BRPI0707870A2 - ariltienopirimidinonas substituÍdas com amino Álcool, processo para sua preparaÇço e seu uso como medicamentos - Google Patents
ariltienopirimidinonas substituÍdas com amino Álcool, processo para sua preparaÇço e seu uso como medicamentos Download PDFInfo
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- BRPI0707870A2 BRPI0707870A2 BRPI0707870-6A BRPI0707870A BRPI0707870A2 BR PI0707870 A2 BRPI0707870 A2 BR PI0707870A2 BR PI0707870 A BRPI0707870 A BR PI0707870A BR PI0707870 A2 BRPI0707870 A2 BR PI0707870A2
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- Prior art keywords
- alkyl
- formula
- alkoxy
- independently
- hydroxy
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- 238000000034 method Methods 0.000 title claims abstract description 172
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- 229940079593 drug Drugs 0.000 title claims abstract description 17
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006007049 | 2006-02-15 | ||
| DE102006007049.6 | 2006-02-15 | ||
| PCT/EP2007/001213 WO2007093365A2 (en) | 2006-02-15 | 2007-02-13 | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0707870A2 true BRPI0707870A2 (pt) | 2011-05-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0707870-6A BRPI0707870A2 (pt) | 2006-02-15 | 2007-02-13 | ariltienopirimidinonas substituÍdas com amino Álcool, processo para sua preparaÇço e seu uso como medicamentos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8853208B2 (https=) |
| EP (1) | EP1987042B1 (https=) |
| JP (1) | JP2009526794A (https=) |
| KR (1) | KR20080096670A (https=) |
| CN (1) | CN101384605A (https=) |
| AR (1) | AR059520A1 (https=) |
| AU (1) | AU2007214710A1 (https=) |
| BR (1) | BRPI0707870A2 (https=) |
| CA (1) | CA2636879A1 (https=) |
| IL (1) | IL193342A0 (https=) |
| TW (1) | TW200801022A (https=) |
| UY (1) | UY30164A1 (https=) |
| WO (1) | WO2007093365A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2018380T3 (pl) * | 2006-05-19 | 2012-05-31 | Abbvie Bahamas Ltd | Skondensowane azabicykliczne pochodne alkanowe podstawione bicykloheterocyklem o aktywności wobec OUN |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| AU2010276441B2 (en) * | 2009-07-21 | 2015-07-02 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| WO2011031669A1 (en) | 2009-09-09 | 2011-03-17 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| US8524764B2 (en) | 2010-01-15 | 2013-09-03 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| MX2012008211A (es) | 2010-01-15 | 2012-08-08 | Gilead Sciences Inc | Inhibidores de virus flaviviridae. |
| HUP1100241A3 (en) | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
| PT2734515E (pt) | 2011-07-13 | 2016-03-11 | Gilead Sciences Inc | Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae |
| US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| SG11201804901WA (en) | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| EA201992780A1 (ru) | 2017-06-21 | 2020-06-02 | ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи | Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания |
| US12391705B2 (en) | 2018-12-19 | 2025-08-19 | Shy Therapeutics, Llc | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
| AU2002360387B2 (en) * | 2001-11-13 | 2008-08-07 | Emisphere Technologies, Inc. | Phenoxy amine compounds and compositions for delivering active agents |
| DE10233817A1 (de) * | 2002-07-25 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10238865A1 (de) * | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| AU2003287880A1 (en) * | 2002-12-11 | 2004-06-30 | 7Tm Pharma A/S | Cyclic quinoline compounds for use in mch receptor related disorders |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP2007509158A (ja) * | 2003-10-23 | 2007-04-12 | グラクソ グループ リミテッド | 肥満、糖尿病、うつ病及び不安を治療するためのｍｃｈｒ１アンタゴニストとしての３−（４−アミノフェニル）チエノピリミド−４−オン誘導体 |
| CN1930126A (zh) * | 2004-03-05 | 2007-03-14 | 万有制药株式会社 | 吡啶酮衍生物 |
| WO2005103039A1 (en) * | 2004-04-15 | 2005-11-03 | Neurocrine Biosciences, Inc. | 2- (3-aminopyrrolidin-1-yl) pyridines as melanin-concentrating hormone receptor an tagonists |
-
2007
- 2007-02-13 WO PCT/EP2007/001213 patent/WO2007093365A2/en not_active Ceased
- 2007-02-13 EP EP07711519.4A patent/EP1987042B1/en not_active Not-in-force
- 2007-02-13 KR KR1020087020095A patent/KR20080096670A/ko not_active Withdrawn
- 2007-02-13 TW TW096105357A patent/TW200801022A/zh unknown
- 2007-02-13 CN CNA2007800056310A patent/CN101384605A/zh active Pending
- 2007-02-13 CA CA002636879A patent/CA2636879A1/en not_active Abandoned
- 2007-02-13 JP JP2008554654A patent/JP2009526794A/ja active Pending
- 2007-02-13 AU AU2007214710A patent/AU2007214710A1/en not_active Abandoned
- 2007-02-13 BR BRPI0707870-6A patent/BRPI0707870A2/pt not_active IP Right Cessation
- 2007-02-15 AR ARP070100659A patent/AR059520A1/es not_active Application Discontinuation
- 2007-02-15 UY UY30164A patent/UY30164A1/es unknown
-
2008
- 2008-08-10 IL IL193342A patent/IL193342A0/en unknown
- 2008-08-14 US US12/191,678 patent/US8853208B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1987042A2 (en) | 2008-11-05 |
| EP1987042B1 (en) | 2015-01-21 |
| CN101384605A (zh) | 2009-03-11 |
| IL193342A0 (en) | 2009-05-04 |
| TW200801022A (en) | 2008-01-01 |
| US8853208B2 (en) | 2014-10-07 |
| JP2009526794A (ja) | 2009-07-23 |
| CA2636879A1 (en) | 2007-08-23 |
| WO2007093365A3 (en) | 2007-10-04 |
| AR059520A1 (es) | 2008-04-09 |
| WO2007093365A2 (en) | 2007-08-23 |
| US20090076002A1 (en) | 2009-03-19 |
| UY30164A1 (es) | 2007-09-28 |
| KR20080096670A (ko) | 2008-10-31 |
| AU2007214710A1 (en) | 2007-08-23 |
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Legal Events
| Date | Code | Title | Description |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |