942.11,|7416564|dbj|BAA93927.1|,

|46405311 |gb|AAS93514.11,|46405269|gb|AAS93493.1|,|46405351 |gb|AAS93534.1 j,|46405273|gb|AAS93495.11,)46405309]gb|AAS93513.1|,|46405175|gb|AAS93447.11,|46405243 |gb|AAS93480.1 j,|46405209|gb|AAS93464.1|,|46405195|gb|AAS93457.11,|46405203jgb j AAS93461.11,|46405217|gb|AAS93468.1 j,|46405167|gb|AAS93443.1|,|46405232|gb|AAS93475.1|,|46405197|gb|AAS9345 8.11,|46405225|gb|AAS93472.1|,|46405227|gb|AAS93473.11,|46405219|gb|AAS93469.1|,|46405277|gb|AAS93497.11,|46405329|gb|AAS93523.1|,|46405349|gb|AAS93533.1|,|46405345|gb|AAS93 531.1 j,|46405189|gb|AAS93454.11,|46405359|gb|AAS93538.1|,|4640533 5 |gb| AAS93 526.1 j,|46405297|gb|AAS93507.1|,|46405291 |gb|AAS93504.11,|46405285]gb|AAS93501.1|,|46405179|gb|AAS93449.11,|71725974|gb|AAZ39109.1|,|71726004|gb|AAZ39136.1|,]459600|emb|CAA83161.11,|23392827|emb|CAD26953.11,|23392853 |emb|CAD26966.11,|29119340|gb|AA063254.11,|7416620|dbj|B AA93955.il,|7416614|dbj |B AA93952.11,|7416558|dbj |B AA93924.11,|45950l|emb|CAA83106.1|,|459505|emb|CAA83108.11,|45947l|emb|CAA83091.1|,|7416582|dbj|BAA93936.1|,|459475|emb|CAA83093.1|,|71725994|gb|AAZ39127.1|,|45360201|gb|AAS59233.1|,|459467|emb|CAA83089.1|,|7416624|dbj|BAA93957.1|,|7416590|dbj|BAA93940.1|,|7416568 jdbj |B AA93 929.1 j,

|46405317|gb|AAS93517.1|46405267|gb|AAS93492.1|46405353|gb|AAS93535.1|4640532l|gb|AAS93 519.1|46405307|gb|AAS93512.1|46405171|gb|AAS93445.1146405241 |gb|AAS93479.1|46405207|gb|AAS93463.1|46405193|gb|AAS93456.1|46405163|gb|AAS93441.1|46405215|gb| AAS93467.1|48686723 |gb|AAS93483.2|46405183 |gb|AAS93451.1146405201 |gb|AAS93460.1|46405223|gb|AAS93471.1|46405239|gb|AAS93478.1|4640528 l|gb|AAS93499.1|46405213jgb| AAS93466.1|46405327|gb|AAS93522.1|46405347|gb|AAS93532.1|46405191 |gb| AAS93455.1|46405185 |gb|AAS93452.1|46405357|gb|AAS93537.1|46405333|gb|AAS93525.1|46405293 |gb|AAS93505.1|46405289|gb|AAS93503.1|46405283|gb|AAS93500.1|46405177|gb|AAS93448.1|71726024|gb|AAZ39154.1|17981621|gb|AAL51091.1|459604|emb|CAA83163.1|23392831 |emb|CAD26955.1|23392851|emb|CAD26965.1|459519|emb|CAA83115.1|7416618|dbj|BAA93954.1|7416612|dbj|BAA93951.1|459509|emb|CÀA83110.1|459499|emb|CAA83105.1|459616|emb|CAA83169.1|7416588|dbj|BAA93939.1|459491|emb|CAA83101.1|71726034|gb|AAZ39163.1|71725964|gb|AAZ39100.1|45360160|gb|AAS59196.1|7416626|dbj|BAA93958.1|7416628|dbj|BAA93959.1|7416570|dbj|BAA93930.1|7416566|dbj|BAA93928.17416562|dbj|BAA93926.1|,7416556|dbj|BAA93923.1|,459457|emb|CAA83083.11,459630|emb|CAA83176.1 j,46405363 |gb|AAS93540.1|,11177209|gb|AAG32182.1|,11177188|gb|AAG32172.1|,11177190|gb|AAG32173.1|,11177182|gb|AAG32169.1|,11177196|gb|AAG32176.1|,29119307|gb|AA063224.1|,24753996|gb|AAN64115.1|,7416598|dbj|BAA93944.1|,459608|emb|CAA83165.1|,459503|emb|CAA83107.1|,459477|emb|CAA83094.1|,23392839|emb|CAD26959.1|,7416608|dbj |BAA93949.11,

|7416554|dbj |BAA93922.11,|7416550|dbj|B AA93920.il,|459511 |emb|CAA83111.11,|818217|gb|AAB47929.1|,|46405361|gb|AAS93539.1|,|11177184|gb|AAG32170.1|,|11177206|gb|AAG32181.1|,|11177198|gb|AAG32177.1|,|11177200|gb|AAG32178.1|,

|7416552|dbj|BAA93921.1|459618|emb|CAA83170.1|45945 l|emb|CAA83080.1|459612|emb|CAA83167.1|459598|emb|CAA83160.1111177204|gb|AAG32180.1111177202|gb|AAG32179.1|11177186|gb|AAG32171.1|11177194|gb|AAG32175.1

111177192|gb|AAG32174.11, |82309078|sp|057309|057309_9|24753985|gb|AAN64106.1|, |24753974|gb|AAN64097.1

|24754006|gb|AAN64124.11,|7416596|dbj|B AA93943.1|,|459523 |emb|CAA83117.11,|459628 |emb|CAA83175.11,|459453|emb|CAA83081.1|,|23392841 |emb|CAD26960.1|,|7416604|dbj |B AA93947.11,

|29119278|gb|AA063198.1|7416600|dbj|BAA93945.1|459515|emb|CAA83113.1|459461 |emb|CAA83087.1|23392843 |emb|CAD26961.1|7416610|dbj|BAA93950.1|7416602|dbj|BAA93946.1

7416606|dbj|BAA93948.11, |25166993|gb|AAN73765.1|AF48, |37682492|gb|AAQ98183.125166743 |gb|AAN73540.1|AF48, |22596576|gb|AAN03330.1|AF45

39777396|gb|AAR30976.1|,

73913776|gb|AAZ91759.1|,

73913894|gb|AAZ91865.1|,

73913933|gb|AAZ91900.1|,

82571252|gb|ABB84025.11,

73913786|gb|AAZ91768.1|,

82571301|gb|ABB84069.1|,

3252929|gb|AAD12080.1|,

82571222|gb|ABB83998.1|,

73913855|gb|AAZ91830.1|,

82571193|gb| ABB83972.11,

|39777406|gb|AAR30985.1|,

|37682601 |gb| AAQ98281.11,

|82571381|gb|ABB84141.1|,

|82571242|gb|ABB84016.1|,

|73913796|gb|AAZ91777.1|,

|32261506|gb|AAP76566.1|,

|73913806|gb|AAZ91786.1|,

|3252939|gb|AAD12089.1|,

|73913875|gb|AAZ91848.1|,

|73913815|gb|AAZ91794.1|,

|8257131 l|gb|ABB84078.1|82571232|gb|ABB84007.1|82571398|gb|ABB84156.1|73913967|gb|AAZ91930.1|82571331 |gb|ABB84096.1|82571213|gb|ABB83990.1|3252969|gb|AAD12116.1|82571321|gb|ABB84087.1|73913825|gb|AAZ91803.1|82571203|gb|ABB83981.1|73913923|gb|AAZ91891.1

|82571291 |gb|ABB84060.1|,82571408|gb|ABB84165.1|, |82318458|sp|Q98VH0|Q98VH0_9, |32261467|gb|AAP76531.137682591 |gb|AAQ98272.1|, |37682552|gb|AAQ98237.11, |82571361 |gb|ABB84123.1

|8257128 l|gb|ABB84051.1|,|22596254|gb|AAN03044.1 (AF45,

|73913995|gb|AAZ91955.1|,|22596526|gb|AAN03285.1|AF45,|37682473|gb|AAQ98166.1],|32261487|gb|AAP76549.1|,22596310|gb|AAN03093.1|AF45, |37682412|gb|AAQ98111.1|,82571262|gb|ABB84034.1|, |73913835|gb|AAZ91812.1|,32261477|gb|AAP76540.11, |73913845|gb|AAZ91821.11,37682453|gb|AAQ98148.1|, |37682423|gb|AAQ98121.1|,37682581 |gb| AAQ98263.11, |37682571 |gb|AAQ98254.11,5305569|gb|AAD41704.1|AF097,5305577|gb|AAD41711.1|AF097,

8257135ljgb|ABB84114.1|,73913865|gb|AAZ91839.1|,8257137 l|gb|ABB84132.1 j,32261497|gb|AAP76558.1|,63081179|gb|AAY30341.1|,37682463|gb|AAQ98157.11,

Í8257134ljgbjABB84105.1|73913904|gb|AAZ91874.1|37682483|gb|AAQ98175.1|2194189|gb|AAB61127.1|37682512|gb|AAQ982Ól.l|32261458|gb|AAP76523.1|82571271|gb|ABB84042.1|37682502|gb|AAQ98192.1|73913914|gb|AAZ91883.1|73913977|gb|AAZ91939.1|37682562|gb|AAQ98246.1|5305561 |gb|AAD41697.1 |AF097|14041638|emb|CAC3 8422.1

14041628|emb|C AC3 8431.11,37935892|gb|AA047139.1|,

|37935971 |gb|AA047209.11,|37935872|gb|AA047122.1|,

|37935901|gb|AA047147.1|37935852|gb|AA047104.1|37935842|gb|AA047095.1|,|37935952|gb |AA047192.1 j,137935981 |gb|AA047218.1 j,|37935862|gb|AA047113.1|,|46243166|gb|AAS83692.11,|6643028|gb|AAF20389.11,|9368381|emb|CAB98170.1|,|29409309|gb|AAM67388.11,

|37935912|gb|AA047156.1|,|37935922|gb|AA047165.1|,|37935881 |gb|AA047130.1|,141223201 |emb|CAD92650.1|,|46243156|gb|AAS83683.1|,|37496492|emb|CAD48449.1|,|3779263 |gb|AAD03311.11,

|37935932|gb|AA047174.1137935961 |gb|AA047200.1|37935942|gb|AA047183.1|47027390|gb|AAT08770.1|9368371 |emb|CAB98188.1|5738568|emb|CAB53044.1129409316|gb|AAM67394.1|71794577|emb|CAI28819.1

|22532133|gb|AAM97845.1 |AF46, |38679143|gb|AAR26397.1|, |38679134|gb|AAR26389.1|24181480|gb|AAN47102.1|, |4336341|gb|AAD17767.1|, |4336332|gb|AAD17758.1|5019906|gb|AAD37900.1|, |5019878|gb|AAD37872.1|,|5019905|gb|AAD37899.1|, |5019898|gb|AAD37892.1|,|11095913|gb|AAG30117.1|AF28, |3694863|gb|AAC62477.1|,l5786957ljgblAAW57621.il, |5019890|gb|AAD37884.1|,|5019871 |gb|AAD37865.1|, |5019870|gb|AAD37864.11,|2286127|gb|AAB64274.1|, |15407026|gb|AAG41567.1|,

|32261283 |gb|AAP74182.11,|5019919|gb|AAD37913.1|,|5019910|gb|AAD37904.11, |6910970|gb|AAF31321.1 |AF146|5019904|gb|AAD37898.11, |5019912|gb|AAD37906.1|5019914|gb|AAD37908.1|,|5019S88|gb|AAD37882.1|,l5019913lgblAAD37907.ll,|5019907|gb|AAD37901.1|5|40021825 |gb| AAR37153.11,|40021765 jgbj AAR3 7111.1 j,|40021865|gb|AAR37181.1|,|40021695|gb|AAR37062.11,|40021855 |gb|AAR37174.1 j,|40021835 jgb |AAR37160.1 j,|5019889|gb|AAD37883.1|,|5019873|gb|AAD37867.1|,|5019901 |gb|AAD37895.1|,l5019918lgblAAD37912.ll,|5019876|gb|AAD37870.1|, |6651482|gb|AAF22330.1|AF193]6651475|gb|AAF22323.1 |AF193, |5019872|gb| AAD37866.11, |3002870|gb|AAD03226.1 j|5019909|gb|AAD37903.1|, |5019899|gb|AAD37893.1|, |5019893|gb|AAD37887.1||5019896|gb|AAD37890.1|, |5019881|gb|AAD37875.1|, |5019874|gb|AAD37868.1||5019884|gb|AAD37878.1|, |57869581|gb|AAW57630.1|, |3002888|gb|AAD03242.1||3002852jgbj AAD03210.1 j, j3002861 |gb| AAD03218.11, |57869562|gb|AAW57613.11jl4269049|gb|AAK58006.1|AJF36, |31559692|dbj|BAC77513.1|, |11761312|dbj|BAB19247.1|

|15407021|gb|AAG41565.1|,

|32261262|gb|AAP74163.1|,

Í5019877|gb|AAD37871.11,

Í5019916jgb|AAD37910.lj,

|5019883|gbjAAD37877.1|,

|5019897jgbjAAD37891.lj,

Í5019917|gb|AAD37911.1|,

j5019892jgbjAAD37886.1|,

|40021885|gb|AAR37195.1|

|40021775jgb jAAR37118.1 j

Í40021715|gbjAAR37076.1 j

j40021795jgb | AAR37132.1 j

|40021755 jgbjAAR37104.11

j40021745jgb|AAR37097.11

|40021875|gbjAAR37188.1|

j5019895|gb|AAD37889.1|,

Í5019886|gb|AAD37880.1|,

Í5019880jgbjAAD37874.1 j,

Í501991ljgbjAAD37905.lj,

|57869600|gb|AAW57647.1|30027256|gb|AAP06259.1|3002879|gb|AAD03234.1|5019875|gb|AAD37869.1|2286136|gb|AAB64282.1115407024|gb|AAG41566.1|32261272|gb|AAP74172.1]5019915|gb|AAD37909.1

j5019900jgbjAAD37894.1|5019891|gb|AAD37885.1|5019894|gb|AAD37888.1|5019903|gb|AAD37897.1|40021805|gb|AAR37139.1|40021735|gb|AAR37090.1|40021725|gb|AAR37083.1|40021845 |gb|AAR37167.1|40021705|gb |AAR37069.1|40021815|gb|AAR37146.1|5019882|gb|AAD37876.1|5019887|gb|AAD37881.1|5019902|gb|AAD37896.1|5019879|gb|AAD37873.1

|11761305|dbj|BAB19241.1|,|31559664|dbj|BAC77488.1|,|55925129|gb|ÀAV67934.11,|55925137|gb|AAV67941.1|,|15407134|gb|AAG41569.1|,|19072106|dbj|B AB85753.1|,|55740238|gb|AAV63811.1|,

|26518639|gb|AAN83913.1|,|34811836|gb|AA040779.11,|55925121 |gb|AAV67927.11,|15407136|gb|AAG41570.1|,132189801 |gb|AAP75712.1|,|55740248|gb|AAV63820.1|,

|31559616|dbj |BAC77445.11|5019908|gb|AAD37902.1|155925113|gb|AAV67920.1||15407132|gb|AAG41568.1||30038316|gb|AAP12629.1||55740228|gb|AAV63802.1||18074001|emb|CAC86566.1||25 l66893|gb|AAN73675.1 |AF48, |5668913|gb|AAD46067.1 |AF076,

|17902150|gb|AAL47813.1|, |17864053|gb|AAL47046.1|, |17902128|gb|AAL47795.1|,|17902117|gb|AAL47786.1|, jl7902106|gb|AAL47777.1|, |17864033|gb|AAL47028.1|,|17902139|gb|AAL47804.1|, |17902095|gb|AAL47768.1|, |17864043|gb|AAL47037.1|,|62361771|gb|AAX81419.1|, |71794625|emb|CAI28864.1|, |71794615|emb|CAI28855.lj,171794606jemb |C AI28846.11, |71794597|emb|CAI28837.1|, |37496484|emb|CAD48442.1|,|7321146|emb|CAB82228.1|, |7321136|emb|CAB82219.1|, |25166641|gb|AAN73449.1|AF48,138679151 |gb|AAR26404.11, |25166943|gb|AAN73720.1 |AF48,

115281442jgb|AAK94230.1 |AF36, |57869544|gb|AAW57597.11,

115281432|gb|AAK94221.1 |AF36, |31980438|dbj|BAC77757.1|, |31980428|dbj|BAC77748.1|,|25166923 |gb|AAN73702.1 |AF48, |25166973|gb|AAN73747.1|AF48,

|25166681 |gb|AAN73485.1 |AF48, |31980418|dbj|BAC77739.1|, |31980408|dbj|BAC77730.1|,|25166783|gb|AAN73576.1|AF48J |25166763|gb|AAN73558.1|AF48,

|7657891|emb|CAB89145.1|, |33390881|gb|AAQ17100.1|, |1732477|gb|AAB38825.1|,13676491 |gb|AAC61995.11, |62467713|gb|AAX83967.11, |62467704|gb|AAX83959.11,|15982650|gb|AAL09938.1|, |56609329|gb|AAW03281.1|, |56609263|gb|AAW03222.1|,|56609243|gb|AAW03204.1|, |56609303|gb|AAW03258.1|, |56609323|gb|AAW03276.1|,|56609293|gb|AAW03249.1|56609273|gb|AAW03231.1|, |56609313|gb|AAW03267.1|,]25166883|gb|AAN73666.1|AF48J |33331477|gb|AAQ10921.1|, |33331457|gb|AAQ10903.1|,|33331467|gb|AAQ10912.1|, |37496500|emb|CAD48456.1|,

|25166863|gb|AAN73648.1|AF48, |57869722|gb|AAW57756.1|, |1732487|gb|AAB38834.1|,111066500|gb|AAG28615.1 |AF25, 111066490|gb|AAG28606.1 |AF25,

|7715904|gb|AAF68194.11, |7715899|gb|AAF68190.11, |7715894|gb|AAF68186.11,|7715887|gb|AAF68181.11, |7715891 |gb|AAP68184.11, |33328322|gb|AAQ09611.11,|57869686|gb|AAW57724.1|, |18844739|dbj|BAB85461.1|, |18844729|dbj|BAB85452.1|,|33328200|gb|AAQ09548.11, |57869676|gb|AAW57715.11, |57869695|gb|AAW57732.11,|57869713|gb|AAW57748.1|, |23194121|gb|AAN15029.1|, |57869704|gb|AAW57740.11,|31559682|dbj |B AC77504.11, |33328190|gb|AAQ09539.1|, |31559634|dbj |BAC77461.1 j,|57869666|gb|AAW57706.1 j, |57869731|gb|AAW57764.1|,

j 14530265|gb|AAK65995.1 |AF31, |56609340|gb|AAW03290.1 j,

l56609253jgbjAAW03213.il, j56609283jgb|AAW03240.lj,

jl4530247jgbjAAK65979.1|AF28, |14530239|gb|AAK65972.1|AF28,

jl4530256jgbjAAK65987.1|AF28, |14530229|gb|AAK65963.1|AF28,

|51950722|gb|AAUl 4914.1 j, |51950712|gb|AAU14905.1|, |71794587|emb|CAI28828.1|,118073403jemb|CAC87994.11, 115209254|emb|CAC51033.1], 118073413|emb|CAC88003.1 j,|22532294|gb|AAM97887.1|AF49, |22532284|gb|AAM97878.1|AF49,

159003610|gb|AAW83611.11, 112957276|gb|AAK09121.1 |AF32, |38892700|gb|AAR27699.11,|73913756|gb|AAZ91741.1|, |55139310|gb|AAV41328.1|, |67553053|gb|AAY68644.1|,158220991 |gb|AAW68170.1|, |63098335|gb|AAY32383.1|, |12957270|gb|AAK09116.1|AF32,112957264|gb|AAK09111.1 |AF32, |63098432|gb|AAY32470.11, |37935583|gb|AA065556.11,|37909404|gb|AA065565.1|, |58220962|gb|AAW68144.1|, |12957324|gb|AAK09161.1|AF32,|63098307|gb|AAY32358.1|, |11321030|gb|AAG34021.1|, |11321010|gb|AAG34003.1|,lll321020jgbjAAG34012.il, |11321000|gb|AAG33994.1|, |13569290|gb|AAK31028.1|AF28,|58220942|gb|AAW68126.1|, |67552978|gb|AAY68577.1|, ]67552988|gb|AAY68586.1|,|38892647jgbjAAR27652.1|, |51572106|gb|AAU06755.1|, |58220922|gb|AAW68108.lj,118643012jgb j AAL74047.11, |38892738|gb|AAR27733.1|, |68522036|gb|AAY98633.1|,|46486629|gb|AAS98736.1|, |12957294|gb|AAK09136.1|AF32,

|12957282jgbjAAK09126.1|AP32, |55139273|gb|AAV41295.1|, |73913766|gb|AAZ91750.1|,]67553016|gb|AAY68611.11,|58220892|gb|AAW68081.1|58221029|gb|AAW68204.1|38892756|gb|AAR27749.1|58220872|gb|AAW68063.1|59003620|gb|AAW83620.1|68522086|gb|AAY98678.1|68521996|gb|AAY98597.1|63098412|gb|AAY32452.1|38892718|gb|AAR27715.1112957336|gb|AAK09171.1|55139351 jgb|AAV41364.1|13569320|gb|AAK31055.1|58220862|gb|AAW68054.1|,113569220|gb|AAK30965.1|12957288|gb|AAK09131.1|58220972|gb|AAW68153.1|59003590|gb|AAW83593.1|68521966|gb |AAY98570.1|13569210|gb|AAK30956.1113569270|gb|AAK31010.1|13569240|gb|AAK30983.1|11761285|dbj|BAB19224.1|11761275|dbj|BAB19216.1|31559626|dbj|BAC77454.1113 5 69300|gb|AAK31037.1|23986237|gb|AAL12193.1|63098364|gb|AAY32409.1|63098297|gb|AAY32349.1|59003629|gb|AAW83628.1|55139281 |gb|AAV41302.1|63098373|gb|AAY32417.1112957366|gb|AAK09196.1|58221039|gb|AAW68213.1|38892638|gb|AAR27644.1|63098354|gb|AAY32400.1|68521936|gb|AAY98543.1|38892775|gb|AAR27766.1|26000256|gb|AAN75291.1|68522126|gb|AAY98714.1]57869637|gb|AAW57680.1|68522076|gb|AAY98669.1|15281452|gb|AAK94239.1|12957318|gb|AAK09156.1|12957354|gb|AAK09186.1|68522046|gb|AAY98642.1113 569260|gb|AAK31001.1|13569230|gb|AAK30974.1

|51572096|gb|AAU06746.11|59003510|gb|AAW83521.1||3 8892691 |gb|AAR27691.11|63098422|gb|AAY32461.1||68522146|gb|AAY98732.1||3 8892656|gb|AAR27660.1 j|3 8892601 |gb|AAR27611.11|58220912|gb|AAW68099.1||55139263|gb|AAV41286.lj|59003570|gb|AAW83575.1|

|63098325|gb|AAY32374.1|,|59003649|gb|AAW83646.1|,|63098392|gb)AAY32434.1|,|67553024|gb|AAY68618.11,|57869627|gb|AAW57671.1|,|38892682|gb|AAR27683.11,|67552998|gb|AAY68595.1|,|67553103 |gb|AAY68689.11,|55139331|gb|AAV41346.1|,|58220882|gb|AAW68072.1|,AF32, |12957330|gb|AAK09166.1|AF32

|59003560|gb|AAW83566.1|, |58220932|gb|AAW68117.1|AF28, |38892728|gb|AAR27724.1|, |68521956|gb|AAY98561.1||68522006|gb|AAY98606.11, |24181490|gb| AAN47111.11AF28, |38892664|gb|AAR27667.1|, |55139254|gb|AAV41278.1|AF32, |68521986|gb|AAY98588.1|, |67553083|gb|AAY68671.1|

|15281501|gb|AAK94283.1|AF36|59003530|gb|AAW83539.11, |68522016|gb|AAY98615.11

|15281472|gb|AAK94257.1|AF36AF28, |57869619|gb|AAW57664.11

AF28, |13569280|gb|AAK31019.1|AF28

AF28, |30269368|gb|AAP29646.11, |31559644|dbj|BAC77470.1|111761282|dbj |B AB19222.11,|31559672|dbj |B AC77495.1 j,|11761268|dbj|B AB19210.1|,AF28, |23986253|gb|AAL12202.1|,|23986223|gb|AAL12184.1|,|68522096|gb|AAY98687.1|, |15281491|gb|AAK94274.1|AF36|13569250|gb|AAK30992.1|AF28, |58221019|gb|AAW68195.1||32344838|gb|AAM82294.11, |16751251 |gb|AAL05327.1 j|3 8892621 |gb| AAR27629.11, |38892611|gb|AAR27620.1||59003540|gb|AAW83548.1|, |12957372|gb|AAK09201.1|AF32AF32, |46486648|gb|AAS98753.11, |24181500|gb|AAN47120.1|16751261|gb|AAL05336.1|,|38892628|gb|AAR27635.11,|68522066|gb|AAY98660.11,|46486656|gb|AAS98760.1|,|55139342|gb|AAY41356.1|,

jll761298jdbjjBAB19235.1||31559654|dbj|BAC77479.11|30720409|gb|AAP33677.11|23986209|gb|AAL12175.1||58220902|gb|AAW68090.1 j

|38892784|gb|AAR27774.|38892765|gb|AAR27757.1||58220952|gb|AAW68135.1||16751241|gb|AAL05318.1||59003600|gb|AAW83602.1|

112957246|gb|AAK09096.1 |AF32, [51572115|gb|AAU06763.11|63098345|gb|AAY32392.1|, |51572125|gb|AAU06772.1||68522116|gb|AAY98705.11, 113569330|gb|AAK31064.1 |AF28|59003550|gb|AAW83557.1|, |67553093|gb|AAY68680.1|AF36, |26000276|gb|AAN75309.1|

AP32, |12957360|gb|AAK09191.1|AF32

AF32, 112957252|gb|AAK09101.11AF32

112957312|gb|AAK09151.1 |AF32, |48476375 |gb|AAT44409.11AF28, |45738212|gb|AAS75871.1|

AF28, |38892672|gb|AAR27674.1|, |59003639|gb|AAW83637.1|68522136|gb|AAY98723.1|, |13569310|gb|AAK31046.1|AF28, |57869646|gb|AAW57688.167553063 |gb|AAY68653.11, |67553073|gb|AAY68662.1|, |57869610|gb|AAW57656.126000266jgblAAN75300.il, |63098402|gb|AAY32443.1|, |68522056|gb|AAY98651.159003580|gb|AAW83584.1|, |67553113|gb|AAY68698.1|, |12957306|gb|AAK09146.1[AF3212957300|gb|AAK09141.1[AF32, |59003520|gb|AAW83530.1

58221001|gb|AAW68179.1|, |38892709|gb|AAR27707.1|, |68522026|gb|AAY98624.157338565|gb|AAW49359.1|, |46486638|gb|AAS98744.1|, |63098382|gb|AAY32425.159003659|gb|AAW83655.1|, l55139292lgblAAV41312.ll, |68521946|gb|AAY98552.167553007|gb|AAY68603.1|, |12957348|gb|AAK09181.1|AF32

12957342|gb|AAK09176.1|AF32, |67553033|gb|AAY68626.1|, |59003669|gb|AAW83664.132344848|gb|AAM82303.1|, |12957258|gb|AAK09106.1|AF32, |57338557|gb|AAW49352.146486665jgb|AAS98768.1|, |55139322|gb|AAV41338.1|, |24181510|gb|AAN47129.168522106|gb| AAY98696.11, |45738222|gb|AAS75880.1|, |68522155|gb|AAY98740.168521976|gb|AAY98579.11, 115281462|gb|AAK94248.1 |AF36, |67553043|gb|AAY68635.163098287|gb|AAY32340.1 j, |57869656|gb|AAW57697.11, |25166983 |gb|AAN73756.1 |AF48

25166913|gb| AAN73693.1 |AF48,25166873|gb|AAN73657.1 |AF48,25166823 |gb|AAN73612.1 |AF48,25166631 jgb |AAN73440.1 |AF48,25166773 |gb|AAN73567.1 j AF48,32351104|gb|AAP76512.11,25166793|gb|AAN73585.1|AF48,25166803 |gb|AAN73594.1 |AF48,25167063|gb|AAN73828.1|AF48,25166703|gb|AAN73504.1 |AF48,25166691 |gb|AAN73494.1 |AF48,25167043|gb|AAN73810.1 |AF48,25166661 |gb| AAN73467.1 |AF48,25167033 |gb|AAN73 801.1 |AF48,25167053|gb|AAN73819.1|AF48,25166953|gb|AAN73729.1 |AF48,25166651 |gb|AAN73458.1 |AF48,15281422|gb|AAK94212.1|AF36,5059043|gb|AAD38883.1|AF119,18699186|gb|AAL78446.1 |AF41,6690761 |gb|AAF24320.1 |AF197,

[25167003 |gb|AAN73774.1 |AF48|25166853|gb|AAN73639.1|AF48|25166723 |gb|AAN73522.1|AF48]25166963 |gb |AAN7373 8.1 |AF48|25166671|gb|AAN73476.1|AF48|25167013 |gb| AAN73783.1 |AF48|25166843 |gb|AAN7363 0.1 j AF48|25166833|gb|AAN73621.1|AF48|25166903 |gb| AAN73684.1 |AF48|25167023|gb]AAN73792.1 |AJF48|25166753 |gb|AAN73549.1 j AF48[25166713 |gb| AAN73513.11AF48|25167073|gb|AAN73837.1|AF48|38679160|gb|AAR26412.1|[25166813 |gb| AAN73603.1 |AF48|25166733|gb|AAN73531.1|AF48115281482|gb|AAK94266.1 |AF36|5059052|gblAAD38891.1|AF119|1899135|gb|AAC57015.1|

13403228 |gb|AAC29061.11, |62467718|gb|AAX83971.11|5931485 |dbj |BAA84663.11, 111761603 |gb|AAG3 8931.1111761563|gb|AAG38895.1|, |6690755|gb|AAF24314.1|AP197, |5931494|dbj|BAA84671.1|78100202|gb|ABB20905.11, |6690776|gb|AAF24335.1 |AF197

6690769|gb|AAF24328.1 |AF197,

138506|sp|P24737|VIF_HVlU4,

82309894|sp|Q6PT01|Q6PT01_9,

46946846|gb|AAT06636.1|,61102685|gb|AAX37811.11,1107654|emb|CAA62724.11,1107608|emb|CAA62720.1 j,1107620|emb[CAA62699.1|,1107600|embjcAA62711.1 j,61102619|gb|AAX37754.1|,

|3132813|gb|AAC29079.1|,|46946861 |gb|AAT06649. lj,

|46946837|gb|AAT06628.11,|1107648[emb|CAA62718.1|,|61102670|gb| AAX37798.1|,|61102662|gb|AAX37791.1|,11107604|emb|CAA62713.1 j,|1107598|emb|CAA62710.1|,|6110261 l[gb|AAX37747.1|,

|4262339|gb|AAD14575.1||3132803 |gb | AAC29070.11|46946853 |gb|AAT06642.11|46946828|gb|AAT06620.11[1107656|emb|CAA62725.1||1107612|emb|CAA62723.1||61102546|gb|AAX3769 l.lj|1107602|embjCAA62712.1|11890686|gb|AAC97543.11|61102562|gb|AAX37705.1|61102554|gb|AAX37698.11107610|emb|CAA62722.161102538|gb|AAX37684.161102603|gb|AAX37740.117046744|gb|AAL34762.1|56193042|gb|AAV84129.156193059|gb|AAV84138.117046564|gb|AAL34600.1|17046774|gb|AAL34789.1|17046920|gb|AAL34920.1117046514|gb|AAL34555.lj17046754|gb|AAL34771.1|17046584|gb|AAL34618.lj17046794|gb|AAL34807.1 j3252959|gb|AAD 12107.11,17046834|gb|AAL34843.1117046840jgb|AAL34848.1117046860|gb|AAL34866.1117046554|gb| AAL34591.1156131602|gb|AAV80382.117046534|gb|AAL34573.1 j17046714|gb|AAL34735.1126245451 jgbj AAN77381.1

|61102522|gb|AAX37670.1|,|1107632|emb|CAA62697.1|,|61102530|gb|AAX37677.1|,|61102595 jgb|AAX37733.lj,|56193006|gb|AAV841 ll.lj,|56193093|gb|AAV84156.1|,|56193025|gb|AAV84120.1|,117046910|gb j AAL34911.11,117046664|gb|AAL34690.11,117046654|gb|AAL34681.11,jl7046900lgblAAL34902.il,jl7046674lgblAAL34699.il,|26245471 |gb|AAN77399.1 j,117046614|gb| AAL34645.1 j,|3252949|gb|AAD12098.1|,|3252921|gb|AAD12073.1|,|13172884|gb|AAK14232.1|,117046704|gb|AAL34726.11,jl7046824|gb|AAL34834.1|,117046814|gb|AAL34825.1|,117046624|gb|AAL34654.11,117046634|gb| AAL34663.1 j,117046524|gb|AAL34564.11,

5668925 |gb|AAD46077.1|AF076, |1127913|gb|AAA83802.1|,1127909|gb|AAA83 800.1 j, 11127905|gb|AAA83798.11

1127907igbjAAA83799.il,2843169|gb|AAC02322.11,2843143 |gb|AAC02309.1|,2843127|gbjAAC02301.1|,2843141|gb|AAC02308.1|,2843131 |gb|AAC02303.1|,2843163 |gb|AAC02319.11,2843147|gb|AAC02311.1 j,2843145|gb|AAC02310.1|,62291045|sp|P69722|VIF_HVl 1,328556|gb|AAB59868.1|,62291044|sp|P69721 |VIF_HV1B,138494|sp|P04598|VIF_HVlB5,

|3193274jgbjAAD03327.|2843157|gb|AAC02316.1|,|2843167|gb|AAC02321.1|,|2843137|gb|AAC02306.lj,|2843129|gb|AAC02302.11,|2843133|gb|AAC02304.1|,|2843161|gbjAAC02318.1|,j2843155 jgb j AAC02315.1 j

|1107652|emb|CAA62721.1|1107630|embÍCAA62704.1|60218866|gb|AAX14844.1|61102587|gb|AAX37726.1|17046574|gb|AAL34609.1|56193077|gb|AAV84147.1117046764|gb| AAL34780.1117046694|gb|AAL34717.1117046644|gb jAAL34672.1117046544jgb|AAL34582.1117046594jgbjAAL34627.1|17046734|gb|AAL34753.1|26245461|gb|AAN77390.1117046724|gb|AAL34744.1117046850|gb jAAL34857.1|17046890|gbjAAL34893.1j 17046870|gb|AAL34875.1|17046784|gb|AAL34798.1jl7046604jgbÍAAL34636.1|17046804jgb|AAL34816.1|17046880|gb|AAL34884.1|17046684|gb|AAL34708.1|3676483|gb|AAC61988.1|1127911|gb|AAA83801.1|1127903|gb|AAA83797.1jll27954jgbjAAA83822.1|2843159|gb|AAC02317.1|2843165 |gb|AAC02320.1|2843135|gb|AAC02305.1|2843139|gb | AAC02307.1|2843149|gb|AAC02312.1|2843153|gb|AAC02314.1

]2843151 jgb| AAC02313.1j62291047|sp|P69724|VTF_HVlP|62291043|sp|P69720|VIF_HVlB|62291046|sp|P69723 |VIF_HV1H|401363|sp|P31820|VIF_HVlNA|1127952|gb|AAA83821.11, 11127873 |gb|AAA83782.1

1127865|gb|AAA83778.1|, |1127871|gb|AAA83781.1|, |1127867|gb|AAA83779.11055032|gb|AAA81038.1|, |1127968|gb|AAA83829.1|, |82317065|sp|Q5U8A2|Q5U8A2_962548190|gb|AAX86742.11, |62548180|gb|AAX86733.11, |62548200|gb|AAX86751.1'62548170|gb|AAX86724.1 j, |62548160|gb|AAX86715.11, |1772627|gb|AAC32295.182317952|sp|Q6EG63|Q6EG63_9, |37677796|gb|AAQ97472.1|, |37677786|gb|AAQ97463.1549324|sp|P35964|VIF_HVlY2, |138496|sp|P03402|VIF_HVlA2, |327816|gb|AAB03746.1138497|sp|P20877|VIF_HVlJR, |1127956|gb|AAA83823.1|, |37725229|gb|AAR02293.137725219|gb|AAR02284.1|, |37725199|gb|AAR02266.1|, |37725189|gb|AAR02257.182310551 jsp|Q6TEA8|Q6TEA8_9, |37725209|gb|AAR02275.1|, |37725239|gb|AAR02302.137725249|gb|AAR02311.11, |221479|dbj|BAA00994.11, |687903|gb|AAB31804.1|687902|gb|AAB31803.11,lll27937lgblAAA83814.ll,|1127933|gb|AAA83812.1|,lll27929lgblAAA83810.ll,|1127925|gb|AAA83808.1|,|2853520|gb|AAC02394.11,|2853513|gb|AAC02391.1|,|2853506|gb|AAC02388.11,|2853496jgb|AAC02383.11,|2853498|gb|AAC02384.1|,|2853494|gb|AAC02382.lj,113 8503 |sp|P20890| VIF_HV1 OY,118699250|gb|AAL78491.11AF41,

|138502|sp|P12504|VIF_HVlN5,|1127939|gb|AAA83815.1|,|1127917|gb|AAA83804.1|,jl 127921 |gb|AAA83806.1|,|138504|sp|P05900|VIF_HVlRH,|2853525|gb|AAC02396.1|,|2853500|gb|AAC02385.1|,|2853516|gb|AAC02392.1|,|2853504|gb|AAC02387.1|,12853492|gb|AAC02381.1|,Í2853518|gb|AAC02393.1|,|1127948|gb|AAA83819.1|,|2281655|gb|AAB64165.11,

|37677766|gb|AAQ97445.11,j 1127893 |gb|AAA83792.11|1127889|gb|AAA83790.1j|1127879|gb|AAA83785.1!|1127883|gb|AAA83787.1||2853466|gb|AAC02368.11|2853455|gb|AAC02363.lÍ|2853478|gb|AAC02374.1|12853443 |gb|AAC02357.11|2853451]gb|AAC02361.1||2853472|gb|AAC02371.11|2853449|gb|AAC02360.1|12853441 |gb| AAC02356.11

|82317942|sp|Q6EFW4|Q6EFW4_9,

|37677756|gb|AAQ97436.1|,|1127891 |gb|AAA83791.1|,jl 127885|gb|AAA83788.1|,Íll27877|gb|AAA83784.1|,|2853482|gb|AAC02376.1|,|2853464|gb|AAC02367.11,|2853488|gb|AAC02379.1|,|2853476|gb|AAC02373.1 j,|2853439|gb|AAC02355.1|,]2853474|gb|AAC02372.1 j,|2853445|gb|AAC02358.11,|2853480|gb|AAC02375.1 j,|2853470)gb|AAC02370.1],

|37677896|gb|AAQ97562.1|36365546|gb|AAQ86749.1136365411 |gb|AAQ86629.1|36365420|gb|AAQ86637.1|36365375|gb|AAQ86597.1|36365447|gb|AAQ86661.1136365501 |gb|AAQ86709.1|36365528|gb|AAQ86733.1|4205074|gb|AAD10945.1|,|4205056|gb|AAD10929.1|4205002|gb|AAD 10881.1|420503 8|gb|AAD 10913.112853563 |gb|AAC02414.111285358 l|gb|AAC02423.11|2853559|gb|AAC02412.11|2853544|gb|AAC02405.112853575 |gb|AAC02420.11|2853579|gb|AAC02422.11|2853561 |gb|AAC02413.111285353 l|gb|AAC02399.1111127901 |gb|AAA83796.11

|37681533 |gb|AAQ97643.11,136365510|gb|AAQ86717.11,|36365456|gb|AAQ86669.1|,|36365402jgb j AAQ86621.1 j,|36365384|gb|AAQ86605.1|,|36365483|gb|AAQ86693.1|,|36365492|gb|AAQ86701.1|,|36365519|gb|AAQ86725.1|,|4205047|gb|AAD10921.1|,|4204993|gb |AAD 10873.11,|420501 l|gb|AAD10889.1|,|2853583|gb|AAC02424.1 j,|2853546|gb|AAC02406.1|,|2853573|gb|AAC02419.1|,|2853554|gb|AAC02410.11,|2853539|gb|AAC02403.11,|2853565|gb|AAC02415.1|,|2853567jgb | AAC02416.11,|2853552|gb|AAC02409.1|,|285357ljgbjAAC02418.1|,11127899|gb|AAA83795.11,

|1127944|gb|AAA83817.1|1127931|gb|AAA83811.1jll27915jgbjAAA83803.1jll27919ÍgbjAAA83805.1|2853529|gb|AAC02398.1|2853522|gb|AAC02395.1|2853490|gb|AAC02380.1|2853502|gb|AAC02386.1|2853 527|gb|AAC02397.1|2853508|gb|AAC02389.1|2853510|gb|AAC02390.1|5412475 l|gb|AAV30092.1|1127942|gb|AAA83816.1jl 127897|gb|AAA83794.1jll2788ljgbÍAAA83786.1jll27895jgb|AAA83793.1jl 127887|gb|AAA83789.1|2853462|gb| AAC02366.1|2853447|gb|AAC02359.1|2853468|gbjAAC02369.1|2853486|gbjAAC02378.1j2853457|gb|AAC02364.1Í2853484|gb|AAC02377.1|2853453 jgb jAAC02362.1Í2853437jgbjAAC02354.1Í2853459]gbÍAAC02365.1|37677906|gb|AAQ97571.1j37677776jgb|AAQ97454.1Í36365438|gbjAAQ86653.1j36365429jgbjAAQ86645.1Í36365393jgbjAAQ86613.1j36365537|gb|AAQ86741.1Í36365465jgbjAAQ86677.1Í36365474jgbjAAQ86685.1|47118232|gb|AATl 1230.1|4205065 |gb|AAD 10937.1j4205020jgbjAAD 10897.1|4205029|gbjAAD10905.1|2853535|gb|AAC02401.1|2853577jgb|AAC02421.1|2853556|gb|AAC02411.1|2853569jgb|AAC02417.1Í2853537jgbjAAC02402.1|2853548jgb jAAC02407.1|2853542|gbjAAC02404.1j2853533|gb|AAC02400.1|2853550|gb|AAC02408.1|50404190|gb|AAT76860.11127830|gb|AAA83768.1|,

37677856|gb|AAQ97526.1|,

2853407|gb|AAC02341.1|,

2853431 |gb|AAC02352.1 j,

2853369|gb|AAC02323.1|,

2853392|gb|AAC02334.1 |,

2853384lgblAAC02330.ll,

2853403lgblAAC02339.ll,

2853415|gb|AAC02345.1|,

2853390|gb|AAC02333.1|,

2853373|gb|AAC02325.1|,

2853421 |gb|AAC02348.1 j,

1127960|gb|AAA83825.1|,

37677846|gb|AAQ97517.11,

|1127828|gb|AAA83767.1|,|1127970|gb|AAA83830.1|,|2853409|gb|AAC02342.1|2853429|gb|AAC02351.1|,|2853382|gb|AAC02329.1|,|2853388|gb|AAC02332.1|,|2853378jgbj AAC02327.11,|2853380|gb|AAC02328.1|,[2853411 jgb|AAC02343.1 j,|2853386|gb| AAC02331.1 j,|2853419|gb|AAC02347.1|,|2853398|gb|AAC02337.1|,|33359203|gb|AAQ17028.1|,

|37677866|gb|AAQ97535.1|2853434|gb|AAC02353.1|2853423|gb|AAC02349.1|285337 l|gb|AAC02324.1|2853427|gb|AAC02350.1|2853375 jgb|AAC02326.1|2853405|gb|AAC02340.1|2853394|gb|AAC02335.1Í2853400Ígb|AAC02338.1l|2853417|gb|AAC02346.1|2853413|gb|AAC02344.1|2853396|gb|AAC02336.1|37681543 |gb|AAQ97652.1|1127964|gb|AAA83827.1

11127966|gb]AAA83 828.182317948|sp|Q6EG27|Q6EG27_9, |37677836|gb|AAQ97508.1|, |37677826|gb|AAQ97499.166864703 |gb|AAY57429.11, |66864693 |gb| AAY57420.11, |66864683 |gb|AAY57411.137677816|gb|AAQ97490.11, |37677806|gb|AAQ97481.1|, ]54124761|gb|AAV30101.182309893|sp|Q6PSX3)Q6PSX3_9, |82309892|splQ6PSV4|Q6PSV4_9

82309895|sp|Q6PT24|Q6PT24_9, |1127857|gb|AAA83774.1|, |1127855|gb|AAA83773.11127853|gb|AAA83772.1|, |1127851|gb|AAA83771.1|,138500|sp|P05898|VIF_HVlMN, |1127950|gb|AAA83820.1|,

37677876|gb|AAQ97544.11,61102651 |gb|AAX37782.11,61102635|gb|AAX37768.1|,1107634|emb|CAA62706.11,1107670|emb|CAA62732.11,1107666|emb|CAA62730.1 j,1107660|emb|CAA62727.11,1107642|emb|CAA62714.1|,13540184|gb|AAK29350.1|,34330004|gb|AA065890.1 j,1107622|emb|CAA62700.1|,1107616|emb|CAA62705.1|,138507|sp|P04596|VIF_HVlZ65138498|sp|P04597|VIF_HVlEL,

|1127946|gb|AAA83818.1||61102643 |gb|AAX37775.1 \,|61102627|gb|AAX37761.1|,|5805264|gb|AAD51913.1|,11107668|emb |C AA62731.1j 1107662|emb|CAA62728.11,|1107646|emb|CAA62717.1|,11107606jemb |CAA62715.1 j,113540164|gb|AAK29332.11,]34330000|gb|AA065887.1|,11107624|emb|CAA62701.11,|1107614|emb|CAA62696.1|,

|3511262|gb|AAC33784.1|37677886|gb|AAQ97553.lj|1127958jgb|AAA83824.11|61102579|gb|AAX37719.1|1107636|emb|CAA62707.lj|61102677|gb|AAX37804.1||1107664|emb|CAA62729.11|1107658|emb|CAA62726.1||1107644|emb|CAA62716.1|11107638|emb|C AA62708.11|13540174|gb|AAK29341.1||1107626|emb|CAA62702.1||1107628|emb|CAA62703.1111107618|emb|CAA62698.11|138495|sp|P12503|VIF_HVlZ2|138499|sp|P 18805 |VIF_HV IND

32399668|emb|CAD58645.1|,15788299|gb|AAL07746.11,15788249|gb|AAL07701.1 j,55735996|gb|AAV59724.11,47118242|gb | AAT11221.11,55735987|gb|AAV59716.1|,15788259|gb|AAL07710.1|,12407075|emb|CAC24836.1|,

|32399659|emb|CAD58636.1|,|15787961 |gb|AAL07551.11,|15788289|gb|AAL07737.11,|47118262|gb|AATl 1248.1|,|47118222|gb|AATl 1212.1|,|55735952|gb|AAV59685.1|,|55735969|gb|AAV59700.1|,

|47118252|gb|AATl 1239.11115788279|gb |AAL07728.1 \|15788269|gb|AAL07719.1||15788240|gb|AAL07693.1||47118212|gb|AATl 1203.11|55735960|gb|AAV59692.1 j|55735978|gb|AAV59708.1|162467691 |gb|AAX83947.1 j

|12407065|emb|CAC24830.1|138501 |sp|P04599|VTF_HVlMA, |1107650|emb|CAA62719.1|, |1107640|emb|CAA62709.1|3288391|emb|CAA06811.1|, |138521|sp|P17284|VIF_SIVCZ, |463060|gb|AAA99880.1|13172677|gb|AAK14190.1|, |13172707|gb|AAK14215.1|, |13172695|gb|AAK14205.1|13172689|gb|AAK14200.1|, |13172683|gb|AAK14195.1|, |16755646|gb|AAL28058.1|13172701 |gb|AAKl 4210.11, |469242|gb|AAA44861.11, |5531677|gb|AAD44396.1 |AF055,|553l653|gb|AAD44375.1 [AF055, [5531669|gb|AAD44389.1 |AF055,

|553l645|gbjAAD44368.1|AF055, |5531661|gb|AAD44382.1|AF055

Proteínas REV

l60141lembJCAA41586.il, [3226l463|gb[ÀAP76528.1|truncated, [17352349|gb] AALOl 568.1|,J2944135|gb| AAC05242.1[, |4324921|gb|ÀAD17t85.1|, j4324915lgblAAD17179.il»

|4324909|gb|AÂD17173.1|[4324884]jgb j AAD17148 < 1 j,[4324857|gb | AAD 17121.1],|4324836fgb| AAD17100.1|,[4324812|gb|AAD17076.1|,[4324787[gb|AAD 17051.11,[4324761|gb|AAD17025.1 jj,

f4324902|gb|AAD17166.1J,|4324875|gb|AADÍ7l 39.1J,J432485 l|gb|AAD17115. lj,[4324827|gb| AAD17091.11,[4324803|gb[AAD17067.1[,[4324778jgbjAAD17042.1 [,(4324752|gb] AAD 17016.1 j,

[8886637|gb|AAF80536.1]AF179368_6,|3114557|gb|AAD03176.1[, ]3114548[gb|AÁD03168.1|

|2570310|gbfAAC97571.1f,[2570329|gb [AAC32657. lj,|16555085|gb|AAL061404f,116555061 |gb| AAL06137.1[,j 16555037jgb | AAL06134.1 [,|16555005|gb|AAL06l30.lj,jl3560264[dbj|BAB40915.1|,|6580991 jgb|AAF18400.1 |AF190127_8Sjl l993202|gb|AAG42634.11,|5733959|gb]AAD49796.1]AF107771_9,

|2570304|gb|AAC63085.1j,|2570291|gb[ÂAC32648.1|,116555077|gbf AAL06139.11,|16555053|gb[AAL06l36.1|,116555029|gbjAAL0613 3»11,j16554997|gb|AÁL06129.1 j,

11209817|gb] AAB40974.11,[1209811 [gb]AAB40971.1 j,|1209805|gb]AAB4096S. 1[,j1209799|gb[ A AB40965.1 j,[1209793jgblAAB40962. lj,[1209787|gbj AAB40959.1j,]1209781 jgb[AÀB40956.1j,|82321217|sp|Q97255|Q97255_9HTV 1,|82320058|sp|Q9YKX5 |Q9 YKX5_9HTV 1,j82320056|sp|Q9YKW8]Q9YKWS_9HIVl,]82320054[sp|Q9YKV8 |Q9 YKV8_9HTV 1,|82320052|spjQ9YKU8|Q9YKU8_9HIVl,[82320050|sp|Q9YKS9|Q9YKS9_9HIVl,182320048|sp[Q9 YKKS1 Q9 YKR9_9HIVÍ,!82320046|spjQ9YKP6| Q9YKP69HTV1,[82320044|sp|Q9YKN2]Q9YKN2_9HIVl,|82320039]sp|Q9YJH5|Q9YJH5_9HIVl,[82314776]sp|Q97063|Q97063_9HIV1,[82311083jsp[Q75006[Q75006_9HIVl,|82309088|spÍ070894|070894_9HIVl,j82308941 fsp jo41802(041802_9HIY 1,182308939[sp |041787J041787_9HIV1,

11209815]gb]AAB40973.11,|1209809|gb}AAB40970J I,ll209803jgbiAAB40967.il,j1209797|gb|AAB40964.1j,ll209791lgbiAAB40961.il,jl209785fgblAAB40958.ll,1353866|gb[AAB36505J[,

|4324893|gb|AAD17157.1[|4324866[gb| AAD17130.1 j,[4324842[gb| AAD17106.1]4324818|gb | AAD17082.1j,[4324796|gb j AAD17060.1 j,[4324770|gbjAAD17034.1 [,|4324743|gb | AAD17007.11,|3114565[gbjAAD03183.11,[2570319|gb|AAC97579.1 j,j1537056[gb[AAC55464.1 j,|16555093|gb|AAL0614U|,|l6555069[gb|AAL06l38J|,jl6555045|gb|AAL06135.lj,]16555013jgb|AAL06131.lj,j16554989|gb|AAL06128.11,[6581OOOjgbf AAFl8408.1j AFl90128_8,j14530267|gb| AAK65997.1JAF316544_6,]11066503jgbjAAG28618.1jAF259955 6,|5733949[gbjAAD49787,lfAF107770_9,

1209813|gb j AAB40972.1 [,|1209807[gbjAAB40969.1|,|1209801|gb[AAB40966.1|,11209795fgb|AAB40963Λ |,11209789jgb[ÀAB40960■ 1 j,ll209783jgbjAAB40957.ll,11575477|gb|AAB09539.11,182321193|sp[Q9YKM6IQ9YKM6_9HIVl,|82320057|spiQ9YKX2|Q9YKX2_9HIVl,[82320055|$p|Q9YKW2|Q9YKW2_9HIVl,[82320053|spÍQ9YKV3 |Q9 YKV3_9ffiV 1,[82320051 jspíQ9YKU3ÍQ9YKU3_9HIVl}]82320049|sp [Q9YKS3 [Q9 YKS3_9HIV1,|82320047|sp|Q9YKR2|Q9YKR2_9H3Vl,|82320045|sp|Q9YKN9|Q9YKN9_9HIVl,|82320040[sp | Q9 YJK5 |Q9 YJK5_9HIV1,[82320034|sp|Q9YIJ7|Q9YIJ7_9HIVl5]82313586[splQ8UMQO|Q8UMQO_9HIVl,|82309089|sp]070900|070900 9HIV1,j82309087jsp|070890|070890l9HIVl,[82308940|sp|0417961041796_9HIV 1,[82308938jsp|041778jo41778_9HIV 1,82308937|sp|041770|041770_9HTVl, |6466840|gb|AAFl 3055.1

7021459|gb|AAF35358.1|, |2801503|gb|AAC82592.1|, 11123018|gb|AAC54647.1 ]1123008 jgb IAAC5463 8.1|, |1072092|gb|AAC54548.1|, |1151165|gb|AAA85235.lj

665536|gb|AAA76688.1|,82319769|sp|Q9QRX3 |Q9QRX3_9HTV1,82319641 jsp |Q9QEF5 |Q9QEF5_9HIV 1,82319630|sp|Q9Q707|Q9Q707_9HIVl>82319301|sp|Q9IMJ3|Q9IMJ3_9HIVl,82318817[sp|Q9DHB3|Q9DHB3_9HIVl,82314713|sp|Q90Q J8 |Q90Q J8_9HIV 1,82313888|sp|Q900M6|Q900M6_9HIVl,82313886|sp|Q900M4|Q900M4_9HIVl,82313884|sp|Q900M2|Q900M2_9HIVl,82313882|sp|Q900M0|Q900M0_9HIVl,82313880|sp|Q900L8|Q900L8_9mVl,82313878|sp|Q900K2|Q900K2_9HIVl,82313876|sp|Q900K0|Q900K0_9HIVl,82311056]sp|Q74597lQ74597_9HIVl,82311051|sp|Q73334|Q73334_9HIVl,1568314|emb|CAA02188.1|, |1398979|dbj|BAA12993.1|,25565 l|gb| AAB23299.1|, |16555021|gb|AAL06132.1|,82311300|sp|Q77Y21 |Q77Y21_9PLVG,

|9629359|reflNP_057854.1||82319768 |sp|Q9QRW4|Q9QRW4_9HIVl|82319631|sp|Q9Q716|Q9Q716_9HIVl[82319531 |sp|Q9J0G7|Q9J0G7_9HIVl|82318851 |sp|Q9DSM0|Q9DSM0_9HIVl|82318650|sp|Q998E7|Q998E7_9HIVl|82313889|sp|Q900M7|Q900M7_9HIVl|82313887|sp|Q900M5|Q900M5_9HIVl|82313885|sp|Q900M3|Q900M3_9HIVl|82313883|sp|Q900Ml|Q900Ml_9HIVl|82313881 |sp|Q900L9|Q900L9_9HIVl|82313879|sp|Q900L7|Q900L7_9HIVl|82313877|sp|Q900Kl |Q900K1_9HTV1|82311301|sp|Q77YF8|Q77YF8_9HIVl|82311053|sp|Q74088|Q74088_9HTVl|82309086|sp|070677|070677_9HIVl11398970|dbj |B AAl 3001.11|6016893|dbj|BAA85230.1|19629921 jref|NP_046128.11

2828043|gb|AAB99964.11,82319757|sp|Q9QN93|Q9QN93_9HIVl,

3002873|gb|AAD03229.11,912744|gb|AAA82863.1912733|gb|AAA82856.1912724|gb|AAA82850.1912715 |gb|AAA82844.1912704|gb|AAA82837.1912695|gb|AAA82831.1912686|gb|AAA82825.1912677|gb|AAA82819.1912668|gb|AAA82813.1912659|gb|AAA82807.1912650|gb|AAA82801.1912641 |gb|AAA82795.1912632|gb|AAA82789.1912623|gb|AAA82783.1912614|gb|AAA82777.1912605 |gb|AAA82771.1912596|gb|AAA82765.19125 87|gb|AAA82759.17416425|dbj|BAA93860.1|,7416394|dbj |B AA93 845.11,7416398|dbj|BAA93847.1|,7416407jdbj |B AA93 85 l.lj,7416417ldbjlBAA93856.il,

|912750|gb|AAA82867.1|,|912739|gb|AAA82860.11,|912730|gb|AAA82854.1|,|912721 |gb|AAA82848.1 j,|912710|gb|AAA82841.1|,|912701 |gb|AAA82835.lj,|912692|gb|AAA82829.11,l912683lgblAAA82823.ll,|912674|gb|AAA82817.11,|912665|gb|AAA82811.1 j,|912656|gb|AAA82805.1|,|912647|gb|AAA82799.1|,|91263 8 |gb|AAA82793.11,|912629|gb|AAA82787.1 j,|912620|gb|AAA82781.1|,|91261 l|gb|AAA82775.1|,|912602|gb|AAA82769.1|,|912593 jgb j AAA82763.1 j,|912584|gb|AAA82757.1|,|7416419|dbj|B AA93857.1|,|7416421 |dbj |B AA93 85 8.1 j,|7416429|dbj|BAA93862.1|,|7416427|dbj|BAA93 861.11,|7416415|dbj|BAA93855.1|,

|82319609|sp|Q9PXZl|Q9PXZl_9HIVl|821803 l|emb|CAB9279l.lj|912747|gb|AAA82865.1||912736|gb|AAA82858.1||912727|gb|AAA82852.1||912718|gb|AAA82846.11|912707|gb|AAA82839.1 j|912698|gb|AAA82833.1 j|912689]gb|AAA82827.1||912680|gb|AAA82821.1||912671|gb|AAA82815.1||912662|gb|AAA82809.1||912653 jgb |AAA82803.1 j|912644|gb|AAA82797.11|912635|gb|AAA82791.1||912626|gb|AAA82785.1 j|912617|gb|AAA82779.1 j|912608|gb|AAA82773.1||912599|gb|AAA82767.1 j|912590|gb|AAA82761.1||7416431 |dbj |B AA93 863.1 j|7416396|dbj|B AA93846.1||7416401 |dbj|BAA93848.11|7416413jdbj |B AA93 854.11|7416423jdbj jBAA93 859.1 j|7416411 jdbj |B AA93853.1 j|7416409|dbj |BAA93852.1[, |7416405|dbjlBAA93850.1|, |7416403|dbj|BAA93849.1|,118844742jdbj JBAB85464.1j, |1055035|gb|AAA8l04l,l|, |274S746|gb|AAC97530.1|,j3252972jgb|AAD 12119.1| truncada, |3252962|gb|AAD12110.Ijtruncada,

|3252952jgb j AAD12101. if truncada, |3252932|gb|AAD12083.1| truncada,

|3252924]gb|AADL2076.11 truncada, ]3193277[gb|AAD03330.1|, ]3l93269|gb|AAD03323.1|,

j1890689}gb | AAC97546,1[20271245jgb |AAM18556.1| AF493673_ mutante,[20271243jgb |AAMl8555.11AF493672_ mutante,ll7046913lgbjAAL34914.il, 117046903igb| AAL34905.11,

J3378127|gb | AAC28450.1 [,

[17046873]gb|AAL34878»l |117046843jgb j AAL3485 l.lj,117046807jgbJAAL34819.ltJ17046777lgbiAAL34792.il,117046747|gb] AAL34765.1[,jl70467l7lgblAAL34738.il,j17046687|gb[AAL3471 l.lj,|17046657jgbfAAL34684J j,117046627jgb|AAL34657.1|,]17046597jgb|AAL34630.1|,j17046567jgb [AAL34603.1j17046537|gb | A AL34576.1|,jl4630l7|gb|AAB05176.1|,j 15788295 |gb|AAL07743.11,j 15788265Jgb | AAL07716.1 j,[15787963 |gb j AAL07553, 1 j,[13540189[gb j AAK29355.11,|11761601 JgbjAAG3S929,1|,[11761581jgt>]AAG389l 1.11 truncada,

j l7046863|gb|AAL34869.11j 17046827|gbjAAL34837.11,|17046797|gb|AAL34810.1 j,117046767|gb[AAL34783.11,jl7046737lgbjAAL34756.ll,j 17046707jgbjAAL34729.il,|17046677|gb|AAL34702.lj,|17046647|gb|ÁAL34675,lj,j17046617|gb |AÁL34648.11,|17046587|gb IAAL34621.il,117046557|gbj AAL34594.1j,117046527]gb|AÀL34567.11,14209303|dbj|B AB55912.11,115788284]gb| AAL07733.1j15788255jgbj AAL07707.1j,|5805262]gb|AAD519I L1 [,113540179|gb|AA3C29346.11,

[11761561 |gb|AAG38893.11,13098588|gb| AAC68855,11,[1899U7|gb]AAC56999.1[1899101 |gb j AAC56986,11,Í3403224|gb|AAC29058.1 j,Í3132806jgb|AAC29073.1 j,

117046923|gb|ÁAL34923.11,}17046893|gb| AAL34896.11,[17046853|gbjAAL34860.1 j,117046817|gb|AÁL34828.1j,|17046787jgb|AAL34801.1],jl7046757jgb|AAL34774. lj,j 17046727jgb|AAL34747.1],117046697jgb jAAL34720.1 j,|17046667|gb|AAL34693.1|,117046637|gb| AAL34666.1f,|17046607jgb|AAL34639.11,117046577jgb|AAL34612.1(,117046547jgbjAAL34585.il,[17046517|gbÍAAL34558.lt[15788305jgb|AAL07752.1|,|15788275|gb|AAL07725.lj,|157882461gbjAALÍ)7699.li>|l3172886|gb|AAKI4234J|,[13540l691gblAAK29337.il,|11761591 |gb|AAG38920.11 truncada,

jll76157ljgbjAAG38902.il truncada,

13947931

[gb|AAC82621.1|,jl 899132|gb|AAC57012.1 [,j1899106[gb j AAC56990,11,j 1772630|gb|AAC32298.11,j3132816jgb[AAC29082.1[,j2351233jgblAAB68444.il,

|3252942|gbl AAD12092.11,jj3098578jgb]AAC68846.1|,11899111jgbl AAC56994.1j,]3511264|gb| AAC33786.il,13403215lgblAAC29050.11,[2351239jgb|AAB68449.11,[2351228jgbj AAB68438.1 j, l2194192igblAAB6U30.il, |23986256Ígb[AAL12205.1|truiicada,j23986240|gb]AAL12196.1[truncada, |23986226|gb | AALl 2187.11 truncada,

(23986212|gb| AAL12178.11 truncada, |216l6429fgb|AAM6625Ll|,

|21616425|gb| AAM66248.11, |2l6l6420!gb|AAM66244.1|} |216l6415|gbÍAAM66240.11,|21616410|gbf AÁM66236.11, [21616405[gb[AAM66232.1|, j216l6400|gbjAAM66228.1|,j2l 6l6395|gb|AAM66224.1|, |21616390|gb|AAM66220.1 j, |216l6385|gb|AAM66216.1[,|21616380|gb| AAM66212.11, [2l6l6375|gb|AAM66208.1|, |216l6370|gbjAAM66204.1|,|216l6366|gbfAAM66201.1 f, |21616361|gb|AAM66197.1], J18844732|dbj|BABS5455.1[,118643015|gb| AAL74050.1|, |3462804|gb|AAC33102.1|, j3462800]gb|AAC33099.1|,116751267|gb| AAL05342.11, |16751257|gbjAAL05333.1], 116751244jgb|AAL05321.1(,]16751234|gb|AAL05312.1|, |15281504|gbiAAK94286.1jAF361879.6,

|15281494lgbjAAK94277.1|AF361878„6, il5281485jgb[AAK94269.1|AF361877_6,

115281475|gb IAAK94260.1(AF361876J5, |1528i465|gb|AAK94251,1 |AF361875_6,

|15281455[gb| AAK94242.1 [AF361874_6 truncada, j15281445jgb [AAK94233.1 jAF361873_6,11528143 5 |gb| ΑΑΚ94224.1 |AF361872_6, |15281425|gb|AAK94215.1|AF361871_6

j 14530232|gb|AAK65966.1 |AF286236_6, |15982649|gb|AAL09937.1

|3002845|gb|AAD03204.1|, |3002835|gb|AAD03195.1|, |5931497|dbj|BAA84674.1|5931488|dbj|BAA84666.1|, |13517088|dbj|BAB40426.1|, |3779270|gb|AAD03318.1|14530258|gb|AAK65989.1|AF286239_6, |14530250|gb|AAK65982.1|AF286238_6

|13569333|gb|AAK31067.1|AF286235_6, |13569323|gb|AAK31058.1|AF286234_6

113569313 |gb|AAK31049.1 |AF286233_6, j13569303 |gb|AAK31040.1 |AF286232_6

j 13569293 |gb|AAK31031.1 |AF286231_6, |13569283|gb|AAK31022.1|AF286230_6

113569273 |gb|AAK31013.1 |AF286229_6, jl3569263|gb|AAK31004.1|AF286228_6

|13569253|gb|AAK30995.1|AF286227_6, |13569243|gb|AAK30986.1|AF286226_6

113569233 |gb|AAK30977.1|AF286225_6, |13569223|gb|AAK30968.1|AJF286224_6

|13569213 |gb|AAK30959.1 |AF286223_6, |13194604|gb|AAKl 5483.1

|13194602|gb|AAK15482.1|, |13194600|gb|AAK15481.1|, |13194598|gb|AAK15480.1|13194596|gb|AAK15479.1|, |13194594|gb|AAK15478.1|, |13194592|gb|AAK15477.1|11321033|gb|AAG34024.1|, |11321023|gb|AAG34015.1|, |11321013|gb|AAG34006.1|11321003|gb|AAG33997.1|, |11095916|gb|AAG30120.1|AF286365_6

111066493|gb|AAG28609.1 |AF259954_6, |3808284|gb| AAC69310.1

|5305359|gb|AAD41611.1|AP071474_6, |5305347|gb|AAD41601.1]AF071473_6

l3808276lgblAAD13363.ll, |3808266|gb|AAC69302.1|, |3808256|gb|AAC69293.1||3808246|gb|AAC69284.11, |6651488|gb|AAF22336.1 |AP193277_9

|6651477|gb|AAF22325.1 |AF193276_7, |6643034|gb|AAF20395.1|

|6651463 jgbj AAF22315.1 |AF193253_9, |6090970|gb|AAF03417.1|AF075703_5

|5668959|gb|AAD46103.1|AF076998_5, |5668944|gb|AAD46092.1|AF077336_6

|6910973 jgbj AAF31324.11AF146728_6, j5668928jgbjAAD46080.1|AF076475_6

Í5668915jgbjAAD46069.1|AF076474_5, |5668885|gb|AAD46047.1|AF075701_5

|5305482|gb|AAD41670.1|AF075702_5, |5059055|gb|AAD38894.1|AF119820_6

|5059046|gb|AAD38886.1 IAFll 9819_6,

|3002882|gb|AAD03237.11,|3694866|gb|AAC62480.1|,114290025|gb|AAK59209.11,|14289998|gb|AAK59185.1],|62362596|gb|AAX81604.1|,|82321178|sp|Q72819|Q72819_9fflVl,|82311052|sp|Q73371|Q73371_9HIVl,|82311045|sp|Q72855|Q72855_9HIVl,|82311041 |sp|Q72851 |Q72851_9HIV1,|8231103 8|sp|Q72848|Q72848_9HIV 1,182311034|sp|Q72844|Q72844_9HIVl,|82311030|sp|Q72840|Q72840_9HIVl,|82311026|sp|Q72836|Q72836_9HTVl,|82311021 |sp|Q72831 |Q72831_9HIV1,|82311017|sp|Q72827|Q72827_9HrVl,j82311013 |sp|Q72823|Q72823_9HIVl,|82311009jsp|Q72817|Q72817_9HIVl,|82311005|sp|Q72813|Q72813_9HIVl,|82311001|sp|Q72809|Q72809_9HIVl,|82310997|sp|Q72805|Q72805_9HIVl,|82310993|sp|Q72801|Q72801_9HIVl,

|3002864|gb|AAD03221.1),|2281658|gb|AAB64168.1|,114290016|gb|AAK59201.1|14289988|gb|AAK59176.1|,

|3002891 |gb|AAD03245.1|3002855|gb|AAD03213.1||1857266|gb|AAB54109.1||14290007|gb|AAK59193.1||912742|gb|AAA82862.1||62362588|gb|AAX81600.1 j|82320172|sp|Q9YV23|Q9YV23_9HIVl|82311047|sp|Q72857|Q72857_9HIVl|82311043|sp|Q72853 |Q72853_9HIV1|82311040|sp|Q72850|Q72850_9HIVl|82311036|sp|Q72846|Q72846_9HIVl|82311032|sp|Q72842|Q72842_9HIVl|82311028|sp|Q72838|Q72838_9HIVl|82311024|sp|Q72834|Q72834_9HIVl|82311019|sp|Q72829|Q72829_9HIVl|82311015|sp|Q72825|Q72825_9HIVl|82311011 |sp|Q72821 |Q72821_9HIV 1|82311007|sp|Q72815 |Q72815_9HIV1|82311003 |sp|Q72811 |Q72811_9HIV 1|82310999|sp|Q72807|Q72807_9HIVl|82310995 |sp|Q72803 |Q72803_9HIV1|82310991 jsp|Q72799|Q72799_9HrVl|823 l0989jsp|Q72797fQ72797_9HIVl>|S2310985]sp]Q72793|Q72793_9HlVl,|8231098Í jsp|Q72789|Q72789_9HIVl}|823l0977|spÍQ72785ÍQ72785_9HrVli|82310973jsp)Q7278l |Q72781_9HIV1,|82310969|sp|Q72777|Q72777__9HIVl>J82310965]sp|Q72773[Q72773_9HTV 1,[82310961|sp|Q72769|Q72769_9HIV1,|82310957|sp|Q72765JQ72765_9HIV1,(82310953jsp|Q72761 |Q72761_9HIV1,|82310949]sp|Q72757|Q72757_9HIV 1,182310945jsp|Q72753 |Q72753_9HIV1,f82310941 ]sp| Q72749|Q72749_9HI V1,|82309226jsp|P89696|P89696_9ffiVl,|82309121 fsp|090l54|090154_9HIVl|66864696|gb |AAY57423.11,127526991 |emb|CAD43151.1

|82310987|sp|Q72795|Q72795_9HTV 1,|82310983jspiQ72791 |Q72791_9HIV1,|82310979|sp|Q72787|Q72787_9HTVl,|82310975|sp|Q72783 |Q72783_9HIV1,(82310971 jsp [Q72779|Q72779_9HIV 1,|82310967|sp|Q72775|Q72775_9mVl,|823l0963|sp|Q7277l|Q72771_9HIVl,|82310959|sp|Q72767jQ72767 9HIV1,[82310955|sp|Q727631Q72763_9HTVl,j82310951 |sp|Q72759|Q72759_9HlVl,|82310947|sp IQ72755|Q72755J>HIV 1,|82310943jsp|Q727511Q72751_9HIVÍ,182310939|sp|Q72747|Q72747_9HrV 1 ,J82309172|sp|092653|092653_9HTV1,|66864706|gb|AAY57432.1),l66864686jgblAAY574l4.il, [27526993]emb|CAD43152. lj,|25166815jgb| AAN73605,1| AF484496_5,

|25166765|gb|AAN73560.1|AF484491_5, |25166705jgb|AAN73506.1|AF484485_5tnmiadaJ

|56417610|gblAAV90748.1|,|56193062|gb|ÁAV84141.1|,|54124764|gb[AAV30104.1 j,J47118265jgbj AATl 1251,1|,|47118235|gb| A AT11233.1jl732490|gb|AAB38837.1j,(32261500jgb|AAP76561. Ij truncada,]32261480|gb [AAP76543.11 trumada,

l56193096jgblAAV841S9.il,j56193045jgbj AAV84132.1|,|54124754|gb j AAV30095,1|,|47118255|gb| A AT11242Λ147118225jgb|AATl 1215.1 j,11732480jgb IAAB38828.1],

|56l93080[gb|AAV84150.11»j56193009|gb j AAV84114.1 f,|50404188|gb|AAT76858.I|,|47118245|gb I AATl 1224J |,]47118215jgbj AATl 1206.1 j,jl 6755648jgbjAAL28060.1 j,|3226Í490|gb|AAP76552.1| tnmcada,3226I470|gb|AAP76534.1j truncaiU,

|333 59207|gb j AAQ17030.1[26245474jgb|AAN77402.1|,J26245454|gb|AAN77384.1 j,|22596257)gb j AAN03047.1 jAF457054_6,]6690772jgb|AAF24331.1 jAF197340_5,|6690758|gb|AAF24317.1 JAF197338_5,

|1469312fgb|AAB0504841,[14579607[gb| AAK69325.1),ll6118379lgbjAAL12744.il,|16118355Igb]AAL12723.1|,Íl6118316Ígb|AAL12690.1|,|16118286|gb|AAL12663.1|,jl61I8256|gb|AAL12636.lj,|45360194|gb|AAS59227.11,[45360163|gb j AAS59199.1 j,|82320179|sp|Q9YX51|Q9YX51_9HTVl182320176|sp|Q9YV64 jQ9 Y¥64_9HIV 1 trumada,|823l9624|sp|Q9Q6I5|Q9Q6I5_9HlVl,|82319622|sp]Q9Q6H2|Q9Q6H2_9HIV 1,|823193 39|sp|Q9lQP6 |Q9IQP6_9HIVI,j82319337]spjQ9ÍQP4jQ9ÍQP4_9HIVl,]82319335jsp [Q91QP21Q9IQP2_9HIV 1,182319333|sp|Q9IQP0jQ9IQP0_9HIVl,

|328654|gb|AAA80322. Ijt116118399|gblAAL12762.1|,|16118369|gb|AAL12735.1|,116118345 jgbfAALl 2714.11,|16118306 jgbjAAL1268Ll|,j16118276|gbj AAL12654.1|,j45360214|gb|AAS59245.11,145360183|gb[AAS59217.1|45360153 |gb| AAS59190. lj,

i26245464lgblAAN77393.il,1478062|gb| AAB51141 < 11,|6690779|gb j AAF24338.1 |AFl9734l_5,(6690765]gb| AAF24324.11AF19733 9 3,117981624|gb|AAL51094. lj,114579617lgblAAK69334.11,|16118389[gb(AAL12753.lS,{16118361 IgbfAALl2728.1 [,|16118333[gbÍAAL12704.1|,ll611S296jgbiAAL12672.il,|16118266fgb|AAL12645.1|,|45360204|gb|AAS59236a|,(45360173 AAS59208.1|45360143|gb|AAS5918Ll|,|82320178|sp|Q9 YW941Q9YW94 9HTV1,|823l9767|sp|Q9QRB3|Q9QRB3_9HlVl,]82319623|sp |Q9Q6H9|Q9Q6H9_9HIV1,|8231962ljsp | Q9Q6G5 |Q9Q6G5_9HTV 1,|82319338|spjQ9IQP5 |Q9IQP5_9HIV1,(82319336|sp|Q9IQP3 |Q9IQP3_9HIV1,|82319334|sp jQ9IQP 1 |Q9IQP 19HTV1,|82319332|sp|Q9IQN9[Q9IQN9_9HIVl,182319331 |sp|Q9IQN8|Q9lQN8_9HIVl,|82319329|sp |Q9IQN6|Q9IQN6_9HIV 1,]823l9327|sp|Q9lQN4jQ9lQN4_9HrVl>|82319325jsp |Q9IQN2|Q9IQN2_9HIV1,]82319323]sp|Q9rQN0]Q9IQN0_9HIVl,j823l932ljsp|Q9lQM8|Q9lQM8_9HIVlslS23l8824fsplQ9DKG8]Q9DKG8_9mVÍ,

truncada, J82318822jsp|Q9DKF2|Q9DKF2J>fflVl

18231882l|sp|Q9DKE4|Q9DKE4_9fflVl|82318820|sp|Q9DKD5 |Q9DKD5_9HIV 1,182318620|sp|Q994C7|Q994C7_9HIVl,|82318618|spjQ994A9|Q994A9_9fflVl,|82317958jsp|Q6EK22 |Q6BK22_9HIV 1,|82317956|sp|Q6E JV0|Q6EJV0_9HIV1,|82317954|sp|Q6ElQ2|Q6EJQ2_9HIVÍ,J82317879|sp|Q6E6X0|Q6E6X0_9HTV,lJ182317877|sp|Q6E6V6lQ6B5V6_9HIVl>182317875|sp|Q6E6Ul]Q6E6Ul_9HIVlí182317054|sp|Q5S5D0|Q5S5D0__9HíVl,|82317052|sp |Q5 S5B4|Q5S 5B4_9HTV1,|82317050|sp|Q5S594|Q5S594_9HlVl>|82314204|sp |Q90DD71Q90DD7_9HIV 1,|823140ó9]sp|Q908N3|Q908N3_9fflVl,J82314067]sp |Q908L5 |Q908L5 9HIV1,|82314065|sp|Q908J7|Q908J7_9H3VI,|823l4063|sp|Q908H9|Q908H9_9HIVlt182313861]sp|Q8UTr2|Q8UTT2_9HlVlJ|82313S59|sp|Q8UTR4|QSUTR4^9HIVl,[82313857(sp IQ8UXP6 [Q 8UTP6_9HIV 1,[82313855ispJQ8UTM8|Q8UTM8_9HrVl,(82313853ÍspÍQ8UTL0]Q8UTL0_9HIVl,[82313850}sp]Q8UT J2|Q8UTJ2_9H[V1,[82313848|sp|Q8UTH4|Q8UTH4_9HIVl,182313846| sp|Q8UTF6]QSUTF6 9HIV1,1823 l3844|spiQ8UIX»8iQ8UTD8"_9HWl,|82313842| sp|Q8ÜTC0]Q8UTC0_9HlV 1,|82313840[sp|Q8UTA2jQSUTA2_9HIV;3182313838 |sp|QSUT84]Q8UT84_9HIVl,|82313836|sp[Q8OT66]Q8UT66J>HlVÍtj82313834[sp|Q8UT48|Q8UT4S_9HIVls182313832| sp[QSUT3 0]Q8UT3 0_9HIV 1,182313830jsp j Q8UT12]Q8UT 12_9HIV 1,182313827jsp j Q8US Y91Q8US Y9_9HIV1,182313825jsp j Q8USX1 [Q8ÜSX1 9HTV1,182313822|sp j Q8USU4[Q8USU4~9HIV1,]82313820|sp|Q8USS6|Q8ÜSS6_9HIVlI1823133S6jsp|Q8Q2Tl [Q8Q2T1_9HIV mutante,|82313385|sp|Q8Q2TO[Q8Q2TO_9HIV mutante,

jS2319330|sp|Q9IQN7|Q9IQN7J?HIVl,|82319328|sp|Q9IQN5|Q91QN5_9HIVl,[82319326|sp|Q9IQN3|Q9IQN3_9HIVl,|823l9324|sp|Q9IQNl|Q9IQNl_9HIVl,|82319322|sp|Q9IQM9jQ9IQM9 9MV1,|82319068jsp|Q9IBN5|Q9IBN5~9H3Yl,|823 l8823|sp|Q9DKG0|Q9DKG0_9HTVl

trancadatrancada,

|82318682]sp|Q99BZ8|Q99BZ8_9HIVl3[82318619|sp|Q994B 8 jQ994B8_9HI V1,j82317959|sp IQ6BK3 8JQ6EK3 8_9HTV 1,j82317957jsp|Q6EJW6jQ6EJW6_9HIV 1,|823l7955]spjQ6EIR8lQ6EJR8 9HIV1,|82317880|sp|Q6E6X6]Q6E6X6_9HIVI,|82317878|spjQ6E6 W3 |Q6E6W3_9HIV1,|82317876|sp|Q6E6U8|Q6E6U8_9Hrvi,|82317307lsplQ5VCT61Q5VCT6_9HI\a,|82317053lsp|Q5S5C2 IQ5S5 C2_9HIV 1,|82317051]sp|Q5S5 A2|Q5S5 A2_9HIV 1,182314773 |sp|Q90VTO|Q90VTO_9HIVl,182314155[sp|Q909R5|Q909R5_9HIV 1,|82314068[sp|Q908M4|Q908M4_9HIVl,]82314066jsp|Q908K6]Q908K6_9HIV I,|82314064|sp!Q908I8|Q908I8_9HIVl,[82313862|sp [Q8ÜTU1 |Q8UTU1_9HIV1,|82313860|sp]QSUTS3 |Q8UTS3_9HIV 1,|82313 85 81sp|Q8ÜTQ5 |Q8UTQ5_9HIV 1,|82313856Ísp|Q8ÜTN7|Q8UTN7_9mVl,|82313854]sp!Q8UTL9!Q8TJTL9_9HIVl,|82313852|sp|Q8UTKl [QSÜTK1_9HIV1,182313849|sp|Q8UTI3|Q8UTI3_9HIVl,(82313847|spjQ8UTG5 |Q8UXG5_9HIV 1,]S2313845lsp|Q8UTE71Q8UTE7_9HIVl,|82313843|sp|Q8UTC9]Q8UTC9_9HlVl,[82313841 |sp|Q8UTBl |Q8UTB1_9HIV1>(82313839[sp|Q8UT93|Q8UT93_9HIVl,|82313837|sp|Q8UT75|QSUT75_9HIVlJ|82313835|sp|Q8UT57|Q$UT57_9HIVl3(82313833|sp |Q8UT39[QEtJT39_9HlVl,[82313831 |sp|Q8UT21 |Q8ÜT21_9HIV1,(82313828|splQ8USZ8[Q8USZ8_9HIVl,1823l3826|sp|Q8USY0|Q8USY0_9HIVl>182313823jsp|Q8USV3jQ8USV3 9HÍV1,[82313821 |sp|Q8UST5|Q8UST5_9HrVl,i82313632[sp|Q8UMF7[Q8UNF7_9HlVl,

|82312603fsp [Q8 AFF5 ]Q8 AFF5_9HIV11|82312602|sp|Q8AFE6|Q8AFE6J>HIV1,|82312212[sp|Q80159|Q80159_9HIVl,(82311078|sp[Q74903]Q74903_9HIVl,[82311076|sp|Q74901|Q74901_9HIVl,[82311074|sp]Q74899jQ74899_9HTVl,[82311072|spjQ74897|Q74897_9HIVl j[82311070|sp]Q74895|Q74895_9HIVl,|82311068|sp|Q74893|Q74893_9HIVl,|82311066jsp]Q74891 |Q74891_9HIV 1,182311064|sp|Q74889ÍQ74889_9HIVl,182311062]sp|Q74887[Q74887_9HIV 1,[82311058|sp|Q74748[Q74748_9HIVl,(82310819|sp[Q70141 [Q70141 _9H3V 1,|82310550|sp|Q6TEA5[Q6TEA5_9HIVl5|82310548|$p|Q6TE87|Q6TE87_9HrV,lJ|S2310546|sp|Q6TE69|Q6TE69_9fflVl,|82309402|sp|Q5DID6|Q5DID6_9HIV 1,|82309232|sp|P89834[P89834_9HIVl,[82309230|sp|P89828|P89828„9HIVl;[82309228|sp|P89822[P89822_9HrVl»[82309220|sp|P88160|P8 8160JMEÍIV 1,[82309194|sp|092940|092940_9HIV1,[82309124|sp [090292j090292_9HTV 1,|82309Í20|sp|090094]090094_9HIVlj823091191sp [090086)090086J9H3V1 trancada ,182309117|spj090068|090068_9HIV 1 trancada,truncated, |823091151sp|089930[089930„9HJVl,182309103|sp|072612|072612_9HIV 1,182308885[spjQ 12162fO 12162_9ΗΓν 1,

|78100205]gb|ABB20908,l|,|74273465]gb[ AB AO1447.1|,[74273436|gb | AB AO1421 .IJ5j74273406lgblABA01394.il,|74273364 |gb| AB AO1358.1[,

|74315774jgb |ÁB A02497.11 trancada „

|74273484|gb|ABA01464.1|j|74273455|gb|ABA01438Λ.],[74273426|gb j AB AOl 412.11,[74273396[gb | AB AO13 85.11,|74273342|gb] AB AO1339.11,

|74315754jgb | ABA02479.1|64310622|gb |AAY41252.1 [,|62946406jgb|AAY22383.1 j,j57869716|gb]AAW57751.1|,[57869689|gb[AAW57727,1],[57869ó59|gb|AAW57700.1],|57869622|gbjÀAW57667.1|,|57869593|gb| AAW57641.1],|57869564|gbjAAW57615.1118699245|gb|AAL78487.11AF414005_3 ,118699171 |gb|AÂL78437.1 |AF413981_4,

|74315744|gb] AB A02470.1 [,[64310551lgblAAY41246.il,l57869734jgblAAW57767.il,[57869706|gb[AAW57742.1|57869679[gb[AÀW57718.1|,|57869649[gb|AAW57691. l|t[57869613lgblAAW57659.il,[57869584[gb | AAW57633.11,[57869556|gb | AA W57608.1 j,

|60218869]gb[AAX14847.1155740231 |gb| AAV63805.1 j,

|55740250|gb|AAV63822.1 [,(45361204[gb[AAS59395.1 [,

|82312601jsp[Q8AFD7|Q8AFD7_9HIVl,J82311079|sp|Q74904|Q74904_9HIV I,]82311077|sp|Q74902|Q74902J9HIV 1,}82311075|sp|Q74900|Q74900_9HIVl,j82311073|sp|Q74898|Q74898_9HIV 1,|82311071 |sp|Q74896IQ74896 9HIV1,182311069|splQ74894|Q74894_9HIVl,182311067|sp|Q74892|Q74892_9HlVl,[82311065|sp|Q7489Ô|Q7489Ò_9HIVl,(82311063jsp|Q74888|Q74888_9HIVl,|82311061jsp [Q74886[Q74886_9HIV1,|82311055jsp |Q74457|Q74457_9HTV 1,|82310552|sp|Q6TEB4[Q6TEB4_9HrV I5|82310549|spjQ6TE96jQ6TE96_9HIVl,]82310547|sp]Q6TE78lQ6TE78_9HIVl}J82310545Jsp|Q6TE60|Q6TE60_9HIV 1,|82309247[sp|P90444[P90444_9HIVl,[82309231fsp |P89831 ]P89831_9HIV1,]82309229[sp|P89825]P89825_9HIVl,J82309227| sp |P89818JP89818__9HIV1,|82309219|sp |P88154JP88154_9HIV1,[82309132|sp[09í 084|091084_9HIV1,!82309122|sp|090176|090l76_9HIVl,

trancada,

182309118jspj09Q077|090077_9EHVl,[82309116|sp|0900611090061_9HTV 1[823091Q4]sp|072617|072617_9HIV1,182309102[sp|071969]071969_9HIV1,|74099687|gbjAAZ289Q4.11,174273475|gb [ AB AO1456.1|,[742734461gbiABA01430.ll,|74273416fgb|AB AO1403.1j,l74273368lgblABA01361.il,|74315784|gb|ABA02506.1j,[74315764|gb[ABA02488.11,174315727|gb|ABA02455.11,|64310508|gb] AAY41243. 1|,57869725|gb[AAW57759.11,5 7S69698|gb| AAW5773 5.11,!57869669|gb| AAW57709.11,57869630|gb| AAW57674.11,57869603|gb|AAW57650.11,57869574|gb| AAW57624.1 j,57869547[gb| AAW57600.11,118699174|gb|AAL78439.1] AF413982_2,|18699165|gb(AAL78432.ljAF413980_3)

155740241 |gb | AAV6381.4.11,|45361192fgb| AAS59386.1(45361179(gb| AAS593SO. 1 [,|45361152|gb|AAS59364.1(45361118|gb|AAS59337.1(,|45361080|gb | AAS59310.11,|62467716|gb j AAX83970.1],l52421742lgbjAAU45381.il,|51950715|gb|AAU14908.1]5|26000269|gb] AAN75303.11 truncada,(25167075jgb j AAN73839.1 |AF484522_5,|25167055jjgb) AAN73821.1JAF484520_5,|25167035(gb|AAN73803.1|AF484518_5,(25167015(gb|AAN73785.1 (AF484516_5,(25166995|gbfAAN73767.1 [AF484514^5,|25166975|gb(AAN73749,1 (AF484512_5,|25166955jgb [AAN73731.1 (AF484510_5,|25166935jgb|AAN73713.1 |AF48450S_5,|25166915|gb|AAN73695.1 |AF484506_5,(25166895|gb | AAN73677.1 |AF484504_5,]25166875jgb | AAN7365S. I |AF434502_5,

|45361171(gb(AAS59375.1j,(45361 l40jgbjAAS59355.1 j,|45361106|gb(AAS59328.1j,|4536l070(gb(AAS59301.1j62467706(gb(AAX83961.1|I|62467696fgb|AAX83952.1],(3288394|emb|C AA06814.1 (,

]25166855Sgb( AAN73641(25166835jgb] AAN73623]25166805|gb|AAN73596]25166785(gbjAAN73578(25166755|gbj AAN73551(25166735jgbj AAN73 533.(25166715jgb j AAN73515|25166693|gb j A AN73496(25166673 |gb(AAN73478]25166653|gb|AAN73460.|25166634 jgb| AAN73443(41400298jgbj AASO1344.155735981 |gb(AAV59711(55735954(gbj AA V5968Ί,Í36365549|gbjAAQ86752.(36365522]gbj AAQ86728,(36365495jgb j AAQ86704,|36365468|gb|AAQ86680.|36365441jgb|AAQ86656|36365414|gb j AAQ86632j36365387|^>|AAQ86608(5613l605)gb|AAV80385|51599134|gbJ AAUO 8219|29409319[gjblAAM67397[39777439|gb j AAR31015(39777409|gb[AAR309S8|39777379| gbj AAR30961♦(38491920jgb|AAR22285.|38491885|gb(AAR22254.

.1[AF484500_5,1|AF484498_5,1|AF484495_5,1|AF484493_5»1|AF4S4490_5>ljAF484488_5s1(AF484486_5>1IAF484483 5,1[AF484481_5,1(AF484479_5,1(AF484477_6}1(, [55735999|gb|AÀV59727.1(,1(, |55735972|gb|AAV59703.1 j,lj, |45644394|gb(AAS72948.1|,IU (36365540|gbjA AQ86744.1lj, |36365513| gb j AAQ86720.1IJj (36365486lgblAAQ86696.il,1), (36365459|gb(AAQ86672.1 |,.1|, (36365432|gb|AAQ86648.lj>1(, (36365405|gbjAAQ86624.lj,1|, [36365378|gb(AAQ86600.! !,lj, [46946856|gb[AAT06645.11,lj, (47027393(gb| AAT08773.1 [,.1[, (29409311 [gb] AAM67390.1 j,lj, |39777429[gb]AAR31006.11,lj, |39777399|gb|AAR30979.1],1|, (38491941 |gbSAAR22304.1|,11, (38491904|gb|AAR22271.1j,Ifj |38491875]gb|AAR22245.1|,

|45361159[gb(AAS59368.1 (,(45361128|gb|AAS59346,1 j,|45361094(gb|AAS593l9.1 (,162467721 [gbjAAX83974.1 (,|52421753[gbj AAU45389.11,[51950725|gbjAAU14917.1|,[26000279[gb {AAN75312.1 j,]260G02S9]gb[AAN75294.1|25l67065|gbjAAN73830.1|AF484521_5,|25167045}gb| AAN73812.1 |ΑΡ484519_5>(25167025jgbj AAN73794,1| AF484517_5,(25167005jgbj AAN73776.11AF484515_5,[25166985[gb|AAN73758.1(AF484513_5,(25166965(gb( AAN73740.1|AF484511_5,(25166945(gbfAAN73722,1 |AF484509_5,|25166925|gb|AAN73704.1 (AF484507_5,[25166905|gb|AAN73686.1 (AF484505„5,[25166885jgbj AAN73668.1 (AF484503_5,[25166865 [gb [ AAN73650JI AF484501_5.

[25166845|gb| AÂN73632,11AF484499_5,|25l66825|gb|AAN736l4.1|AF484497_5,l25166795jgb(AAN73587.ljAF4S4494_5J[25166775(gb| AAN73569.1(AF484492 5,[25166745|gb j AAN73542.1 (AF484489_5,j25166725jgbj AAN73524.1 j AF484487_5,]25166699(gb] AAN73501.1 j AF484484_1,|25166683jgbjAAN73487.1 j AF484482 5,[25166663(gbj AAN73469.1J A!F484480_5,(25166643jgb]AAN7345 U]AF484478_5,[23194117]gb [AAN15025.1 j,l55735990fgbiAAV59719.il,j55735963jgblAAV59695.il,[45644386|gb|AAS72941.1 j,l36365531fgblAAQ86736.il,(36365504(gb | AAQ86712.1],j36365477[gbjAAQ86688.1,j36365450|gb|AAQ86664.1j,|36365423[gb| AAQ86640.1|,l36365396lgblAAQ86616.ll,l56193028lgblAAV84123.il,|51599144|gb[AAU08228,1(29409331 lgbjAAM67407.il,[294093OOjgbj AAM67380. lj,[39777419 jgb1AAR30997.1j,j39777389|gbj AAR30970.1 j,13849193 l|gb[AAR22295.11,js8491894jgb j AAR22262.1 [,[38491865[gbjAAR22236J j,|3 8491856|gb|AAR22228.11,|38491826|gb| AAR22201.11,|38491796|gb| AAR22174.1|,|38491767|gb|AAR22148.1|,|38491739|gb|AAJR22123.1|,|38491708|gb|AAR22096.1|,|38491683|gb|AAR22074.1|,|38491653Ígb|AAR22047.1|,|38491623|gb|AAR22020.1|,|38491601 |gb|AAR22001.11,l38491571lgblAAR21974.ll,|38491541 |gb|AAR21947.1|,|3 8491515|gb| AAR21924.1 j,|38491485|gb|AAR21897.1|,|37683022|gb|AAQ98580.11,|37682993 |gb|AAQ98554.1|,]37682963 |gb|AAQ98527.11,Í37682933|gbjAAQ98500.1|,

j37682905igbjAAQ98475.Íj, Í37ó82894[gbjAAQ984ó6.1j,

|38491846|gb|AAR22219.1|,|38491816|gb|AAR22192.1|5|38491786|gb|AAR22165.1|,|38491759|gb|AAR22141.1|,|38491728|gb|AAR22114.1|,|38491700|gb|AAR22089.1|,|38491673|gb|AAR22065.11,|38491643 jgbj AAR22038.1 j,|38491617]gb|AAR22015.1|,138491591 |gb|AAR21992.1|3l38491561lgblAAR21965.ll,|38491532|gb|AAR21939.1|,|38491505|gb|AAR21915.1|,|37683042|gb|AAQ98598.1|,|37683013|gb|AAQ98572.1|,|37682983|gb|AAQ98545.1|,|37682953|gb|AAQ98518.11,|37682923|gb|AAQ98491.1|,

|37682877|gb|AAQ98451.11,|37682866|gb|AAQ98443.1|,|37682836|gb|AAQ98416.1|,|37682806|gb|AAQ98389.1|,|37682776|gb|AAQ98362.1|,|37682746|gb|AAQ98335.1 j,|37682716|gb|AAQ98308.lj,|33331470|gb|AAQ10915.1|,|4336338|gb|AAD17764.1|,|37935984|gb|AA047221.11,|37935955|gb|AA047195.1|,|37935925|gb|AA047168.1|,|37935895|gb|AA047142.1|,|37935865|gb|AA047116.1|,|30269371|gb|AAP29649.1|,|32189804|gb| AAP75715.1 j,|23394931|gb|AAN31652.1|,|32344851 |gb|AAM82306.11,|33328203|gb|AAQ09551.1|,|25807942|gb|AAN74529.1|30027261 jgbj AAP06264.11,|29119329|gb|AA063244.1|,|29119301|gb|AA063219.1|,|29119271 |gb|AA063192. lj,|24754009|gb|AAN64127.11,|24753977|gb|AAN64100.1|,|24181513|gb|AAN47132.11,|24181483|gb|AAN47105.1|,|22596579|gb|AAN03333.1|AF457090_6,

|37682875|gb|AAQ98450.1|,|37682856|gb|AAQ98434.1|,|37682826|gb|AAQ98407.1|,|37682796|gb|AAQ98380.1|,|37682766|gb|AAQ98353.1|,|37682736|gb|AAQ98326.11,|37682706|gb|AAQ98299.1 j,|33331460|gb|AAQ10906.1|,|37935589|gb|AA065562.1|,|37935974jgb | AA047212.11,|37935945|gb|AA047186.11,|37935915|gb|AA047159.1|,|37935884|gb|AA047133.1|,|37935855 |gb|AA047107.1|,|19908412|gb|AAL96767.1|,

|28933407|gb|AA062621.1 )AF468970_6|23394924|gb|AAN31646.11, |33390885|gb|AAQ17104.1

|38491836|gb|AAJR22210.1|38491806|gb|AAR22183.1|38491776|gb|AAR22156.1|38491749|gb IAAR22132.1|38491718|gb|AAR22105.1|38491692|gb|AAR22082.1|3 8491663 |gb|AAJR22056.1[38491633jgb j AAR22029.1|38491610|gb|AAR22009.1|38491581|gb|AAR21983.1|3 8491551 |gb|AAJR21956.1|38491524|gb|AAR21932.1|3 8491495|gb| AAR21906.1|37683032|gb|AAQ98589.1|37683003|gb|AAQ98563.1|37682973|gb|AAQ98536.1|37682943|gb|AAQ98509.1|37682915 |gb|AAQ98484.1

Λ ΛΟΟΟ/Ι^Τ 1

ρ / UO^OUTjgujrxrw^^ι .χ

|37682873 |gb| AAQ98449.1|37682846|gb|AAQ98425.1|37682816|gb|AAQ98398.1|37682786|gb|AAQ98371.1|37682756|gb|AAQ98344.1|37682726|gb|AAQ98317.1|33331480|gb|AAQ10924.1|4336347|gb|AADl 7773.1|37909410|gb|AA065571.1|37935964|gb|AA047203.1|37935935|gb|AA047177.1|37935904|gb|AA047150.1|37935875|gb|AA047125.1|37935845|gb|AA047098.1|34811838|gb|AA040781.1

132344841 |gb|AAM82297.11,|33328193|gb|AAQ09542.1|,|25807932|gb|AAN74520.1|,|29119347|gb| AA063260.11,|29119320|gb|AA063236.1|,|29119291 |gb|AA063210.1|,[29119264|gb|AA063186.11,|24753999|gb|AAN64118.1|,|24753966|gb|AAN64091.1|,|24181503|gb|AAN47123.1|,

]33328325|gb|AAQ09614.1|3072041 l|gb|AAP33679.1|30038319|gb|AAP12632.1|29119335|gb | AA063249.1|29119310|gb|AA063227.1|29119281|gb|AA063201.1|26518642|gb|AAN83916.1|24753988|gb|AAN64109.1|24753954|gb|AAN64081.1|24181493|gb|AAN47114.1

|22596584|gb|AAN03337.1|AF457091_l|22596569|gb|AAN03324.1]AF457089_6|22596559|gb|AAN03315.1 |AF457088_6, |22596549|gb|AAN03306.1|AF457087_6

|22596539|gb|AAN03297.1 |AF457086_6, |22596529|gb|AAN03288.1|AF457085_6

|22596519|gb|AAN03279.1|AF457084_6, |22596509|gb|AAN03270.1|AF457083_6

|22596499|gb|AAN03261.1 |AF457082_6, |22596489|gb|AAN03252.1|AF457081_6

|22596479|gb|AAN03243.1|AF457080_6, |22596469|gb|AAN03234.1|AF457079_6

|22596459|gb|AAN03225.1|AF457078_6, |22596449|gb|AAN03216.1|AF457077_6

|22596436|gb|AAN03205.1 |AF457075_6, |22596424|gb|AAN03195.1|AF457073_6

|22596414|gb|AAN03186.1 |AF457072_6, |22596403|gb|AAN03177.1 |AF457070_6

|22596393|gb|AAN03168.1|AF457069_6, |22596383|gb|AAN03159.1|AF457068_6

|22596373 |gb| AAN03150.1 |AF457067_6, |22596363|gb|AAN03141.1 |AF457066_6

|22596353|gb|AAN03132.1|AF457065_6, |22596343|gb|AAN03123.1|AF457064_6

122596333 |gb| AAN03114.1 |AF457063_6, |22596323 |gb|AAN03105.1 |AF457062_6

|22596313 |gb| AAN03096.1 |AF457061_6, |22596298|gb|AAN03083.1|AF457059_6

|22596288jgbj AAN03074.11AF457058_6, |22596277|gb|AAN03065.1|AF457056_6

|22596267|gb|AAN03056.1|AF457055_6, |22596247|gb|AAN03038.1|AF457053_6

|22596237|gb|AAN03029.1|AF457052_6, |22596227|gb|AAN03020.1|AF457051_6|2286139|gb|AAB64285.1|, |2286130|gb|AAB64277.1|, 117902153 |gb|AAL47816.1!l7902142jgb!AAL47807-l L !17902131leblAAL47798.1|., |17902120|gb|AAL47789.1|17902109|gb|AAI47780.lt jl7902098jgbÍAAL47771.lj, |17864056|gb|AAL47049.1117864046|gb|AAL47040.1117864036|gb|AAL47031.1

|22532297|gb| AAM97890.1 |AF492624_6, |22532287|gb|AAM97881.1 |AF492623_6

|22532145|gb|AAM97856.1|AF460974_6, |22532136|gb|AAM97848.1|AF460972_6

|22297045|gb| AAM94501.11,

11465782|gb|AAB05603.11,

|60652141|gb|AAX33205.1|,

|60652108jgb|AAX33175.1|,

|60652078|gb|AAX33148.11,

|60652050|gb|AAX33123.1],

|60652020|gb|AAX33096.1|,

|60651991 |gb|AAX3 3070.1 j,

|60651961|gb|AAX33043.1|,

|60651931 |gb|AAX33016.11,

|60651902jgb jAAX32990.1 j,

|60651872|gb|AAX32963.1 j,

|60651843|gb|AAX32937.11,

|60544782|gb|AAX22728.1|,

|71726027|gb|AAZ39157.1|,

|71725997|gb|AAZ39130.1|,

|71725967|gb|AAZ39103.1|,

|62956392|gb|AAY23 525.11,

|62956360|gb|AAY23496.1|,

|83026800|gb|ABB96437.11,

|14579597|gb|AAK69316.1|,

|82571391|gb|ABB84150.1|,

|82571364|gb|ABB84126.1|,

|82571334|gb|ABB84099.1|,

|82571304|gbjABB84072.lj,

|82571274|gb|ABB84045.1|,

|902804|gb|AAB60576.1|1171170|gb|AAA86251.1|60652128|gb|AAX33193.1|60652098|gb|AAX33166.1|6065207 l|gb|AAX33142.1|60652040|gb|AAX33114.1|6065201 l|gb|AAX33088.1|60651981|gb|AAX33061.1|6065195 l|gb|AAX33034.1|60651921 |gb|AAX33007.1|60651892|gb|AAX32981.1|60651862|gb|AAX32954.1|60651833|gb|AAX32928.1|71726047|gb|AAZ39175.1|71726017|gb|AAZ39148.1|71725987|gb]AAZ39121.1|71725957|gb|AAZ39094.11162956381 |gb|AAY23515.1|83026818]gb|ABB96453.1|83026790|gb|ABB96428.1|82571411|gb|ABB84168.1|82571384|gb|ABB84144.1|82571354|gb|ABB84117.1|82571324|gb|ABB84090.1(82571294]gb|ABB84063.11|82571265|gb|ABB84037.1

|818220|gb|AAB47932.1|326428|gb|AAA44219.1|60652118 |gb|AAX33184.1|60652088|gb|AAX33157.1|60652060|gb|AAX33132.1|60652030|gb|AAX33105.1160652001 |gb|AAX33079.1|60651971 |gb|AAX33052.1|60651941 |gb|AAX33025.116065191 l|gb|AAX32998.1]60651882|gb|AAX32972.1|60651852|gb|AAX32945.1|60544792|gb|AAX22737.1|71726037|gb|AAZ39166.1|71726007|gb|AAZ39139.1|71725977|gb|AAZ39112.1|62956404|gb|AAY23536.1|62956371 |gb|AAY23506.1|83026810|gb|ABB96446.1|83026780|gb|ABB96419.1[82571401 |gb|ABB84159.1|82571374|gb|ABB84135.1|82571344|gb|ABB84108.1|82571314|gb|ABB84081.1|82571284|gb|ABB84054.1|82571255|gb|ABB84028.1|82571245|gb|ABB84019.1|,|82571206|gb|ABB83984.1 j,|82322076|sp|Q50D72|Q50D72_9HIVl,|82322070|sp|Q50D56|Q50D56_9HIVl,|82321307|sp|Q507E4|Q507E4_9HIVl,|82321301|sp|Q507Cl|Q507Cl_9HQVl)|82321027|sp|Q52VK9|Q52VK9_9HIVl,|82320171 |sp|Q9YVl 6|Q9YV16_9HIV1,|82320169|sp|Q9YUZ5|Q9YUZ5_9HIVl,|82320028|sp|Q9WSE6|Q9WSE6_9HIVl,|82319988 |sp|Q9WQI4|Q9WQI4_9HIV 1,|82319978|sp|Q9WLH7|Q9WLH7_9HIVl,|82319893|sp|Q9WIR9|Q9WIR9_9HIVl5|82319793|sp|Q9WC58|Q9WC58_9HIVl,|82319773 |sp|Q9QST5 |Q9QST5_9HIV1,|82319771 |sp|Q9QSR8 |Q9QSR8_9HIV1,|82319756|sp|Q9QML7|Q9QML7_9HIVl,|82319754|sp|Q9QM85|Q9QM85_9HIVl,|82319628|sp|Q9Q6Xl|Q9Q6Xl_9HIVl,|82319626|sp|Q9Q6V2|Q9Q6V2_9HIVl,j82319476jsp |Q9IW65 |Q9IW65_9HIV 1,|82319473 |sp|Q9IW39|Q9IW39_9HIVl}|82319469|sp|Q9IV90|Q9IV90_9HIVl,|82319102|sp|Q9IDV4|Q9IDV4_9HIVl,[82319100|sp|Q9ID91 |Q9ID91_9HIV 1,|82318834|sp|Q9DQl 1|Q9DQ1 l_9fflVl,|82318812|sp|Q9DGV0|Q9DGV0_9HIVl,|82318634|sp|Q994R7|Q994R7_9HIVl5|82318632|sp|Q994P9|Q994P9_9HIVl,|82318630|sp|Q994Nl |Q994N1_9HIV1,|82318627|sp|Q994L3 |Q994L3_9HIV1,|82318625 |sp|Q994J5|Q994J5_9HIVl,|82318623 |sp|Q994H7|Q994H7_9HIVl,|82318621|sp|Q994F9|Q994F9_9mVl,|82318610|sp|Q993N3|Q993N3_9HIVl,182318608|sp|Q993Nl |Q993N1_9HIV1,182318606|sp|Q993M9|Q993M9_9HIVl,|82318433|sp|Q6JP20|Q6JP20_9HIVl,182318431 |sp|Q6JP02|Q6 JP02_9HIV1,182318429|sp|Q6JNX5 |Q6JMX5_9HIV 1,|82318427|sp|Q6MV7|Q6JNV7_9HIVl,|82318425|sp|Q6JNT9|Q6JNT9_9HIVl,|82318423|sp|Q6JNS 1 |Q6JNS 1_9HIV1,|82318421 |sp|Q6JNQ3|Q6JNQ3_9HIVl,|82318419|sp|Q6XNN5|Q6JNN5_9HIVl,|82318417|sp|Q6JNM0|Q6INM0_9HIVl,|82318415|sp|Q6JNL8|Q6JNL8_9HIVl,|82318413 lsp|Q6JNK3 |Q6INK3_9HIV1,

|82571235|gb|ABB84010.1|,

|82571225|gb|ABB84001.1|82571196|gb|ABB83975.1|82322073 |sp|Q50D63|Q50D63_9KQYl|8232131 l|sp|Q507F0|Q507F0_9HIVl|82321303|sp|Q507C9|Q507C9_9HIVl|82321298|sp|Q507B5|Q507B5_9HIVl|82320177|sp|Q9YW0|Q9YVF0_9HTVl|82320170|sp|Q9YV02|Q9YV02_9HIVl|82320029|sp|Q9WSF5|Q9WSF5_9HIVl|82320027|sp|Q9WS47|Q9WS47_9HTVl|82319987|sp|Q9WQH6|Q9WQH6_9HIVl|82319977|sp|Q9WLH0|Q9WLH0_9HIVl|82319794|sp|Q9WC67|Q9WC67_9HTVl|82319774|sp|Q9QSU4|Q9QSU4_9HIVl|82319772|sp|Q9QSS6|Q9QSS6_9ffiVl|82319770|sp|Q9QSQ9|Q9QSQ9_9ffiVl|82319755|sp|Q9QMK9|Q9QMK9_9HIVl|82319629|sp|Q9Q6Y8|Q9Q6Y8_9HIVljS2319627jspjQ9Q6W0jQ9QóW0_9HTv 1|82319545|sp|Q9JAC3|Q9JAC3_9HIVl[82319475 |sp|Q9IW48 |Q9IW48_9HIV1|82319470|sp|Q9IV99|Q9IV99_9HIVl182319468|sp | Q9IV14|Q9IV 14_9HTV 1|82319101 |sp|Q9IDA0|Q9IDA0_9HrVl|82318835|sp|Q9DQ28|Q9DQ28_9HTVl|82318833 |sp]Q9DQ04lQ9DQ04_9HIVl|82318651|sp|Q998H3|Q998H3_9HTVl|82318633|sp|Q994Q8|Q994Q8_9HIVl|82318631 |sp|Q994P0|Q994P0_9HIVl|82318629|sp|Q994M2|Q994M2_9HIVl|823186261sp |Q994K4|Q994K4_9HIV 1|82318624|sp|Q994I6|Q994I6_9HIVl[82318622|sp |Q994G8 |Q994G8_9HTV 1|82318611|sp|Q993N4|Q993N4_9HIVl|82318609|sp|Q993N2|Q993N2_9HIVl|82318607|sp|Q993NO|Q993NO_9HIVl|82318605 |sp|Q993M7|Q993M7_9HIV 1|82318432|sp|Q6JPl 1 |Q6JP11_9HIV1|82318430|sp|Q6JNY4|Q6JNY4_9HIVl|82318428|sp|Q6JNW6|Q6JNW6_9HIVl|82318426|sp|Q6JNU8|Q6JNU8_9HIVl|82318424|sp|Q6JNT0|Q6JNT0_9HIVl|82318422|sp|Q6JNR2|Q6JNR2_9HIV 1|82318420|sp|Q6JNP4|Q6INP4_9HIVl|82318418|sp|Q6JNM6|Q6INM6_9HIVl|82318416|sp|Q6JNL9|Q6JNL9_9HIVl|82318414|sp|Q6JNL2|Q6JNL2_9HIVl|82318412|sp|Q6JNJ4|Q6JNJ4_9HIVl|82318411 |sp|Q6 JNI5 |Q6JNI5_9HIV1,|823l8408|sp|Q6JNG9|Q6JNG9_9fflVl,|82318406|sp|Q6INFl |Q6JNF1_9HIV1,|82318404|sp|Q6JNC4|Q6JNC4_9HIVl5|82318402|sp|Q6JNA6|Q6JNA6_9HIVl,|82318400|sp|Q6JN89|Q6JN89_9HIVl,|82318398|sp|Q6JN71|Q6JN71_9HIVl,|82317975|sp|Q6HlS9|Q6HlS9_9HIVl,|82317973|sp|Q6HlRl|Q6HlRl_9HIVl,|82317971|sp|Q6HlP3|Q6HlP3_9HIVl,|82317969|sp|Q6HlM5|Q6HlM5_9HIVl)|82317950|sp|Q6EG60|Q6EG60_9HIVl,|82317947|8ρ|<26Ε024|(26Ε024_9Ηΐνΐ,|82317944|sp|Q6EFY8|Q6EFY8_9fflVl,|82317941|sp|Q6EFWl|Q6EFWl_9HIVl,|82317937|sp|Q6EFM3|Q6EFM3_9HIVl,|82317781 |sp|Q69GT2|Q69GT2_9HIVl,|82317779jsp|Q69GR4|Q69GR4_9HIVl,j823i7777jspjQ69GPójQõ9GFó_9HrvÍ,|82317775|sp|Q69GM8|Q69GM8_9EQVl,|82317643|sp|Q673U6|Q673U6_9HIVl,|82317641 |sp|Q672T7|Q672T7_9HIVl5|82317639|sp|Q672Sl|Q672Sl_9HIVl5|82317632|sp|Q66TS6|Q66TS6_9HIVl,|82317630|sp|Q66TQ7|Q66TQ7_9HTVl,|82317484|sp)Q5VGP8|Q5VGP8_9HIVl,|82317197|sp|Q5UEG7|Q5UEG7_9HIVl,|82317085|sp|Q5U9B2|Q5U9B2_9HIVl,|82317083|sp|Q5U995|Q5U995_9HIVl,|82317081 |sp|Q5U980|Q5U980_9HIVl,|82317079|sp|Q5U962|Q5U962_9HIVl,|82317077|sp|Q5U940|Q5U940_9HIVl,|82317075|sp|Q5U8J8|Q5U8J8_9HIVl,|82317073|sp|Q5U8I0|Q5U8I0_9HIVl,|82317071 |sp|Q5U8G2|Q5U8G2_9fflVl,|82317069|sp|Q5U8D5|Q5U8D5_9HDYl,|82317067|sp|Q5U8B7]Q5U8B7_9HrVl,|82317063|sp|Q5U890|Q5U890_9HrVl,|82317055|sp|Q5SFQ3|Q5SFQ3_9HIVl,|82315002|sp|Q5QCV0|Q5QCV0_9fflVl,|82315000|sp|Q5QCT2|Q5QCT2_9fflVl,|82314998|sp|Q5QCR4|Q5QCR4_9E0Yl,|82314915 |sp|Q5PYN9|Q5PYN9_9HIVl,|82314715|sp|Q90QP9|Q90QP9_9HIVl,|82314596|sp|Q90MM5|Q90MM5_9HIVl,|82314594|sp|Q90MK7|Q90MK7_9inVl)|82314306|sp|Q90DU3|Q90DU3_9HIVl)|82314188|sp|Q90D17|Q90D17_9EQVl,

|82318410|sp|Q6JMH8|Q6JNH8_9HTVl|82318407|sp|Q6JNG0|Q6JNG0_9fflVl|82318405|sp|Q6JNE2|Q6JNE2_9HIVl|82318403 |sp |Q6 JNB 5 |Q6INB5_9HIV 1|82318401 |sp|Q6JN97|Q6JN97_9HIVl|82318399|sp|Q6JN80|Q6JN80_9HIVl|82317976|sp|Q6HlT8|Q6HlT8_9HTVl|82317974|sp|Q6HlS0|Q6HlS0_9HTVl|82317972|sp|Q6HlQ2|Q6HlQ2_9H3Vl|82317970|sp|Q6HlN4|Q6HlN4_9HIVl|82317953|sp|Q6EG87|Q6EG87_9HIVl|82317949|sp|Q6EG42|Q6EG42_9HIVl|82317945|sp|Q6EFZ7|Q6EFZ7_9HIVl|82317943 |sp|Q6EFX9|Q6EFX9_9HIV 1|82317938|sp|Q6EFN2|Q6EFN2_9mVl|82317782|sp|Q6B4P3|Q6B4P3_9HTVl|82317780|sp|Q69GS3 |Q69GS3_9HTV1|82317778 |sp|Q69GQ5 |Q69GQ5_9HIV1|82317776|sp]Q6SGN7|Q69GN7_9HP/l|82317644|sp|Q673V8|Q673V8_9HIVl|82317642|sp|Q672U5|Q672U5_9HIVl|82317640|sp|Q672S9|Q672S9_9HTVl|82317633|sp|Q66TT6|Q66TT6_9HIVl182317631 |sp|Q66TR8|Q66TR8_9HIVl|82317628|sp|Q66Q72|Q66Q72_9HIVl|82317198|sp|Q5UEH6|Q5UEH6_9HIVl|82317086|sp|Q5U9Cl|Q5U9Cl_9HIVl|82317084|sp]Q5U9A4|Q5U9A4_9HTVl|82317082|sp|Q5U987|Q5U987_9HIVl|82317080|sp|Q5U971 |Q5U971_9HIV1|82317078|sp|Q5U947|Q5U947_9HIVl|82317076|sp|Q5U8K7|Q5U8K7_9HIVl|82317074|sp|Q5U8I9|Q5U8I9_9HIVl|82317072|sp|Q5U8Hl|Q5U8Hl_9HTVl|82317070|sp|Q5U8F3|Q5U8F3_9HTVl|82317068|sp|Q5U8C6|Q5U8C6_9HIVl|82317066|sp|Q5U8A8|Q5U8A8_9HTVl[82317062|sp|Q5U881 |Q5U881_9HIV 1|82315003|sp|Q5QCV9|Q5QCV9_9HIVl|82315001 |sp|Q5QCUl |Q5QCU1_9HIV1|82314999|sp|Q5QCS3|Q5QCS3_9fflVl|82314916|sp|Q5PZV6jQ5PZV6_9HIVl|82314914|sp|Q5PYM6|Q5PYM6_9HIVl|82314714|sp|Q90QP2|Q90QP2_9HIVl|82314595|sp|Q90ML6|Q90ML6_9HIVl|82314307|sp|Q90DZ4|Q90DZ4_9HIVl182314189|sp|Q90D26|Q90D26_9HIVl|82314187|sp|Q90D08|Q90D08_9HIVl1823141 §6|sp|Q90CZ9iQ90CZ9_9HIVl truncada,|823l4184ispjQ90CYl|Q90CYl_9HIVl,|82314182jsptQ90CW4lQ90CW4_9HIVl,|82314166|spjQ90CK8 |Q90CK8_9HIV1,[82314164jsp[Q90CJl |Q90CJl_9HIVl,(82314162|sp|Q90CH5 |Q90CH5_9HIV1,182313942|sp|Q902T5 |Q902T5_9H3V1,|82313940SsplQ902R7|Q902R7_9HIVl,|82313938Ísp|Q902P9]Q902P9_9fflVl,|823I3936|spÍQ902N4|Q902N4_9HrVl5|82313934jsp|Q902L6[Q902L6_9HIVl,182313932fsp |Q902K2|Q902K2_9HIV 1,|82313930|spjQ902I6|Q902I6_9HIVls182313928|sp|Q902G8lQ902G8_9HIVl,|82313925|sp]Q901Z2|Q901Z2_9HIVls]82313923jsp |Q901X4 |Q901X4_9HIV 1,J82313920|sp|Q900Z6]Q900Z6_9ínV 1,(82313641jsp|Q8UPQ7|Q8UPQ7_9HIVl,(82313639|sp jQ8UPPO|Q8UPPO_9HIVl,í$2313ó37jspiQ8TJFM3iQ8U?M3_9HIVl,[82313635|spjQ8UNMl |Q8UNM1_9HIV1,[82313633jsp|Q8UNK3 |Q8UNK3_9HIV 1,t82313584SspiQ8UMF8ÍQ8UMF8_9HIVl}[82313472|sp[Q8QDF7jQ8QDF7_9HlVl,[82313383|sp|Q8Q2F4|Q8Q2F4_9HIVI,[82313374fsp|QSJDM8jQ8JDM8_9HIVl,|82313372|sp|Q8JDMllQ8JDMl_9HIVl,182313370[sp|Q8IDL3 |Q8 JDL39HIV1,|82313368|sp|Q8JDK5lQ8JDK5_9HTVl,182313366|sp |Q8 JD J7JQ8 JD J7_9HIV1,|82313364|sp|Q8JDI9jQ8JDI9_9HIVl,j82313362|sp|Q8JDIl |Q8JDII_9HIV1;182313360|sp |Q8JDH3 |Q8 JDH3_9HIV 1,|82313337|sp]Q$JC64|Q8JC64_9HrVl,|82313335jsp|Q8 JC46 |Q8 JC46_9HlVl,|82313333 |sp]Q8JC28|Q8 JC28_9HIV1,j82313331jsp|Q8 JC10|Q8 JC10_9HIV 1,182313329jsp iQS JB YS[Q8 JB Y8_9HIV1,|82313327|sp|Q8 JBXO|Q8 JBX09HIV1,[82313325jsp | Q8 JB V2 j Q8 JB V2_9HTV1 ?j82313323|sp|Q8 JBT4|Q8JBT4_9HIV 1,J82313321 |sp IQ8 JBR6 [Q 8 JBR6_9HIV 1,|82313319[sp|Q8 JBP8 |Q8 JBP8_9HTV 1,[82313317|sp|Q8JBM7|Q8JBM7_9HIVl,|82313315|sp|Q8JBK91QSJBK9__9HlVI,|82313313|sp|Q8JBJl |Q8JBJ1_9HIV1S|82313311 jsp[Q8JBH3 |Q8JBH3_9HIV1,|82313309|sp|Q8JBP5 |Q8JBF5_9HIV1,

|82314185lsp|Q90CZO|Q90CZ0_9HIVl>|82314183|sp|Q90CX2jQ90CX2_9HIVl)|82314181 |sp!Q90CV5iQ90CV5_9HIVl,(82314l65|sp|Q90CJ9|Q90CJ9_9MVl5182314163[spf Q90CB [Q90CI3 J?HIV 1,l82313943|sp]Q902U4|Q902U4 9HIV1,|82313941|sp |Q902S 6|Q902S6_9HTV 1,|82313939[spSQ902Q8|Q902Q8_9HIVl ?|82313937|sp]Q902P0|Q902P0_9HIV 1,|82313935|sp|Q902M6|Q902M6_9HTVl,|82313933fsp |Q902K7|Q902K7_9HTV 1,|8231393 l)sp|Q902J5|Q902J5_9ínVl>|82313929|sp|Q902H7 (Q902H7_9HIV1,j82313927]sp[Q902Gl |Q902G1„9HIV1,|82313924|sp|Q901Y3|Q901Y3_9inVl,182313922|sp |Q9Q 1W5 JQ901W59HIV1,f82313919lsp|Q900Y7|Q900Y7_9HlVl,|82313640|spSQ8UPP9|Q8UPP9_9HlVÍ,182313638jsp | Q8UPN2|Q8UPN2_9HI VI,18231 3636!sdIOSÜPL4|08UPL4=9HIV1,[82313634]sp[Q8UNL2|Q8UNL2_9HrVl,|S2313585lsp|Q8UMG7|Q8UMG7_9HlVl,|82313581 jsp|Q8UMD6|Q8TJMD6_9HIVl,[82313467]sp|Q8Q7Z2|Q8Q7Z2 9HIV1,[82313382|sp|Q8Q0Y4|Q8Q0Y4_9HTVl,|82313373|sp|Q8JDM4[Q8 JDM4_9HTV1,)S2313371 |sp|Q8 JDL7|Q8 JDL7_9HrVl?|82313369|sp|Q8JDK9jQ8JDK9_9HIVl,|82313367|sp|Q8JDKl jQ8JDKl_9HIVl,|823 i3365|sp|Q8JDJ3|Q8JDJ3_9HÍVl,[82313363]sp |Q8 JDI5 |Q8 JDI5_9HI V1,J82313361 |sp[Q8 JDH7[Q8 JDH7_9IHV1,|82313338[spSQ8JC73|Q8JC73„9HI¥l,|82313336|sp|Q8JC55|Q8JC55_9HIVl>|82313334]sp|Q8JC37|Q8JC37 9HIV1,[82313332|sp |Q8 JC19 |Q8 JC1 99HIV1,|82313330|sp[Q8 JBZ7|Q8 JBZ79HIV1,|82313328|sp|Q8JBX9|Q83BX9_9HIVl,|82313326|5pjQ8JBWl|Q8JBWl_9HIVlí|82313324|sp]Q8JBU3 |Q8JBU3 9HIV1,j82313322|sp|Q8JBS5IQ8JBS5_9mVl,j82313320|sp]Q8 JBQ7 jQ8JBQ7_9HlV 1,|82313318jsp |Q8JBN8 jQ8JBN8_9HIVl,|82313316|sp|Q8JBL8[Q8JBL8_9HIVl3[82313314|sp|Q8JBK0fQ8 JBK0_9HIV1,182313312|splQ8JBI2|Q8JBI2_9HJVl,[82313310]sp[Q8JBG4[Q8JBG4_9HIVl,182313308[sp |Q8 JBB6 [Q8 JBE6_9HIV I,JS2313307}sp|Q8JBD7|Q8JBD7_9lHVl,|823Í3305|sp|Q8;íBB9|Q8JBB9_9HlVl,j823l3303|sp|Q8IBA6|Q8JBA6_9HIVl,]823133O L |sp]Q8 JAXO[Q8 JAX0_9HIV1,|82313289[sp|Q8J9B 1 |Q8J9B1_9HIVI,|82312899jsp|Q8AUI0 |Q8 AUI09HTV1,|82312897|sp|Q8AU79|Q8AU79_9HIVl,f82312895|sp|Q8AU61 |Q8AU61m9HIVl,[82312858jsp |Q8ÁTN3 |Q8ATN3_9HIV 1,|82312852|spiQ8AQV0|Q8AQV0_9HIVl,|82312850[sp]Q8AQT2|Q8AQT2_9HIVl,|82312746|sp|Q8AMN0|Q8AMN0_9Hrvl|82312732|spjQ8AKl 1 (Q8AK11_9HIV1, |82312587jspfQ8AF23fQ8AF23_9HIVl,182312541jspfQS AE76|Q8 AE76j9HIV 1,|82312539fsp|Q8 AE60 |Q8 AE60_9HIVÍ,]82312537|sp[Q8AE44|Q8AE44_9HIVl,J82312535|sp |Q8AB28 |Q8 AE28_9HIV 1,iS23Í2533|spiQ8AElSiQSAEl9_9IilVIíru:|82312531 |sp|Q8AE03 |Q8AE03_9HIV1,|82312529[sp |Q8 ADY7 [Q8 ADY7_9HI Vl,|82312527|sp|Q8ADXl [Q8ADX1_9HIV1,[82312525|sp|Q8 AD V5 [Q8 ADV5_9HIV 1,[82312523|sp|Q8ADT9|Q8ADT9_9HIV 1,[82312521 |spfQ8ADS3[Q8 ADS 3_9HIV1,Í82312519|sp|Q8ADQ7|Q8ADQ7_9HIVl,j82312517|spfQ8 ADP1 |Q8 ADP1 _9HTV 1,[8231251 S|sp[Q8 ADMS ]Q8ADM5_9HTV1,182312513|sp|Q8ADK2]Q8ADK3_9HIVl,[823125 ] 0jsp|Q8ADJ3 |Q8 ADJ3_9HIV1,|82312508Ísp|Q8ADH7|Q8ADH7_9HrviI182312506|sp |Q8 ADGl |Q8ADG1_9HIV1,J82312504jsp |Q8 ADE5|Q8ADB5_9HIV1,|82312502|spjQ8ADC9|Q8ADC9_9HIVl,(823125oojsp |Q8 ADB3 |Q8ADB3_9MV 1,|82312498 [sp|Q8AD97|Q8AD97_9HlVl,)82312496jsp |Q8AD81JQ8 AD81 _9HIV 1,|S2312480|spjQ8ACA9|Q8ACA9„9HlVl,|823l2476[sp|Q8AC75jQ8AC75_9HlVÍ truncada,(82312474|sp]Q8 ACl 8 [Q8AC18_9HIV1 trancada,j82312178|sp|Q7ZMH71Q7ZMH7_9HIVl>[82312176|spjQ7ZMF9|Q7ZMF9_9HlVla[82311989]sp JQ7ZJG3 jQ7ZJG3_9HIV 1,|8231 l987|sp[Q7ZJE8|Q7ZJE8_9HIVl,|82311985|sp[Q7ZJDOlQ7ZJDO_9HrVl,j82311983|spíQ7ZJB3ÍQ7ZJB3_9HrVl,(82311981 jsp[Q7Z JAO[Q7ZIAO_9HIV1,|82311975Ísp|Q7ZGR6]Q7ZGR6_9HIVl,

|82313306|sp |Q8 JBC8 |Q8 JBC8_9HTV1,]82313304|sp [Q8JBB0|Q8 JBB 0_9HTV1,|82313302|sp[Q8JAX8jQ8JAX8_9HIVl,[82313290]sp[Q8 J9CO|Q8 J9C0_9HIVÍ,|82312946|sp|Q8J3U5|Q8J3U5_9HlVl,|823 l2898|sp|Q8AU88|Q8AU88_9HIVl,[8231289ójsp|Q8AU7QjQ8AU70_9fflVl,|82312859[sp|Q8ATN9|Q8 ATN9_9H1V 1,|82312853|sp IQ8 AQV9 |Q8 AQV9_9HIV 1,[82312851 |sp|Q8 AQUI |Q8AQU1_9HIV1,[82312849jsp[Q8 AQS3 |Q8 AQS3_9HIV1,

trancada,

[82312731jsp|Q8AK02|Q8AK02_9fflVl,[82312579]splQ8 AB W6 jQ8 AEW<5_9HIV1,|82312540[sp]Q8AE68|Q8 AE68_9HIV13|82312538|sp|Q8AE52|Q8AE52_9HIVl,|82312536|sp]Q8AE36|Q8AE36_9HIVl,|82312534|sp[Q8 AB24|Q8 AE24_9HIV 1 ,^^i^wjieninRÀTJjiIinRARii 9HTV1.

]82312530|sp|Q8ADZ5|Q8ADZ5_9HIVl 5[8231252S[splQ8 ADX9 |Q8ADX9_9HIV 1,[82312526|sp|Q8ADW3]Q8ADW3_9MVl,]82312524|sp|Q8ADU7|Q8ADU7_9HIVl,[82312522|spjQ8 ADT l [Q8 ADT1_9HIV1,[82312520[sp IQ8ADR5 |Q8 ADR5_9HIV1,|8231251S]sp|Q8 ADP9|Q8 ADP99HIV1,182312516[sp|Q8ADN3|Q8ADN3_9HIVl,|82312514|sp jQ8 ADL7[Q8 ADL7_9HIV 1,(8231251 l|sp]Q8ADKl[Q8ADKl_9HIVl,[82312509]sp|Q8 ADI5|Q8 ADI5_9HTV 1,(82312507|sp|Q8ADG9|Q8ADG9_9HIVl,|82312505|sp |Q8 ADF3[Q8 ADF3_9HTV l,[82312503jsp[Q8ADD7|Q8ADD7_9HlV 1,182312501 |sp|Q8ADCl |Q8ADC1_9HIV1,182312499jsp|Q8ADA5|Q8ADA5_9HIVl,[82312497[sp|Q8AD89|Q8AD89„9HIVl f[82312495|spfQ8AD73 |Q8AD73 9HTV1.,|82312477jsp]Q8AC83|Q8AC83 9HIV1,J82312475jsp |Q8 AC67[Q8AC67_9HIV 1,|82312179|splQ7ZMI6|Q7ZMI6 9HIVI,|82312177|sp[Q7ZMG9[Q7ZMG9 9HIV1,J82311990|spjQ7ZJJ3|Q7ZJJ3 „9HIV1,[82311988|sp]Q7ZXF7|Q7ZJF7_9HÍVlJ|82311986|sp |Q7Z JD9jQ7ZJD9_9HIV 1,S82311984[splQ7ZJC2|Q7ZJC2_9HIVl,|82311982|sp [Q7ZJA5 [Q7Z JA5_9HIV 1,(82311980[sp]Q7ZJ89|Q7ZJ89_9HIVl ,]82311700[sp |Q7ZC22[Q7ZC22_9HIV 1,|82311695|sp|Q7ZBG3|Q7ZBG3_9HIVl,|82311618|sp|Q7SV24|Q7SV24_9mVl,|82311616|sp|Q7SV06|Q7SV06_9HIVl,|82311614|sp|Q7SUZ0|Q7SUZ0_9HIVl,|82311612|sp|Q7SUX2|Q7SUX2_9HrVl,|82311542|sp|Q7SQA9|Q7SQA9_9HIVl,|82311539|sp|Q7SQ50|Q7SQ50_9HIVl,|82311534|sp|Q7SPU4|Q7SPU4_9HIVl,|82311518|sp|Q7SPQ5|Q7SPQ5_9HIVl,|82311422|sp|Q7SKH5|Q7SKH5_9HIVl,|82311420|splQ7SKF7|Q7SKF7_9HIVl,|82311418|sp|Q7SII3|Q7SII3_9HIVl,|82311089|sp|Q75759|Q75759_9HIVl,(82311059|sp|Q74811 |Q74811_9HIV1,|82311049|sp|Q72982|Q72982_9HrVl,|82310923|sp|Q71 AY7|Q71 AY7_9HIV1,|82310921 jsp |Q71AW9 |Q71 AW9_9HIV 1,182310818 |sp|Q6YA59|Q6YA59_9HIVl,|82310814|sp|Q6Y934|Q6Y934_9IflVl,|82310812|sp|Q6Y916|Q6Y916_9HIV1,|82310810|sp|Q6Y8Z8|Q6Y8Z8_9HIVl,|82310807|sp|Q6Y8 Y0|Q6Y8 Y0_9HIV1,|82310805|sp|Q6Y8W2|Q6Y8W2_9HTVl,|82310803 |sp|Q6Y8U4|Q6Y8U4_9fflVl,|82310801 |sp|Q6Y8S7|Q6Y8S7_9HIVl,|82310798|sp|Q6XKC7|Q6XKC7_9HrVl,|82310791 |sp|Q6X6X3|Q6X6X3_9HIVl,j82310789jsp IQ6X6V5 |Q6X6V 5_9HIV 1,|82310786|sp|Q6X6T8|Q6X6T8_9HIVl,|82310784|sp|Q6X6S0|Q6X6S0_9HIVl5|82310780|sp|Q6X6Q4|Q6X6Q4_9HIVl,|82310778|sp|Q6X6N6|Q6X6N6_9HIVl,|82310774|sp|Q6X6L9|Q6X6L9_9HQYl,|82310772|sp|Q6X6Kl |Q6X6K1_9HTV1,|82310768|sp|Q6X6I6|Q6X6I6_9HIVl,|82310764|sp|Q6X6G9|Q6X6G9_9HIVl3|82310656|sp|Q6V3T5|Q6V3T5_9HIVl,|82310617|sp|Q6UFQ7|Q6UFQ7_9HIVl,|82310615|sp|Q6UFN9|Q6UFN9_9HIVl,|82310613|sp|Q6UFM2|Q6UFM2_9HIVl,18231061 l|sp|Q6UFK7|Q6UFK7_9HIVl,|82310609|sp|Q6UFI9|Q6UFI9_9HIVl,[82310607|sp|Q6UFHl |Q6UFH1_9HIV1,|82310605|sp|Q6UFF3 |Q6UFF3_9HIV1,|82310603|sp|Q6UFD9|Q6UFD9_9HIVl,j82310601 jsp |Q6T_JFC5 |Q6UFC5_9HIV 1,|82310599|sp|Q6UFA7|Q6XJFA7_9EHVl,|82310597jsp|Q6UF89|Q6UF89_9HIVl,

|82311619|sp|Q7SV40|Q7SV40_9HIVl,|82311617|sp|Q7SV15|Q7SV15_9HIVl,|82311615|sp|Q7SUZ7|Q7SUZ7_9HTVl,|82311613 |sp|Q7SUYl |Q7SUY1_9HIV1,|82311606|sp|Q7SQN0ÍQ7SQN0_9HIVl,|82311541|spjQ7SQA4|Q7SQA4_9fflVl,|82311538|sp|Q7SQ41|Q7SQ41_9fflVl,|82311533|sp|Q7SPT4|Q7SPT4_9HIVl,|82311515|sp|Q7SPP9|Q7SPP9_9HTVl,|82311421 |sp|Q7SKG6|Q7SKG6_9HIVls|82311419|sp|Q7SU3 |Q7SLJ3_9HrV 1,|82311201|sp|Q76PP8|Q76PP8_9HTVl,|82311060|sp|Q74839|Q74839_9HIVl,Í82311050jsp|Q7299lÍQ72991_9HIVl,j82310929jsp|Q72501 ÍQ72501_9HIV1,|82310922|sp|Q71AX8|Q71AX8_9HIVl5|82310902|sp|Q71817|Q71817_9HTVl,|82310815 |sp|Q6Y943 |Q6Y943_9HIV1,j82310813 jsp jQ6Y925 jQ6Y925_9KTv 1,|82310811 |sp|Q6Y907|Q6Y907_9HIVl,|82310808|sp|Q6Y8Y9|Q6Y8Y9_9HTVl,|82310806|sp|Q6Y8Xl |Q6Y8Xl_9fflVl5j82310804|sp jQ6Y8V3 |Q6Y8V3_9HIV1,|82310802|sp|Q6Y8T6|Q6Y8T6_9HIVl,|82310800|sp|Q6Y8R8|Q6Y8R8_9HTVl,|82310797|sp|Q6XKB8|Q6XKB8_9HIVl,|82310790|sp|Q6X6W4|Q6X6W4_9HTV 1,|82310787|sp|Q6X6U7|Q6X6U7_9HIVl,]82310785|sp|Q6X6S9|Q6X6S9_9HTVl,|82310783 |sp|Q6X6R3 |Q6X6R3_9HIV1,|82310779|sp|Q6X6P5 |Q6X6P5_9HIV1,|82310777|sp|Q6X6M8|Q6X6M8_9HIVl,|82310773|sp|Q6X6L0|Q6X6L0_9HIVl,(82310771 |sp|Q6X6 J4|Q6X6 J4_9HIV1,|82310767|sp|Q6X6H7|Q6X6H7_9HTVl,|82310747|sp|Q6WS71|Q6WS71_9HIVl,|82310655|sp|Q6V3S7|Q6V3S7_9HIVl,|82310616|sp|Q6UFP8 |Q6UFP8_9HIV1,|82310614|sp|Q6UFN0|Q6UFN0_9HIVl,|82310612|sp IQ6UFL5 |Q6UFL5_9HIV 1,|82310610|sp |Q6UFJ8 |Q6UFJ8_9HIV1,]82310608|sp|Q6UFI0|Q6UFI0_9HIVl,|82310606|sp|Q6UFG2|Q6UFG2_9HIVl,|82310604|sp|Q6UFE5|Q6UFE5_9HIVl,|82310602|sp|Q6UFD4|Q6UFD4_9HIVl,|82310600|sp |Q6UFB6|Q6UFB6_9HTV 1,|82310598|sp|Q6UF98|Q6lIF98_9HIVl,|82310596|sp|Q6UF80|Q6UF80_9HrVl,|82310595|sp]Q6UF72|Q6UF72_9HTVl,|823 l0593|spiQ6ÜF58[Q6UF58„9inVl,182310591|spJQ6UF40|Q6UF40_9HTVL,JS2.3 l0589|sp|Q6UF22|Q6UF22_9HIVl>{823 l0587|spÍQ6UF06|Q5UF06„9HrVl,(82310585|sp|Q6UEY9|Q6UEY9_9HlV 1,}82310583|spÍQ6UEXl!Q6UEXl_9fflVl,Í82310581|spSQ6UEV3 |Q6UEV3_9HIV1,[823Í0579|sp|Q6UET5|Q6UET5 9HIV1,|82310577jsp|Q6UER8[Q6UER8_9HIVis|S2310575|sp|Q6UEQO[Q6UEQO_9HIVl,|S2310573|sp|Q6UEN3|Q6UEN3_9HIVl,182310571 |sp|Q6UEK9|Q6UEK9_9HIVl,j82310468[sp|Q6S887|Q6S887_9HIV 1,]823l0466|spjQ6S863|Q6S863_9HIVl,182310464|sp|Q6S846|Q6S846_9HTV 1,|823 l0462|spiQ6S831|Q6S831_9HIVl,|82310460|spjQ6S815 |Q6S 815_9HIV1,(82310458jsplQ6S7Z9|Q6S7Z9_9HIVl,[8231045Õ jsp[QõS7Y3 jQóS 7 Υ3_9Κιν I,|82310454|$p|Q6S7W5|Q6S7W5_9HIVl,|82310452Jsp|Q6S7U9|Q6S7U9_9HIVl,[82310450|sp|Q6S7T2|Q6S7T2_9HIVl>182310411jsp[Q6RJG0|Q6RJ G09HTV1,j82310404[sp |Q6RJD2|Q6RJD2m9HIV I,182310399|sp|Q6RJB 1 |Q6RJB 1_9HTV 1,182310392[sp|Q6RJ76|Q6RJ7ó_9HIV 1,|82310387|sp|Q6RJ62jQ6RJ62 9HIV1,|82310039|sp]Q6QKYl|Q6QKYl_9inVl,l82309906|spjQ<SQ462|Q6Q462_9HIVl5|82309904|sp|Q6Q436jQ6Q436_9HIVl,|823099O2[sp|Q6Q2VO|Q6Q2V()_9HIVl,l82309890|sp|Q6PR19)Q6PR19_9HIVls|82309887|sp|Q6PR04|Q6PR04 9HIVlmutante|82309884|sp|Q5MJ74fQ5 MJ74__9HIV 1,]82309832|sp|Q5MH05jQ5MH05_9fflVl,l82309826|sptQ5MGY7|Q5MGY7 9HTV1,|82309820|spjQ5MGW9 [Q5MGW9_9HTV 1,|82309812jsp| Q5MGT81 Q5MGT89HÍV 1,(82309772jsp| Q5G7E4]Q5 G7E4_9HIV 1,(82309769jsp| Q5G7B8|Q5 G7B8_9HIV1,[82309754jsp|Q5FY40jQ5FY40_9HIV 1,[82309752|sp|Q5FY22|Q5FY22_9HIVl,|82309750[sp|Q5FY04]Q5FY04_9HIVl,|82309748[sp 1QSFXY6 [Q5FXY6_9HIV1,|82309746[sp|Q5FXW8|Q5FXW8_9HIVl,|82309744|spjQ5FXV0|Q5FXV0_9HrVl,i82309742|sp|Q5FXS4|Q5FXS4_9HIVl,

|82310594|sp]Q6UF65 jQ6UF65_9HIVl ,|82310592]sp|Q6UF49|Q6UF49 9HIV1,|82310590]sp[Q6tJF31 |Q6UF31_9HIV1}[82310588|sp[Q6UFl 3 |Q6UF 13_9fflV 1,[82310586|sp]Q6UEZ8]Q6UEZ8_9HIVl,|82310584jsp|Q6ÜBY0|Q6UEY0_9inVl,|82310582|sp jQ6UE W2|Q6UEW2_9H1V1,|82310580jsp|Q6UEU4 |Q6UEU4_9HIV1,|82310578|spíQ6UES6|Q6UES6_9HIVl,[82310576[sp|Q6UEQ9|Q6UBQ9_9HIVl,|82310574|sp[Q6UBP2]Q6UEP2_9fnVl,|82310572jsp [Q6TJEL8 |Q6ÜEL8__9HIV 1,|82310570|sp|Q6UEK0|Q6UEIC0_9HIVl3182310467[$p [Q6S878[Q6S878_9HIV 1,|82310465|sp|Q6S854|Q6S854_9HIVl,|82310463jsp IQ6S838|Q6S838 9HTV1,|82310461|sp|Q6S824|Q6S824_9HrVlJ|82310459|splQ6S807|Q6S807_9HIVl,[823l0457|sp|Q6S7Z2|Q6S7Z2_9HIVl,

[82310453|sp[Q6S7V8|Q6S7V8~9HIVl,[82310451 [sp|Q6S7Ul |Q6S7U1_9HIV1,|823 l0449|splQ6S7S4|Q6S7S4_9HlVl,|8231040S|sp[Q6RJE6|Q6RJE6_9HIVl,|82310402jsp|Q6RJC5jQ6RJC5_9HIVl,|S2310394[sp|Q6RJ833Q6RJ83_9HEVl,[82310389|spjQ6RJ69[Q6RJ69_9HIV 1,|82310382|sp|Q6RFP3|Q6RFP3_9HIVl,|82310038[sp|Q6QKX2[Q6QKX2 9HIV1,[82309905|sp[Q6Q453[Q6Q453_9HIV 1,|82309903|sp|Q6Q2V9|Q6Q2V9_9HIVl,[82309891 [sp|Q6PR27[Q6PR27_9HlVl>|82309889[sp|Q6PRlI[Q6PRll_9HIVlmutaiite,1823098861sp!Q6PQZ6iQ6PQZ6_9HIV 1,|82309835jsp|Q5MH 14|Q5MH 14_9HTV1,|82309829|sp|Q5MGZ6|Q5MGZ6_9HTVl,]82309823|sp|Q5MGX8|Q5MGX8_9HTVl,S82309817jsp]Q5MGWl |Q5MGW1_9HIV1,(82309773[sp |Q5G7F3|Q5G7F3 9HTV1,j82309770|sp IQ5G7C7 |Q5G7C7_9HIV 1,182309768|sp|Q5 G7A9[Q5G7A9_9HIV1,|82309753|sp|Q5FY31 |Q5FY31_9HIV1,182309751 |sp|Q5FY 13 (Q5FY139HIV1,|82309749|sp|Q5FXZ5|Q5FXZ5_9HIVl)|82309747|sp|Q5FXX7|Q5FXX7_9HlV 1,|82309745jsp[Q5FXV9|Q5FXV9_9HIVl,|82309743|sp|Q5FXT3|Q5FXT3_9HIVl>[82309741 |sp|Q5FXR5!Q5FXR5_9HlVl,|82309740]sp|Q5FXQ8fQ5FXQS_9HIVl,|82309738jsp|Q5FXPOjQ5FXPO_9HIVl,(82309556jsp IQ5EB J21 Q5BEJ2_9HIV L,[82309554|sp|Q5EEH4|Q5EEH4_9HIVl,|82309552|sp |Q5EBF7|Q5EBF7_9HIV 1,|82309550|sp|Q5EED9|Q5EED9_9EQVl,|82309548|sp|Q5EEC2tQ5EEC2_9HIVl,|82309546| sp |Q5BBÀ4)Q5EEA4_9HIV I,|82309544| sp|Q5EE8 8 jQ5EE8 8_9HIV 1,|82309542jsp|Q5EE72|Q5EE72_9HIV 1,|82309540|sp|Q5EE5 6|Q5EE56_9HIV 1,182309380|sp]Q5 C9X6 |Q5C9X6 9HTV1,j82309217| sp|P87922|P87922_9H3V I,182309193 jsp j092S96 |092896_9HIV 1,|$2309191|spl092886|092886_9HrVl,|82309Í7l|spj092298|092298_9EUYl,|82309126|sp|090594|090594_9HIVl)J82309096|sp|071268j071268_9HIVl,182308901 |sp|040220|040220_9HIY 1,|82308768|sp|Q56CX3 ]Q5 6CX39HIV1,|78172859|gbjABB29390.1|, |78172849|gb|ABB29381.1|,|78172829|gb j ABB29363.1|f163081182|gb|AAY30344. ![truncada,

!55275251 jgb | AAV49464.11,|55275221 |gb|AAV49437.1 j,[55275191 |gbjAAV49410. 11,[55275161 jgb]AAV49383.1[55275131 jgbj AAV49356.1 j,[73913980|gbj AAZ91942,11,173913936|gb[ AAZ91903.1[73913907(gb j AAZ91877.1j,|73913878jgbj AAZ91851.11,|73913848Ígb|AAZ91824.1 j,[73913818|gb}AAZ91797.lÍ|73913789|gb[AAZ91771.1173913759| gb j AAZ91744.1137681536| gb j AAQ97646,11,j37677899|gbjAAQ97565,l],|37677S69[gb|AAQ97538J],|37677839|gb|AAQ97511.1j,|37677809|gb|AAQ97484.1]?|37677779|gb[AAQ97457.1j,[62361777|gb|AAX81425, lj,|71794608jembJC AI28849.1|,l71794580jemblCAI28822.ll,[57901095[gb | AAW57861.1],|57901063jgb j AAW57832.1j,|58221022jgb j AAW6S198-1 j»

155275241 [gbjAAV49455.ll,(55275211 [gbÍAAV49428.1j,]55275181 |gb|AAV49401.1],[55275151 |gb|AAV49374. lj,[55275121 |gb[AAV49347.1 [,[73913970|gb[AAZ91933.1],|73913926|gb[AAZ91894. lj,l73913897jgblAAZ91868.il,173913 868jgbj AAZ91842.1|,|73913838|gb[AAZ91815.1|,173913808|gb[ AAZ91788.11,[73913779|gbjAAZ91762.11,146243169|gb|AAS83695.1j,|37681546|gb|AAQ97655.1[,|37677889|gb[AAQ97556.1 j,|37677859;|gb|AAQ97529.1[,|37677829|gb|AAQ97502.1 [,|37677799|gb|AAQ97475.11,|37677769]gb|AAQ97448.11,|71794628| erab [C AI28867.11,|71794599|emb|CAI28840.1|,J57901114|gb|AAW57878.11,|57901086]gb|AAW57853.1(,|58221042|gb| AAW68216.1[,|58221012|gb[AAW68189.1[,

|82309739[sp|Q5FXP9|Q5FXP9_9HIVl|82309737[sp|Q5PXNl[Q5FXNl_9HIVl|82309555|sp|Q5 ΕΕΙ3 |Q5EEI3_9HIV1[82309553[sp|Q5EEG6|Q5BEG6_9HIVl|82309551|sp|Q5EEE8iQ5EEE8_9HIVl|82309549|sp|Q5EEDl |Q5EED1 9HIV1]82309547|sp]Q5EEB3|Q5EEB3 9HIV1|82309545|sp[Q5EE96|Q5EB96_9HIV 1j82309543lspjQ5EE79jQ5EB79_9HIVlj823095411spjQ5BE64jQ5EE64_9HIVl|82309383|sp]Q5C9Y5 [Q5C9 Y59HIV1|82309244|sp[P90241 |P90241_9HIV1|82309198[sp|093023]093023 9HIV1j82309192jspÍ092889Í092889_9HlVl|82309190jsp j092881j092881_9HEV 1|82309128jsp j090597]090597_9HIV Ij82309097jsp j071278]071278_9ETV 1|82308946Íspj042063i042063_9HIVl[82308772|sp[Q56CX7|Q56CX7_9HIVl|82282692jsp [Q5FXU1 jQ5FXÜI_9HTv 1|78172839|gb[ABB29372.1|178172821 |gb|ABB29356.11155275261 |gb[AAV49473.11[55275231 |gb|AÀV49446.1 j[55275201 |gb|AAV49419.11[55275171 jgb[AAV49392.11|55275141 |gbfAAV49365.11]73913998jgb|AAZ91958.1l73913945jgbjAAZ91911.11j7391391 ójgb j AAZ91885.11|739l3887|gb[AAZ91859,l|Í7391385S|gb|AAZ9l833jjj73913828lgb|AAZ91806.11|73913799[gb | AAZ91780.1]|73913769|gb|AAZ91753.1[46243161 |gb] AAS83688.11|37677909|gb|AAQ97574. lj|37677S79jgb|AAQ97547.1]|37677849|gb|AAQ97520.1|137677819|gb|AAQ97493.11|37677789]gb|AAQ97466.1||37677759jgb|AAQ97439.11171794618|emb|CAI28858.lj|71794590jembjCAI2S831.1|57901102]gb|AAW57867.1 [|57901073[gb|AAW57841.11|58221032]gb| AAW68207.11|58221004]gb j AAW68182.1 j|58220994|gb|AAW68173.1

|58220965|gb|AAW68147.1

|58220935|gb|AAW68120.1

|58220905|gb|AAW68093.1

|58220875|gb|AAW68066.1

|38892778|gb|AAR27769.1

|38892749|gb|AAR27743.1

|3889272 l|gb|AAR27718.1

|38892694|gb|AAR27694.1

|38892667|gb|AAR27670.1

|3 8892641 ]gb|AAR27647.1

|38892604|gb|AAR27614.1

|55139334|gb|AAV41349.1

|55139304|gb|AAV41323.1

|55139275|gb|AAV41297.1

|68522158|gb|AAY98743.1

|68522129|gb|AAY98717.1

)68522099|gb|AAY98690.1

|68522069|gb|AAY98663.1

|68522039|gb|AAY98636.1

|68522009|gb|AAY98609.1

|68521979|gb|AAY98582.1

|68521949|gb|AAY98555.1

|67553106|gb|AAY68692.1

|67553076|gb|AAY68665.1

|67553046|gb|AAY68638.1

|67553019|gb|AAY68614.1

167552991 |gb|AAY68589.1

|63098425 |gb|AAY32464.1

|63098395|gb|AAY32437.1

|63098367|gb|AAY32412.1

|63098338|gb|AAY32386.1

|63098309|gb|AAY32360.1

|56609346|gb|AAW03296.1

|56609309|gb|AAW03264.1

|56609279|gb|AAW03237.1

|56609249|gb|AAW03210.1

|32399670|emb|CAD58648.

118073419|emb|CAC88009.

j 140416411emb |C AC38425.

|9368374|emb|CAB98191.1

17630101 |emb|CAB53047.2

|7321149|emb|CAB82231.1

|59003672|gb|AAW83667.1

|59003642|gb|AAW83640.1

|59003613|gb|AAW83614.1

|59003583|gb|AAW83587.1

|59003553|gb|AAW83560.1

|58220984|gb|AAW68164.1|,|58220955|gb|AAW68138.1|,|58220925|gb|AAW68111.1 j,|58220895|gb|AAW68084.1|,l58220865|gb|AAW68057.1|,|3 8892768 |gb|AAR27760.11,|38892741 |gb|AAR27736.11,|3889271 l|gb|AAR27709.1|,|38892685|gb|AAR27686.1|,|38892659|gb|AAR27663.1|,|38892631 |gb|AAR27638.1 j,|55139354|gb|AAV41367.1|,|55139325|gb|AAV41341.1|,|55139295|gb|AAV41315.1|,l55139266lgblAAV41289.ll,|68522149jgb|AAY98735.1|,|68522119|gb|AAY98708.1|,|68522089]gbjAAY98681.1 j,|68522059|gbjAAY98654.1j3|68522029|gb|AAY98627.1|sl68521999lgblAAY98600.ll,|68521969|gb|AAY98573.1|,|68521939|gb|AAY98546.1|,|67553096|gb|AAY68683.1|,|67553066|gb|AAY68656.1|,|67553036|gb|AAY68629.11,|67553010|gb|AAY68606.1|,|67552981 |gb|AAY68580.11,|63098415|gb|AAY32455.1|,|63098385|gb|AAY32428.1|,|63098357|gbjAAY32403.1|s|63098328|gb|AAY32377.1|,|63098300|gb|AAY32352.11,|56609335|gb|AAW03287.1|,Í56609299|gb|AAW03255.1|,|56609269|gb|AAW03228.1|,|60197|emb|CAA77626.11,, |32399661|emb|CAD58639.1|,, 118073409|emb|CAC8 8000.11,, 114041631 |emb|CAC38434.11,|8920157|emb|CAB96343.1|,|7452914|emb|CAB86379.1|,|7321139|emb|CAB82222.1|,|59003662|gb|AAW83658.1|,|59003632|gb|AAW83631.11,|59003603|gb|AAW83605.1|,|59003 573 |gb|AAW83578.1 ],|59003 543 |gb|AAW83551.11,

|58220975|gb|AAW68156.1|58220945|gb|AAW68129.1|58220915|gb|AAW68102.1|58220885|gb|AAW68075.1||38892787|gb|AAR27777.1 ]|38892759|gb|AAR27752.1j|3889273 l|gb|AAR27727.1 j|38892703|gb|AAR27702.1||38892675jgbj AAR27677.11|3 8892650|gb|AAR27655.1 j|38892614|gb|AAR27623.1||55139345|gb|AAV41359.lj|55139313|gbÍAAV41331.1||55139284|gb|AAV41305.1|55139257|gb|AAV41281.1||68522139|gb|AAY98726.11|68522109|gb|AAY98699.1 j|68522079|gb|AAY98672.11i68522049jgbjAAY98645.1j|68522019|gb|AAY98618.1||68521989|gb|AAY98591.lj|68521959|gb|AAY98564.1||67553116|gb|AAY68701.1||67553086|gb|AAY68674.1||67553056|gb|AAY68647.1 j|67553026|gb|AAY68620.1]167553001 |gb|AAY68598.11|63098435|gb|AAY32473.1||63098405|gb|AAY32446.11|63098376|gb|AAY32420.11|63098348|gb|AAY32395.1||63098318|gb|AAY32368.1 j|63098290|gb|AAY32343.1 j|56609319|gb|AAW03273.11|56609289|gb|AAW03246.1||56609259|gb|AAW03219.1||3163935|emb|CAA06951.1||18074004|emb|CAC86569.11115209260|embjCAC51039.1 j|9368384|emb|CAB98173.11|7657894|emb|CAB89148.1||7452904|emb|CAB86370.1||4539039|emb |CAB39921.11|59003652|gb|AAW83649.11|59003623|gb|AAW83623.1||59003593|gb|AAW83596.1||59003563|gb|AAW83569.1||59003533|gb|AAW83542.1||59003523|gb|AAW83533.1|, |59003513|gb|AAW83524.1[,145738217|gb|AAS75876.11, |38326777|gb|AAR17519.1|,

155925132|gbfAAV67937.11,[5 1572131 |gb|AAU06778. Ij5)51572099|gb[AAU06749.lj,[49472945|gb[AAT66288.1),|37682604|gb[AAQ9S284.1|,|37682574|gb(AAQ98257.11,l37682545jgblAAQ98231.il,|37682515|gb|AAQ98204.1 [,|37682486|gb| AAQ98178.1 [,j376824561gblAAQ98151.1|,]37682426|gb|AAQ98124 1|,)46486668|gb|AAS9877M

|55925124|gb[AAV67930.1|,(51572121|gb[A AU06769.11,|47060061|gblAAT09647.1 j,|49472936|gb|AAT6628Q.1 |,|37682594[gbfAAQ98275.1|,|37682565[gb|AAQ98249.1Í37682535|gb|AAQ98222.1],[376S2505|gb|A AQ98195. l[,|37682476|gb] AAQ98169.1|,|37682446|gb) AAQ98142.11,

|45738227|gb| AAS75885.1J55925140|gbfAAV67944.1[,J55925116|gb[AAV67923.1[,[51572112|gb)AAUG6761.11,|49472954|gb|AAT66296.1[,|49472927jgb | AAT66272.1|37682584|gb | AAQ98266.1|37682555|gb|AAQ98240,l |,j37682525jgbj AAQ98213.1 j,|37682495|gb|AAQ98186.1 j,|37682466|gb|AAQ98160.1j,

l376824365gblAAQ98133.il,137682415|gb|AAQ98114.11 truncada ,|46486659|gb|AAS98763„1 jmutante,[46486651 jgbjAAS98756.1 jmutante, |46486641]gb|AAS98747.1 [, |46486631 |gb|AAS98738.1 f,|46254445]gb| AAS86195.1[46254421|gb|AAS86179.11, |46254411 |gb|AAS86170.1|,

(38679154lgbIAAE26407.il,132261275|gb] AAP74175,1 j,[31980441[dbj [BAC77760.11.|3198041 l'|dbj'|BAC77733. lj,|31559675jdbj |B AC77498.1 [,|31559647[dbj jB AC77473.1 [,

[38679163jgb j AAR26415.11,|32261286|gb j AAP74185,1r-so-í^i ι nsrrrt^i Δ. Δ ΡΙ λ Ι Ι

[31980421|dbj|BAC77742.1|,[31559685[dbj |Β AC77507.11,31559657|dbj |Β AC77482.11.|31559619|dbj|BAC77448.1|,1548725|sp|P35960|RE V_HV 1Υ2,1132424|sp[P19547(REV_HV IS3,1132418|sp(P05864JRE V_H V1B8,1132414jsp[P04325jREV_HVl 12,|62288904|sp|P69718jEEV_HVlH3,|135Ü575|sp|P18803|REV_HVlND,1132435|sp|P05872|REV_HV1 SCi1132431 |sp |P04ó22fREV_HVlMA,1132427jsp|P12485|REV_HVIBN,1132422]sp|P20869|REV_HVl JR,1132419|sp |P04623|REV_HV 1A2,)132416)sp|P05869|REVJHVlZ8,Íl32434lspÍP05870[RBV_HVlRH,1132426|sp [P05868|pREV_HV IZH,j10436176|gb| AAGl6850.11,110436145fgb|AAGl6823.1|,110436117(gb| A AGl6798. l\,[326677jgb| AAA44323.1),[328553|gb[AAB59871.11,|82313506|sp|Q8QDN6fQ8QDN6_9PLVG,[82308871 jspjoi 1406|011406_9PLVG,110180809|gb|AAGl4294.1 [AF251194„2,|62362853|gb|AAX8173Ll|, |62362851|gb|AAX81730.1|, l62362849|gb|AAX81729.1),|62362847|gb|AAX81728.1), [62362845[gb|AAX81727.1), (62362843[gb|AAX81726.1|,162362841 jgb|AAX81725.1|, |62362839[gb]AAX81724.1), Í62362837|gb|AAX8l723.1[,

10436164|gb|AAG16840.11,10436136)gb[AAGl 6815.1j,110436107jgb j AAGl6789.1 [,f329364|gb|AABl2992.1|,|327468[gb|AAA44659.11,

119072109)dbj |B AB85756.11,|32261264[gb|AAP74l65.1[,13198043 l|dbi|BAC77751. 1S,j31559695[dbj jBAC77516.1 [,|31559667|dbj|BAC77491.1 j,|31559637|dbj]BAC77464.1 j,132438[sp [P0461 SjlUsVJBfV 1H2,1132425|sp|P19548|REV_HVlS 1,1132437jsp |P05866|RE V_HV 1W2,j132420[sp ]P04620)RB V_HV IBRj)62288905|sp|P69719|REV_HVlPV,|3024538|sp[Q70624[REV_HV 1LW,1132439[sp [P04619|REV_HV 1Z6,1132432[sp|P20 887JRE V_HV 1OY,1132428|sp|P12484|REV_HV 1J3,1132423[sp [P04621ptE V_HV 1 EL,1132421|sp|P05865pREV_HV 1C4,[132417|sp|P12483[REV HV1Z2,1132413[sp |P04616|RE V_HV IB1,[132430|sp[P05871 |REV_HV1MN,ll32415|sp|P05867[REV_HVlZ3,[10436155|gb|AAGl6832.11,110436126jgb | AAGl6806.11,[221476|dbj|B AA00997.11,|326466|gb | AAA44310.11,|4262344|gb|AAD14580.1|,|82311278isp)Q77MH4)Q77MH4_9PLVG,18766388|gb] AÁL78994.1 |AF465242_6,|2895571 |gb[AAD12140.11,|62362835|gb|AAX81722.1 ],|62362829|gb|AAX81719.1|,|62362823jgblAAX81716.1|5|62362817|gb|AAX81713. lj,|62362811 |gb|AAX81710.11,|62362805|gb|AAX81707.1|,|62362799|gb| AAX81704.11,|62362793 jgbj AAX81701.1 j,|62362787|gb|AAX81698.11,|62362781 |gb|AAX81695.1 j,|62362775|gb|AAX81692.1|,l62362769lgbjAAX81689.il,Í62362763jgbjAAX81686.1 j,Í62362757jgb jAAX81683.1 j,162362751 jgbjAAX81680.1 j,Í62362745jgb j AAX81677.11,|62362739|gbÍAAX81674.1 j,

|62362833lgb| AAX81721.11,jó2362827jgb j AAX81718.1 j,Í6236282ljgb|AAX81715.lj,|62362815|gb|AAX81712.1|,l62362809lgblAAX81709.ll,|62362803|gbjAAX81706.1|,|62362797|gb|AAX81703.11,|62362791 |gb|AAX81700.11,|62362785|gb|AAX81697.11,|62362779|gb|AAX81694.11,|62362773 jgb | AAX81691.11,j62362767Ígb|AAX81688.1 j,Í6236276ljgbjAAX81685.lj,Í62362755|gbjAAX81682.lj,Í62362749ÍgbjAAX81679.lj,|62362743|gb|AAX81676.11,j62362737jgb|AAX81673.1 j,

|62362831 |gb|AAX81720.11,jó2362825jgb jAAX81717.1 j,Í62362819ÍgbÍAAX81714.1|,jó2362813 jgb jAAX81711.1 j,|62362807jgb|AAX81708.lj,Í6236280ljgbÍAAX81705.1|,Í62362795jgbjAAX81702.1 j,Í62362789jgb|AAX81699.lj,j62362783|gbjAAX81696.lj,Í62362777jgb jAAX81693.1 j,|62362771 |gb|AAX81690.1 j,j62362765jgb|AAX81687.lj,Í62362759jgbjAAX81684.1 j,j62362753|gbjAAX81681.lj,jô2362747jgb jAAX81678.11,j6236274ljgb|AAX81675.lj,Í62362735jgb|AAX81672.1 j,

162362733 |gb|AAX81671.1), |62362731 |gb|AAX81670.11, |62362729|gb|AAX81669.11,

!623 62723 Igb1AAXS 1666.1

i»-r/*\ Í-tI xrn 1 /-/O 1 I

|0ZJ0Z/Z/|g0|AAA.01000.1|,

Í62362721 jgb jAAX81665.1 j,Í62362715 |gb|AAX81662.1 j,\62362709jgb|AAX81659.1 j,jó2362703 jgb j AAX81656.1 j,Í62362697|gbjAAX81653.1 j,Í62362691 |gb|AAX81650.1 j,|62362685|gb|AAX81647.1 j,|62362679|gb|AAX81644.1 j,(62362673 |gb jAAX81641.1 j,Í62362667jgbjAAX8l638.lj,Í62362661 |gbjAAX8163 5.1 j,|62362655jgbjAAX8l632.lj,|62362649jgb| AAX81629.1 j,\62362643jgb j AAX81626.1 j,j62362637Ígb|AAX8l623.l|,Í62362631 jgbj AAX81620.11,|62362624|gb|AAX8l6l7.l],|623626l6|gb|AAX8l614.l|,j623626l0|gbjAAX8l6ll.lj,Í62362604jgb|AAX81608.11,|62362598jgbjAAX8l605.lj,Í62362590|gb| AAX81601.11,j18699192|gbjAAL78452.11AF413987_7,|37725242|gb|AAR02305.l|, |37725232|gb|AAR02296.l|,|377252l2|gb|AAR02278.l|, j37725202ÍgbjAA]R02269.lj,Í27227856|dbj|BAC45029.l|, |27227846|dbj|BAC45020.l|,Í326387|gb|AAA44200.l|,Í823l88l6|sp|Q9DH39|Q9DH39_9HIVl,|82318814jsp jQ9DGZ4|Q9DGZ4_9HIVl,

ΚΛΟ/ΟΤΛΠΑΙΑ AV01/C/C7 1l

Í62362719jgbÍAAX81664.lj,Í62362713 |gb|AAX81661.11,|62362707|gb|AAX81658.lj,jó2362701 jgb jA AX81655.1 j,Í62362695jgbj AAX81652.1 j,Í62362689jgbjAAX81649.1 j,Í62362683 jgb|AAX81646.11,|62362677|gb|AAX81643.1|,Í62362671 jgbjAAX81640.1 j,jó2362665jgb j AAX81637.1 j,Í62362659jgb|AAX81634.1 j,Í62362653 jgb j AAX81631.1],|62362647jgb|AAX81628.1 j,Í62362641 jgbjAAX81625.1 j,j62362635 jgb j AAX81622.1 j,|62362629jgbjAAX81619.1 j,|62362622jgb|AAX81616.1|,Í62362614jgbjAAX81613.lj,j62362608jgbÍAAX81610.lj,jô2362602jgb ÍAAX81607.1 j,Í62362594Ígb|AAX81603.lj,

|62362717|gb|AAX81663.11,|62362711 |gbjAAX81660.11,Í62362705 jgbjAAX81657.11,Í62362699jgbjAAX81654.1 j,Í62362693 jgbjAAX81651.1 j,j62362687jgbjAAX81648.1 j,|62362681 |gbjAAX81645.11,|62362675 |gbjAAX81642.11,Í62362669jgb jAAX81639.1 j,Í62362663 jgbjAAX81636.1 j,|62362657ÍgbjAAX81633.1|,|62362651 jgbjAAX81630.11,jó2362645jgb j AAX81627.1 j,jõ2362639jgb j AAX81624.11,|62362633 jgbjAAX81621.11,j62362626Ígb|AAX81618.1|,|62362620|gb | AAX81615.1],|62362612|gb| AAX81612.1 j,Í62362606jgbÍAAX81609.lj,j62362600jgb|AAX81606.1 j,j62362592|gb jAAX81602.11,|18699254|gb|AAL78495.1|AF414006_7,|37725252|gb|AAR02314.1|,j37725222jgbjAARO2287.ll,Í37725196jgb|AAR02264.1 j,|328417|gb|AAA44986.lj,|16118323|gb|AAL12696.1|,|82318815|sp|Q9DH16|Q9DH16_9HIVl,|82318813 |sp|Q9DGW4|Q9DGW4_9HIVl,82312479|sp|Q8ACA0|Q8ACA0_9fflVl,82311318|sp|Q78232|Q78232_9HIVl,

40021891 |gb|AAR37201.140021861|gb|AAR37180.140021831|gb|AAR37159.140021801|gb|AAR37138.140021771 jgbj AAR3 7117.140021741 |gb|AAR37096.14002171 ljgb|AAR37075.14205062|gb|AAD10934.1|,4205035lgblAAD10910.ll,4205008lgblAAD10886.ll,328660|gb|AAB59880.132778 l|gb|AAB03525.1329391 |gb|AAA45375.1328567|gb|AAA45051.1328032|gb|AAA44852.182320737|sp|Q52S67|Q52S67_9HIVl,82320733 |sp|Q52S51 |Q52S51_9HIV1,82320727|sp|Q52S30|Q52S30_9HIVl,82320064|sp|Q9YP36|Q9YP36_9HIVl,82319934|sp|Q9WJW6|Q9WJW6_9HIVl,82319932]sp IQ9WJV8 |Q9WJV8_9HIV1,82319930|sp|Q9WJVl |Q9WJV1_9HIV1,82319928|sp|Q9WJU5|Q9WJU5_9HIVl,82311259|sp|Q77689|Q77689_9HIVl,82308770|sp|Q56CX5|Q56CX5_9HIVl,82308767|sp|Q56CX2|Q56CX2_9HIVl,82308765|sp|Q56CX0|Q56CX0_9HIVl,82308763 |sp|Q56CW8|Q56CW8_9HIVl,82308761 |sp|Q56CW6|Q56CW6_9HIVl,82308759|sp|Q56CW4|Q56CW4_9HIVl,82308757|splQ56CW2|Q56CW2_9HIVl,82308755|sp|Q56CW0|Q56CW0_9HIVl,82308753|sp|Q56CV8|Q56CV8_9HIVl,82308751 |splQ56CV6|Q56CV6_9HIVl582308749|splQ56CV4|Q56CV4_9HIVl,82308747|sp|Q56CV2|Q56CV2_9MVl,82308745|sp|Q56CV0|Q56CV0_9HIVl,82308743|sp|Q56CU8|Q56CU8_9HIVl,82308741 |sp|Q56CU6|Q56CU6_9HIVl,82308739|sp|Q56CU4|Q56CU4_9HIVl,82308737|sp|Q56CU2|Q56CU2_9HIVl,82308735|sp|Q56CU0|Q56CU0_9HIVl,82308733|sp|Q56CT8|Q56CT8_9HIVl,8230873 l|sp|Q56CT6|Q56CT6_9HIVl,82308729|sp|Q56CT4|Q56CT4_9HIVl,82308727|sp|Q56CT2|Q56CT2_9HIVl,

|40021881 |gb|AAR37194.1|40021851 |gb|AAR37173.1 j,|40021821|gb|AAR37152.1|,|40021791|gb|AAR37131.1|,|40021761 |gb|AAR37110.1 j,|40021730|gb|AAR37088.1|,|40021701 |gb|AAR37068.11,|4205053|gb|AAD10926.1|,|4205026|gb|AAD10902.1|,|4204999|gb|AAD10878.1|,|326419|gb|AAB59746.1|,|328442|gb|AAA83396.1|,|329379|gb|AAA45364.1|,|328457|gb|AAA45000.1|,|327825 |gb|AAA44686.1|,

|82312478|sp|Q8AC91|Q8AC91_9HTVl|74273388|gb|ABA01378.1|40021871 jgb | AAR37187.1|40021841|gb|AAR37166.1|40021811 jgb j AAR37145.1|40021781|gb|AAR37124.1|40021751 |gb|AAR37103.1|40021721 |gb |AAR37082.1|4205071|gb|AAD10942.1|4205044|gb|AAD10918.1|4205017|gb|AADl 0894.1|4204990|gb|AAD10870.1|329396|gb|AAB53950.1|329401|gb|AAA45378.1|328636|gb|AAA45061.1|328156|gb|AAA44867.1|327754|gb|AAA44677.1|82320736|sp|Q52S60|Q52S60_9HIVlj8232073ÜispjQ52S4ÍjQ52S4Í_9KTvl|82320166|sp|Q9YTC6|Q9YTC6_9HIVl|82320063|sp|Q9YP32|Q9YP32_9HTVl|82319933|sp|Q9WJW2|Q9WJW2_9HIVl|82319931 |sp|Q9Wm|Q9WJV6_9HIVl|82319929|sp|Q9WJU9|Q9WJU9_9HIVl|82319927|sp|Q9WJU2|Q9WJU2_9HIV 1|82308771|splQ56CX6|Q56CX6_9HTVl|82308769|sp|Q56CX4|Q56CX4_9HIVl|82308766|sp|Q56CXl |Q56CX1_9HIV1|82308764|sp|Q56CW9|Q56CW9_9HIVl|82308762]sp|Q56CW7|Q56CW7_9HIVl|82308760|sp|Q56CW5|Q56CW5_9HIVl|82308758|sp|Q56CW3|Q56CW3_9HrVl|82308756|sp|Q56CWl|Q56CWl_9HIVl|82308754|sp|Q56CV9|Q56CV9_9HIVl|82308752|sp|Q56CV7|Q56CV7_9HIVl|82308750|sp|Q56CV5|Q56CV5_9HIVl|82308748|sp|Q56CV3|Q56CV3_9HIVl|82308746|sp|Q56CVl|Q56CVl_9HIVl|82308744|sp|Q56CU9|Q56CU9_9HIVl|82308742|sp|Q56CU7|Q56CU7_9HIVl|82308740|sp|Q56CU5|Q56CU5_9HrVl|82308738|sp|Q56CU3|Q56CU3_9HIVl|82308736|sp|Q56CUl|Q56CUl_9HIVl|82308734|sp|Q56CT9|Q56CT9_9HTVl|82308732|sp|Q56CT7|Q56CT7_9HIVl|82308730|sp|Q56CT5|Q56CT5_9HIVl|82308728|sp|Q56CT3|Q56CT3_9HIVl|82308726|sp|Q56CTl |Q56CT1_9HIV1|82308725|sp|Q56CT0|Q56CT0_9HIVl,

|82308723|sp|Q56CS8|Q56CS8_9HIVl,

|82308721|sp|Q56CS6|Q56CS6_9BQVl,

|82308719|sp|Q56CS4|Q56CS4_9HIVl,

|82308717|spÍQ56CS2|Q56CS2_9HIVl,

|82308715|sp|Q56CS0|Q56CS0_9fflVl,

|82308713|sp|Q56CR8|Q56CR8_9HIVl,

|82308711 |sp|Q56CR6|Q56CR6_9HIVl,

|82308709|sp|Q56CR4|Q56CR4_9HIVl,

|82308707|sp|Q56CR2|Q56CR2_9HIVl,

|82308705|sp|Q56CR0|Q56CR0_9HIVl,

|82308703|sp|Q56CQ8|Q56CQ8_9HrVl,

|82308701 |sp|Q56CQ6|Q56CQ6_9HIVl,

|82308699|sp|Q56CQ4|Q56CQ4_9HIVl,

|82308697|sp|Q56CQ2|Q56CQ2_9HIVl,

|82308695|sp|Q56CQ0|Q56CQ0_9HIVl,

|82308693|sp|Q56CP8|Q56CP8_9HIVl,

|82308691 |sp|Q56CP6|Q56CP6_9HrVl,

j82308689ispiQ56CF4jQ56CF4_9KIVl,

|82308687|sp|Q56CP2|Q56CP2_9HIVl,

|82308685|sp|Q56CP0|Q56CP0_9HrVl,

|82308683|sp|Q56CN8|Q56CN8_9HIVl,

|82308681 |sp|Q56CN6|Q56CN6_9HIVl,

|82308679|sp|Q56CN4|Q56CN4_9HIVl,

|82308677|sp|Q56CN2|Q56CN2_9fflVl,

|82308675|sp|Q56CN0|Q56CN0_9HIVl,

182308673 |sp|Q56CM8|Q56CM8_9HIVl,

|82308671 |sp|Q56CM6|Q56CM6_9HIVl,

|82308669|sp|Q56CM4|Q56CM4_9HIVl,

|82308667|sp|Q56CM2|Q56CM2_9HIVl,

|82308665|sp|Q56CM0|Q56CM0_9HIVl,

|82308663|sp|Q56CL8|Q56CL8_9HIVl,

|82308661|sp|Q56CL6|Q56CL6_9HIVl,

|82308659|sp|Q56CL4|Q56CL4_9EQVl,

|82308657|sp|Q56CL2|Q56CL2_9HIVl,

|82308655|sp|Q56CL0|Q56CL0_9HIVl,

|82308653|sp|Q56CK8|Q56CK8_9HIVl,

|82308651|sp|Q56CK6|Q56CK6_9HrVl,

|82308649|sp|Q56CK4|Q56CK4_9HrVl,

|82308647|sp|Q56CK2ÍQ56CK2_9HIVl,

|82308645jsp|Q56CK0|Q56CK0_9HIVlJ

|82308643|sp|Q56CJ8|Q56CJ8_9HIVl,

|82308641 |sp|Q56CJ6|Q56CJ6_9HIVl,

|62548193 |gb|AAX86745.11, |62548183|gb|^

|62548163 |gb|AAX86718.11,

|82319606|sp|Q9PXH4|Q9PXH4_9mVl REV-'

|82308724|sp|Q56CS9|Q56CS9_9HIVl|82308722|sp|Q56CS7|Q56CS7_9HTVl|82308720|sp|Q56CS5|Q56CS5_9HIVl|82308718|sp|Q56CS3|Q56CS3_9HIVl|82308716jsp|Q56CS 1 |Q56CS 1_9HIV1|82308714|sp|Q56CR9|Q56CR9_9HIVl|82308712|sp|Q56CR7|Q56CR7_9HTVl|82308710|sp|Q56CR5|Q56CR5_9HIVl|82308708|sp|Q56CR3|Q56CR3_9HIVl|82308706|sp|Q56CRl|Q56CRl_9HIVl|82308704|sp|Q56CQ9|Q56CQ9_9HIVl|82308702|sp|Q56CQ7|Q56CQ7_9HIVl|82308700|sp|Q56CQ5|Q56CQ5_9HIVl|82308698|sp|Q56CQ3|Q56CQ3_9HIVl|82308696|sp|Q56CQl |Q56CQ1_9HIV1|82308694|sp|Q56CP9|Q56CP9_9HTVl|82308692|sp|Q56CP7|Q56CP7_9HIVl|82308690|sp|Q56CP5|Q56CP5_9HIVl]82308688jspjQ56CP3|Q56CP3_9HIVl|82308686|sp|Q56CPl|Q56CPl_9HIVl|82308684|sp|Q56CN9|Q56CN9_9HIVl|82308682|sp|Q56CN7|Q56CN7_9HIVl|82308680|sp|Q56CN5|Q56CN5_9HIVl|82308678|sp|Q56CN3|Q56CN3_9HIVl|82308676|sp|Q56CNl |Q56CN1_9HIV1|82308674|sp|Q56CM9|Q56CM9_9HIVl|82308672|sp|Q56CM7|Q56CM7_9HIVl|82308670|sp|Q56CM5|Q56CM5_9HIVl|82308668|sp|Q56CM3|Q56CM3_9HIVl|82308666|sp|Q56CMl|Q56CMl_9HIVl|82308664|sp|Q56CL9|Q56CL9_9HIVl|82308662|sp|Q56CL7|Q56CL7_9HIVl|82308660Ísp|Q56CL5]Q56CL5_9HIVl|82308658|sp|Q56CL3|Q56CL3_9HIVl|82308656|sp|Q56CLl|Q56CLl_9HIVl|82308654|sp|Q56CK9|Q56CK9_9HIVl|82308652|sp|Q56CK7|Q56CK7_9HIVl|82308650|sp|Q56CK5|Q56CK5_9HIVl|82308648|sp|Q56CK3|Q56CK3_9HIVl|82308646|sp|Q56CKl|Q56CKl_9HIVl|82308644|sp|Q56CJ9|Q56CJ9_9BQVl|82308642|sp|Q56CJ7|Q56CJ7_9HIVl|62548203|gb|AAX86754.1186736.1|62548173|gb|AAX86727.11|132436|sp|P24739|REV_HVlU4Proteínas NEF

{60114(emb |CAA41585.1|,|63S2038|dbj |BAA86701.1{,(6362230jdbj JBAA86714,1j,|6362222Jdbj [Β AA8671 LlJ16362216|dbpÀAS6708.16362203jdbjjB AÁ86705. Ifi|6362111 |dbj]B AA86700,1f>16362058|dbj|B AA86697.1j,[6362029|dbj JB AA86693.1[,|606603|gb|AÀA58320.1f,|ó06597jgbfAAA583l7,l|,|60659l |gbfAAA58 314.1 j >j606S85|gb|AÁÁ583ll.l|,|606579]gbÍAAA58308.1 j,Í606573|gb|AAA58305,l |}]606567jgb|AAA58302.1|,1606561 JgbjAAAS 8299.1 j,(606555lgbiAAA58296.il,l606549fgbiAAA58293.il,[606543jgbiAAA5S290. Ij5|606535|gb[AAA58287.1 j,1606518feblAAA58284.ll,|6065i2|gbiAAA5828ia|>l606506jgbfAAÂ5S278J|606500jgb|AAA58275.1|,l606491fgblAAA58272.il,1606484JgbjAAA58269.il,|60647S|gb|AÁA58266.1|,[606472fgbjAAA58263.1|,|606466fgb[ AAA58260.1|2108041 jgb| AAC57215.1 [,[2108035|gb| AAC57212.11,|2108027|gb|AAC57208J Í(2108021jgb|ÁAC57205.1 j,|2108015jgbj AAC57202.1j,|2108009|gbj AACS 7199.1|2108000igblAAC57195.il,|2107993fgb| AAC57192.1|2107985|gbJÀAC57I88.1|,|2107979jgb(AAC57! 85.1 j»β107973jgbj AAC57 í 82* 1 f,|2107965|gb|ÁAC57I78.1|2107959|gb|AAC57Γ75.1l2107953jgblAAC57172.il,116541334fgb] AAL06127.1

j17352352|gb| AALOl 5 71,1|,|6382036jdbj|BAAS6695.Il,|6362226|dbj|BAA86713.1|,|6362220]dbj |BAA86710,1[,(6362214|dbj |B AA86707.1|6362197|dbj |B AA86704. lj,|6362105|dbjlBAA86699.1},j6362052|dbj fB AAS6696.1|,|6362024|dbjpAA86692J|,Í606Ô01 ]^>|AAA58319.1 f,|6Q6595|gbfAAA583l6.1|,j606589jgb|AAA58313.1|,|606583jgb|AAA58310.113|606577 jgb|AAA58307.1l60657lfgbjAAA58304.il,|606565|^|AAA58301.1|,|606559]gb]AAA5 B298J }-r[606553|gbj AAA58295.1[|606547|gb|AAA58292J |51606541 lgblAAA58289.il,J606533|gbj AAA58286.1[,|6065Í6|gb!AAÁ58283.115í606510|gb|AAA58280.11}j606504jgb|AAA5827?.l1606495jgb|AAA58274.11,|606489|gb| AAÁ58271,1 Ii[606482|gb|AAA58268. Ij5[606476jgbj AAA58265.1 j,{606470jgb | AA A58262.1|,J6Ô6464|gblÂAA58259.11,pi08039|gb IAAC57214.11,|210S031|gb|AA€572l0.1|,|2108025|gb|AAC57207Jjtp1080l9|gb j AAC57204,1 |fl2108013lgblAAC57201.il,P108007|gb| AAC57198.1f,]2107997|gb|AAC57194.1|,|2107989(gb(AAC57190.11,(2107983jgb|AAC57187.1],|2107977|gb| AAC57184,11,12107971,fgb|AÂC57181.1|,pl07963|gb j AAC57177,1j,|2107957|gb | AÀC57174.1j,pi07951lgbjAAC57171.il,116541332jgb | AAL06126. 1(,

|63S2040|dbj (BAA86702.1JsJ6362237|dbj P AA86715.11,[6362224ldbjIBAA86712.il,Í6362218|dbipÁA86709.1I,j6362209jdbj|BAA86706.1|,{6362192]db||B AA86703.1 \>j6362099|dbjjBAA86698. Ifi(6362035|dbj|B AA86694.1J1(6362018jdbj |BAA86691 .lj,[606599|gbjAAA58318.1j,(606593|gb| AAA58315.1],|606587|gb|ÁAÁ58312.1 (,1606581 |gb|ÂAÃ58309.11,|606575|gb|AAA583(M.l|>|606569Ígb|AAA58303. lj,]606563jgb|AAA58300.1 £Í606557ÍeblAAA58297. ILÍ60655ljgbÍÂAA58294.1|í|606545Ígb|AAA58291.1(?j606537jgb|AAÁ58288.11,[606522fgb|AAA58285.11,|6065I4jjgb| AAA58282.1j,|606508|gb|AAA58279.Í|,1606502 gb|AÁA58276.lj,1606493 gb|AAA58273Λ %I6064S7 gbj AA A58270. V|,|606480 gb|AAA58267.1|(606474 gb|AAA58264.1j,(606468 gb|AAA5826l.lf,[606462 gb|AAA58258. Ijt(2108037 gb|AAC572l3 Λ j,(2108029fgbj AAC57209,1J,(2108023 gb|AAC57206.11»P108017 gb|AAC57203.11

pl08011P108005P107995P107987P107981J2107975P107967(2107961P107955P107949

gb|AAC57200. lj,gb|AAC57197.1fígblAAC57193.il,;b|AAC57189.lj,gblAAC57186.il,gblAAC57183.1|5gb[AAC57179.1|,gb|AAC57176.Í|,^|AAC57173.1J}gb|AAC57170.1|,

Jl6541330|gb|AAL06125.1|,16541328|gb|AAL06124.1|,16541322jgblAAL06121.il,16541316|gb|AAL06118.1|,16541310|gb|AAL06115.1|,15430224|gblAAK98513.1 |AF397574_115430220|gb|AAK98511.1 |AF397572_115430216|gb|AAK98509.1|AF397570_l15430212|gb|AAK98507.1|AF397568_l15430208|gb|AAK98505.1 |AF397566_115430204|gb|AAK98503.1|AF397564_l15430200|gb|AAK98501.1 |AF397562_115430196|gb|AAK98499.1|AF397560_l15430192|gb|AAK98497.1 |AF397558_115430188|gb|AAK98495.1|AF397556_l15430184|gb|AAK98493.1 |AF397554_115430180|gb|AAK98491.1 j AF397552_115430176|gb|AAK98489.1|AF397550_l15430172Jgb]AAK98487,ljAF397548_l15430168ÍgbÍAAK98485.1|AF397546_l15430164|gb|AAK98483.1 |AF397544_115430160|gb|AAK98481.1 |AF397542_115430156jgb|AAK98479.1[AF397540_l15430152|gb|AAK98477.1|AF397538_l15430148|gb|AAK98475.1|AF397536_l15430144|gb|AAK98473.1|AF397534_l4324905|gb|AAD17169.1|,4324878|gb|AAD17142.1|,4324853|gb|AAD17117.1|,4324830|gb|AAD17094.11,4324806|gb| AADl 7070.11,4324781 ]gb)AAD17045.11,4324755|gb|AAD17019.1|,8886639|gb|AAF80538.1|AF179368_8,3114561 |gb|AAD03180.11, |3114546|gb|AAD03166.11,2570302|gb|AAC63083.1|, |1537059|gb|AAC55467.1|,2570296|gb| AAC32652.11,6580996|gb|AAF18404.1|AF190128_3,11993206|gb|AAG42638.1|,5733947|gb|AAD49785.1|AF107770_7,3617984|emb|CAA13462.1|, |3617934|emb|CAA13441.1|,

|16541326|gb|AAL06123.1|, |16541324|gb|AAL06122.1|16541320|gb|AAL06120.1|, |16541318|gb|AAL06119.1|16541314|gb|AAL06117.1|, |16541312|gb|AAL06116.1|15430226|gb|AAK98514.1 |AF397575_1|15430222|gb|AAK98512.1|AF397573_l15430218|gb|AAK98510.1 |AF397571_115430214|gb|AAK98508.1|AF397569_l15430210|gb|AAK98506.1|AF397567_l15430206|gb|AAK98504.1|AF397565_l15430202|gb|AAK98502.1|AF397563_l15430198|gb|AAK98500.1|AF397561_l15430194|gb|AAK98498.1|AF397559_l15430190|gb|AAK98496.1 |AF397557_115430186|gb|AAK98494.1|AF397555_l15430182|gb|AAK98492.1 |AF397553_115430178|gb|AAK98490.1|AF397551_l15430174|gb|AAK98488.1|AF397549_l15430170|gb| AAK98486.1 |AF397547_115430166|gb j AAK98484.1 |AF397545_115430162|gb| AAK98482.1 |AF397543_115430158 |gb|AAK98480.1|AF397541_l15430154|gb| AAK98478.1 |AF397539_115430150|gb|AAK98476.1|AF397537_l15430146|gb|AAK98474.1 |AF397535_115430142|gb|AAK98472.1|AF397533_l|4324887|gb|AAD17151.1|4324860|gb|AAD17124.1

|4324896|gb|AAD17160.1|,|4324869|gb|AAD17133.11,|4324845|gb|AAD17109.1|,|4324821|gb|AAD17085.1|,l4324799lgblAAD17063.ll,|4324772|gb )AAD17036.11,

3617964|emb|CAA13455.1|,722230|gb|AAA63881.1|,722224|gb|AAA63878.1|,722218|gb|AAA63875.1|,722212|gb|AAA63872.1|,722205|gb|AAA63 869.1 j,722199|gb|AAA63866.11,722193 |gb|AAA63863.1 j,

|722234|gb|AAA63883.1|,|722228|gb|AAA63880.1|,|722222jgb | AAA63877.1 j,|722216jgb)AAA63874.1|,|722210|gb|AAA63871.1|,|722203 |gb|AAA63868.11,|722197|gb|AAA63865.1|,(722191 jgbj AAA63 862.11,

|4324839|gb|AAD17103.1|4324815 |gb|AAD 17079.1|4324790|gb|AAD17054.1|4324764|gb|AAD17028.r|4324746|gb|AAD17010.1|3114569|gb|AAD03187.11|2570313 |gb|AAC97574.11|25703 33 jgb | AAC32660.11|13560267|dbj|B AB40918.1||6580986|gb|AAF18395.1|AP190127_315733954|gb | AAD49791.11AJF107771_4|3618020|emb|CAA13474.1||3617930|emb|CAA13439.1||722232|gb|AAA63882.1||722226|gb|AAA63879.1 j|722220|gb|AAA63876.1||722214|gb|AAA63 873.1]|722208|gb|AAA63870.1||722201 |gb|AAA63867.11|722195|gb|AAA63864.1||722188|gb|AAA63861.1|,|722186|gb| ΑΑΑ63 860.1 ]|722l 80|gb|AAA63857.1 j|722l 74|gb|AAA63854.1j|722167|gb|AAA63851.1||722161 |gb)AAA63 848.1 ]|722155|gb j AAA63 845.11|722149|gb| AAA63842.11|722142|gb|AAA63839.1||722136|gb|AAA63836.1||722130|gb|AAA63833.1j|722124|gb|AAA63830.1||722117|gb| AAA63 827.11|722111 jgb IAAA63824.1 j|722105|gb IAAA63821.1 j|722099|gb|AAA63818.11|722093jgb j AAA63815.1 j|722086|gb|AAA63812.1 j|722080|gblAAA63809.1||722070|gb|AAA63806.1||349694|gb|AAA02668.1|]306067|gb|AAA02670.1||306054|gb|AAA02663.1 j|306039|gb|AAA02656.11|306026|gb|AAA02650.11|306019|gb|AAA02647.1 j|30601 l|gb|AAA02643.11|306005|gb|AAA02640.1||305999|gb|AAA02637.1||305993 |gb|AAA02633.1 j|6448457|dbj |BAA86905.11,|6448451 jdbj |B AA86902.11,|82307532|sp|Q9WlR4|Q9WIR4|82307530|sp|Q9WIR2|Q9WIR2|82307528|sp|Q9WIR.0|Q9WrR0|82307526|sp|Q9WIQ8jQ9WIQ8|82307524|sp|Q9WIQ6|Q9WIQ6|82307522|sp|Q9WIQ4|Q9WIQ4|82307520|sp|Q9WIQ2|Q9WIQ2182307518|sp|Q9WIQ0|Q9WIQ0|82307516]sp|Q9WIP8|Q9WIP8_|82307514|sp|Q9WIP6|Q9WIP6_|82307512|sp|Q9WIP4|Q9WIP4_|82307510|sp|Q9WIP2|Q9WIP2_|82307508|sp]Q9WIP0]Q9WIP0_!|82307506|sp|Q9WIN8|Q9WIN8|82307504|sp|Q9WIN6|Q9WIN6|82307502|sp|Q9WIN4|Q9WIN4|82307500|sp|Q9WIN2|Q9WIN2

|722184|gb|AAA63859.1|722178|gb|AAA63856.1j|722172|gb|AAA63853.1||722165|gb|AAA63850.1||722159|gblAAA63847.1||722153|gb|AAA63844.11|722147|gb|AAA63841.1||722140|gb IAAA63 838.1 j|722134|gb|AAA63835.lj|722128|gb|AAA63832.1||722122|gb|AAA63829.1J|722115|gb|AAA63826.1||722109jgb IAAA63823.11|722103|gb|AAA63820.1||722097|gbj AAA63817.11|722091 |gb|AAA63814.11|722084|gb|AAA63811.1|Í722077jgbjAAA63808.li|722068jgbjAAÁ63805.ij|306071 |gb|AAA02672.11|30605 8 jgb j AAA02665.1 jÍ306052|gb|AAA02662.1||306037|gb|AAA02655.11|306023 |gbjAAA02649.11|306017|gb|AAA02646.11Í306009|gb|AAA02642.1||306003|gb|AAA02639.1||305997|gb|AAA02636.11|305991 |gb|AAA02634.11,[6448455|dbj|B AA86904.1|,

|722182|gb|AAA63858.1|722176|gb|AAA63855.1|722170|gb|AAA63852.1|722163|gb|AAA63 849.1|722157|gb| AAA63846.1|722151|gb|AAA63843.1|722145jgb | AAA63840.1|722138jgb|AAA63 837.1|722132|gb|AAA63834.1j722126jgb|AAA63831.1|722120|gb j AAA63828.1Í722113|gb|AAA63825.1[722107jgb|AAA63 822.1|72210ljgb|AAA63819.1j722095jgb|AAA63816.1Í722089|gbjAAA63813.1|722082|gb|AAA63810.1|722074|gb|AAA63807.1j7220óóigb|AAA63804.1|306069|gb|AAA02671.1|306056|gb|AAA02664.1|306041|gb|AAA02657.1l|306028|gb|AAA02651.1|306021|gb|AAA02648.1||306013 jgb IAAA02644.1Jj306007jgbjAAA02641.ilj306001 jgb j AAA0263 8.1 j

9HIV1,9HIV1,9HIV1,9HTV1,9HIV1,9HIV1,9HIV1,9HIV1,9HIV1,9HIV1,9HTV1,9HIV1,9HIV1,9HIV1,9HIV1,9HIV1,9HQY1,

|305995|gb|AAA02635.1||6448459|dbj |BAA86906.11Í6448453jdbjÍBAA86903.lj|82307533|sp|Q9WIR5|Q9WIR5_9HIVl|82307531 jspjQ9WIR3ÍQ9W]R3_9HIVl|82307529|sp|Q9WIRl |Q9WIR1_9HIV1|82307527|sp|Q9WIQ9|Q9WIQ9_9HIVl|82307525|sp|Q9WIQ7|Q9WIQ7_9HIVl|82307523|sp|Q9WIQ5|Q9WIQ5_9fflVl182307521 |sp|Q9WIQ3|Q9WIQ3_9HIVl|82307519|sp|Q9 WIQl |Q9WIQ1_9HIV1|82307517|sp|Q9WIP9|Q9WrP9_9HIVl|82307515|sp|Q9WIP7|Q9WIP7_9HIVl|82307513|sp|Q9WIP5|Q9WrP5_9HIVl|82307511 |sp|Q9WIP3|Q9WIP3_9HIVl|82307509|sp|Q9WrPl|Q9WIPl_9HIVl|82307507|sp|Q9WIN9|Q9WlN9_9HIVl|82307505|sp|Q9WIN7|Q9WIN7_9HIVl|82307503|sp|Q9WIN5|Q9WIN5_9fflVl|82307501|sp|Q9WIN3|Q9WIN3_9HIVl|82307499|sp|Q9WINl |Q9WIN1_9HIV182307498|sp|Q9WIN0|Q9WW0_9HIVl,82307496|sp|Q9WIM8 |Q9WIM8_9HIV 1,82307494|sp|Q9WIM6|Q9WIM6_9HIVl,82307492|sp|Q9WIM4|Q9WIM4_9HIVl,82307490|sp|Q9WIM2|Q9WIM2_9HIVl,82307488|sp|Q9WIM0|Q9WIM0_9HIVl,82307486|sp|Q9WIL8 |Q9WIL8_9HIV 1,82307212|sp|Q9W9W3|Q9W9W3_9HIVl,82307197|sp|Q9W9N0|Q9 W9N0_9HIV 1,82307166|sp |Q9 W8U5 j Q9 W8U5_9HIV 1,82306521 |sp|Q9QMF6|Q9QMF6_9HIVl,82306519|sp|Q9QMF4|Q9QMF4_9BQYl,82305554|sp|Q9PWX9|Q9PWX9_9HIVl,82295336|sp|Q89665|Q89665_9HIVl,8228963 l|sp|Q75718|Q75718_9HIVl,3618026|emb|CAA13477.1|, |3618018|emb|CAA13473.1|,3618010jembjcAA13469.lj, |3618008|emb|CAA13468.1|,3618004|embjcAA13466.lj, |3617996|emb|CAA13464.1|,

m~ril---ι_Ι/-< a AlO/icn 11

OUl / J J*tJÍ. JL j,

3617962jembjcAA13454.il,

3617948jembjcAA13448.lj,

3617942|emb|CAA13445.1|,

3617936jembjcAA13442.1|,

475669|gb|AAB04094.1|,

475660jgbjAAB04088.lj,

475651 |gbjAAB04082.lj,

475643jgbjAAB17018.ll,

475635jgbjAAB04074.lj,

475626|gbjAAB04068.lj,

3618024|emb|CAAl 3476.11,

3618012jembjcAA13470.lj,

3617974jemb jcAAl 3460.1 j,

3617952jemb|CAA13450.lj,

1177210jgblAAB38220.il,

1177204|gb|AAB38217.1|,

1177198|gbjAAB38214.lj,

1177192|gb|AAB38211.1|,

1177183 |gbjAAB38207. lj,

1177177jgbjAAB38204.lj,

1177171 |gb|AAB38201.1|,

1177165jgbjAAB38198.lj,

1177159ÍgbjAAB38195.lj,

487255|gb|AAB05026.1|,

1458080|gb|AAB04751.11,

1458074|gbj AAB04748.1 j,

1458068jgbjAAB04745.lj,

1458062jgbjAAB04742.lj,

1458056jgbjAAB04739.lj,

liei '7n'7nu^,Kir· A Λ 1 i/icc 11

[JUl / / W I OlllUjWJ 1 A 1 W . A j,

j3617958jembÍCAA13452.lj,j3617946jembjcAA13447.lj,j3617940jembjcAA13444.il,Í3617928jembjcAA13438.lÍ,|475666|gb|AAB04092.11,|475657jgbÍAAB04086.lj,|475648jgb|AAB04080.lj,|475640jgb|AAB04077.1|,|475632|gb|AAB04072.1|,Í475623jgbjAAB04066.lj,[3618022|emb|C AAl 3475.11,j3618000|embjcAA13465.lj,Í3617968ÍembjcAA13457.1|,|361795ojembjcAA13449.lj,|1177208|gb|AAB38219.1|,|1177202|gb|AAB38216.1|,|1177196|gb|AAB38213.1|,Íll77190jgbÍAAB38210.lj,|1177181|gb|AAB38206.1|,ill77175jgbÍAAB38203.lj,Íll77169jgbÍAAB38200.lj,|1177163jgbjAAB38197.lj,|1353869|gb|AAB36508.1|,|1458084|gb|AAB04753.1|,1145 8078 |gb|AAB04750.11,j 1458072jgbjAAB04747.1 j,Íl458066jgbjAAB04744.lj,jl458060jgb|AAB04741.1|,jl458054jgbÍAAB04738.lj,

|82307497|sp|Q9WIM9|Q9WIM9_9HIVl,|82307495|sp|Q9WIM7|Q9WJM7_9HIVl,|82307493|spjQ9WIM5|Q9WIM5_9HIVl,|82307491 jsp|Q9WIM3 ÍQ9WIM3_9HIV1,j82307489jspÍQ9WIMl ÍQ9WIM1_9HIV1,|82307487|sp|Q9WIL9|Q9WIL9_9HrVl,|82307485|sp|Q9WIL7|Q9WIL7_9HIVl,|82307199|sp|Q9W9N5|Q9W9N5_9HTVl,|82307171|sp|Q9W908|Q9W908_9HIVl,|82307156|sp|Q9W8M8|Q9W8M8_9HIVl,|82306520|sp|Q9QMF5 |Q9QMF5_9HTV 1,|82305566|sp|Q9PX3 7 |Q9PX3 79HIV 1,|82301533|sp|Q97066|Q97066_9HIVl,j82289663|spÍQ75752|Q75752_9HIVl,|82289626jspjQ75713ÍQ75713_9fflVl,|3618014|emb|CAA13471.1|,|3618006|embjcAA13467.1 j,Í3617978ÍembÍCAA13461.lj,

l3617966lemblCAA.l 3456,1 \>Í3617956ÍembjcAAl3451.l[Í3617944ÍembjCAA13446.lj,j3617938|embjcAA13443.lj,Í3617926|embjCAA13437.lj,|475663|gbjAAB04090.lj,Í475654jgbjAAB04084.lj,j475645jgbÍAAB04078.lj,j475638jgbÍAAB04076.lj,Í475629jgbjAAB04070.lÍ,Í475620|gb|AAB04064.lj,|3618016|emb|CAA13472.lj,j3617990|embjcAA13463.lj,|361796ojembjcAA13453.lj,Í3617932jembjcAA13440.lj,|1177206|gb|AAB38218.1|,|1177200|gb|AAB38215.1|,|1177194|gbjAAB38212.lj,|1177188jgbjAAB38209.lj,j1177179jgb jAAB3 8205.1 j,Íll77173ÍgbÍAAB38202.1|,|1177167|gb|AAB38199.1|,|117716ljgb|AAB38196.1|,|487258jgbjAAB05028.lj,11458082jgbjAAB04752.1 j,|1458076jgb|AAB04749.1 j,ll458070jgbjAAB04746.il,jl458064|gbjAAB04743.lj,jl458058jgbjAAB04740.lj,|1458052|gb|AAB04737.1|,|1458050|gb|AAB04736.1|11458044|gb|AAB04733.11jl458038|gb|AAB04730.1||1458032|gb|AAB04727.1|11458026|gb|AAB04724.1 j|1458013|gb|AAB04718.1||1458005|gb|AAB04715.1||1457999|gb|AAB04712.1|11457989|gb| AAB04707.11)1457983|gb|AAB04704.1|11457977|gb|AAB04701.1111457971 |gb|AAB04698.1j|1457965|gb|AAB04695.1||829486|gb|AAA79606.1|,|829480|gb|AAA79603.1|,1829473|gb|AAA79600.1 j,|28872818|ref]NP_057857.2|,

|82311082|sp|Q75000|Q75000_9HIVl,|82308080]sp!Q9YKT6|Q9YKT6_9HI\7l,|82308077|sp|Q9YKS7|Q9YKS7_9HIVl,|82308073|sp|Q9YKR0|Q9YKR0_9HIVl,|82308066|sp|Q9YKN6|Q9YKN6_9HIVl,|82307351|sp|Q9WF95|Q9WF95_9HrVl,|82307347|sp|Q9WF88|Q9WF88_9HIVl,182307341 |sp|Q9WF76|Q9WF76_9HIVls|82307337|sp|Q9WF70|Q9WF70_9HIVl,|82307333|sp|Q9WF64|Q9WF64_9HrVrl,|82307330|sp|Q9WF58|Q9WF58_9HIVl,|82300237|sp|Q90B85|Q90B85_9HIVl,|82300235jsp|Q90B83|Q90B83_9HIVl,|82300233|sp|Q90B81|Q90B81_9HIVl3|82300231|sp|Q90B79|Q90B79_9HrVl,|82300229|sp|Q90B77|Q90B77_9fflVl,|82300227|sp|Q90B75|Q90B75_9HIVl,|82300225|sp|Q90B73|Q90B73_9HIVl,]82300223|sp|Q90B71|Q90B71_9inVl,|82300221|5ρ|ρ90Β69|ρ90Β69_9Ηΐνΐ,|82300219|sp|Q90B67|Q90B67_9HIVl,|82300217|sp|Q90B65|Q90B65_9HlYl,|82300215|sp|Q90B63|Q90B63_9HIVl,|82300213|sp|Q90B61|Q90B61_9HIVls|823002 ll|sp|Q90B59|Q90B59_9HIVl,|82300209|sp|Q90B57|Q90B57_9HIVl,|82300207|sp|Q90B55|Q90B55_9HIVl,|82300205|8ρ|ρ90Β53|ρ90Β53_9Ηΐνΐ,182300203|sp|Q90B51 |Q90B51_9HIV1,|82300201 jsp IQ90B49 |Q90B49_9HTV 1,|82300199|sp|Q90B47|Q90B47_9HIVl,

|1458048|gb|AAB04735.1|1458042|gb|AAB04732.1|1458036|gb|AAB04729.1|1458030|gb|AAB04726.1j1458024|gb | AAB04723.111458009|gb| AAB04717.1|1458003|gb|AAB04714.1|1457997|gb|AAB04711.1|1457987|gb|AAB04706.1|1457981|gb|AAB04703.1|1457975|gb|AAB04700.1|1457969|gb|AAB04697.1|327820|gb|AAB03750.1|829484|gb| AAA79605.11,|829478|gb|AAA79602.1|,1829471 |gb|AAA79599.1|5|14579620|gb|AAK69337.1|,

11458046|gb|AAB04734.1|1458040|gb|AAB04731.1]1458034|gb|AAB04728.1|1458028|gb|AAB04725.1|1458015|gb|AAB04719.1|1458007|gb|AAB04716.1|1458001|gb|AAB04713.111457995 |gb|AAB04710.111457985 |gb|AAB04705.1|1457979|gb|AAB04702.1jl 457973 |gb|AAB04699.1j 1457967|gb|AAB04696.1|829488|gb|AAA79607.1|829482|gb|AAA79604.11829475 |gb|AAA79601.1|328677|gb|AAA45073.1|14579610|gb|AAK69328.1|82308082|sp|Q9YKU0|Q9YKU0_9HTVljB2308078|sp!Q9YKT3!Q9YKT3_9fflVl|82308075 |'sp|Q9YKR6ÍQ9YKR6_9HIVl|82308068|sp|Q9YKP3|Q9YKP3_9HTVl|82308064|sp|Q9YKM9|Q9YKM9_9HTVl|82307349|sp|Q9WF91|Q9WF91_9fflVl|82307344|sp|Q9WF83|Q9WF83_9HrVl|82307339|sp|Q9WF73|Q9WF73_9HIVl|82307335|sp|Q9WF67|Q9WF67_9HIVl182307331 ]sp|Q9WF61 |Q9WF61_9HIV1|82300238|sp|Q90B86|Q90B86_9HTVl|82300236|sp|Q90B84]Q90B84_9HrVl|82300234|sp|Q90B82|Q90B82_9HTVl|82300232|sp|Q90B80|Q90B80_9HIVl|82300230|sp|Q90B78|Q90B78_9HIVl|82300228|sp|Q90B76|Q90B76_9BQYl|82300226|sp|Q90B74|Q90B74_9HIVl|82300224|sp|Q90B72|Q90B72_9HIVl|82300222|sp|Q90B70|Q90B70_9HIVl|82300220| sp |Q90B68 |Q90B68_9HTV 1|82300218|sp|Q90B66|Q90B66_9HIVl|82300216jsp |Q90B64|Q90B64_9HIV1j82300214|spÍQ90B62jQ90B62_9HIVlÍ82300212jspjQ90B60ÍQ90B60_9HIVl|82300210|sp|Q90B58|Q90B58_9HIVl|82300208|sp|Q90B56|Q90B56_9HIVl|82300206|sp|Q90B54|Q90B54_9HrVl|82300204|sp|Q90B52|Q90B52_9HIVl|82300202|sp|Q90B50|Q90B50_9HIVl|82300200|sp|Q90B48|Q90B48_9HrVl|82300198|sp|Q90B46|Q90B46_9HIVl|82300197|sp|Q90B45|Q90B45_9fflVl,|82299526|sp|Q901Vl|Q901Vl_9HIVl,|82299524|sp|Q901U9|Q901U9_9HIVl,|82299522|sp|Q901U7|Q901U7_9HIVl,|82299520|sp|Q901U5|Q901U5_9HrVl,|82299518|sp|Q901U3|Q901U3_9HIVl,|82299516|sp|Q901Ul|Q901Ul_9HTVl,|82299514|sp|Q901T9|Q901T9_9HIVl,|82295323|sp|Q89561|Q89561_9HIVl,|82289530|sp|Q74927|Q74927_9HIVl,|82289528|sp|Q74925|Q74925_9HIVl,|82289526|sp|Q74923|Q74923_9HIVl,|82289524|sp|Q74921|Q74921_9HIVl,|82289522|sp|Q74919|Q74919_9HIV1,|82289520|sp|Q74917|Q74917_9HIVl,|82289518|sp|Q74915|Q74915_9HIVl,182289516|sp|Q74913|Q74913_9HIVl,182289514|sp|Q74911|Q74911_9HIVl,|82289512jsp|Q74909jQ74909_9EIVI,182289510|sp|Q74907|Q74907_9HIVl,|82289508|sp|Q74905|Q74905_9HIVl,|82288074|sp|Q70199|Q70199_9HIVl,|82288045|sp|Q70019|Q70019_9HrVl,|82288043 |sp|Q70015|Q70015_9HIV1,|82288041 |sp|Q70011 |Q70011_9HIV1,|82288039|sp|Q70007|Q70007_9mVl,|82288037|sp|Q70004|Q70004_9HIVl,|82288035|sp|Q70001|Q70001_9fflVl,18228433 l|sp|Q69997|Q69997_9HIVl,|82284329|sp|Q69993|Q69993_9HIVl,|82284327|sp|Q69989|Q69989_9mVl,|82279844|sp|070903|070903_9HIVl,|82279692|sp|041804|041804_9HIVl,|82279687|sp|041781|041781_9HIVl,|2276306|emb|CAB10831.11,|2276300|emb|CAB 10828.11,|2276294|emb|CAB 10825.11,l2276288lemblCAB10822.ll,|2276282|emb|CAB 10819.11,|2276276|emb|CAB 10816.11,16466845|gb|AAFl 3060.1|1123021|gb|AAC54650.1|,|554990|gb|AAB04042.11,|1171196|gb|AAA86259.1|,|1151168|gb|AAA85238.1|,114579600|gb|AAK69319.11,|82306993|sp|Q9QRX0|Q9QRX0_9HIVl,|82306102|sp|Q9QEF2|Q9QEF2_9HIVl,

|2276304|emb|CAB10830.1||2276298|emb|CABl 0827.1 j,|2276292|emb|CAB10824.11,|2276286|emb|CAB 10821.1 j,|2276280|emb|CAB 10818.11,|2276274|emb|CAB10815.1|,|7021462|gb|AAF35361.1|,|1123011 |gb|AAC54641.1|,|60237|emb|CAA44771.1|,|1171194|gb|AAA86258.1|,|665534|gb|AAA76691.1|,

|82300196[sp|Q90B44|Q90B44_9HTVl,|82299525|sp|Q901V0|Q901V0_9HIVl,|82299523|sp|Q901U8|Q901U8_9HIVl,|82299521|sp|Q901U6|Q901U6_9HIVl,|82299519|sp|Q901U4|Q901U4_9HIVl,|82299517|sp|Q901U2jQ901U2_9HIVl,|82299515|sp|Q901UO|Q901UO_9HIVl,|82298954|sp|Q8UMP7|Q8UMP7_9HIVl,|82289533|5ρ|ρ75009|ρ75009_9Ηΐνΐ,|82289529|sp|Q74926|Q74926_9HIVl,|82289527|sp|Q74924|Q74924_9HIVl5|82289525 |sp|Q74922|Q74922_9HIV 1,|82289523 |sp|Q74920|Q74920_9HIVl,|8228952 l|sp|Q74918 |Q74918_9HTV1,|82289519|sp|Q74916|Q74916_9HIVl,|82289517|sp|Q74914|Q74914_9HrVrl,|82289515 |sp|Q74912|Q74912_9HIVl3|82289513|sp|Q74910|Q74910_9HIVl,|S2289511 |sp]Q74908|Q7490S_9HIVl,|82289509|sp|Q74906|Q74906_9HIVl,|82288075|sp|Q70201|Q70201_9HIVl,|82288046|sp|Q70021|Q70021_9HIVl,|82288044|sp|Q70017|Q70017_9HIVl,|82288042|sp|Q70013|Q70013_9HIVl5|82288040|sp|Q70009|Q70009_9HIVl,18228803 8jsp |Q70005 |Q70005_9HIV 1,|82288036|sp|Q70002|Q70002_9HIVlJ|82284332|sp|Q69999|Q69999_9HIVl,|82284330|sp|Q69995|Q69995_9HIVl,|82284328|8ρ|ρ69991|ρ69991_9Ηΐνΐ,|82280443|sp|089293|089293_9HIVl,|82279842|sp|070896|070896_9HIVl,|82279690|sp|041790|041790_9HIVl,|82279685|sp|041773|041773_9HIVl,|2276302|emb|CAB 10829.1],|2276296|emb|CAB 10826.1 j,|2276290|emb|CAB 10823. lj,|2276284|emb|CAB 10820.11,|2276278|emb|CAB10817.1|,|60116|emb|CAA44766.1|,|2801509|gb|AAC82597.11,j 1171192|gb|AAB47920.1 j,|1176382|gb|AAA86737.1|,|1171172|gb|AAA86253.1|,l326372lgbjAAA44192.il,|82318849|sp|Q9DSL7|Q9DSL7_9HIVl,|82306991 |sp|Q9QRWl |Q9QRW1_9HIV1,|82305934|sp|Q9Q713|Q9Q713_9HQYl,|82305932|sp|Q9Q704|Q9Q704_9HIVl,|82304876|sp|Q9IMJl|Q9IMJl_9HIVl,|82300665|sp|Q90iV!M2|Q90MM2_9HIVl,|82300661 |spiQ90MK4|Q90MK4_9HIVl,|82295352|sp|Q89880|Q89880_9HIVl,|82295322|sp|Q89553|Q89553_9HrVl,|82289662|sp|Q75751|Q75751_9HrVl3|82289660|sp|Q75749|Q75749_9HIVl,|82289658|sp|Q75747|Q75747_9HIVl,|82289656|sp|Q75745|Q75745_9HIVl,|82289654|sp|Q75743|Q75743_9HIVl,|82289652|sp|Q75741|Q75741_9HTVl,|82289650|sp|Q75739|Q75739_9HIVl,|82289648|sp|Q75737|Q75737_9HIVl,|82289646|sp|Q75735|Q75735_9HIVl,|82289644|sp|Q75733|Q75733_9HIVl,|82289639|sp|Q75728|Q75728_9HIVl,|82289637|sp|Q75726|Q75726_9HIVl,|82289635|sp|Q75724l,Q75724_9KIVl,|82289633|sp|Q75722|Q75722_9HrVl|82289630|sp|Q75717|Q75717_9HIVl|82289628|sp|Q75715|Q75715_9HIVl|82289497|sp|Q74842|Q74842_9HIVl|82288768|sp|Q72496|Q72496_9HIVl|3618131|emb|CAA13528.1|3618125|emb|CAA13525.1|3618118|emb|CAA13522.1|3618112|emb|CAA13519.1|3618104|emb|CAA13516.1|3618098|emb|CAA13513.1|3618090|embjcAA13509.1|3618084|emb|CAA13506.1|3618078|emb|CAA13503.1|3618072|emb|CAA13500.1|3618066|emb|CAA13497.1|3618060|emb|CAAl 3494.1|3618054|emb|CAA13491.1|3618048|emb|CAA13488.1|3618042|emb|CAA13485.1|3618034|emb|CAA13481.1|3618028|emb|CAAl 3478.1|3850015|emb|CAA76052.1|3618038|emb|CAA13483.1|5070579|gb|AAD39193.1|,l5070576jgbjAAD39190.il,|5070573 jgb |AAD39187.1 j,|5070570jgb |AAD39184.1 j,|5730860|gb|AAD48749.1|AF120922_l,

]3618129|emb|CAA13527.1j3618123|emb|CAA13524.1|3618116|embjcAA13521.1Í3618108ÍembjcAA13518.1j3618102jembjcAA13515.1|3618096|emb|CAA13512.1j3618088jemb|CAA13508.1j3618082jembjcAA13505.1|3618076jemb|CAA13502.1Í3618070|embjcAA13499.1Í3618064jembjcAA13496.1Í3618058jembjcAA13493.1|3618052|emb|CAA13490.1|3618046jemb|CAA13487.1|3618040|embjcAA13484.1|3618032jemb|CAA13480.1Íl568317jembjcAA02191.1|3850013|emb|CAA76051.1|299712|gbjAAB26291.1|5070578|gb|AAD39192.1|,Í5070575jgbjAAD39189.lÍ,Í5070572jgbÍAAD39186.lj,

|82305168|sp|Q9J0G4|Q9J0G4_9HTVl|82302367|sp|Q998E4|Q998E4_9HTVl|82300663|sp|Q90ML3|Q90ML3_9H3Vl|82295355|sp|Q89896|Q89896_9HTVl|82295344|sp|Q89766|Q89766_9HIVl|82289664|sp|Q75753|Q75753_9HIVl|82289661|sp|Q75750|Q75750_9HIVl|82289659|sp|Q75748)Q75748_9HIVl|82289657|sp|Q75746|Q75746_9HrVl|82289655|sp|Q75744|Q75744_9HIVl|82289653|sp|Q75742|Q75742_9HIVl|82289651 |sp|Q75740|Q75740_9HIVl|82289649|sp|Q7573 8 |Q7573 8_9HIV 1|82289647|sp|Q75736|Q75736_9HIVl|82289645|sp|Q75734|Q75734_9HIVl|82289643 |sp|Q75732|Q75732_9HIVl|82289638|sp|Q75727|Q75727_9HIVl|82289636|sp|Q75725|Q75725_9HIVl|82289634isp|Q75723!Q75723_9HIVlÍ82289632ÍspÍQ75719ÍQ75719_9HIVl|82289629|sp|Q75716|Q75716_9HIVl|82289627|sp|Q75714|Q75714_9HIVl|82288908|sp|Q73328|Q73328_9HIVl|385001 l|emb|CAA76050.1|3618127|emb|CAA13526.1|3618121|emb|CAA13523.1|3618114|emb|CAA13520.1|3618106|emb|CAA13517.1|3618100|emb|CAA13514.1|3618094|emb|CAA13511.1|3618086|emb|CAA13507.1|3618080|emb|CAA13504.1|3618074|emb|CAA13501.1|3618068|emb|CAA13498.1|3618062|emb|CAAl 3495.1|3618056|emb|CAA13492.1|3618050|emb|CAAl 3489.1|3618044|emb|CAA13486.1|3618036|emb|CAA13482.1|3618030jemb jc AAl 3479.1|3850017|emb|CAA76053.1|3618092|emb|CAA13510.1|255653|gb|AAB23301.1|5070577|gb|AAD39191.1|5070574|gb|AAD39188.1|5070571|gb|AAD39185.115730861 |gb|AAD48750.1 |AF120923_1|5730859|gb|AAD48748.1 |AF120920_1|5730858|gb|AAD48747.1|AF120919_l|5730856|gb|AAD48745.1|AF120917_l|5730854|gb|AAD48743.1 |AF120915_1|5730852|gb|AAD48741.1 |AF120913_1|5730850|gb|AAD48739.1|AF120911_l|5730848|gb|AAD48737.1|AF120908_l|5730846|gb|AAD48735.1|AF120906_l|5730844|gb|AAD48733.1|AF120904_l|5730842|gb|AAD48731.1 |AF120896_1|5730840|gb|AAD48729.1|AF120894_l|5730838|gb|AAD48727.1|AF120892_l|5730836|gb|AAD48725.1|AF120890_l|5730834|gb|AAD48723.1|AF120888_l|5730832|gb|AAD48721.1|AF120886_l|5730830|gb|AAD48719.1|AF120884_l|5730828|gb|AAD48717.1|AF120882_l|5730826|gb|AAD48715.1|AF120880_l|5730824|gb|AAD48713.1|AF120878_l|5730822|gb|AAD48711.1|AF120876_l|5730820|gb|AAD48709.1|AF120874_l|5730818|gb|AAD48707.1|AF120872_l|5730816|gb|AAD48705.1 |AF120870_1|5730814|gb|AAD48703.1|AF120868_l|5730812|gb|AAD48701.1|AF120865_l|5730810|gb|AAD48699.1|AF120863_l|5730808|gb|AAD48697.1|AF120861_l|5730806|gb|AAD48695.1|AF120859_l|5730804|gb|AAD48693.1 |AF120857_1|5730802|gb|AAD48691.1 |AF120855_1|5730800|gb|AAD48689.1|AF120853_l|5730798|gb|AAD48687.1|AF120851_l|5730796|gb|AAD48685.1 |AF120847_1|5730794|gb|AAD48683.1 |AF120839_1|5730792|gb|AAD48681.1|AF120837_l|5730790|gb|AAD48679.1 |AF120835_1|5730788|gb|AAD48677.1|AF120833_l|5730786|gb|AAD48675.1 |AF120831_1|5730784|gb|AAD48673.1|AP120829_l|573 0782|gb]AAD48671.1 |AF120827_1|5730780|gb|AAD48669.1 |AF120825_1|5730778|gb|AAD48667.1|AF120821_l|5730776|gb|AAD48665.1|AF120817_l|5730774|gb|AAD48663.1|AF120814_l|5730772|gb|AAD48661.1]AP120810_l|5730770|gb|AAD48659.1|AF120808_l|5730768|gb|AAD48657.1|AF120805_l|5730766|gb|AAD48655.1 |AF120803_1|5730764|gb|AAD48653.1|AF120801_l

|5730857|gb|AAD48746.1 |AF120918_1|5730855|gb|AAD48744.1|AF120916_l|5730853|gb|AAD48742.1|AF120914_l|5730851 |gb|AAD48740.1 |AF120912_1|5730849|gb|AAD48738.1|AF120909_l|5730847|gb|AAD48736.1|AF120907_l|5730845|gb|AAD48734.1|AF120905_l|5730843|gb|AAD48732.1|AF120897_l|5730841 |gb|AAD48730.1 |AF120895_1|5730839|gb|AAD48728.1|AF120893_l|5730837|gb|AAD48726.1|AF120891_l|5730835|gb|AAD48724.1|AF120889_l|5730833|gb|AAD48722.1|AF120887_l|5730831|gb|AAD48720.1|AF120885_l|5730829|gb|AAD48718.1 |AF120883_1|5730827|gb|AAD48716.1 |AF120881_1|5730825|gb|AAD48714.1|AF120879_l|5730823|gb|AAD48712.1|AF120877_l|5730821 |gb|AAD48710.1 |AF120875_1|5730819Ígb|AAD48708.1jAFl20873_l|5730817|gb|AAD48706.1|AF120871_l|5730815|gb|AAD48704.1|AF120869_l|5730813|gb|AAD48702.1|AF120867_l|5730811 |gb|AAD48700.1|AF120864_l|5730809|gb|AAD48698.1|AF120862_l|5730807|gb|AAD48696.1|AF120860_l|5730805|gb|AAD48694.1|AF120858_l|5730803|gb|AAD48692.1|AF120856_l|5730801|gb|AAD48690.1|AF120854_l|5730799|gb|AAD48688.1|AF120852_l|5730797|gb|AAD48686.1|AJF120850_l|5730795|gb|AAD48684.1|AF120846_l15730793 |gb|AAD48682.1 |AF120838_1|5730791 |gb|AAD48680.1 |AF120836_1|5730789|gb|AAD48678.1|AF120834_l|5730787|gb|AAD48676.1 |AF120832_1|5730785|gb|AAD48674.1|AF120830_l|5730783|gb|AAD48672.1 |AF120828_1|5730781 |gb|AAD48670.1 |AF120826_1|5730779|gb|AAD48668.1|AF120822_l|5730777|gb|AAD48666.1 |AF120818_1|5730775|gb|AAD48664.1 |AF120815_1|5730773|gb|AAD48662.1 |AF120811_1|5730771 |gb|AAD48660.1 |AF120809_1|5730769|gb|AAD48658.11AF120806_l|5730767|gb|AAD48656.1 |AF120804_1|5730765|gb|AAD48654.1|AF120802_l|5730763|gb|AAD48652.1|AF120800_l|5730762|gb| AAD48651.1 |AF120799_1,

|5730760|gb|AAD48649.1|AF120797_l,

|5730758jgb|AAD48647.1|AF120795_l,

|5730756|gb|AAD48645.1|AF120793_l,

|5730754|gb|AAD48643.1|AF120790_l,

|5730752|gb|AAD48641.1|AF120787_l,

|5730750|gb|AAD48639.1 |AF120785_1,

|5730748|gb|AAD48637.1|AF120777_l,

|5730746|gb|AAD48635.1|AF120774_l,

|5730744|gb|AAD48633.1|AF120772_l,

|5730742|gb|AAD48631.1 |AF120770_1,

|5730740|gb|AAD48629.1|AF120768_l,

|5730738|gb|AAD48627.1|AF120766_l,

|5730736|gb|AAD48625.1|AF120752_l,

|5730734|gb|AAD48623.1|AF120749_l,

|5730732|gb|AAD48621.1|AF120746_l,

|6016896|dbj|B AA85233.1|,

|82307834|sp|Q9WP19|Q9WP19_9fflVl,

|82307832|3p|Q9V,rP17[Q9V,rP17_9KP/l,

|82307830|sp|Q9WP15|Q9WP15_9HIVl5

|82307828|sp|Q9WP13|Q9WP13_9HIVl,

|82307826|sp|Q9WPl 1|Q9WP11_9HIV1,

|82306989|sp|Q9QRL6|Q9QRL6_9HIVl,

|82306987|sp|Q9QRL4|Q9QRL4_9HIVl,

|82306985|sp|Q9QRL2|Q9QRL2_9HIVl,

|82306983 |sp|Q9QRL0|Q9QRL0_9HIVl,

182306981 |sp|Q9QRK8|Q9QRK8_9HIVl,

|82306979|sp|Q9QRK6|Q9QRK6_9HIVl,

|82306977|splQ9QRK4|Q9QRK4_9HIVl,

|82306975|sp|Q9QRK2|Q9QRK2_9HIVl,

|82306973 |sp|Q9QRK0|Q9QRK0_9HIVl,

182306971 |sp|Q9QRJ8|Q9QRJ8_9HIVl,

]82306969|sp|Q9QRJ6|Q9QRJ6_9HIVl,

|82306967|sp|Q9QRJ4|Q9QRJ4_9HIVl,

|82306965|sp|Q9QRJ2|Q9QRJ2_9HrVl,

|82306963 |sp|Q9QRJ0|Q9QRJ0_9HIVl,

|82306961 |sp|Q9QRI8|Q9QRI8_9HIVlJ

|82306959|sp|Q9QRI6|Q9QRI6_9HIVl5

|82306957|sp|Q9QRI4|Q9QRI4_9HIVl,

|82306955|sp|Q9QRI2|Q9QRI2_9HIVls

|82306953|sp|Q9QRI0|Q9QRI0_9HIVl,

|82306951 |sp|Q9QRH8|Q9QRH8_9HIVl,

182306949|sp |Q9QRH6 |Q9QRH6_9HIV 1,

|82306947|8ρ|ρ9(3ΚΗ4|ρ9(2ΚΗ4_9Ηΐνΐ,

|82306945 |sp|Q9QRH2|Q9QRH2_9HIVl,

|82306943|sp|Q9QRH0|Q9QRH0_9HIVl,

|82306941 |sp|Q9QRG8 |Q9QRG8_9HIV1,

|82306939|sp|Q9QRG6|Q9QRG6_9HIVl,

|5730761 |gb|AAD48650.1 |AF120798_1|5730759|gb|AAD48648.1|AF120796_l|5730757|gb|AAD48646.1|AF120794_l|5730755|gb|AAD48644.1|AF120792_l|5730753 |gb|AAD48642.1 |AF120789_1|5730751 |gb|AAD48640.1 |AF120786_1|5730749|gb|AAD48638.1|AF120778_l|5730747|gb|AAD48636.1|AF120776_l|5730745|gb|AAD48634.1 |AF120773_1|5730743 |gb|AAD48632.1|AFl20771_1|5730741|gb|AAD48630.1|AF120769_l|5730739|gb|AAD48628.1|AF120767_l|5730737|gb|AAD48626.1|AF120761_l|5730735|gb|AAD48624.1 |AF120751_1|5730733|gb|AAD48622.1|AF120747_l|5730731 |gb|AAD48620.1 |AF120745_1|82307835|sp|Q9WP20|Q9WP20_9HIVl|82307833 |sp|Q9WP18|Q9WP18_9HIVll82307831lsp!Q9WP16|Q9WP16_9HIVlÍ82307829ÍspÍQ9WP14ÍQ9WP14_9HIVl|82307827|sp]Q9\VP12|Q9WP12_9HIVl|82306990|sp|Q9QRL7|Q9QRL7_9HrVl]82306988|sp|Q9QRL5|Q9QRL5_9HIVl|82306986|sp|Q9QRL3|Q9QRL3_9HIVl|82306984|sp|Q9QRLl |Q9QRL1_9HIV1|82306982|sp|Q9QRK9|Q9QRK9_9fflVl|82306980|sp|Q9QRK7|Q9QRK7_9HIVl|82306978|sp|Q9QRK5|Q9QRK5_9HIVl|82306976|sp|Q9QRK3|Q9QRK3_9HIVl|82306974|sp|Q9QRKl|Q9QRKl_9HIVl|82306972|sp|Q9QRJ9|Q9QRJ9_9HIVl|82306970|sp|Q9QRJ7|Q9QRJ7_9HIVl|82306968|sp|Q9QRJ5|Q9QRJ5_9HIVl|82306966|sp|Q9QRJ3|Q9QRJ3_9HIVl|82306964|sp|Q9QRJl |Q9QRJ1_9HIV1|82306962|sp|Q9QRI9|Q9QRI9_9HIVl|82306960|sp|Q9QRI7|Q9QRI7_9HIVl|82306958|sp|Q9QRI5|Q9QRI5_9HIVl|82306956|sp|Q9QRI3|Q9QRI3_9fflVl|82306954|sp|Q9QRIl |Q9QRI1_9HIV1|82306952|sp|Q9QRH9|Q9QRH9_9HTVl|82306950|sp|Q9QRH7|Q9QRH7_9HIVl182306948jsp IQ9QRH5 |Q9QRH5_9HIV 1Í82306946|sp|Q9QRH3|Q9QRH3_9HrVl|82306944|sp|Q9QRHl|Q9QRHl_9HIVl|82306942|sp|Q9QRG9|Q9QRG9_9HIVl|82306940|sp|Q9QRG7|Q9QRG7_9HIVl|8230693 8 |sp|Q9QRG5 |Q9QRG5_9HIV 1|82306937|sp|Q9QRG4|Q9QRG4 9HIV1,|82306935|sp|Q9QRG2jQ9QRG2~9H3Vl,|82306933jsp [Q9QRG0|Q9QRG0_9HTV1,(82306931 [sp|Q9QRF8|Q9QRF8_9HIVl,|82306929jsp|Q9QRF6|Q9QRF6_9HIVl ,j82306927jsp|Q9QRF4|Q9QRF4_9HlVl,|82306925[sp|Q9QRF2]Q9QRF2_9HIVl,[82306923jsp |Q9QRFO]Q9QRFO_9HIV1,[82306921 |sp|Q9QRE8|Q9QRE8_9fflVl,[82306919[sp |Q9QRB6|Q9QRB6_9HIV1,|82306917|sp|Q9QRE4|Q9QRE4 9HIVI,|82306915|sp|Q9QRE2|Q9QRE2_9HlVls|82306913|splQ9QREO|Q9QREO_9HIVl,18230691 l|sp|Q9QRD8|Q9QRD8_9HIVl,[82306909jsp|Q9QRD6|Q9QRD6_9HIVlJ]82306907|sp|(^QRD4iQ9QRD4_9HIVlJ|82306905|sp|Q9QRD2[Q9QRD2_9HIVls]82306903|sp|Q9QRJDO3Q9QRD0_9fflVl,182306901 [sp|Q9QRC8|Q9QRC8_9HIVl,[82305574jsp jQ9PXA5 |Q9PXA5_9HIV1,j82305572|sp |Q9PX7SJQ9PX78_9HTV1,182305569]splQ9PX55|Q9PX55_9HIVl,[82305562|sp|Q9PX09ÍQ9PX09_9HrVl,182305557jsp |Q9P WZ7 jQ9P WZ79HTV1,|82305552|$p|Q9PWW5|Q9PWW5_9HIVl|82305550ÍspjQ9PWWO[Q9PWWOL9HIVl182305548)sp|Q9P WV2 [Q9P WV2_9HIV1,|823065401sp|Q9QN90|Q9QN90_9fflVl|3252975[gb|AAD12122.1||7416180|dbj [Β AA93741.11,|16S8l84jgb[AAB51054.11,.|74l6240|dbj[BAA93771.1|,[7416234|dbj|B AA93768.1[,|7416228|dbj|BAA93765.1 [,|7416222jdbj |B AA93762. 1 [,|7416216|dbj |B AA93759.1 j,i7416210ldbjlBAA93756.ll,[7416204jdbj [Β AA93753.1j,|7416198 jdbj JBAA93750.1 j517416190|dbj [Β AA93746.1j,[7416184|dbj]BAA93743.1 j,|7416176|dbj|BAA93739. lj,l7416168idbjfBAA93735.il,l74l6162ldbjjBAA93732.il,]7416156j dbj [Β AA93729. 1Ii[74l6148|dbj|B AA93725.1|,|7416142|dbj |B AA93722.1(6382034jdbj |B AA86687.1

alongada,

l7416170fdbjlBAA93736.ll,j1688180|gb j AAB51052.1 [,l7416238ldbjlBAA93770.ll,17416232|dbj lBAA93767.il,|7416226jdbj|BAA93764.lj,l7416220jdbjlBAA93761.il,(7416214 jdbj ]B AA93758,1],[7416208|dbj |B AA93 75 5.11,[7416202|dbjÍBAA93752.1[>j7416194|dbj|BAA9374S.l j,[74161 SSjdbj |B AA93745.1 j,j?416182|dbj [Β AA93742.1[7416174|dbj |B AA93738.1 j,17416166|dbj|BAA93734.11,]7416l60|dbj|BAA93731.1],]7416154[dbj |BAA93728.1 [,l7416146|dbjjBAA93724.1|,|7416140|dbj|BAA93721.11,[6382032[dbjÍB AA86661.lt,

|82306936|spíQ9QRG3jQ9QRG3_9HrVl|82306934|sp|Q9QRGl|Q9QRGl_9fflVl|82306932|sp| Q9QRF9 |Q9QRF9_9HIV 1|82306930jsp|Q9QRF7|Q9QRF7_9HIVÍ[82306928|sp|Q9QRF5 |Q9QRF5_9HIV1|82306926|spjQ9QRF3|Q9QRF3_9HrVl|82306924[sp jQ9QRF 1 |Q9QRF 19HIV1182306922|sp | Q9QRE9 |Q9QRB9_9HIV1|82306920|spÍQ9QRE7 |Q9QRE7_9HIV 1[823069l8]sp[Q9QRE5|Q9QRE5_9HIVlÍ823069l6|sp|Q9QRE3jQ9QRE3_9HIVl182306914jsp jQ9QRE 1 jQ9QREl_9HTV 1182306912jsp|Q9QRD9|Q9QRD9_9HlVl18230691O jsp|Q9QRD7|Q9QRD7_9HIV 1[82306908|sp|Q9QRD5|Q9QRD5 9HIV1|82306906[sp|Q9QRD3jQ9QRJD3_9Hiyij82306904|sp|Q9QRDljQ9QRDl_9HÍYl]82306902]splQ9QRC9[Q9QRC9_9HIV 1|8230690ojspjQ9QRC7ÍQ9QRC7_9HIVl|82305573|sp[Q9PX97[Q9PX97_9HIY 1|82305570|sp[Q9PX56[Q9PX56_9HIV 1[82305568jsp|Q9PX48 [Q9PX48_9HÍV1|82305561jsp|Q9PX04|Q9PX04_9HIVl|82305556]sp[Q9PWZ6|Q9PWZ6_9HrVl[82305551 |sp|Q9PWW2|Q9PWW2_9HIVl[82305549|sp!Q9PWV8 |Q9PWV8_9HIV 1[82305547|sp|Q9PWT7|Q9PWT7_9HrVl]8218034jemb|C AB92794.11l7416l96Jdbj|BAA93749.Í|j7416150|dbj[BAA93726.1||74162421dbj|B AA93772.il|7416236|dbj|BAA93769.1 j[7416230jdbj[BAA93766.1 j[7416224[dbj[BAA93763.11l7416218[dbj[BAA93760.1|[7416212[dbj [BÀA93757.11[7416206|dbj [Β AA93754.1J|7416200|dbj |B AA93751.11[74l6192|dbj |BAA93747, Ij|7416186[dbj |B AA93744.11|74l6178|dbjjBAA93740.1[|7416172|dbj [BAA93737.11[7416164|dbj [Β AA93733.1 j[7416158jdbj |B AA93730.1 j[7416152|dbj [Β AA93 727.1 j[7416144[dbj jB AA93723.1j]1055038|gb|AAA81044.1]|6362012[dbj|BAA86690. lj|6362006|dbj|BAA86689.1|,|6361973|dbj|B AA86685.il,l6361957ldbjlBAA86682.ll,|6361940|dbj|B AA86679.1|,|6361922jdbj JB AA86676.11,|6361904|dbjÍBAA86673.1|,|6361886|dbj|BAA86670.1|,|6361865|dbj|B AA86667.il,|6361848|dbj|BAA86664.1|,|6361801 |dbj |B AA86660.1 j,|4868329|gb|AAD31264.11,|4868323|gb|AAD31261.1 j,|4868317|gb|AAD31258.1|,|4868311|gb|AAD31255.1|,|4868305|gb|AAD31252.1|,|4868299|gb|AAD31249.11,14868293 jgb|AAD31246.1 j,|4868287|gb|AAD31243.1|,I4S6S2S1 |gb|AAD31240.11,|4868275|gb|AAD31237.11,|4868269|gb|AAD31234.1|,14868263 |gb|AAD31231.11,|4868257|gb|AAD31228.11,|4868251 |gb|AAD31225.1|,14868245 |gb|AAD31222.11,|4868239|gb|AAD31219.1|,|4868233|gb|AAD31216.11,|4868227|gb|AAD31213.1|,|4868221|gb|AAD31210.1|,|4868215|gb|AAD31207.1|,|4868209|gb|AAD31204.11,|3193280|gb|AAD03333.1|,|2351785 |gb|AAC59272.11,|23394684|gb|AAN31555.1|23394678|gb|AAN31552.1|23394672|gb|AAN31549.1|23394665|gb|AAN31546.1|23394659|gb|AAN31543.1|23394652|gb|AAN31540.1|23394646|gb|AAN31537.1|23394640|gb|AAN31534.1|23394633|gb|AAN31531.1|23394627|gb|AAN31528.1|17046926|gb|AAL34926.11117046896|gb| AAL34899.11117046866|gb| AAL34872.11|17046836|gb|AAL34845.1||17046810|gb|AAL34822.1|

|6362000|dbj|BAA86688.1|,[6361967|dbj |BAA86684.1 j,|6361951 jdbj |BAA86681.1j6361934|dbj|BAA86678.1|,|6361916|dbj|B AA86675.1|,|6361898|dbj |BAA86672.11,|6361880|dbj |B AA86669.11,|6361859|dbj |BAA86666.11,|6361842|dbj|BAA86663.11,|6361795|dbj|BAA86659.1|,|4868327|gb|AAD31263.11,|4868321 |gb|AAD31260.1 j,|4868315 |gb|AAD31257.1|,|4868309|gb|AAD31254.11,|4868303|gb|AAD31251.1|,|4868297|gb|AAD31248.11,|4868291 |gb| AAD31245.1 j,|4868285|gb|AAD31242.1|,j4868279|gb[AAD31239.11,|4868273|gb|AAD31236.1|,|4868267|gb|AAD31233.1|,|4868261 |gb|AAD31230.1 j,|4868255|gb|AAD31227.1|,|4868249|gb|AAD31224.11,|4868243|gb|AAD31221.1|,|4868237|gb|AAD31218.1|,|486823 l|gb|AAD31215.1|,|4868225|gb|AAD31212.1|,|4868219|gb|AAD31209.1|,|4868213|gb|AAD31206.1|,|4868207|gb|AAD31203.1|,|3193271 |gb|AAD03325:i|,|3378130|gb|AAC28453.1|,|23394682|gb|AAN31554.11,|23394676|gb|AAN31551.11,|23394669|gb|AAN31548.1|,|23394663|gb|AAN31545.lj,|23394657|gb|AAN31542.1 j,|23394650|gb|AAN31539.1|,|23394644|gb|AAN31536.1 j,|23394638|gb|AAN31533.1|,|23394631 |gb|AAN31530.11,|23394625|gb|AAN31527.11,|17046916|gb|AAL34917.1|,117046886|gb|AAL34890.11,117046856|gb|AAL34863.11,117046830|gb| AAL34840.1 j,117046800|gb|AAL34813.1 j,

|6361979|dbj|BAA86686.1|6361962|dbj|BAA86683.1|6361945|dbj|BAA86680.1|6361928|dbj|BAA86677.1|6361910|dbj|BAA86674.1|6361892|dbj|BAA86671.1|6361871|dbj|BAA86668.1|6361853|dbj|BAA86665.1|6361837|dbj|BAA86662.1|4868331 |gb|AAD31265.1|4868325 |gb|AAD31262.1|4868319|gb|AAD31259.1|4868313|gb|AAD31256.1|4868307|gb|AAD31253.1|486830 l|gb|AAD31250.1|4868295|gb|AAD31247.1|4868289|gb|AAD31244.1|4868283 |gb|AAD31241.1|4868277|gb! AAD31238.1Í486827lÍgbÍAAD31235.1|4868265|gb|AAD31232.1|4868259|gb|AAD31229.1|4868253|gb|AAD31226.1|4868247|gb|AAD31223.1|4868241 |gb|AAD31220.1|4868235|gb|AAD31217.1|4868229|gb|AAD31214.1|4868223|gb|AAD31211.1|4868217|gb|AAD31208.1|486821 l|gb|AAD31205.1|2745747|gb|AAC97531.1j 1890692|gb| AAC97549.1|23394686|gb|AAN31556.1|23394680|gb |AAN31553.1|23394674|gb|AAN31550.1|23394667|gb|AAN31547.1|23394661 |gb|AAN31544.1|23394655|gb|AAN31541.1|23394648|gb|AAN31538.1|23394642|gb|AAN31535.1|23394635|gb|AAN31532.1|23394629|gb|AAN31529.1|23394623|gb|AAN31526.1117046906|gb|AAL34908.1|17046876|gb|AAL34881.1117046846jgb|AAL34854.1117046820|gb|AAL34831.1|17046790|gb|AAL34804.1117046780jgb| AAL34795.11>117046750(gb{AAL34768.11,117046720|gb[AAL34741. 1 j,|1704€690|gb|AAL34714. i |f|17046660|gb|AAL34687.1 j,|17046630|gbjAAL34660.1|,ji7046600jgbjAAL34633.ll,j17046570jgbj AAL34606.11,117046540|gb| AAL34579,1 ]»114209306]dbj |B AB55915. Ij5|15788283jgb|AAL07732,l |,|15788253jgblAAL07705.1 j,[18201637[gb|AAL65389.111820163 l]gb]AAL65386.1|,il8201625jgblAAL65383.il,118201619|gb|ÀAL65380.1),jl 8201613lgbtAAL65377.il,jl8201607|gb (A AL65374.1),118201599|gb|AAL65370,1j,

|17046770|gb|AAL34786.1L117046739|gbj AAL34758.1|,|17046710|gb|AAL34732.1|,j l7046680|gb|AAL34705.11,|l7046650|gb|AAL34678.1117046620|gbj AAL34651.11,jl7()46590jgb|AAL34624.1 j,|I7046560|gb|AAL34597.1j,j17046530|gb| AAL34570.1 j,|15788303 |gb|AAL07750.1 |,Il5788273jgb|AAL07723.1|,|15788244|gb|AÁL07697.11,|1820l635|gbfAAL65388.1|,118201629|gb|AAL65385.1|,j18201623jgb|AAL65382.1 j,j18201617|gbjAAL65379.1 j,11820161 lfgblAAL65376.il,jl8201605igb|AAL65373.1118201597|gb|AAL65369.1 f,|18201585|gb|AÀL65363.1i,

jl 8201587|gbfAAL65364,11,jl 8201571 |gb| AAL65356.1 ftruncada,jl 8201567jgb | AAL65354.1 |truiu:ada,jl 8201563jgb j AAL65352.1 j, |18201561 |gb|AAL65351.1|,jl8201545|gb|AAL65343.1[, jl820154ljgblAAL65341.il,jl 8201537jgbjAAL65339.il, jl8201535|gbjAAL65338.lj,jl 8201531jgb)AAL65336.1 j truncada,jl8201527jgb|AAL65334.1|, |1820l525|gb|AAL65333.1],|18201515jgb|AAL65328.1 j,118201509jgbj AAL65325.11 tnmcada,(18201501 |gb|AAL6532Ll], I18201495lgbJAAL65318.il,

)18201491 jgb]AAL65316.1],jl8201485jgblAAL65313jj,[lS2014?9)gb|AAL65310,1 j,ll8201473fgblAAL65307.il,[182014ó7|gb [ AAL65304.11,jl8201461 fgb|AAL6530Ll|,j 18201455JgbfA AL65298< 1 ],118201449|gb|AAL65295.1Í3549113|gb | AAC34564.1 Jjj3549055|gb|AAC34535.lj,|3549037jgbjAAC34526.1 j,3549029jgb j AAC34522.1 j,Í6063086jgbjAAF03126.1Í6063083 |gbjAAF03123.1 j,j6063080jgbj AAF03120.1 j,Í6063077jgbjAAF03117.1 j,J6063074jgbjAAF03114.1 j,Í6063071 (gb[AAF03111.1 j,

j18201489]gb]AAL65315.1],j18201483jgb] AAL65312.1 j,|1820Ι477|§ΗΑΑΧ65309,1|,118201471|gb|AAL65306.1],118201465]gb|ÀAL65303.11,118201459]gb|AAL65300.11,fl8201453|gbÍAAL65297.1|,118201447|gb|AAL65294.11,13549109|gb|AAC34562.1|,(3549049jgb] AAC34532- IJsJ3549033 |gbjAAC34524.1J,[3549027|gb|AAC34521.1|,16063085jgb|AAF03125.11,|6063082jgb|AAF03122.11,|6063079{gb|ÃAF03119.1 j,|6063076jgb| AAF03116.11,|6063073|gb | AAF03113.1],|6063070|gb|AAF03110.1 j,

|17046760|gb|AAL34777,1|17046730|gbjAAL34750.1j17046700jgbjAAL34723,1117046670jgb|AAL34696.1jl7046640jgb]ÀAL34669.1117046610jgb|AAL34642.1jl7046580|gb[AAL34615.1j 17046550jgb|AAL34588.1]17046520|gblAAL34561.1]15788293|gb|AAL0774l.ljl5788263jgb|AAL077l4.1|15787966|gbjAAL07556.1[18201633|gb|AAL65387.lj18201627jgb j AAL65384.1|18201621|gb|AÀL65381.1j 18201615jgb j AAL65378.1j 18201609jgb j AAL65375.1|18201601jgb jAAL65371.1|18201589jgbjAAL65365.1

11 S^U l D / J IgDjAALOIi O D /. i

jl820l569|gb|AAL65355,l]l820l565[gb|AAL65353.ljl 820l547Ígb|AAL65344.ljl820l539|gb|AAL65340.lj18201533jgbjAAL65337.1118201529jgb jAAL65335.1jl820l523 |gbfAAL65332.1I182015H |gbjAAL65326.l118201507jgb j AAL65324.1118201493jgb j AAL65317.1jl8201487ÍgbjAAL65314.1Íl820148ljgbjAAL6531Ll|1820l475ÍgbjAAL65308.1|18201469jgbjAAL65305.1j18201463jgb j AÁL65302.1jl 820l457jgbjAAL65299.1j 1820145 ljgbjAAL65296.1j 18201445|gb}AAL65293.1]3549107|gb|AAC34561.1|3549043|gbjAAC34529.11354903 lfgb|AAC34523,l|6063087|gb|AAF03127.1|6063084|gb|AAF03124.116063081 |gb|AAF03121.1[6063078|gb j AAF03118.1|6063075|g^)|AAF03115.1|6063072|gb]AAF03112.1|6063069!gb|AAF03l09.1|6063068]gb | AAF03108.1 j,|60630d5]gblAAF03105.1|,|6063062|gb]ÀAF03102.11,j3549009(gb|AAC34512.1|,Í3549003tgbjAAC34509.11,j3548988|gb|AAC34502.11,|5805267|gb(AAD51916,1|,j15407116|gb| AAGl5584,1) trancada,|15128l66|gb[AAK84407.1|AF397201_l,

l6063067lgbfAAF03107.il,l6063064lgbtAAF03104.lt,J3549017|gb|AAC34516.1 j,|3549007|gb|AAC34511.1|,Í3548995|gblAAC34505.1|,|3548982|gb| AAC34499.1 j,

l6063066lgblAAF03106.il,|6063063|gb|AAP03103.1|,|3549013|gb[AAC34514,1],Í3549Ô05|gb|AAC345lO. 1|,|3548992|gb | AAC34504.1 j,(3548980jgb IAAC34498.1 j,(15407118|gb[AAGl 5585.11 tamtada,|15407ll4jgb|AAG155S3.1| trancada,l5l28164|gb|AAK84406,l|ÀF397200_l,

jl688178|gb|AAB51051.1||1688 Í72|gb|AAB51048.11,|1688l66|gb[AAB51045.1i,|13172882|gb|AAK14230.1],113540168|gbl AAK29336. Iffj 12004917jgb | AAG44232.1j,(12004913jgb | AAG44230. Ij trancada,112004909]gb | AAG44228,1[ trancada,

11688176jgb| AAB51050.1],ll688l70jgbiAAB51047.il,ll688l64lgblAAB5I044.il,13540188|gb | AAK29354.1 f,12004923|gb|AAG44234.1j,

1688174|gb]AAB51049.11(1688168]gb|AAB51046.lj,(1688 l62|gb]AAB51043.11,113540178]gb| AAK29345.11,I l2004919]gb|AAG44233.1 j,jl2004915|gb(AAG44231.1 j,11200491 ljgblAAG44229.lj,112004907]gbjAAG44227.11 trancada,

I í2004905|gb|AAG44226.1

112ΟΛΛίί0Ο!σ1>Ι Δ A Ο.ΑΑΊ 77. 11

112004893|gb|AAG44220.11,jl2004885lgbiAAG44216.il,112004879fgb(AAG44213,11,112004873jgb] AAG44210,1|,]12004867(gb| AAG44207.1112004855|gb(AAG44204,1j,jl2004851 jgb] AAG44202.1 ] trancada,(12004847|gb|AAG44200.1| trancada,112004841 jgbjAAG44l97.il trancada,

112004903]gb|AAG44225. 1|,112004S97ÍgbiAAG44222.1Lj12004889jgbjAAG44218, I^112004883jgb|AAG44215,1],112004877fgb[AAG44212.1 j,jl2004871jgbfAAG44209. ij,]12004859|gbj AAG44206. lj,

112004825|gb | A AG44189.11.

ll2004829lgblAAG44191.il,j 12004821 |gb(AAG44187.1j,j12004815jgb j AAG44184.1j trancada,jl200481 l|gbjAAG44182.1 f trancada,

]l2004807jgb|AAG44180,1i

112004803jgb1AAG44178.1 j trancada,112004799|gb j AAG44176.11 trancada,] 12004795|gb|AAG44174.1 f, 112004793]gb|AAG44173.1|,

|12004901 |gb(AAG44224.11,112004895lgblAAG44221.ll,j12004887jgb|AAG44217.11,]12004881 |gb|AAG44214,1 j,j12004875jgb jAAG44211.1],jl2004869jgb|AAG44208.1j,|12004857jgbjAAG44205.1],|12004853|gbjAAG44203.1 [,(12004849|gb|ÁAG44201.1| trancada,112004845jgb j AAG44199.1] trancada,jl2004835jgbjAAG44194.lj trancada,

112004789)gb IAAG44171.1],ll2004783lgblAAG44168.il,j12004779jgb|AAG44166,1 j,j12004769jgbj AAG44161,1 j,jl2004762(gbjAAG44158.1|,112004751 |gb|AAG44l55.11,jl2004745jgbjAAG44152.il,|12004739jgb|AAG44149.1],f12004733|gb jAAG44146.11,j 12004726jgb jAAG44143.1 j,j12004720jgb IAAG44140.1 j,112004708|gb | A AG44137.1|,

112004823]gb] AAG44188.1|,112004819]gb| AAG44186.11,112004813|gb IAAG44183.1 ] trancada,|12004809|gb|AAG44181.1|,]12004805|gb|AÀG44179.lj,112004801 |gbjAAG44177.1 |,j12004797|gb jAAG44175.1 j,12004791 jgbjAAG44172.1j,|12004785|gb(AAG44169.1|,

112004787]gb|AAG44170.1|,

(12004781 |gbfAAG44167.11 trancada]12004773jgbfAAG44l63.1 (, (12004771 |gb|AAG44162.1j,

112004767]gb|AAG44160.11,] 12004760|gb|AAG44157.1 (,112004749[gb|AAG44154.11,112004743|gb|AAG44151.11,112004737(gb(AAG44148.11,(12004731 |gb|AAG44145.1|,jl2004724|gb]AAG44142.1],H2004718|gb|AAG44139.1j,111761606|gbjAAG38934. lj>

íl2004765|gb]AAG44159.1j12004758jgb j AAG44156.1],112004747|gb j AAG44153.1 j,112004741Jgbj AAG44150.1 f,112004735|gb j AAG44147.1),|12004729]gb]AAG44144.11,]12004722|gb[AAG44141.1J,j12004716]gb (AAG44138.1],|11761596|gb|AAG38925,l|,11761586|gb|AAG38916.111345187|gb|AAG34634.111345181|gb j AAG34631.111345175|gb|AAG34628.111345169|gb|AAG34625.111345163 |gb| AAG34622.111345157|gb|AAG34619.111345151|gb|AAG34616.111345145|gb|AAG34613.111345139|gb|AAG34610.111345133 |gb|AAG34607.111345127|gb|AAG34604.111345121 |gb|AAG34601.111345115|gb|AAG34598.111345109|gb|AAG34595.111345103|gb|AAG34592.111345097|gb|AAG34589.111345091 |gb|AAG34586.11 i345085jgbjAAG34583.1

11345079|gb|AAG34580.111345070|gb|AAG34577.111345064|gb|AAG34574.111345058|gb|AAG34571.17188381|gb|AAF37747.1|,7188375|gb|AAF37744.1j,7188369|gb|AAF37741.1|,5713170|gb|AAD47831.1|AF166101_l,

|11761576|gb|AAG38907.1|,|11345185|gb|AAG34633.1|,111345179|gb|AAG34630.1 j,111345173 |gb|AAG34627.1 |,jll345167|gb|AAG34624.1|,|11345161|gb|AAG34621.1|,|11345155|gb|AAG34618.1|,lll345149jgblAAG34615.il,|11345143|gb|AAG34612.1|,|11345137|gb|AAG34609.1|,111345131 |gb|AAG34606.11,|11345125|gb|AAG34603.1|,lll345119lgblAAG34600.ll,|11345113|gb|AAG34597.1|,111345107|gb|AAG34594.1 j,|11345101|gb|AAG34591.1|,|11345095|gb|AAG34588.1|,|11345089|gb|AAG34585.1|,

11 11 /Irninui.! A A/TLl/ICOl Il|1

111345077|gb|AAG34579.11,|11345068|gb|AAG34576.1|,|11345062|gb|AAG34573.11,|11345056|gb|AAG34570.1|,|7188379|gb| AAF37746.11,|7188373|gb|AAF37743.1|,

3252955|gb|AAD12104.1|,3252926|gb|AAD12078.1|,4105543 |gb|AAD02459.1|,4105537|gb|AAD02456.1|,4102306|gb|AAD01472.1|,4102300|gb|AAD01469.11,4102294|gb|AAD01466.1|,4102288lgblAAD01463.ll,4102282|gb|AAD01460.11,4102276|gb|AAD01457.1|,4102270|gb|AAD01454.11,4102264|gb| AAD01451.1 j,4102258|gb|AAD01448.1|,3098591 |gb|AAC68858.1|,2290183|gb|AAC58930.1|,2290108|gb|AAC58891.1|,2290089|gb|AAC58880.1|,2290060|gb|AAC58864.1|,2290040|gb|AAC58852.1|,2290021 |gb| AAC5 8841.11,2289994|gb|AAC58826.1|,

|3252945|gb|AAD 12095.11,|4105547|gb|AAD02461.1|,|4105541 |gb|AAD02458.11,|4105535|gb|AAD02455.1|,|4102304|gb|AAD01471.1|,l4102298lgblAAD01468.ll,|4102292|gb|AAD01465.1|,|4102286|gb|AAD01462.1|,|4102280|gb|AAD01459.1|,|4102274|gb|AAD01456.1|,|4102268|gb|AAD01453.1|,|4102262|gb|AAD01450.1|,|4102256|gb|AAD01447.1|,|3098581|gb|AAC68849.1|,|2290122|gb|AAC58899.1|,|2290101|gb|AAC58887.1|,|2290074|gb| AAC5 8872.11,|2290051 |gb|AAC58859.1 j,|2290035|gb|AAC58849.1|,|2290010|gb|AAC5 883 5.11,|2289985|gb|AAC58821.1|,

|11761566|gb|AAG38898.1|,|11345183|gb|AAG34632.1|,111345177|gb|AAG34629.11,jl 1345171 |gb|AAG34626.1|,|11345165|gb|AAG34623.1|,|11345159|gb|AAG34620.11,|11345153|gb|AAG34617.1|,|11345147|gb|AAG34614.1|,|11345141|gb|AAG34611.1|,|11345135|gb|AAG34608.1|,|11345129|gb|AAG34605.1|,111345123 |gb|AAG34602.11,|11345117|gb|AAG34599.1|,jl 1345111 jgb |AAG34596.1 j,|11345105|gb|AAG34593.1|,|11345099|gb|AAG34590.1|,|11345093|gb|AAG34587.1|,111345087|gb|AAG345 84.11,111345081 |gfc|AAG345 81.1 \,|11345072|gb|AAG34578.1|,|11345066|gb|AAG34575.1|,|11345060|gb|AAG34572.1|,|11345054|gb|AAG34569.11,|7188377|gb|AAF37745.1 j,|7188371|gb|AAF37742.1|,|7188367|gb|AAF37740.1|,|3252965|gb|AAD12113.1|,|3252935|gb|AAD12086.1|,|4105545|gb|AAD02460.1|,|4105539|gb|AAD02457.1 j,|4105533|gb|AAD02454.1|,|4102302|gb|AAD01470.1|,|4102296|gb|AAD01467.1|,|4102290|gb|AADO1464.11,|4102284|gb j AADO1461.11,|4102278|gb|AAD01458.1|,|4102272|gb|AAD01455.1|,|4102266]gb|AAD01452.1|,|4102260|gb|AAD01449.1|,|3947934|gb|AAC82624.1|,|2290188|gb|AAC58933.1|,|2290113|gb|AAC58894.1|,|2290092|gb|AAC58882.11,|2290069|gb|AAC5 8869.11,|2290046|gb|AAC58856.1|,|2290028|gb|AAC58845.11,|2289997|gb|AAC58828.1|,|2289982|gb|AAC58819.1|,|1905983|gb|ÀAC57005.1|,jlS99099[gb[AAC56984.1|3025687[gbj AAC40690,1[3025681 [gb|AAC4Q687.11,|2992623|gbJAAC40648.1|,[29926l7|gb|AAC40645.11,|2992611 |gb[AAC40642.1[,|2992604|gb|AAC40639.1 j,|2992598jgb j AAC40636, Iji[2992592jgb j AAC40633.11,11772633jgb| AAC32301. 1[,J3403213jgb IAAC29048. 1 j,|3171209jgb | AAC18382. lj,|3171203|gb|AAC18379.1|,|3171197 jgb | AAC18376.1 j,|3l71l9l|gbJAAC18373,l|,|3171185|gb|AACl 8370.11,[3171179 jgbj AAC18367Jj317U73jgbj;ÁÁCi8364.Íj,l3171167lgblAAC18361.il,l3l69620]gb|AAC17902.1j,|3169614]gb| AAC17899.1 j,|3l69608|gbjÁAC17896. lj,l3169602lgblAAC17893.il,[3169595|gb | AAC17890.1 j,|3169587jgbj AAC17887.1 [,|3169581jgb j AAC17884.1 f,(2351790|gb[ AAB71220.1|,[1899080[gb|AAB68441.11,11749845|gb|AAB42063.1|,|23986229[gb|AAL12190.11,|1469862|gb|AAB05178.1118643018|gb| AAL74053.1 j,|6694604|gbfAAF25319,1[,|6694598|gb[AAF25316.113l6694592lgblAAF25313.il,|6694586|gb[ÂAF25310.1 j,|66945S0jgb|AAF253O7. lj,|6694574]gb j AAF25304.1j,|6694564lgbj AAF25299.1J,]6694556jgb j AAF25295.1|,|6694550jgb]AAP25292.1 j,|6694544Ígb|AAF25289.1[66945381gbj AAF25286. 11,[6694532|gb|AAF25283.1j6694526jgb[AAF25280.1|6694520jgb|AAF25277,1],|6694514|gb|AAF25274,1],

(1899110jgb|AAC56993.1|,[3025691jgb j AAC40692.1j3025685jgb|AAC40689.1 j,|3025679|gb|AAC40686.1|,|2992621|gb|AAC40647. lj,|2992615jgbj AAC40644. lj,|2992609|gbj AAC40641. 1|,|2992602|gb[AAC40638. lj,j2992596[gb[AAC40635.11,J2992590|gb| AAC40632.11,13403231 jgb[AAC29064.1[,|3132819|gb| AAC29085.1|,l3171207lgblAAC18381.il,|3171201 |gb | AAC18378.11,|3171195|gbl AAC18375.1 j,[3Í7llS91gblAAC18372.1|,|317U83|gb|AAC18369fll,|3171177|gb(AACÍ 8366.1],

P l / Jl l / 1 IgOjrtAV-. 1OJOJ. 1|,

|3169624|gb|AÀCl7904.1j,|3l696l8|gb|AAC17901.1[,|3169612|gb|AACl7898.1 |s|3169606IgbjAAC17895.1 j,]3169599[gb|AACl7892.1[,j3169592jgblAAC17889.ll,|3169585[gb | AACl7886,11,[3169579jgb j AACl 7883.11,|2351779jgb|AAB71215.1|,|2194187|gb| AAB61125.1),|23986259[gb| AALl2208.1|23986215|gb[ AALl 2181.1118844745]dbj |B AB85467.11,16694608|gb | AAF25321. lj,[6694602|gb[AAF25318.11,J6694596|gbjAÁF25315.11,j6694590[gb | AAF25312.1 j,|6694584[gb|AAF25309J |,j6694578]gb|AAF25306.11,[6694572jgb | AAF25303.1 j,[669456Ôjgb)AAF25297.1j,|6694554jgb|AAF25294.1 ],|6694548[gb] AAF25291.1j,|6694542[gblAAF25288.1 j,|6694536|gb[AAF25285.1],|6694530|gb[AAF25282.1 j,[6694524|gb|AAF25279.11 trancada,[6694518|gb|AAF25276.11,|6694512|gb|AAF25273.1|,

[1899104jgbfAAC56988.il,|3025689|gb[AAC40691.1|,|3025683jgb[AAC40688.11,|2992625[gb[AAC40649.1|,|2992619|gb|AAC40646.1|,|2992613|gb j AAC40643.1 j,|2992606|gb|AAC40640.1j,|2992600|gb J AAC40637.1[,|2992594|gb|AAC40634,1,jl469161|gb|AAC37975.1j,j3403222[gb!AAC29056.1j3132809jgb|AAC29076.1|3[3171205jgb|AAC18380.1 [,[3171199jgb|AAC18377,l |,|3171193|gb[AAC18374.l|,|317118 7[gb|AAC18371.11,|3171l81[gb|AAC18368.1|,|3171175|gb|AAC18365.1|}|31711v9|gb|AACl8362.1j,j3169622lgblAACl7903.ll,]31696í 6[gb| AACl7900.1],|316961 OlgbJAAC17897.1J,|3169604]gb|AAC17S94.1|,[3 !69597]gb(AÀC17891.11,[3169590|gb jAAC17888.1 [,[3169583|gb[AAC17885.11,[3169577[gb [AAC17882.1 j,l2351236lgblAAB68447.il,|1749847|gb|AAB42064.1|,J23986243|gb | AALL2199.11,|1469864[gb|AAB05189.1|,118844735JdbjjB AB85458.11,|6694606|gbjAAF25320.1|,|6694600[^)| AAF25317.1j,I6694594|gb|AAP25314,1],16694588[gb|AAF25311.1j,|6694582jgb|AAF25308.1j,l6694576igblAAF25305.ll,[6694570|gb|AAF25302, lj,|6694558|gb[AAF25296,l|,|6694552[gb[AAF25293.1 [,[66945461gb| AAF25290.11,J6694540|gb|AAF25287.1j6694534|gb| AAF25284.11,jõ694528|gb] AAF25281.11,|6694522jgb|AAF25278. lj,[6694516|gb|AAF25275.1],|6694510igb|AAF25272.1|,|6694508[gbjAAF25271.1 f, j6694506[gb[AAF25270.11, ]6694504|gb|AAF25269.1|,]6694502|gbj AAF25268.1|6694500[gb|AAF25267.1J, |6694498|gb|AAF25266.lj,|6694496|gb[AAF25265.1 j, [6694494jgbjAAF25264.il, j6694492|gb|AÁF25263.1|,J6694490jgbj AAF25262.11, |6694488|gb[AAF25261.11, |6694486|gb|AAF25260.1j,(6694484 IgbjA AF25259.1]6694482[gb|AAF25258.1 j truncada,|6694480|gb|AAJF25257.1| tnmeada, |6694478tgb|AAF25256.1| trancada,

[6694476|gb|AAF25255.1 j truncada, |6694474|gb|AAF25254.1| trancada,

[6694472|gbfAAF25253.1) trancada, |6694470|gb|AAF25252.1| tramada,

|6694468|gb[AAJF2525U] trancada, j6694466|gb[AAF25250,11 trancada,

[6694464|gb| AAF25249.1|6694462|gb[AAF25248.1|, . l6694460lgblAAF25247.ll,[6694458|gb|AAF25246.1), |6694456]gb|AAF25245.1|, |6694454|gb|AAF25244.1 j,|6694452|gb[AAF25243, lj, |6694450|gb|AAF25242J j, |6694448[gb|AAF2524Ll|,|6694446|gb[AAF25240.1 i, |6694444|gb|AAJF25239.1|, [6694442[gb(AAF25238.1|,|6694440jgb[AAF25237. If trancada, I6694438|gb|AAF25236. Ij trancada,

|6694436|gb[AAF25235.1[6694434|gb|AAF25234.1|, |6694432|gb|AAF25233.1j,j6694430lgb | AAF25232.11, |6694428|gb|AAF25231.1|6694426|gb|AAF25230.11,110880736|gb | AAG24369.11, |16751265|gb|AAL05340.1|1675l255[gb|AAL0533Ul,]16751247jgb | AAL05324.1[, [16751236|gbjAAL05314.1 J,

[15231507igb[ AAK94289.1 [ AF3 61 °79_9, |15281497^[ΑΑΚ94280.1|ΑΡ361878_9,

j15281487|gbjAAK94271.1 [ÁF361877 9, |l5281478jgb[AAK94263.1 |AF36lS76_9,

115281468[gb IAAK94254.1(AF361875^9, |15281458|gjb|AAK94245.1|AF361874_9,

jl5281448|gb| AAK94236.11AF361873_9„ [15281438|gb[AAK94227.1 |AF361872_9,

115281428fgbjAAK94218.1j AF36I871__9, |14530235jgb|AAEC65969.1 |AF286236 9,

|3002848|gblAAD03207.11, |3002838|gb|AAD03198.1|, [5931499|dbjIBAA84676.11,|5931490|dbj |BAA84668.1|, [13517091 [dbj|BAB40429. lj, ]3779267|gb[AAD03315.1 j,|14530270]gb[ÂAK66000.1 [AF316544_9, [14530261 |gbjAAK65992.1 ]AP2S6239_9,

jl4530253|gb|AAK65985.1JAF2S6238_9, |14530244[gb|AAK65977.1]AF286237_10,

Il 3569336|gb[AAK31070.1 |AF286235_9, |13569326|gb]AAK31061.1|AF2S6234_9)

[13569316|gb[AAK31052.1 [AF286233_9, |13569306|gb?AAK31043.1|AF2S6232_9,

j 13569296]gb j AAK31034.1 [AJF286231_9, |13569286|gb|AAK31025.1[AF286230_9,

|13569276]gbtAAK310l6.1|AF286229_9, jl3569256|gbjAAK30998.1 jAF286227_9,

113569246]gb[AAK30989.1 [AF286226 9, |13569236|gb|AAK30980.1 |AF286225_9S

113569226jgb[AAK30971.1 |AF286224l9, |135692l6|gb|AAK30962.1|AF286223_9,

|11321029jgb|AAG34020>l|, [1132lOl9|gb|AAG34011.1 [, |11321009|gb]AAG34002.1|,|11320999lgblAAG33993.lt (11095919|gb[AAG30123.1(AF286365_9,

|11066506|gb|AAG28621.1 [AF259955_9, |11066496|gb[AAG28612.1|AF259954_9,

[3808286|gb | AAC69312.11, [5305362jgb|AAD41614.1[AF071474_9s

|5305350[gb|AAD41604.1 |AF071473_9, |3808278|gb|AAD13365.1|,

J3808269|gb] AAC69305.1[, l3808259[gb|AAC69296.1|, [3808249|gb|AAC69287.1|,[6651483|gb | AAF22331.11AFl93277_4, |6651474(gb|AAF22322.1|AFl93276_4,

|6643032[gb|AAF20393.1|, |6651460ÍgbjAAF22312J|AF193253_6,

[6090973[gb|AAF03420.11AF075703 8, |5668962[gb[ AAD46106.1 |AF076998_8,

j5668947|gb|AAD46095.1|AF077336_9, |6910976|gb|AAF31327.1|AF146728Jl,

]2944131 |gbj AAC05238.1j, |5668931 |gb]AAD46083,1 |AF076475„9,

(5668918|gb|AAD46072.1}AF076474_8, |566S888[gb|AAD46050.1|AF075701_8,

|5305485|gb|AAD41673.1 [AF075702 8, |5059058|gb[AAD38897. IjAFl 19820_9,

|5059Ó49jgb|AAD38889.1 [AFl 19819β, (4097723[gb| AAD00166.1|,

[4097720jgb [AAD00165.1 [, |2231611 lgbjAAC59358.il, [2231607[gb!AAC59356.1 j,|2231604|gb| AAC59354.1|,|2231597|gb|AAC59350.1 |,|2281661|gb|AAB64171.1|,|21633164|gb|AAL65475.11,|21633158|gb|AAL65472.1|,|21633152|gb|AAL65469.1j,|21633146|gb|AAL65466.11,|21633140|gb| AAL65463.11,l21633134lgblAAL65460.ll,|21633128|gb|AAL65457.1|,|21633122|gb|AAL65454.1j,|21633116|gb|AAL65451.1|21633108|gb|AAL65579.1|,|21633102|gb|AAL65576.1|,|21633095|gb|AAL65573.1|,|21633089|gb|AAL65570.1|,|21633083|gb|AAL65567.1|,|21633077|gb| AAL65564.11,

!'"ϊ Λ ÍZ**λτ/μ ι a at /τγ^ι ι 1

jZ 10 J^U / 1.1 j,

|21633060|gb|AAL65558.1|,|21633054|gb|AAL65555.1|,|21633048|gb|AAL65552.1|,|21633042|gb|AAL65549.1|,|21633036|gb|AAL65546.1j,|21633029|gb|AAL65543.1|,|21633023|gb|AAL65540.1|,|21633017|gb|AAL65537.1|,|21633011|gb|AAL65534.lj,|21633005|gb|AAL65531.1|,|21632998|gb|AAL65528.1|,|21632992|gb|AAL65525.lj,|21632986|gb|AAL65522.1|,l21632980lgblAAL65519.ll,|21632973|gb|AAL65516.11,|21632966|gb|AAL65513.1|,|21632959|gb|AAL65510.1|,|21632953|gb|AAL65507.1|,|21632947jgb j AAL65504.1 j,|21632941 |gb|AAL65501.11,|21632935|gb|AAL65498.1|,|21632929|gb|AAL65495.1|,|21632922|gb|AAL65492.1|,|21632916|gb|AAL65489.1|,|21632910|gb|AAL65486.1|,|21632904|gb|AAL65483.11,|21632898|gb|AAL65480.1|,|21632892|gb|AAL65477.1|,|21632886|gb|AAL65447.1|,

|2231602|gb|AAC59353.1|,|2231595|gb|AAC59349.11,|14289991 |gb|AAK59179.1|,|21633162|gblAAL65474.1|,|21633156|gb IAAL65471.11,|21633150|gb| AAL65468.11,|21633144|gb|AAL65465.1|,|21633138|gb|AAL65462.11,|21633132|gb|AAL65459.1|,|21633126|gb|AAL65456.11,|21633120|gb|AAL65453.1j,121633112|gb|AAL65450.1|,|21633106|gb|AAL65578.1|,|21633100|gb|AAL65575.1|,|21633093 |gb|AAL65572.11,|21633087|gb|AAL65569.11,121633081 jgbj AAL65566.11,|21633074|gb|AAL65563.1|,

mi OOA^OLUI AAT /ccc/cn 11

|21633058|gb|AAL65557.1|,|21633052|gb| AAL65554.11,|21633046|gb|AAL65551.1|,|21633040|gb|AAL65548.1|,|21633033|gb|AAL65545.1|,|21633027|gb|AAL65542.1|,121633021 |gb|AAL65539.11,|21633015|gb|AAL65536.1|,|21633009|gb| AAL65533.1 \,|21633002|gb]AAL65530.1|,|21632996|gb|AAL65527.1 j,|21632990|gb|AAL65524.11,|21632984|gb| AAL65521.11,|21632978|gb|AAL65518.1|,|21632971|gb|AAL65515.1|,|21632964|gb|AAL65512.1|,|21632957|gb|AAL65509.1|,|21632951 jgbj AAL65506.1 j,|21632945|gb|AAL65503.11,|21632939|gb|AAL65500.1|,|21632933|gb|AAL65497.1|,\21632926|gb|AAL65494.11,|21632920|gb)AAL65491.1],|21632914|gb|AAL65488.1|,|21632908|gb|AAL65485.1|,|21632902|gb|AAL65482.1|,|21632896|gb|AAL65479.1|,|21632890|gb|AAL65449.1|,|21632882|gb|AAL65446.1|,

|2231600|gb|AAC59352.11,|32865 l|gb|AAC32231.1|,21633166|gb|AAL65476.1|,21633160jgblAAL65473.il,21633154|gb|AAL65470.1|,21633148|gb|AAL65467.11,21633142|gb|AAL65464.1|,21633136|gb|AAL65461.1|,21633130|gb|AAL65458.1|,21633124|gb|AAL65455.11,21633118lgblAAL65452.il,21633110|gb|AAL65580.1|,21633104|gb|AAL65577.1|,21633097|gb|AAL65574.1|,21633091|gb|AAL65571.1|,21633085|gb|AAL65568.1|,21633079|gb|AAL65565.1|,21633072|gb|AAL65562.1|,

ll«ín«UlA ΔT Λ^ς^Ο 11

^ X UJ ^ \S\S«S j ^Wj-L kl U^V·/ · Aj^

21633056|gb|AAL65556.1|,21633050|gb|AAL65553.1|,21633044|gb|AAL65550.1|,21633038|gb|AAL65547.1|,21633031|gb|AAL65544.1|,21633025jgbj AAL65541.1 j,21633019|gb|AAL65538.1|,21633013|gb|AAL65535.1|,2'1633007|gb|AAL65532.1j,21633000|gb|AAL65529.1|,21632994|gb| AAL65526.1j,21632988|gb|AAL65523.1|,21632982|gb|AAL65520.1|,21632976|gb|AAL65517.1j,21632968 |gb| AAL65514.1 j,21632961 jgbj AAL65 5 ll.lj,21632955jgbjAAL65508.lj,21632949jgbjAAL65505.lj,21632943 |gb|AAL65502.lj,21632937jgbjAAL65499.11,21632931 jgbjAAL65496.1 j,21632924jgbjAAL65493.lj,21632918jgbjAAL65490.lj,21632912jgbjAAL65487.lj,21632906ÍgbjAAL65484.1|,21632900jgbjAAL65481.1 j,21632894jgb|AAL65478.lj,21632888jgb|AAL65448.lj,21632879jgbjAAL65445.1 j,21632877|gb|AAL65444.121632871 jgbj AAL65441.121632858|gb|AAL65438.1|21632852|gb|AAL65435.1121632846|gb|AAL65432.1 j21632840|gb|AAL65429.121632834|gb|AAL65426.1]21632827|gb |AAL65423. lj21632821 |gb| AAL65420.1 j21632815|gb|AAL65417.1|21632809|gb|AAL65414.1|21632803|gb|AAL65411.1|59805181 jgb|AAX08136.159805175|gb|AAX08133.159805169|gb|AAX08130.159805163 |gb|AAX08127.159805157|gb|AAX08124.111401120]gb|AAC54988.1|,1401114jgbjAAC54985.lL1401108jgb|AAC54982.l[1401102|gb|AAC54979.11,1401096|gb|AAC54976.1|51401090|gb|AAC54973.1],53690223|gb|AAU90015.11,53690217|gb|AAU90012.1|,53690211 |gb|AAU90009.1|,53690205|gb|AAU90006.11,53690199|gb|AAU90003.1 j,53690193 |gb|AAU90000.11,53690187|gb|AAU89997.1j,53690180|gb|AAU89994.11,53690174|gb|AAU89991.1|,53690168|gb|AAU89988.1|,53690162|gb|AAU89985.1|,

|21632875|gb|AAL65443.1|,|21632869|gb|AAL65440.1|,\21632856|gb| AAL65437.1 j,|21632850|gb|AAL65434.1|,l21632844jgblAAL65431.il,l21632838jgbjAAL65428.il,|21632832|gb|AAL65425.1|,j21632825 |gb|AAL65422.11,121632819|gb|AAL65419.11,|21632813 |gb|AAL65416.1 j,|21632807|gb|AAL65413.lj,|21632801|gb|AAL65410.1|,|59805179|gb|AAX08135.11,|59805173|gb|AAX08132.1 j,|59805167|gbj AAX08129.1 j,Í59805161 |gbjAAX08126.11,1140112,4|gb|AAC54990.1 j,|1401118|gb|AAC54987.1|,ll401112lgblAAC54984.il,jl401106|gbjAAC54981.1|,11401100|gb|AAC54978.1 j,|1401094|gb j AAC54975.1 j,|1401088lgb|AAC54972.1|,|53690221|gb|AAU90014.1|,|53690215|gb|AAU90011.1|,|53690209|gb|AAU90008.1|,Í53690203 jgb jAAU90005.11,|53690197|gb|AAU90002.1|,|53690191 |gb|AAU89999.1|,Í53690185|gbÍAAU89996.1|,|53690178|gb|AAU89993.1|,|53690172|gb|AAU89990.1|,|53690166|gb|AAU89987.1|,|53690160|gb|AAU89984.1|5

78714208|gb|ABB51086.1|,

18699182|gbjAAL78444.1|AF413985_l,18699178jgb|AAL78442.1|AF413983_ls56783227|gb|AAW28926.1|, |56783225|gb)AAW28925.1j,

56783221 |gb|AAW28923.11,56783215|gb|AAW28920.lj,56783209|gb|AAW28917.1|,56783203|gb|AAW28914.lj,56783197|gb|AAW28911.1 j,5678319 ljgbjAAW28908.ll,56783185|gb|AAW28905.1|,47779136|gb|AAT38452.1|,47779130jgbjAAT38449.1 j,47779124jgb |AAT38446.1 j,

|56783219|gb|AAW28922.1|,

j56783213Ígb|AAW28919.lj,

|56783207jgbjAAW28916.lj,

|5678320ljgbjAAW28913.lj,

j56783195ÍgbjAAW28910.lj,

Í56783189ÍgbÍAAW28907.lj,

|56783183 |gb|AAW28904.11,

|47779134|gb|AAT38451.1|,

|47779128|gb|AAT3 8448.1 j,

|47779122|gb jAAT3 8445.1 j,

|21632873|gb|AAL65442.1j2163286ljgbjAAL65439.1||21632854jgb|AAL65436.l!j21632848ÍgbjAAL65433.1Í21632842jgbÍAAL65430.1|Í21632836|gb|AAL65427.1|2163283 0|gb|AAL65424.1 j121632823 jgb j AAL65421.11|21632817jgbjAAL65418.1j2163281ljgbÍAAL65415.1||21632805jgbjAAL65412.1|59805183|gb|AAX08137.ljÍ59805177jgbjAAX08134.11j5980517ljgbjAAX08131.ilÍ59805165jgbjAAX08128.1||59805159|gb|AAX08125.lj11401122|gb|AAC54989.1 j|1401116jgbjAAC54986.1|11401110|gbjAAC54983.ljjl401104jgbjAAC54980.lj|1401098jgbjAAC54977.1 jjl401092Ígb|AAC54974.1|jl401086Ígb|AAC54971.lj|53690219|gb|AAU90013.1|Í53690213ÍgbjAAU90010.1|j53690207|gbÍAAU90007.1||53690201 jgb| AAU90004.11Í53690195jgb|AAU90001.1|[53690189jgb|AAU89998.1 jÍ53690183ÍgbjAAU89995.1||53690176|gb|AAU89992.1|Í53690170jgbjAAU89989.ljÍ53690164|gbjAAU89986.ljj53690158jgbÍAAU89983.lj|18699184|gb|AAL78445.1|AF413986_ljl8699180jgbjAAL78443.ljAF413984_l|56783229|gb|AAW28927.1||56783223 jgb jAAW28924.lj|56783217|gb|AAW28921.1||5678321 ljgb|AAW28918.1 j|56783205|gb|AAW28915.11|56783199|gb|AAW28912.1||56783193|gbÍAAW28909.1||56783187|gb|AAW28906.11|47779138|gb|AAT38453.1||47779132|gb|AAT38450.11|47779126|gb|AAT38447.11|47779120jgbjAAT38444.1 j|47779118|gb|AAT38443.1|47779112|gb|AAT38440.1|47779106|gb|AAT38437.1|477791 OOjgbj AAT38434.1|47779094|gb|AAT38431.1|47779088|gb|AAT38428.1|47779082|gb|AAT38425.1|47779076|gb|AAT38422.1|47779070|gb|AAT38419.1|47779064|gb | AAT3 8416.1|47779058|gb|AAT3 8413.1|22759338|gb|AAN05793.1||1277017|gb|AAC55006.1j 1277011 jgb IAAC55003.1|1277005|gb|AAC55000.1|1276999|gb|AAC54997.111276993|gb| AAC54994.1j 1276987|gb|AAC54991.1|862875 jgb|AAA87548. Ij|862869|gb|AAA87545.11862863 |gb|AAA87542.1|862857|gb|AAA87539.1|86285 l|gb|AAA87536.1|862845|gb|AAA87533.1|862839|gb| AAA87530.1|862833|gb|AAA87527.1|862827|gb|AAA87524.1|862821|gb|AAA87521.1|862815|gb|AAA87518.1|862809|gb|AAA87515.1||862803 |gb|AAA87512.11|862797|gb|AAA87509.1 j|86279 l|gb|AAA87506.11|862785|gb|AAA87503.1||862779|gb|AAA87500.1 ]1862773|gb|AAA87497.11|862767|gb|AAA87494.1|1862761 |gb|AAA87491.111862755 |gb|AAA87488.11|862749|gb|AAA87485.1|1862743 |gb|AAA87482.11|862737|gb|AAA87479.1 j|86273 l|gb|AAA87476.11|862725|gb|AAA87473.1||862719|gb|AAA87470.1|j 862713 jgbj AAA87467.1 j|862707|gb|AAA87464.1 j|328380|gb|AAA44981.1|

|47779116|gb|AAT38442.1147779110lgbjAAT38439.ll,|47779104|gb|AAT38436.1|,|47779098|gb|AAT38433.1|,|47779092|gb|AAT38430.1|,|47779086|gb|AAT38427.1|,l47779080lgbjAAT38424.il,|47779074|gbj AAT3 8421.1 j,Í47779068jgbj AAT3 8418.1 j,Í47779062jgbjAAT38415.lj,|47779056|gb|AAT38412.1|,tnmcada, |1277021|gbjAAC55008.|1277015|gb|AAC55005.1|,|1277009|gb|AAC55002.1|,|1277003|gb|AAC54999.1|,j 1276997|gb|AAC54996.11,j 1276991 jgb j AAC54993.1 j,|862879|gb|AAA87550.lj,jS62873 jgbjAAA87547.1 Ji|862867|gbj AAA87544.1 \,j862861 jgbj AAA87541.1 j,|862855ÍgbÍAAA87538.lj,|862849ÍgbjAAA87535.lj3j862843 jgbj AAA87532.1 j,Í862837ÍgbÍAAA87529.1|,j86283ljgbÍAAA87526.lj,1862825 jgb jAAA87523.1 j,(862819jgbj AAA87520.1 j,Í862813ÍgbjAAA87517.1|,Í862807jgbjAAA87514.lj,Í86280ljgbÍAAA87511.lÍ,|862795|gb|AAA87508.11,|862789|gb|AAA87505.1|,|862783|gb|AAA87502.1|,|862777|gb|AAA87499.1|,1862771 |gb|AAA87496.1|,|862765|gb|AAA87493.1|,|862759|gb|AAA87490.1 j,|862753 |gb|AAA87487.1|,|862747|gb|AAA87484.1|,|862741 |gb|AAA87481.1|,|862735|gb|AAA87478.1|,|862729|gb|AAA87475.1|,|862723 |gb|AAA87472.1|,|862717|gb|AAA87469.1 j,|86271 l|gb|AAA87466.1|,l862705lgblAAA87463.ll,|328378|gb|AAA44980.1|,

|47779114|gb|AAT38441.1|,|47779108|gb|AAT3 8438.1|47779102|gb|AAT3 8435.1|47779096|gb|AAT38432.1|47779090|gb|AAT38429.1|47779084|gb|AAT38426.1|47779078|gb|AAT3 8423.1|47779072|gb|AAT38420.1|47779066|gb|AAT38417.1|47779060|gb|AAT38414.1|47779054|gb|AAT38411.11|, |1277019|gb|AAC55007.111277013 |gb| AAC55004.1|1277007|gb|AAC55001.1|1277001|gb|AAC54998.1|1276995|gb|AAC54995.1|1276989|gb|AAC54992.1|862877|gb|AAA87549.1j862871jgbjAAA87546.ilÍ862865ÍgbjAAA87543.l'|862859|gb|AAA87540.1|862853|gb|AAA87537.1|862847|gb|AAA87534.1|862841 jgbj AAA87531.1|862835|gb|AAA87528.1|862829|gb|AAA87525.1|862823|gb|AAA87522.1|862817|gb|AAA87519.1|8628 ll|gb|AAA87516.1|862805|gb|AAA87513.1|862799]gb|AAA87510.1|862793 |gb|AAA87507.1|862787|gb|AAA87504.11862781 |gb|AAA87501.1|862775|gb|AAA87498.1|862769|gb|AAA87495.1|862763 |gb|AAA87492.1|862757|gb|AAA87489.1|86275 l|gb|AAA87486.1|862745|gb|AAA87483.1|862739|gb|AAA87480.1|862733|gb|AAA87477.1j862727|gb|AAA87474.118627211gb | AAA87471.1|862715|gb|AAA87468.1|862709|gb|AAA87465.1|474897|gb|AAA44918.1|328376|gb|AAA44979.1328374|gb|AAA44978.1328368|gb|AAA44975.1328362|gb|AAA44972.1328356|gb|AAA44969.1328350|gb|AAA44966.1328344|gb|AAA44963.1328338|gb|AAA44960.1328332|gb|AAA44957.1328326|gb|AAA44954.1328320|gb|AAA44951.1328314|gb|AAA44948.1328308|gb|AAA44945.1328302|gb|AAA44942.1328296|gb|AAA44939.1328290|gb|AAA44936.1328284|gb|AAA44933.1328278|gb|AAA44930.132827 l|gb|AAA44927.1328265|gb|AAA44924.1328259|gb|AAA44921.1328252|gb|AAA44917.1328244|gb|AAA44914.1328236|gb|AAA44910.1328230|gb|AAA44907.1328224|gb|AAA44904.1328218|gb|AAA44901.1328212|gb|AAA44898.1328206|gb|AAA44895.1328198|gb|AAA44891.1328192|gb|AAA44888.1328183 |gb|AAA44884.1328175|gb|AAA44880.1

328169|gb| AAA44877.182319758|sp|Q9QND4|Q9QND4_9HIVl,82308357|sp|Q9YV21 |Q9YV21_9HIV1,82307897|sp|Q9WPY2|Q9WPY2_9HIVl,82307895|sp|Q9WPY0|Q9WPY0_9HIVl,82307893|sp|Q9WPX8|Q9WPX8_9HIVl,82307891|sp [Q9WPX61Q9 WPX6_9HIV 1,82307889|sp|Q9WPX4|Q9WPX4_9HIVl,82307887|sp|Q9WPX2|Q9WPX2_9HIVl,82307885|sp|Q9WPX0|Q9WPX0_9HIVl,823 07883 |sp|Q9WPW8 |Q9 WP W8_9HTV 1,82307881 |sp|Q9 WPW6 |Q9 WP W6_9HIV 1,82307879|sp|Q9WPW4|Q9WPW4_9HIVl,82307877|sp|Q9WPW2|Q9WPW2_9HIVl,82307875|sp|Q9WPW0|Q9WPW0_9HIVl,82307873|sp|Q9WPV8|Q9AVPV8_9HIVl,

|328372|gb| AAA44977.11|328366|gb|AAA44974.1||328360|gb|AAA44971.1 j|328354|gb|AAA44968.1||328348|gb|AAA44965.11|328342|gb|AAA44962.11|328336|gb|AAA44959.1||328330|gb|AAA44956.1||328324|gb|AAA44953.1||328318|gb|AAA44950.1 j|328312|gb|AAA44947.1||328306|gb|AAA44944.1||328300|gb|AAA44941.1||328294|gb|AAA44938.11|328288|gb|AAA44935.1 j|328282|gb|AAA44932.1||328276|gb|AAA44929.1|328269jgbjAAA44926.1Í3282Õ3 jgb jAAA44923.1|328257|gb|AAA44920.1|328250|gb|AAA44916.1|328242|gb| AAA44913.1|328234|gb|AAA44909.1|328228|gb|AAA44906.1|328222|gb|AAA44903.1|328216|gb|AAA44900.1|328210|gb|AAA44897.1|328204|gb|AAA44894.1|328196|gb|AAA44890.1|328190|gb|AAA44887.1|328179|gb|AAA44882.1|328173 jgbj AAA44879.1|328167|gb|AAA44876.1

|328370|gb|AAA44976.1||328364|gb|AAA44973.1||328358|gb|AAA44970.1||328352|gb|AAA44967.1 j|328346|gb| AAA44964.11|328340|gb|AAA44961.1||328334|gb|AAA44958.1||328328|gb|AAA44955.1||328322|gb|AAA44952.11|328316|gb|AAA44949.1||328310|gb|AAA44946.1 j|328304|gb|AAA44943.1||328298|gb|AAA44940.1||328292|gb|AAA44937.1||328286|gb|AAA44934.11|328280|gb| AAA44931.il|328274|gb|AAA44928.1||328267|gb|AAA44925.1|

hiooílLl.1» A A A /IQOO 11

|328255|gb|AAA44919.lj|328246|gb|AAA44915.1||328238|gb|AAA44911.1||328232|gb|AAA44908.1||328226|gb|AAA44905.1|328220|gb| AAA44902.1|328214|gb|AAA44899.1|328208|gb|AAA44896.1|328200|gb|AAA44892.1|328194|gb|AAA44889.1|328185|gb|AAA44885.1|328177|gb|AAA44881.1|328171|gb|AAA44878.1|328165|gb|AAA44875.1|82312470|sp|Q89842|Q89842_9HTVl|82307898|sp|Q9WPY3|Q9WPY3_9HIVl|82307896|sp|Q9WPYl|Q9WPYl_9HIVl|82307894|sp|Q9WPX9|Q9WPX9_9HrVl|82307892|sp|Q9WPX7|Q9WPX7_9HIVl|82307890|sp|Q9WPX5|Q9WPX5_9HIVl|82307888|sp|Q9WPX3|Q9WPX3_9HTVl|82307886|sp|Q9WPXl |Q9WPX1_9HIV1|82307884]sp|Q9WPW9|Q9WPW9_9HIVl|82307882|sp|Q9WPW7|Q9WPW7_9HIVl|82307880|sp|Q9WPW5|Q9WPW5_9HIVl|82307878|sp|Q9WPW3|Q9WPW3_9HIVl|82307876|sp|Q9WPWl|Q9WPWl_9HTVl|82307874|sp|Q9WPV9|Q9WPV9_9HIVl|82307872|sp|Q9WPV7|Q9WPV7_9HIVl82307871|sp|Q9WPV6|Q9WPV6_9HIVl,

82307869|sp|Q9 WP V4 |Q9 WPV4_9HIV 1,

82307867|sp|Q9WPV2|Q9WPV2_9HIVl,

823O7865|sp|Q9WPV0|Q9WPV0_9HIVl,

82307863|sp|Q9WPU8|Q9WPU8_9HIVl,

82307861 |sp|Q9WPU6|Q9WPU6_9HIVl,

82307859|sp|Q9WPU4|Q9WPU4_9HIVl,

82307857|sp|Q9WPU2|Q9WPU2_9mVl,

82307855|sp|Q9WPU0|Q9WPU0_9HIVl,

82307853|sp|Q9WPT8|Q9WPT8_9HIVl,

82307851|sp|Q9WPT6|Q9WPT6_9HIVl,

82307849|sp|Q9WPT4|Q9WPT4_9EQYl,

82307847|sp|Q9WPT2|Q9WPT2_9HIVl,

82307845 |sp|Q9WPT0|Q9WPT0_9HIVl,

82307843|spjQ9WPS8|Q9WPS8_9HIVl,

82307841 |sp|Q9WPS6|Q9WPS6_9HIVl,

82306563|sp|Q9QNFl|Q9QNFl_9HIVl,

82306561 |sp]Q9QNE9|Q9QNE9_9HIVl,

82306559|sp|Q9QNE7 jQ9QNE7_9HTv 1,

82306557|sp|Q9QNE5|Q9QNE5_9HIVl3

82306555 |sp|Q9QNE2|Q9QNE2_9HIVl,

82306553|sp|Q9QNE0|Q9QNE0_9HIVl,

82306551|sp|Q9QND8|Q9QND8_9HIVl,

82306549|sp|Q9QND6|Q9QND6_9HIVl,

82306547jsp|Q9QND3|Q9QND3_9HIVl,

82306545]sp]Q9QNDl|Q9QNDl_9HIVl,

82306543|sp|Q9QNC9]Q9QNC9_9HIVl,

82306539|sp|Q9QN68|Q9QN68_9HIVl,

82306537|sp|Q9QN66|Q9QN66_9HIVl3

82306535|sp|Q9QN64|Q9QN64_9HIVl,

82306533|sp|Q9QN62|Q9QN62_9HIVl,

8230653 l|sp|Q9QN60|Q9QN60_9HIVl,

82306529|sp|Q9QN58|Q9QN58_9HIVl,

82306527|spjQ9QN56|Q9QN56_9HIVl,

82305567|sp|Q9PX46|Q9PX46_9HIVl,

82305560|sp |Q9PX02|Q9PX02_9HIV 1,

82305558]sp|Q9PWZ8|Q9PWZ8_9HIVl,

82297264|sp|Q8 J5P1 |Q8 J5P 1_9HIV 1,

82297262|sp|Q8J5N9|Q8J5N9_9HIVl,

82297260|sp|Q8J5N7|Q8J5N7_9HIVl,

82297258|sp]Q8J5N5|Q8J5N5_9HIVl,

82297256jsp)Q8J5N3|Q8J5N3_9HIVl5

82297254|sp|Q8 J5N1 |Q8 J5N1_9HIV1,

82297252|sp|Q8J5M9|Q8J5M9_9HIVl5

82297250|sp|Q8J5M7]Q8J5M7_9HIVl,

82297248|sp|Q8J5M5|Q8J5M5_9HIVl,

82297246| sp |Q8 J5M3 |Q8 J5M3_9HTV 1,

82297244|sp|Q8J5Ml|Q8J5Ml_9HIVl,

|82307870|sp|Q9WPV5|Q9WPV5_9HIVl|82307868|sp|Q9WPV3|Q9WPV3_9HIVl|82307866|sp|Q9WPVl|Q9WPVl_9HIVl|82307864|sp|Q9WPU9|Q9WPU9_9HIVl|82307862|sp|Q9WPU7|Q9WPU7_9HIVl|82307860|sp|Q9WPU5|Q9WPU5_9HIVl|82307858|sp|Q9WPU3|Q9WPU3_9HrVl|82307856|sp|Q9WPUl|Q9WPUl_9HrVl|82307854|sp|Q9WPT9|Q9WPT9_9HIVl|82307852|sp|Q9WPT7|Q9WPT7_9HIVl|82307850|sp|Q9WPT5|Q9WPT5_9HIVl|82307848|sp|Q9WPT3|Q9WPT3_9HIVl|82307846|sp|Q9WPTl|Q9WPTl_9HIVl|82307844|sp|Q9WPS9|Q9WPS9_9HIVl|82307842|sp|Q9WPS7|Q9WPS7_9HIVl|82307840|sp|Q9WPS5|Q9WPS5_9HIVl|82306562|sp|Q9QNF0|Q9QNF0_9HIVl|82306560|sp|Q9QNE8)Q9QNE8_9HTVlj82306558jsp|Q9QNE6 |Q9QME6_9HIV 1|82306556|sp|Q9QNE3|Q9QNE3_9HIVl|82306554|sp|Q9QNEl|Q9QNEl_9HIVl|82306552|sp|Q9QND9|Q9QND9_9HIVl|82306550|sp|Q9QND7|Q9QND7_9HIVl|82306548|sp|Q9QND5|Q9QND5_9fflVl|82306546|sp|Q9QND2|Q9QND2_9mVl|82306544|sp|Q9QND0|Q9QND0_9HIVl|82306542|sp|Q9QNC8|Q9QNC8_9HIVl|82306538|sp|Q9QN67|Q9QN67_9HTVl|82306536|sp|Q9QN65|Q9QN65_9HIVl|82306534|sp|Q9QN63|Q9QN63_9HIVl|82306532|sp|Q9QN61|Q9QN61_9HTVl|82306530|sp|Q9QN59|Q9QN59_9HIVlÍ82306528|sp|Q9QN57|Q9QN57_9HIVl|82306526|sp|Q9QN55|Q9QN55_9HIVl|82305565|sp|Q9PX21|Q9PX21_9HTVlÍ82305559|sp|Q9PXOO|Q9PXOO_9HIVl|82297265|sp |Q8 J5P2|Q8 J5P2_9HIV 1|82297263 |sp]Q8J5PO|Q8J5PO_9HTVl|82297261|sp|Q8J5N8|Q8J5N8_9HTVl|82297259|sp|Q8J5N6|Q8J5N6_9HrVl|82297257|sp|Q8J5N4|Q8J5N4_9HTVl|82297255|sp|Q8J5N2|Q8J5N2_9HTVl|82297253|sp|Q8J5N0|Q8J5N0_9HIVl|8229725 l|sp|Q8J5M8|Q8J5M8_9HIVl|82297249|sp|Q8J5M6)Q8J5M6_9HIVl|82297247|sp|Q8J5M4|Q8J5M4_9HIVl|82297245|sp|Q8J5M2|Q8J5M2_9HIVl|82297243|sp|Q8J5M0|Q8J5M0_9HrVl82297242|sp|Q8J5L9|Q8J5L9_9fflVl,

82297240|sp|Q8J5L7|Q8J5L7_9fflVl,

82297238|sp|Q8J5L5 |Q8 J5L5_9HIV1,

82297236|sp|Q8J5L3|Q8J5L3_9fflVl,

82297234|sp|Q8 J5L1 |Q8 J5L1_9HIV 1,

82297232|sp|Q8J5K9|Q8J5K9_9HIVl,

82297230|sp|Q8J5K7|Q8J5K7_9HIVl,

82297228|sp|Q8J5K5|Q8J5K5_9HIVl,

82297226|sp|Q8J5K3|Q8J5K3_9HrVl,

82297224 sp|Q8 J5K1 |Q8 J5K1_9HIV1,

82297222jsp|Q8J5J9|Q8J5J9_9mVl,

82297220|sp|Q8J5J7|Q8J5J7_9HIVl,

82297218|sp|Q8J5J5|Q8J5J5_9H[Vl,

82297216|sp|Q8 J5 J3 |Q8 J5 J3_9HIV1,

82297214|sp|Q8J5Jl|Q8J5Jl_9HIVl,

82297212|sp|Q8J5I9|Q8J5I9_9HrVl,

82297210|sp|Q8J5I7|Q8J5I7_9HIVl,

82297208|sp|Q8J5I5|Q8J5I5_9HIVl,

82297206|sp|Q8J5D|Q8J5D_9HIVl,

82297204|sp|Q8J5Il|Q8J5Il_9HIVl,

82297202|sp|Q8J5H9|Q8J5H9_9HIVl,

82297200|sp|Q8J5H7|Q8J5H7_9HIVl,

82297198|sp|Q8J5H5|Q8J5H5_9HIVl,

82297196|sp|Q8J5H3|Q8J5H3_9HIVl,

82297194]sp|Q8J5Hl|Q8J5Hl_9EQYl,

82297192|sp|Q8J5G9|Q8J5G9_9HIVl,

82297190|sp|Q8J5G7|Q8J5G7_9HIVl,

82297188|sp|Q8J5G5|Q8J5G5_9fflVl,

82297186|sp|Q8J5G3|Q8 J5G3_9HIV15

82297184|splQ8J5Gl|Q8J5Gl_9HIVl,

82297182|sp|Q8 J5F9|Q8 J5F9_9HIV1,

82297180|sp|Q8J5F7|Q8J5F7_9HIVl,

82297178jsp |Q8 J5F5 |Q8 J5F5_9HIV 1,

82297176|sp|Q8 J5F3 |Q8 J5F3_9HTV1,

82297174|sp|Q8J5Fl|Q8J5Fl_9HIVl,

82297172|sp|Q8J5E9|Q8J5E9_9fflVl,

82297170|sp|Q8J5E7jQ8J5E7_9HIVl5

82297168|sp|Q8J5E5|Q8J5E5_9HIVl,

82297166|sp|Q8J5E3|Q8J5E3_9HIVl,

82297164|sp|Q8J5El|Q8J5El_9HTVl,

82297162|sp|Q8J5D9|Q8J5D9_9mVl5

82297160|sp|Q8J5D7|Q8J5D7_9HIVl,

82297158|sp|Q8J5D5|Q8J5D5_9HIVl5

82297156|sp|Q8J5D3|Q8J5D3_9HIVl,

82297154|sp|Q8J5Dl|Q8J5Dl_9inVl,

82297152|sp|Q8J5C9|Q8J5C9_9HIVl,

82297150|sp|Q8J5C7|Q8J5C7_9HIVl,

82297148|sp|Q8 J5C5 |Q8 J5C5_9HIV1,

|82297241 |sp|Q8J5L8|Q8J5L8_9HIVl|82297239|sp|Q8J5L6|Q8J5L6_9HIVl|82297237|sp|Q8J5L4|Q8J5L4_9HIVl|82297235|sp|Q8J5L2|Q8J5L2_9HIVl|82297233|sp|Q8J5L0|Q8J5L0_9fflVl|82297231 |sp|Q8 J5K8 |Q8 J5K8_9HIV1|82297229|sp|Q8J5K6|Q8J5K6_9HIVl|82297227|sp|Q8J5K4|Q8J5K4_9H]iVl|82297225|sp|Q8J5K2|Q8J5K2_9fflVl|82297223|sp|Q8J5K0|Q8J5K0_9fflVl|82297221 |sp|Q8J5J8|Q8J5J8_9HIVl|82297219|sp|Q8J5J6|Q8J5J6_9mVl|82297217|sp|Q8J5J4|Q8J5J4_9HIVl|82297215|spÍQ8J5J2jQ8J5J2_9fflVl|82297213|sp)Q8J5J0|Q8J5J0_9HIVl|82297211 |sp|Q8J5I8|Q8J5I8_9HIVl|82297209|sp|Q8J5I6|Q8J5I6_9HIVl|82297207|sp|Q8J5I4|Q8J5I4_9inVl|82297205|sp|Q8 J5I2ÍQ83 5I2_9fflV 1|82297203|sp|Q8J5I0|Q8J5I0_9fflVl|82297201|sp|Q8J5H8|Q8J5H8_9HTVl|82297199|sp|Q8J5H6|Q8J5H6_9HIVl|82297197|sp|Q8J5H4|Q8J5H4_9HIVl|82297195|sp|Q8J5H2|Q8J5H2_9HIVl|82297193|sp|Q8J5HO|Q8J5HO_9HIVl|82297191 |sp|Q8J5G8|Q8J5G8_9HIVl|82297189|sp|Q8J5G6|Q8J5G6_9EQVl|82297187|sp|Q8J5G4|Q8J5G4_9HIVl|82297185 |sp|Q8 J5G2|Q8 J5G2_9HIV1|82297183|sp|Q8J5G0|Q8J5G0_9HIVl|82297181 |sp|Q8J5F8|Q8 J5F8_9HIV1|82297179|sp|Q8 J5F6|Q8 J5F6_9HIV 1|82297177|sp|Q8J5F4|Q8J5F4_9HIVl|82297175 |sp|Q8J5F2|Q8J5F2_9HIVl|82297173|sp|Q8J5F0]Q8J5F0_9HIVl|82297171|sp|Q8J5E8|Q8J5E8_9HIVl|82297169|sp|Q8J5E6|Q8J5E6_9HIVl|82297167|sp|Q8J5E4|Q8J5E4_9HIVl|82297165|sp|Q8J5E2|Q8J5E2_9HIVl|82297163 |sp|Q8J5E0|Q8J5E0_9HIVl|82297161|sp|Q8J5D8|Q8J5D8_9HIVl|82297159|sp|Q8J5D6|Q8J5D6_9HTVl|82297157|sp|Q8J5D4|Q8J5D4_9HIVl|82297155|sp|Q8J5D2|Q8J5D2_9HIVl|82297153|sp|Q8J5D0|Q8J5D0_9HIVl|82297151|sp|Q8J5C8|Q8J5C8_9HIVl|82297149|sp|Q8J5C6|Q8J5C6_9HIVl|82297147|sp|Q8J5C4|Q8J5C4_9HIVl|82297146|sp|Q8J5C3|Q8J5C3

|82297144|sp |Q8 J5 C1 |Q8 J5C1

|82297142|sp|Q8J5B9|Q8J5B9

|82297140|sp|Q8J5B7|Q8J5B7

|8229713 8 |sp|Q8 J5B5 |Q8 J5B5

|82297136|sp|Q8 J5B3 |Q8 J5B3

|82297134|sp|Q8 J5B1 |Q8 J5B1

|82297132|sp|Q8J5A9|Q8J5A9

|82297130|sp|Q8J5A7|Q8J5A7

|82297128|sp|Q8J5A5|Q8J5A5

|82297126|sp|Q8J5A3|Q8J5A3

|82297124|sp|Q8 J5 Al |Q8 J5 Al

|82297122|sp|Q8 J599|Q8 J599J

|82297120|sp|Q8J597|Q8J597

|82297118|sp|Q8 J595|Q8 J595

|82297116|sp|Q8J593|Q8J593_!

|82297114|sp|Q8 J591 |Q8 J591J

|82297112|sp|Q8J589|Q8J589

|82297110|sp|Q8J587|Q8J 587

|82297108|sp|Q8J585|Q8J585

|82296833|sp|Q8J318|Q8J318

|82296831 |sp|Q8 J314|Q8 J314^

|82295 87 l|sp|Q8AU8|Q8A[J8_

|82295353|sp|Q89888|Q89888

|82295349|sp|Q89851|Q89851

|82295346|sp|Q89821|Q89821

|82295343 |sp|Q89758|Q89758

|82295340|sp|Q89706|Q89706

|82295338|sp|Q89672|Q89672

|82295335|sp|Q89646|Q89646

|82295333|sp|Q89629|Q89629

|82295326|sp|Q89587|Q89587

|82295324|sp|Q89575|Q89575

|82295318|sp|Q89515|Q89515

|82295314|sp|Q89463|Q89463

|82295312|sp|Q89436|Q89436

|82291329|sp|Q79785|Q79785

|82291327|sp|Q79783|Q79783

|82291325 |sp|Q79781|Q79781

|82291323|sp|Q79779|Q79779

|82291321 |sp|Q79777|Q79777

|82291319|sp|Q79775|Q79775

|82291317|sp|Q79773|Q79773

|82291315 |sp|Q79771 |Q79771

|82291313|sp|Q79769|Q79769

|82291311|sp|Q79767|Q79767

|82291309|sp|Q79765|Q79765

|82291307|sp|Q79763|Q79763

9HTV1,9HIV1,9HIV1,9HIV1,9HIV1,9HIV1,9HIV1,9HIV1,9HTV1,i_9HIVl,I9HIV1,9HIV1,9HIV1,9HIV1,9HTV1,9HTV1,9HIV1,9HIV1,9HTVÍ,9HIV1,9HIV1,9HIV1,

9HIV1 trancada,19HIV1,9HIV1,9HTV1,9HIV1,_9HTV1,9HIV1,9HIV1,9HIV1,9HIV1,9HIV1,9BQV1,_9HIV1,9HTV1,9HTV1,í_9HIVl,9HIV1,»_9HIV1,r_9HIVl,i_9fflVl,i_9HIVl,_9HIV1,9HIV1,'_9HIV1,:_9HIV1,i_9HIYl,

|82297145|sp|Q8J5C2|Q8J5C2_9HIVl,|82297143|sp|Q8 J5C0|Q8 J5C0_9HTV1,|82297141|sp|Q8J5B8|Q8J5B8_9HTVl,|82297139|sp|Q8J5B6|Q8J5B6_9fflVl,|82297137|sp|Q8J5B4|Q8J5B4_9HTVl,|82297135|sp|Q8J5B2|Q8J5B2_9HrVl,|82297133|sp|Q8J5B0|Q8J5B0_9HTVl,|82297131|sp|Q8J5A8|Q8J5A8_9HTVl,|82297129|sp|Q8J5A6|Q8J5A6_9HTVl,|82297127|sp|Q8J5A4|Q8J5A4_9HTVl,|82297125|sp|Q8J5A2|Q8J5A2_9IHVl,|82297123|sp |Q8 J5 A0|Q8 J5 A09HIV 1,|82297121|sp|Q8J598|Q8J598_9HIVl,|82297119|sp|Q8J596|Q8J596_9HIVl,|82297117|sp|Q8J594|Q8J594_9HTVl,|82297115|sp|Q8J592|Q8J592_9HTVl)|82297113|sp|Q8J590|Q8J590_9HIVl,|82297111|sp|Q8J588|Q8J588_9HTVl,

λλι___lAotfOílAOTCOC ΟΤΤΤΛΠ

/ iu>jsp|voj Jou|yujjou_^iü » χ,

|82297107|sp |Q8 J5 84|Q8 J5 84_|82296832|sp|Q8J315|Q8J315_|82296830|sp|Q8J313|Q8J313_|82295354|sp|Q89889|Q89889_|82295350|sp|Q89866|Q89866_|82295348|sp|Q89844|Q89844_|82295345|sp|Q89778|Q89778_|82295341 |sp|Q89734|Q89734_|82295339|sp|Q89688|Q89688_|82295337|sp|Q89668|Q89668_|82295334|sp|Q89630|Q89630_|82295332|sp|Q89623|Q89623|82295325|sp|Q89586|Q89586_|82295320|sp|Q89537|Q89537|82295317|sp|Q89511 |Q89511_|82295313 |sp|Q8943 8|Q8943 8_|82295311 |sp|Q89430|Q89430_|82291328|sp|Q79784|Q79784.|82291326|sp|Q79782|Q79782|82291324|sp|Q79780|Q79780_|82291322|sp|Q79778|Q79778|82291320|sp|Q79776|Q79776|82291318|sp|Q79774|Q79774|82291316|sp|Q79772|Q79772|82291314|sp|Q79770|Q79770.|82291312|sp|Q79768|Q79768|82291310|sp|Q79766|Q79766|82291308|sp|Q79764|Q79764|82291306|sp|Q79762|Q79762

9HIV1,9HIV1,9HTV1,9HTV1,9HTV1,9HTV1,9HTV1,9HTV1,9HTV1,9HIV1,9HIV1,9HIV1,9HIV1,9HIV1,9HTV1,9HIV1,9HTV1,_9fflVl,9HIV1,9HTV1,9HIV1,9HIV1,9HTV1,9HIV1,9HIV1,9HTV1,9HTV1,9HIV1,9HIV1,82291305|sp|Q79761|Q79761_9HIVl82291303|sp|Q79759|Q79759_9HIVl82291301|sp|Q79757|Q79757_9HIVl82291299|sp|Q79755|Q79755_9HIVl82291297|sp|Q79753|Q79753_9mVl82291295|sp|Q79751|Q79751_9HIVl82291293|sp|Q79749|Q79749_9HIVl82291291|sp|Q79747|Q79747_9fflVl82291289|sp|Q79745|Q79745_9HIV182291287|sp|Q79743|Q79743_9HIVl82291285|sp|Q79741|Q79741_9HIVl82291283 |sp|Q79739|Q79739_9HIVl82291281|sp|Q79737|Q79737_9HIVl82291279|sp|Q79735|Q79735_9HIVl82291277|sp|Q79733|Q79733_9HrVl82291275|sp|Q79731 |Q79731_9HIV182291273|sp|Q79727|Q79727_9HIVl82291271 jsp|Q79725 |Q79725_9HIV182291269|sp|Q79722]Q79722_9HlVÍ82291267|sp|Q79720|Q79720_9HIVl82291265|sp|Q79718|Q79718_9HIVl82291263|sp|Q79716|Q79716_9HIVl82291261 jsp|Q79714|Q79714_9B0TVrl82291259|sp|Q79712|Q79712_9HIVl82291257|sp|Q79710)Q79710_9HIVl82291255|sp|Q79708|Q79708_9HIVl82291253|sp|Q79706|Q79706_9HIVl82291251 |sp|Q79704|Q79704_9HIV 182291249|sp|Q79702|Q79702_9HIVl82291246|sp|Q79699|Q79699_9HIVl82291244|sp|Q79697]Q79697_9HTVl82291242|sp|Q79695|Q79695_9HTVl82291240|sp|Q79693|Q79693_9HIVl82291238|sp|Q79691|Q79691_9HIVl82291236|sp|Q79689|Q79689_9HIVl82291234|sp|Q79687|Q79687_9HIVl8229123 ljsp|Q79684|Q79684_9HIVl82291228|sp|Q79681|Q79681_9HIVl82291226|sp|Q79678|Q79678_9HIVl82291224|sp|Q79676|Q79676_9HIVl82291222|sp|Q79674|Q79674_9HIVl82289471|sp|Q74688|Q74688_9HIVl82289469|sp|Q74686jQ74686_9HIVl82289467|sp|Q74684|Q74684_9HIVl82289465|sp|Q74682|Q74682_9HIVl82289463|sp|Q74680|Q74680_9HIVl82289461|sp|Q74678|Q74678_9HIVl82289459|sp|Q74676|Q74676_9HIVl

|82291304|sp|Q79760|Q79760_9HIVl|82291302|sp|Q79758|Q79758_9HIVl|82291300|sp|Q79756|Q79756_9HIVl|82291298|sp|Q79754|Q79754_9fflVl|82291296|sp|Q79752|Q79752_9fflVl|82291294|sp|Q79750|Q79750_9fflVl|82291292|sp|Q79748|Q79748_9HIVl|82291290|sp|Q79746|Q79746_9HIVl|82291288|sp|Q79744|Q79744_9HIVl|82291286|sp|Q79742|Q79742_9HIVl|82291284|sp|Q79740|Q79740_9fflVl|82291282|sp|Q7973 8|Q7973 8_9HIV 1|82291280|sp|Q79736|Q79736_9HIVl|82291278|sp|Q79734|Q79734_9HIVl|82291276|sp|Q79732|Q79732_9HIVl|82291274|sp|Q79730|Q79730_9fflVl|82291272|sp|Q79726|Q79726_9HIVl|82291270|sp|Q79724|Q79724_9fflVlj8229i268jspiQ7972ijQ7972Í_3KTvTl|82291266|sp|Q79719|Q79719_9HIV1|82291264|sp]Q79717|Q79717_9HIV1j82291262|sp|Q79715 |Q79715_9HIV 1|82291260|sp|Q79713 |Q79713_9HIV 1|82291258|sp|Q79711|Q79711_9HIVl|82291256|sp|Q79709|Q79709_9HIVl|82291254|sp|Q79707|Q79707_9HrVl|82291252|sp|Q79705|Q79705_9HIVl|82291250|sp|Q79703|Q79703_9HrVl|82291248|sp|Q79701|Q79701_9HIVl|82291245|sp|Q79698|Q79698_9HIVl|82291243|sp|Q79696|Q79696_9HIVl|82291241 jsp|Q79694|Q79694_9fflVl|82291239|sp|Q79692|Q79692_9HIVl|82291237)sp|Q79690|Q79690_9HIVl|82291235|sp|Q79688|Q79688_9HIVl|82291232|sp|Q79685|Q79685_9HIVl|82291230|sp|Q79683|Q79683_9HIVl|82291227|sp|Q79680|Q79680_9HIVl|82291225|sp|Q79677|Q79677_9HIVl|82291223|sp|Q79675|Q79675_9HIVl|82291221 |sp|Q79673|Q79673_9HTVl|82289470|sp|Q74687|Q74687_9HTVl|82289468|sp|Q74685|Q74685_9HIVl|82289466|sp|Q74683|Q74683_9HIVl|82289464|sp|Q74681 |Q74681_9HIV 1|82289462|sp|Q74679|Q74679_9HIVl|82289460|sp |Q74677|Q74677_9HIV 1182289458|sp |Q74675|Q74675_9HIV 182288766|sp|Q72481|Q72481_9fflVl,

82288764|sp|Q72479|Q72479_9HIVl,

82288762|sp|Q72477|Q72477_9fflVl,

82288760|sp|Q72475 |Q72475_9HIV1,

82288758|sp|Q72473|Q72473_9HIV 1,

82288756|sp|Q72471 |Q72471_9HIV1,

82288754|sp|Q72469|Q72469_9HIVl,

82288752|sp|Q72467|Q72467_9fflVl,

82288750|sp|Q72465|Q72465_9mVl,

82288748|sp|Q72463|Q72463_9HQYl,

82288746|sp|Q72461|Q72461_9HIVl,

82288744|sp|Q72459|Q72459_9MVl,

82288742|sp|Q72457|Q72457_9HIVl,

82288740|sp|Q72455|Q72455_9EQVl,

82288738|sp]Q72453|Q72453_9HIVl,

82288736|sp|Q72451|Q72451_9HIVl,

82288734|sp|Q72449|Q72449_9HIVl,

82288732|sp|Q72447|Q72447_9HIVl,

82288730|sp|Q72445|Q72445_9HIVl,

82288728|sp|Q72443|Q72443_9HIVl,

82288726|sp|Q72441|Q72441_9HIVl,

82288724|sp|Q72439|Q72439_9HrVl,

82288722|sp|Q72437|Q72437_9HIVl,

82288720|sp|Q72435|Q72435_9HIVl,

82288718|sp|Q72432|Q72432_9HIVl,

82288716|sp|Q72430|Q72430_9HIVl,

82288714|sp|Q72427|Q72427_9HIVl,

82288712|sp|Q72425|Q72425_9HIVl,

82288710|sp)Q72423|Q72423_9HTVl,

82288708|sp|Q72421|Q72421_9HIVl,

82288706|sp|Q72419|Q72419_9HIVl,

82288494|sp|Q71184|Q71184_9HIVl,

82288492|sp|Q71182|Q71182_9HIVl,

82288490|sp|Q71180|Q71180_9HIV1,

82288488|sp|Q71178|Q71178_9fflVl,

82288486|spjQ71176|Q71176_9HIVl,

82288484|sp|Q71174|Q71174_9HIV1,

82288482|sp|Q71172|Q71172_9HIV1,

82288480|sp|Q71170|Q71170_9HIVl,

82288478|sp|Q71168|Q71168_9HIV15

82288476|sp|Q71166|Q71166_9HIV1,

82288474|sp|Q71164|Q71164_9HIV15

82288472|sp|Q71162|Q71162_9HIV1,

82288470|sp|Q71160|Q71160_9HIV15

82283482|sp|Q5Y3C4|Q5Y3C4_9HIVl,

82283480|sp|Q5Y3C2|Q5Y3C2_9HIVl,

82283478|sp|Q5Y3C0|Q5Y3C0_9HIVl,

82283476|sp|Q5Y3B8|Q5Y3B8_9HIVl,

|82288765|sp|Q72480|Q72480_9HIVl|82288763|sp|Q72478|Q72478_9HIVl182288761 |sp|Q72476|Q72476_9HIVl|82288759|sp|Q72474|Q72474_9HIVl18228875 7|sp |Q72472|Q72472_9HIV 1|82288755|sp|Q72470|Q72470_9HIVl|82288753|sp|Q72468|Q72468_9HIVl18228875 l|sp|Q72466|Q72466_9fflVl|82288749|sp|Q72464|Q72464_9HIVl|82288747|sp|Q72462|Q72462_9HIVl|82288745 |sp|Q72460|Q72460_9HIV 1|82288743jsp |Q7245 8|Q7245 8_9HIV 1|82288741|sp|Q72456|Q72456_9HTVl|82288739|sp|Q72454|Q72454_9HIVl|82288737|sp|Q72452|Q72452_9HIVl|82288735|sp|Q72450|Q72450_9HIVl|82288733|sp|Q72448|Q72448_9HIVl|8228873 l|spjQ72446|Q72446_9HIVl|82288729ispiQ72444jQ72444_9Hrv 1|82288727|sp|Q72442|Q72442_9HIVl|82288725|sp|Q72440|Q72440_9HIVl|82288723|sp]Q72438|Q72438_9HIVl|8228872 l|sp|Q72436|Q72436_9HIVl|82288719|sp|Q72433|Q72433_9HIVl|82288717|sp|Q72431 |Q72431_9HIV 1|82288715|sp|Q72429|Q72429_9HIVl|82288713|sp|Q72426|Q72426_9HrVl|8228871 l|sp|Q72424|Q72424_9HIVl|82288709|sp]Q72422]Q72422_9HIVl|82288707|sp|Q72420|Q72420_9HIVl|82288495|sp|Q71185|Q71185_9HIVl|82288493|sp|Q71183 |Q71183_9HIV1182288491 |sp |Q71181 |Q71181_9HIV 1|82288489|sp|Q71179|Q71179_9HIV1|82288487|sp|Q71177|Q71177_9HIVl|82288485|sp|Q71175|Q71175_9HIV1|82288483|sp|Q71173|Q71173_9HIVl|82288481|sp|Q71171|Q71171_9HIVl|82288479|sp|Q71169|Q71169_9HIVl|82288477|sp|Q71167|Q71167_9HIV1|82288475|sp|Q71165|Q71165_9HTVl|8228 8473 |sp|Q71163 |Q71163_9HIV 1|82288471jsp|Q71161|Q71161_9HIVl|82283483|sp|Q5Y3C5|Q5Y3C5_9HTVl|8228348 l|sp|Q5Y3C3|Q5Y3C3_9HIVl|82283479|sp|Q5Y3Cl|Q5Y3Cl_9HrVl|82283477|sp|Q5Y3B9|Q5Y3B9_9HIVl|82283475|sp|Q5Y3B7|Q5Y3B7__9HIVl82283474|sp|Q5Y3B6|Q5Y3B6_9HIVl,

82283472|sp|Q5Y3B4|Q5Y3B4_9HIVl,

82283470|sp|Q5Y3B2|Q5Y3B2_9HIVl,

82283468|sp|Q5Y3B0|Q5Y3B0_9HIVl,

82283466|sp|Q5Y3A8|Q5Y3A8_9HIVl,

82283464|sp|Q5Y3A6|Q5Y3A6_9HTVl5

82283462|sp|Q5Y3A4|Q5Y3A4_9HIVl,

82283460|sp|Q5Y3A2|Q5Y3A2_9HIVl,

82283458|sp|Q5Y3A0|Q5Y3A0_9HIVl,

82283456|sp|Q5Y397|Q5Y397_9HIVl,

82283454|sp|Q5Y395|Q5Y395_9HIVl,

82283452|spiQ5Y393|Q5Y393_9mVl,

82281075jsp|092654|092654_9HIVl,

82280705|sp|091043|091043_9HIVl,

82280703|sp|091041|091041_9HIVl,

82280701 |sp|091039|091039_9HIVl,

82280699|sp|091037|091037_9fflVl,

82280697|sp|091035|091035_9mVl,

82280695|5ρ|091033|091033_9Ηΐνΐ,

82280693 |sp|091031|091031_9HIVl,

82280691 |sp|091029|091029_9HIVl,

82280689|sp|091027|091027_9HIVl,

82280687|sp|0910251091025_9fflVl,

82280685 |sp|091023|091023_9HIVl,

82280683|sp|091021|091021_9HIVl,

8228068 ljsp|091019|091019_9HIVl,

82280679|sp|091017|091017_9mVl,

82280677|3ρ|091015|091015_9Ηΐνΐ,

82280675|sp|091013|091013_9fflVl,

82280673|sp|09l011|091011_9HIVl,

82280671|sp|091009|091009_9HIVl,

82280669|sp|091007|091007_9HIVl,

82280667|sp|091005|091005_9ffiVl,

82280665|sp|091003|091003_9HTV 1,

82278699|5ρ|012404|012404_9ΗΓνΐ,

82278098|sp|010843|010843_9HIVl,

82278096|sp|010841|010841_9HrVl,

82278094|sp|010839|010839_9HIVl,

82278092|sp|010837|010837_9HIVl,

82278090|sp|010835|010835_9HIVl,

82278088|sp|010833|010833_9HIVl,

82278086|sp|010831|010831_9HIVl,

82278084|sp|010829|010829_9HIVl,

82278082|sp|010827|010827_9HIVl,

82278080|sp|010825|010825_9HrVl,

82278078|sp|010823|010823_9mVl,

82278076|sp|010820|010820_9HIVl3

82278074|sp|010818|010818_9HIVl,

|82283473|sp|Q5Y3B5|Q5Y3B5_9EQVl|82283471|sp|Q5Y3B3|Q5Y3B3_9HIVl|82283469|sp|Q5Y3Bl|Q5Y3Bl_9HIVl|82283467|sp|Q5Y3A9|Q5Y3A9_9HIVl|82283465|sp|Q5Y3A7|Q5Y3A7_9HIVl|82283463 |sp|Q5Y3A5 |Q5Y3A5_9HIV1|82283461 |sp|Q5Y3A3|Q5Y3A3_9HIVl|82283459|sp|Q5 Y3A1 |Q5Y3 A1_9HIV1|82283457|sp|Q5Y398|Q5Y398_9HTVl|82283455|sp|Q5Y396|Q5Y396_9HIVl|82283453 |sp|Q5Y394|Q5Y394_9HIVl|82281567|sp|P89698|P89698_9HIVl|82280743|sp|091087|091087_9HIVl182280704|sp|0910421091042_9HIV 1|82280702|sp|091040|091040_9HIVl|82280700|sp|0910381091038_9HIV1|82280698|sp|091036|091036_9HIVl|82280696|sp|091034|091034_9HIVl|82280694ispj09l032i091032_9HrvÍ|82280692|sp|091030|091030_9HIVl|82280690|sp|091028|091028_9HIVl|82280688|sp|091026|091026_9HIVl|82280686|sp|091024|091024_9HIVl|82280684|sp|091022|091022_9HIVl|82280682lsp|091020|091020_9HIVl|82280680|sp|091018|091018_9HIVl|82280678|sp|091016|091016_9HIVl|82280676|sp|091014|091014_9HIVl|82280674|sp|091012|091012_9HIVl|82280672|sp|091010|091010_9HIVl|82280670|sp|091008|091008_9HIVl|82280668|sp|091006|091006_9HIVl|82280666|sp|091004|091004_9HIVl|82280509|sp|090156|090156_9HTVl|82278698|sp|012390|012390_9HIVl|82278097|sp|010842|010842_9HIVl|82278095|sp|010840|010840_9HIVl|82278093|sp|010838|010838_9HrVl|82278091|sp|010836|010836_9HIVl|82278089|sp|010834|010834_9HIVl|82278087|sp|010832|010832_9HIVl|82278085|sp|010830|010830_9HIVl|82278083|sp|010828|010828_9EDVl|82278081|sp|010826|010826_9HIVl|82278079|sp|010824|010824_9HIVl|82278077|sp|010822|010822_9HIV1|82278075|sp|010819|010819_9HIVl|82278073|sp|010817|010817_9HTVl|82278072|sp|010816|010816_9HIV1,|82278070|sp|010814|010814_9HIVl,|82278068|sp|010812|010812_9HIVl,|82278066|sp|010810|010810_9HIVl,|82278064|sp|010808|010808_9HIVl,|82278062|sp|010806|010806_9mVl,

|82278071|sp|010815|010815_9fflVl,|82278069|sp|010813|010813_9HIVl,|82278067|sp|010811|010811_9HIVl,|82278065|sp|010809|010809_9HIVl,|82278063|sp|010807|010807_9HIVl,|82278061|sp|010805|010805_9HrVl,

|66864707|gb|AAY57433.1|, |66864699|gb|AAY57426.1|, |66864689|gb|AAY57417.1|,|25167078|gb|AAN73842.1|AF484522_8, |25167068|gb|AAN73833.1|AF484521_8,

|25 l6687Sjgbj AAN73662.1 jAF484502_8tnmcada,|58200357|gb|AAW66381.1|, |58200355|gb|AAW66380.1|,

158200351 |gb|AAW66378.1|,|58200345|gb|AAW66375.1|,|58200339|gb|AAW66372.1|,|58200333|gb|AAW66369.1|,|58200327|gb|AAW66366.1|,|58200321|gb|AAW66363.1|,158200315|gb|AAW66360.11,l58200309jgbjAAW66357.il,|32724981 jgbjAÀM93782.2j, j3 lü87572jgb|AAM93788.1 j,

|58200349|gb|AAW66377.1|,|58200343|gb| AAW66374.11,|58200337|gb|AAW66371.1|,|58200331 |gb|AAW66368.1|,|58200325 |gb|AAW66365.11,|58200319|gb|AAW66362.11,|58200313|gb| AAW66359.1|,]38326776|gb|AAR17518.1|,

|31087567|gb|AAM93786.11,|31087557|gb|AAM93781.lí,|31087547|gb|AAM93778.1 j,131087541 |gb|AAM93775.11,|56193099|gb|AAV84162.1|,|56193048|gb|AAV84135.1|,|54124757|gb|AAV30098.1|,|50404193|gb|AAT76863.1|,|47118258|gb|AATl 1245.1 jtnmcada,|47118238|gb|AATl 1236.1|,|47118218|gb|AATl 1209.1) tnmcada,

|31087563|gb|AAM93784.1|,|31087555|gb|AAM93780.1|,|31087545 |gb|AAM93777.1|,|31087539|gb|AAM93774.1|,|56193083|gb|AAV84153.1|,|56193012|gb|AAV84117.1|,|51599147|gb|AAU08231.1|,

|46451810|gblAAS98022.1|,|46451803|gb| AAS98019.11,|46451796|gb|AAS98016.1|46451790|gb| AAS98013.11,|46451784|gb|AAS98010.11,|46451778|gb|AAS98007.1|,|46451772|gb|AAS98004.11,|46451766|gb|AAS98001.1 j,|46451760|gb|AAS97998.1 j,|46451754|gb| AAS97995.1 j,l46451748lgblAAS97992.ll,|46451741 |gb| AAS97989.11,|46451735|gb|AAS97986.1|,|46451729|gb|AAS97983.1],|46451720|gb|AAS97980.1 j,|46451714|gb | AAS97977.11,|37956596|gb|AA092596.1|,|33641493|gb|AAQ24309.1|,

|46451808|gb| AAS98021.11,|46451801|gb|AAS98018.1|,|46451794|gb|AAS98015.1|,|46451788|gb|AAS98012.1|,|46451782|gb| AAS98009.1|,|46451776|gb| AAS98006.1|,|46451770|gb| AAS98003.11,|46451764|gb|AAS98000.1 j,|46451758|gb|AAS97997.1|,|46451752|gb| AAS97994.11,|46451745|gb|AAS97991.11,|46451739|gb| AAS97988.11,|46451733|gb|AAS97985.1|,|46451726|gb|AAS97982.1|,|46451718|gb|AAS97979.11,|46451710|gb|AAS97975.11,|33641499|gb|AAQ24311.11,|33641491 |gb|AAQ24308.1 j,

|58200359|gb|AAW66382.1|,|58200353|gb|AAW66379.1|,|58200347|gb|AAW66376.1|,|58200341 |gb|AAW66373.11,|58200335|gb|AAW66370.1|,|58200329|gb|AAW66367.1|,|58200323|gb|AAW66364.1|,158200317|gb|AAW66361.1|,|582003 ll|gb|AAW66358.1|,|32724983|gb|AAM93785.2|,

ni noTCTAUUI A λΛίΟ·3787 11

piuo IJI ujsujr^j-lj.rj-x-' . VJ # . i I,

|31087561|gb|AAM93783.1|,|31087549|gb|AAM93779.1 j,|31087543 |gb|AAM93 776.11,|56417612|gb|AAV90750.1|,|56193065|gb|AAV84144.1|,|54124767|gb|AAV30107.11,|51599137|gb|AAU08222.1|,

|47118268|gb|AATl 1254.1 |tnmcada,|47118248|gb|AAT11227.1|tnnicada,|47118228 |gb| AAT11218.1 jtruncada,|46849854|gb|AAS97976.2|,|46451806|gb| AAS98020.1|,|46451799|gb|AAS98017.1|,|46451792|gb|AAS98014.1 j,|46451786|gb| AAS98011.1 j,|46451780|gb|AAS98008.11,|46451774|gb|AAS98005.1|,|46451768|gb| AAS98002.1 j,|46451762|gb| AAS97999.11,|46451756|gb|AAS97996.1|,|46451750|gb | AAS97993.11,|46451743 |gb| AAS97990.11,|46451737|gb|AAS97987.11,|4645173 l|gb|AAS97984.1|,|46451723 |gb|AAS97981.11,(46451716|gb|AAS97978.11,|46451708|gb|AAS97974.1 j,|33641497|gb|AAQ24310.1|5|33641489|gb|AAQ24307.1|,|33641487|gb|AAQ24306.1|

|33641481|gb|AAQ24303.1|

|33641475|gb|AAQ24300.1|

|33641467|gb|AAQ24297.1

|33641461 |gb| AAQ24294.1

|3364l455|gb|AAQ24291.1

|30575565|gb|AAP32904.1|

|30575559|gb|AAP32901.1|

|30575553|gb|AAP32898.1|

|30575542|gb|AAP32894.11

|30575536|gb|AAP32891.1|

|30575529|gb|AAP32888.l!

|30575523|gb|AAP32885.1

|30575517|gb|AAP32882.1

|3057551 l|gb|AAP32879.1

|30575502|gb|AAP32876.1

|30575496|gb|AAP32873.1

|30575490|gb|AAP32870.1

|32261503|gb|AAP76564.1

|32261473|gb|AAP76537.1

|34500808|gb|AAQ73892.1

|34500800|gb|AAQ73889.1

|34500792|gb|AAQ73886.1

|34500786|gb|AAQ73883.1

|34500780|gb|AAQ73880.1

|34500774|gb|AAQ73877.1

|34500768|gb|AAQ73874.1

|34500760|gb|AAQ73 871.1

|34500753|gb|AAQ73868.1

|34500745|gb|AAQ73864.1

|34500736|gb|AAQ73860.1

|34500730|gb|AAQ73857.1

|34500719|gb|AAQ73854.1

|34500713|gb|AAQ73851.1

|34500706|gb|AAQ73848.1

|32724999|gb|AAM93867.2

|32724993|gb|AAM93816.2

|32724987|gb|AAM93795.2

|31087653]gb]AAM93799.1

|31087646|gb|AAM93796.1

|31087636|gb|AAM93791.1

|31087630|gb| AAM93 870.1

|31087622|gb|AAM93 866.1

|31087613|gb|AAM93862.1

|31087490|gb|AAM93836.1

|31087484|gb|AAM93833.1

|31087478|gb|AAM93830.1

|31087472|gb|AAM93827.1

106

|33641485|gb|AAQ24305.1|,|33641479|gb|AAQ24302.1|,|33641473|gb|AAQ24299.1j,|33641465|gb|AAQ24296.1|,|33641459|gb|AAQ24293.1|,|33641452|gb|AAQ24290.1|,|30575563|gb|AAP32903.1|,|30575557|gb|AAP32900.1|,|3057555 l|gb|AAP32897.1|,|30575540|gb|AAP32893.1|,|30575534|gb|AAP32890.1|,|30575527|gb|AAP32887.1|,|30575521|gb|AAP32884.1|,130575515|gb|AAP32881.1|,|30575508|gb|AAP32878.1|,|30575500|gb|AAP32875.1|,|30575494|gb|AAP32872.1|,

|33641483|gb|AAQ24304.1|,

|33641477|gb|AAQ24301.1|,

|33641471 |gb|AAQ24298.11,

|33641463|gb|AAQ24295.1|,

|33641457|gb|AAQ24292.1|,

ll6755651lgblAAL28063.ll,

|30575561|gb|AAP32902.1|,

|30575555|gb|AAP32899.1|,

|30575548|gb|AAP32895.1|,

|30575538|gb|AAP32892.1|,

|30575531|gb|AAP32889.1|,

|30575525|gb|AAP32886.1|,

|30575519|gb|AAP32883.11,

|30575513|gb|AAP32880.1|,

|30575504|gb|AAP32877.1|,

|30575498|gb|AAP32874.1|,

|30575492|gb|AAP32871.11,

' 1> l------I^ I

|32261510|gb|AAP76570.1 jtnmcada,j32261493jgbjAAF76555.1j, !32261483!gb!AAP76546.1|:

|32261457|gb| AAP76522.11,|34500806|gb| AAQ73 891.11,|34500796|gb|AAQ73888.1|,|34500790|gb|AAQ73885.11,|34500784|gb|AAQ73882.1|,|34500778|gb| AAQ73 879.11,|34500772|gb|AAQ73876.1|,|34500766|gb|AAQ73873.1|,|34500758|gb|AAQ73870.1|,|34500751 |gb| AAQ73867.11,|34500740]gb|AAQ73862.1|,|34500734|gb|AAQ73859.1|,|34500724]gb| AAQ73 856.11,|34500717|gb|AAQ73853.1|,|34500710|gb|AAQ73850.1|,|34500704|gb|AAQ73847.1|,|32724997|gb|AAM93864.2|,|32724991 |gb|AAM93805.2|,|32724985|gb| AAM93794.2|,|31087651 |gb|AAM93798.11,|31087640|gb| AAM93793.11,|31087634|gb|AAM93790.1|,|31087628|gb|AAM93869.1|,|31087620|gb| AAM93865.11,|3108761 l|gb|AAM93861.1|,|31087488|gb|AAM93835.1|,|31087482|gb|AAM93832.11,|31087476|gb|AAM93829.11,|31087469|gb| AAM93 826.11,

|34500810|gb|AAQ73893.1|,

|34500803|gb|AAQ73890.1|,

|34500794|gb|AAQ73887.1|,

|34500788|gb|AAQ73884.1|,

|34500782|gb|AAQ73 881.1

|34500776|gb|AAQ73878.1|,

|34500770|gb|AAQ73875.1|,

|34500763|gb|AAQ73872.1|,

|34500755|gb|AAQ73869.1|,

|34500747|gb|AAQ73865.1|,

|34500738|gb|AAQ73861.1|,

|34500732|gb|AAQ73858.1|,

|34500721|gb|AAQ73855.1|,

|34500715|gb|AAQ73852.1|,

|34500708|gb|AAQ73849.1|,

|33359205|gb|AAQ17032.1|,

|32724995|gb|AAM93825.2|,

|32724989|gb|AAM93801.2|,

|3108765 5 |gb|AAM93 800.1|,

|31087649|gb|AAM93797.1|,

|31087638|gb|AAM93792.11,

|31087632|gb|AAM93789.1|,

|31087626|gb|AAM93868.1|,

|31087615|gb|AAM93863.1|,

|31087609|gb|AAM93 860.11,

|31087486|gb|AAM93 834.11,

|31087480|gb|AAM93831.1|,

|31087474|gb|AAM93828.1|,

|31087465|gb|AAM93824.1|,31087463|gb|AAM93823.1|,31087456|gb|AAM93820.1|,31087447|gb|AAM93 817.1 j,31087435 |gb|AAM93803.1 j,31087726|gb|AAM93904.1 j,31087720|gb| AAM93901.1 j,31087714|gb|AAM93898.1|,31087708|gb| AAM93 895.11,31087702|gb| AAM93892.1 j,31087696|gb|AAM93889.11,31087690|gb|AAM93886.1 j,31087683|gb|AAM93883.1|,31087677|gb|AAM93880.1|,31087671 |gb|AAM93877.1|,31087665 |gb| AAM93874.11,31087659|gb|AAM93871.1|,31087603|gb|AAM93771.1|,31087596JgbjAAM93768.ll,31Ü8759Ü jgbjÀAM93765.1 j,31087584|gb|AAM93762.1|,31087578|gb|AAM93759.11,31087537|gb|AAM93 859.11,31087531 jgb|AAM93856.1|,31087525|gb|AAM93853.1|,31087519|gb|AAM93850.1|,31087512|gb| AAM93 847.1j,31087506jgb|AAM93844.11,31087500|gb]AAM93841.1|,31087494|gb|AAM93838.1|,31087428lgb|AAM93813.1|531087422|gb|AAM93 810.131087416|gb|AAM93807.1|,30351030|gb|AAP22705.1|,30351024|gb|AAP22702.11,30351018|gb|AAJP22699.11,303 51012|gb|AAP22696.11,30351006|gb|AAP22693.11330351000|gb|AAP22690.11,30350994|gb|AAP22687.1|,30350988jgblAAP22684.il,30350982|gb|AAP22681.1 j,30350976|gb|AAP22678.1|,30350970|gb|AAP22675.1|,30350964|gb|AAP22672.1|,30350958|gb|AAP22669.1|,30350952|gb|AAP22666.11,30350946|gb|AAP22663.1|,30350940|gb|AAP22660.1|,

31087460|gb|AAM93822.11,31087451 jgbj AAM93819.1 j,31087441|gb|AAM93806.1|,31087433|gb|AAM93802.1|,31087724|gb| AAM93903.11,31087718jgbjAAM93900.il,31087712jgbÍAAM93897.lj,31087706|gb|AAM93894.1|,31087700|gbjAAM93891.1|,31087694|gbjAAM93888.1|,31087687|gbjAAM93885.lj,3108768ljgb|AAM93882.lj,31087675jgb|AAM93879.lj,31087669jgb|AAM93876.11,31087663 jgb|AAM93873.11,31087607jgbjAAM93773.il,3108760 l|gb| AAM93770.il,31087594|gb| AAM93767.1 j,31087588jgbj ÀAM93764.1 j,31087582|gb|AAM93761.1 j,31087576|gbjAAM93758.1|,31087535|gb|AAM93858.1|,31087529|gb|AAM93855.1|,31087523 |gb|AAM93852.1 j,31087517|gb|AAM93849.1|,31087510|gb| AAM93 846.1 j,31087504|gb| AAM93 843.1 j,31087498|gb]AAM93840.1|,31087492|gb|AAM93837.1|,31087426|gbj AAM93 812.1 j,31087420|gb|AAM93 809.11,|31087409|gb|AAM93815.1|,|30351028|gb|AAP22704.1|,|30351022|gb|AAP22701.11,|303 51016|gb| AAP22698.1 j,|30351010|gb|AAP22695.1|,1303 51004|gb | AAP22692.11,|30350998|gb|AAP22689.1|,|30350992|gb| AAP22686.11,|30350986|gbjAAP22683.1 j,|30350980|gb|AAP22680.1|,|30350974|gb|AAP22677.1|,|30350968|gb|AAP22674.1|,|30350962|gb| AAP22671.1 j,|30350956|gb|AAP22668.1|,|30350950|gb|AAP22665.1 j,|30350944|gb|AAP22662.11,|30350938|gb|AAP22659.1|,

|31087458|gb|AAM93821.1|31087449|gb|AAM93818.1|31087437|gb|AAM93804.1|31087728|gb|AAM93905.1|31087722|gb|AAM93902.1|31087716|gb|AAM93899.1|31087710|gb|AAM93 896.1|31087704|gb| AAM93 893.1|31087698|gb|AAM93890.1|31087692|gb|AAM93887.1|31087685|gb|AAM93884.1|31087679|gb|AAM93 881.1|31087673|gb|AAM93878.1]31087667|gb|AAM93875.1]31087661jgb|AAM93872.1|31087605|gbjAAM93772.1|31087599|gb|AAM93769.1|31087592|gb|AAM93766.1

Ι'"» ι AmrnCl —l-1 A A Λ ίΠΤΊ^Ο 1

|31087580|gb|AAM93 760.1|31087574|gb|AAM93757.1|31087533|gb|AAM93857.1|31087527|gb|AAM93854.1|31087521 jgb jAAM93 851.1|31087514|gb|AAM93 848.1|31087508jgb|AAM93845.1|31087502|gb|AAM93842.1|31087496|gb|AAM93839.1|31087430|gb|AAM93814.1|31087424|gb|AAM93 811.1|31087418|gb|AAM93808.1(30351032|gb|AAP22706.1|30351026|gb|AAP22703.1|30351020|gb|AAP22700.1|30351014|gb|AAP22697.1|303 51008[gb|AAP22694.1|30351002|gb|AAP22691.1|30350996|gb|AAP22688.1|30350990jgb|AAP22685.1|30350984|gbjAAP22682.1|30350978|gb|AAP22679.1|30350972|gb|AAP22676.1|303 50966|gb|AAP22673.1|30350960|gb|AAP22670.1|30350954|gb|AAP22667.1|30350948|gb|AAP22664.1|30350942|gb|AAP22661.1|30350936]gb|AAP22658.1|30350934|gb|AAP22657.11,|30350928|gb|AAP22654.1|,|26245457|gb|AAN77387.1|,|27885100|gb|AAF97041.2|,|9664256|gb|AAF97043.11,

|30350932|gb|AAP22656.1|,|26245477|gb|AAN77405.1|,|1478065|gb|AAB51144.1|,|22141040|gb| AAF97037.2|,|9664254|gb|AAF97042.11,

|9664246Ígb|AAF9703 8.1 j muíante,|9664240|gb|AAF97035.1|mntante, |23954674|gb|AAN40128.1|,

|23954670|gb|AAN40126.1|,|23954664|gb| AAN40123.1 j,|23954658|gb|AAN40120.1|,|23954652|gb|AAN40117.1|,|23954646|gb|AAN40114.1|,|23954638|gb|AAN40110.1|,|23954632|gb|AAN40107.1|,|23954626|gb| AAN40104.1 j,|23954618|gb|AAN40100.11,|23954612|gb|AAN40097.1|,|23954606|gb|AAN40094.1|,|23954600|gb|AAN40091.11,|23954594|gb|AAN40088.1|,|23954588|gb|AAN40085.1|,|23954582|gb| AAN40082.1|,|6690780|gb|AAF24339.1|AF197341_6,|6690767|gb|AAF24326.1|AF197339_5,

|23954668|gb|AAN40125.1|,|23954662|gb|AAN40122.1|,|23954656|gb|AAN40119.1|,|23954650|gb|AAN40116.1|,|23954642|gb|AAN40112.1|,|23954636|gb|AAN40109.1|,|23954630|gb|AAN40106.1|,|23954622|gb|AAN40102.1|,|23954616|gb|AAN40099.1|,|23954610|gb|AAN40096.1|,|23954604|gb| AAN40093.11,j23954598jgbjAAN40090.1j,|23954592|gb| AAN40087.11,|23954586|gb|AAN40084.1|,

|17981627|gb|AAL51097.1|,

|1495975|gb|AAB06255.1|,

11495966|gb|AAB06249.11,

|1495957|gb|AAB06243.1|,

|1263019|gb|AAB05098.1|,

|56200052|gb|AAM10883.2|,

|27885082|gb|AAM10877.2|,

|24967273|gb|AAM10856.2|,

|22858658|gb|AAN05829.1|,

|22858652jgb|AAN05826.1|,

|22858646|gb|AAN05823.1|,

|22858640|gb|AAN05 820.11,

|22858633|gb|AAN05817.1|,

|22858626|gb|AAN05814.1|,

|22858620jgb|AAN05811.1|,

|22858613 |gb|AAN05 808.1|,

|22858607|gb|AAN05805.1|,

|22858601|gb|AAN05802.1|,

|22858595|gb|AAN05799.1|,

|22858589|gb|AAN05796.1|,

|22143038|gb|AAM10917.2|,

|20126986|gb|AAM10928.1|,

|20126980|gb|AAM10925.1|,

|20126973|gb|AAM10922.1|,

|1495983|gb|AAB06260.1|,|1495972|gb|AAB06253.1|,|1495963|gb|AAB06247.1|,ll495954jgblAAB06241.il,|328657|gb|AAA80325.11,|30410842|gb|AAM10902.2|,|27885080|gb|AAM10853.2|,|2285 8662|gb| AAN05 831.11,|22858656|gb|AAN05828.1|,|22858650|gb|AAN05825.1|,|2285 8644|gb| AAN05 822.11,|22858638|gb|AAN05819.1|,|22858630|gb|AAN05816.1|,|22858624|gb|AAN05813.1|,|22858618|gb|AAN05810.1|,|22858611|gb|AAN05807.1|,|22858605|gb|AAN05804.1|,|22858599|gb|AAN05801.1|,|22858593 |gb|AAN05798.1|,|22858587|gb|AAN05795.1|,|20142335|gb|AAM10842.2|,|20126984|gb|AAM10927.1|,|20126978|gb|AAM10924.1|,|20126970|gb|AAM10921.1|,

|30350930|gb|AAP22655.1|,|26245467|gb|AAN77396.11,|27885102|gb|AAF97045.4|,|9664258|gb|AAF97044.1|,|9664250|gb|AAF97040.11,|9664242|gb| AAF97036.11,|23954672|gb | AAN40127.11,|23954666|gb|AAN40124.1|,|23954660|gb|AAN40121.1|,|23954654|gb|AAN40118.1|,|23954648|gb|AAN40115.1|,|23954640|gb|AAN40111.1|,|23954634|gb|AAN40108.1|,|23954628|gb|AAN40105.1|,|23954620|gb|AAN40101.1|,|23954614|gb|AAN40098.1|,|23954608|gb|AAN40095.11,|23954602|gb|AAN40092.1|,nooc/t^OAIrrW Δ ATsJADDSQ.I L

— —. · ------- I,

|23954590|gb|AAN40086.1|,|239545 84|gb|AAN40083.11,|23954580|gb|AAN40081.11,|6690774|gb|AAF24333.1 |AF197340_7,|6690760|gb| AAF24319.1 |AF19733 8_7

|1495978|gb|AAB06257.1|,|1495969|gb|AAB06251.1|,|1495960|gb|AAB06245.1|,|1469314|gb|AAB05050.1|,|469246|gb |AAA44865.11,|29029458|gb|AAM10899.2|,|27777706|gb|AAM10913.2|,|22858660|gb|AAN05830.1|,|22858654|gb|AAN05827.1|,|22858648|gb|AAN05824.1|,|2285 8642|gb|AAN05821.11,|22858636|gb|AAN05818.1|,|22858628|gb|AAN05815.1|,|22858622|gb|AAN05812.1|,|22858615|gb|AAN05809.1|,|2285 8609|gb|AAN05806.1|,|22858603|gb|AAN05803.1|,|22858597|gb|AAN05800.1|,|22858591|gb|AAN05797.1|,l22858585lgblAAN05794.ll,|201269S>8|gb]AAM10929.1|,|20126982|gb|AAM10926.1|,|20126975|gb|AAM10923.1|,|20126968|gb|AAM10920.1|,20126965|gb|AAM10919.1

20126957|gb|AAM10915.1

20126947|gb|AAM10911.1

20126941 |gb|AAMl 0908.1

20126935|gb|AAM10905.1

20126927jgbj AAMl 0901.1

20126919|gb|AAM10897.1

20126913|gb|AAM10894.1

20126905|gb|AAM10890.1

20126897|gb|AAM10886.1

20126889|gb|AAM10882.1

20126883jgb|AAM10879.1

20126873|gb|AAM10874.1

20126867|gb|AAMl 0871.1

20126861|gb|AAM10868.1

20126855|gb|AAM10865.1

20126849|gb|AAM10862.1

20126843|gb|AAM10859.1

20126835|gb|AAM10855.1

20126826|gb| AAMl 0851.1

20126820jgbj AAM10848.1

20126814|gb|AAM10845.1

20126806|gb|AAM10841.1

20126800jgb|AAM10838.1

16118391|gb|AAL12755.1|,

16118357|gb|AAL12725.1|,

16118318|gb| AAL12692.1 j,

16118288|gb|AAL12665.1|,

16118258jgbjAAL12638.il,

45360197jgb|AAS59230.1|,

45360166|gb|AAS59202.1|,82319636jsp|Q9QBZ7|Q9QBZ7_9HIVl582319634|sp)Q9QBY9|Q9QBY9_9HIVl,82319632|sp|Q9QBYl |Q9QBY1_9HIV1,82314771 jspÍQ90VS7|Q90VS7_9HIVl,82313 829jsp jQ8UT04|Q8UT04_9HIVl,82309245jspjp90297|P90297_9HIVl582308943|sp|041884|041884_9HIVl582308857jspjo09527Í009527_9fflVls82307713|sp|Q9WLX9|Q9WLX9_9HIV 1,82307711 |sp|Q9WLX7(Q9WLX7_9HIVl,82307709jspÍQ9WLX5ÍQ9WLX5_9HIVl,82307707|spÍQ9WLX3|Q9WLX3_9HrV 1,82307705|sp|Q9WLXl|Q9WLXl_9HIVl,82307703jspjQ9WLW9|Q9WLW9_9HIVl,82307691|sp|Q9WLL6|Q9WLL6_9fflVl,82307127|sp|Q9W7X3 |Q9W7X3_9HIV1,82307125Ísp|Q9W7Xl|Q9W7Xl_9HIVl,

|20126963|gb| AAM 10918.1

|20126954|gb| AAMl 0914.1

|20126945|gb|AAM10910.1

|20126939]gb|AAM10907.1

|20126933jgb|AAMl0904.1

|20126925jgb| AAMl 0900.1

|20126917ÍgbjAAM10896.1

|20126909Ígb|AAMl 0892.1

|20126903jgb|AAM10889.1

j20126895|gbjAAM10885.1

|20126887|gb|AAM10881.1

|20126881|gb|AAMl 0878.1

j2012687ljgb|AAM10873.1

|20126865jgbj AAMl 0870.1

|20126859|gb|AAM10867.1

|20126853|gb|AAM10864.1

|20126847|gb|AAM10861.1

Í20126841|gbjAAM10858.1

Í20126833jgbjAAM10854.1

j20126824jgbjAAM10850.1

Í20126818|gbjAAM10847.1

Í20126812|gb|AAM10844.1

Í20126804jgbjAAM10840.1

|20126798|gb|AAM10837.1

|1611838ljgbÍAAL12746.1

jl6118347jgbjAAL12716.1

|16118308jgb|AAL12683.1

116118278 jgbj AALl2656.1

|45360217|gb| AAS59248.1

|45360186|gb|AAS59220.1

|45360156|gbjAAS59193.1

|20126959|gb|AAM10916.1j20126949jgbjAAM10912.1Í20126943jgbjAAM10909.1j20126937jgbjAAMl0906.1Í2012693ljgb|AAM10903.1j2012692ljgbjAAM10898.1j20126915|gbÍAAM10895.1|20126907|gb|AAM10891.1j20126899jgbjAAM10887.1j20126893jgbjAAM10884.1j20126885jgb|AAM10880.1Í20126875jgbjAAM10875.1|20126869|gb|AAM10872.1|20126863|gb|AAM10869.1|20126857|gb|AAM10866.1|20126851|gb|AAM10863.1|20126845jgbj AAMl 0860.1Í20126839jgbjAAM10857.1j20126828jgbiÁÁMl 0852.1\20126822)gbj AAMl0849.1Í20126816jgbÍAAM10846.1(20126810|gb|AAM10843.1j20126802jgb|AAM10839.1|16118401|gb|AAL12764.1jl6118371 jgbjAAL12737.1jl6118335jgbjAAL12706.1|16118298|gb|AAL12674.1jl6118268jgbjAAL12647.1|45360207|gb|AAS59239.1|45360176|gb|AAS59211.1j45360146|gb|AAS59184.1|82319635|sp|Q9QBZ3|Q9QBZ3_9HIVl|82319633|sp|Q9QBY5|Q9QBY5_9HIVl|82319066|sp|Q9IBN2|Q9IBN2_9HIVlÍ82313851 jspÍQ8UTJ8|Q8UTJ8_9HIVl|82309401 |sp|Q5DID4]Q5DID4_9HIVl|82309222|sp|P88432|P88432_9HIVl|82308858[sp|009529|009529_9HIVl|82308265|sp|Q9YPG6|Q9YPG6_9HIVl|82307712|sp|Q9WLX8|Q9WLX8_9HIVl|82307710|sp|Q9\VLX6ÍQ9\VLX6_9HIVl|82307708|sp|Q9WLX4|Q9WLX4_9HIVl|82307706|sp|Q9WLX2|Q9WLX2_9HTVl|82307704jsp|Q9WLX0|Q9WLX0_9HIVl|82307692|sp|Q9WLL7|Q9WLL7_9HIVlj823 07223 jsp|Q9 WA3 5 jQ9 WA3 5_9HIV 1|823 07126|sp |Q9 W7X2 |Q9 W7X2_9HIV 1Í82307124jspÍQ9W7X0jQ9W7X0_9HIVl82307121|sp|Q9W7U0|Q9W7U0_9fflVl,

82306571|sp|Q9QNZ7|Q9QNZ7_9HIVl,

82306240|sp|Q9QGW0|Q9QGW0_9fflVl,

82306238|sp|Q9QGV8|Q9QGV8_9HIVl,

82306236|sp|Q9QGV6|Q9QGV6_9HIVl,

82306234|sp|Q9QGV4|Q9QGV4_9HIVl,

82306232)sp|Q9QGV2|Q9QGV2_9HIVl,

82306230|sp|Q9QGV0|Q9QGV0_9HIVl,

82306228|sp|Q9QGU8|Q9QGU8_9HIVl,

82306226|sp|Q9QGU6|Q9QGU6_9HIVl,

82306224|sp|Q9QGU4]Q9QGU4_9HIVl,

82306222|sp|Q9QGU2|Q9QGU2_9HIVl,

82306220|sp|Q9QGU0|Q9QGU0_9HIVl,

82306218|sp|Q9QGT8|Q9QGT8_9HrVl,

82306216]sp|Q9QGT6|Q9QGT6_9HIVl,

82305874|sp|Q9Q6H7|Q9Q6H7_9HIVl,

82305872|sp|Q9Q6G4|Q9Q6G4_9HIVl,

82305415jsp|Q9JE92jQ9JE92_9HIVl,

82305413jspjQ9JE90iQ9JE90_9HTvl,

8230541 l|sp|Q9JE88|Q9JE88_9HIVlJ

82305409|sp|Q9JE86|Q9IE86_9HIVl,

82305046|sp|Q9IR17|Q9IR17_9HrVl,

82305044|sp)Q9IR15|Q9IR15_9HrVl,

82305042|sp|Q9IR13|Q9IR13_9HIVl,

82305040|sp|Q9IRll|Q9IRll_9HIVl,

82305038|sp|Q9IR09|Q9IR09_9mVl,

82305036|sp|Q9IR07|Q9IR07_9HIVl,

82305034|sp|Q9IR05 |Q9IR05_9HIV 1,

82305032|sp|Q9IR03|Q9IR03_9HIVl3

82305030|sp|Q9IR01|Q9IR01_9HIVl3

82305028]sp|Q9IQZ9|Q9IQZ9_9HIVl,

82305026|sp|Q9IQZ7|Q9IQZ7_9HIVl,

82305024[sp |Q9IQZ5 |Q9IQZ5_9HIV 1,

82305022|sp j Q9IQZ3 |Q9IQZ3_9HIV 1,

82305020|sp|Q9IQZl|Q9IQZl_9HrVl,

82305018|sp I Q9IQY9|Q9IQY9_9HTV 1,

82305016|sp|Q9IQY7|Q9IQY7_9HIV 1,

82305014|sp|Q9IQY5|Q9IQY5_9HIVl,

82305012|sp|Q9IQY3|Q9IQY3_9HIVl,

82305010|sp|Q9IQYl|Q9IQYl_9HIVl,

82305008|sp|Q9IQX9|Q9IQX9_9HIVl,

82305006|sp|Q9IQX7|Q9IQX7_9fflVl,

82305004|sp|Q9IQX51 Q9IQX5_9HIV 1,

82305002|sp|Q9IQX3|Q9IQX3_9HIVl,

82305000|sp|Q9IQXl|Q9IQXl_9HIVl,

82304998|sp|Q9IQW9|Q9IQW9_9HIVl,

82303504|sp|Q9DQV2|Q9DQV2_9HIVl,

82303502|sp|Q9DQV0|Q9DQV0_9HIVl,

|82306895|sp|Q9QRB0|Q9QRB0_9HIVl|82306241 |sp|Q9QGWl|Q9QGWl_9HIVl|82306239|sp|Q9QGV9|Q9QGV9_9HTVl|82306237|sp|Q9QGV7|Q9QGV7_9HrVl|82306235|sp|Q9QGV5|Q9QGV5_9HrVl|82306233|sp|Q9QGV3|Q9QGV3_9HrVl18230623 l|sp|Q9QGVl |Q9QGV1_9HIV1|82306229|sp|Q9QGU9|Q9QGU9_9HTVl|82306227|sp|Q9QGU7|Q9QGU7_9HrVlj82306225|sp|Q9QGU5 |Q9QGU5_9HTV 1|82306223|sp|Q9QGU3|Q9QGU3_9fflVl|82306221 |sp|Q9QGUl|Q9QGUl_9HTVl|82306219|sp|Q9QGT9|Q9QGT9_9fflVl|82306217|sp|Q9QGT7|Q9QGT7_9HIVl|82305876|sp|Q9Q6D|Q9Q6D_9HTVl|82305873|sp|Q9Q6H0|Q9Q6H0_9HIVl|82305416|sp|Q9JE93|Q9JE93_9fflVl|82305414|sp|Q9JE91|Q9JE91_9HIVlj823054i2ispiQ9JE83jQ9jE89_9KTv 1|82305410|sp|Q9 JE87|Q9 JE87_9HIV 1|82305047|sp|Q9IR18|Q9IR18_9fflVl|82305045|sp|Q9IR16|Q9IR16_9fflVl)82305043|sp|Q9IR14|Q9IR14_9HIVl|82305041 |sp|Q9IR12|Q9IR12_9HIVl|82305039|sp|Q9IR10|Q9IR10_9HIVl|82305037|sp|Q9IR08|Q9IR08_9HrVl)82305035|sp|Q9IR06|Q9IR06_9HIVl|82305033|sp|Q9IR04|Q9IR04_9HIVl[8230503 l|sp|Q9IR02|Q9IR02_9HIVl|82305O29|sp|Q9IR00|Q9IR00_9HIVl|82305027|spjQ9IQZ8|Q9IQZ8_9HTVl|82305025|sp|Q9IQZ6|Q9IQZ6_9HTVl|82305023|sp|Q9IQZ4|Q9IQZ4_9HTVl|82305021|sp|Q9IQZ2|Q9IQZ2_9HrVl|82305019|sp |Q9IQZ0|Q9IQZ0_9HIV 1]82305017|sp|Q9IQY8|Q9IQY8_9HIVl|82305015|sp|Q9IQY6|Q9IQY6_9HIVl|82305013|sp|Q9IQY4|Q9IQY4_9HIVl|8230501 l]sp|Q9IQY2|Q9IQY2_9HIVl|82305009|sp|Q9IQY0|Q9IQY0_9HIVl|82305007|sp|Q9IQX8|Q9IQX8_9HrVl|82305005|sp|Q9IQX6|Q9IQX6_9HIVl|82305003|sp|Q9IQX4|Q9IQX4_9HIVl|82305001 |sp|Q9IQX2|Q9IQX2_9HIVl182304999|sp |Q9IQX0 |Q9IQX0_9HIV1|82304669|sp|Q9ICH2|Q9ICH2_9HIVl|82303503|sp|Q9DQVl|Q9DQVl_9HIVl182303501 |sp|Q9DQU9|Q9DQU9_9HIVl182303500|sp |Q9DQU81Q9DQU89HIV1,

182303498jsp |Q9DQU61 Q9DQU6_9HIV 1,

|82303496|sp|Q9DQU4|Q9DQU4_9HIVl,

|82303494|sp|Q9DQU2|Q9DQU2_9HIVl,

|82303492|sp|Q9DQU0|Q9DQU0_9HIVl,

|82303490|sp|Q9DQT8|Q9DQT8_9HIVl,

182303488jsp |Q9D QT6 |Q9DQT6_9HIV 1,

|82303486|sp|Q9DQT4|Q9DQT4_9HIVl,

|82303484|sp|Q9DQT2|Q9DQT2_9HIVl,

|82303482|sp|Q9DQT0|Q9DQT0_9HIVl,

|82303480|sp|Q9DQS8|Q9DQS8_9HIVl,

|82303478|sp|Q9DQS6|Q9DQS6_9HIVl)

|82303476|sp|Q9DQS4|Q9DQS4_9fflVl,

|82303474|sp|Q9DQS2|Q9DQS2_9HIVl,

j82303472|sp|Q9DQS0|Q9DQS0_9HIVl,

|82303470|sp|Q9DQR8|Q9DQR8_9HIVl,

|82303468|sp|Q9DQR6|Q9DQR6_9HIVl,

|82303466|sp|Q9DQR4|Q9DQR4_9HIVl,

ΙΟΟΙΛ-ϊ/Κ/ΙΙο^Ι/^ΟΤΛΟϋΟΙΟΟΤΛΓΜΪΟ ΟΧΤΤΛ/1

|82303462|sp|Q9DQR0|Q9DQR0_9HTVl,

|82303460|sp|Q9DQQ8|Q9DQQ8_9tnVl,

|82303458|sp|Q9DQQ6|Q9DQQ6_9HIVl,

|82303456|sp|Q9DQQ4|Q9DQQ4_9HIVl,

|82303454|sp|Q9DQQ2|Q9DQQ2_9HIVl,

|82303452|sp|Q9DQQ0|Q9DQQ0_9HIVl,

|82303450|sp|Q9DQP8|Q9DQP8_9HIVl,

|82303448|sp|Q9DQP6|Q9DQP6_9HIVl,

|82303446|sp|Q9DQP4|Q9DQP4_9HIVl,

|82303444|sp|Q9DQP2|Q9DQP2_9HIVl,

|82303442|sp|Q9DQP0|Q9DQP0_9HIVl,

|82303440|sp|Q9DQN8|Q9DQN8_9HIVl,

|82303228|sp|Q9DKG5|Q9DKG5_9HIV 1,

|82303224|sp|Q9DKE9|Q9DKE9_9HIVl,

|82303220|sp|Q9DKD2|Q9DKD2_9HIVl,

|82302338|sp|Q994C4|Q994C4_9HIVl,

|82302334|sp|Q994A6|Q994A6_9HrVl,

|82301506|sp|Q97012|Q97012_9HIVls

|82301504|sp|Q97007|Q97007_9HIVl,

|82300512|sp|Q90DD4|Q90DD4_9HrVl,

|82299983 |sp|Q908N0|Q908N0_9HIVl,

|82299979|sp|Q908L2|Q908L2_9HIVl,

|82299975|sp|Q908J4|Q908J4_9HIVl>

|82299971|sp|Q908H6|Q908H6_9HIVl,

|82299267|sp|Q8UTS9|Q8UTS9_9HIVl,

|82299263|sp|Q8UTRl|Q8UTRl_9HIVl,

|82299259|sp|Q8UTP3|Q8UTP3_9HIVl,

182299255jsp |Q8UTM51 Q8UTM5_9HIV 1,

|8229925ljspÍQ8UTK7|Q8UTK7_9HIVl,

|82303499|sp|Q9DQU7|Q9DQU7_9HQVl|82303497|sp|Q9DQU5|Q9DQU5_9HIVl|82303495|sp|Q9DQU3|Q9DQU3_9HIVl|82303493|sp|Q9DQUl|Q9DQUl_9HIVl182303491 |sp|Q9DQT9|Q9DQT9_9HIVl|82303489|sp|Q9DQT7|Q9DQT7_9HIVl|82303487|sp|Q9DQT5|Q9DQT5_9HQYl|82303485|sp|Q9DQT3|Q9DQT3_9HIVl|82303483|sp|Q9DQTl|Q9DQTl_9HIVl|8230348 l|sp|Q9DQS9|Q9DQS9_9HIVl|82303479|sp|Q9DQS7|Q9DQS7_9HTVl|82303477|sp|Q9DQS5|Q9DQS5_9HIVl|82303475|sp|Q9DQS3|Q9DQS3_9HIVl|82303473|sp|Q9DQSl|Q9DQSl_9HIVl|82303471 |sp|Q9DQR9|Q9DQR9_9HIVl|82303469|sp|Q9DQR7|Q9DQR7_9fflVl|82303467|sp|Q9DQR5|Q9DQR5_9HIVl|82303465|sp|Q9DQR3|Q9DQR3_9HIVlig2303463lsT,ln9Dr>Rlln9Dr>P^l 9HIV1|82303461|'sp|lQ9DQQ9|Q9DQQ9~9HIVl

|82303459|sp|Q9DQQ7|Q9DQQ7_9fflVl|82303457|sp|Q9DQQ5|Q9DQQ5_9HIVl|82303455|sp|Q9DQQ3|Q9DQQ3_9HIVl|82303453|sp|Q9DQQl|Q9DQQl_9HIVl|8230345 l|sp|Q9DQP9|Q9DQP9_9HIVl|82303449|sp|Q9DQP7|Q9DQP7_9HIVl|82303447|sp|Q9DQP5|Q9DQP5_9HrVl|82303445|sp|Q9DQP3|Q9DQP3_9HIVl|82303443|sp|Q9DQPl|Q9DQPl_9HIVl|82303441 |sp|Q9DQN9|Q9DQN9_9HIVl|82303439|sp|Q9DQN7|Q9DQN7_9HIVl|82303226|sp|Q9DKF7|Q9DKF7_9HIVl|82303222|sp|Q9DKEl|Q9DKEl_9HIVl|82302500|sp|Q99BZ6|Q99BZ6_9HIVl|82302336|sp|Q994B5|Q994B5_9fflVl|82301507|sp|Q97014|Q97014_9HIVl|82301505|sp|Q97010|Q97010_9HIVl|82301503 |sp|Q97005|Q97005_9HIVl|82300079|sp|Q909R2|Q909R2_9fflVl|82299981 |sp|Q908Ml |Q908M1_9HIV1|82299977|sp|Q908K3|Q908K3_9HIVl|82299973|sp|Q908I5|Q908I5_9HTVl|82299269|sp|Q8UTT8|Q8UTT8_9HIVl|82299265|sp|Q8UTS0|Q8UTS0_9HTVl|82299261 |sp|Q8UTQ2|Q8UTQ2_9HIVl|82299257lsp|Q8UTN4|Q8UTN4_9HIVl|82299253 |sp|Q8UTL6|Q8UTL6_9HIVl|82299248|sp|Q8UTI9|Q8UTI9_9HIVl82299246|sp|Q8UTI0|Q8UTI0_9HIVl,

82299242|sp|Q8UTG2|Q8UTG2_9ffiVl,

82299237|sp|Q8UTE4|Q8UTE4_9HIVl,

82299233 jsp |Q8UTC6|Q8UTC6_9HIV 1,

82299229|sp|Q8UTA8|Q8UTA8_9HIVl,

82299224|sp|Q8UT90|Q8UT90_9HIVl,

82299220|sp|Q8UT72|Q8UT72_9KQYl,

82299216|sp|Q8UT54]Q8UT54_9HIVl,

82299212|sp|Q8UT36|Q8UT36_9HIVl,

82299208|sp|Q8UT18|Q8UT18_9HIVl,

82299204|sp|Q8USZ5|Q8USZ5_9HIVl,

82299200|sp|Q8USX7|Q8USX7_9HIVl,

82299196|sp|Q8USV9ÍQ8USV9_9HrVl,

82299192|sp|Q8USUl|Q8USUl_9HIVl,

82299188|sp|Q8USS3|Q8USS3_9HIVl,

82295688|sp|Q8AFF2|Q8AFF2_9HIVl,

82295684|sp|Q8AFD4|Q8AFD4_9HIVl,

82292064|sp|Q7SP79|Q7SP79_9HTVl,

82292üó2jspjQ7SF77jQ7SF77_9HiV 1,

82292060|sp|Q7SP75|Q7SP75_9HIVl,

82292058|sp|Q7SP73|Q7SP73_9HIVl,

82292056|sp|Q7SP71|Q7SP71_9HIVl,

82292054|sp|Q7SP69|Q7SP69_9HIVl,

82292052|sp|Q7SP67|Q7SP67_9HIVl,

82292050|sp|Q7SP65|Q7SP65_9HIVl,

82292048[sp|Q7SP63|Q7SP63_9HIVl,

82292046|sp|Q7SP61|Q7SP61_9HIVl,

82292044|sp|Q7SP59|Q7SP59_9HIVl,

82292042|sp|Q7SP57|Q7SP57_9HrVl,

82292040|sp)Q7SP55|Q7SP55_9HIVl,

82292038|sp|Q7SP53|Q7SP53_9HIVl,

82292036|sp|Q7SP51 |Q7SP51_9HIV1,

82292034|sp|Q7SP49|Q7SP49_9HrVl,

82292032|sp|Q7SP47|Q7SP47_9HIVl,

82292030|sp|Q7SP45|Q7SP45_9HIVl,

82292028|sp|Q7SP43|Q7SP43_9HIVl,

82292026|sp|Q7SP41 |Q7SP41_9HIV1,

82292024|sp|Q7SP39|Q7SP39_9HIVl,

82292022|sp|Q7SP37|Q7SP37_9HIVl,

82292020|sp|Q7SP35|Q7SP35_9HIVl,

82292018|sp|Q7SP33|Q7SP33_9HIVl5

82292016|sp|Q7SP31 |Q7SP31_9HIV15

82292014|sp|Q7SP29]Q7SP29_9HIVl,

82292012|sp|Q7SP27|Q7SP27_9HIVl,

82292010|sp|Q7SP25 |Q7SP25_9E0TV1,

82292008|sp|Q7SP23|Q7SP23_9HIVl,

82292006|sp|Q7SP21|Q7SP21_9HIVl,

82292004|sp|Q7SP19|Q7SP19_9HIVl)

|82299244|sp|Q8UTHl|Q8UTHl_9HIVl|82299240|sp|Q8UTF3|Q8UTF3_9HIVl|82299235|sp|Q8UTD5|Q8UTD5_9HIVl|82299231 |sp|Q8UTB7|Q8UTB7_9HIVl|82299227|sp|Q8UT99|Q8UT99_9HIVl|82299222|sp|Q8UT81 |Q8UT81_9HIV1|82299218|sp|Q8UT63|Q8UT63_9HIVl|82299214|sp|Q8UT45|Q8UT45_9HIVl(82299210|sp|Q8UT27|Q8UT27_9fflVl|82299206|sp|Q8UT09|Q8UT09_9HIVl|82299202|sp|Q8USY6|Q8USY6_9HIVl|82299198|sp|Q8USW8|Q8USW8_9HIVl|82299194|sp|Q8USV0|Q8USV0_9HIVl|82299190|sp|Q8UST2|Q8UST2_9HIVl|82299014|sp|Q8UNF4|Q8UNF4_9fflVl|82295686|sp|Q8AFE3]Q8AFE3_9HTVl|82293903|sp|Q80162|Q80162_9fflVl|82292063|sp|Q7SP78|Q7SP78_9HIVl

lonuniníil__ií-v'70'D'7/:l/~\'70t>r7< ΟΈΓΤΛΤΊ

/ οχ /υ|ν,//οχ / Ι Λ

|82292059|sp|Q7SP74|Q7SP74_9HrVl|82292057|sp|Q7SP72|Q7SP72_9HIVl|82292055|sp|Q7SP70|Q7SP70_9HIVl|82292053|sp|Q7SP68|Q7SP68_9HIVl18229205 l|sp|Q7SP66|Q7SP66_9HIVl|82292049|sp|Q7SP64]Q7SP64_9HIVl|82292047|sp|Q7SP62|Q7SP62_9HrVl182292045jsp |Q7SP60|Q7SP60_9HIV 1|82292043|sp|Q7SP58|Q7SP58_9HIVl|82292041 |splQ7SP56|Q7SP56_9HIVl|82292039|sp|Q7SP54|Q7SP54_9HIVl|82292037|sp|Q7SP52|Q7SP52_9HIVl|82292035|sp|Q7SP50|Q7SP50_9HIVl[82292033 jsp |Q7 SP48 |Q7SP48_9HTV 1182292031|sp |Q7SP46 |Q7SP46_9HIV1|82292029|sp|Q7SP44|Q7SP44_9HrVl|82292027|sp|Q7SP42|Q7SP42_9HrVl|82292025|sp|Q7SP40|Q7SP40_9HTVl|82292023|sp|Q7SP3 8 |Q7SP3 8_9HIV 1|82292021 |sp|Q7SP36|Q7SP36_9HIVl|82292019|sp|Q7SP34|Q7SP34_9HIVl|82292017|sp|Q7SP32|Q7SP32_9HIVl|82292015|sp|Q7SP30|Q7SP30_9HIVl|82292013|sp|Q7SP28|Q7SP28_9HIVl|8229201 l|sp|Q7SP26|Q7SP26_9HIVl|82292009|sp|Q7SP24|Q7SP24_9HIVl|82292007|sp|Q7SP22|Q7SP22_9HIVl|82292005|sp|Q7SP20|Q7SP20_9HIVlj82292003 jsp |Q7SP 18 |Q7SP 1 8_9HIV 182292002|sp|Q7SP17|Q7SP17_9HTVl,

82292000 jsp|Q7SP 15 |Q7SP 15_9HIV 1,

82291998|sp|Q7SP 13 |Q7SP 13_9HTV 1,

82291996|sp|Q7SP 11 |Q7SP 11_9HTV 1,

82291994|sp|Q7SP09|Q7SP09_9fflVl,

82291992|sp|Q7SP07|Q7SP07_9HIVl,

82291990|sp|Q7SP05 |Q7SP05_9HIV1,

82291988|sp|Q7SP03 |Q7SP03_9HIV 1,

82291986|sp|Q7SP01|Q7SP01_9HIVl,

82291984|sp|Q7SNZ9|Q7SNZ9_9HrVl,

82291982|sp|Q7SNZ7|Q7SNZ7_9HIVl,

82291980|sp|Q7SNZ5|Q7SNZ5_9fflVl,

82291978|sp|Q7SNZ3|Q7SNZ3_9HrVl,

82291976|sp|Q7SNZl|Q7SNZl_9HIVl,

82291974|sp|Q7SNY9|Q7SNY9_9fflVl,

82291972|sp|Q7SNY7|Q7SNY7_9HIVl,

82291970|sp|Q7SNY5|Q7SNY5_9HIVls

82291968|sp|Q7SNY3 |Q7SNY3_9HIV1,

82291966|sp|Q7SNYl|Q7SNYl_9HIVl,

82291964|sp|Q7SNX9|Q7SNX9_9mVl,

82291962|sp|Q7SNX7|Q7SNX7_9HIVl,

82291960|sp|Q7SNX5|Q7SNX5_9HIVl,

82291958|sp|Q7SNX3|Q7SNX3_9HIVl5

82291956|sp|Q7SNXl|Q7SNXl_9HIVl,

82291954|sp|Q7SNW9|Q7SNW9_9HIVl,

82291952|sp|Q7SNW7|Q7SNW7_9HIVl,

82291950|sp]Q7SNW5|Q7SNW5_9HIVl,

82291948|sp|Q7SNW3 |Q7SNW3_9HIV1,

82291946|sp|Q7SNWl |Q7SNW1_9HIV1,

82291408|sp|Q7SIK3 |Q7SIK3_9HIV1,

82291406|sp|Q7SU7|Q7SU7_9HIVl,

82291404|sp|Q7SU4|Q7Sn4_9HIVl,

82291400|sp|Q7SII5(Q7SII5_9HIVl,

82291398|sp|Q7Sffl9|Q7S3H9_9HIVl5

82291330|sp]Q79786|Q79786_9HIVl,

82290630|sp|Q77YS9|Q77YS9_9HIVl,

82289768|sp|Q76351|Q76351_9HIVl,

82289766|sp|Q76349|Q76349_9HIVl,

82289618|sp)Q75640|Q75640_9HIVl,

82289616|sp|Q75638|Q75638_9HIVl,

82289614|sp|Q75635|Q75635_9HIVl,

82289612|sp|Q75633|Q75633_9fflVl,

82289610|sp|Q75631]Q75631_9HIVl,

82289608|sp|Q75629|Q75629_9HIVl,

82289606|sp|Q75627|Q75627_9HrVl,

82289604|sp)Q75625|Q75625_9HIVl,

82289602|sp]Q75623|Q75623_9HIVl,

82289600|sp|Q75621|Q75621_9HIVl,

|82292001 |sp|Q7SP 16|Q7SP16_9HIV1|82291999|sp|Q7SP14|Q7SP14_9HIVl|82291997|sp|Q7SP 12|Q7SP 12_9HTV1|82291995|sp|Q7SP 10|Q7SP 10_9HTV1|82291993 jsp|Q7SP08|Q7SP08_9HIVl|82291991|sp|Q7SP06|Q7SP06_9HrVl|82291989|sp|Q7SP04|Q7SP04_9HIVl|82291987|sp|Q7SP02|Q7SP02_9HIVl|82291985|sp|Q7SP00|Q7SP00_9HIVl|82291983|sp|Q7SNZ8|Q7SNZ8_9HIVl|82291981|sp|Q7SNZ6|Q7SNZ6_9HIVl|82291979|sp|Q7SNZ4|Q7SNZ4_9HIVl|82291977|sp|Q7SNZ2|Q7SNZ2_9HrV 1|82291975|sp|Q7SNZ0|Q7SNZ0_9HrVl|82291973|sp|Q7SNY8|Q7SNY8_9HTVl|82291971 |sp|Q7SNY6|Q7SNY6_9HIVl|82291969|sp|Q7SNY4|Q7SNY4_9HIVl|82291967|spjQ7SNY2|Q7SNY2_9Hiyi|822919651sp IQ 7 SNYO j Q7 SNY0_9HTv í|82291963|sp|Q7SNX8|Q7SNX8_9HIVl|82291961|sp|Q7SNX6|Q7SNX6_9HIVl|82291959|sp|Q7SNX4|Q7SNX4_9fflVl]82291957|sp|Q7SNX2|Q7SNX2_9HTVl|82291955|sp|Q7SNX0|Q7SNX0_9HIVl|82291953|sp|Q7SNW8|Q7SNW8_9HIVl|82291951 |sp|Q7SNW6|Q7SNW6_9HIVl|82291949|sp|Q7SNW4|Q7SNW4_9fflVl|82291947|sp|Q7SNW2|Q7SNW2_9fflVl|82291409|sp|Q7SIK4|Q7SIK4_9HIVl|82291407|sp|Q7Sn9|Q7SÜ9_9fflVl|82291405|sp|Q7SU6]Q7SU6_9HIVl|82291402|sp|Q7Sn9|Q7SII9_9HIVl|82291399|sp|Q7Sn0|Q7Sn0_9HIVl|82291395|sp|Q7SIH4|Q7SIH4_9HIVl|82291220]sp]Q79671|Q79671_9fflVl|82289769|sp|Q76352|Q76352_9B0Vl|82289767|sp|Q76350|Q76350_9HIVl|82289765|sp|Q76348|Q76348_9HIVl|82289617|sp|Q75639]Q75639_9fflVl|82289615|sp|Q75637|Q75637_9HrVl|82289613|sp|Q75634|Q75634_9HIVl|8228961 l|sp|Q75632|Q75632_9HIVl|82289609]sp|Q75630|Q75630_9HIVl|82289607|sp|Q75628|Q75628_9HIVl|82289605|sp|Q75626|Q75626_9HIVl|82289603|sp|Q75624|Q75624_9HIVl|82289601|sp|Q75622|Q75622_9HIVl|8228955 l|sp|Q75148|Q75148_9HIVl82289550|sp|Q75147|Q75147_9HIV1,

82289548|sp|Q75145|Q75145_9HrVl,

82289546|sp|Q75143|Q75143_9HTVl,

82289544|sp|Q75141|Q75141_9HIVl,

82289542|sp|Q75139|Q75139_9HIVl,

82289540|sp|Q75137|Q75137_9HIV 1,

82289538|sp|Q75135|Q75135_9HIVl,

82289536|sp|Q75133|Q75133_9HIVl,

82289534|sp|Q75131|Q75131_9HIVl,

82289396|sp|Q74460|Q74460_9HIVl,

82288578|sp|Q71957|Q71957_9HrVl,

82288576|sp|Q71955|Q71955_9HIVl,

82288574|sp|Q71953|Q71953_9HTVl,

82288572|sp|Q71951|Q71951_9HIVl,

82288570|sp|Q71949|Q71949_9HrVl,

82288061 |sp|Q70151 |Q70151_9HTV 1,

82287862|sp|Q6X0Il|Q6X0Il_9HIVl,

82287860|sp|Q6X0H9|Q6X0H9_9HIVl,

82287858jsp i QÓX0K7 jQ6X0K7_9KTv 1,

82287856|sp|Q6X0H5|Q6X0H5_9HrVl,

82287854|sp|Q6X0H2|Q6X0H2_9fflVl,

82287852|sp|Q6X0G9|Q6X0G9_9HIVl,

82287850|sp|Q6X0G6|Q6X0G6_9HIVl,

82287848|sp|Q6X0G4|Q6X0G4_9fflVl,

82287846|sp|Q6X0G2|Q6X0G2_9HIVl,

82287844|sp|Q6X0G0|Q6X0G0_9HIVl,

82286786|sp|Q6TEBl|Q6TEBl_9HIVl,

822867 82|sp|Q6TE93 |Q6TE93_9HIV1,

82286778|sp|Q6TE75|Q6TE75_9HIVl,

82286774|sp|Q6TE57|Q6TE57_9HIVl,

82285545|sp|Q6QJ02|Q6QJ02_9HIVl,

82285543|sp|Q6QJ00|Q6QJ00_9HrVl,

82285541 |sp|Q6QIZ8|Q6QIZ8_9HIVl,

82284709|sp|Q6EK36|Q6EK36_9HTVl,

82284707|sp|Q6EJW4|Q6EJW4_9HIVl,

82284705 |sp|Q6EJT2|Q6EJT2_9HIVl,

82284674|sp|Q6E6V3|Q6E6V3_9HIVl,

82283343|sp|Q5VCV6|Q5VCV6_9HIVl,

82283339|sp|Q5VCUl|Q5VCUl_9HIVl,

8228321 l|sp|Q5S5C8|Q5S5C8_9HIVl,

82283209|sp|Q5S5B2|Q5S5B2_9HIVl,

82283207|sp|Q5S592]Q5S592_9HIVl,

82281649|sp|P90285|P90285_9HTVl,

82281647|sp|P90281 |P90281_9HIV1,

82281645|sp|P90279|P90279_9HrVl,

82281591 |sp|P89820|P89820_9HIVl3

82281274|sp|P88433|P88433_9HIVl,

82281272|sp|P88430|P88430_9HIVl,

|82289549|sp|Q75146|Q75146_9HIVl|82289547|sp|Q75144|Q75144_9HIVl|82289545|sp|Q75142|Q75142_9HTVl|82289543jsp|Q75140|Q75140_9HIV1|82289541|sp|Q75138|Q75138_9HrVl|82289539|sp|Q75136|Q75136_9HIVl|82289537)sp|Q75134|Q75134_9HrVl|82289535|sp|Q75132|Q75132_9HIVl|82289472|sp|Q74750|Q74750_9HIVl|82288892|sp|Q72745|Q72745_9HIVl|82288577|sp|Q71956|Q71956_9HIVl|82288575|sp|Q71954|Q71954_9HIVl|82288573|sp|Q71952|Q71952_9mVl|82288571 |sp|Q71950|Q71950_9HTV1|82288076|sp|Q70203|Q70203_9HIVl|82288060|sp|Q70146|Q70146_9HTVl|82287861 |sp|Q6X0I0|Q6X0I0_9HTVl|82287859|sp|Q6X0H8|Q6X0H8_9HIVl

loooonofTl — l/^rVATJ/Clr^VTYUX OTTTVI

|82287855|sp|Q6X0H4|Q6X0H4_9HIVl)82287853|sp|Q6X0Hl|Q6X0Hl_9HrVl182287851 |sp|Q6X0G7|Q6X0G7_9HIVl|82287849|sp|Q6X0G5|Q6X0G5_9HrVl|82287847|sp|Q6X0G3|Q6X0G3_9HIVl|82287845|sp|Q6X0Gl|Q6X0Gl_9HIVl|82287843|sp|Q6X0F9|Q6X0F9_9HIVl|82286784|sp|Q6TEA2|Q6TEA2_9HIVl]82286780|sp|Q6TE84]Q6TE84_9HIVl|82286776|sp|Q6TE66|Q6TE66_9HIVl|82285546|sp|Q6QJ03|Q6QJ03_9HIVl|82285544|sp|Q6QJ01|Q6QJ01_9HIVl|82285542|sp|Q6QIZ9|Q6QIZ9_9HTVl|82284710|sp|Q6EK52|Q6EK52_9HIVl|82284708|sp|Q6EJZ6|Q6EJZ6_9HTVl]82284706|sp|Q6EJU0|Q6EJU0_9HIVl|82284704|sp|Q6EJQ8|Q6EJQ8_9HIVl]82283785|sp|Q66Q69|Q66Q69_9HIVl|82283341|sp|Q5VCU8|Q5VCU8_9HIVl|82283336|sp|Q5VCS7|Q5VCS7_9HIVl|82283210|sp|Q5S5C0|Q5S5C0_9HIYl|82283208|sp|Q5S5A0|Q5S5A0_9HIVl|82281650|sp|P90286|P90286_9HIVl|82281648|sp|P90284|P90284_9HIVl|82281646|sp|P90280|P90280_9HrVl|82281592|sp|P89824|P89824_9HIVl|82281275|sp|P88435|P88435_9HIVl|82281273|sp|P88431|P88431_9HIVl|8228127 l|sp|P88429|P88429_9HIVl82281270|sp|P88428|P88428_9HIVl,82281179|sp|093014|093014_9HIVl82281177|sp|093012|093012_9mVl82281175|sp|093010|093010_9fflVl82281161 |sp|0929381092938_9HIV 182281133 |sp|092772|092772_9HIVl82280572|sp|090647|090647_9HIVl82280569|sp|090644|090644_9HIVl82280560|sp|0905311090531_9HIV182280556|sp|090526|090526_9mVl82280553|sp|090523|090523_9HIVl82280551 |sp|090521 |090521_9HIV182280544|sp|090514|090514_9HIVl82280541 |sp|0905111090511_9HIV182280539|sp|090509|090509_9HIVl82280534|sp|090504|090504_9MVl82280530|sp|090500|090500_9fflVl82280513|sp|090179|090179_9HIVl

AA ι λλΙ ΑΑΑηΙ/\ΑΛΛΛΤ ΛΤΤΤΤ TA

»zz8u45zjspjuyuuy / juyuuy ÍJIU ν ι82280478|sp|090080|090080_9HIVl82280474|sp|090063|090063_9HIVl82280472|sp|089961|089961_9HrVl82280469|sp|089938|089938_9HIVl82280427|sp|073573|073573_9HrVl82280314|sp|072652|072652_9HIVl82280312|sp|072650|072650_9HIVl82280310|sp|072648|072648_9HIVl82280308|sp|072646|072646_9HIVl82280306|sp|072644|072644_9HIVl82280304|sp|072642|072642_9fflVl82280302|sp|072639|072639_9HIVl82280300|sp|072637|072637_9HIVl82280298|sp|072635|072635_9fflVl82280296|sp|072633|072633_9HIVl82280294|sp|0726311072631_9HIV182280292|sp|072629|072629_9HIVl82280290|sp|072627|072627_9HIVl82280288|sp|072625|072625_9HrVl82280286|sp|072623|072623_9HIVl82280284|sp|072621|072621_9HIVl82279874|sp|071126|071126_9HIV182279872|sp|071124)071124_9HTV182279867|sp|071086|071086_9HIVl82279706|sp|042068|042068_9HIVl82279629|sp|040602|040602_9HIVl82279627[sp|040600|040600_9HIVl82279625|sp|040598|040598_9HIVl82279623|sp|040596|040596_9HIVl

|82281269|sp|P88427|P88427_9HTVl|82281178|sp|093013|093013_9HIVl|82281176|sp|093011|093011_9HIV1|82281174|sp|093009|093009_9HIVl|82281145|sp|092803|092803_9HIVl|82281132|sp|0927711092771_9HTV 1|82280570|sp|090645|090645_9HIVl|82280563 |sp|090534|090534_9HIVl|82280558|sp|090528|090528_9HrVl|82280554|sp|090524|090524_9HrVl|82280552|sp|090522|090522_9fflVl|82280546|sp|090516|090516_9fflVl|82280542|sp|090512|090512_9HIVl|82280540|sp|090510|090510_9HIV 1|82280535|sp|090505|090505_9HIVl|82280532|sp|090502|090502_9HIVl|82280529|sp|090499|090499_9fflVl|82280484|sp|090104|090104_9HIVl Alongada,ιοοιοη/ΐοηΐ^ΐ/Λοηηδοιηοηη«ο οτττνΐ

www^jv^ ----- -

|82280476|sp|090071|090071_9HIVl|82280473|sp|089964|089964_9HIVl|8228047 l|sp|089945|089945_9HIVl|82280467|sp|089932|089932_9HIVl|82280426|sp|073570Í073570_9ffiVl|82280313|sp|072651|072651_9ffiVl|82280311 |sp|072649|072649_9HIVl|82280309|sp|072647|072647_9HTVl|82280307|sp|072645|072645_9HIVl|82280305|sp|072643|072643_9mVl|82280303|sp|072640|072640_9HIVl|82280301 |sp|072638|072638_9HIVl|82280299|sp|072636|072636_9HIVl|82280297|sp|072634|072634_9HIVl|82280295|sp|072632|072632_9HIVl|82280293|sp|072630|072630_9HIVl|8228029 l|sp|072628|072628_9HrVl|82280289|sp|072626|072626_9EQVl|82280287|sp|072624|072624_9HIVl|82280285|sp|072622|072622_9HIVl|82279875|sp|071127|071127_9HIVl|82279873|sp|071125|071125_9HIV1|82279868|sp|071087|071087_9HIVl|82279866|sp|071085|071085_9HIVl|82279630|sp|040603|040603_9HIVl182279628|sp|0406011040601_9HIV|82279626|sp|040599|040599_9HIVl|82279624|sp|040597|040597_9HIVl|82279622|sp|040595|040595_9HIVl|82279621 |sp|040594|040594_

|82279619|sp|040592|040592_

|82279617|sp|040590|040590_

|82278692|sp|012165|012165_

(78 l00208|gb|ABB20911.11,

|74273468|gb|AB AO1450.11,

|74273439|gb|ABA01424.1|,

|74273409|gb|AB AO1397.11,

|74273370|gb|AB AOl 363.1|,

|74315787|gb|ABA02509.1 j,

|74315757jgb j AB A02482.1 |,

|64310552|gb|AAY41247.1|,

l71801566lgblAAZ41739.ll,

|71801559|gb|AAZ41736.1|,

|71801553|gb|AAZ41733.1|,

|71801544|gb|AAZ41730.1|,

|71801538|gb|AAZ41727.1|,

|71801532|gb|AAZ41724.1 j,

]71801526|gb!AAZ41721.1!,

Í71801520Í|bÍAAZ41718.l[

|71801514|gb|AAZ41715.1[,

l71801508lgblAAZ41712.ll,

|71801502|gb|AAZ41709.1|,

|71801495|gb|AAZ41706.1|,

|71801488|gb|AAZ41703.1|,

|71801482|gb|AAZ41700.1|,

|71801476|gb|AAZ41697.1|,

|71801470^|ΑΑΖ41694.1|,

|71801464|gb|AAZ41691.1|,

|71801458|gb|AAZ41688.1|,

|71801452|gb|AAZ41685.1|,

|71801445|gb|AAZ41682.1|,

|71801439|gb|AAZ41679.1|,

|71801432|gb|AAZ41676.1|,

|71801426|gb|AAZ41673.1|,

|71801417|gb|AAZ41670.1|,

|71801405|gb|AAZ41667.1|,

|71801399|gb|AAZ41664.1|,

|71801393|gb|AAZ41661.1|,

|71801387|gb|AAZ41658.1|,

|71801381|gb|AAZ41655.1|,

|71801375|gb|AAZ41652.1|,

|71801369|gb|AAZ41649.11,

|71801362|gb|AAZ41646.1|,

|71801354|gb|AAZ41643.1|,

|71801348|gb|AAZ41640.1|,

|71801341 |gb|AAZ41637.1|,

|71801332|gb|AAZ41634.1|,

9HIV1,9HIV1,9HIV1,9HTV1,74273487|gb|ABA01467.11,74273457|gb|ABA01440.1|,74273429|gb|ABA01415.1|,74273399|gb|ABA01388.1|,74273366|gb| ABAOl 360.11,74315777|gb|AB A02500.11,74315747|gb|AB A02473.11,62946408|gb|AAY22385.1|,71801564|gb|AAZ41738.1|,71801557|gb|AAZ41735.1|,71801551|gb|AAZ41732.1|,71801542|gb|AAZ41729.1|,71801536|gb|AAZ41726.1|,71801530|gb|AAZ41723.1|,71801524|gb \ AAZA1720 1!,71801518|gbÍAAZ41717.l[71801512|gb|AAZ41714.1|,71801506|gb|AAZ41711.1|,71801500|gb|AAZ41708.1|,71801492|gb|AAZ41705.1|,71801486|gb|AAZ41702.1|,71801480|gb|AAZ41699.1|,71801474|gb|AAZ41696.1|,71801468|gb|AAZ41693.1|,71801462|gb|AAZ41690.1|,71801456|gb|AAZ41687.1|,71801450|gb|AAZ41684.1|,71801443 |gb|AAZ41681.1|,71801437|gb|AAZ41678.1|,71801430|gb|AAZ41675.1|,71801424jgb|AAZ41672.1|,71801409|gb|AAZ41669.1|,71801403|gb|AAZ41666.1|,71801397|gb|AAZ41663.1|,71801391|gb|AAZ41660.1|,71801385|gb|AAZ41657.1|,71801379|gb|AAZ41654.1|,71801373|gb|AAZ41651.1|,71801367|gb|AAZ41648.1|,71801360|gb|AAZ41645.1|,71801352|gb|AAZ41642.1|,71801346|gb|AAZ41639.1|,71801338|gb|AAZ41636.1|,71801330|gb|AAZ41633.1|,

|82279620|sp|040593|040593_9HIVl,|82279618|sp|040591|040591_9HIVl,|82279616|sp|040589|040589_9HIVl,|74099689|gb|AAZ28907.1|,|74273478|gb|ABA01459.1|,|74273449|gb|ABA01433.1|,|74273419|gb|ABA01406.11,|74273389|gb|ABA01379.1|,|74273344|gb|ABA01341.1|,|74315767|gb|ABA02491.11,|74315730|gb|ABA02458.11,|71801570|gb|AAZ41740.1|,j71801562|gb|AAZ41737.1|,|71801555|gb|AAZ41734.1|,|71801549|gb|AAZ41731.1|,|71801540|gb|AAZ41728.1|,|71801534|gb|AAZ41725.1|,|71801528|gb|AAZ41722.1|,|71801522!gb!AAZ41719J LÍ71801516ÍgbÍAAZ41716.lí|71801510|gb|AAZ41713.1|,|71801504|gb|AAZ41710.1|,|71801497|gb|AAZ41707.1|5|71801490|gb|AAZ41704.11,|71801484|δ^ΑΑΖ41701.1|,|71801478|gb|AAZ41698.1|,|71801472|gb|AAZ41695.1|,|71801466|gb]AAZ41692.1|,|71801460|gb|AAZ41689.1|,|71801454|gb|AAZ41686.1|,|71801448|gb|AAZ41683.1|,|71801441 |gb|AAZ41680.1|,|71801434|gb|AAZ41677.1|,|71801428|gb|AAZ41674.1|,|71801420|gb|AAZ41671.1|,|71801407|gb|AAZ41668.1|,|71801401 |gb|AAZ41665.11,|71801395|gb|AAZ41662.1|,|71801389|gb|AAZ41659.1|,|71801383|gb|AAZ41656.1|,|71801377|gb|AAZ41653.1|,|71801371 |gb| AAZ41650.1 j,|71801365 jgbj AAZ41647.11,|71801357|gb|AAZ41644.1|,|71801350|gb|AAZ41641.1|,|71801343|gb|AAZ41638.1|,|71801334|gb|AAZ41635.1|,|71801328|gb|AAZ41632.1|,71801326|gb|AAZ41631.171801320|gb|AAZ41628.lj71801314|gb|AAZ41625.1|71801308|gb|AAZ41622.1!71801301|gb|AAZ41619.1j71801292|gb|AAZ41616.1j71801285|gb|AAZ41613.1!71801278|gb|AAZ41610.1|71801271 |gb|AAZ41607. Ij71801265|gb|AAZ41604.1|71801258|gb|AAZ41601.1!71801250|gb|AAZ41598.1j71801243|gb|AAZ41595.1j71801237|gb|AAZ41592.1|7180123 ljgb|AAZ41589.lj71801224|gb|AAZ41586.1|71801214|gb|AAZ41583.1|71801208|gb|AAZ41580.1]

λλλι . ι. i a a γτ λ ι 1 í

/.xj

7l80ll95|gb|AAZ4l574.lj7l80ll89|gb|AAZ4l57l.l|7l80ll83|gb]AAZ4l568.lj7l80ll75|gb|AAZ4l565.l|7l80ll69|gb|AAZ4l562.lj7l80ll63|gb|AAZ4l559.l|71801 l57|gb|AAZ4l556.l|7l80ll5l|gb|AAZ4l553.l|7l80ll44|gb|AAZ4l550.l|7l80ll38|gb|AAZ4l547.l|7l80ll32|gb|AAZ4l544.l|7l80ll23|gb|AAZ4l54l.l|7l80lll7|gb|AAZ4l538.l|7l80llll|gb|AAZ4l535.l|7l80ll02|gb|AAZ4l532.l|7l80l095|gb|AAZ4l529.l|7l80l089|gbjAAZ4l526.l|7l80l083|gb|AAZ4l523.l|7l80l074|gb|AAZ4l520.l|7l80l068|gb|AAZ4l5l7.lj7l80l06l|gb|AAZ4l5l4.l|7l80l055|gb|AAZ4l5ll.l|7l80l049|gb|AAZ4l508.l|7l80l040|gb|AAZ4l505.l|7l80l034|gb|AAZ4l502.l|7l80l028|gb|AAZ4l499.l|7l80l022|gb|AAZ4l496.l|7180l0l6|gb|AAZ4l493.1 [7l80l008|gb|AAZ4l490.l|

7l80l324|gb|AAZ4l630.l7l80l3l8|gb|AAZ4l627.l7l80l3l2|gb|AAZ4l624.l7l80l306|gb|AAZ4l62l.l7l80l298|gb|AAZ4l6l8.l7l80l289|gb|AAZ4l6l5.l7l80l283|gb|AAZ4l6l2.l7l80l276|gb|AAZ4l609.l7l80l269|gb|AAZ4l606.l7l80l263|gb|AAZ4l603.l7l80l255|gb|AAZ4l600.l7l80l247|gb|AAZ4l597.l7l80l24l|gb|AAZ4l594.l7l80l235|gb|AAZ4l59l.l7l80l229|gb|AAZ4l588.l7l80l222|gb|AAZ4l585.l7l80l2l2|gb|AAZ4l582.l7l80l206|gb|AAZ4l579.l

λ ΟΛ1 ι r\r\í IA a τ λ λ cn £ ·%/ IOUl i^^j^üj/Vrt^H-l J /u.l

71801193|gb|AAZ41573.171801187|gb|AAZ41570.171801181|gb|AAZ41567.171801173|gb|AAZ41564.171801167|gb|AAZ41561.171801161 |gb|AAZ41558.171801155[gb|AAZ41555.171801149|gb|AAZ41552.171801142|gb|AAZ41549.171801136|gb|AAZ41546.171801130|gb|AAZ41543.171801121 |gb|AAZ41540.171801115|gb|AAZ41537.171801107[gb|AAZ41534.171801100|gb|AAZ41531.171801093|gb|AAZ41528.171801087|gb|AAZ41525.171801078|gb|AAZ41522.171801072|gb|AAZ41519.171801066|gb|AAZ41516.171801059|gb|AAZ41513.171801053|gb|AAZ41510.171801045|gb|AAZ41507.171801038|gb|AAZ41504.171801032|gb|AAZ41501.171801026|gb|AAZ41498.171801020|gb IAAZ41495.171801014|gb|AAZ41492.171801004|gb|AAZ41489.1

71801322|gb|AAZ41629.171801316|gb|AAZ41626.171801310jgb|AAZ41623.171801304|gb|AAZ41620.171801296|gb|AAZ41617.171801287|gb|AAZ41614.171801281|gb|AAZ41611.171801273|gb|AAZ41608.171801267|gb|AAZ41605.171801260|gb|AAZ41602.171801252|gb|AAZ41599.171801245|gb|AAZ41596.171801239|gb|AAZ41593.171801233|gb|AAZ41590.171801226|gb|AAZ41587.171801219|gb|AAZ41584.171801210|gb|AAZ41581.171801204|gb|AAZ41578.1

ΠΛ ΟΛ1 1 n^f^Ul A A rZA 1 ZHZ 1/ xuv li? / Iguj-Tvrw-TT A./ / χ

71801191|gb|AAZ41572.171801185|gb|AAZ41569.171801179|gb|AAZ41566.171801171|gb|AAZ41563.171801165|gb|AAZ41560.171801159|gb|AAZ41557.171801153|gb|AAZ41554.171801147|gb|AAZ41551.171801140|gb|AAZ41548.171801134|gb|AAZ41545.171801126|gb|AAZ41542.171801119|gb|AAZ41539.171801113|gb|AAZ41536.171801105|gb|AAZ41533.171801097|gb|AAZ41530.171801091|gb|AAZ41527.171801085|gb|AAZ41524.171801076|gb|AAZ41521.171801070|gb|AAZ41518.171801064|gb|AAZ41515.171801057|gb|AAZ41512.171801051|gb|AAZ41509.171801043|gb|AAZ41506.171801036|gb|AAZ41503.171801030|gb|AAZ41500.171801024|gb|AAZ41497.171801018|gb|AAZ41494.171801012|gb|AAZ41491.171801001|gb|AAZ41488.171800999|gb|AAZ41487.11,

71800993|gb|AAZ41484.1|,

71800986|gb|AAZ41481.11,

71800978|gb|AAZ41478.1|,

71800972|gb|AAZ41475.1 j,

71800964|gb|AAZ41472.11,

71800954|gb|AAZ41469.1|,

71800948|gb|AAZ41466.1|,

71800942|gb|AAZ41463.1|,

71800936|gb|AAZ41460.1|,

71800928|gb|AAZ41457.1|,

71800922|gb| AAZ41454.1 j,

71800916|gb|AAZ41451.1|,

71800910|gb|AAZ41448.1|,

71800902|gb|AAZ41445.1|,

71800895|gb|AAZ41442.1|,

71800886|gb|AAZ41439.1|,

71800876|gb|AAZ41436.1|,

71800870|gb|AAZ41433.1|,

71800864|gb|AAZ41430.1|,

71800856|gb|AAZ41427.1|,

71800849|gb|AAZ41424.11,

71800843|gb|AAZ41421.1|,

71800837|gb|AAZ41418.1|,

7180083 0|gb|AAZ41415.11,

71800822|gb|AAZ41412.1|,

71800815|gb|AAZ41409.1|,

71800809|gb|AAZ41406.1|,

71800800|gb|AAZ41403.11,

71800792|gb]AAZ41400.1|3

71800783|gb|AAZ41397.1|,

71800774|gb|AAZ41394.1|,

71800768lgbjAAZ41391.lt

71800762|gb|AAZ41388.1|,

71800756|gb|AAZ41385.1|,

57869718|gb|AAW57753.1|,

57869691 |gb|AAW57729.11,

57869662|gb| AAW57703.il,

57869633 jgbj AAW57677.11,

57869606|gb|AAW57653.1|,

57869577|gb|AAW57627.1 j,

|71800997|gb|ÀAZ41486.1|,|71800990|gb|AAZ41483.1|,|71800982|gb|AAZ41480.11,|71800976|gb|AAZ41477.1|,|71800969|gb|AAZ41474.11,|71800962|gb| AAZ41471.11,|71800952|gb|AAZ41468.1|,|71800946|gb|AAZ41465.1|,|71800940|gb|AAZ41462.11,|71800932|gb|AAZ41459.1|,|71800926|gb|AAZ41456.1|,|71800920|gb| AAZ41453.1|S|71800914|gb|AAZ41450.1|,|71800908|gb|AAZ41447.1|,|71800899|gb|AAZ41444.1|,|71800892|gb|AAZ41441.1|,|7180088 l|gb|AAZ41438.1|,|71800874|gb|AAZ41435.lj,|71800868jgb|AAZ41432.1|,|71800862|gb| AAZ41429.11,|71800854|gb| AAZ41426.1 j,|71800847|gb|AAZ41423.1|3|71800841|gb|AAZ41420.1|,|71800834|gb|AAZ41417.1|,|71800827|gb|AAZ41414.1|,|71800820|gb|AAZ41411.1|,|71800813|gb|AAZ41408.1|,|71800804|gb|AAZ41405.1|,|71800798|gb|AAZ41402.1|,|71800788|gb|AAZ41399.1|,|71800780|gb|AAZ41396.1|,|71800772|gb|AAZ41393.1|,|71800766|gb|AAZ41390.11,|71800760|gb|AAZ41387.1|,|57869736|gb|AAW57769.1|,|57869709|gb|AAW57745.1|,|57869682|gb|AAW57721.11,|57869652|gb|AAW57694.1|,|57869625|gb|AAW57670.1|,|57869596|gb|AAW57644.1|,|57869567|gb|AAW57618.1|,

57869550|gb|AAW57603.1|,18699176|gb|AAL78441.1 |AF413982_4,18699164|gb| AAL78431.1 |AF413980_2,55740262|gb|AAV63833.1|, |55740253|gb|AAV63825.1|,55740234|gb|AAV63808.1|, |45361207|gb|AAS59398.1|,45361174|gb|AAS59378.1|, |45361154|gb|AAS59366.1|,45361131 |gb|AAS59349.11, |45361121 |gb| AAS59340.1 j,

|71800995|gb|AAZ41485.1|,|71800988|gb|AAZ41482.1|,|*71800980|gb|AAZ41479.1 j,|71800974|gb|AAZ41476.1 j,|71800966|gb|AAZ41473.1|,|71800957|gb|AAZ41470.1|,|71800950|gb|AAZ41467.1|,|71800944|gb|AAZ41464.11,|71800938|gb|AAZ41461.1|,|71800930|gb|AAZ41458.1|,|71800924|gb|AAZ41455.1|,|71800918|gb|AAZ41452.1|,l71800912lgblAAZ41449.ll,|71800905|gb|AAZ41446.1|3|71800897|gb|AAZ41443.1 j,|71800888|gb|AAZ41440.1|,|71800879|gb|AAZ41437.1|,|71800872|gb|AAZ41434.1|,j7i8008óó|gbjAAZ4i431.1|,|71800858|gb|AAZ41428.1|,|71800852|gb|AAZ41425.1|,|71800845|gb|AAZ41422.1|,|71800839|gb|AAZ41419.1|,|71800832|gb|AAZ41416.1|,|71800825|gb|AAZ41413.1|,|71800818|gb|AAZ41410.1|,|7180081 l|gb|AAZ41407.1|,|71800802|gb|AAZ41404.1 j,|71800796|gb|AAZ41401.11,|71800785|gb|AAZ41398.1|,|71800776|gb|AAZ41395.1|,|71800770|gb|AAZ41392.1|,|71800764|gb|AAZ41389.1|,|71800758|gb|AAZ41386.1|,|57869727|gb|AAW57761.11,|57869701 |gb|AAW57738.11,|57869672|gb|AAW57712.1|,|57869642|gb|AAW57685.11,|57869615 |gb|AAW57661.11,|57869587|gb|AAW57636.1|,|57869559|gb|AAW57611.1|,118699244|gb| AAL78486.1 |AF414005_2,|18699168|gb|AAL78434.1|AF413981_l,|60218872|gb|AAX14850.1|,|55740244|gb|AAV63817.1|,|45361195|gb|AAS59389.1|,|45361143|gb|AAS59358.1|,|45361109|gb|AAS59331.1|,|45361097|gb|AAS59322.11,l62467722lgbjAAX83975.il,|52421751|gb|AAU45387.1|,|51950728|gb|AAU14920.1|,|2570005|emb|CAA75393.1|,|2569999|emb|CAA75390.1j,|2569993|emb|CAA75387.1|,|60120|emb|CAA44768.11,|21425745|emb|CAD23404.1|21425739|emb|CAD23401.1|21425733|emb|CAD23398.1|21425727|emb|CAD23395.1|21425721|emb|CAD23392.1|21425715|emb|CAD233 89.1|21425709|emb|CAD23386.1|21425703|emb|CAD23383.1|21425697|emb|CAD23380.1|609315 5 |emb|CAB5 8987.1 j,|6093140|emb|CAB59010.1 j,|26000282|gb| AAN75315.11,|25167058|gb|AAN73824.1 |AF484520_8|25167038|gb|AAN73806.1 |AF484518_8|25167018|gb|AAN73788.1 |AF484516_8|25166998|gb|AAN73770.1|AF484514_8|25166978|gb|AAN73752.1|AF484512_8|25166958|gb|AAN73734.1|AF484510_8|2516693 8 |gb| AAN73716.1 |AF484508_8\25166918|gb|AAN73698.11AF484506_8|25166888|gb|AAN73671.1|AF484503_8|25166858|gb|AAN73644.1|AF484500_8|25166838|gb|AAN73626.1|AF484498_8125166818|gb|AAN73608.1 |AF484496_8|25166798|gb|AAN73590.1|AP484494_8|25166778|gb|AAN73572.1 |AF484492_8|25166758|gb|AAN73554.1 |AF484490_8|25166738igb|AAN73536.1|AF484488_8|25166718jgb j AAN73 518.1|AF484486_8|25166696|gb|AAN73499.1|AF484483_8|25166676|gb|AAN73481.1 |AF484481_8|25166656|gb| AAN73463.1 |AF484479_8|25166637|gb|AAN73446.1 |AF484477_9|41353560|gb|AAS01347.1|,|55735983|gb|AAV59713.1|,|55735956|gb| AAV59689.1|36365542|gb|AAQ86746.1|,136365515lgblAAQ86722.ll,|36365488|gb|AAQ86698.11,|36365461 |gb|AAQ86674.11,

|45361083|gb|AAS59313.1|,|6246771 l|gb|AAX83965.1|,|52421740|gb|AAU45379.1|,|51950718|gb|AAU14911.1|,|2570003 |emb|CAA75392.11,|2569997|emb|CAA75389.1|,|60124|emb|CAA44770.11,|60118|emb|CAA44767.1|,|21425743 |emb|C AD23403.11,|21425737|emb|CAD23400.1|,|21425731|emb|CAD23397.1|,|21425725|emb|CAD23394.1|,|21425719|emb|CAD23391.1|,|21425713|emb|CAD23388.1|,|21425707|emb|CAD23385.1|,|21425701|emb|CAD23382.1|,|21425695|emb|CAD23379.1|,|6093150|emb|C AB5 8983.11,|5763680jembjCÁB53243.ii,|26000272|gb|AAN75306.1|,

|45361073|gb|AAS59304.1|162467701 |gb|AAX83956.11|62467694|gb|AAX83950.11|3724197|emb|CAA77077.1||2570001|emb|CAA75391.1||2569995|emb|CAA75388.11|60122|emb|CAA44769.1||21425747|emb|CAD23405.1|121425741 |emb|CAD23402.11|21425735|emb|CAD23399.1||21425729|emb|CAD23396.1||21425723|emb|CAD23393.1||21425717|emb|CAD23390.1|12142571 l|emb|CAD23387.11|21425705|emb|CAD23384.1||21425699|emb|CAD23381.11|6093160|emb|CAB58991.1||6093145|emb|CAB58979.11

-ι m ι k r\/rοι T 1

μζδδ jy / Iemoj^-ZVrt-Uoo ι /. 11

|26000262|gb|AAN75297.1

8_88_88

|25167048|gb| AAN73 815.1|25167028|gb|AAN73797.1|25167008|gb|AAN73779.1|25166988|gb|AAN73761.1|25166968|gb|AAN73743.1|25166948|gb|AAN73725.1|25166928|gb|AAN73707.1|25166898|gb|AAN73680.1|25166868|gb|AAN73653.1|25166848|gb|AAN73635.1|25166828|gb|AAN73617.1|25166808|gb|AAN73599.1|25166788|gb|AAN73581.1|25166768|gb|AAN73563.1|25166748|gb|AAN73545.1|25166728|gb|AAN73527.1|25166708|gb|AAN73509.1|25166686|gb|AAN73490.1|25166666|gb|AAN73472.1|25166646|gb| AAN73454.1

155736001 |gb|AAV59729.1|,|55735974|gb|AAV59705.1|,|45644397|gb|AAS72951.11,|36365533|gb|AAQ86738.1|,|36365506|gb|AAQ86714.1|,|36365479|gb|AAQ86690.1|,|36365452|gbjAAQ86666.1|,

AF484519AF484517AF484515AF484513AF484511_AF484509_8AF484507_8AF484504_8AF484501_8AF484499_8AF484497_8AF484495_8AF484493_8AF484491_8AF484489_8AF484487_8AF4844858AF484482_8AF484480_8|AF484478_8123194115|gb|AAN15023.1|55735992|gb|AAV59721.1|55735965|gb|AAV59697.1|36365551 |gb|AAQ86754.1|36365524|gb|AAQ86730.1|36365497|gb|AAQ86706.1|36365470|gb|AAQ86682.1|36365443|gb|AAQ86658.1|36365434|gb|AAQ86650.1|36365407|gb|AAQ86626.1|36365380|gb|AAQ86602.1|46946866|gb|AAT06654.11|46946833|gb|AAT06625.11|40021869|gb|AAR37185.1|

|40021839|gb|AAR37164.1

|40021809|gb|AAR37143.1

|40021779|gb|AAR37122.1

|40021749|gb|AAR37101.1

|40021719|gb|AAR37080.1

|47027396|gb|AAT08776.1

|29409307|gb|AAM67386.1

|39777432|gb|AAR31009.1

|39777402|gb|AAR30982.1

|38426984|gb|AAR20515.1

|38426978|gb|AAR20512.1

]38426972!gblAAR20509.1

Í38426966jgb|AAR20506.1

|38426962|gb|AAR20504.1

|38426956|gb| AAR20501.1

|38491923|gb|AAR22288.1

|38491897|gb|AAR22265.1

138491868|gb|AAR22239.1

|38491839|gb|AAR22213.1

|38491809|gb|AAR22186.1

|38491779|gb|AAR22159.1

|38491752|gb|AAR22135.1

|38491721|gb|AAR22108.1

|38491676|gb|AAR22068.1

|38491646|gb| AAR22041.1

|38491613|gb|AAR22012.1

|38491584|gb|AAR21986.1

|38491554|gb|AAR21959.1

|38491527|gb|AAR21935.1

|38491488|gb|AAR21900.1

|37683025|gb|AAQ98583.1

|37682996|gb| AAQ98557.1

|37682966|gb|AAQ98530.1

|37682936|gb|AAQ98503.1

|37682908|gb|AAQ98478.1

|37682869|gb| AAQ98446.1

|37682839|gb|AAQ98419.1

|37682809|gb|AAQ98392.1

|37682779|gb|AAQ98365.1

|37682749|gb|AAQ98338.1

|37682719|gb|AAQ98311.1

|33331473|gb|AAQ10918.1

roncada,

|36365425|gb|AAQ86642.1|,|36365398|gb|AAQ86618.1|,|5619303 l|gb|AAV84126.1|,|46946850|gb|AAT06640.11,|40021889|gb|AAR37199.1|,|40021859|gb|AAR37178.1|,|40021829|gb|AAR37157.1|,|40021799|gb|AAR37136.1|,|40021769|gb|AAR37115.1|,|40021739|gb|AAR37094.1|,|40021709|gb|AAR37073.1|,|29409334|gb|AAM67410.11,|29409303|gb| AAM673 83.11,|39777422|gb| AAR31000.11,|39777392|gb|AAR30973.1|,|3 8426982|gb| AAR20514.11,|38426976|gb| AAR20511.11,|38426970|gb|AAR20508.1|,

|38426960|gb|AAR20503.1|,

|38491944|gb|AAR22307.1|,

|38491914|gb|AAR22280.1|,

l38491888lgblAAR22257.ll,

|38491858|gb|AAR22230.1|,

|38491829|gb|AAR22204.11,

|38491799|gb|AAR22177.1|,

|38491769|gb|AAR22150.11,

|38491742|gb|AAR22126.1|3

|38491711 |gb|AAR22099.11,

|38491666|gb|AAR22059.1|,

|38491636|gb|AAR22032.1|,

|38491603|gb|AAR22003.1|,

|38491574|gb|AAR21977.1|,

|38491544|gb|AAR21950.1|,

|38491508|gb|AAR21918.1|,

|37683045|gb|AAQ98601.1|,

|37683015|gb|AAQ98574.1|,

|37682986|gb|AAQ98548.1 j,

|37682956|gb|AAQ98521.11,

|37682926|gb| AAQ98494.11,

|37682897|gb|AAQ98469.1 j,

l37682859lgbjAAQ98437.il,

|37682829|gb|AAQ98410.1 j,

|37682799|gb|AAQ98383.1|,

|37682769|gb|AAQ98356.1|,

|37682739|gb|AAQ98329.1|,

|37682709|gb|AAQ98302.1 j,

|33331463|gb|AAQ10909.1|,

|36365416|gb|AAQ86634.1|

|36365389|gb|AAQ86610.1|

|56131608|gb|AAV80388.1|

|46946842|gb|AAT06633.1|

|40021879|gb|AAR37192.1|

|40021849|^|AAR37171.1|

|40021819|gb|AAR37150.1|

|40021789|gb|AAR37129.1|

|40021759|gb|AAR37108.1|

|40021729|gb|AAR37087.1)

|40021699|gb|AAR37066.1|

|29409322|gb|AAM67400.1

|39777442|gb|AAR31018.1

|39777412|gb|AAR30991.1

|39777382|gb|AAR30964.1

|38426980|gb|AAR20513.1

|38426974|gb|AAR20510.1

j38426968|gb|AAR20507.1

|3842ó9ó4igbjAAR20505.1

|38426958|gb|AAR20502.1

|38491934|gb|AAR22298.1

|38491907|gb| AAR22274.1

|38491878|gb|AAR22248.1

|3 8491849|gb|AAR22222.1

|38491819|gb|AAR22195.1

|38491789|gb|AAR22168.1

|38491762|gb|AAR22144.1

|38491731|gb|AAR22117.1

|38491695|gb|AAR22085.1

|38491656|gb|AAR22050.1

|38491626|gb|AAR22023.1

|3 8491594|gb|AAR21995.1

|38491564|gb|AAR21968.1

|38491534|gb|AAR21941.1

|38491498|gb|AAR21909.1

|37683035]gb|AAQ98592.1

|37683006|gb|AAQ98566.1

|37682976|gb|AAQ98539.1

|37682946|gb|AAQ98512.1

|37682918|gb|AAQ98487.1

|37682887|gb|AAQ98460.1

|37682849|gb|AAQ98428.1

|37682819|gb|AAQ98401.1

|37682789|gb|AAQ98374.1

|37682759|gb|AAQ98347.1

|37682729|gb|AAQ98320.1

|33331483|gb|AAQ10927.1

|44194557|gb|AAS46887.1|44l94555|gb|AAS46886.1|,|44194549|gb|AAS46883.11,|4336345|gb|AAD17771.1|,l22003833lgblAAM88880.ll,|22003827|gb]AAM88877.1|,|22003821 |gb|AAM88874.1 j,|22003 813 |gb|AAM88871.1 j,|37909408|gb| AA065569.1|3793 5967|gb|AA047206.11,|37935938|gb|AA047180.1 j,|37935907|gb|AA047153.1|,|37935878|gb|AA047128.1 j,|37935848|gb|AA047101.1|,134811841|gb|AA040784.1|,.|28933410|gb|AA062624.1 |AF468970_9,

|44194553|gb|AAS46885.1|,|44194547|gb|AAS46882.1 j,|4336336|gb|AAD17762.1|,|22003831 |gb|AAM88879.11,|22003825)gb|AAM88876.1|,|22003819|gb|AAM88873.1|,|2200381 l|gb|AAM88870.1|,|37935987|gb|AA047224.1|,|37935958|gb|AA047198.1|,|37935928|gb|AA047171.1|,|37935898|gb|AA047145.1|,|37935868|gb|AA047119.11,|30269373 |gb|AAP29651.11,

|23394926|gb|AAN31648.1|32344844|gb|AAM82300.1|,|33328196|gbj AAQ09545.11,|25807928|gbjAAN74516.1j,|29119332|gb|AA063247.1|,|29119304|gb|AA063222.1|3Í29119274|gb|AA063195.lÍ,|29293585|gb|AA072219.1|,|29293578|gb|AA072216.11,|29293571|gb|AA072213.1|,|29293564jgbj AA072210.1j,|29293558|gb|AA072207.11,|29293552|gb|AA072204.11,|29293546jgb|AA072201.1 j,l29293540lgblAA072198.ll,|29293532|gb|AA072195.1],|29293526|gb|AA072192.11,|29293519|gb|AA072189.11,|29293509|gb|AA072186.1 j,|29293503jgb j AA072183.11,|29293497|gb|AA072180.1|,|29293491 |gb|AA072177.11,|29293485|gb|AA072174.1|,|29293478|gb|AA072171.1 j,|29293472|gb|AA072168.1|,l29293466lgblAA072165.ll,|29293458|gb|AA072162.1|,|22074598|gb|AAL82561.11,j22074590|gb|AAL82558.1|,|22074577|gb|AAL82555.11,|22074561 |gb|AAL82552.11,|22074550|gb|AAL82549.1 j,|22074539|gb|AAL82546.11,

|33390887|gb|AAQ17106.1|,|33328328|gb|AAQ09617.1|,|30720414|gb|AAP33682.1|,j29119350jgb|AA063263al!i|29119323ÍgbÍAA063239.lí|29119294|gb j AA063213.1 j,|29119262|gb|AA063184.11,|29293583|gb|AA072218.1|,|29293576|gb|AA072215.1 j,|29293569|gb|AA072212.1 j,|29293562|gb|AA072209.1|,|29293556|gb|AA072206.11,|2929355ojgb | AA072203.11,|29293544|gb|AA072200.11,|29293538|gb|AA072197.1|,|29293530|gb|AA072194.1|,|29293524|gb|AA072191.1|,|29293517|gb|AA072188.1|5|29293507|gb|AA072185.1|,|29293501 jgb|AA072182.1 j,|29293495|gb|AA072179.11,|29293489|gb|AA072176.1|,|29293483jgbj AA072173.1 j,|29293476|gb | AA072170.1 j,|29293470jgb|AAO72167.1|,Í29293464jgb|AA072164.lj,|26518645|gb|AAN83919.11,Í22074595jgbjAAL82560.11,Í22074586|gbÍAAL82557.lj,|22074572|gbÍAAL82554.lj,Í22074557jgbjAAL82551.11,|22074546|gb j AAL82548.11,Í22074535jgb|AAL82545.1 j,

|44194551|gb|AAS46884.1||44194545|gb|AAS46881.1||22003835|gb|AAM88881.ljÍ22003829|gbjAAM88878.1|j22003823|gbÍAAM88875.1||22003815jgbjAAM88872.lj|37935587|gb|AA065560.lj|37935977jgbjAA047215.lj|37935948|gbjAA047189.1|j37935918ÍgbjAA047162.lj|37935887|gb|AA047136.1||37935858|gb|AA047110.1||37725246|gb|AAR02309.1||32189806|gb|AAP75717.1||23394933|gb|AAN31654.1||32344854|gb|AAM82309.1||33328206|gb|AAQ09554.1||25807938|gb|AAN74525.1||29119337|gblAA063251.1|j29119313ÍgbjAA063230.1||29119284|gb|AA063204.11|29293587|gb|AA072220.1||29293581|gb|AA072217.1||29293573|gb|AA072214.1||29293567|gb|AA072211.11|29293560|gb|AA072208.1 j|29293554|gb|AA072205.11|29293548|gb|AA072202.1||29293542|gb|AA072199.11|29293536|gb|AA072196.1||29293528|gb)AA072193.1||29293522|gb|AA072190.11|2929351 l|gb]AA072187.1||29293505|gb|AA072184.1||29293499|gb|AA072181.1 j|29293493 |gb|AA072178.1 j|29293487|gb|AA072175.1||29293480|gb|AA072172.11|29293474|gb|AA072169.1||29293468|gb|AA072166.1||29293460|gb |AA072163.1 j|22074615|gb|AAL82562.1||22074593|gb|AAL82559.11|22074582|gbjAAL82556.1||22074565|gb|AAL82553.1||22074554|gb|AAL82550.1||22074542|gb|AAL82547.1 j|22074529|gb|AAL82544.1|22074520|gb|AAL82543.24754012|gb|AAN64130,24753980|gb|AAN64103,24181516|gb|AAN47135.24181486)gb|AAN47108,22596572|gb|AAN0332722596552|gb|AAN0330922596532|gb|AAN0329122596512|gb|AAN0327322596492|gb|AAN0325522596472|gb|AAN0323722596452|gb|AAN0321922596427|gb|AAN0319822596406|gb|AAN0318022596386|gb|AAN0316222596366|gb|AAN0314422596346|gb|AAN0312622596326|gb|AAN0310822596306jgbiÀAN03090

1], |22074458|gb|AAL82542.1|, |22074454|gb|AAL82541.1|,

1|, |24754002|gb|AAN64121.11, |24753991|gb|AAN64112.1|,

1|, |24753969|gb|AAN64094.1|, |24753958|gb|AAN64085.1|,

1|, |24181506|gb|AAN47126.1|, |24181496|gb|AAN47117.1|,

II,

1|AF457089_9,1 |AF457087_9,1 |AF457085_9,1|AF457083_9,1|AF457081_9,,1|AF457079_9,11AF457077_9,,1|AF457073_9,,1|AF457070_9,1|AF457068_9,,1|AF457066_9,1|AF457064_9,1|AF457062_9,ljAF457060_ 4.

|22596582|gb|AAN03336.1|AF457090_9,|22596562|gb|AAN03318.1|AF457088_9,|22596542|gb|AAN03300.1|AF457086_9,|22596522|gb|AAN03282.1|AF457084_9,l22596502|gblAAN03264.1 |AF457082_9,|22596482|gb|AAN03246.1|AF457080_9,|22596462|gb| AAN03228.1 |AF457078_9,|22596439|gb|AAN03208.1|AF457075_9J|22596417|gb|AAN03189.1 |AF457072_9,|22596396|gb|AAN03171.1 |AF457069_9,|22596376|gb|AAN03153.1 |AF457067_9,|22596356|gb|AAN03135.1|AF457065_9,l22596336|gb|AAN03117.1 |AF457063_9,122596316|gb|AAN03099.1 |AF457061_9,|225S6301 jgb JAAN03086.1 |AF457059_9,

22596291 |gb|AAN03077.1|AF457058_9,22596270|gb|AAN03059.1 |AF457055_9,22596250|gb|AAN03041.1 |AF457053_9,22596230Ígb|AAN03023.1|AF457051_9,2286141 |gb|AAB64287.1|, 12286132|gb|AAB64279.1|,17902145|gb|AAL47810.1|, |17902134|gb|AAL47801.1|,17902112|gb|AAL47783.1|, 117902101|gb|AAL47774.lj,17864049|gbí AAL47043.11,22532300|gb|AAM97893.1 |AF492624_9,22532148|gb|AAM97859.1|AF460974_9,

22297048|gb|AAM94504.11,

463064lgb| AAA99884.11,

71726040|gb|AAZ39169.1|,

71726010lgblAAZ39142.ll,

71725980lgblAAZ39115.ll,

83026821 |gbjABB96456.1|,

83026793 |gb|ABB96431.1],

825714Í4|gb|ABB84171.1|,

82571385|gb|ABB84145.1|,

82571357|gb|ABB84120.1|,

82571327|gb|ABB84093.1|,

82571297|gb|ABB84066.11,

82571267|gb|ABB84039.1|,

82571238jgbj ABB84013.1 j,

82571209|gb|ABB83987.1|,

55560592|gb|AAV53164.11,

55560586|gb|AAV53161.11,

55560580|gb|AAV53158.1|,

55560574|gb|AAV53155.1|,

|902807|gb| AAB60579.11,|328908|gb|AAA75023.1|,|71726030|gb|AAZ39160.1|,|71726000|gb|AAZ39133.1|,1717259701gblAAZ39106.1|5|83026813|gb|ABB96449.1|,|83026783 |gb|ABB96422.11,|82571404|gb|ABB84162.1|,|82571377|gb|ABB84138.1|,|82571347|gb|ABB84111.11,|82571317|gb|ABB84084.1|,|82571287|gb|ABB84057.1|,]82571258|gb|ABB84031.1|,|82571228|gb|ABB84004.1|,|82571199|gb|ABB83978.1|,|55560590|gb|AAV53163.1|,|55560584|gb|AAV53160.1|,|55560578|gb|AAV53157.11,155560572|gb|AAV53154.1|,

|22596280lgb|AAN03068.1|AF457056_9,]22596260|gb|AAN03050.1|AF457054_9,l22596240|gb|AAN03032.1|AF457052_9,|20513087lgb|AAM21153.1|,|17902156|gblAAL47819.1|,|17902123|gb|AAL47792.1|,|17864059|gb|AAL47052.1|,117864039|gb|AAL47034.11,|22532290]gb|AAM97884.1 |AF492623_9,|22532139|gb|AAM97851.1|AF460972_9,

|818223|gb|AAB47935.1|,|71726050|gb|AAZ39178.1|,|71726020|gb| AAZ39151.1),|71725990|gb|AAZ39124.1|,|71725960|gb| AAZ39097.1 ],|83026803|gb|ABB96440.1|,|62461844|gb|AAX83060.1|,|82571393|gb|ABB84152.1|,|82571367lgb|ABB84129.1|,|82571337|gb|ABB84102.1|,|82571307|gb|ABB84075.1|,|82571277|gb|ABB84048.1|,|82571248|gb|ABB84022.1|,|82571218|gb|ABB83995.1|,|55560594|gb|AAV53165.1|,|55560588|gb|AAV53162.1|,|55560582|gb|AAV53159.1|,|55560576|gb|AAV53156.1|,|55560570|gb|AAV53153.1|,|55560568|gb|AAV53152.1|55560562|gb|AAV53149.1|55560556[gb|AAV53146.1[55560550|gb|AAV53143.1[55560543 |gb|AAV53140.1|55560537|gb|AAV53137.1[5556053 ljgb|AAV53134.1|55560525|gb|AAV53131.1'[55560519|gb|AAV53128.1[55560513|gb]AAV53125.1|55560507|gb|AAV53122.1|5556050ljgb]AAV53119.1|55560495|gb]AAV53116.1|55560489|gbjAAV53113.i;|55560483]gb|AAV53110.lj|55560477]gb|AAV53107,l||55560471 jgb|AAV53104.1 j|55560465|gb|AAV53101.1|!55560459lgblAAV53098.1||55560453jgbjAAV53095.11)55560447|gb|AAV53092.1 j[55560441 |gb|AAV53089.1 j}55560435|gb]AAV53086.1 j|55560429]gb]AAV53083.1 jj55560422|gb[AAV53080.11155560416|gb[AAV53077.11[55560410|gb|AAV53074.11[55560403 |gb|AAV53071,11|55560397|gb|AAV53068.1|155560391 |gb|AAV53065.1 j|55560385]gb]AAV53062.lj|55560379|gb| AAV53059.1 ]|55560373|gb|AAV53056.1|]55560366[gb|AAV53053.1|]55560360]gb|AAV53050.1|j55560354|gb|AAV5 3047.1 j|55560348|gb|AAV5 3044.1]|55560342|gb|AAV53041.1|j55560336|gb[AAV53038.1]|55560330[gb[AAV53035.11|55560324|gb|AAV53032.lj|55560318|gbjAAV53029. Ij|55560312jgbjAAV53026.lj|55560306|gbjAAV53023.1||55560300Jgb|AAV53020.1||55560294]gbJAAV53017.1|]55560288|gb|AAV53014.1|)55560282[gb|AAV53011.1 j

|55560566|gb| AAV53151.11j55560560|gb| AAV53148.11]55560554|gb}AAV53145.1 j|55560547|gb[AAV53142.1 j|55560541 IgbjAAV53139.1 j|55560535|gb|AAV53136.1||55560529|gb|AAV53133.1||55560523jgb|AAV53130.1|j55560517igb|AAV53127.1|15556051 ljgb[AAV53124.1|[55560505 jgb[AAV53121.1 j|55560499jgb|AAV53118.1||55560493[gb|AAV53115.11|55560487[gb|AAV53112.1||55560481 [gb[AAV53109.11|55560475|gb|AAV53106.1||55560469|gbj AAV53103.1 j|55560463[gb]AAV53100.1 j|55560457|gb|AAV53097.1|J55560451 [gb|AAV53094.1 j|55560445[gb|AAV53091.1||55560439[gb|AAV53088.1||55560433[gb|AAV53085.1||55560427[gb|AAV53082.1||55560420[gb|AAV53079.1||55560414[gb|AAV53076.1||55560408[gb|AAV53073.1|155560401 |gb[AAV53070.11|55560395|gb|AAV53067.1||55560389|gb|AAV53064.1||55560383|gb|AAV53061.1||55560377|gb|AAV53058.1|155560371 |gb[AAV53055.11|55560364|gb|AAV53052.1||55560358|gb[AAV53049.1||55560352|gb[AAV53046.1||55560346]gb|AAV53043.1||55560340|gb|AAV53040.1||55560334Ígb|AAV53037.1||55560328 |gb|AAV53034.11|555603221gb|AAV53031.11|55560316|gb|AAV53028.lj|55560310]gb|AAV53025.1||55560304[gb|AAV53022.1||55560298|gb|AAV53019.1[]55560292|gb|AAV53016.lj]55560286[gb|AAV53013.1|[55560280jgb|AAV53010.1]

55560564|gb|AAV53150.1[55560558|gb|AAV53147.1|55560552[gb[AAV53144.1)55560545[gb[AAV53141.lj55560539[gb[AAV53138.1|55560533[gb[AAV53135.1|55560527[gb[AAV53132.1]55560521 |gb|AAV53129.1]55560515|gb|AAV53126.1|55560509|gb|AAV53123.1|55560503|gb[AAV53120.1|55560497|gb|AAV53117.1|55560491 ]gb[AAV53114.1]55560485|gb[AAV53111.1]55560479]gb[AAV53108.1]55560473|gb[AAV53105.1]55560467[gb[AAV53102.1]55560461 [gb[AAV53099.1 j55560455|gb|AAV53096.1]55560449|gb IAAV53093.1155560443|gb|AAV53090.1 j55560437|gb|AAV53087.1[5556043 l|gb|AAV53084.lÍ55560424|gb|AAV53081.lj55560418|gb|AAV53078.1155560412|gb|AAV53075.1|55560406|gb|AAV53072.1|55560399|gb|AAV53069.1|55560393 |gb|AAV53066,l j55560387|gb|AAV53063.1|55560381|gb|AAV53060.1|55560375|gb|AAV53057.1 j55560369|gb|AAV53054.1 j55560362|gb|AAV53051.1155560356|gb|AAV53048.1|55560350|gb|AAV53045.1|55560344|gb|AAV53042.1|55560338|gb|AAV53039.lj55560332|gb|AAV53036.1]55560326|gb|AAV53033.1155560320|gb|AAV53030.1|55560314]gb|AAV53027.1|55560308jgb|AAV53024.1|55560302|gb]AAV53021.1|55560296|gb|AAV53018.1155560290|gb|AAV530l5.1|55560284|gb|AAV53012.1 ]55560278[gb[AAV53009.1 j|55560276|gb|AAV53008.1|,|55560270jgblAAV53005.il,|55560264|gb|AAV53002.1|,|55560258|gb|AAV52999.1|,|55560252|gb|AAV52996.1|,|55560246|gb|AAV52993.1|,|55560240|gb|AAV52990.1|,|55560234|gb|AAV52987.1|,|55560228|gb|AAV52984.1|,|55560222|gb|AAV52981.1|,|55560216|gb|AAV52978.1|,|55560210|gb|AAV52975.1|,|555602041gb|AAV52972.1|,|82322074|sp|Q50D69|Q50D69_9HTVl,|82322069|splQ50D55|Q50D55_9HIVl,|82321270|sp|Q79796|Q79796_9HIVl,

|55560274|gb|AAV53007.1|,|55560268|gb|AAV53004.1|,|55560262|gb|AAV53001.1|,|55560256|gb|AAV52998.1|,|55560250|gb|AAV52995.1|,|55560244|gb|AAV52992.1|,|55560238|gb|AAV52989.1|,|55560232|gb|AAV52986.1|,|55560226|gb|AAV52983.1 j,|55560220|gb|AAV52980.1|,|55560214|gb|AAV52977.1|,|55560208|gb|AAV52974.1|,

|55560272|gb|AAV53006.1|,|55560266|gb|AAV53003.1|,|55560260|gb|AAV53000.1|,|55560254|gb|AAV52997.11,|55560248|gb|AAV52994.1|,|55560242|gb|AAV52991.1|,|55560236|gb|AAV52988.1|,|55560230|gb|AAV52985.1|,|55560224|gb|AAV52982.1|,|55 560218|gb|AAV52979.11,|55560212|gb|AA.V52976.1|,|55560206|gb|AAV52973.1|,|55560202|gb|AAV52971.11,|82322071|sp|Q50D60|Q50D60_9HTVl,|82321274| sp IQ4ZFQ7 |Q4ZFQ7_9HIV 1,|82321025|sp|Q52VK7|Q52VK7_9HTVl,

8ZJ/ÍZ/USP U/y/iO i, Iu^"*""-i"Jfi-<------^ -

82319471 |sp|Q9IW36|Q9IW36_9HIVl, |82319168|sp|Q9IH70|Q9IH70_9HIVlmutante,

82318844|sp|Q9DRR7|Q9DRR7 9HrVltnmcada, |82313427|sp|Q8Q617|Q8Q617_9HIVl,

|82311516|sp|Q7SPQ2|Q7SPQ2_9HlVl,|82310816|sp|Q6YA56|Q6YA56_9HrVl,|82310781 |sp|Q6X6R0|Q6X6R0_9HIVl,|82310769|sp|Q6X6J2|Q6X6J2_9HTVl,|82310761 |sp|Q6X4Q7|Q6X4Q7_9HIVl,|82310755|sp|Q6X4P 1 |Q6X4P 1_9HIV1,|82310750|sp|Q6X4M5|Q6X4M5_9HrVl,|82309836|sp|Q5MH20|Q5MH20_9HIVl,|82309830|sp|Q5MH02|Q5MH02_9HIVl,|82309824|sp|Q5MGY4|Q5MGY4_9fflVl,|82309818|sp|Q5MGW6|Q5MGW6_9HIVl,|82309813 |sp|Q5MGU4|Q5MGU4_9HIV 1,|82309381|sp|Q5C9Y2|Q5C9Y2_9HIVl3|82308944|sp|041886|041886_9HIVl,|82308470|sp|Q9YYU9|Q9YYU9_9HIVl,|82308468|sp|Q9YYU7|Q9YYU7_9HIVl,|82308466|sp|Q9YYU5|Q9YYU5_9HIVl,|82308464|sp|Q9YYU3|Q9YYU3_9HTVl,l82308429|sp|Q9YX74|Q9YX74_9fflVl,|82308427Ísp|Q9YX72|Q9YX72_9HIVl,|82308377|sp|Q9YVE8|Q9YVE8_9HIVl,|82308353|sp|Q9YV07|Q9YV07_9HIVl,|82308278|sp|Q9YPN8|Q9YPN8_9HIVl,|82308276|sp|Q9YPN6|Q9YPN6_9HIVl,|82308274|sp|Q9YPN4|Q9YPN4_9HIVl,|82308272|sp|Q9YPN2|Q9YPN2_9HIVlJ|82308270|sp|Q9YPN0|Q9YPN0_9HIVl,182308268|splQ9 YPM81 Q9YPM8_9HTV 1,|82308244|sp|Q9YP54|Q9YP54_9HTVl,|82308223|sp|Q9YNC0|Q9YNC0_9HIVl,

]S2311513 j5p|Q7SPP7iQ7SPP7_9HIVl s|82310792|sp]Q6X6X9|Q6X6X9_9HIVl,|82310775 |sp|Q6X6M5|Q6X6M5_9HIVl,|82310765|sp|Q6X6H5|Q6X6H5_9HIVl,|82310758|sp|Q6X4P9|Q6X4P9_9HTVl,|82310752)sp|Q6X4N3 |Q6X4N3_9HIV1,|82309888|sp|Q6PR10|Q6PR10_9fflVl,|82309833|sp|Q5MHl 1 |Q5MH11_9HIV1,|82309827|sp|Q5MGZ3|Q5MGZ3_9HTVl,|82309821|sp|Q5MGX5|Q5MGX5_9HIVl,182309815 |sp|Q5MGV8|Q5MGV8_9HIVl,|82309810|sp|Q5MGT6|Q5MGT6_9HTVl,|82309378|sp|Q5C9X3|Q5C9X3_9HTVl,j82308942|sp|0418811041881_9HIV1,|82308469|splQ9YYU8|Q9YYU8_9HTVl,|82308467|sp|Q9YYU6|Q9YYU6_9HIVl,|82308465|sp|Q9YYU4|Q9YYU4_9fflVl,|82308463|sp|Q9YYU2|Q9YYU2_9HIVl,|82308428 |sp|Q9YX73 |Q9YX73_9HIV1,|82308426|sp|Q9YX71|Q9YX71_9HIVl3|82308355|sp|Q9YV13|Q9YV13_9BQVl,182308351 |splQ9YUZ9|Q9YUZ9_9HIVl,|82308277|sp|Q9YPN7|Q9YPN7_9HrVl,|82308275|sp|Q9YPN5|Q9YPN5_9HTVl,|82308273|sp|Q9YPN3|Q9YPN3_9HIVl,|82308271|sp|Q9YPNl|Q9YPNl_9HTVl,|82308269|sp|Q9YPM9|Q9YPM9_9HIVl,|82308267|sp|Q9YPM7|Q9YPM7_9HIVl,|82308243|sp|Q9YP53|Q9YP53_9HIVl,|82308222|sp|Q9YNB9|Q9YNB9_9HTVl,|82308221|sp|Q9YNB8|Q9YNB8_9fflVl,|82308219|sp|Q9YNA3|Q9YNA3_9HIVl,|82307982|sp|Q9WSE3|Q9WSE3_9HIVl,|82307901 |sp|Q9 WQIl |Q9 WQI1_9HIV 1,|82307732|sp|Q9WM30|Q9WM30_9HIVl,l82307730|sp|Q9WM28|Q9WM28_9HIVl,|82307728|sp|Q9WM26|Q9WM26_9HIVl,|82307726|sp|Q9WM24|Q9WM24_9HIVl,|82307724|sp|Q9WM22|Q9WM22_9HIVl,|82307722|sp|Q9WM20|Q9WM20_9HIVl,|82307720|sp|Q9WM18|Q9WM18_9HIVl,|82307718|sp|Q9WM16|Q9WM16_9HIVl,|82307695|sp|Q9WLM6|Q9WLM6_9HIVl,|82307693|sp|Q9WLM4|Q9WLM4_9HIVl,|82307686|sp|Q9WLG9|Q9WLG9_9HIVl,|82307573|sp|Q9WK40|Q9WK40_9HIVl,|82307571|sp|Q9WK38|Q9WK38_9HIVl,|82307542|sp|Q9WIUl|Q9\VTUl_9HTV'l,|82307535|sp|Q9WIS2|Q9\VlS2_9rfJLVÍ,|82307274|sp|Q9WC61|Q9WC61_9HIVl,|82307113|sp|Q9QSUl|Q9QSUl_9HIVl,|82307109|sp|Q9QSS3|Q9QSS3_9HIVl,|82307105|sp|Q9QSQ6|Q9QSQ6_9HIVl,|82306524|sp|Q9QML5 |Q9QML5_9HIV1,|82306495|sp|Q9QM82|Q9QM82_9ffiVl,|82305927|sp|Q9Q6W8|Q9Q6W8_9HIVl,|82305922|sp|Q9Q6U9|Q9Q6U9_9HIVl,|82305 870|sp|Q9Q5H5|Q9Q5H5_9HIVl,

|82305868|sp|Q9Q5H3|Q9Q5H3_9HIVl, _____ ..... _

|82305866|sp|Q9Q5Hl|Q9Q5Hl_9HTVrl, |82305865|sp|Q9Q5H0|Q9Q5H0_9HIVl trancada,|82305864|sp|Q9Q5G9|Q9Q5G9_9HIVl trancada, |82305863|sp|Q9Q5G8|Q9Q5G8_9HTVl>|82305862|sp|Q9Q5G7|Q9Q5G7_9fflVl, -

|82308220|sp|Q9YNB7|Q9YNB7_9HTVl,|82307984|sp|Q9WSF2|Q9WSF2_9HTVl,|82307973|sp|Q9WS44|Q9WS44_9HrVl,|82307899|sp|Q9WQH3|Q9WQH3_9HIVl,|82307731 |sp|Q9WM29|Q9WM29_9HF/l,|82307729|sp|Q9WM27|Q9WM27_9HIVl,|82307727|sp|Q9 WM251Q9 WM25_9HTV 1,|82307725|sp|Q9WM23|Q9WM23_9fflVl,|82307723|sp|Q9WM21|Q9WM21_9HIVl,|82307721 |sp|Q9WM19|Q9WM19_9mVl,|82307719|sp|Q9WM17|Q9WM17_9fflVl,|82307696|sp|Q9WLM7|Q9WLM7_9HIVl,|82307694|sp|Q9WLM5|Q9WLM5_9HTVl,|82307687|sp|Q9WLH2|Q9WLH2_9HIVl3|82307574|sp|Q9WK41 |Q9WK41_9HIV1,|82307572|sp|Q9WK39|Q9WK39_9fflVl,|82307545|sp|Q9WJR3|Q9WJR3_9mVl,|82307539|sp|Q9WITl|Q9WITl_9HIVl,|82307276jsp|Q9\YC70|Q9\VC70_9HIVli|82307187|sp|Q9W9D3|Q9W9D3_9fflVl,|82307111 |sp|Q9QST2|Q9QST2_9HTVl,|82307107|sp|Q9QSR5|Q9QSR5_9HIVl,|82306567|sp|Q9QNX6|Q9QNX6_9HIVl,|82306522|sp|Q9QMK7|Q9QMK7_9HIVl,|82305929|sp|Q9Q6Y5|Q9Q6Y5_9HIVl,|8230^924|sp|Q9Q6V7|Q9Q6V7_9HTVl,|82305871|sp|Q9Q5H6|Q9Q5H6_9HnVl,|82305869|sp|Q9Q5H4|Q9Q5H4_9HIVl,|82305867|sp|Q9Q5H2|Q9Q5H2_9HTVl,

|82305860|sp|Q9Q5G5|Q9Q5G5_9HIVl,|82305858|sp|Q9Q5G3|Q9Q5G3_9HIVl,|82305856|sp|Q9Q5Gl|Q9Q5Gl_9fflVl,|82305854|sp|Q9Q5F9|Q9Q5F9_9HIVl,|82305852|sp|Q9Q5F7|Q9Q5F7_9HIVl,|82305850|sp|Q9Q5F5|Q9Q5F5_9HIVl trancada,|82305849|sp|Q9Q5F4|Q9Q5F4_9HIVl trancada,

|82305848|sp|Q9Q5F3|Q9Q5F3_9HIVl trancada,

|82305846|sp|Q9Q5Fl|Q9Q5Fl_9HIVl,

|82305844|sp|Q9Q5E9|Q9Q5E9_9HTVl,

|82305842|sp|Q9Q5E7|Q9Q5E7_9fflVl,

|82305840|sp|Q9Q5E5|Q9Q5E5_9HIVl5

|82305838|sp|Q9Q5E3|Q9Q5E3_9MVl,

|82305836|sp|Q9Q5El|Q9Q5El_9HIVl,

182305834|sp|Q9Q5D9|Q9Q5D9_9fflVl,

|82305832|sp|Q9Q5D7|Q9Q5D7_9HIVl,

|82305861|sp|Q9Q5G6|Q9Q5G6_9HTVl,|82305859|sp|Q9Q5G4|Q9Q5G4_9HIVl,|82305857|sp|Q9Q5G2|Q9Q5G2_9HIVl,|82305855|sp|Q9Q5G0|Q9Q5G0_9fflVl,|82305853|sp|Q9Q5F8|Q9Q5F8_9HIVl,|82305851|sp|Q9Q5F6|Q9Q5F6_9HIVl

|82305847|sp|Q9Q5F2|Q9Q5F2_9HTVl,|82305845|sp|Q9Q5F0|Q9Q5F0_9fflVl,|82305843|sp|Q9Q5E8|Q9Q5E8_9mVl,|82305841 |sp|Q9Q5E6|Q9Q5E6_9HIVl,|82305839|sp|Q9Q5E4|Q9Q5E4_9HIVl,|82305837|sp|Q9Q5E2|Q9Q5E2_9HIVl,|82305835|sp|Q9Q5E0|Q9Q5E0_9HIVl,|82305833 |sp|Q9Q5D8|Q9Q5D8_9HIVl)|8230583 l|sp|Q9Q5D6|Q9Q5D6_9HIYl}|82305830|sp|Q9Q5D5|Q9Q5D5_9HIVl, |82305829|sp|Q9Q5D4|Q9Q5D4_9HIVlt™ncada'

|82305828|sp|Q9Q5D3|Q9Q5D3_9HIVl,|82305826|sp|Q9Q5Dl|Q9Q5Dl_9mVl,|82305824|sp|Q9Q5C9|Q9Q5C9_9HIVl,|82305822|8ρ|(29ζ)507|(29(3507_9Ηΐνΐ,|82305820|sp|Q9Q5C5|Q9Q5C5_9fflVl,|82305818|sp|Q9Q5C3|Q9Q5C3_9HIVl,|82305816|sp|Q9Q5Cl|Q9Q5Cl_9HTVl,|82305814|sp|Q9Q5B9|Q9Q5B9_9HTVl,182305812jsp |Q9Q5B7 |Q9Q5B7_9HIV 1,|82305810|sp|Q9Q5B4|Q9Q5B4_9HTVl,|82305808|sp|Q9Q5B0|Q9Q5B0_9HIVl,|82305806|sp|Q9Q5A8|Q9Q5A8_9HTVl,|82305804|sp|Q9Q5A6|Q9Q5A6_9HIVl,|82305802|sp|Q9Q5A4|Q9Q5A4_9HIVl,|82305800|sp|Q9Q5A2|Q9Q5A2_9fflVl,|82305798|sp|Q9Q5A0|Q9Q5A0_9HTVl,|82305796|spjQ9Q598|Q9Q598_9fflyi,|82305794|sp|Q9Q596jQ9Q59õ_9HívÍ,|82305792|sp|Q9Q594|Q9Q594_9fflVl,|82305564|sp]Q9PX20|Q9PX20_9HTVl trancada

|82305563|sp|Q9PXll|Q9PXll_9HIVltnmcada,

|82305401 |sp|Q9JAC0|Q9JAC0_9HIVl,|82305060|sp|Q9IV96|Q9rV96_9HrVl,|82305056|sp|Q9IVl 1|Q9IV11_9HIV1,|82304827|sp|Q9IH72|Q9ffl72_9HIVl,|82304825 |sp|Q9IH68|Q9IH68_9fflVl,|82304823|sp|Q9IH66|Q9IH66_9HIVl,|82304821 |sp|Q9IH64|Q9IH64_9HrVl,|82304699|sp|Q9ID88|Q9ID88_9HIVl,|823036461sp|Q9DRXl|Q9DRXl_9fflVl,|82303644|sp|Q9DRW9|Q9DRW9_9HIVl,|82303642|sp|Q9DRW7|Q9DRW7_9HIVl,182303640|sp |Q9DRW51 Q9DRW5_9HIV 1,|82303638|sp|Q9DRW3|Q9DRW3_9HIVl,|82303636|sp|Q9DRWl|Q9DRWl_9HIVl,|82303634|sp|Q9DRV9|Q9DRV9_9HIVl,|82303632|sp|Q9DRV7|Q9DRV7_9HIVl,|82303630|sp|Q9DRV5|Q9DRV5_9HIVl,|82303628|sp|Q9DRV3|Q9DRV3_9HIVl,|82303626|sp|Q9DRVl|Q9DRVl_9HIVl,j82303624|sp |Q9DRU9|Q9DRU9_9HIV 1,|82303622|sp|Q9DRU7|Q9DRU7_9HIVl,|82303620|sp|Q9DRU5|Q9DRU5_9fflVl,

|82303618|sp|Q9DRUl|Q9DRUl_9fflVltruiicada,

|82303617|sp|Q9DRU0|Q9DRU0_9HIVl,|82303615|sp |Q9DRT8 |Q9DRT8_9HIV 1,|82303613|sp|Q9DRT6|Q9DRT6_9HIVl,

|82305827|sp|Q9Q5D2|Q9Q5D2_9HIVl,|82305825|sp|Q9Q5D0|Q9Q5D0_9HTVl,|82305823|sp|Q9Q5C8|Q9Q5C8_9HIVl,|82305821|sp|Q9Q5C6|Q9Q5C6_9HIVl,|82305819|sp|Q9Q5C4|Q9Q5C4_9HIVl,|82305817|sp|Q9Q5C2|Q9Q5C2_9HIVl,|82305815|sp|Q9Q5C0|Q9Q5C0_9HIVl,|82305813|sp|Q9Q5B8|Q9Q5B8_9HIVl,|82305811|sp|Q9Q5B6|Q9Q5B6_9HIVl,|82305809|sp|Q9Q5Bl|Q9Q5Bl_9HTVl,|82305807|sp|Q9Q5A9|Q9Q5A9_9fflVl,|82305805|sp|Q9Q5A7|Q9Q5A7_9MVl,|82305803|sp|Q9Q5A5|Q9Q5A5_9HTVl,|82305801 |sp|Q9Q5A3|Q9Q5A3_9HIVl,|82305799|sp|Q9Q5Al|Q9Q5Al_9HTVl,|82305797|sp|Q9Q599|Q9Q599_9fflVl,|82305795|sp|Q9Q597|Q9Q597_9HTVl,|82305793|3ρ|ρ9ρ595|ρ9ρ595_9Ηΐνΐ,|82305571|sp|Q9PX72|Q9PX72_9HTVl,

|82305553|sp|Q9PWX8|Q9PWX8_9HIVl>|82305096|sp|Q9IW45|Q9IW45_9HIVl,|82305058|sp|Q9IV87|Q9IV87_9HrVl,|82304828|sp|Q9IH73|Q9ffl73_9HIVl mutante,|82304826|sp|Q91H71|Q9IH71_9fflVl,|82304824|sp|Q9IH67|Q9IH67_9HIVl,|82304822|sp|Q9M65|Q9IH65_9HIVl,|82304701|sp|Q9ID97|Q9ID97_9HTVl,|82304154|sp|Q9E2H7|Q9E2H7_9HIVl,|82303645|sp|Q9DRX0|Q9DRX0_9fflVl,|82303643|sp|Q9DRW8|Q9DRW8_9HIVl,|82303641 |sp|Q9DRW6|Q9DRW6_9HIVl,|82303639|sp|Q9DRW4|Q9DRW4_9HIVlJ|82303637|sp|Q9DRW2|Q9DRW2_9HIVl,|82303635|sp|Q9DRW0|Q9DRW0_9HIVls|82303633|sp|Q9DRV8|Q9DRV8_9HIVl,|82303631|sp|Q9DRV6|Q9DRV6_9HIVl,|82303629|sp|Q9DRV4|Q9DRV4_9HIVl,|82303627|sp|Q9DRV2|Q9DRV2_9BQYl,|82303625|sp|Q9DRV0|Q9DRV0_9HIVl,182303623 |sp|Q9DRU8 |Q9DRU8_9HIV 1,|82303621 |sp|Q9DRU6|Q9DRU6_9HIVl,|82303619|sp|Q9DRU2|Q9DRU2_9HTVl,

|82303616|sp|Q9DRT9|Q9DRT9_9HIVl,|82303614|sp|Q9DRT7|Q9DRT7_9HIVl,|82303612|sp|Q9DRT5|Q9DRT5_9HTVl,|82303611 |sp|Q9DRT4|Q9DRT4_9HTVHrmKada,|82303609|sp|Q9DRT2|Q9DRT2_9HIVltnincada,|82303607|sp|Q9DRTO|Q9DRTO_9HIVl3j82303605 jsp |Q9DRS 8 |Q9DRS 89HIV1 trancada,

|82303604|sp|Q9DRS7|Q9DRS7_9HIVltraiicada,|82303603|sp|Q9DRS6|Q9DRS6_9HIVl trancada,|82303601 |sp|Q9DRS3|Q9DRS3_9HIVl,|82303599|sp|Q9DRSl|Q9DRSl_9HIVl,|82303597|spjQ9DRR5|Q9DRR5_9HIVl trancada,|82303596|sp|Q9DRR4|Q9DRR4_9HIVl tramada,|82303595|sp|Q9DRR3|Q9DRR3_9HIVl trancada,|82303593|sp|Q9DRRl|Q9DRRl_9HIVl,|82303591 |sp|Q9DRQ9|Q9DRQ9_9HIVl,|82303589|sp|Q9DRQ7|Q9DRQ7_9HIVl,|82303587|sp|Q9DRQ5|Q9DRQ5_9HIVl,|82303585|sp|Q9DRQ3|Q9DRQ3_9HIVl,|82303583]sp|Q9DRQl|Q9DRQl_9HIVl,|82303581|spjQ9DRP8jQ9pRP8_9HIVl,|82303579|sp|Q9DRP6jQ9DRP6_9HrvÍ,|82303577|sp|Q9DRP4|Q9DRP4_9HIVlJ|82303575|sp|Q9DRPl|Q9DRPl_9HIVl trancada,|82303573|sp|Q9DRN9|Q9DRN9_9HIVltr,incada»182303 5721sp|Q9DRN8 j Q9DRN8_9HTV 1,|82303570|sp|Q9DRN6|Q9DRN6_9HIVl)|82303325|sp|Q9DQ25|Q9DQ25_9HIVl,|82303318|sp|Q9DQ09|Q9DQ09_9HIVl,

|82303610|sp |Q9DRT31 Q9DRT3_9HIV 1,|82303608|sp|Q9DRTl|Q9DRTl_9HIVl,|82303606|sp|Q9DRS9|Q9DRS9_9HTVl,

|82303602|sp|Q9DRS4|Q9DRS4_9HTVl,|82303600|sp|Q9DRS2|Q9DRS2_9HIVl,|82303598|sp|Q9DRR9|Q9DRR9_9HIVl,

|82303594|sp|Q9DRR2|Q9DRR2_9HIVl,|82303592|sp|Q9DRR0|Q9DRR0_9HIVl,|82303590|sp|Q9DRQ8|Q9DRQ8_9HIVl,|82303588|sp|Q9DRQ6|Q9DRQ6_9fflVl,|82303586|sp|Q9DRQ4|Q9DRQ4_9HIVl,|82303584|sp|Q9DRQ2|Q9DRQ2_9HIVl,|82303582|sp|Q9DRP9|Q9DRP9_9HTVl,|82303580|sp|Q9DRP7|Q9DRP7_9HrVl,i82303578|sp|Q9DRP5!Q9DRP5_9HTVL|82303576|sp|Q9DRP3|Q9DRP3_9HTVl,|82303574|sp|Q9DRP0|Q9DRP0_9ffiVl,

|82303571|sp|Q9DRN7|Q9DRN7_9HIVl,|82303569|sp|Q9DRN5|Q9DRISÍ5_9HIVl,|82303320|sp|Q9DQ16|Q9DQ16_9HTVl,|82303317|sp|Q9DQ02|Q9DQ02_9HIVl,

1823033161sp|Q9DPZ7|Q9DPZ7_9HIV 1, |82303158|sp|Q9DHB8|Q9DHB8_9HIVltruiicada

|82303154|sp|Q9DH 15 |Q9DH 15_9HIV 1,

|82303150|sp|Q9DGUl|Q9DGUl_9mVl,

|82302372|sp|Q998H0|Q998H0_9HrVl,

|82302361 |sp|Q994Q5|Q994Q5_9HIVl,

|82302357|sp|Q994N7|Q994N7_9HIVl,

|82302352|sp|Q994L0]Q994L0_9HIVl,

|82302348jsp |Q994J2|Q994J2_9HIV 1,

|82302344|sp|Q994H4|Q994H4_9HIVl,

|82302340|sp|Q994F6|Q994F6_9HIVl,

|82301355|sp|Q90VH|Q90VIl_9HIVl,

|82301351|sp|Q90VH5|Q90VH5_9HIVl,

|82301345 |sp|Q90VF9|Q90VF9_9HIVl,

|82301338|sp|Q90VE8|Q90YE8_9HIVl,

|82300720|sp|Q90QQ4|Q90QQ4_9HIVl,

|82300716|sp|Q90QN9|Q90QN9_9HTVl,

|82300714|sp|Q90QNl|Q90QNl_9HTVrl,

|82300712|sp|Q90QM5|Q90QM5_9HIVl,

|823006301sp|Q90M16|Q90M16_9HIVl,

|82300557|sp|Q90DZ6|Q90DZ6_9HIVl,

|82300509|sp|Q90D23|Q90D23_9HIVl,

|82300505|sp|Q90D05|Q90D05_9HIVl,

|82303152|sp|Q9DGX7|Q9DGX7_9fflVl,|82303145|sp|Q9DGR9|Q9DGR9_9HTVl,|82302363|sp|Q994R4|Q994R4_9HTVl,|82302359|sp|Q994P6|Q994P6_9HTVl,|82302355|sp|Q994M8|Q994M8_9HrVl,|82302350|sp|Q994Kl|Q994Kl_9HTVl,|82302346|sp|Q994D|Q994I3_9HIVl,|82302342|sp|Q994G5|Q994G5_9HIVl,|82301451|sp|Q90VU7|Q90VU7_9HTVl,|82301353|sp|Q90VH8|Q90VH8_9HIVl)|82301348|sp|Q90VG9|Q90VG9_9HIVl,|82301343 |sp|Q90 VF6|Q90VF6_9HIV 1,|82301336|sp|Q90VE5|Q90VE5_9HTVl3|82300718|sp|Q90QP6|Q90QP6_9HIVl,|82300715|sp|Q90QN4|Q90QN4_9fflVl,|82300713|sp|Q90QM6|Q90QM6_9HTVl,|82300708|sp|Q90QJ5|Q90QJ5_9HTVl,|82300629|sp|Q90M15|Q90M15_9HIVl,|82300515 |sp|Q90DU0|Q90DU0_9HIVl,|82300507|sp|Q90D14|Q90D14_9HIVlJ|82300503|sp|Q90CZ6|Q90CZ6_9HIVl,182300501 |sp|Q90CY7|Q90CY7_9HIVl,|82300497|sp|Q90CX0|Q90CX0_9HIVl,j82300493|sp|Q90CV2|Q90CV2_9HrVl,|82299666|sp|Q903T9|Q903T9_9Hm trancada|82299629|sp|Q902T2|Q902T2_9HIVl,|82299625|sp|Q902R4|Q902R4_9HIVl,|82299621|sp|Q902P6|Q902P6_9HIVl,|82299617|sp|Q902M3|Q902M3_9HIVl,|82299613|sp|Q902K4|Q902K4_9HIVl3|82299608|sp|Q902I3 |Q902I3_9HIV 1,|82299604|sp|Q902G5|Q902G5_9fflVl,|82299538|sp|Q901Y0|Q901Y0_9fflVl,|82299534|sp|Q901W2|Q901W2_9HIVl,|82299507|sp|Q900Y4|Q900Y4_9HIVl,|82299181 |sp|Q8USP6|Q8USP6_9HIVl,|82299179|sp|Q8USP4|Q8USP4_9HIVl,|82299177|sp|Q8USP2]Q8USP2_9HIVl,|82299175|sp|Q8USP0|Q8USP0_9HIVl,]82299173]sp|Q8USN8!Q8USN8 9HTV1,182299171 ísp|Q8USN6ÍQ8USN6l9HIVl!|82299169|sp|Q8USN4|Q8USN4_9fflVl,|82299167|sp|Q8USN2|Q8USN2_9HIVl,|82299165|sp|Q8USN0|Q8USN0_9HIVl,|82299163|sp|Q8USM8|Q8USM8_9HIVl,|82299161|sp|Q8USM6|Q8USM6_9HIVl,|82299159|sp|Q8USM3 |Q8USM3_9HIV1,|82299157|sp|Q8USM0|Q8USM0_9HIVltrunca«Ia,|82299155|sp|Q8USL7|Q8USL7_9HIVl,|82299153 |sp|Q8USL4|Q8USL4_9HTVl,|8229915 l|sp|Q8USL2|Q8USL2_9HIVl,|82299148|sp|Q8USK9|Q8USK9_9HIVl,|82299146|sp|Q8USK6|Q8USK6_9HIVl,|82299143|sp|Q8USK3 |Q8USK3_9HIV1;|82299141|sp|Q8USJ9|Q8USJ9_9HIVl,|82299139|sp|Q8USJ7|Q8USJ7_9HIVl,|82299137|sp|Q8USJ5|Q8USJ5_9HIVl,|82299135|sp|Q8US J3 |Q8US J3_9HIV1,|82299133|sp|Q8USJ0|Q8USJ0_9HIVl,|82299131|sp|Q8USI8|Q8USI8_9HIVl,|82299129|sp|Q8USI6|Q8USI6_9HIVl,|82299127|sp|Q8USI4|Q8USI4_9HIVl,|82299125|sp|Q8USI2|Q8USI2_9HrVl5|82299123|sp|Q8USI0|Q8USI0_9mvl,|82299121|sp|Q8USH8|Q8USH8_9HIVl,182299119|sp|Q8USH6|Q8USH6_9HIVl,|82299073|sp|Q8UPQ4|Q8UPQ4_9HIVl,|82299069|sp|Q8UPN7|Q8UPN7_9fflVl,j82299065|sp|Q8UPM0 |Q8UPM0_9HIV 1,

i82300499|sp|Q90CX8|Q90CX8_9mVl,|82300495|sp|Q90CWl|Q90CWl_9HrVl,|82300491|sp|Q90CK5|Q90CK5_9HIVl,|82299631 |sp|Q902Ul |Q902U1_9HIV1,|82299627|sp|Q902S3|Q902S3_9HIVl,|82299623|sp|Q902Q5|Q902Q5_9fflVl,|82299619jsp|Q902N7|Q902N7_9HIVl,|82299615|sp|Q902L3|Q902L3_9HIVl,|82299610|sp|Q902J2|Q902J2_9HTVl,|82299606|sp|Q902H4|Q902H4_9HIVl,|82299540|sp|Q901Y9|Q901Y9_9HrVl,|82299536|sp|Q901Xl |Q901X1_9HIV1,|82299510|sp|Q900Z3|Q900Z3_9Hiyi,|82299437|sp IQ900A5 |Q900A5_9HIV 1 trancada,|82299180|sp|Q8USP5|Q8USP5_9HIVl5j82299178|sp|Q8USP3ÍQ8USP3_9HIVl,|82299176|sp|Q8USP 1 |Q8USP 1_9HIV1,|82299174|sp|Q8USN9|Q8USN9_9HrVl,[82299172!sp|Q8USN7jQ8USN7_9HIVl;|82299170ÍspÍQ8USN5ÍQ8USN5_9HIVl^|82299168|sp|Q8USN3|Q8USN3_9HrVl,|82299166|sp|Q8USNl|Q8USNl_9HIVl5j82299164|sp|Q8USM9|Q8USM9_9HTVl,|82299162|sp|Q8USM7|Q8USM7_9HIVl,|82299160|sp|Q8USM5|Q8USM5_9HrVl,|82299158 jsp |Q8USM 1 |Q8USM 1_9HTV 1,|82299156|sp|Q8USL9|Q8USL9_9HIVl,|82299154|sp]Q8USL5|Q8USL5_9HIVl,|82299152|sp|Q8USL3|Q8USL3_9HTVl,|82299149|sp|Q8USL0|Q8USL0_9HIVl,|82299147|sp|Q8USK8|Q8USK8_9HIVl,|82299145|sp IQ8USK5 |Q8USK5_9HIV 1,|82299142|sp|Q8USK2|Q8USK2_9HrVl,|82299140|sp |Q8US J8 |Q8US J8_9HIV 1,|8229913 81sp |Q8US J6|Q8US J6_9HIV 1,|82299136|sp|Q8USJ4|Q8USJ4_9HIVl,|82299134|sp|Q8USJl|Q8USJl_9HrVl,|82299132|sp|Q8USI9|Q8USI9_9HIVl,|82299130|sp|Q8USI7|Q8USI7_9HIVl,|82299128|sp|Q8USI5|Q8USI5_9HIVl,|82299126|sp|Q8USI3 |Q8USI3_9HIV1,|82299124|sp|Q8USIl|Q8USIl_9HrVl,|82299122|sp|Q8USH9|Q8USH9_9HIVl,|82299120|sp|Q8USH7|Q8USH7_9HTVl,|82299118|sp|Q8USH5|Q8USH5_9HIVl,182299071 |sp|Q8UPP6|Q8UPP6_9HIVl,|82299067|sp|Q8UPM9|Q8UPM9_9HIVl,|82299063|sp|Q8UPLl |Q8UPL1_9HTV 1,82299057|sp|Q8UNL8|Q8UNL8_9HIVl,

82299053|sp|Q8UlSIK0 |Q8UNK0_9HIV 1,

82298936|sp|Q8UMG0|Q8UMG0_9HIVl,

82298901 |sp|Q8UM91 |Q8UM91_9HIV15

82298898|sp|Q8UM86|Q8UM86_9HrVl,

82298867|sp|Q8QFK8|Q8QFK8_9HIVl,

82298821 |sp|Q8QDF4|Q8QDF4_9HIVl,

82298539|sp|Q8Q662|Q8Q662_9HIVl,

82298537|sp|Q8Q660|Q8Q660_9HIVl,

82298535|sp|Q8Q658|Q8Q658_9HIVl,

82298533|sp|Q8Q656|Q8Q656_9HIVl,

8229853 l|sp|Q8Q654|Q8Q654_9HIVl,

82298529|sp|Q8Q652|Q8Q652_9HIVl,

82298527|sp|Q8Q650|Q8Q650_9HIVl,

82298525|sp|Q8Q648|Q8Q648_9HIVl,

82298523|sp|Q8Q646|Q8Q646_9HIVl,

82298521 |sp|Q8Q644|Q8Q644_9HIVl,

82298519jspjQ8Q642jQ8Q642_9HIVl,

82298517jspjQ8Q640iQ8Qó40_9HTvÍ,

82298515|sp|Q8Q638|Q8Q638_9HIVl,

82298513|sp|Q8Q636|Q8Q636_9HIVl,

822985 ll|sp|Q8Q634|Q8Q634_9HrVl3

82298509|sp|Q8Q632|Q8Q632_9HIVl,

82298507|sp|Q8Q630|Q8Q630_9HIVl,

82298505|sp|Q8Q628|Q8Q628_9HIVl,

82298503Jsp|Q8Q626|Q8Q626_9HIVl,

82298501 |sp|Q8Q623|Q8Q623_9HIVl,

82298499|sp|Q8Q621|Q8Q621_9HIVl,

82298497|sp|Q8Q619|Q8Q619_9HTVl,

82298495|sp|Q8Q616|Q8Q616_9HIVl,

82298493|sp|Q8Q614|Q8Q614_9HrVl,

82298491 |sp|Q8Q611 |Q8Q611_9HIV1,

82298489|sp|Q8Q609|Q8Q609_9HrVl,

82298487|sp|Q8Q606|Q8Q606_9HIVl,

82298485|sp|Q8Q604|Q8Q604_9HIVl,

82298483 |sp|Q8Q602|Q8Q602_9HIVl,

8229848 l|sp|Q8Q600|Q8Q600_9HIVl,

82298479|sp|Q8Q5Z8|Q8Q5Z8_9mVl3

82298477|sp|Q8Q5Z6|Q8Q5Z6_9HTVl,

82298475 |sp|Q8Q5Z4|Q8Q5Z4_9HIVl3

82298473 |5ρ|ρ8ρ5Ζ2|ρ8ρ5Ζ2_9ΗΓνΐ3

82298471 |sp|Q8Q5Z0|Q8Q5Z0_9mVl)

82298469|sp|Q8Q5Y8]Q8Q5Y8_9HIVl,

82298467|sp|Q8Q5Y5|Q8Q5Y5_9HIVl,

82298465 |sp|Q8Q5Y3|Q8Q5Y3_9HrVl,

82298463 |sp|Q8Q5 Yl |Q8Q5 Y1_9HIV1,

8229846 l|sp|Q8Q5X9|Q8Q5X9_9HIVl,

82298459|sp|Q8Q5X7|Q8Q5X7_9HIVl,

182299055|sp|Q8UNK9|Q8UNK9_9HIV 1|82298938|sp|Q8UMG9|Q8UMG9_9HIVl|82298932|sp|Q8UMD3|Q8UMD3_9HIVl|82298900|sp]Q8UM89|Q8UM89_9HIVl|82298897|sp|Q8UM85|Q8UM85_9HIVl|82298866|sp|Q8QFK6|Q8QFK6_9HTVl|82298620|sp|Q8Q7Y9|Q8Q7Y9_9HTVl|82298538|sp|Q8Q661 |Q8Q661_9HTV1|82298536|sp|Q8Q659|Q8Q659_9HIVl|82298534|sp|Q8Q657|Q8Q657_9HIVl|82298532|sp|Q8Q655|Q8Q655_9HIVl|82298530|sp|Q8Q653|Q8Q653_9HIVl|82298528|sp]Q8Q651 |Q8Q651_9HTV1|82298526|sp|Q8Q649|Q8Q649_9fflVl|82298524|sp|Q8Q647|Q8Q647_9HIVl|82298522jsp|Q8Q645|Q8Q645_9fflVl|82298520|sp|Q8Q643|Q8Q643_9HIVl|82298518|sp|Q8Q641|Q8Q641_9HIVliS2298516|sp|Q8Q639|Q8Q639_9Hr/l182298514|sp|Q8Q637|Q8Q637_9HIVl|82298512|sp|Q8Q635|Q8Q635_9HXVl|82298510|sp|Q8Q633 |Q8Q633_9HIV1|82298508 |sp|Q8Q631 |Q8Q631_9HIV1|82298506|sp|Q8Q629|Q8Q629_9HIVl|82298504|sp|Q8Q627|Q8Q627_9HIVl|82298502|sp|Q8Q625jQ8Q625_9HIVl|82298500|sp|Q8Q622|Q8Q622_9HrVl|82298498|sp|Q8Q620|Q8Q620_9HIVl|82298496|sp|Q8Q618|Q8Q618_9HIVl|82298494|sp|Q8Q615|Q8Q615_9mVl|82298492|sp|Q8Q613 |Q8Q613_9HTV1|82298490|sp|Q8Q610|Q8Q610_9HIVl|82298488|sp|Q8Q608|Q8Q608_9HTVl|82298486|sp|Q8Q605|Q8Q605_9HIVl|82298484|sp|Q8Q603|Q8Q603_9HIVl|82298482|sp|Q8Q601|Q8Q601_9HIVl|82298480|sp|Q8Q5Z9|Q8Q5Z9_9HTVl|82298478|sp|Q8Q5Z7|Q8Q5Z7_9HIVl|82298476|sp|Q8Q5Z5|Q8Q5Z5_9HTVl|82298474|sp|Q8Q5Z3|Q8Q5Z3_9HIVl|82298472|sp|Q8Q5Zl |Q8Q5Z1_9HIV1|82298470|sp|Q8Q5Y9|Q8Q5Y9_9fflVl|82298468|sp|Q8Q5Y7|Q8Q5Y7_9HIVl|82298466|sp|Q8Q5Y4|Q8Q5Y4_9HIVl|82298464|sp|Q8Q5Y2|Q8Q5Y2_9HIVl|82298462|sp|Q8Q5Y0|Q8Q5Y0_9HTVl|82298460|sp|Q8Q5X8|Q8Q5X8_9HIVl|82298458|sp|Q8Q5X6|Q8Q5X6_9HIVl82298457|sp|Q8Q5X5|Q8Q5X5_9EQYl,

82298123jsp|Q8Q0Y3|Q8Q0Y3_9HIVl,

82297857|sp|Q8JC70|Q8JC70_9HIVl,

82297853|sp|Q8JC52|Q8JC52_9HTVl,

82297849|sp|Q8JC34|Q8JC34_9MVl,

82297845|sp|Q8JC16|Q8JC16_9HIVl,

82297841 )sp|Q8 JC03 |Q8 JC03_9HIV 1,

82297837|spÍQ8JBY5|Q8JBY5_9HTVl,

82297833jsp|Q8JBW7|Q8JBW7_9HIVl,

82297829|sp|Q8JBU9|Q8JBU9_9mVl,

82297825|sp|Q8JBTl|Q8JBTl_9HIVl,

82297821|sp|Q8JBR3|Q8JBR3_9HIVl,

82297817|sp|Q8 JBP5 |Q8 JBP5_9HIV 1,

8229781 ljsp|Q8JBM4|Q8JBM4_9HIVl,

82297807|sp|Q8JBK6|Q8JBK6_9HIVl,

82297803|sp|Q8JBI8|Q8JBI8_9HIVl,

82297799|sp|Q8JBH0|Q8JBH0_9HIVl,

82297795|sp|Q8JBF2|Q8JBF2_9HIVl5

82297791 |sp|Q8JBD4|Q8 JBD4_9HIV1,

82297787|sp|Q8JBB6|Q8JBB6_9HIVl,

82297782|sp|Q8JAX5|Q8JAX5_9HIVl,

82297584|sp|Q8J9B7|Q8J9B7_9HIVl,

82297363|sp|Q8J6B9|Q8J6B9_9HIVl,

82297361 |sp|Q8J6B7|Q8J6B7_9HIVl,

82297359|sp|Q8J6B5|Q8J6B5_9HrVl,

82297357|sp|Q8J6B3 |Q8J6B3_9HIV 1,

82297355|sp|Q8J6Bl|Q8J6Bl_9HrVl,

82297353|sp|Q8J6A9|Q8J6A9_9HIVl,

82297106|sp|Q8J580|Q8J580_9HIVl,

82297104|sp|Q8J578|Q8J578_9HIVls

82297102|sp|Q8J576|Q8J576_9fflVl,

82297100|sp|Q8J574|Q8J574_9HIVl,

82297098|sp|Q8J572|Q8J572_9fflVl5

82297096|sp]Q8J570|Q8J570_9HIVl,

82297094|sp|Q8J568|Q8J568_9HIVl5

82297092|sp|Q8J566|Q8J566_9HIVl,

82297090|sp|Q8J564|Q8J564_9fflVl,

82297088|sp|Q8J562|Q8J562_9HIVl,

82297086|sp|Q8J560|Q8J560_9HIVl,

82296965|sp|Q8J3U2|Q8J3U2_9HIVl3

82296963|sp|Q8J3M8|Q8J3M8_9HIVl,

82296961 |sp|Q8 J3M6|Q8 J3M6_9HIV1,

82296959|sp|Q8J3M4|Q8J3M4_9mVl,

82296957|sp|Q8J3M2|Q8J3M2_9HrVl,

82296955|sp|Q8J3M0|Q8J3M0_9HrVl,

82296953|sp|Q8J3L8|Q8J3L8_9HIVl,

82296951 |sp|Q8 J3L6|Q8 J3L6_9HTV1,

82296949|sp|Q8J3L4|Q8J3L4_9HIVl,

|82298456|sp|Q8Q5X4|Q8Q5X4_9HTVl|82298093|sp|Q8JEL6|Q8JEL6_9HIVl|82297855|sp|Q8JC61|Q8JC61_9HIVl|8229785 l|sp|Q8JC43|Q8JC43_9HIVl|82297847|sp|Q8JC25|Q8JC25_9HIVl|82297843|sp|Q8JC07(Q8JC07_9HIVl|82297839|sp|Q8JBZ4|Q8JBZ4_9HTVl|82297835|sp|Q8JBX6|Q8JBX6_9HIVl|82297831|sp|Q8JBV8|Q8JBV8_9HIVl|82297827|sp|Q8JBU0|Q8JBU0_9HIVl|82297823|sp|Q8JBS2|Q8JBS2_9HIVl]82297819|sp|Q8JBQ4|Q8JBQ4_9HIVl|82297814|sp|Q8JBN5lQ8JBN5_9HTVl|82297809|sp|Q8JBL5 |Q8 JBL5_9HTV 1|82297805|sp|Q8JBJ7]Q8JBJ7_9HIVl|82297801 |sp|Q8JBH9|Q8JBH9_9HIYl|82297797|sp|Q8JBGl|Q8JBGl_9HIVl|82297793|sp|Q8JBE3|Q8JBE3_9Hiyi|82297789ÍspjQ8IBC5jQ8JBC5_9Hrvi|82297785|sp|Q8JBA7|Q8JBA7_9HIVl|82297780|sp|Q8JAW7|Q8JAW7_9HTVl1822975 82|sp|Q8 J9 A8 |Q8 J9 A89HIV1|82297362|sp|Q8J6B8|Q8J6B8_9HIVl|82297360|sp|Q8J6B6|Q8J6B6_9HIVl18229735 8|sp|Q8J6B4|Q8J6B4_9HIVl|82297356|sp|Q8J6B2|Q8J6B2_9HIVl|82297354|sp|Q8J6B0|Q8J6B0_9HIVl|82297352|sp|Q8J6A8|Q8J6A8_9HTVl|82297105|sp|Q8J579|Q8J579_9HIVl|82297103|sp|Q8J577|Q8J577_9HIVl|82297101|sp|Q8J575|Q8J575_9mVl|82297099|sp|Q8J573|Q8J573_9mVl|82297097|sp|Q8J571|Q8J571_9HIVl|82297095|sp|Q8J569|Q8J569_9HIVl|82297093|sp|Q8J567|Q8J567_9HQVl|82297091|sp|Q8J565|Q8J565_9HIVl|82297089|sp|Q8J563|Q8J563_9HIVl|82297087|sp|Q8J561|Q8J561_9HIVl|82297085|sp|Q8J559|Q8J559_9HIVl|82296964|sp|Q8J3M9|Q8J3M9_9HIVl|82296962|sp|Q8J3M7|Q8J3M7_9HIVl|82296960|sp|Q8J3M5|Q8J3M5_9HIVl|82296958|sp|Q8J3M3|Q8J3M3_9HIVl|82296956|sp|Q8J3Ml|Q8J3Ml_9HIVl|82296954|sp|Q8J3L9|Q8J3L9_9HIVl|82296952|sp|Q8J3L7|Q8J3L7_9HIVlj82296950|sp|Q8J3L5|Q8J3L5_9HIVl|82296948|sp|Q8J3L3|Q8J3L3_9HIVl|82296947|sp|Q8J3L2|Q8J3L2_9fflVl,

|82296945|sp|Q8J3L0|Q8J3L0_9fflVl,

|82296943|sp|Q8J3K8|Q8J3K8_9fflVl,

|82296829|sp|Q8J312|Q8J312_9HIVl,

|82296827|sp|Q8AUH8|Q8AUH8_9mVl,

|82296799|sp|Q8AU76|Q8AU76_9HrVl,

|82296795|sp|Q8AU58|Q8AU58_9HIVl,

|82296793|sp|Q8AU55|Q8AU55_9fflVl,

|82296791 |sp|Q8AU53 |Q8AU53_9HIV1,

|82296789|sp|Q8AU51 |Q8 AU5 1_9HIV1,

|82296787|sp|Q8AU49|Q8AU49_9HIVl5

|82296785|sp|Q8AU47|Q8AU47_9HIVl,

|82296783|sp|Q8AU45|Q8AU45_9mVl5

|82296781 |sp|Q8AU43 |Q8 AU43_9HIV1,

|82296779|sp|Q8AU41 |Q8 AU41_9HIV1,

|82296777|sp|Q8AU39|Q8AU39_9HrVl,

|82296775|sp|Q8AU37|Q8AU37_9HTVl,

182296773 |sp|Q8AU35 |Q8AU35_9HIV1,

ICOOO^TI ΔτττϊΐηδΛττιι atmn

|82296769|sp|Q8AU31 |Q8AU31_9HIV1,

|82296767|sp|Q8AU29|Q8AU29_9HIVl,

|82296765|sp|Q8AU27|Q8AU27_9HIVl,

|82296732|sp|Q8ATN7|Q8ATN7_9HIVl,

|82296655|sp|Q8AQV6|Q8AQV6_9HrVl,

|82296651 |sp|Q8AQT8|Q8 AQT8_9HIV1,

|82296647|sp|Q8AQS0|Q8AQS0_9HrVl,

182296645jsp j Q8 AQR8 |Q8 AQR8_9HIV 1,

|82296643|sp|Q8AQR6|Q8AQR6_9HIVl,

|82296641 |sp|Q8AQR4|Q8AQR4_9HrVl,

|82296639|sp|Q8AQR2|Q8AQR2_9EQVl,

|82296637|sp|Q8AQR0|Q8AQR0_9HIVl,

|82296635|sp|Q8AQQ8|Q8AQQ8_9fflVl,

|82296633|sp|Q8AQQ6|Q8AQQ6_9HIVl,

182296631 |sp|Q8AQQ4|Q8 AQQ4_9HIV1,

|82296629|sp|Q8AQQ2|Q8AQQ2_9HIVl,

|82296627|sp|Q8AQQ0|Q8AQQ0_9HIVl,

|82296625|sp|Q8AQP8|Q8AQP8_9HIVl,

|82296622|sp|Q8AQP5|Q8AQP5_9fflVl,

|82296620|sp|Q8AQP3|Q8AQP3_9HIVl5

|82296618|sp|Q8AQPl|Q8AQPl_9HIVl,

|82296616|sp|Q8AQN9|Q8AQN9_9HIVl,

182296613|sp |Q8 AQN6 |Q8 AQN6_9HIV 1,

182296611 |sp|Q8AQN4|Q8AQN4_9HIVl,

|82296609|sp]Q8AQN2|Q8AQN2_9HIVl,

|82296607|sp|Q8AQN0|Q8AQN0_9HIVl,

|82296605|sp|Q8AQM8|Q8AQM8_9HrVl,

|82296603|sp|Q8AQM6|Q8AQM6_9HIVl,

182296601 |sp|Q8AQM4|Q8AQM4_9HIVl,

|82296946|sp|Q8J3Ll|Q8J3Ll_9HTVl|82296944|sp|Q8J3K9|Q8J3K9_9HTVl|82296942|sp|Q8J3K7|Q8J3K7_9HIVl|82296828|sp|Q8J310|Q8J310_9fflVl|82296801 |sp|Q8AU85|Q8AU85_9HIVl|82296797|sp|Q8AU67|Q8AU67_9HrVl|82296794|sp|Q8AU56|Q8AU56_9HIVl|82296792|sp|Q8AU54|Q8AU54_9HIVl|82296790|sp|Q8AU52|Q8AU52_9HIVl|82296788|sp|Q8AU50|Q8AU50_9HIVl|82296786|sp|Q8AU48|Q8AU48_9HIVl|82296784|sp|Q8AU46|Q8AU46_9HIVl|82296782|sp|Q8AU44|Q8AU44_9HrVl|82296780|sp|Q8AU42|Q8AU42_9HIVl|82296778|sp|Q8AU40|Q8AU40_9fflVl|82296776|sp|Q8AU38|Q8AU38_9HIVl|82296774|sp|Q8AU36|Q8AU36_9HIVl|82296772|sp|Q8AU34|Q8AU34_9fflVl|82296770!sp!Q8AU32!Q8AU32_9HIVl|82296768Ísp|Q8AU30ÍQ8AU30_9HIVl|82296766|sp|Q8AU28|Q8AU28_9HIVl|82296764|sp|Q8AU26|Q8AU26_9HIVl|82296730|sp|Q8ATNl|Q8ATNl_9HTVl|82296653|sp|Q8AQU7|Q8AQU7_9HIVl|82296649|sp|Q8AQS9|Q8AQS9_9HIVl|82296646|sp|Q8AQR9|Q8AQR9_9HIVl182296644|sp |Q8 AQR7 |Q8 AQR7_9HTV 1|82296642jsp |Q8 AQR5 |Q8 AQR5_9KDV 1|82296640|sp|Q8AQR3|Q8AQR3_9HIVl|82296638|sp|Q8AQRl |Q8AQR1_9HIV1|82296636|sp|Q8AQQ9|Q8AQQ9_9HIVl]82296634|sp|Q8AQQ7|Q8AQQ7_9HIVl|82296632|sp|Q8AQQ5|Q8AQQ5_9fflVl|82296630|sp|Q8AQQ3|Q8AQQ3_9HIVl|82296628|sp|Q8AQQl |Q8AQQ1_9HIV1|82296626|sp|Q8AQP9|Q8AQP9_9HIVl|82296623 |sp| Q8 AQP6 |Q8 AQP69HIV1|82296621 |sp|Q8AQP4|Q8AQP4_9HIVl|82296619|sp|Q8AQP2|Q8AQP2_9HrVl|82296617|sp|Q8AQP0|Q8AQP0_9HIVl|82296615|sp|Q8AQN8|Q8AQN8_9HIVl|82296612|sp|Q8AQN5|Q8AQN5_9HIVl]82296610|sp|Q8AQN3|Q8AQN3_9HIVl|82296608|sp|Q8AQNl|Q8AQNl_9HIVl|82296606|sp|Q8AQM9|Q8AQM9_9HIVl|82296604|sp|Q8AQM7|Q8AQM7_9HIVl|82296602|sp|Q8AQM5|Q8AQM5_9HIVl|82296600|sp|Q8AQM3|Q8AQM3_9HIVl|82296599|sp|Q8AQM2|Q8AQM2_9HIVl,

|82296369|sp|Q8AMH3|Q8AMH3_9HrVl,

|82296367|sp|Q8AMHl|Q8AMHl_9HIVl,

|82296365|sp|Q8AMG9|Q8AMG9_9HIVl,

|82296363|sp|Q8AMG7|Q8AMG7_9HIVl,

|82296361 |sp|Q8AMG5|Q8AMG5_9fflVl,

|82296359|sp|Q8AMG3|Q8AMG3_9HIVl,

|82296357|sp|Q8AMGl|Q8AMGl_9HIVl5

|82296355|sp|Q8AMF9|Q8AMF9_9HIVl,

|82296353|sp|Q8AMF7|Q8AMF7_9HIVl,

|82296351 jsp |Q8AMF5 |Q8 AMF5_9HIV1,

182296349jsp |Q8 AMF31Q8 AMF3_9HIV 1,

|82296347|sp|Q8AMFl|Q8AMFl_9HIVl,

j82296345j sp|Q8 AME91Q8 AME9_9HIV 1,

182296343 |sp|Q8AME7|Q8AME7_9HIVl,

|82296341 |sp|Q8AME5 |Q8AME5_9HIV1,

|82296339|sp|Q8AME3|Q8AME3_9HIVl,

|82296337|sp|Q8AMEl |Q8AME1_9HIV1,

]82296335|sp]Q8AMD9ln8AMD9 9HIV1

|82296241 |sp|Q8AK08|Q8AK08_9ÍHIVl, '

|82295651|sp|Q8AF20|Q8AF20_9HIVl,

|82295602|sp|Q8AE65|Q8AE65_9HIVl,

|82295596|sp|Q8AE49|Q8AE49_9HIVl,

|82295590|sp|Q8AE33|Q8AE33_9HIVl,

|82295584|sp|Q8AE16|Q8AE16_9HQYl,

|82295578|sp|Q8AEOO|Q8AEOO_9HIVl,

|82295572|sp|Q8ADY4|Q8ADY4_9HIVl,

|82295566|sp|Q8ADW8|Q8ADW8_9HIVl,

|82295560|sp|Q8ADV2|Q8ADV2_9HIVl,

|82295554|sp|Q8ADT6|Q8ADT6_9HIVl,

|82295548|sp|Q8ADS0|Q8ADS0_9BQYl,

|82295542|sp|Q8ADQ4|Q8ADQ4_9HIVl,

|82295536|sp|Q8ADN8|Q8ADN8_9HIVl,

|82295533|sp|Q8ADN0|Q8ADN0_9fflVltniiicadfl,

|82295531 |sp|Q8ADM2|Q8ADM2_9HIVl,

|82295523|sp|Q8ADJ8|Q8ADJ8_9HIVl,

|82295514|sp|Q8ADI2|Q8ADI2_9HIVl,

|82295508|sp|Q8ADG6|Q8ADG6_9HIVl,

|82295502|sp|Q8ADF0|Q8ADF0_9HIVl,

|82295496|sp|Q8ADD4|Q8ADD4_9HIVl,

|82295490|sp|Q8ADB8|Q8ADB8_9HIVl,

|82295484|sp|Q8ADA2|Q8ADA2_9HIVl,

|82295478|sp|Q8AD86|Q8AD86_9HIVl,

|82295472|sp|Q8AD70|Q8AD70_9HIVl,

|82295430|sp|Q8AC81 |Q8AC81_9HIV1,

|82295426|sp|Q8AC64|Q8AC64_9HIVl,

|82293901|sp|Q80156|Q80156_9HIVl,

|82293609|sp|Q7ZMH4|Q7ZMH4_9HIYl,

|82296370|sp|Q8AMH4|Q8AMH4_9HIVl|82296368|sp|Q8AMH2|Q8AMH2_9HrVl|82296366|sp|Q8AMH0|Q8AMH0_9HIVl|82296364|sp|Q8AMG8|Q8AMG8_9HIVl|82296362|sp|Q8AMG6|Q8AMG6_9HIVl|82296360|sp|Q8AMG4|Q8AMG4_9HIVl|82296358|sp|Q8AMG2|Q8AMG2_9HIVl|82296356|sp|Q8AMGO|Q8AMGO_9HIVl|82296354|sp|Q8AMF8|Q8AMF8_9HTVl|82296352|sp|Q8AMF6|Q8AMF6_9HrVl|82296350|sp|Q8AMF4|Q8AMF4_9HIVl|82296348jsp |Q8 AMF2 |Q8 AMF2_9HTV 1|82296346|sp|Q8AMF0|Q8AMF0_9fflVl|82296344|sp|Q8AME8|Q8AME8_9HTVl|82296342|sp|Q8AME6|Q8AME6_9HIVl|82296340|sp|Q8AME4|Q8AME4_9Hrvl|82296338|sp|Q8AME2|Q8AME2_9HIVl|82296336|sp|Q8AME0|Q8AME0_9HIVl]82296334|s"lQ8AMD8lQ8AMD8 9HIV1|82296239|sp|Q8AJz'9|Q8AJZ9~9HIVl|82295605|sp|Q8AE73|Q8AE73_9HTVl|82295599|sp|Q8AE57|Q8AE57_9HrVl182295593 |sp|Q8AE41|Q8AE41_9HIVl|82295587|sp|Q8AE25|Q8AE25_9HIVl|8229558 l|sp|Q8AE08|Q8AE08_9HIVl|82295575|sp|Q8ADZ2|Q8ADZ2_9HIVl|82295569|sp|Q8ADX6jQ8ADX6_9HIVl|82295563|sp|Q8ADW0|Q8ADW0_9HIVl|82295557|sp|Q8ADU4|Q8ADU4_9HIVl18229555 l|sp|Q8ADS8|Q8ADS8_9HIVl|82295545|sp|Q8ADR2|Q8ADR2_9HTVl|82295539|sp|Q8ADP6|Q8ADP6_9HTVl

|82295528|sp|Q8ADL4|Q8ADL4_9HIVl3|82295520|sp|Q8ADJO|Q8ADJO_9fflVl,|82295511 |sp|Q8ADH4|Q8ADH4_9HIVl,|82295505|sp|Q8ADF8|Q8ADF8_9HIVl,|82295499|sp|Q8ADE2|Q8ADE2_9HIVl,|82295493|sp|Q8ADC6|Q8ADC6_9HIVl,|82295487|sp|Q8ADB0|Q8ADB0_9HIVl,|8229548 l|sp|Q8AD94|Q8AD94_9HIVl,Í82295475|sp|Q8AD78|Q8AD78_9HTVl,|82295435|sp|Q8ACA6|Q8ACA6_9HIVl)|82295428|sp|Q8AC73|Q8AC73_9HIVl,|82295416|sp|Q8AC02|Q8AC02_9HIVl,|82293611 |sp|Q7ZMD |Q7ZMI3_9HIV1,|82293607|sp|Q7ZMG6|Q7ZMG6_9HIVl,|82293605|sp|Q7ZMF6|Q7ZMF6_9HIVl,

|82293474|sp|Q7ZJG5|Q7ZJG5_9HIVl,

j82293470|sp |Q7ZJE5 |Q7ZJE5_9HTV 1,

|82293466|sp|Q7ZJC7|Q7ZJC7_9mVl,

|82293462|sp|Q7ZJB0|Q7ZJB0_9HIVl,

|82293459|sp|Q7ZJ98|Q7ZJ98_9fflVl,

|82293453|sp|Q7ZJ82|Q7ZJ82_9HIVl,

182293451 |sp|Q7ZJ80|Q7ZJ80_9HIVl,

|82293449|sp|Q7ZJ78|Q7ZJ78_9HrV,l,

|82293447|sp|Q7ZJ76|Q7ZJ76_9HIVl,

|82293445|sp|Q7ZJ74|Q7ZJ74_9HIVl,

|82293443|sp|Q7ZJ72|Q7ZJ72_9HrVl,

|82293441 |sp|Q7ZJ70|Q7ZJ70_9HIVl,

|82293439|8ρ|ρ7ΖΙ68]ρ7Ζ168_9Ηΐνΐ5

|82293437|sp|Q7ZJ66|Q7ZJ66_9HIVl,

|82293435|sp|Q7ZJ64|Q7ZJ64_9HIVl,

|82293433|sp|Q7ZJ62|Q7ZJ62_9fflVl,

(8229343 ljsp|Q7ZJ60Q7ZJ60_9HIVl,

j82293429|spjQ7Zj58jQ7Zj58_9HIYÍ,

|82293427|sp|Q7ZJ56|Q7ZJ56_9HIVl,

|82293425|spjQ7ZJ54|Q7ZJ54_9HIVl,

|82293423|sp|Q7ZJ51|Q7ZJ51_9HIVl,

|82293421|sp|Q7ZJ49|Q7ZJ49_9HIVl,

|82293419|sp|Q7ZJ47|Q7ZJ47_9HIVl,

|82293417|sp|Q7ZJ45|Q7ZJ45_9mVl,

|82293415|sp|Q7ZJ43|Q7ZJ43_9HIVl,

|82293413 |sp|Q7ZJ41|Q7ZJ41_9HIVl,

182293411 |sp|Q7ZJ39|Q7ZJ39_9HIVl,

|82293409|sp|Q7ZJ37|Q7ZJ37_9HIVl,

|82293407|spjQ7ZJ35|Q7ZJ35_9HIVl,

|82293405|sp|Q7ZJ33|Q7ZJ33_9HIVl,

|82293403|sp|Q7ZJ31 |Q7ZJ31_9HIV1,

|82293257|sp|Q7ZFG8|Q7ZFG8_9HIVl,

|82293255|sp|Q7ZFG6|Q7ZFG6_9HIVl,

|82293253|sp|Q7ZFG4|Q7ZFG4_9HIVl,

|82293251]sp|Q7ZFG2|Q7ZFG2_9fflVl,

182293249jsp |Q7ZFG0| Q7ZFG0_9HIV 1,

|82293247|sp |Q7ZFF8 |Q7ZFF8_9HIV 1,

j82293245jsp IQ7ZFF6 |Q7ZFF6_9HIV 1,

j82293243 jsp I Q7ZFF4|Q7ZFF4_9HIV 1,

Í8229324ljspjQ7ZFF2ÍQ7ZFF2_9HIVl,

j82293239|spjQ7ZFF0ÍQ7ZFF0_9HIVl5

j82293237ÍspjQ7ZFE8|Q7ZFE8_9HIVl,

j82293235jspÍQ7ZFE6ÍQ7ZFE6_9HIVl,

j82293233|spÍQ7ZFE4ÍQ7ZFE4_9HIVl,

Í82293231 jspÍQ7ZFE2ÍQ7ZFE2_9HIVl5

|82293229jspÍQ7ZFE0ÍQ7ZFE0_9HIVl5

Í82293227jspjQ7ZFD8[Q7ZFD8_9HIVl,

182293476|sp |Q7Z JJ0|Q7Z JJ0_9HIV 1|82293472|sp|Q7ZJF4|Q7ZJF4_9HIVl|82293468|sp|Q7ZJD6|Q7ZJD6_9HIVl|82293464|sp |Q7ZJB9 |Q7ZJB9_9HIV 1|82293460|sp|Q7ZJA2|Q7ZJA2_9HIVl|82293456|sp|Q7ZJ86|Q7ZJ86_9HTVlj82293452jsp|Q7ZJ81ÍQ7ZJ81_9HIV1|82293450jspjQ7ZJ79ÍQ7ZJ79_9HIVlj82293448jspÍQ7ZJ77ÍQ7ZJ77_9HIVl|82293446ÍspÍQ7ZJ75jQ7ZJ75_9HIVlÍ82293444jspjQ7ZJ73|Q7ZJ73_9HIVlÍ82293442|spjQ7ZJ7lÍQ7ZJ71_9HIVl|82293440|sp|Q7ZJ69|Q7ZJ69_9HQYlj82293438Ísp|Q7ZJ67ÍQ7ZJ67_9HIVlÍ82293436jsp|Q7ZJ65|Q7ZJ65_9HIVlj82293434jsp|Q7ZJ63ÍQ7ZJ63_9HIVl|82293432|sp|Q7ZJ61 |Q7ZJ61_9HIV1|82293430|sp|Q7ZJ59|Q7ZJ59_9HIVlj82293428jspjQ7Zj57|Q7Zj57_9HIVl|82293426|sp|Q7ZJ55|Q7ZJ55_9HIVl|82293424|sp|Q7ZJ53|Q7ZJ53_9HIVl|82293422|sp|Q7ZJ50|Q7ZJ50_9HIVl|82293420|sp|Q7ZJ48|Q7ZJ48_9HIVl|82293418|sp|Q7ZJ46|Q7ZJ46_9fflVl182293416|sp|Q7ZJ44|Q7ZJ44_9HIVl|82293414|sp|Q7ZJ42|Q7ZJ42_9HrVl|82293412|sp|Q7ZJ40|Q7ZJ40_9HIVl|82293410|sp|Q7ZJ3 8 |Q7ZJ3 8_9HTV 1|82293408jsp|Q7ZJ3 6 |Q7Z J3 6_9HIV 1|82293406|sp|Q7ZJ34|Q7ZJ34_9EDVl|82293404|sp|Q7ZJ32|Q7ZJ32_9HIVl|82293258|sp|Q7ZFG9|Q7ZFG9_9HIVl|82293256|sp|Q7ZFG7|Q7ZFG7_9fflVl|82293254|sp|Q7ZFG5|Q7ZFG5_9HrVl|82293252|sp|Q7ZFG3|Q7ZFG3_9HIVl|82293250|sp|Q7ZFGl|Q7ZFGl_9HIVl|82293248|sp|Q7ZFF9|Q7ZFF9_9fflVl|82293246|sp|Q7ZFF7|Q7ZFF7_9HIVl|82293244|sp|Q7ZFF5 |Q7ZFF5_9HIV 1|82293242|sp|Q7ZFF3|Q7ZFF3_9HIVl|82293240|sp|Q7ZFFl |Q7ZFF1_9HIV1|8229323 8 |sp|Q7ZFE9|Q7ZFE9_9HIV 1|82293236|sp|Q7ZFE7|Q7ZFE7_9HTVl|82293234|sp|Q7ZFE5|Q7ZFE5_9HIVl|82293232|sp|Q7ZFE3|Q7ZFE3_9HIVl|82293230|sp|Q7ZFEl |Q7ZFE1_9HIV1|82293228|sp|Q7ZFD9|Q7ZFD9_9HIVl|82293226|sp|Q7ZFD7|Q7ZFD7_9HIVl82293225|sp|Q7ZFD6|Q7ZFD6_9HIVl,82293223|sp|Q7ZFD4|Q7ZFD4_9HIVl,82293221 |sp|Q7ZFD2|Q7ZFD2_9HIV 1,82293219|sp|Q7ZFD0|Q7ZFD0_9HIVl,82293217|sp|Q7ZFC8|Q7ZFC8_9mVl,82293215|sp|Q7ZFC6|Q7ZFC6_9fflVl,82293 213 |sp|Q7ZFC4|Q7ZFC4_9HIVl,8229321 l|sp|Q7ZFC2|Q7ZFC2_9HIVl,82293209|sp|Q7ZFC0|Q7ZFC0_9fflVl,82293207|sp|Q7ZFB8|Q7ZFB8_9HIVl,82293161 jsp|Q7ZC20|Q7ZC20_9HIVl,82293159|sp|Q7ZB W9|Q7ZBW9_9HIV 1,82293157|sp|Q7ZBW7|Q7ZBW7_9HIVl,82293155|sp|Q7ZBW5|Q7ZBW5_9HIVl,82293153|sp|Q7ZBW3 |Q7ZBW3_9HIV1,82293151 |sp|Q7ZBWl |Q7ZB W1_9HIV1,82293149|sp|Q7ZBV9|Q7ZBV9_9HIVl,82293147|sp|Q7ZBV7|Q7ZBV7_9HrVl,82293 Í45|spiQ7ZBV5 jQ7ZBV5_3KIVl,82293143|sp|Q7ZBV3]Q7ZBV3_9HIVl,82293141 |sp|Q7ZBVl |Q7ZBV1_9HIV1,82293139|sp|Q7ZBU9|Q7ZBU9_9HIVl,82293137|sp|Q7ZBU7|Q7ZBU7_9HIVl,8229313 5 |sp|Q7ZBU4|Q7ZBU4_9HrVr 1,82293133|sp|Q7ZBU2]Q7ZBU2_9HIV 1,82293131 |sp|Q7ZBU0|Q7ZBU0_9HIV 1,82293129|sp|Q7ZBT8|Q7ZBT8_9HIVl,82293096|sp|Q7ZAP6|Q7ZAP6_9HIVl,82293094|sp|Q7ZAP4|Q7ZAP4_9HIVl,82292626|sp|Q7SV30]Q7SV30_9HIVl,82292620|8ρ|ρ78νΐ2|ρ78νΐ2_9Ηΐνΐ,82292614|sp|Q7SUZ4|Q7SUZ4_9HIVl,82292609|sp|Q7SUX8|Q7SUX8_9HrVl,82292218|sp|Q7SQM7|Q7SQM7_9mVl,82292214|sp)Q7SQAl|Q7SQAl_9HIVl,82292168|sp|Q7SQ38|Q7SQ38_9EnVl,82292152|sp|Q7SPT2|Q7SPT2_9HIVl,82291716|sp|Q7SKG3|Q7SKG3_9HTVl,82291401 |sp|Q7SII6|Q7SII6_9HIV 1,82290717|sp|Q78244|Q78244_9HIV 1,82289495|sp|Q74825|Q74825_9HIVl,82289493 |sp|Q74823|Q74823_9HIVl,82288905|sp|Q72994|Q72994_9HTVl>82288635|sp|Q71VG3|Q71VG3_9HIVl382288629|sp]Q71AX5|Q71AX5_9HIVl,82288536|sp|Q71820|Q71820_9HIVl,82288464|sp|Q70XD2 |Q70XD2_9HIV 1,82288062|sp|Q70154|Q70154_9HIV1,

|82293224|sp|Q7ZFD5|Q7ZFD5_9HTVl|82293222|sp|Q7ZFD3|Q7ZFD3_9HIVl|82293220|sp|Q7ZFDl |Q7ZFD1_9HIV 1|82293218|sp|Q7ZFC9|Q7ZFC9_9HIVlj82293216jsp |Q7ZFC7 |Q7ZFC7_9HIV 1|82293214|sp|Q7ZFC5|Q7ZFC5_9HrVl|82293212|sp|Q7ZFC3 |Q7ZFC3_9HIV1|82293210|sp|Q7ZFC 1 |Q7ZFC 1_9HTV1|82293208|sp|Q7ZFB9|Q7ZFB9_9fflVl|82293206|sp|Q7ZFB7|Q7ZFB7_9HIVl|82293160|sp|Q7ZBX0|Q7ZBX0_9HTVl|8229315 8|sp|Q7ZBW8 |Q7ZBW8_9HIV1|82293156|sp|Q7ZBW6|Q7ZBW6_9fflVl|82293154|sp|Q7ZBW4|Q7ZBW4_9HIVl|82293152|sp|Q7ZBW2|Q7ZBW2_9HIVl|82293150|sp|Q7ZBW0|Q7ZBW0_9HIVl|82293148|sp|Q7ZBV8|Q7ZBV8_9fflVl|82293146|sp|Q7ZBV6|Q7ZBV6_9HIVl|82293144|sp|Q7ZBY4|Q7ZBV4_9HTVl|82293142]sp|Q7ZBV2|Q7ZBV2_9HIVl|82293140|sp|Q7ZBV0|Q7ZBV0_9fflVl|82293138|sp|Q7ZBU8|Q7ZBU8_9HTVl|82293136|sp|Q7ZBU5|Q7ZBU5_9HIVl|82293134|sp|Q7ZBU3|Q7ZBU3_9HTVl|82293132|sp|Q7ZBUl ]Q7ZBU1_9HIV1|82293130|sp|Q7ZBT9|Q7ZBT9_9HIVl|82293121|sp|Q7ZBG0|Q7ZBG0_9HIVl|82293095|sp|Q7ZAP5|Q7ZAP5_9HIVl|82292629|sp|Q7SV37|Q7SV37_9HIVl|82292623|sp|Q7SV21|Q7SV21_9HIVl|82292617|sp|Q7SV03|Q7SV03_9HIVl|82292612|sp|Q7SUY7|Q7SUY7_9fflVl|82292606|sp|Q7SUW9|Q7SUW9_9HIVl|82292216|sp|Q7SQA6|Q7SQA6_9HIVl|82292170)sp|Q7SQ47|Q7SQ47_9HIVl|82292155|sp|Q7SPU2|Q7SPU2_9HTVl|82291718|sp|Q7SKH2|Q7SKH2_9HIVl|82291714|sp|Q7SKF4|Q7SKF4_9HIV 1|82291396|sp|Q7S]H6|Q7SIH6_9HIVl|82290250|sp|Q77378|Q77378_9HTVl|82289494|sp|Q74824|Q74824_9HIVl|82289492|sp|Q74813 |Q74813_9HIV1|82288902|sp|Q72985|Q72985_9HIVl|82288631 |sp|Q71 AY4|Q71 AY4_9HIV1|82288627|sp | Q71AW6 |Q71 AW6_9HIV1|82288467|sp|Q70XD9|Q70XD9_9HIVl182288461 |sp|Q70XC5|Q70XC5_9HIVl18228805 9|sp|Q70143jQ70143_9HIV 182288008|sp|Q6Y940|Q6Y940_9HTVl,

82288004|sp|Q6Y922|Q6Y922_9HIVl,

82288000|sp|Q6Y904|Q6Y904_9HIVl>

82287997|sp|Q6Y8Y6|Q6Y8Y6_9HIVl,

82287993 |sp|Q6Y8W8|Q6Y8W8_9KQVl,

82287989|sp|Q6Y8V0|Q6Y8V0_9HIVl,

82287985 |sp|Q6Y8T3 |Q6Y8T3_9fflVl,

82287980|sp|Q6Y8R5|Q6Y8R5_9HIVl,

82287923 |sp|Q6XKB5|Q6XKB5_9HIVl,

82287892|sp|Q6X6Wl|Q6X6Wl_9HIVl5

82287888|sp|Q6X6T5|Q6X6T5_9HIVl,

822878 84|sp|Q6X6R7|Q6X6R7_9HIVl,

82287880|sp|Q6X6P2|Q6X6P2_9HIVl,

82287876|sp|Q6X6L6|Q6X6L6_9HIVl,

82287872|sp|Q6X6J8|Q6X6J8_9HIVl,

82287868|sp|Q6X6G6|Q6X6G6_9HIV].,

82287557|sp|Q6V3U8|Q6V3U8_9HIVl,

82287553|sp|Q6V3S5|Q6V3S5_9HIVl,

82287372|sp|Q6TJRKl |Q6URH1_9HP/1,

82287370|sp|Q6URG9|Q6URG9_9HIYl,

82287368|sp|Q6URG7|Q6URG7_9HIVl,

82287366|sp|Q6URG5|Q6URG5_9HIVl,

82287364|sp|Q6URG3|Q6URG3_9HIVl,

82287362|sp|Q6URGl|Q6URGl_9HIVl,

82287360|sp|Q6URF9|Q6URF9_9fflVl,

82287357|sp|Q6URF6|Q6URF6_9HIVl,

822873 54|sp|Q6URF3|Q6URF3_9HIVl,

82287352|sp|Q6URPljQ6URFl_9EQYl,

82287350|sp|Q6URE9|Q6URE9_9HIVl,

82287348|sp|Q6URE7|Q6URE7_9HIVl,

82287346|sp|Q6URE4|Q6URE4_9HIVl,

82287344|sp|Q6URE2|Q6URE2_9HrVl,

82287342|sp|Q6URE0|Q6URE0_9fflVl,

82287340|sp|Q6URD8|Q6URD8_9HIVl,

82287338|sp|Q6URD6|Q6URD6_9HIVl,

82287336|sp|Q6URD4|Q6URD4_9HIVl,

82287334|sp|Q6URD2|Q6URD2_9HIVl,

82287332|sp|Q6XJRDO|Q6URDO_9HIVl,

82287330|sp|Q6URC7|Q6URC7_9HIVl,

82287239|sp|Q6UFP5|Q6UFP5_9HIVl,

82287234|sp|Q6UFL9|Q6UFL9_9fflVl,

82287231 |sp|Q6UFK4|Q6UFK4_9HIVl,

82287227|sp|Q6UFI6|Q6UFI6_9HTVl,

82287223|sp|Q6UFG8|Q6UFG8_9HIVl,

82287219|sp|Q6UFFl |Q6UFF1_9HIV1,

82287215|sp|Q6UFDl |Q6UFD1_9HIV1,

8228721 l|sp|Q6UFB3|Q6UFB3_9HIVl,

82287207|sp|Q6UF95|Q6UF95_9HIVl,

|82288006|sp|Q6Y931 |Q6Y931_9HIV1,|82288002|sp|Q6Y913 |Q6Y913_9ETV 1,|82287999|sp|Q6Y8Z5|Q6Y8Z5_9HTVl,|82287995|sp|Q6Y8X7|Q6Y8X7_9HTVl,|82287991 |sp|Q6Y8V9|Q6Y8V9_9HIVl,|82287987|sp|Q6Y8Ul|Q6Y8Ul_9HTVl,|82287983|sp|Q6Y8S4|Q6Y8S4_9HIVl,|82287925|sp|Q6XKC4|Q6XKC4_9HIVl,|82287894|sp|Q6X6X0|Q6X6X0_9HIVl,|82287890|sp|Q6X6U4|Q6X6U4_9HTVl,|82287886|sp|Q6X6S6|Q6X6S6_9HTVl,|82287882|sp|Q6X6Ql|Q6X6Ql_9HTVl,|82287878|sp|Q6X6N3|Q6X6N3_9HIVl,|82287874|sp|Q6X6K7|Q6X6K7_9HTVl,|82287870|sp|Q6X6I3|Q6X6I3_9HTVl,|8228781 l|sp|Q6WS68|Q6WS68_9HIVl,|82287554|sp|Q6V3T3|Q6Y3T3_9HIVl,|82287373|sp|Q6URH2|Q6URH2_9HIVl,]82287371 !sp|Q6URH0!Q6URH0_9HTV 1,Í82287369ÍspÍQ6URG8jQ6URG8_9HIVl,|82287367|sp|Q6URG6|Q6URG6_9HIVl,|82287365|sp|Q6URG4|Q6URG4_9HTVl,|82287363|sp|Q6URG2|Q6URG2_9HrVl,|82287361|sp|Q6URG0|Q6URG0_9HIVl,|82287359|sp]Q6URF8|Q6URF8_9HIVl,|82287356|sp]Q6URF5|Q6URF5_9HrVl,|82287353 |sp|Q6URF2|Q6URF2_9HIVl,|82287351 |sp|Q6URF0|Q6URF0_9HIVl,|82287349|sp|Q6URE8|Q6URE8_9HIVl,|82287347|sp|Q6URE5|Q6URE5_9HIVl,|82287345|sp|Q6URE3|Q6URE3_9HTVl,|82287343|sp|Q6UREl|Q6UREl_9mVl,|82287341|sp|Q6URD9|Q6URD9_9HIVl,|82287339|sp|Q6URD7|Q6URD7_9HIVl,|82287337|sp|Q6URD5|Q6URD5_9HIVl,182287335 |sp|Q6URD3 |Q6URD3_9HIV1,|82287333|sp|Q6URDl|Q6URDl_9HIVl,|82287331 |sp|Q6URC8|Q6URC8_9HIVl,|82287241 |sp|Q6UFQ4|Q6UFQ4_9HIVl,|82287237|sp|Q6UFN6|Q6lIFN6_9HIVl,|82287233|sp|Q6UFL3|Q6UFL3_9HIVl,|82287229|sp|Q6UFJ5|Q6UFJ5_9fflVl,|82287225|sp|Q6UFH7|Q6UFH7_9HIVl,|82287221|sp|Q6UFF9|Q6lJFF9_9HIVl,|82287217|sp|Q6UFE2|Q6UFE2_9HIVlJ|82287213|sp|Q6UFC2|Q6UFC2_9HTVl,|82287209|sp|Q6UFA4|Q6UFA4_9HIVl,|82287205|sp|Q6UF86|Q6UF86_9HIVl,82287202|sp|Q6UF69|Q6UF69_9HrVl,

82287197|sp|Q6UF46|Q6UF46_9HIVl,

82287193|sp|Q6UF28|Q6UF28_9HIVl,

82287189|sp|Q6UF10|Q6UF10_9mVl,

82287185|sp|Q6UEZ5|Q6UEZ5_9HIVl,

82287181 |sp |Q6UEX7|Q6UEX7_9HIV1,

82287177|sp|Q6UEV9|Q6UEV9_9HIVl,

82287173|sp|Q6UEUl|Q6UEUl_9HIVl,

82287169|sp|Q6UES4|Q6UES4_9HIVl,

82287165|sp|Q6UEQ6|Q6UEQ6_9HIVl,

82287161 |sp|Q6UEN9|Q6UEN9_9HIVl,

82287157|sp|Q6UEM4|Q6UEM4_9HIVl,

82287153|sp|Q6UEK6|Q6UEK6_9HIVl,

82286728|sp|Q6SZV9|Q6SZV9_9mVl,

82286726|sp|Q6SZV7|Q6SZV7_9HIVl,

82286724|sp|Q6SZV4|Q6SZV4_9HIVl,

82286722|sp|Q6SZV2|Q6SZV2_9HIVl,

82286720|sp|Q6SZV0|Q6SZV0_9HTVl5

82286718|sp|Q6SZU8|Q6SZU8_9HIVl,

82286716|sp|Q6SZU6|Q6SZU6_9mVl,

82286474]sp|Q6S875|Q6S875_9HIVl,

82286470|sp|Q6S860|Q6S860_9HIVl,

82286466|sp)Q6S844|Q6S844_9HTVl,

82286462|sp|Q6S829|Q6S829_9HIVl,

82286459|sp|Q6S813 |Q6S813_9HIV 1,

82286455|sp|Q6S7Z6|Q6S7Z6_9HTVl,

82286451 |sp|Q6S7Y0|Q6S7 Y0_9HIV1,

82286447|sp|Q6S7W2|Q6S7W2_9HIVl,

82286443|splQ6S7U6|Q6S7U6_9ffiVl,

82286439|sp|Q6S7S9|Q6S7S9_9HIVl,

82286006|sp|Q6RJG5|Q6RJG5_9EDVl,

82286000|sp|Q6RJD7|Q6RJD7_9HIVl,

82285998]sp]Q6RJC3]Q6RJC3_9HIVl,

82285995|sp|Q6RJ81 |Q6RJ81_9HIV1,

82285993|sp|Q6RJ67|Q6RJ67_9HIVl,

82285991 |sp|Q6RJ53)Q6RJ53_9HIVl,

82285989|sp|Q6RJ39|Q6RJ39_9HIVl,

82285703|sp|Q6QKX8|Q6QKX8_9HIVl,

82285279|sp|Q6Q459|Q6Q459_9HTVl,

82285273|sp|Q6Q434|Q6Q434_9mVl,

82285212|sp|Q6Q2U7|Q6Q2U7_9HIVl,

82285056|sp|Q6PRC2|Q6PRC2_9HIVl,

82285054|sp|Q6PRB9|Q6PRB9_9HIVl,

82285052|sp|Q6PRB7|Q6PRB7_9HIVl,

82285050|sp|Q6PRB3|Q6PRB3_9HIVl,

82285048|sp|Q6PRBl IQ6PRB 1_9HIV1,

822850461sp|Q6PRA9|Q6PRA9_9HTV 1,

82285044|sp|Q6PRA6jQ6PRA6_9HIVl,

|82287199|sp|Q6UF55|Q6UF55_9HIVl,|82287195|sp|Q6UF37|Q6UF37_9HrVl,|82287191|sp|Q6UF19|Q6UF19_9HIVÍ,|82287187|sp|Q6UF04|Q6UF04_9HIVl,|82287183|sp|Q6UEY6|Q6UEY6_9HIVl,|82287179|sp|Q6UEW8|Q6UEW8_9HIVl,|82287175|sp|Q6UEV0)Q6UEV0_9HTVl,|82287171|sp|Q6UET2|Q6UET2_9fflVl,|82287167|sp|Q6UER5|Q6UER5_9HIVl,|82287163|sp|Q6UEP7|Q6UEP7_9fflVl,|82287159|sp|Q6UEN0|Q6UEN0_9HIVl,|8228715 5 |sp|Q6UEL5 |Q6UEL5_9HIV1,|82287151jsp|Q6UEJ7|Q6UEJ7_9HIVl,|82286727|sp|Q6SZV8|Q6SZV8_9HIVl,|82286725|sp|Q6SZV5|Q6SZV5_9H3Vl,|82286723|sp|Q6SZV3|Q6SZV3_9HTVl,|82286721|sp|Q6SZVl|Q6SZVl_9HIVl,|82286719|sp|Q6SZU9|Q6SZU9_9inyi,|82286717|sp|Q6SZU7iQ6SZÜ7_9iliVÍ,|82286476|sp|Q6S884|Q6S884_9fflVl,|82286472|sp|Q6S867|Q6S867_9HrVl,|82286468|sp[Q6S852|Q6S852_9HIVl,|82286464|sp|Q6S835|Q6S835_9fflVl,|82286460|sp|Q6S821|Q6S821_9HIVl,|82286457|sp|Q6S805|Q6S805_9HIVl,|82286453|sp|Q6S7Y9|Q6S7Y9_9HIVl,|82286449|sp|Q6S7Xl|Q6S7Xl_9HIVl,|82286445|sp|Q6S7V5|Q6S7V5_9HIVl,|82286441|sp|Q6S7T8|Q6S7T8_9HTVl,|82286437|sp|Q6S7S 1 |Q6S7S 1_9HIV1,|82286004|sp|Q6RJF8|Q6RJF8_9HrVl,|82285999|sp|Q6RJD0|Q6RJD0_9HTVl,|82285996|sp]Q6RJA2|Q6RJA2_9HIVl,|82285994|sp|Q6RJ74|Q6RJ74_9HIVl,|82285992|sp|Q6RJ60|Q6RJ60_9HIVl,|82285990|sp|Q6RJ46|Q6RJ46_9HIVl,|82285987|sp|Q6RFP0|Q6RFP0_9HIVl,|82285701|sp|Q6QKW9|Q6QKW9_9HIVl,|82285277|sp|Q6Q450|Q6Q450_9HIVl,|82285214|sp|Q6Q2V6|Q6Q2V6_9HIVl,|82285057|sp|Q6PRC4|Q6PRC4_9HIVl,|82285055|sp|Q6PRC0|Q6PRC0_9HTVl,|82285053|sp|Q6PRB8|Q6PRB8_9HTVl,|82285051|sp|Q6PRB6|Q6PRB6_9HIVl,|82285049|sp|Q6PRB2|Q6PRB2_9HIVl,|82285047|sp|Q6PRB0|Q6PRB0_9mVl,|82285045|sp|Q6PRA8|Q6PRA8_9HIVl,|82285043|sp|Q6PRA4|Q6PRA4_9HIVl,82285042|sp|Q6PRA3|Q6PRA3_9HIVl,

82285040isp|Q6PRA0|Q6PRA0_9HrVl,

82285038|sp|Q6PR97|Q6PR97_9HIVl,

82285036|sp|Q6PR94[Q6PR94_9HIVl,

82285034|sp|Q6PR92|Q6PR92_9HIVl,

82285032|sp|Q6PR90|Q6PR90_9HIVl,

82285030|sp|Q6PR86|Q6PR86_9HIVl3

82285028|sp|Q6PR84|Q6PR84_9HIVlJ

82285026|sp|Q6PR82|Q6PR82_9HIVl,

82285024|sp|Q6PR80|Q6PR80_9HIVl,

82285022|sp)Q6PR78|Q6PR78_9HIVl,

82285019|sp|Q6PR25|Q6PR25_9HIVl3

82285015|sp|Q6PR01|Q6PR01_9HIVl,

82284944|sp|Q6JP17|Q6JP17_9HIVl,

82284941 |sp|Q6JNZ9|Q6JNZ9_9fflVl,

82284938|sp|Q6JNYl|Q6JNYl_9HIVl,

82284934|sp|Q6JNW3|Q6JNW3_9HIVl,

82284930|sp|Q6JNU5 |Q6JNU5_9HIV1,

82284926|sp}Q6JNS7|Q6INS7_9fflVl,

82284924|sp|Q6JNQ9|Q6JNQ9_9HIVl,

82284920|sp|Q6JNPl|Q6JNPl_9fflVl,

82284916|sp|Q6JNM3|Q6JNM3_9HIVl,

82284912|sp|Q6JNK0|Q6JNK0_9HIVl,

82284908|sp |Q6JNI2|Q6 JNI2_9HIV1,

82284904|sp|Q6JNG6|Q6JNG6_9HIVl,

82284900|sp|Q6JNE8|Q6JNE8_9HIVl3

82284895|sp|Q6JND0|Q6JND0_9HIVl,

82284891 |sp|Q6JNB2|Q6JNB2_9HIVl,

82284887|sp|Q6JN95|Q6JN95_9HIVl,

82284883|sp|Q6JN77|Q6JN77_9HIVl5

82284826|sp|Q6IYB8|Q6IYB8_9HIVl,

82284824|sp|Q6IYB6|Q6IYB6_9HIVl,

82284822|sp|Q6rYB4|Q6IYB4_9HIVlJ

82284820|sp|Q6IYB2|Q6IYB2_9HIVl5

82284818|sp|Q6IYB0|Q6IYB0_9HIVl,

82284816|sp|Q6IYA8 |Q6IYA8_9HTV 1,

82284814|sp|Q61YA6|Q6IYA6_9HIVl,

82284812|sp|Q6IYA4|Q6IYA4_9HIV 1,

82284810|sp|Q6IYA2|Q6IYA2_9fflVl,

82284808|sp|Q6IYA0|Q6IYA0_9HIVl,

82284806|sp|Q6IY98|Q6IY98_9HIVl,

82284804|sp|Q6IY96|Q6IY96_9HIVl,

82284802|sp|Q6IY94|Q6IY94_9HIVl,

82284800|sp|Q6IY92|Q6IY92_9HIVl,

82284798|sp|Q6IY90|Q6IY90_9HIVl,

82284796|sp|Q6IY88)Q6IY88_9HIVl,

82284794|sp|Q6IY86|Q6IY86_9HIVl,

82284792|sp|Q6IY84)Q6IY84_9ETVl,

|82285041 |sp|Q6PRAl |Q6PRA1_9HIV1|82285039|sp|Q6PR98|Q6PR98_9HIVl|82285037|sp|Q6PR95|Q6PR95_9HTVl|82285035|sp|Q6PR93|Q6PR93_9mVl|82285033|sp|Q6PR91|Q6PR91_9HIVl|8228503 l|sp|Q6PR88|Q6PR88_9HIVl|82285029|sp|Q6PR85|Q6PR85_9HIVl|82285027|sp|Q6PR83|Q6PR83_9HIVl|82285025|sp|Q6PR81 |Q6PR81_9HIV1|82285023|sp|Q6PR79|Q6PR79_9HIVl|82285021|sp|Q6PR77|Q6PR77_9HIVlÍ82285017|sp|Q6PR16|Q6PR16_9mVl|82285013|sp|Q6PQZ4|Q6PQZ4_9HIVl|82284943|sp|Q6JP08|Q6JP08_9HTVl|82284940|sp|Q6JNZ0)Q6JNZ0_9HIVl|82284936|sp|Q6JNX2|Q6INX2_9mVl]82284932|sp|Q6JNV4|Q6JNV4_9HQYl|82284928|sp|Q6INT6|Q6JNT6_9HIVl|82284925|spjQóJiNll8jQ6JlNTl8_9íírv 1|82284922|sp|Q6JNQ0|Q6JNQ0_9HIVl|82284918|sp|Q6JNN2|Q6JNN2_9HIV 1|82284914|sp|Q6JNK9|Q6JNK9_9HIVl|82284910|sp|Q6JNJl|Q6JNJl_9HIVl|82284906|sp|Q6JNH5|Q6JNH5_9HIVl|82284902jsp|Q6INF7|Q6JNF7_9EQVl|82284897|sp|Q6JND9|Q6JND9_9HIVl|82284893|sp|Q6JNCl|Q6JNCl_9HTVl|82284889|sp|Q6JNA3|Q6JNA3_9HIVl|82284885|sp|Q6JN86|Q6JN86_9HIVl|82284881 |sp|Q6JN68|Q6JN68_9fflVl|82284825|sp|Q6IYB7|Q6IYB7_9HIVl|82284823|sp|Q6IYB5|Q6IYB5_9HIVl|82284821|sp|Q6IYB3|Q6IYB3_9HIVl|82284819|sp|Q6IYBl|Q6IYBl_9HTVl|82284817|sp|Q6IYA9|Q6IYA9_9HIVl|82284815|sp|Q6IYA7|Q6IYA7_9HIVl|82284813 |sp|Q6IYA5 |Q6IYA5_9HTV1|8228481 l|sp|Q6IYA3|Q6IYA3_9HIVl|82284809|sp|Q6IYAl |Q6IYA1_9HIV11822848071sp|Q6IY99 |Q6IY99_9HTV 1|82284805|sp|Q6IY97|Q6IY97_9HTVl|82284803|sp|Q6IY95|Q6IY95_9HIVl|82284801 |sp|Q6IY93 |Q6IY93_9HIV 1|82284799|sp|Q6IY91|Q6IY91_9HIVl|82284797|sp|Q6IY89|Q6IY89_9HIVl|82284795|sp]Q6IY87]Q6IY87_9HIVl|82284793|sp|Q6IY85|Q6IY85_9HIVl]82284791 |sp|Q6IY83 |Q6IY83_9HIV1|82284790|sp|Q6IY82|Q6IY82_9HIVl5

|82284788|sp|Q6IY80|Q6IY80_9HIVl,

|82284786|sp|Q6IY78|Q6IY78_9EQYl,

|82284784|sp|Q6IY76|Q6IY76_9fflVl,

|82284728|sp|Q6HlS6|Q6HlS6_9HIVl,

|82284724|sp|Q6HlQ8|Q6HlQ8_9HIVls

|82284720|sp|Q6HlP0|Q6HlP0_9HIVl,

|82284716|sp|Q6HlM2|Q6HlM2_9HIVl,

|82284700|sp|Q6EG57|Q6EG57_9HIVl,

|82284697|sp|Q6EG39|Q6EG39_9HIVl,

|82284694|sp|Q6EG21|Q6EG21_9HIVl,

|82284691|sp|Q6EFZ4|Q6EFZ4_9HIVl,

|82284688|sp|Q6EFX6|Q6EFX6_9HIVl,

|82284684|sp|Q6EFV8|Q6EFV8_9HIVl,

|82284680|sp|Q6EFM0|Q6EFM0_9HIVl,

|82284359|sp|Q69GS9|Q69GS9_9HIVl,

|82284354|sp|Q69GRl|Q69GRl_9fflVl,

|82284350|sp|Q69GP3|Q69GP3_9HIVl,

|82284346|sp!Q69GM5lQ69GM5 9HIV1,

|82283877|spÍQ673U3|Q673U3_9HIVl, '

|82283873|sp|Q672T4|Q672T4_9HIVl5

|82283869|sp|Q672R9|Q672R9_9HIVl,

|82283825|sp|Q66TS3|Q66TS3_9HIVl,

|82283821 |sp|Q66TQ5|Q66TQ5_9HIVl,

|82283278|sp|Q5UEG4|Q5UEG4_9HIVl,

j82283274|sp|Q5U9 A91Q5U9 A9_9HIV 1,

|82283270|sp|Q5U992|Q5U992_9fflVl,

|82283266|sp|Q5U977|Q5U977_9fflVl,

|82283263|sp|Q5U967|Q5U967_9HIVl,

|82283259|sp|Q5U944|Q5U944_9HIVl,

|82283256]sp|Q5U8K4|Q5U8K4_9HIVl,

|82283252|sp|Q5U8I6|Q5U8I6_9fflVl,

|82283248|sp|Q5U8G8|Q5U8G8_9HIVl,

|82283244|sp|Q5U8F0|Q5U8F0_9HIVl,

|82283239|sp|Q5U8C3|Q5U8C3_9HIVl,

|82283235|sp|Q5U8A5|Q5U8A5_9HIVl,

|82283231 |sp|Q5U887|Q5U887_9HIVl,

|82283228|sp|Q5SFQl|Q5SFQl_9HIVl,

|82283205]sp|Q5S3F9|Q5S3F9_9HIVl,

|82283203|sp|Q5S3F7|Q5S3F7_9fflVl,

|82283201|sp|Q5S3F5|Q5S3F5_9HIVl,

|82283199|sp|Q5S3F3|Q5S3F3_9HIVl,

|82283197|sp|Q5S3Fl|Q5S3Fl_9HIVl,

|82283195|sp]Q5S3E8|Q5S3E8_9HIVl,

|82283193|sp|Q5S3E6|Q5S3E6_9HIVl,

|82283191|sp|Q5S3E4|Q5S3E4_9HIVl,

|82283189|sp|Q5S3El |Q5S3E1_9HIV1,

|82283187|sp|Q5S3D9|Q5S3D9_9HIVl,

|82284789|sp|Q6IY81|Q6IY81_9HTVl|82284787|sp|Q6IY79|Q6rY79_9HIVl|82284785|sp|Q6IY77|Q6IY77_9HIVl|82284730|sp|Q6HlT5|Q6HlT5_9HIVl|82284726|sp|Q6HlR7|Q6HlR7_9HTVl|82284722|sp|Q6HlP9|Q6HlP9_9HIVl|82284718|sp|Q6HlNl |Q6H1N1_9HIV1|82284702|sp|Q6EG84|Q6EG84_9HIVl|82284699|sp|Q6EG48|Q6EG48_9HIVl|82284696jsp |Q6EG3 0| Q6EG30_9HTV 1|82284693|sp|Q6EG03|Q6EG03_9HIVl|82284690|sp|Q6EFY5|Q6EFY5_9HIVl|82284687|sp|Q6EFW7|Q6EFW7_9HIVl|82284682|sp|Q6EFM9|Q6EFM9_9HIVl|82284399|sp|Q6B4P0|Q6B4P0_9HIVl|82284356|sp|Q69GS0|Q69GS0_9HTVl|82284352|sp|Q69GQ2|Q69GQ2_9HTVl|82284348|sp|Q69GN4|Q69GN4_9HIVl]82283879|sp]Q673V6!Q673V6_9HIVlÍ82283875jsp|Q672U2ÍQ672U2_9HIVl|82283871 |sp|Q672S7|Q672S7_9HIVl|82283827|sp|Q66TT3|Q66TT3_9HIVl|82283823|sp|Q66TR5|Q66TR5_9HIVl|82283280|sp|Q5UEH3|Q5UEH3_9HIVl|82283276|sp|Q5U9B8|Q5U9B8_9HIVl|82283272|sp|Q5U9Al|Q5U9Al_9HIVl|82283268|sp|Q5U984|Q5U984_9HTVl|82283264|sp|Q5U968|Q5U968_9HIVl|82283261 |sp|Q5U960|Q5U960_9HIVl|82283257|sp|Q5U937|Q5U937_9HIVl|82283254|sp|Q5U8J5|Q5U8J5_9HIVl|82283250|sp|Q5U8H7|Q5U8H7_9HIVl|82283246|sp|Q5U8F9|Q5U8F9_9HrV 1|82283241 |sp|Q5U8D2|Q5U8D2_9HIVl|82283237|sp|Q5U8B4|Q5U8B4_9HIVl|82283233 |sp|Q5U896|Q5U896_9HTVl|82283229|sp|Q5U878|Q5U878_9HIVl|82283206|sp|Q5S3G0|Q5S3G0_9HIVl|82283204|sp|Q5S3F8|Q5S3F8_9fflVl|82283202|sp|Q5S3F6|Q5S3F6_9HTVl|82283200|sp|Q5S3F4|Q5S3F4_9HIVl|82283198|sp|Q5S3F2|Q5S3F2_9HIVl|82283196|sp|Q5S3E9|Q5S3E9_9HTVl|82283194|sp|Q5S3E7|Q5S3E7_9HIVl|82283192|sp|Q5S3E5|Q5S3E5_9HIVl|82283190|sp|Q5S3E2|Q5S3E2_9fflVl|82283188|sp|Q5S3E0|Q5S3E0_9HIVl|82283186|sp|Q5S3D8|Q5S3D8_9HIVl|82283185|sp|Q5S3D7|Q5S3D7_9HIVl,

|82283183|sp|Q5S3D4|Q5S3D4_9fflVl,

|82283181|sp|Q5S3Dl|Q5S3Dl_9mVl,

|82283179|sp|Q5S3C8|Q5S3C8_9HTVl,

|82283177|sp|Q5S3C6|Q5S3C6_9HIVl,

Í82283175|sp|Q5S3C3|Q5S3C3_9mVl,

|82283173|sp|Q5S3B9|Q5S3B9_9HIVl,

|82283171|sp|Q5S3B2|Q5S3B2_9HIVl,

|82283169|sp|Q5S3A9|Q5S3A9_9HTVl,

|82283167|sp|Q5S3A7|Q5S3A7_9HIVl,

|82283165|sp|Q5S3A5|Q5S3A5_9mVl,

|82283163|sp|Q5S3A2|Q5S3A2_9HIVl,

|82283161 |sp|Q5S3A0|Q5S3A0_9HIVl,

|82283159|sp|Q5S396|Q5S396_9HIVl,

|82283157|sp|Q5S394|Q5S394_9HrVl,

|82283155|sp|Q5S392|Q5S392_9HIVl,

|82283153|sp|Q5S389|Q5S389_9HIVl,

|8228315 l|sp|Q5S385|Q5S385_9HIVl,

j82283149jspjQ5S383|Q5S383_9HIVl,

|82283147|sp|Q5S380|Q5S380_9HIVl,

|822831451sp|Q5S374|Q5S374_9HIVl,

|82283143|sp|Q5S370|Q5S370_9HIVl,

|82283141 |sp|Q5S367|Q5S367_9HIVls

|82283139|sp|Q5S365|Q5S365_9mVl,

|82283137|spÍQ5S363|Q5S363_9mVl,

|82283135]sp|Q5S360|Q5S360_9HTVl,

|82283133|sp]Q5S358|Q5S358_9HIVl,

|82283131|sp|Q5S356|Q5S356_9HIVl,

|82283129|sp|Q5S354|Q5S354_9HIVl,

|82283127|sp|Q5S352|Q5S352_9BTVl,

|82283125|sp|Q5S349|Q5S349_9HTVl,

|82283123|sp|Q5S346|Q5S346_9HIVl,

|82283121 |sp|Q5S342]Q5S342_9HIVl,

|82283119|sp|Q5S338|Q5S338_9HIVl,

|82283117|sp|Q5S336|Q5S336_9HIVl)

|82283115|sp|Q5S331|Q5S331_9HIVl,

|82283113|sp|Q5S329|Q5S329_9HIVl j

|822831 ll|sp|Q5S325|Q5S325_9HIVl,

|82283109|sp|Q5S322|Q5S322_9HIVl,

|82283107|sp|Q5S314|Q5S314_9HIV1,

|82283105|sp|Q5S308|Q5S308_9HIVl,

|82283103|sp|Q5S306|Q5S306_9HIVl,

|82283101|sp|Q5S303|Q5S303_9HrVl,

|82283099|sp|Q5S300|Q5S300_9HIVl,

|82283097|sp|Q5S2Z8|Q5S2Z8_9HIVl)

|82283095|sp|Q5S2Z6|Q5S2Z6_9HTVl,

|82283093|sp|Q5S2Z4|Q5S2Z4_9HIVl,

|82283091 |sp|Q5S2Y8|Q5S2Y8_9fflVl,

|82283184|sp|Q5S3D6|Q5S3D6_9HIVl|82283182|sp|Q5S3D2|Q5S3D2_9HrVl|82283180|sp|Q5S3D0|Q5S3D0_9HIVl|82283178|sp|Q5S3C7|Q5S3C7_9HTVl|82283176|sp|Q5S3C5|Q5S3C5_9HIVl|82283174|sp|Q5S3C2|Q5S3C2_9fflVl|82283172|sp|Q5S3B7|Q5S3B7_9HIVl|82283170|sp|Q5S3B0|Q5S3B0_9mVl|82283168|sp|Q5S3A8|Q5S3A8_9HTVl|82283166|sp|Q5S3A6|Q5S3A6_9HIVl|82283164|sp|Q5S3A3|Q5S3A3_9HIVl|82283162|sp|Q5 S3 Al |Q5S3 A1_9HIV1|82283160|sp|Q5S397|Q5S397_9HIVl|82283158|sp|Q5S395|Q5S395_9HIVl|82283156|sp|Q5S393|Q5S393_9HIVl|82283154|sp|Q5S391|Q5S391_9HTVl|82283152|sp|Q5S387|Q5S387_9HIVl|82283150|sp|Q5S384|Q5S384_9MVll82283148|sp|Q5S382|Q5S382_9HIVl|82283146|spÍQ5S377|Q5S377_9HTVl|82283144|sp|Q5S371|Q5S371_9HTVl|82283142|sp|Q5S369|Q5S369_9HIVl|82283140|sp|Q5S366|Q5S366_9HIVl|82283138|sp|Q5S364|Q5S364_9HIVl|82283136|sp|Q5S362|Q5S362_9HIVl|82283134|sp|Q5S359|Q5S359_9HIVl|82283132|sp|Q5S357|Q5S357_9HIVl|82283130|sp|Q5S355|Q5S355_9HIVl|82283128|sp|Q5S353|Q5S353_9HTVl|82283126|sp|Q5S350|Q5S350_9HIVl|82283124|sp|Q5S348|Q5S348_9HIVl|82283122|sp|Q5S344|Q5S344_9fflVl|82283120|sp|Q5S341|Q5S341_9HIVl|82283118|sp|Q5S337|Q5S337_9HIVl|82283116|sp|Q5S332|Q5S332_9HIVl182283114|sp|Q5S330|Q5S330_9HIVl|82283112|sp|Q5S328|Q5S328_9HIVl|82283110|sp|Q5S323|Q5S323_9HTVl|82283108|sp|Q5S319|Q5S319_9HIVl|82283106|sp|Q5S312|Q5S312_9HIV1|82283104|sp|Q5S307|Q5S307_9HIVl|82283102|sp|Q5S304|Q5S304_9HIVl|82283100|sp|Q5S302|Q5S302_9HTVl|82283098|sp|Q5S2Z9|Q5S2Z9_9HIVl|82283096|sp|Q5S2Z7|Q5S2Z7_9HTVl|82283094|sp|Q5S2Z5|Q5S2Z5_9HTVl|82283092|sp|Q5S2Z0|Q5S2Z0_9HTVl|82283090|sp|Q5S2Y7|Q5S2Y7_9HIVl82283089|sp|Q5S2Y6|Q5S2Y6_9fflVl,

82283087|sp|Q5S2Y4|Q5S2Y4_9HIVl,

82283085|sp|Q5S2Yl|Q5S2Yl_9HIVl,

82283083 |sp|Q5S2X9|Q5S2X9_9HIVl,

82283081|sp|Q5S2X7|Q5S2X7_9HIVl,

82283079|sp|Q5S2X4|Q5S2X4_9HQVl,

82283077|sp|Q5S2X0|Q5S2X0_9fflVl,

82283075|sp|Q5S2W8|Q5S2W8_9EQVl,

82283073|sp|Q5S2W6|Q5S2W6_9HIVl5

82282923 |sp|Q5QCU7|Q5QCU7_9HIVrl,

82282919|sp|Q5QCS9|Q5QCS9_9HIVl,

82282915 |sp|Q5QCRl|Q5QCRl_9HIVl,

82282912|sp|Q5PYP9|Q5PYP9_9HIVl,

82282805|sp|Q5G7F0|Q5G7F0_9HIVl,

82282800|sp|Q5G7C4|Q5G7C4_9HIVl,

82282796|sp|Q5G7A6|Q5G7A6_9HIVl,

82282761 Ísp|Q5G360|Q5G360_9fflVl,

82282759|sp|Q5G358|Q5G358_9fflVl,

82282757jspjQ5G35ójQ5G356_9KTvrl,

82282755|sp|Q5G354|Q5G354_9HIVl,

82282753|sp|Q5G352|Q5G352_9HIVl,

82282751 |sp|Q5G350|Q5G350_9HIVl,

82282749|sp|Q5G348|Q5G348_9HIVl,

82282717|sp|Q5FY37|Q5FY37_9HIVl,

82282712|sp|Q5FY19|Q5FY19_9HIVl,

82282708]sp|Q5FY01|Q5FY01_9HIVl,

82282704|sp|Q5FXY3|Q5FXY3_9fflVl,

82282698|sp|Q5FXW5|Q5FXW5_9HIVl,

82282693|sp|Q5FXU7|Q5FXU7_9HIVl,

82282688 |sp|Q5FXT0|Q5FXT0_9HIVl3

82282684|sp|Q5FXR2|Q5FXR2_9HIVl,

82282680|sp|Q5FXP6|Q5FXP6_9HIVl)

82282574|sp|Q5EEI9|Q5EEI9_9HIVl3

82282570|sp|Q5EEHl |Q5EEH1_9HIV13

82282566|sp|Q5EEF4|Q5EEF4_9HIVl,

82282562|sp|Q5EED6|Q5EED6_9HIVl,

82282558|sp|Q5EEB9|Q5EEB9_9HIVl,

82282554|sp|Q5EEAl |Q5EEA1_9HIV1,

82282550|sp|Q5EE85|Q5EE85_9HTVl3

82282545|sp|Q5EE61|Q5EE61_9HIVl3

82282442|sp|Q5ECR6|Q5ECR6_9HIVl,

82282440|sp|Q5ECR4|Q5ECR4_9HIVl,

82282438|sp|Q5ECR2|Q5ECR2_9HIV 1,

82282436|sp|Q5ECR0|Q5ECR0_9HIVl,

82282434|sp|Q5ECQ8|Q5ECQ8_9HIVl,

82282432|sp|Q5ECQ6|Q5ECQ6_9HIVl3

82282430|sp|Q5ECQ4|Q5ECQ4_9HIVl5

82282428|sp|Q5DJY4|Q5DJY4_9HrVl,

|82283088|sp|Q5S2Y5|Q5S2Y5_9HIVl,|82283086|sp|Q5S2Y2|Q5S2Y2_9HIVl,|82283084|sp|Q5S2Y0|Q5S2Y0_9HTVl,|82283082|sp|Q5S2X8|Q5S2X8_9fflVl3|82283080|sp|Q5S2X6|Q5S2X6_9HIYl,|82283078|sp|Q5S2Xl|Q5S2Xl_9HTVl,|82283076|sp|Q5S2W9|Q5S2W9_9HTVl,|82283074|sp|Q5S2W7|Q5S2W7_9HIVl,|82282925|sp|Q5QCV6|Q5QCV6_9HTVl,|82282921|sp|Q5QCT8|Q5QCT8_9HIVlJ|82282917|sp|Q5QCS0|Q5QCS0_9HTVl,|82282913|sp|Q5PZV3|Q5PZV3_9fflVl,|82282909|sp|Q5PYM3|Q5PYM3_9HIVl,|82282803|sp|Q5G7El|Q5G7El_9fflVl,|82282798|sp|Q5G7B5|Q5G7B5_9HTVl,|82282762|sp|Q5G361|Q5G361_9HTVl,|82282760|sp|Q5G359|Q5G359_9HIVl,|82282758|sp|Q5G357|Q5G357_9HIVl,

innnooifíl__IOfCOfClOtdlCC ΟΙΠΛΠ

ΙΟΛΖ.ΟΖ./jujbpjv^jvjjJ» ■>■>

|82282754|sp|Q5G353|Q5G353_9HrVl,|82282752|sp|Q5G351|Q5G351_9HIVl,|82282750|sp|Q5G349|Q5G349_9HTVl,|82282748|sp|Q5G347|Q5G347_9HIVl,|82282714|sp|Q5FY28|Q5FY28_9HIVl)|82282710|sp|Q5FY10|Q5FY10_9HrVl,|82282706|sp|Q5FXZ2|Q5FXZ2_9HIVl,|82282702|sp|Q5FXX4|Q5FXX4_9HIVl,|82282696|sp|Q5FXV6|Q5FXV6_9HIVl,|82282690|sp|Q5FXT8|Q5FXT8_9HIVl,|82282686|sp]Q5FXSl|Q5FXSl_9HTVl,|82282682|sp|Q5FXQ5|Q5FXQ5_9HIVl,|82282678|sp|Q5FXN7|Q5FXN7_9fflVl,|82282572|sp|Q5EEI0|Q5EEI0_9HTVl,|822825681sp|Q5EEG3|Q5EEG3_9HrVl,182282564|sp |Q5EEE5 |Q5EEE5_9HIV 1,|82282560lsp|Q5EEC8]Q5EEC8_9HTVl,|82282556|sp|Q5EEB0|Q5EEB0_9HIVl,|82282552|sp|Q5EE94|Q5EE94_9HIVl,|82282548]sp|Q5EE77|Q5EE77_9HIVl,|82282543|sp|Q5EE53|Q5EE53_9HIVl,|82282441|sp|Q5ECR5|Q5ECR5_9HIVl,|82282439|sp|Q5ECR3|Q5ECR3_9HIVl,|82282437|sp|Q5ECRl|Q5ECRl_9HTVl,|82282435|sp|Q5ECQ9|Q5ECQ9_9HIVl,|82282433|sp|Q5ECQ7|Q5ECQ7_9HIVl,|8228243 l|sp|Q5ECQ5|Q5ECQ5_9HIVl,|82282429|sp|Q5ECQ3|Q5ECQ3_9HIVl,|82282427|sp|Q5DJY3|Q5DJY3_9HTVl,82282426|sp|Q5DJY0|Q5DJY0_9HIVl,

82282424|sp|Q5DJX8|Q5DJX8_9HIVl,

82282422|sp|Q5DJX6|Q5DJX6_9HIVl,

82282420|sp|Q5DJX4|Q5DJX4_9fflVls

82282418|sp|Q5DJX2|Q5DJX2_9fflVl,

82282416|sp|Q5DJX0|Q5DJX0_9HIVl,

82282414|sp|Q5DJW8|Q5DJW8_9HIVl,

82282412|sp|Q5DJW6|Q5DJW6_9HIVlJ

82282410|sp|Q5DJW4|Q5DJW4_9fflVl3

82282408|sp|Q5DJW2|Q5DJW2_9HIVl,

82282406|sp|Q5DJW0|Q5DJW0_9HIVl,

82282404|sp|Q5D577|Q5D577_9HIVl,

82282402|sp|Q5D575|Q5D575_9HIVl,

82282400|sp|Q5D573|Q5D573_9HIVl,

82282398|sp|Q5D571|Q5D571_9HIVl,

82282396|sp|Q5D565|Q5D565_9HIVl,

82282394|sp|Q5D563|Q5D563_9HIVl,

82282392|sp]Q5D560|Q5D560_9HIVl,

82282390|sp|Q5D557|Q5D557_9HIVl,

82282388|sp|Q5D553|Q5D553_9HIVl,

82282386|sp|Q5D551 |Q5D551_9HIV1,

82282384|sp|Q5D548|Q5D548_9HIVl,

822823 82|sp|Q5D545 |Q5D545_9HIV1,

82282380|sp|Q5D543|Q5D543_9HIVl5

82282378|sp|Q5D540|Q5D540_9HrV,l,

82282376|sp|Q5D538|Q5D538_9HIVl,

82282374|sp|Q5D536|Q5D536_9HIVl,

82282372|sp|Q5D534|Q5D534_9HIVl,

82282370|sp|Q5D532|Q5D532_9HIVl,

82282368 |sp|Q5D530|Q5D530_9HIVl5

82282366|sp|Q5D528|Q5D528_9HIVl,

82282364|sp|Q5D526|Q5D526_9HIVl,

82281862|sp|Q5MC93|Q5MC93_9HIVl,

82281860|sp|Q5MC91 |Q5MC91_9HIV1,

82281858|sp|Q5MC89|Q5MC89_9HIVl,

82281855|sp|Q5MC87|Q5MC87_9HIVl,

82281853 |sp|Q5MC85|Q5MC85_9HIVl,

82281851 |sp|Q5MC83|Q5MC83_9HIVl,

82281849|sp|Q5MC81 |Q5MC81_9HIV1,

82281847|sp|Q5MC79|Q5MC79_9HTVl,

82281844|sp|Q5MC77|Q5MC77_9HIVl,

82281841 |sp|Q5MC75 |Q5MC75_9HIV1,

82281839|sp|Q5MC73|Q5MC73_9HIVl,

82281837|sp|Q5MC71|Q5MC71_9HTVl5

82281835 |sp|Q5MC69 |Q5MC69_9HIV1,

82281833 |sp|Q5MC67|Q5MC67_9HIVl,

8228183 l|sp|Q5MC65|Q5MC65_9HIVl,

82281828|sp|Q5MC63|Q5MC63_9fflVl,

|82282425|sp|Q5DJX9|Q5DJX9_9HIVl|82282423 |sp|Q5DJX7|Q5DJX7_9ffiVl|82282421 |sp|Q5DJX5 |Q5DJX5_9HIV1|82282419|sp|Q5DJX3|Q5DJX3_9HIVl|82282417|sp|Q5DJXl|Q5DJXl_9mVl|82282415|sp|Q5DJW9|Q5DJW9_9fflVl|82282413|sp|Q5DJW7|Q5DJW7_9HIVl|82282411 |sp|Q5DJW5|Q5DJW5_9HIVl|82282409|sp|Q5DJW3|Q5DJW3_9HIVl|82282407|sp|Q5DJWl|Q5DJWl_9HIVl|82282405 |spiQ5DJV9|Q5DJV9_9HIVl|82282403|sp|Q5D576|Q5D576_9HIVl|82282401|sp|Q5D574|Q5D574_9HrVl|82282399|sp|Q5D572|Q5D572_9HIVl|82282397|sp|Q5D570|Q5D570_9HTVl|82282395|sp|Q5D564|Q5D564_9HIVl|82282393 |sp|Q5D561|Q5D561_9mVl|82282391|sp|Q5D558|Q5D558_9HIVl|82282389|sp|Q5D555jQ5D555_9HIVl|82282387|sp|Q5D552|Q5D552_9HIVl|82282385|sp|Q5D550|Q5D550_9HIVl|82282383|sp|Q5D546|Q5D546_9HIVl|82282381 |sp|Q5D544|Q5D544_9HIVl|82282379|sp|Q5D542|Q5D542_9HIVl|82282377|sp|Q5D539|Q5D539_9HIVl]82282375|sp|Q5D537|Q5D537_9HIVl|82282373|sp|Q5D535|Q5D535_9HIVl|82282371 |sp|Q5D533|Q5D533_9HIVl|82282369|sp|Q5D531 |Q5D531_9HIV1|82282367|sp|Q5D529|Q5D529_9HIVl|82282365|sp|Q5D527|Q5D527_9HIVl|82281946|sp|Q5MJ71|Q5MJ71_9HIVl|82281861 |sp|Q5MC92|Q5MC92_9HIVl|82281859|sp|Q5MC90|Q5MC90_9HIVl|82281856|sp|Q5MC88|Q5MC88_9HIVl|82281854|sp|Q5MC86|Q5MC86_9HIVl|82281852|sp|Q5MC84]Q5MC84_9HIVl|82281850|sp|Q5MC82|Q5MC82_9HrVl|82281848|sp|Q5MC80|Q5MC80_9HIVl|82281846|sp|Q5MC78|Q5MC78_9fflVl|82281843|sp|Q5MC76|Q5MC76_9HIVl|82281840|sp|Q5MC74|Q5MC74_9HIVl|82281838|sp|Q5MC72|Q5MC72_9HIVl|82281836|sp|Q5MC70|Q5MC70_9HIVl|82281834|sp|Q5MC68|Q5MC68_9HIVl|82281832|sp|Q5MC66|Q5MC66_9HIVl|82281829|sp|Q5MC64|Q5MC64_9HIVl|82281827|sp IQ5MC62 |Q5MC62_9HTV82281826|sp|Q5MC61|Q5MC61_9HIVl,82281824|sp|Q5MC59|Q5MC59_9HIVl,82281822|sp|Q5MC57|Q5MC57_9HrVl,82281820|sp|Q5MC55|Q5MC55_9HIVl,82281817|sp|Q5MC53|Q5MC53_9fflVl,82281815|sp|Q5MC51 |Q5MC51_9HIV1,82281813|sp|Q5MC49|Q5MC49_9HIVl,82281811 jsp |Q5MC47 |Q5MC47_9HTV 1,82281809|sp|Q5MC45|Q5MC45_9HTVl,82281806|sp|Q5MC43 |Q5MC43_9fflVl,82281804|sp|Q5MC40|Q5MC40_9HIVl,82281802|sp|Q5MC38|Q5MC38_9HIVl,82281800|sp|Q5MC36|Q5MC36_9BQYl,82281798|sp|Q5MC34|Q5MC34_9fflVl,82281795|sp|Q5MC32|Q5MC32_9HIVl,82281793|sp|Q5MC30|Q5MC30_9ffiVl,82281791 jsp|Q5MC28|Q5MC28_9HIVl,82281789|sp|Q5MC26|Q5MC26_9HIVl,

οΛΛοηοιίΐ___i/^fn ίΠΛ ΛίΓιη Í/vi /i ΛΤΤΤΧΠ

Oi^Oi ν χ,

82281784|sp|Q5MC22|Q5MC22_9HIVl,82281782|sp|Q5MC20|Q5MC20_9HIVl,82281780]sp|Q5MC18|Q5MC18_9HIVl,82281778|sp|Q5MC16|Q5MC16_9HIVl,82281775|sp|Q5MC14|Q5MC14_9HIVl,82281773|sp|Q5MC12|Q5MC12_9HIVl,82281771 |sp|Q5MC 10|Q5MC10_9HIV1,82281769|sp|Q5MC08|Q5MC08_9HIVl,82281767|sp|Q5MC06|Q5MC06_9HIVl,82281764|sp|Q5MC04|Q5MC04_9HIVl,82281762|sp|Q5MC02|Q5MC02_9HIVl,82281760|sp|Q5MC00|Q5MC00_9HIVl,8228175 8 |sp|Q5MBZ8 |Q5MBZ8_9HIV1,82281756|sp|Q5MBZ6|Q5MBZ6_9HIVl,82281754|sp|Q5MBZ4|Q5MBZ4_9HIVl,82281752|sp|Q5MBZ2|Q5MBZ2_9HIVl,82281750|sp|Q5MBZ0|Q5MBZ0_9HIVl,82281748|sp|Q5MBY8|Q5MBY8_9HIVl,82281746|sp|Q5MBY6|Q5MBY6_9HIVl,82281744|sp|Q5MBY4|Q5MBY4_9HIVl,82281741 |sp|Q5MBY2|Q5MBY2_9HIVl,82281739|sp|Q5MBY0|Q5MBY0_9HrVl,82281737|sp|Q5MBX8|Q5MBX8_9HIVl,82281735|sp|Q5MBD6|Q5MBD6_9fflVl,82281733 |sp|Q5MBD4|Q5MBD4_9mVl,82281731 |sp|Q5MBD2|Q5MBD2_9fflVl,82281729|sp|Q5MBD0|Q5MBD0_9HIVl,82281727|sp|Q5MBC8|Q5MBC8_9HIVl,82281725|sp|Q5MBC6|Q5MBC6_9HIVl,

|82281825|sp|Q5MC60|Q5MC60_9HTVl,

|82281823|sp|Q5MC58|Q5MC58_9HIVl,

|82281821 |sp|Q5MC56|Q5MC56_9HIVl,

|82281818|sp|Q5MC54|Q5MC54_9HIVl,

|82281816|sp|Q5MC52|Q5MC52_9HIVl,

|82281814|sp|Q5MC50|Q5MC50_9HIVl,

|82281812|sp|Q5MC48|Q5MC48_9HIVl,

|82281810|sp|Q5MC46|Q5MC46_9HIVl,

|82281807|splQ5MC44|Q5MC44_9HIVl,

|82281805|sp|Q5MC42|Q5MC42_9HIVl,

|82281803|sp|Q5MC39|Q5MC39_9HIVl,

|82281801|sp|Q5MC37|Q5MC37_9HIVl,

|82281799|sp|Q5MC35|Q5MC35_9fflVl,

|82281796|sp|Q5MC33 |Q5MC33_9HIV1,

|82281794|sp|Q5MC31 |Q5MC31_9HIV1,

|82281792|sp|Q5MC29|Q5MC29_9fflVl,

|82281790|sp|Q5MC27|Q5MC27_9HIVl,

|82281787|sp|Q5MC25 |Q5MC25_9HIV1,10ΛΛ01 nocu-J/^cA/rr^ooiriCN/rr^oa ΟΙΤΤΛΠ

[ΟώΛΟΙ I O-/ jo^/j _/AJJ-' ■»■>

|82281783 |sp|Q5MC21 |Q5MC21_9HIV1,|82281781|sp|Q5MC19|Q5MC19_9HIVl,|82281779|sp|Q5MC17|Q5MC17_9inVl,|82281776|sp|Q5MC15|Q5MC15_9HIVl,|82281774|sp|Q5MC13|Q5MC13_9HTVl,|82281772|sp|Q5MCll|Q5MCll_9mVl,|82281770|sp|Q5MC09|Q5MC09_9fflVl,|82281768 |sp|Q5MC07|Q5MC07_9HIV 1,|82281766|sp|Q5MC05|Q5MC05_9HIVl,|822817631sp|Q5MC03 |Q5MC03_9HTV 1,|82281761 |sp|Q5MC01 |Q5MC01_9HIV1,|82281759|sp|Q5MBZ9|Q5MBZ9_9HIVl,|82281757|sp|Q5MBZ7|Q5MBZ7_9HTVl,|82281755|sp|Q5MBZ5|Q5MBZ5_9HTVl,|82281753 |sp|Q5MBZ3 |Q5MBZ3_9HTV1,|82281751|sp|Q5MBZl|Q5MBZl_9HIVl,|82281749|sp|Q5MBY9|Q5MBY9_9HIVl,|82281747|sp|Q5MBY7|Q5MBY7_9HIVl,|82281745 |sp|Q5MBY5 |Q5MBY5_9HIV1,|82281742|sp|Q5MBY3|Q5MBY3_9HIVl,|82281740|sp|Q5MBYl|Q5MBYl_9HIVl,|82281738|sp|Q5MBX9|Q5MBX9_9HIVl,|82281736|sp|Q5MBD7|Q5MBD7_9HIVl,|82281734|sp|Q5MBD5|Q5MBD5_9HIVl,|82281732|sp|Q5MBD3|Q5MBD3_9fflVl,|82281730|sp|Q5MBDl|Q5MBDl_9HIVl,|82281728|sp|Q5MBC9|Q5MBC9_9HIVl,|82281726|sp|Q5MBC7|Q5MBC7_9HIVl5182281724|sp|Q5MBC5|Q5MBC5_9HIVl,82281722|sp|Q5MBC4|Q5MBC4_9HIVl,82281720|sp|Q5MBC2|Q5MBC2_9HIVl,82281718|sp|Q5MBC0|Q5MBC0_9H[Vl,82281716|sp|Q5MBB8|Q5MBB8_9HIVl,82281714|sp|Q5MBB6|Q5MBB6_9HIVl,82281712|sp|Q5MBB4|Q5MBB4_9mVl,82281203|sp|093204|093204_9HIVl,82281155|sp|092887|092887_9HIVl382280765|sp|091186|091186_9HIV182280763]sp|091184|091184_9HIV182280740|sp|091078|091078_9HIVl82280738|sp|091076|091076_9HIVl82280736|sp|091074|091074_9HIVl82280734|sp|091072|091072_9HIVl82280732|sp|091070|091070_9HIVl82280730|sp|0910681091068_9HIV182280728|sp|091066|091066_9EDYl82280726|sp|091064|091064_9fflVl

0100Λ70/ΙΙ«-ΙΑΛ1 Λ^ΟΙΓΛΓΜ A/TO ΛΤΤΠ TΛ/ i. iuu^_?ιιιν JL

82280722|sp|091060|091060_9HIVl82280720|sp|091058|091058_9HIVl82280718|sp|091056|091056_9HIVl82280716|sp |091054|091054_9HIV182280714|sp|091052|091052_9HIVl82280712|sp|091050|091050_9HIVl82280710|sp|0910481091048_9HIV182280708|sp|091046|091046_9HIVl82280706|sp|091044|091044_9HIVl82279832|sp]070680|070680_9HIVl82279580|sp|040521|040521_9HIVl82279578|sp|040519|040519_9HIVl82279576|sp|040517|040517_9HIVl82279528|sp|040367|040367_9HIVl82279526|sp|040363|040363_9HIVl82279524|sp|040361|040361_9HIVl82279522|sp|040358|040358_9HIVl82279466|sp|040178|040178_9HIVl78172857|gb|ABB29388.1|,78172825 |gb|ABB29359.11,55275264|gb|AAV49476.1|,55275234|gb|AAV49449.1 j,55275204|gb|AAV49422.1|,55275174|gb|AAV49395.1 j,55275144|gb|AAV49368.1|,73914001|gb|AAZ91961.1|,73913939|gb|AAZ91906.1|,73913910|gb|AAZ91880.1|,

73913881 |gb|AAZ91854.11 trancada,

|78172847|gb| ABB29379.1|78172819|gb|ABB29354.1|55275254|gb|AAV49467.1|55275224|gb|AAV49440.1|55275194|gb|AAV49413.1|55275164|gb|AAV49386.1|55275134|gb|AAV49359.1|73913983 |gb | AAZ91945.1|73913929|gb|AAZ91897.1|73913900|gb|AAZ91871.1

182281721 |sp|Q5MBC3|Q5MBC3_9HIVl,|82281719|sp|Q5MBCl|Q5MBCl_9HIVl3|82281717|sp|Q5MBB9|Q5MBB9_9HIV 1,|82281715 |sp|Q5MBB7|Q5MBB7_9HIVl,|82281713|spiQ5MBB5|Q5MBB5_9HIVl,|82281236|sp|P87925|P87925_9HIVl,|82281180|sp|093025|093025_9ffiVl3|82281072|sp|092593|092593_9HIVl,|82280764|sp|0911851091185_9HTV1,|82280762|sp|091183|091183_9fflVl,|82280739|sp|091077|091077_9HTVl,|82280737|sp|0910751091075_9HIV 1,|82280735|sp|091073|091073_9HIVl5|82280733|sp|091071|091071_9fflVl3|82280731 |sp|091069|091069_9HIV1,|82280729|sp|091067|Ò91067_9mVl,|82280727|sp|091065|091065_9HIVl,182280725 |sp|0910631091063_9HIV 1,

ΙΟΟΟΟΛαοΟί^ΙΓΛΠΙ fUZ 1 Ι/Λ01 f\C 1 OUTl M

V / ιυυι j w-/ ± \s\j χ yi-u. τ χ?

|82280721 |sp|091059|091059_9HIVl3|82280719|sp|091057|091057_9HIVl3|82280717|sp|091055|091055_9HIVl,|82280715|sp|091053|091053_9ffiVl3|82280713|sp|091051|091051_9HIVl3|82280711 |sp|091049|091049_9HIV 1,|82280709|sp|091047|091047_9mvi3|82280707|sp|091045|091045_9HIVl3|82279882|sp|071256|071256_9HIVl,|82279581|sp|040522|040522_9HIVl,|82279579|sp|040520|040520_9HIVl,|82279577|sp|040518|040518_9fflVl,|82279575|sp|040516|040516_9HIVl,|82279527|sp|040365|040365_9HIVl3|82279525 |sp|040362|040362_9HIVl3|82279523|sp|040359|040359_9HrVl,|82279479|sp|040223|040223_9HrVl,|82279465 |sp|040177|040177_9HIV 1,|78172837|gb|ABB29370.1|,|63081185|gb|AAY30347.1|,|55275244|gb|AAV49458.1|,|55275214|gb|AAV49431.1|,|55275184|gb| AAV49404.1 j,|55275154|gb|AAV49377.1|,|55275124|gb|AAV49350.1|,|73913973|gb|AAZ91936.1|,|73913919|gb|AAZ91888.1|,|73913890|gb|AAZ91862.1|3|73913871|gb|AAZ91845.1|,73913861 |gb|AAZ91836.11,7391383 l|gb|AAZ91809.1|,73913802|gb|AAZ91783.1|,73913782|gb|AAZ91765.1 j tnmcada

|73913 851 |gb|AAZ91827.1|,|73913821|gb|AAZ91800.1|,

73913762|gb|AAZ91747.1|,37681539|gb|AAQ97649.1|,37677902|gb|AAQ97568.1|,37677872|gb|AAQ97541.1|,37677832|gb|AAQ97505.1|,37677802|gb|AAQ97478.1|,37677772|gb|AAQ97451.1],71794631 |emb|CAI28870.11,71794602|emb|CAI28843.1|,57901115 |gb| AAW57879.157901077|gb|AAW57845.1|,58221035|gb|AAW68210.1|,58221007|gb|AAW68185.1|,

|46243172|gb|AAS83698.1|,|37681549|gb|AAQ97658.1|,|37677892|gb|AAQ97559.1j,|37677862|gb|AAQ97532.1|,l37677822lgbjAAQ97496.il,|37677791 |gb|AAQ97468.1 j,|37677762|gb|AAQ97442.1|,|71794621|emb|CAI28861.1|,|71794593|emb|CAI28834.1|,|57901106|gb|AAW57871.1|,|57901066|gb|AAW57835.1|,|58221025|gb|AAW68201.1|,|58220997|gb|AAW68176.1|,

|73913841|gb|AAZ91818.1|,|73913811|gb|AAZ91791.1|,l73913792lgblAAZ91774.ll,|73913772|gb|AAZ91756.1|,|46243158|gb|AAS83685.1|,|37677912|gb|AAQ97577.1|37677882|gb|AAQ97550.1|,|37677842|gb|AAQ97514.11,1376778 ll|gb|AAQ97486.1|,|37677782|gb|AAQ97460.11,|62361775|gb|AAX81423.1|,|7179461 l|emb|CAI28852.1|,|71794583|emb|CAI28825.1|,|57901096|gb|AAW57862.1|,|58221045|gb|AAW68219.1|,|58221015|gb|AAW68192.1|,|58220987|gb|AAW68167.1|,

58220978|gb|AAW68159.11, |58220968|gb|AAW68150.1|, |58220958|gb|AAW68141.1|,

COOIAA/JOI-LI λ AnrroiIO 11jo^-z-u^^toi^uii-wn. VV UO IDZ.. χ j,

58220918|gb|AAW68105.1|,

58220888|gb|AAW68078.1|,

38892790|gb|AAR27780.1|,

38892762|gb|AAR27755.11,

38892734|gb|AAR27730.1|,

38892706|gb|AAR27705.1|,

38892678|gb|AAR27680.1|,

3889265 l|gb|AAR27656.1|,

38892626|gb|AAR27634.1|,

55139356jgblAAV41369.il,

55139326|gb|AAV41342.1|,

55139306|gb|AAV41325.1|,

551392771gb|AAV41299.1|,

68522161 |gb|AAY98746.11,

68522132|gb|AAY98720.1|,

68522102|gb|AAY98693.1|,

68522072|gb| AAY98666.11,

68522042|gb|AAY98639.1|,

68522012|gb|AAY98612.1|,

68521982|gb|AAY98585.1|,

68521952|gb|AAY98558.1|,

67553109|gb|AAY68695.1|,

67553079|gb|AAY68668.1|,

67553049|gb|AAY68641.1|,

67553004|gb|AAY68601.11,

66473535|gb|AAY46415.1|,

55416513 |gb| AAV50220.11,

55416507|gb|AAV50217.1|,

55416501 |gb|AAV50214.1|,

ICOTinniOl-I-U »nríom 11vv uu —j. j,

|5 8220908|gb| AAW68096.11,|58220878|gb|AAW68069.1|,|38892781 |gb|AAR27772.11,|38892752|gb|AAR27746.1|,|38892724|gb| AAR27721.11,|38892696|gb|AAR27696.1|,|38892669|gb|AAR27672.11,|38892643|gb|AAR27649.1|,|38892617|gb|AAR27626.1|,|55139347|gb|AAV41361.1|,|55139319|gb|AAV41336.1|,|55139297|gb|AAV41317.1|,|55139268|gb|AAV41291.1|,|68522151 |gb|AAY98737.11,|68522122|gb| AAY98711.11,|68522092|gb| AAY98684.1 j,|68522062|gb|AAY98657.1|,|68522032|gb|AAY98630.1|,|68522002|gb|AAY98603.1|,|68521972]gb|AAY98576.1|,|68521942|gb|AAY98549.1|,|67553099|gb|AAY68686.1|,|67553069|gb|AAY68659.1|,|67553039|gb|AAY68632.1|,|67552994|gb| AAY68592.11,|55416517|gb|AAV50222.1|,|55416511|gb|AAV50219.1|,Í55416505|gb|AAV50216.1|,|55416499|gb|AAV50213.1|,

iconnnmol^ulA AW/CB11/I 11

I U U.?-^ujguj Z-JO-L TT WWi x-r.xj,

|58220898|gb|AAW68087.1|,|58220868|gb|AAW68060.1|,|3 8892771 |gb| AAR27763.11,|38892744|gb|AAR27739.1|,|38892714|gb|AAR27712.1|,|38892687|gb|AAR27688.1|,|38892662|gb|AAR27666.1 j,|38892634|gb|AAR27641.1|,|38892607|gb|AAR27617.1|,|55139336|gb|AAV41351.1|,|55139315|gb|AAV41333.1|,|55139286|gb|AAV41307.1|,|55139260|gb|AAV41284.1|,|68522142|gb|AAY98729.1|,|68522112|gb|AAY98702.1|,|68522082|gb|AAY98675.1|,|68522052|gb|AAY98648.1|,|68522022|gb|AAY98621.11,|68521992|gb|AAY98594.1|,|68521962|gb|AAY98567.1|,|67553119|gb|AAY68704.1|,|67553089|gb|AAY68677.11,|67553059|gb|AAY68650.1|,|67553029|gb| AAY68623.11,|67552984|gb|AAY68583.1|,|55416515|gb|AAV50221.1|,|55416509|gb|AAV50218.1|,|55416503|gb|AAV50215.1|,|55416497|gb|AAV50212.1|,|55416495|gb|AAV50211.1|, |55416493|gb|AAV50210.1|,|55416489|gb|AAV50208.1|,|55416485|gb|AAV50206.1 Itnmcada,|55416481 |gb|AAV50204.1 j, |55416479|gb|AAV50203.1|55416475|gb|AAV50201.1 j, |55416473 |gb|AAV50200.1 j,|55416469|gb|AAV50198.1 jtnmcada,

|55416465|gb|AAV50196.1|,|55416459|gb|AAV50193.1|,l55416453lgblAAV50190.ll,|55416447|gb|AAV50187.1|,|55416441 |gb|AAV50184.11,|55416435|gb|AAV50181.1|,|55416429|gb|AAV50178.1|,|55416423|gb|AAV50175.1|,

|55416463|gb|AAV50195.1|,|55416457|gb|AAV50192.1|,|5541645ljgb|AAV50189.1|,|55416445|gb|AAV50186.1|,|55416439|gb|AAV50183.1|,l55416433lgblAAV50180.ll,l55416427lgblAAV50177.ll,|55416421|gb|AAV50174.1|,

|55416417|gb|AAV50172.1|,|63098428|gb|AAY32467.1 jtnmcada,|63098408|gb|AAY32449.1 j, |63098398|gb|AAY32440.1|,|63098378|gb|AAY32422.1j, |63098369|gb|AAY32414.11,

I--------IO-I-----------U

|63098331 |gb|AAY32380.1 |tnmcada,

]63098312|gb|AAY32363.1|, |63098303|gb|AAY32355.1|,

|56609344|gb|AAW03294.11,|56609307|gb|AAW03262.1 j,|56609277|gb|AAW03235.1|,|56609247|gb|AAW03208.1 j,|3413755|emb|CAA76922.1|,|3413749|emb|CAA76919.1|,|3413743|emb|CAA76916.1|,|60200|emb|CAA77629.11,|37496496|emb|CAD48453.11,|32399664|emb|CAD58642.11,118073407|emb|CAC87998.11,|14041634|emb|CAC38437.1|,|7657897|emb|CAB89151.11,|7321152|emb|CAB82234.1 j,|4539057|emb|CAB39746.11,|59895877|gb|AAXl 1318.11,|59895870|gb|AAXl 1315.1 j,|59895860|gb|AAXl 1312.1|,j59895854|gb|AAXl 1309.11,|59895847|gb|AAXl 1306.11,|59895841|gb|AAX11303.1|,|59895834|gb|AAXl 1300.11,|59895 827|gb|AAXl 1297.11,|59895 821 jgb|AAXl 1294.11,j59895815jgbjAAX11291.lj,Í59895807jgbjAAX11288.lj,|59895801 jgbjAAXl 1285.1|,

|56609333 |gb|AAW03285.1|,Í56609297|gbjAAW03253.1|,l56609267lgbjAAW03226.il,|3417244|emb|CAA76913.11,|3413753|emb|CAA76921.1|,Í3413747jembjcAA76918.lj,|3413741 jembjcAA76915.lj,|3163938|emb|CAA06954.1|,|37496488|emb|CAD48446.11,|18074007|emb|CAC86572.1 j,115209258|emb|CAC51037.11,|9368387Íemb|CAB98176.lj,|7452917|emb)CAB86382.1|,|7321142jembjcAB82225.lj,|4539042|emb|CAB39924.11,Í59895875|gb|AAX11317.1|,Í59895868jgb|AAXl 1314.1 j,|59895858|gb|AAXl 1311.1|,|59895852|gb|AAXl 1308.1|,|59895845 |gb|AAXl 1305.1],|59895838|gb|AAXl 1302.11,|59895832|gb|AAXl 1299.11,|59895825|gb|AAX11296.1|,|59895819|gb|AAX11293.1|,|59895813 |gb| AAXl 1290.11,|59895805jgb|AAX11287.1|,|59895799|gb|AAXl 1284.11,

|55416491|gb|AAV50209.1||55416487|gb|AAV50207.1||55416483 |gb|AAV50205.11|55416477|gb|AAV50202.1||55416471|gb|AAV50199.1||55416467|gb|AAV50197.1||55416461|gb|AAV50194.1||55416455|gb|AAV50191.lj|55416449|gb|AAV50188.1||55416443|gb|AAV50185.1||55416437|gb|AAV50182.1||55416431|gb|AAV50179.1||55416425|gb|AAV50176.1||55416419|gb|AAV50173.1||63098438|gb|AAY32476.11|63098418|gb|AAY32458.1|1630983 88|gb|AAY32431.11|63098360|gb|AAY32406.1|

!«nQei/IIUUA AVMlOO 11

jw^U^ UJTl i Ji juy. 1 I

|63098321 |gb|AAY32371.11163098293 |gb|AAY32346.11|56609317|gb|AAW03271.11|56609287|gb|AAW03244.1 j|56609257|gb|AAW03217.1 j|3417242|emb|CAA76912.1||3413751 |emb|CAA76920.1 j|3413745|emb|CAA76917.1||3413739|emb|CAA76914.11|37496504|emb|CAD48460.1||32399672|emb|CAD58651.1||18073417|emb|CAC88007.1||14041644|emb|CAC38428.1||9368377|emb|CAB98194.1||7452907|emb|CAB86373.11|5738574|emb|CAB53050.1||59895879|gb|AAX11319.1||59895873|gb|AAX11316.1||59895864|gb|AAX11313.1||59895856|gb|AAXl 1310.11|59895849|gb|AAXl 1307.1||59895843|gb|AAX11304.1||59895836|gb|AAXl 1301.11|59895829|gb|AAXl 1298.1||59895823|gb|AAXl 1295.1||59895817|gb|AAXl 1292.1||59895811|gb|AAXl 1289.11|59895803|gb|AAXl 1286.11|59895797|gb|AAXl 1283.11|59895795|gb|AAXl 1282.1|59895789|gb|AAXl 1279.1|59895783|gb|AAXl 1276.1|59895774|gb|AAXl 1273.1|59895768|gb|AAXl 1270.1|59003675|gb|AAW83670.1|59003655|gb|AAW83652.|59003635|gb|AAW83634.1|59003606|gb|AAW83608.1|59003576|gb|AAW83581.1|59003546|gb|AAW83554.1|59003516|gb|AAW83527.1|57904558|gb|AAW58814.1|57904552|gb|AAW58811.1|57904544|gb|AAW58808.1|57904537|gb|AAW58805.1157904531 |gb|AAW58802.1|57338570|gb|AAW49364.1

Ic709oc/nl~t-l Λ Aiir/n·?/

|_< / JJOJt / VV

|56609035|gb|AAW03148.|56609029|gb|AAW03145.|56609022|gb|AAW03142.1|56609016|gb|AAW03139.1|56609010]gb|AAW03136.1|56609004]gb|AAW03133.1|56608998|gb|AAW03130.1|56608992|gb|AAW03127.1|56608986|gb| AAW03124.1|56608980|gb|AAW03121.|56608974|gb|AAW03118.1|56608968|gb|AAW03115.1|56608962|gb|AAW03112.1|56608956|gb|AAW03109.1|56608950|gb|AAW03106.1|56608944|gb|AAW03103.1|56608938|gb|AAW03100.1|56608932|gb|AAW03097.1|56608926|gb|AAW03094.1|56608920|gb|AAW03091.1|56608914|gb|AAW03088.1|56608908|gb|AAW03085.1|56608902|gb|AAW03082.1|56608896|gb|AAW03079.1|56608890|gb|AAW03076.1|56608884|gb|AAW03073.1|56608878|gb|AAW03070.1]56608872|gb|AAW03067.1|56608866|gb|AAW03064.1

|59895793 |gb|AAXl 1281.1|,|59895787|gb|AAXl 1278.1|59895778|gb|AAXl 1275.1|,|59895772|gb|AAXl 1272.11,|59895766|gb|AAXl 1269.11,

l|tnmcada,

|59003625|gb|AAW83625.1|,|59003596|gb|AAW83599.1|5|59003566|gb|AAW83572.1 j,|59003536|gb|AAW83545.1|,|45738228|gb|AAS75886.1|,|57904556|gb|AAW58813.1|,|57904548|gb|AAW58810.1|,|57904542|gb|AAW58807.1|,|57904535|gb|AAW58804.1|,|57904529|gb|AAW58801.11,

|57338561|gb|AAW49356.1|,

IcrinnninuulA uimiun 11

|56609033|gb|AAW03147.1|,|56609026|gb|AAW03144.11,|56609020|gb]AAW03141.1|,|56609014|gb|AAW03138.1|,|56609008|gb|AAW03135.1|,|56609002|gb|AAW03132.11,|56608996|gb| AAW03129.1 j,|56608990|gb| AAW03126.1 j,|56608984|gb|AAW03123.1|,|56608978|gb|AAW03120.1|,|56608972|gb|AAW03117.1|,|56608966|gb|AAW03114.1|,|56608960|gb| AAW03111.11,|56608954]gb|AAW03108.1|,|56608948|gb|AAW03105.1|,|56608942|gb|AAW03102.1|,|56608936|gb|AAW03099.1|,|56608930]gb|AAW03096.1|,|56608924|gb|AAW03093.1|,|56608918|gb|AAW03090.1|,|56608912|gb|AAW03087.1|,|56608906|gb|AAW03084.1|,|56608900|gb| AAW03081.11,|56608894|gb|AAW03078.1|,|56608888|gb|AAW03075.11,|56608882|gb|AAW03072.1|,|56608876|gb|AAW03069.1|,|56608870|gb|AAW03066.1|,|56608864|gb|AAW03063.1|,

|59895791|gb|AAXl 1280.1|,|59895785|gb|AAXl 1277.1|,|59895776|gb|AAXl 1274.1|,|59895770|gb|AAX11271.1|,|59895764|gb|AAXl 1268.1|,|59003665|gb|AAW83661.1 j,|59003645|gb|AAW83643.1|,|59003616|gb|AAW83617.1 j,|59003586|gb|AAW83590.1|,|59003556|gb|AAW83563.1|,|59003526|gb|AAW83536.1|,|45738218|gb|AAS75877.11,|57904554|gb|AAW58812.1|,|57904546|gb|AAW58809.1|,|57904540|gb| AAW5 8806.11,|57904533|gb|AAW58803.1|,|57904527|gb|AAW58800.1|,|57338554|gb|AAW49350.1|,

ic/ccnonnUKi Λ AAurmi/io 11

|56609031|gb|AAW03146.1|,

|56609024|gb| AAW03143.1 j,

|56609018|gb|AAW03140.1|,

|56609012|gb|AAW03137.11,

|56609006]gb|AAW03134.1 j,

|56609000|gb| AAW03131.11,

|56608994|gb|AAW03128.1|,

|56608988|gb|AAW03125.1|,

|56608982|gb|AAW03122.11,

|56608976|gb|AAW03119.11,

|56608970|gb|AAW03116.1|,

|56608964|gb|AAW03113.1|,

|56608958|gb|AAW03110.11,

|56608952|gb|AAW03107.11,

|56608946|gb|AAW03104.1|,

|56608940|gb|AAW03101.1 j,

|56608934|gb|AAW03098.1|,

|56608928|gb|AAW03095.1|,

|56608922|gb|AAW03092.1|,

|56608916|gb|AAW03089.1|,

|56608910|gb|AAW03086.11,

|56608904|gb|AAW03083.1|,

|56608898|gb|AAW03080.1|,

|56608892|gb|AAW03077.1|,

|56608886|gb|AAW03074.1|,

|56608880|gb|AAW03071.1|,

|56608874|gb|AAW03068.1|,

|56608868|gb|AAW03065.1|,

|56608862|gb|AAW03062.1|,56608860|gb| AAW03061.il,56608854lgbjAAW03058.il,56608848lgblAAW03055.ll,56608842|gb|AAW03052.11,56608836|gb|AAW03049.1|,56608830|gb|AAW03046.1|,56608824lgbjAAW03043.il,56608818jgbjAAW03040.lt56608812|gb|AAW03037.1|,55925143|gb|AAV67947.11,55925119|gb|AAV67926.1|,51572111|gb|AAU06760.1|,49472956|gb|AAT66298.1|,49472930|gb|AAT66275.1 j,37682587|gb|AAQ98269.1|,37682558|gb|AAQ98243.1|,37682528|gb|AAQ98216.1|,|37682498|gb|AAQ98189.1 j,137682469'gb1 AAQ98163.11,Í37682449Ígb|AAQ98145.11tnmcada,|37682429|gb|AAQ98127.1|, |37682418|gb|AAQ98117.1],

|56608858|gb|AAW03060.1|,|56608852|gb|AAW03057.1|,|56608846|gb|AAW03054.1|,|56608840|gb|AAW03051.1|,|56608834|gb|AAW03048.1|,|56608828|gb|AAW03045.1|,|56608822|gb|AAW03042.1|,|56608816|gb|AAW03039.1|,156608810|gb|AAW03036.1|,|55925135|gb|AAV67940.1|,|51572130|gb|AAU06777.1|,|51572102|gb| AAU06752.11,|49472947|gb| AAT66290.11,|37682607|gb|AAQ98287.11,|37682577|gb|AAQ98260.1|,137682548 |gb|AAQ98234.11,|37682518 |gb|AAQ98207.11,|37682489 |gb|AAQ98181.1 j,

46486662|gb|AAS98766.1|,46486633|gb|AAS98740.11,46254412|gb|AAS86171.1|,38679139|gb|AAR26394.1|,32261278|gb|AAP74178.1|,31980444|dbj |B AC77763.11,31980414|dbj |B AC77736.11,315 59678 |dbj |B AC77501.11,31559650|dbj |BAC77476.1 j,31559622|dbj |B AC77451.1 j,52000760|sp|Q9QPN3|NEF_HVlLA,128022|sp|P03407|NEF_HVlA2,548343 |sp|P35959|NEF_HVlY2,128018|sp|P04324|NEF_HV112,128027|sp|P19546|NEF_HVlSl,52001461|sp|P05857|NEF_HVlSC,128041 |sp|P04602|NEF_HVlZ6,128036|sp|P05858|NEF_HVlRH,128034|sp|P20886|NEF_HV10Y,12803 l|sp|Pl 8801 |NEF_HV1ND,128028|sp|P05859|NEF_HVlZH,128024|sp|P20867|NEF_HVlJR,

|46486652|gb|AAS98757.1|,|46254446|gb|AAS86196.1|,|38679165|gb|AAR26417.1|,119072112|dbj |B AB85759.11,|32261267|gb|AAP74168.1|,|31980434|dbj|B AC77754.11,|31559698 |dbj |B AC77519.1 j,|31559670|dbj |B AC77494.11,|31559640|dbj |B AC77467.11,

|56608856|gb|AAW03059.11|56608850|gb|AAW03056.1||56608844|gb|AAW03053.1||56608838|gb|AAW03050.1||56608832|gb|AAW03047.1||56608826|gb|AAW03044.1||56608820|gb|AAW03041.1||56608814|gb|AAW03038.1||56608808|gb|AAW03035.11|55925127|gb|AAV67933.1||51572120|gb|AAU06768.1||47060062|gb|AAT09648.1||49472939|gb|AAT66283.11|37682597|gb|AAQ98278.11|37682568|gb|AAQ98252.1||37682538|gb|AAQ98225.1||37682508|gb|AAQ98198.1 j|37682479|gb|AAQ98172.1 j

l57«1/l<OUUlAAr>OBK/l 1l

|t WUÍ.-TJ/ j^Lsj.1 W X -y-τ. X I

128017|sp|P03404|NEF_HVlBl,10436129|gb|AAG16809.1|, |10436110|gb|AAG16792.1|,1688156|gb|AAB36917.1|, |1688154|gb|AAB36916.1|,1688150|gb|AAB36914.1|, |1688148|gb|AAB36913.1|,

|37682439|gb|AAQ98136.1||46486670|gb|AAS98773.11|46486644|gb|AAS98750.1 j|46254422|gb|AAS86180.1||38679155|gb|AAR26408.1||32261289|gb|AAP74188.1||323 51110|gb|AAP76518. lj|31980424|dbj|BAC77745.1 j|31559688|dbj|BAC77510.1||31559660[dbj |B AC77485.11|31559630|dbj|BAC77458.1||4539079|emb|CAB39754.1||128023|sp|P03406|NEF_HVlBR|6093480|sp|P04601 |NEF_HV1H213024191 |sp IQ70627|NEF_HV 1LW|52001459|sp|P05854|NEF_HVlH3|128026|sp|P19545|NEF_HVlS3|52001460|sp|P05856|NEF_HVlMN|128038|sp|P24741|NEF_HVlU41128035|sp|P03405|NEF_HVlPV|128033|sp|P04603|NEF_HVlMA|128029|sp|P12479|NEF_HVlBN|128025|sp|P04604|NEF_HVlEL|128021|sp|P05855|NEF_HVlB8|18766391|gb|AAL78997.1|AF465242_9|1688158|gb|AAB36918.1|1688152|gb|AAB36915.1||1688146|gb|AAB36912.1]

1688144|gb|AAB36911.1|, |1688142|gb|AAB36910.1|, |1688140|gb|AAB36909.1|consenso, 118699252|gb|AAL78493.1 | AF414006_5,

1732483 |gb|AAB3 8831.11, |33358354|gb|AAQ16648.1|,33358350|gb|AAQ16646.1|,33358344|gb|AAQ16643.1|,

|1688136|gb|AAB36907.1|, |1688134|gb|AAB36906.1|,ll688130lgblAAB36904.ll, ll688128jgblAAB36903.il,|1688124|gb|AAB36901.11, |1688122|gb|AAB36900.1 j,|1688118|gb|AAB36898.1|, |221482|dbj|BAA00999.1|,|82278513|sp|011408|011408_9PLVG, |77272|pir||S03245,

1688138|gb|AAB36908.1|,1688132|gb|AAB36905.1|,1688126|gb|AAB36902.11,1688120|gb|AAB36899.11,1899130|gb|AAC57010.1|,77270|pir||S03246,18426920|gb|AAL69558.1|,82298824|sp|Q8QDN3|Q8QDN3_9PLVG,2895574|gb|AAD12143.1|,18699188|gb|AAL78448.1 |AF413987_3,58700473 |gb|AAW80948.1|, |58700471|gb|AAW80947.1|, |58700469jgbjAAW80946.1|,58700467|gb|AAW80945.1|, |58700465|gb|AAW80944.1|, |58700463|gb|AAW80943.1|,5 8700461 |gb|AAW80942.11, |328639|gb|AAA45064.11, |328424|gb|AAA44993.11,392792|gb|AAA03700.11 HIV-I consenso, |82294586|sp|Q85737|Q85737_9HIVl HIV-I

|77269|pir||S03247,|328560|gb|AAB59874.1|,

|326684|gb|AAA44330.11,|4262345|gb|AAD 145 81.1 j,|9629924|refl]S!P_046131.1|,|2828046|gb|AAB99967.11,|58700475|gb|AAW80949.11,

4ΑΚ</ΙΛ 11

w·'·' υ jx u IV^ χ υυτν. χ

|3335833 l|gb|AAQ16637.1|,|37725235|gb|AAR02299.1|,37725205|gb|AAR02272.1j,27227849|dbj|BAC45023.1|,23954624|gb|AAN40103.11 trancada

|33358348|gb|AAQ16645.1|,|33358342|gb|AAQl 6642.1|,

|1732492|gb|AAB38839.1|,|33358352|gb|AAQl 6647.1|,l33358346lgblAAQ16644.ll,|33358340|gb|AAQ16641.1|,

A AmmQ 11

I^ ---Tj^W I^-U ILV,/ X \J\J~t W. í j,

|37725255|gb|AAR02317.1|,|37725215 |gb|AAR02281.1 j,l27227859ldbjlBAC45032.ll,

|23954644|gb|AAN40113.11 tnmcada,

|1794250|gb|AAC56429.1|, |1794248|gb|AAC56428.1|,

h-JQCOQO^UUlA AAK^O 1l

|33358329|gb|AAQ16636.1|,|37725225|gb|AAR02290.1|,|37725193|gb|AAR02261.1|,

1794246|gb|AAC56427.111794240|gb|AAC56424.1|,1794234|gb|AAC56421.1|,1794228|gb|AAC56418.1 j,328038|gb|AAA44858.1|,82295433|sp|Q8AC97|Q8AC97_9HTVl,82287838|sp|Q6WWX7|Q6WWX7_9HIVl,82287836|sp|Q6WWX5|Q6WWX5_9HIVl,82287834|sp|Q6WWX3|Q6WWX3_9HIVl,82287832|sp|Q6WWXl |Q6WWX1_9HIV1,

[1794244|gb|AAC56426.1|, |1794242|gb|AAC56425.1|,11794238|gb|AAC56423.11, |1794236|gb|AAC56422.11,11794232|gb| AAC56420.11, 11794230|gb|AAC56419.11,|1794225|gb|AAC56417.1|, |328448|gb|AAA83398.1|,|82304199|sp|Q9E526|Q9E526_9ffiVl,|82295432|sp|Q8AC89|Q8AC89_9HTVl,|82287837|sp|Q6WWX6|Q6WWX6_9HIVl,|82287835|sp|Q6WWX4|Q6WWX4_9HIVl,|82287833 |sp|Q6WWX2|Q6WWX2_9HIVl,182287831 |sp|Q6WWX0|Q6WWX0_9HIVl,

82287830|sp|Q6WWW9|Q6WWW9_9HIVl, |82287829|sp|Q6WWW8|Q6WWW8_9HIVl,82287828|sp|Q6WWW7|Q6WWW7_9HIVl, |82287827|sp|Q6WWW6|Q6WWW6_9fflVl,

82287826|sp|Q6WWW5|Q6WWW5_9HIVl,82281644|sp]P90278|P90278_9HIVl,82281642|sp|P90276|P90276_9HIVl,82281640|sp|P90274|P90274_9HIVl,82281637|sp|P90272|P90272_9HIVl,82281635|sp|P90270|P90270_9HIVl,82281633 |sp|P90268|P90268_9HIVl,82281631 jsp |P90266|P90266_9HIV 1,82281284|sp|P88526|P88526_9HIVl,82281268|sp|P88425|P88425_9HIVl,82281266|sp|P88423 |P88423_9HIV1,82281264|sp|P88421|P88421_9fflVl,

|8228165 l|sp|P90287fP90287_9HIVl,|82281643 |sp |P90277|P90277_9HIV 1,|82281641 |sp|P90275|P90275_9HIVl,|82281638jsp |P90273|P90273_9HIV 1,|82281636ÍspjP9027ljP90271_9HIVl,|82281634|sp|P90269|P90269_9HIVl,|82281632|sp|P90267|P90267_9fflVl,|82281285|sp|P88528|P88528_9HIVl,|82281283]sp|P88524|P88524_9HIVl,|82281267|sp|P88424|P88424_9HIVl,|82281265|sp|P88422|P88422_9HTVl,|82281263|sp|P88420|P88420_9HIVl,|4205068|gb|AAD10940.1||4205041|gb|AAD10916.1|,l4205014lgblAAD10892.ll,|328667[gb|AAB59883.1|,|329404|gb|AAA45381.11,|328414|gb|AAA44984.1|,

|82281261|sp|P88418|P88418_9HIVl|82281259|sp|P88416|P88416_9HIVl|82281257|sp|P88414|P88414_9HIVl|82281255|sp|P88412|P88412_9HIVl|82281253|sp|P88410|P88410_9HIVl|8228125 l|sp|P88408(P88408_9HrVl|82281249|sp|P88406|P88406_9HIVl|82281247|sp|P88204|P88204_9HIVl|82278599|sp|011910|011910_9HTVl|82278597|sp|011908|011908_9HIVl|82278595|sp|011906|011906_9HIV1|4205059|gb|AAD10932.1||4205032|gb|AAD 10908.1 j|4205005|gb|AAD10884.1||326425|gb|AAB59752.1||328574|gb|AAA45058.1||328163|gb|AAA44874.1||82320738|sp|Q52S68|Q52S68_9HIVl|82320731 |sp|Q52S48|Q52S48_9HIVl

!Λ^ΛΛΑπη r i__IAfOCOTlACOCO'? O HJTAT-I

|82308242|sp|Q9YP51 |Q9YP51_9HIV1|82308240|sp|Q9YP45|Q9YP45_9fflVl|82308238|sp|Q9YP30|Q9YP30_9HIVl|82308047|sp|Q9YJ66|Q9YJ66_9HIVl|82307552|sp|Q9WJU3|Q9WJU3_9HTVl|82299117|sp|Q8USH4|Q8USH4_9HIVl

|82291331 |sp|Q79789|Q79789_9HIVl|82287922|sp|Q6XDS8|Q6XDS8_9HTVl|82282601 |sp|Q5EFT8|Q5EFT8_9HIVl|82282599|sp|Q5EFT6|Q5EFT6_9HTVl|82282597|sp|Q5EFT4|Q5EFT4_9HTVl|82282595|sp|Q5EFT2|Q5EFT2_9HTVl]62548206|gb|AAX86757.1|62548186|gb|AAX86739.11, |62548176|gb|AAX86730.1|8920160|emb|CAB96346.1|, |34330007|gb|AA065893.1

82281262|sp|P88419|P88419_9HTVl,82281260|sp|P88417|P88417_9HIVls82281258|5ρ|Ρ88415|Ρ88415_9ΗΤνΐ,82281256|sp|P88413|P88413_9HIVl382281254|sp|P88411 (P88411_9HIV1,82281252|5ρ|Ρ88409|Ρ88409_9Ηΐνΐ,82281250|sp|P88407|P88407_9HIVl,82281248|sp|P88405|P88405_9HIVl,82281243|sp|P88156|P88156_9HIVl,82278598|sp|011909|011909_9HIVl,82278596|sp|011907|011907_9KQYl,4205077|gb|AAD10948.1|,4205050lgbjAAD10924.il,4205023|gb|AAD10900.1|,4204996|gb|AAD10876.1|,329397|gb|AAB53951.1|,328458|gb|AAA45001.1|,326431 jgbj AAA44222.1 j,82320734jsp|Q52S57jQ52S57_9HIVl,82320728jspjQ52S38jQ52S38_9Hrv 1,82308345|sp|Q9YTC4]Q9YTC4_9HIVl,82308241 |sp|Q9YP47|Q9YP47_9HIVl,82308239|sp|Q9YP38|Q9YP38_9HIVl,82308236|sp|Q9YP24|Q9YP24_9HIVl,82307554|sp|Q9WJU7|Q9WJU7_9HrVl,82304713 |sp |Q9ID V1 |Q9IDV 1_9HIV 1,82296624|sp|Q8AQP7|Q8AQP7_9HIVl tnmcada,

82296614|sp|Q8AQN7|Q8AQN7_9HIVltniiicada,82290362|sp|Q77695|Q77695_9HIVl,82287920|sp|Q6XDS4|Q6XDS4_9HIVl,82282600|sp|Q5EFT7|Q5EFT7_9HIVl,82282598|sp|Q5EFT5|Q5EFT5_9HIVl,82282596|sp|Q5EFT3|Q5EFT3_9HrVl,82282594|sp|Q5EFTl|Q5EFTl_9HIVl,62548196|gb|AAX86748.11,62548166|gb|AAX86721.1 \,34330001 ]gb|AA065888.1|, |82291091|sp|Q79149|Q79149_9HIVl

As cepas do HIV preferidas aludidas na presente invenção, porexemplo contra as quais os presentes polipeptídeos devem ser imunogênicos,são aquelas contendo estas proteínas específicas. Os números de acesso acimaespecificam explicitamente a identidade da cepa além da seqüência deproteína específica.

A homologia percentual de uma primeira seqüência depolipeptídeo a uma segunda seqüência de polipeptídeo, como aludido nocontexto da presente invenção, é definida como o número de resíduos deaminoácido na segunda seqüência que se iguala tanto em posição (absoluta ourelativa) quanto em identidade com aquele na primeira seqüência, divididopelo número total de resíduos de aminoácido no segundo polipeptídeo (tanto oprimeiro quanto o segundo polipeptídeos deve ter o mesmo número deresíduos de aminoácido) e multiplicado por 100. Embora não uma ocorrênciacomum, nem todas as seqüências de proteína do HTV são idênticas nocomprimento para todas as cepas conhecidas. Existem casos de proteínas quesão um ou dois aminoácidos mais longos ou mais curtos do que oagrupamento geral. A pessoa habilitada pode facilmente identificar estasproteínas. Por esta razão, a definição acima estende-se à posição absoluta paraas proteínas do mesmo comprimento e posição relativa para proteínas decomprimentos diferentes.. Isto, entretanto, não afeta a definição da posiçãoreativa como definido com respeito à localização (por exemplo, doaminoácido 7 ao 37) dada acima. Na presente invenção, é preferido que ahomologia de polipeptídeo para as seqüências definidas seja 75 % ou mais, 85% ou mais, 95 % ou mais ou 100 % (ou substancialmente 100 %).

Os epítopos dentro das seqüências definidas acima não sãoespecialmente limitadas, contanto que contenham 7 resíduos de aminoácidoou mais. Preferivelmente os epítopos são de um comprimento que seja éapropriado para os epítopos CTL em uma espécie de vertebrado particular, talcomo em um ser humano, tendo um MHC específico. Tipicamente osepítopos contêm 8, 9, 10 ou 11 resíduos de aminoácido, mas podem contermais se desejado. No geral um epítopo apropriado é um que é um epítopo deCTL em um vertebrado tal como um ser humano.

Tipicamente, o polipeptídeo compreende entre 7 e 100aminoácidos, e preferivelmente de 8 a 50 aminoácidos. O tamanho não deveser tão grande que epítopos úteis sofram de competição com epítopos nãoprotetores no sistema imune (por esta razão proteínas completas não sãoincluídas), nem deve o tamanho ser tão pequeno que apenas uma faixa muitoestreita de proteção seja oferecida. As faixas mais preferidas são de 8 a 45aminoácidos, 15 a 45 aminoácidos e 20 a 45 aminoácidos e 15 a 35aminoácidos. O comprimento mais preferido é de 25 a 45 resíduos deaminoácido. É particularmente preferido que o polipeptídeo consistasubstancialmente de uma seqüência selecionada das seqüências nas posiçõesdefinidas acima na lista específica de proteínas apresentadas acima.

Além dos polipeptídeos descritos acima, que não devem sermaiores do que 100 resíduos de aminoácido no comprimento, a invençãotambém fornece polipeptídeos imunogênicos de epítopo múltiplo quecompreendem dois ou mais polipeptídeos da presente invenção. Estespolipeptídeos de epítopo múltiplo não são limitados no tamanho. Assim, elesse estendem não apenas aos polipeptídeos tendo de 7 a 100 resíduos deaminoácido como esboçado acima, mas também aos polipeptídeos maiores,contanto que estes polipeptídeos maiores compreendam duas ou maisunidades, cada unidade consistindo de um polipeptídeo da invenção. Assim,um polipeptídeo tendo 100 unidades de repetição de um 7-mer de acordo coma presente invenção é abrangido pela presente invenção, como é umpolipeptídeo tendo, digamos 52 unidades de um epítopo de 8-mer, e 23unidades de um segundo epítopo de 10-mer. Os polipeptídeos deste tipo nãosofrerão dos problemas de competição associados com polipeptídeos decomprimento similar que compreendem apenas um ou dois epítopos. Para seevitar dúvidas, o polipeptídeo de epítopo múltiplo pode compreender cópiasmúltiplas do mesmo epítopo ou cópias únicas de uma pluralidade de epítoposdiferentes ou cópias múltiplas de 2 ou mais epítopos.

Também é fornecido pela invenção uma composição depolipeptídeo que compreende dois ou mais polipeptídeos diferentes comodefinido acima. Assim, a composição de polipeptídeo pode compreenderqualquer número de polipeptídeos da presente invenção juntos na mesmamistura ou formulação. A presença de uma pluralidade de polipeptídeosjuntos é útil visto que cada um pode evocar a sua própria resposta imune,ampliando o efeito protetor da composição. É particularmente preferido que acomposição contenha todas as seqüências das SEQ ID 1 a 4 cada uma em umpeptídeo separado ou diversas em um número menor de peptídeos (porexemplo, 3 combinadas em um peptídeo maior e as outras três 3 em um outropeptídeo maior, etc.).

A invenção também fornece uma construção de polipeptídeo,construção esta que compreende um polipeptídeo como definido acima e umcarreador. A construção pode ser formada combinando-se dois ou maisepítopos e/ou um polipeptídeo como definido acima com o carreador. Ocarreador pode ser uma molécula, tal como um adjuvante e/ou um excipiente.A combinação neste contexto significa misturar junto ou ligar junto (porexemplo, por intermédio de uma ligação covalente).

A presente invenção fornece ainda um polipeptídeo comodefinido acima para o uso na medicina. Também é fornecido ummedicamento ou composição de vacina contra um vírus da imunodeficiência,tal como o HIV, que compreenda um polipeptídeo como definido acima, e umou mais excipientes e/ou adjuvantes apropriados (se a parte carreadora daconstrução é por si só um excipiente ou adjuvante, então um outro excipienteou adjuvante pode não ser necessário). O excipiente ou adjuvante não éespecialmente limitado, e quaisquer excipientes ou adjuvantes habitualmenteusados em medicamentos e vacinas podem ser utilizados. A composição devacina ou medicamento podem ser produzidos de acordo com qualquermétodo conhecido apropriadamente adaptado para a presente invenção, talcomo misturando-se um polipeptídeo da invenção com um excipiente ouadjuvante apropriados.

Um método para produzir um polipeptídeo como definidoacima também é fornecido pela invenção. O método não é especialmentelimitado, e tipicamente compreende unir dois ou mais epítopos para formar opolipeptídeo. O polipeptídeo, entretanto, pode ser sintetizado pela síntesedireta química (por exemplo, incorporando um aminoácido em um tempo atéque o polipeptídeo completo seja formado) ou pelos métodos recombinantes.Tais métodos gerais são bem conhecidos para a pessoa habilitada e podem seradaptados para a presente invenção como desejado. Em alguns casos, opolipeptídeo da presente invenção pode compreender seqüências deaminoácido adicionais em um ou ambos os terminais para ajudar na síntese dopolipeptídeo. Estas seqüências adicionais são preferivelmente de 1 a 5aminoácidos no comprimento. Tipicamente 3 aminoácidos são envolvidos.Por exemplo, um pode incluir uma cisteína (C) ou uma cadeia Gly-Cys (G-C)no terminal N ou C de modo a permitir a ligação química a outroscomponentes de proteína.

A invenção fornece ainda o uso de um polipeptídeo oucomposição como definidos acima, na fabricação de um medicamento ouvacina, eficaz no tratamento ou prevenção de um vírus da imunodeficiência,tal como o HIV. Também é fornecido um método para tratar ou prevenir umvírus da imunodeficiência tal como o HIV, método este que compreendeadministrar um polipeptídeo, uma composição, um medicamento ou umavacina como definidos acima a um vertebrado. O método de administraçãonão é especialmente limitado, e pode compreender a administraçãosubcutânea, intramuscular, intravenosa, intradérmica, transdérmica ouintranasal ou pode ser administrado oralmente (por exemplo, na forma de umapílula ou uma preparação líquida) ou pode estar na forma de um supositório,se desejado. A forma de tais preparações de administração não éespecialmente limitada, e formas conhecidas podem ser utilizadas commodificações apropriadas que estarão evidentes para a pessoa habilitada. Adosagem não é especialmente limitada e pode variar de 1 ng a 100 g dopolipeptídeo por indivíduo, dependendo do tamanho, peso e espécie doindivíduo envolvido.

A invenção pode ser aplicada a qualquer vertebrado, visto queos sistemas imunes de vertebrados operam em uma maneira relacionada.Tipicamente, o vertebrado aludido no presente contexto é um mamífero. Éespecialmente preferido que o vertebrado seja um ser humano.

Os exemplos de MHCs humanos (HLAs) que podem serutilizados com a presente invenção incluem os seguintes:

HLA-A

À*010101, A*010102, A*010103, A*0102, A*0103, A*0104N, À*0106, A*0107, A*010S,A*0109, AseOUOs A*Q2010101? A*02010102L, A*020102, A*020103, A*020104,A*020105, A*020106, A*020107, A*020108, A*020109, A*020110, A*020111, A*0202,A*020301, A*020302, A*0204, A*0205, A*020601, A*020602, A*020603, A*0207,A*0208, A*0209, A*0210, A*021l, A*0212, A*0213, A*0214, A*0215N, A*0216,A*021701, A*021702, A*0218, A*0219, A*02200I, A*022002, A*0221, A*0222, A*0224,A*0225, A*0226, A*0227, A*0228, A*0229, A*0230, A*0231, A*0232N, A*0233,A*0234, A*023501, A*023502, A*0236, A*0237, AisOlSSj A*0239, A*0240, A*0241,A*0242, A*0243N, A*0244, A*0245, A*0246, A*0247, A*0248, A*0249, A=tlOlSO,A*0251, A*0252, A*0253NS A*0254, A*0255, A*0256, A*0257, A*0258, A*0259,A*0260, A*0261, A*0262, A*0263, A*0264, A*0265, A*0266, A*0267, A*0268, A*0269,A*0270, A*0271, A*0272, A*0273, A*03010101, A*03010102N, A*03010103, A*030102,Αφ030103, A*0302, A*0303N, A*0304, A*0305, A*0306, A*0307, A*0308, A*0309,A*0310, Α*Ό311Ν, A*0312, A*0313, A*0314, A^l 10101, A*110102, A* 1102, AlfcIl03,A* 1104, A* 1105, A*Í106, A*1107, ΑΉ108, A*U09, A*H10, A*llll, A*1112, A*IX13,A*3114, A*1115, A*1116, AifeIll?, A*1118, A*U19, A*2301, A*2302, A*2303, A*2304,A*2305, A*2306, A*2307N, A*2308N, A*2309, A*2310, A*2311N, A*2312, A*24020101,A*24020102L, A*240202, A*240203, A*240204, A*240205, A*240206, A*240301,A*240302s A*2404, A*2405, A*2406, A*2407, A*2408, A*2409N, A*2410, A*2411N,A*2413, A*2414, A*2415, A*2417, A*2418, A*2419, A*2420, A*2421, A*2422, A*2423,Α*2424, A*2425, A*2426, A*2427, A*2428, A*2429, A*2430, Α*2431, A*2432, A*2433,A*2434, A*2435, A*2436N, A*2437, A*2438, A*2439, A*2440N, A*2441, A*2442,A*2443, A*2444, A*2445N, A*2446, A*250101, A*250102, A*2502, A*2503, A*2504,A*2601, A*2602, A*2603, A*2604, A*2605, A*2606, A*260701, A*260702, A*2608,Α*2609, Α*2610, Α*2611Ν, Α*2612, Α*2613, Α*2614, Α*2615, Α*2616, Α*2617,Α*2618, Α*2619, Α*2620, Α*2621, Α*2622, Α*2623, Α*29010101, Α*29010102Ν,Α*290201, Α*290202, Α*290203, Α*2903, Α*2904, Α*2905, Α*2906, Α*2907, Α*2908Ν,Α*2909, Α*2910, Α*2911, Α*300101, Α*300102, Α*300201, Α*300202, Α*3003, Α*3004,Α*3006, Α*3007, Α*3008, Α*3009, Α*3010, AiiSOll, Α*3012, Α*310102, AlilS 102,Α*3103, Α*3104, Α*3105, Α*3106, AniOTi Α*3108, Α*3109, Α*3110, Α*3201, Α*3202,Α*3203, Α*3204, Α*3205, Α*3206, Α*3207, Α*3208, Α*3301, Α*330301, Α*330302,Α*3304, Α*3305, Α*3306, Α*3307, Α*3401, Α*3402, Α*3403, Α*3404, Α*3405, Α*3406,Α*3601, Α*3602, Α*3603, Α*3604, Α*4301, Α*6601, Α*6602, Α*6603, Α*6604,Α*680101, Α*680102, Α*680103> Α*6802, Α*680301, Α*680302, Α*6804, Α*6805,Α*6806, Α*6807> Α*6808, Α*6809, Α*6810} Α*6811Ν, Α*6812, Α*6813, Α*6814,Α*6815, A*ó8ló, Α*6817, A*681SN, A*6819s A*Ó820: Α*6821, Α*6822, Α*6823,Α*6824, Α*6825, Α*6826, Α*6827; Α*6901, Α*7401, Α*7402, Α*7403, Α*7404, Α*7405,Α*7406, Α*7407, Α*7408, Α*7409, Α*7410, Α*8001.

HLA-B

6*070201, Β*070202, Β*070203, Β*070204, Β*0703, Β*0704, Β*0705, Β*0706, Β*0707,Β*0708, Β*0709, Β*0710, Β*0711, Β*0712, Β*0713, 6*0714, 6*0715, 6*0716, Β*0717,Β*0718, 6*0719, 6*0720, 6*0721, Β*0722, Β*0723, Β*0724, Β*0725, Β*0726, Β*0727,Β*0728, 6*0729, 6*0730, 6*0731, 6*0732, 6*0733, 6*0734, 6*0735, 6*0736, Β*0737,6*0738, B4=OSOl, 6*0802, 6*0803, 6*0804, 6*0805, Β*0806, 6*0807, Β*0808Ν, Β*0809,6*0810, 6*0811, 6*0812, 6*0813, Β*0814, BssOSlSs Β*0816, Β*0817, Β^ΟδΙδ, Β*0819Ν,6*0820, Β*082Ii Β*0822, 6*1301, 6*1302, Β*1303, Β* 1304, Β*1306, Β*1307Ν, 6*1308,Β*1309, Β*1310, 6*1311, Β*1312, 6*1313, 6*1401, 6*1402, 6Π403, Β*1404, Β*1405,Β*140601, Β*140602, Β*1501010Ι, 8*15010102Ν, Β*150102, 6*150103, Β* 150104,6*150105, Β*1502, 6*1503, Β* 1504, Β*1505, Β*1506, 6*1507, 6*1508, 6*1509, Β*1510,Β*15Ι101, Β*151102, Β*1512, Β*1513, Β*1514, Β*1515, Β*1516, Β*15170101,Β*15170102, BnSIS, Β*1519, Β+1520, Β*1521, Β*1523, Β*1524, Β*1525, Β*1526Ν,Β* 1527, Β* 1528, Β*1529, Β*1530, Β*1531, B*1532, Βη$33, Β*1534, Β*1535, Β+1536,Β* 1537, Β*1538, Βη53% 6*1540, Β*1542, 6*1543, Β*1544, Β*1545, Β*1546, Β*1547,Β*1548, Β*1549, Β*1550, 6*1551, 6*1552, 6*1553, Β*1554, Β«1555, Β*1556, Β*1557,Β*1558, Β*1560, Β*156Ι, Β*1562, 6*1563, 6*1564, 6*1565, Β*1566, Β*1567, Β*1568,Β* 1569, Β* 1570, BiiISTl, Β*1572, Β*1573, Β*1574, Β*1575, 8*1576, 8*1577, 8*1578,6*1579Ν„ Β* 1580, 6*1581, 6*1582, 8*1583, 8*1584, 8*1585, Β*1586, 8*1587, Β*Ϊ588,Β* 1589, Β*1590, Β*1591, Β*1592, Β*1593, Β*1594Ν, 6*180101, 8*180102, 8*1802,Β* 1803, Β*1804, Β*1805, 6*1806, 8*1807, 6*1808, 6*1809, 8*1810, B=fcISll, 8*1812,8*1813, Β* 1814, Β*1815, Β*1817Ν, Β*1818, 6*1819, 6*1820, 8*2701, 8*2702, 6*2703,8*2704, Β*270502, Β*270503, 8*270504, Β*270505, Β*270506, Β*270507, Β*2706,8*2707, Β*2708, 8*2709, 6*2710, Β*2711, 8*2712, 6*2713, 8*2714, Β*2715, Β*2716,6*2717, Β*2718, 6*2719, Β*2720, 8*2721,6*2723, 8*2724, 8*2725, Β*2726, 6*350101,8*350102, Β*3502, Β*3503, 6*3504, Β*3505, Β*3506, Β*3507, 8*3508, 8*350901,6*350902, 6*3510, 6*3511, B*35t2, Β*3513, Β*351401, Β*351402, Β*3515, 8*3516,Β*3517, 6*3518, Β*3519, 8*3520, 8*3521, 8*3522, Β*3523, Β*3524, 8*3525, 8*3526,8*3527, 6*3528, Β*3529, Β*3530, Β*3531, Β*3532, 6*3533, 6*3534, 6*3535, 6*3536,8*3537, 6*3538, 6*3539, Β*3540Ν, 6*3541, Β*3542, 8*3543, 8*3544,8*3545, 8*3546,6*3547, Β*3548, Β*3549, Β*3550, Β*3551, Β*3552, 6*3553Ν, 8*3701, Β*3702,8*3703Ν, 8*3704, Β*3705, 8*3706, Β*3707, Β*3801, 8*380201, 6*380202, 6*3803,6*3804, 8*3805, Β*3806, Β*3807, Β*3808, Β*3809, Β*3810, Β*390101, 6*390103,8*390104, 8*390201, 8*390202, 8*3903, Β*3904, 8*3905, 8*390601, Β*390602,8*3907, Β*3908, Β*3909, Β*3910, Β*3911, 6*3912, 8*3913, 8*3914, Β*39Ι5, 8*3916,8*3917,8*3918, 8*3919, 6*3920, 8*3922, 8*3923, Β*3924, Β*3925Ν, 8*3926, 8*3927,6*3928, 6*3929, 6*3930, 6*3931, 6*3932, 6*400101, 6*400102, B*400103, Β*400104,Β*400105, 6*400201, 6*400202, 6*4003, 8*4004, 6*4005, 8*40060101, 6*40060102,6*4007, 6*4008, 8*4009, 6*4010, 6*4011, 6*4012, 8*4013, 8*401401, Β*401402,Β*401403, Β*4015, Β*4016, 8*4018, Β*4019, Β*4020, 8*4021, Β*4022Ν, Β*4023,8*4024, Β*4025, Β*4026, Β*4027, Β*4028, Β*4029, 6*4030, Β*4031, Β*4032, 8*4033,6*4034, Β*4035, Β*4036, 8*4037, 8*4038, Β*4039, Β*4040, 6*4042, 6*4043, 8*4044,8*4045, 8*4046, 8*4047, 8*4048, 8*4049, 8*4050, Β*4051, Β*4052, 8*4053, 8*4054,8*4055, Β*4056, 8*4057, Β*4101, 6*4102, Β*4103, Β*4104, Β*4105, Β*4106, Β*4201,8*4202, Β*4204, Β*420501, Β*420502, Β*4206, 8*44020101, B*44020102S, Β*440202,Β*440203» Β*440301, 8*440302, 8*4404, Β*4405, Β*4406, 8*4407, 8*4408, Β*4409,8*4410, Β*4411, Β*4412, Β*4413, Β*4414, Β*4415, Β*4416, 8*4417, Β*4418, Β*4419Ν,6*4420, 8*4421, 8*4422, 8*4423Ν, Β*4424, Β*4425, 8*4426, 6*4427, Β*4428, Β*4429,Β*4430, Β*4431, Β*4432, Β*4433, Β*4434, 8*4435, 6*4436, 6*4437, 8*4438, 8*4439,Β*4440, Β*4501, Β*4502, Β*4503, Β*4504, Β*4505, Β*4506, Β*4507, Β*4601, 6*4602,8*4603, Β*4604, ΒΜ7010101, Β*47010102, Β*4702, Β*4703, Β*4704, Β*4705, Β*4801,Β*4802, Β*4803, Β*4804, Β*4805, Β*4806, Β*4807, B*480S; 6*4809, 8*4810, Β*4901,ΒΉ902, 8*4903, Β*5001, 6*5002, Β*5004, Bi=SlOlOl, Β*510102, Β*510103, Β*510104,Β*510105, Β*510201, Β*510202, 8*5103, Β*5104, Bs=SlOS, Β*5106, Β*5107, Β*5108,Β*5109, BssSllO, Β*5111Ν, Β*5112, 8*511301, Β*511302, Β*5114, 6*5115, Β*5116,Β*5117, 8*5118, Β*5119, Β*5120, Β*5121, Β*5122, 8*5123, 8*5124, Β*5126, Β*5127Ν,Β*5128, Β*5129, Β*5130, Β*5131, Β*5132, Β*5133, Β*5134, 3*5135, Β*5136, Β*520101,6*520102, Β*520103, 6*520104, 8*5202, Β*5203, 6*5204, Β*5205, Β*5206, Β*530101,8*530102, Β*5302, Β*5303, 8*5304, Β*5305,6*5306, Β*5307, Β*5308, Β*5309, Β*5401,Β*5402, 6*5501, 6*5502, 6*5503, 6*5504, 6*5505, Β*5507, 6*5508, 6*5509, 6*5510,B=3iSSlli Β*5512, Β*5513: Β*5514; Β*5515, Β*5516, 6*5601, 6*5602, 6*5603, 6*5604,Β*560501, Β*560502, Β*5606, Β*5607, Β*5608, 8*5609, 6*5610, Β*5611, Β*5612,Β*5613, 6*5614, 6*570101, 6*570102, Β*5702, 6*570301, Β*570302, Β*5704, Β*5705,6*5706, 6*5707, Β*5708, Β*5709, Β*5801, Β*5802, 6*5804, 6*5805, Β*5806, Β*5807,Β*5808, 8*5809, Β*5810Ν, 6*5901, 8*670101, 8*670102, Β*6702, Β*7301, Β*7801,8*780201, Β*780202, 6*7803, Β*7804, Β*7805, Β*8101, Β*8102, Β*8201, Β*8202,Β*8301.

HLA-C

Cw*010201, Cw*010202, 0*0103, Cw*0104, Cw*0105, 0*0106, 0*0107, Cw*0108,0*0109, Cw*0110, 0*020201, 0*020202, Cw*020203, Cw*020204, 0*020205,Cw*0203, Cw*0204, Cw*0205, Cw*0206, Cw*02Q7, Cw*0208, Cw*0209, Cw*030201,Cw*030202, Cw*030301, 0*030302, Cw*030303, 0*030304, Cw*030401, 0*030402,Cw*030403, Cw*0305, Cw*0306, 0*0307, Cw*0308, 0*0309, 0*0310, 0*0311,0*0312, 0*0313, 0*0314, Cw*03i5, 0*0316, Cw*0317, Cw*0318, 0*04010101,Cw*04010102, Cw*040102, Cw*0403, Cw*040401, 0*040402, 0*0405, 0*0406,0*0407, Cw*0408, Cw*0409N, Cw*0410, Cw*0411, Cw*0412, Cw*0413, 0*0414,Cw*04l5, Cw*050101, Cw*050102, Cw*0502, 0*0503, 0*0504, 0*0505, 0*0506,0*0507N, 0*0508, Cw*0509, 0*0510, 0*0602, 0*0603, Cw*0604, 0*0605,Cw*0606, 0*0607, 0*0608, 0*0609, Cw*0610, 0*0611, 0*070101, Cw*070l02,Cw*070l03, 0*07020101, 0*07020102, 0*07020103, Cw*0703? 0*070401,Cw*070402, Cw*0705, Cw*0706, Cw*0707, Cw*0708, Cw*0709, 0*0710, Cw*0711,Cw*0712, Cw*0713, W0714, Cw*0715, Cw*0716, Cw*0717, Cw*0718, Cw550719,Cw*0720, Cw*0721, Cw*0722, Cw*0723, Cw*0724, Cw*0725, Cw*0726, Cw*0727,Cw*0728, Cw*0729, Cw*080101? Cw*080102, Cw*0802, Cw*0803, Cw*0804, Cw*0805,Cw*0806, Cw*0807, Cw*0808, Cw*0809, Cw*0810, Cw*0811, Cw*0812, Cw* 120201,Cw*120202, Cw* 120203, Cw* 120301, Cw*120302, Cw* 120303, Cw=5120401, Cw*120402,Cw* 1205, Cw* 1206, Cw* 1207, Cw*1208, Cw*1209, Cw* 1210, Cw*12ll, Cw* 1212,Cw*1213, Cw* 1214, Cw*1215, Cwii=140201, Cw4tI40202, Cw* 140203, Cw*1403,Cw* 1404, Cw*1405, Cw* 150201, CwH50202, Cw* 1503, Cw* 1504, Cw* 150501,Cw* 150502, Cw* 150503, CVH50504, Cw*1506, 0*1507, Cw*1508, Cw*1509,Cw* 1510, Cw*1511, Cw*1512, Cw* 1601, Cw* 1602, Cw* 160401, Cw* 1606, Cw* 1701,Cw*1702, Cw* 1703, Cw* 1801, Cw* 1802.

HLA-E

EjftOlOls E*010301,1*010302, E*010303, B*0104.HLA-F

F*010l01»F*010mHLA-G

G*010101, G*010102, G*010103, G*010104, G*010105, G*010106, G*010107, G*0I0108,G*0102,0*0103, G*010401, G*010402, G*010403, G*0105N, G*0106.

HLA-DRBl

DRB 1*010101, DRB1*010102, DRB1*010103, DRB1*010201, DRB1*010202,DRB1*010203, DRB1*010204, DRB1*0103, DRB1*0104, DRB1*0105, DRB1*0106,DRB 1*0107, DRBP0108, DRB1*0109, DRB1*0110, DRB1*0111, DRB1*030101,DRB1*030102, DRB1*030201, DRB1*030202, DRB1*0303, DRB1*0304, DRB1*030501,DRB1*030502, DRB1*0306, DRB 1*0307, DRB1*0308, DRB1*0309, DRB 1*0310,DRB1*0311, DRB 1*0312, DRBl=itOSlSj DRB1*0314, DRB1*0315, DRB1*0316,DRB 1*0317, DRB1*0318, DRB 1*0319, DRB 1*0320, DRB 1*03213 DRB1*0322,DRB 1*0323, DRB1*0324, DRB1*0325, DRB1*0326, DRB1*0327, DRB 1*0328,DRB1*040101, DRB 1*040102, DRB1*0402, DRBl «040301, DRB 1*040302, DRB 1*0404,DRB1*040501, DRB 1*040502, DRB1*040503, DRBP040504, DRB 1*0406,DRB 1*040701, DRB1*040702, DRB 1*040703, DRB1*0408, DRB 1*0409, DRB 1*0410,DRB 1*0411, DRB 1*0412, DRB1*0413, DRB1*0414, DKB1*0415, DRB1*0416,DRB 1*0417, DRB 1*0418, DRB 1*0419, DRB 1*0420, DRB 1*0421, DRB1*0422,DRB1*0423, DRB1*0424, DRB 1*0425, DRB 1*0426, DRB 1*0427, DRB1*0428,DRB1*0429, DRB1*0430, DRB1*0431, DRB1*0432, DRB1*0433, DRB 1*0434,DRB1*0435, DRB1*0436, DRB1*0437, DRB 1*0438, DRB1*0439, DRB 1*0440,DRB1*0441, DRB1*0442, DRB 1*0443, DRB1*0444, DRB1*0445, DRB1*0446,DRB1*0447, DRB1*0448, DRB 1*0449, DRB 1*0450, DRB1*070101, DRB1*070102,DRB1*0703, DRB1*0704, DRB 1*0705, DRB 1*0706, DRB1*0707, DRB1*0708,DRB 1*080101, DRB1*080102, DRB1*080201, DRB 1*080202, DRB1*080203,DRB 1*080302, DRB 1*080401, DRB1*080402, DRB1*080403, DRB 1*080404,DRB1*0805, DRB1*0806, DRB1*0807, DRB1*0808, DRB1*0809, DRBP0810,DRB 1*0811, DRB1*0812, DRB1*0813, DRB1*0814, DRB1*0815, DRB1*0816,DRB 1*0817, DRB 1*0818, DRB 1*0819, DRB1*0820, DRB 1*0821, DRB1*0822,DRBP0823, DRB1*0824, DKB 1*0825, DRB 1*0826, DRB 1*0827, DRB1*0828,DRBP0829, DRB1*090102, DRB1*090103, DRB1*0902, DRB1*0903, DRB1*100101,DRBl* 100102, DRB1*110101, DRB1*110102, DRB1*110103, DRB1*110104,DRB1*11010S, DRB1*1102, DRB1*1103, DRB1*110401, DRB1*110402, DRB1*1105,DRB1*110601, DRBP110602, DRB1*1107, DRB1*110801, DRB1*110802> DRB1*1109,DRB1*1110, DRB1*1111, DRB1*111201, DRB1*111202, DRB1*1113, DRB1*1114,DRBl *1115, DRB1*1116, DRB1*1117, DRB1*1118, DRB1*1119, DRB1*1120,DRB1*1121, DRBl *1122, DRBIH123, DRB1*1124, DRB1*1125, DRB1*1126,DRB1* 112701, DRB1*112702, DRB1*1128, DRB1*1129, DRBl*li30, DRB1*1131,DRBI*1132, DRB1*1133, DRBl*1134, DRB1*1135, DRB1*1136, DRB1*1137,DRB1*1138, DRB1*1139, DRBl*1140, DRB1*1141, DRB1*1142, DRB1*1143,DRB1*1144, DRBl *l 145, DRB1*1146, DRB1*U47, DRB 1*1148, DRB 1*1149,DRB1*1150, DRB1*1151, DRB1*1152, DRB1*1153, DRB1*1154, DRB1*120101,DRBl*120102, DRB1*120201, DRB 1*120202, DRB1*120302, DRB1*1204, DRBl* 1205,DRBl* 1206, DRB1*1207, DRB1*1208, DRB1*1209, DRB1*1210, DRB1*130101,DRB1*130102, DRB1* 130103, DRB1*130201, DRBl * 130202, DRBlsfiDOSOl,DRB1*130302, DRB1H304, DRBl--BOS, DRB1*1306, DRB1*130701, DRB1*130702,DRBl *1308, DRB1*1309, DRBlsi=BlO5 DRB1*1311, DRB1*1312, DRB1*1313,DRB1*131401, DRBP131402, DRB1*1315, DRB1*1316, DRB1*1317, DRB1*1318,DRB1*1319, DRB1*1320, DRB1*1321} DRB1*1322, DRB1*1323, DRB1*1324,DRB1*B25, DRB 1*1326, DRB1*1327, DRB1*1328, DRBl *1329, DRB1*1330,DRBl*1331, DRBl * 1332, DRB1*1333, DRBl*! 334, DRB1*1335, DRB1*1336,DRBl * 1337, DRB1*1338, DRB1*1339, DRBP1340, DRB1*1341, DRB1*1342,DRB1*1343, DRB1*1344, DRBl sltI 345, DRB1*1346, DRB1*1347, DRB1*1348,DRBl *B49. DRBl * 1350, DRBl*1351, DRB1*1352, DRB1*1353, DRB1*1354,DRB1*1355, DRB1*1356, DRB1*1357, DRB1*1358, DRB1*1359, DRB1*1360,DRB1*1361, DRB1*1362, DRB1*1363, DRB1*1364, DRB1*1365, DRB1*140101,DRB1*140102, DRB 1*1402, DRB1*140301, DRBl* 140302, DRBl* 1404, DRBIssHOSOI,DRB1*140502, DRB P1406, DRB1*14O701, DRB1*140702, DRB1*1408, DRBP1409,DRB1*1410, DRB1*1411, DRB1*1412, DRB1*1413, DRBl*1414, DRB1*1415,DRB1*1416, DRB1*14Í7, DRB1*1418, DRB1*1419, DRB1*1420, DRB1*1421,DRB1*1422, DRB 1*1423, DRB1*1424, DRB1*Í425, DRB 1*1426, DRBl * 1427,DRB1*1428, DRB1*1429, DRB1*1430, DRBlsltHSl, DRB1*1432, DRB1*1433,DRB1*1434, DRB1*Í435, DRBP1436, DRB1H437, DRB1*1438, DRB P1439,DRBl *1440, DRBl * 1441, DRB 1*1442, DRB 1*1443, DRB 1*1444, DRB1*1445,DRB1*1446, DRB1*1447, DRB1*1448, DRB1*150101, DRB1*150102, DRBlsiiISOlOS,DRBl * 150104, DRB1*150105, DRB 1*150201, DRB 1*150202, DRB F150203,DRBl * 1503, DRB1*1504, DRB1*1505, DRB1*1506} DRB1*1507, DRB1*1508,DRBl * 1509, DRBl * 1510, DRB1*1511, DRB1*1512, DRBinSB, DRBP1514,DRB1*1515, DRB1*1516, DRB1*160101, DRB 1*160102, DRB1*160201, DRBF160202,DRBl^l 603, DRB1*1.604, DRB1*I60501, DRB1*160502, DRBP1607, DRB1*1608.

HLA-DRB2-9

DRB2*0101, DRB3*010101, DRB3*01010201, DRB3*01010202, DRB3*010103,DRB3*010104, DRB3*0102, DRB3*0103, DRB3*0104, DRBSsfsOlOS, DRB3*0106,DRB3*0107, DRBS=feOlOSj DRB3*0109, DRB3*0110, DRB3*0111, DRB3*0201,DRB3*020201, DRB3*020202, DRB3*020203, DRB3*020204, DRB3*0203, DRB3*0204,DRB3*020S, DRB3*0206, DRB3*0207, DRB3*0208, DRB3*0209, DRB3*0210,DRB3*0211, DRB3*0212, DRB3*0213, DRB3*0214, DRB3*0215, DRB3*0216,DRB3*0217, DRB3*0218, DRB3*0219, DRB3*030101, DRB3*030102, DRB3*0302,DRB3*0303, DRB4*01010101, DRB4*0102, DRB4*01030101, DRB4*01030102N,DRB4*010302, DRB4*010303, DRB4sS010304, DRB4*0104, DRB4*0105, DRB4*0106,DRB4*0107, DRB4*0201N, DRB4*0301N, DRB5*010101, DRB5*010102, DRBS*0102,DRB5*0103, DRB5*0104, DRB5*0105, DRB5*0106, DRBS=iiOlO?, DRB5*0108N,DRB5*0109, DRBS4iOllON, DRB5*0111, DRB5*0112, DRBS*0113, DRB5*0202,DRB5*0203, DRB5*0204, DRB5*0205, DRB6*0101, DRB6*0201, DRB6*0202,DRB7*0!0101, DKB7*Q10102, DRB8*0101?DRB9*0101.

HLA-DQAl

DQAl+OlOlOli DQAl *010102, DQA1*010201, DQAlsf=Ol 0202, DQA1*0103}DQA1*010401, DQAl *010402, DQA1*0105, DQA1*0106, DQAl=liOlO?, DQA1*0201,DQAl *03 ΟΙΟΙ, DQAl*0302, DQA1*0303, DQAliWOlOl, DQA1*040102, DQA1*0402,DQA1*0403N, DQA1*0404, DQAlisOSOlOi, DQA!*050102, DQA1*0502, DQAP0503,DQAI*0504, DQA1*0505, DQA1*060101JDQA1*060102,DQA1*0602.

HLA-DQBl

DQBl*02010i, DQB1*020102, DQB1*0202, DQB1*0203, DQBliiOSOiOl, DQB1*030102,DQB1*030201, DQB P030202, DQB1*030302, DQB 1*030303, DQB 1*0304,DQB1*030501, DQB1*030S02, DQBlsfcOSOSOS, DQB1*0306, DQB 1*0307, DQB 1*0308,DQB1*0309, DQB 1*0310, DQB1*0311, DQB 1*0312, DQB1*0313, DQB1*0401,DQB1*0402, DQBPOSOIOI, DQB1*050102, DQB1*050201, DQB1*050202,DQBi*0S0301, DQB1*050302, DQB 1*0504, DQB1*060101, DQB 1*060102,DQBl *060103, DQB1*0602, DQB1*0603, DQB 1*060401, DQB1*060402, DQB 1*060501,DQB 1*060502, DQB1*0606, DQBlft0607, DQB1*0608, DQB 1*0609, DQB1*0610,DQB1*061101, DQB1*061102, DQB1*0612, DQB1*0613, DQBI*0614, DQB1*0615,DQB 1*0616, DQB1*0617, DQB1*0618, DQBP 0619, DQB 1*0620, DQB1*0621,DQB 1*0622, DQB 1*0623.HLA-DPAl

DPAl *010301, DPAl *010302, DPAl *010303, DPA1*0104, DPA1*0105, DPAFO106,DPAls5Ol07, DPAliiiOlOS, DPA1*020101, DPA1*020102, DPA1*020103, DPA1*020104,DPAl *020105, DPA1*020106, DPA1*020201, DPA1*020202, DPA1*020203,DPA1*0203, DPAl*0301, DPA1*0302, DPA1*0303, DPA1*0401.

HLA-DPBl

DPB1*010101, DPB1*010102, DPBP010103, DPB1*0102, DPB1*020102, DPB 1*020103,DPB1*020104, DPB 1*020105, DPB1*020106, DPB1*0202, DPB1*0203, DPB1*030101,DPB 1*030102, DPB1*0302, DPBl-040101, DPB 1*040102, DPB 1*0402, DPB 1*0501,DPB1*0601, DPB1*0801, DPB1*0901, DPB1*1001, DPB1*110101, DPB1*110102,

TYimi ΦΙ ΊΜ 4. # * 4. V A j DPBI*14Q1, DPB1*1501. DPB1*1601, DPB1*1701, DPB1*1801,DPB 1*1901, DPB1*200101, DPBl *200102, DPB1*2101, DPB1*2201, DPB1*2301,DPB 1*2401, DPB 1*2501, DPB1*260101, DPB1*260102, DPB1*2701, DPB 1*2801,DPB1*2901, DPB1*3001, DPB1*3101, DPB1*3201, DPB1*3301, DPB 1*3401,DPB 1*3501, DPBP3601, DPB1*3701, DPB1*3801, DPB 1*3901, DPB1*4001,DPB 1*4101, DPBP4401, DPB1*4501, DPB 1*4601, DPB1*4701, DPB1*4801,DPB1*4901, DPB1*500Í, DPB1*5101, DPB1*5201, DPB 1*5301, DPBP5401,DPB 1*5501, DPB1*5601, DPB 1*5701, DPB1*5801, DPB 1*5901, DPB1*6001,DPB1*6101N, DPBF6201, DPB 1*6301, DPB1*6401N, DPB1*6501, DPB1*6601,DPB1*6701, DPB1*6801, DPB1*6901, DPB 1*7001, DPB 1*7101, DPB 1*7201,DPB 1*7301 j DPB1*7401, DPB1*7501, DPB1*7601, DPB 1*7701, DPB1*7801,DPB 1*7901, DPB 1*8001, DPB1*8101, DPB 1*8201, DPB 1*8301, DPB1*8401,DPB 1*8501, DPB 1*8601, DPB1*S701, DPB 1*8801, DPB 1*8901, DPB1*9001,DPB 1*9101, DPB1*9201, DPB1*9301, DPB1*9401, DPB 1*9501, DPB1*9601,

DPB1*9701, DPB1 *9S0l, DPB1*9901.HLA-DMA

DMA*0101, DMA*0102, DMA=i5OlOS5 DMA*0104.HLA-DMB

DMB*0101, DMB*0102, DMB*0103, DMB*0104, DMB*01G5, DMB*0106.

HLA-DOA

DOÀ*01010I, DOA*()l 010201, DOA*01010202, DOA*01010203, DOAiiiOlOlOS,

DOA*01010401, DOA*01010402, DOA*010105.

HLA-DOB

DOB*01010101, DOB*01010102, DOB*010102, DOB*010201,006*010202, DOB*0103,

POB*01040101, DOB^O1040102.

A invenção não é limitada a tais moléculas de HLA, e pode seradaptada a tais moléculas recém descobertas, se desejado, simplesmenteestabelecendo-se a reatividade de substâncias tais como peptídeos com asmoléculas. Isto pode ser facilmente obtido usando-se técnicas conhecidas quesão padrão no campo. Os alelos HLA particularmente preferidos para o usocom a presente invenção incluem os seguintes:HLA Classe I

HlA Á HLAB HLACwA*6802 B*5801 Cw*1701A*6801 B*5701 Cw* 1601A*6601 B*5501 Cw* 1502A*3303 B*5201 Cw* 1402A*3301 B*5101 Cw* 1203A*3201 B*5001 Cw*0802A*310102 B*4901 Cw*0801A*3002 B*4501 Cw*0704A*3001 B*4403 0*0703A*2902 B*4402 Cw*0702A*2608 B*4101 Cw*0701A*2601 B*4002 Gw*0602A*250l B*4001 Cw*0501A*2402 B*3901 Cw*0401A*2301 B*3801 Cw*0304A* HOl B*370Í Cw*0303A*0302 B*3503 Cw*0202A*0301 B*3501 Cw*0102A*0205 B*2705 A*0201 B^1801 AskOlOl B*1501 B*1402 B*1401 B*1302 B*0801 B*0705 B*0702HLA Classe II

HLAPPB HLADOA HLA DOB HLADKB

DPB 1*1701 DQA1*0505 DQB1*0604 DRB1*1601DPBinSOl DQA1*0501 DQB 1*0603 DRB1*1501DPB1*1001 DQAl*0401 DQB1*0602 DRBl«1401DPB 1*0601 DQAl *0303 DQB 1*0503 DRB 1*1302DPB 1*0501 DQAl=5iOSOa DQB1*0502 DRB1*1301DPB 1*0402 DQA1*0301 DQB1*0501 DRB1*1201DPB 1*0401 DQA1*0201 DQB1*0402 DRB1*1104DPB1*0301 DQAl *0104 DQB1*0303 DRB1*1101DPB 1*0201 DQA1*0103 DQB1*0302 DRB1*0801DPB 1*0101 DQAl *0102 DQB1*0301 DRB1*0701DQA1*0101 DQB1*0202 DRB1*0404DQB1*0201 DRB1*0401DRB1*0301DRB 1*0103DBB1*0102DRB1*0101

Os alelos mais preferidos de acordo com a invenção são os

seguintes:

HLA-A*0201, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*2402, HLA-A*34G1,HLA-B*0702, HLA-B*0801, HLA-B*1301, HLA-B*27, HLA-B*4002, HLA-B*5101,HLÁ-Cw*03s HLA-cW*07

HLA-DRB 1*0301, HLA-DRB1*0401, HLA-DRBÍ*0701, HLA-DRB1*1501, HLA-DRB1*1104, HLA-DRB 1*1101, HLA-DRB4*0101

HLA-DQAlsliOl, HLA-DQA1*02, HLA-DQAl *05

HLA-DQB1*03, HLA-DQB 1*04, HLA-DQB 1*05, HLA-DQB 1*06

HLA-DPA1*01, HLA-DPAl *02

HLA-DPB1*02, HLA-DPB 1*04

A invenção será agora descrita por via de exemplo apenas,com referência às seguintes formas de realização específicas.EXEMPLOS

EXPERIMENTO 1 - Reatividade contra antígenos do HIV

O propósito do estudo é avaliar a reatividade dos polipeptídeosde HIV descritos acima e a sua capacidade para induzir uma resposta decitocina tipo Thl específica contra proteínas do HTV naturalmenteprocessadas e apresentadas no contexto de HLA humana (HLA A*0201).

Como fundo para os experimentos, é útil entender que asrespostas Thl e Th2 são definidas pelo padrão de citocinas produzidas pelascélulas auxiliares T envolvidas nelas. Isto, entretanto, não significa que oslinfócitos remanescentes (células TeB) envolvidos nestas respostasespecíficas também não produzam citocinas que ajudam a direcionar o padrãocaracterístico de resposta em que elas estão envolvidas. Deste modo, umaresposta equivalente a Thl é caracterizada pela produção de IFN-γ e IL-2,levando à estimulação de uma resposta CTL CD8+ e uma resposta deanticorpo IgG2a associada (em camundongos). A resposta IFNI pode serproduzida tanto pelas células auxiliares 1 T CD4+ assim como pelas células TCD8+ que também formam parte desta. Neste caso o componente de IFN-γ daresposta produzida pelas células T CD8+ foi investigado. Isto foi porque oexperimento primariamente investigou epítopos de célula T CD8+ e foidesejável provar que a resposta observada foi causada por aquelas células.Visto que as células T CD8+ reagem com epítopos apenas nas moléculasMHC de classe I, as células humanas que compartilham com o camundongotransgênico apenas uma molécula MHC de classe I (isto é, HLA-A*0201)foram usados. Uma resposta equivalente a Th2 é caracterizada pela produçãode IL-4 e IL-10, levando à estimulação de uma resposta de anticorpo IgGE,IgGl e (em camundongos) IgG2b. Ambas as respostas são antagonísticas comIFN-γ e IL-IO infra-regulando a produção um do outro.

Todos os experimentos descritos abaixo foram realizados emduplicata.

Materiais e métodos

Peptídeos e proteínas recombinantes

Todos os polipeptídeos usados neste estudo (isto é, PI: VPR aa51 a 80 (SEQ ID 1); P2: VIF: aa 142 a 181 (SEQ ID 2); P3: REV aa 69 a 95(SEQ ID 3); P4: NEF: aa 81 a 123 (SEQ ID 4); e NRP: um polipeptídeo nãorelevante de controle foram sintetizados pela química de Fmoc e recolocadosem suspensão em DMSO a 10 % em PBS.

As proteínas recombinantes YIF do HTV-I (ref: EVA659),REV (fusão de rótulo His; ref: ARP663.2) e NEF (ref: EVA650) foramobtidas do Repository of HTV reagents (NIBSC, UK). As preparações deproteína foram misturadas em quantidades equimolares em PBS a 1 mg/ml earmazenadas a -80° C até o uso.

Linhagens de Célula

As linhagens de célula T Tl e JURKA são linhagens delinfoblastóides humanos derivados de indivíduos que carregam e que nãocarregam HLA-A*0201 respectivamente. A Tl foi mantida em meio IMDM(Invitrogen) enquanto a JURKAT foi mantida em meio RPMI-1640 (Sigma)contendo 10 mM de HEPES e 1 mM de piruvato de sódio. Ambos os meios15 foram suplementados com 50 RJ/50 mg/ml de penicilina/estreptomicina(Sigma) e, como meio completo, 10 % de FCS. As culturas celulares forammantidas a 37° C em uma atmosfera umidificada de 5 % de CO2.

Os esplenócitos primários foram mantidos em meio IMDM(Invitrogen) suplementado com 0,02 mM de β-mercaptoetanol (Sigma), 50IU/50 mg/ml de penicilina/estreptomicina (Sigma) e 10 % de FCS (Sigma) a37° C em uma atmosfera umidificada de 5 % de CO2.Preparação de células alvo para a análise de citocina

As culturas de célula na fase exponencial foram colhidas pelacentrifugação (250 g, 5 min) e recolocadas em suspensão a uma densidade de106 células/ml em meio isento de soro. As alíquotas das suspensões de célulaforam transfectadas com uma faixa de antígenos de polipeptídeo a umaconcentração de 5 μg por IO6 células usando Lipofectina (Invitrogen) deacordo com as instruções do fabricante e incubadas em meio completo por 8 ahoras antes do tratamento com Mitomicina C (MMC).Para o tratamento com MMC5 as células foram colhidas pelacentrifugação (250 g, 5 min) e recolocadas em suspensão em meio IMDMisento de soro contendo 50 μg/ml de Mitomicina C (Sigma). Depois de 45min de incubação a 37° C, as suspensões de célula foram lavadas quatro vezesem meio de IMDM isento de soro (250 g, 5 min) e finalmente recolocadas emsuspensão em meio IMDM completo.

Imunizações

Camundongos C57BL/6-Tg(HLA-A2.1)lEnge/J de sete a dezsemanas de idade (transgênicos em HLA-A*0201 em um fundo C57/BL6,Jackson Labs) foram imunizados intradermicamente com uma dose de 100 μΐ(liberada em 5 locais a 20 μΐ/local) por camundongo da preparação deantígeno. No grupo de teste, cada dose da preparação de antígeno conteve 40nmoles de uma mistura equimolar de todos os quatro peptídeos (HIV-v) (10nmoles de cada) e 0,5 nmoles de Subunidade B da Toxina da Cólera (>99 %pura, BioMol) e foi preparada em Lipofectina (Invitrogen) de acordo com asinstruções do fabricante. No grupo de controle, cada dose da preparação deantígeno conteve 40 nmoles do polipeptídeo não relevante e 0,5 nmol daSubunidade B da Toxina da Cólera (>99 % pura, BioMol) e foi preparada emLipofectina (Invitrogen) de acordo com as instruções do fabricante.

No dia 14 após a imunização, todos os animais receberam umaimunização de reforço usando as mesmas doses e via de liberação comousadas originalmente. Finalmente, nos dias 21 ou 22, todos os animais foramescolhidos e seus baços coletados.

O protocolo de imunização pode ser representadoesquematicamente como segue:

Esquema 1 - inoculação<figure>figure see original document page 170</figure>

ELISA de Citocina

Os baços de camundongo que pertencem ao mesmo grupoexperimental foram reunidos, suavemente prensados através de peneiras decélula e as células sangüíneas vermelhas removidas pelo tratamento comtampão de Iise de célula vermelha (nove partes de NH4Cloreto 0,16 M e umaparte de Tris 0,17 M, pH 7,2). As suspensões de esplenócito de cada grupoexperimental foram plaqueadas em placas de 24 reservatórios a umadensidade de 4 χ IO6 células/reservatório contendo uma faixa de antígenos depolipeptídeo (5 μg/ml) ou, alternativamente, linhagens de célula tratadas comMMC (a razão de esplenócito para célula (S:C) de 10:1) transfectada comantígenos de polipeptídeo como descrito acima.

Depois de 4 dias de incubação a 37° C, o sobrenadante foicoletado e analisado quanto a IFN-γ e IL-4 por um ELISA de citocinaintercalado de acordo com o protocolo do fabricante (Pharmingen). Os limitesde detecção inferiores para o ensaio foram 9,77 pg/ml para IL-4 e 39,06 pg/mlpara IFN-γ.

Depois de 4 dias de incubação a 37° C, o sobrenadante foicoletado e analisado quanto IFN-γ e IL-4 por um ELISA de citocinaintercalado de acordo com o protocolo do fabricante (Pharmingen). Os limitesde detecção inferiores para o ensaio foram 9,77 pg/ml para IL-4 e 39,06 pg/mlpara IFN-γ.

Resultados

Reatividade do peptídeo 1

Cada um dos polipeptídeos descritos neste pedido de patente(incluindo PI, P2, P3 e P4 testados neste Exemplo) contém diversos epítoposde célula T CD8+ dos quais diversos são específicos para HLA-A*0201. Noprocessamento interno do polipeptídeo pelas células que apresentam antígeno(APCs) de um receptor que carrega HLA-A*0201, estes epítopos específicosde célula T CD8+ são apresentados na superfície da APC de onde eles seoriginam para ativar as células T CD8+ ingênuas e induzem uma respostaimune equivalente a Thl específica para o peptídeo que é testado, neste casoP1,P2, P3 e P4.

Para confirmar isto, as linhagens de célula humanas quecarregam (Tl) e que não carregam (JURKAT) HLA-A*0201 foramintracelularmente carregadas com Pl por meio de um veículo delipídeo (Lipofectina, INVITROGEN). Os esplenócitos de animaisimunizados com a preparação de polipeptídeo do HIV (HIV-v)foram descobertos produzir níveis aumentados de IFN-γ comparadoscom esplenócitos de animais imunizados com NRP quando co-cultivadascom células humanas que carregam HLA-A*0201 (Tl) tratadas comMMC transfectadas com PI, mas não quando co-cultivadas com célulashumanas que não carregam HLA-A*0201 (JURKAT) tratadas do mesmomodo (ver a Figura 1, os dados para os quais são apresentados na Tabela 1abaixo).Tabela 1

<table>table see original document page 172</column></row><table>

Nota:

"Lys" significa o fundo do controle negativo no qual todos osvalores são calculados. "Sol" significa peptídeo solúvel apresentado àpopulação de esplenócito primária. "Pro" significa que o peptídeo está sendoapresentado complexado com as moléculas de células HLA a seguir deprocessamento interno e carregamento dos epítopos resultantes nas moléculasde MHC. Os valores representam a média ± erro padrão da Δ IFN-γ para Lys(pg/ml).

O experimento pode ser representado esquematicamente comosegue:

Esquema 2 -teste de controle para Tle JURKAT

Tl trasfectada com Pl (ou P2 etc.)ou

rantígeno de camundongo que apresenta células deixada apresentar Plnaturalmente pela adição de Pl (ou P2 etc.) aos esplenócitos

APC(HLA)-Pl+ -► Nenhuma reação (nenhuma IFNI-γ)

células T reativas ao APC(HLA)-NRP

A inoculação de control foi com NRP

JURKAT trasfectadas com Pl (ou P2 etc.)ou

células que apresentam antígeno de camundongo deixadas apresentarPl naturalmente pela adição de Pl (ou P2 etc.) aos esplenócitos

APC (não HLA)-P1 + -► Nenhuma reação (nenhum IFN-γ)

células T reativas ao APC(HLA)-NRP

A inoculação de control foi com NRPEsquema 3 - resultados de teste do HTV-v para Tle JURKAT

Tl trasfectada com Pl (ou P2 etc.)ou

células que apresentam antígeno de camundongo deixadas apresentarPl naturalmente pela adição de Pl (ou P2 etc.) ao esplenócitos

AP C(HLA)-P 1 + HLA

células T reativas ao APC(HLA)-Pl -►

(ou P2 etc)

A inoculação foi com HIV-v

JURKAT trasfectada com Pl (ou P2 etc.)ou

células que apresentam antígeno de camundongo deixadas apresentar Plnaturalmente pela adição de Pl (ou P2 etc.) aos esplenócitos

APC (não HLA)-P 1 +

células T reativas ao APC(HLA)-Pl -Nenhuma reação (nenhum IFNI)

(ou P2 etc.)

4

N— A inoculação foi com HIV-v

Visto que os camundongos transgênicos usados nestesexperimentos não carregam nenhuma outra HLA humana e a capacidadedestas células T CD8+ para reconhecer especificamente epítopos derivados dePl no contexto de outras HLAs humanas que elas nunca encontraram é baixo,estes resultados claramente mostram que a resposta de IFN-γ observada éespecificamente causadas pelas células T CD8+ para reconhecer epítoposderivados de Pl em associação com moléculas HLA-A* 0201.

Também é importante mencionar que nenhuma resposta de IL-4 pôde ser detectada contra as células transfectadas com Pl em animaisimunizados com HIV-v ou NRP (dados não mostrados). Visto que a produçãode IL-4 é antagonística em relação ás respostas de Thl e por este motivo paraa criação de respostas de célula T CD8+ específicas de antígeno, a falta daprodução de IL-4 em cada grupo claramente mostra que a imunização comHTV-v induz uma resposta equivalente a Thl específica para o componentePl da preparação.

De maneira interessante, nenhum diferencial na produção deIFN-γ pôde ser observado no HTV-v comparado com os grupos imunizadoscom NRP quando Pl é simplesmente adicionado à cultura (na ausência decélulas Tl ou JURKAT). Esta situação, entretanto, pode ser explicada combase em que Pl contém primariamente epítopos que são reativos no contextode HLAs humanas e não de camundongo. Os camundongos transgênicosusados nestes experimentos contêm um complemento completo de moléculasde MHC de camundongo além das moléculas HLA-A*0201. Portanto, asculturas de esplenócito primárias aqui consideradas contêm diferentespopulações de célula T (CD8+ e CD4+) capazes de responder ao antígenoapresentado no contexto das moléculas de MHC tanto humanas quanto decamundongo presentes na população de APC de camundongo tambémencontrados nestas culturas. Apenas uma pequena fração do antígeno Plcapturado e processado por estes APCs seriam esperados estar disponíveispara os linfócitos T CD8+ específicos de Pl no contexto de HLA-A*0201requerido. Visto que o nível de uma resposta imune in vitro é primariamentedeterminada pela disponibilidade de antígeno, os linfócitos T CD8+específicos de Pl detectados quando células humanas foram usadas comoestimuladores simplesmente seriam incapazes de responder devido à falta deantígeno suficiente apresentado a elas no contexto de HLA-A*0201apropriado.

Reatividade de peptídeo 2

Os esplenócitos de animais imunizados com a preparação depolipeptídeo do HIV (HIV-v) foram descobertos produzir níveis aumentadosde IFN-γ comparados com esplenócitos de animais imunizados com NRPquando co-cultivados com células humanas que carregam HLA-A*0201tratadas com MMC (Tl) transfectadas com P2, mas não quando co-cultivadascom células humanas que não carregam HLA-A* 0201 (JURKAT) tratadas domesmo modo (ver a Figura 2, os dados para os quais são apresentados naTabela 2 abaixo).

Tabela 2

<table>table see original document page 175</column></row><table>

Nota:

"Lys" significa o fundo do controle negativo no qual todos osvalores são calculados. "Sol" significa peptídeo solúvel apresentado àpopulação de esplenócito primária. "Pro" significa que o peptídeo está sendoapresentado complexado com as moléculas de células HLA a seguir deprocessamento interno e carregamento dos epítopos resultantes nas moléculasde MHC. Os valores representam a média ± erro padrão da Δ IFN-γ para Lys(pg/ml).

Como foi o caso para PI, estes resultados claramente mostramque a resposta IFN-γ observada é especificamente causada pelas células TCD8+ que reconhecem epítopos derivados de P2 em associação commoléculas HLA-A*0201.

Também é importante observar que nenhuma resposta IL-4pôde ser detectada contra as células transfectadas com P2 em animaisimunizados com HIV-v ou NRP (dados não mostrados). Visto que a produçãode IL-4 é antagonística em relação ás respostas Thl e por este motivo àcriação de respostas de célula T CD8+ específicas de antígeno, a falta deprodução de IL-4 em cada grupo claramente mostra que a imunização comHIV-v induz uma resposta equivalente a Thl específica ao componente P2 dapreparação.

Ao contrário de PI, a produção de IFN-γ aumentada pôde serobservada no HIV-v comparada com os grupos imunizados com NRP quandoΡ2 é simplesmente adicionado à cultura de esplenócito. Esta situaçãoclaramente mostra que P2 abriga não apenas epítopos de HLA-A*0201 fortesmas também epítopos (H2-D) de camundongo. É importante, entretanto,salientar que a resposta de lFN-γ medida neste caso pode não estarunicamente associada com as moléculas de MHC de Classe I. As célulasdendríticas mostraram (Peachman KK, Rao M, Alving CR, Palmer DR, SunW, Rothwell SW, "Human dendritic cells and macrophages exhibit differentintracellular processing pathways for soluble and liposome-encapsulatedantigens." Immunobiology. 2005; 210(5): 321-33) serem capazes de processarin vitro no antígeno solúvel do caminho de MHC Classe II capturado do meio.Como um resultado a resposta de IFN-γ aumentada observada neste caso podeser originada por cada uma ou ambas das células T CD8+ e CD4+ específicasde P2.

Reatividade de peptídeo 3

Similarmente ao P2, a produção de IFN-γ aumentada pôde serobservada nos grupos imunizados com HIV-v comparado com NRP quandoP3 é simplesmente adicionado à cultura de esplenócito. As causas para istoforam explicadas anteriormente e por este motivo não devem ser mais aquidesenvolvidas.

Com respeito ao componente específico de HLA-A* 0201 daresposta, mais uma vez como foi o caso para Ple P2, a produção aumentadade IFN-γ é observada em animais imunizados com HIV-v comparados comaqueles que recebem NRP, mas a um grau menor do que em Pl (ver a Figura3, os dados para os quais são apresentados na Tabela 3 abaixo). Estaobservação é explicada em termos similares àqueles fornecidos para Pl.

Tabela 3<table>table see original document page 176</column></row><table>Nota:

"Lys" significa o fundo do controle negativo no qual todos osvalores são calculados. "Sol" significa peptídeo solúvel apresentado àpopulação de esplenócito primária. "Pro" significa que o peptídeo está sendoapresentado complexado com as moléculas de células HLA a seguir deprocessamento interno e carregamento dos epítopos resultantes nas moléculasde MHC. Os valores representam a média ± erro padrão da Δ IFN-γ para Lys(pg/ml).

As culturas de esplenócito primárias dos animais transgênicosaqui usados contêm populações de célula T diferentes (CD8+ e CD4+)capazes de responder ao antígeno apresentado no contexto das moléculas deMHC tanto humanas quanto de camundongo presentes na população de APCde camundongo também encontrada nestas culturas. A seguir da vacinação, osepítopos derivados de P3 tanto da Classe I quanto da Classe II poderiam tersido apresentadas às células T CD8+ e CD4+. Visto que o número demoléculas HLA-A* 0201 nas APCs de camundongo apenas representam umapequena fração do número total de moléculas de MHC presentes (isto é, todasas moléculas H2-D mais as moléculas HLA-A* 0201), apenas uma fração doantígeno P3 total liberado estaria disponível às células T CD8+ com umaespecificidade para HLA-A*0201. Tanto in vivo como in vitro, a intensidadeda resposta de célula T é primariamente dependente da disponibilidade doantígeno. Portanto, em uma situação onde haveria competição intensa entre asmoléculas de MHC quanto aos epítopos P3, segue que estas moléculas querepresentam uma pequena fração da população seriam responsáveis apenaspor uma pequena fração da resposta IFN-γ total.

Reatividade do peptídeo 4

Similarmente à PI, a produção de IFN-γ aumentada pode serobservada na HIV-v comparada com os grupos imunizados com NRP quandoP4 é simplesmente adicionado à cultura de esplenócito assim como quando éapresentado por intermédio de linhagens de células humanas transfectadas(ver a Figura 4, os dados para a qual são apresentados na Tabela 4 abaixo).Visto que as causas para estas observações já foram explicadas para o caso dePl as mesmas não devem ser mais aqui desenvolvidas e deve-se referir a estaseção mais no início.

Tabela 4

<table>table see original document page 178</column></row><table>

Nota:

"Lys" significa o fundo do controle negativo no qual todos osvalores são calculados. "Sol" significa peptídeo solúvel apresentado àpopulação de esplenócito primária. "Pro" significa que o peptídeo está sendoapresentado complexado com as moléculas de células HLA a seguir deprocessamento interno e carregamento dos epítopos resultantes nas moléculasde MHC. Os valores representam a média ± erro padrão da Δ IFN-γ para Lys(pg/ml).

Reatividade para as proteínas recombinantes do HIV

Até agora os experimentos aqui descritos têm claramentemostrado que a imunização com HTV-v induz uma resposta de IFN-γespecífica de célula T CD8+ contra cada um de seus componentesconstituintes. Entretanto, é útil estabelecer se os camundongos vacinados comHIV-v são capazes de reconhecer, e conseqüentemente induzir uma respostaimune específica para, epítopos criados na captura e processamento dasproteínas do HTV completas das quais alguns deles são derivados. Devido aosconceitos de segurança de usar vírus HIV vivo em células humanas foidecidido estudar a resposta de IFN-γ em camundongos vacinados com HIV-ve NRP usando o mesmo método usado para PI, P2, P3 e P4, mas neste casousando como antígenos estimuladores uma mistura equimolar de VIF, REV eNEF.

Mais uma vez, a vacinação com HIV-v de animais deu origema um aumento específico na produção de IFN-γ comparada com a vacinaçãode NRP independentemente se a preparação de antígeno equimolar foisimplesmente adicionada à cultura ou apresentada às células T CD8+ ativadaspor intermédio de células humanas transfectadas (ver a Figura 5, os dadospara os quais são apresentados na Tabela 5 abaixo). De maneira interessante,a produção de fundo de IFN-γ em todos os casos foi maior do queanteriormente observado, provavelmente refletindo a capacidade dapreparação de proteína equimolar para induzir uma resposta IFN-γ nãoespecífica nas culturas de esplenócito primárias ou mudanças nas célulashumanas transfectadas que as tornam mais suscetíveis para induzir a produçãode IFN-γ não específica nos esplenócitos com os quais elas foram co-cultivadas. Esta observação, entretanto, não deprecia o fato evidente de que avacinação com HIV-v leva ao reconhecimento específico de epítopo HLA-A*0201 do HIV naturalmente processado e apresentado a partir de proteínasdo HIV completas.

Tabela 5

<table>table see original document page 179</column></row><table>

Nota:

"Lys" significa o fundo do controle negativo no qual todos osvalores são calculados. "Sol" significa peptídeo solúvel apresentado àpopulação de esplenócito primária. "Pro" significa que o peptídeo está sendoapresentado complexado com as moléculas de células HLA a seguir deprocessamento interno e carregamento dos epítopos resultantes nas moléculasde MHC. Os valores representam a média ± erro padrão da Δ IFN-γ para Lys(pg/ml).EXPERIMENTO 2 - A imunização pela HIV-v induz uma resposta específicade antígeno contra células humanas infectadas com isolados de campo doHIV

O propósito deste estudo é avaliar se a imunização com os5 polipeptídeos de epítopo de célula T conservados do HIV identificados (HIV-v) induz e resposta específica de antígeno contra células humanas infectadascom isolados de campo do HIV.Materiais e métodosPeptídeos, vírus e linhagem de célula

A vacina candidata (HIV-v) usada neste estudo é composta dediversos polipeptídeos (isto é, PI: VPR aa 51 a 80 (SEQ ID 1); P2: VIF: aa142 a 181 (SEQ ID 2); P3: REV aa 69 a 95 (SEQ ID 3); P4: NEF: aa 81 a 123(SEQ ID 4)) que foram todos sintetizados pela química de Fmoc e recolocadaem suspensão em DMSO em PBS (a concentração de DMSO na preparaçãofinal foi menor do que 10 %). A Lisozima (Sigma) desnaturada pela ebuliçãofoi usada como a preparação não relevante de controle (NRP-v).

As cepas HIV-I infecciosas foram originadas de NIBSC erepresentaram isolados Ugandenses de HTV-I Glado D (UG21-R5) e Glado A(UG-29-X4). CEM é uma linhagem de célula T linfoblastóide CD4+susceptível à infecção pelos isolados do HIV denominados acima. Estalinhagem de célula foi mantida em meio RPMI-1640 (Sigma) suplementadocom 50 IU/50 mg/ml de penicilina/estreptomicina (Sigma) e, como meiocompleto, 10 % de FCS. As culturas de célula foram mantidas a 37° C emuma atmosfera umidificada de 5 % de CO2.

Os esplenócitos primários foram mantidos em meio IMDM(Invitrogen) suplementado com 0,02 mM de β-mercaptoetanol (Sigma), 50IU/50 mg/ml de penicilina/estreptomicina (Sigma) e 10 % FCS (Sigma) a 37°C em uma atmosfera umidificada de 5 % de CO2.ImunizaçõesNo dia 1, camundongos C57BL/6-Tg(HLA-A2.1)lEnge/J desete a dez semanas de idade (transgênicos em HLA-A*0201 em um fundoC57/BL6, Jackson Labs) foram imunizados subcutaneamente na base dacauda com uma dose de 200 μΐ da preparação de antígeno emulsificada emIFA (Sigma). No grupo de teste (n = 4), cada dose da preparação de antígenoconteve 40 nmoles de uma mistura equimolar de todos os quatro peptídeos(10 nmoles cada) enquanto que no grupo de controle (n = 4), cada dose dapreparação de antígeno conteve 40 nmoles do polipeptídeo não relevante.

No dia 15 todos os animais receberam uma imunização dereforço usando as mesmas doses e vias de liberação como usadasoriginalmente.

No Dia 21 todos os animais foram escolhidos e seus baçoscolhidos.

Tingimento de citocina intracelular

Os baços de camundongo pertencente ao mesmo grupoexperimental foram reunidos, suavemente prensados através de peneiras decélula e as células sangüíneas vermelhas removidas pelo tratamento comtampão de Iise de célula vermelha (nove partes de NH4Cl 0,16 M e uma partede Tris 0,17 M, pH 7,2). As suspensões de esplenócito de cada grupoexperimental foram plaqueadas em placas de 96 reservatórios (falcon, BDdiscovery labware) a uma densidade de 2 χ 10^5 células/reservatório contendoIonomicina (0,78 μg/ml) e PMA (0,05 μg/ml), Concanavalina A a 5 μg/ml ou2 χ 10^4 células CEM irradiadas com UV infectadas e não infectadas com HIV(razão de esplenócito para célula (S:C) 10:1).

Depois de 3 horas de incubação a 37° C com 5 % de CO2,Brefeldin A foi adicionado a todos os reservatórios a 10 μ§/ηι1 deconcentração final. As placas foram depois incubadas por mais 3 horas placasa 37° C e depois as placas transferidas a um refrigerador a +4° C paraarmazenagem durante a noite. Depois da centrifugação (200 g, 5 min), osobrenadante foi removido dos reservatórios e as células contra tingidas comanticorpo anti-CD3-FITC por 15 a 20 minutos na temperatura ambiente noescuro. As células foram depois lavadas com PBS pela centrifugação (200 g,5 min), fixadas por 20 min na temperatura ambiente (reagente de fixação A,Caltag) e lavadas mais uma vez. Depois de permeabilizar as células por 20min (reagente de permeabilização B, Caltag) na temperatura ambiente, ascélulas foram lavadas e os anticorpos anti-IFNy-PE e anti-IL4-APCadicionados. Depois de 30 min de incubação, as células foram lavadas duasvezes e recolocadas em suspensão em 40 % (p/v) de formaldeído em PBSantes de ser analisado em um citômetro de fluxo.

Resultados

O propósito deste estudo foi avaliar a capacidade dapreparação de HIV-v para induzir a imunidade específica de antígeno emcamundongos transgênicos HLA*A-0201 contra células humanas infectadascom HIV compatíveis com HLA.

Como mostrado na Fig. 6, os esplenócitos de animaisimunizados com HIV-v produziram níveis mais altos de IFN-γ quando co-cultivados contra células humanas infectadas com isolados do vírus HIV-IGlado D (UG21-R5) ou Glado A (UG-29-X4) do que os esplenócitos deanimais imunizados com um polipeptídeo não relevante. Nenhuma respostade IL-4 contra as células alvo foi observada em nenhum dos gruposexperimentais (dados não mostrados).

Os resultados deste estudo indicam que a vacinação com apreparação de peptídeo HIV-v induz uma resposta de célula T tipo Thlespecífica de patógeno contra diferentes ciados de vírus HIV circulantes.

Claims (30)

1. Polipeptídeo tendo não mais do que 100 aminoácidos,caracterizado pelo fato de que compreende uma ou mais seqüências tendopelo menos 60 % de homologia com qualquer uma das SEQ ID 1 a 4 oucompreende dois ou mais epítopos tendo 7 aminoácidos ou mais, cada epítopotendo pelo menos 60 % de homologia com uma subseqüência de qualqueruma das SEQ ID 1 a 4 que tem o mesmo comprimento como o epítopo:SEQ ID 1 GDTWAGVEAIIRILQQLLFIHFRIGCQHSRSEQ ID 2 KVGSLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQ KTSEQ ID 3 EPVPLQLPPLERLTLDCSEDCGTSGTQSEQ ID 4 YKGALDLSHFLKEKGGLEGLIYSQKRQDILDL WVYHTQGYFPDem que, o polipeptídeo é imunogênico em um vertebrado queexpressa um alelo de complexo de histocompatibilidade maior (MHC), e emque o polipeptídeo não é uma proteína do vírus HIV completa.

2. Polipeptídeo tendo não mais do que 100 aminoácidos,caracterizado pelo fato de que compreende uma ou mais seqüências definidaspelos seguintes resíduos de aminoácido de uma proteína do vírus HIV oucompreende dois ou mais epítopos tendo 7 aminoácidos ou mais de umaseqüência definida pelos seguintes resíduos de aminoácido de uma proteínado vírus HIV:resíduos 51 a 80 de uma proteína VPRresíduos 142 a 181 de uma proteína VIFresíduos 69 a 95 de uma proteína REVresíduos 81 a 123 de uma proteína NEFem que, o polipeptídeo é imunogênico em um vertebrado queexpressa um alelo de complexo de histocompatibilidade maior (MHC), e emque o polipeptídeo não é uma proteína do vírus HIV completa.

3. Polipeptídeo de acordo com as reivindicações 1 ou 2,caracterizado pelo fato de que compreende um linfócito T citotóxico (CTL),epítopo de célula T CD8+ e/ou célula T CD4+.

4. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que compreende 2,3,4,-5 ou mais epítopos.

5. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que é imunogênico aum epítopo dentro de qualquer uma das seqüências das SEQ ID 1 a 4.

6. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que é imunogênico auma cepa do HIV.

7. Polipeptídeo de acordo com a reivindicação 6, caracterizadopelo fato de que é imunogênico a uma pluralidade de cepas do HIV.

8. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que compreende aindauma ou mais seqüências adicionais de uma proteína viral daimunodeficiência.

9. Polipeptídeo de acordo com a reivindicação 8, caracterizadopelo fato de que quando o polipeptídeo é pelo menos 60 % homólogo à SEQID 1, a proteína é uma proteína VPR, quando o polipeptídeo é pelo menos 60% homólogo à SEQ ID 2, a proteína é uma proteína VIF, quando opolipeptídeo é pelo menos 60 % homólogo à SEQ ID 3, a proteína é umaproteína REV, e quando o polipeptídeo é pelo menos 60 % homólogo à SEQID 4, a proteína é uma proteína NEF.

10. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que a homologia é de-75 % ou mais.

11. Polipeptídeo de acordo com a reivindicação 9,caracterizado pelo fato de que a homologia é de 85 % ou mais.

12. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que a homologia ésubstancialmente de 100 %.

13. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que o epítopocompreende 8, 9, 10 ou 11 aminoácidos ou mais.

14. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que não tem mais doque 50 resíduos de aminoácido.

15. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que compreende de 15a 45 resíduos de aminoácido.

16. Polipeptídeo imunogênico de epítopo múltiplo,caracterizado pelo fato de que compreende dois ou mais polipeptídeos comodefinidos em qualquer uma das reivindicações precedentes.

17. Composição de polipeptídeo, caracterizada pelo fato deque compreende dois ou mais polipeptídeos como definidos em qualquer umadas reivindicações precedentes.

18. Composição de polipeptídeo de acordo com areivindicação 17, caracterizada pelo fato de que os polipeptídeos tendo asseqüências das SEQ ID 1 a 4 são todos presentes.

19. Polipeptídeo de acordo com qualquer uma dasreivindicações precedentes, caracterizado pelo fato de que é para o uso namedicina.

20. Método para produzir um polipeptídeo como definido emqualquer uma das reivindicações precedentes, caracterizado pelo fato de quecompreende combinar dois ou mais epítopos para formar o polipeptídeo.

21. Construção de polipeptídeo, caracterizada pelo fato de quecompreende um polipeptídeo como definido em qualquer uma dasreivindicações precedentes e um carreador.

22. Método para produzir uma construção de polipeptídeocomo definida na reivindicação 21, caracterizado pelo fato de quecompreende combinar dois ou mais epítopos e/ou um polipeptídeo com ocarreador.

23. Construção de polipeptídeo ou um método de acordo comas reivindicações 21 ou 22, caracterizada pelo fato de que o carreador é umamolécula.

24. Construção de polipeptídeo ou um método de acordo comas reivindicações 22 ou 23, caracterizada pelo fato de que o carreadorcompreende um adjuvante e/ou um excipiente.

25. Composição de vacina ou medicamento contra um vírusHIV, caracterizada pelo fato de que compreende um polipeptídeo oucomposição de polipeptídeo como definido(a) em qualquer uma dasreivindicações de 1 a 19, e um excipiente e/ou adjuvante apropriados.

26. Composição de vacina ou medicamento contra um vírusHIV, caracterizada pelo fato de que compreende uma construção depolipeptídeo como definida nas reivindicações 21, 23 ou 24 e opcionalmenteum excipiente e/ou adjuvante apropriados.

27. Método para produzir uma composição de vacina oumedicamento como definida nas reivindicações 25 ou 26, caracterizado pelofato de que compreende misturar um polipeptídeo como definido em qualqueruma das reivindicações de 1 a 19 com um excipiente e/ou adjuvanteapropriados.

28. Uso de um polipeptídeo, uma composição de polipeptídeo,uma construção de polipeptídeo ou uma composição de vacina oumedicamento como definido(a) em qualquer uma das reivindicações de 1 a- 19, 21 e 23 a 26, caracterizado pelo fato de ser na fabricação de ummedicamento ou vacina, eficaz no tratamento ou prevenção de um vírus HIV.

29. Método para tratar ou prevenir uma infecção por vírusHTV, caracterizado pelo fato de que compreende administrar um polipeptídeo,uma composição de polipeptídeo, uma construção de polipeptídeo, umacomposição de vacina ou medicamento, como definido(a) em qualquer umadas reivindicações de 1 a 19, 21 e 23 a 26 a um vertebrado.

30. Método de acordo com a reivindicação 29, caracterizadopelo fato de que o vertebrado é um ser humano.