BRPI0519839A2 - derivados do ácido 1h-indol-3-carboxìlico e seu uso como agonistas de ppar - Google Patents

derivados do ácido 1h-indol-3-carboxìlico e seu uso como agonistas de ppar

Info

Publication number
BRPI0519839A2
BRPI0519839A2 BRPI0519839-9A BRPI0519839A BRPI0519839A2 BR PI0519839 A2 BRPI0519839 A2 BR PI0519839A2 BR PI0519839 A BRPI0519839 A BR PI0519839A BR PI0519839 A2 BRPI0519839 A2 BR PI0519839A2
Authority
BR
Brazil
Prior art keywords
indole
carboxylic acid
acid derivatives
ppar agonists
compounds
Prior art date
Application number
BRPI0519839-9A
Other languages
English (en)
Inventor
Nathalie Adje
Stephane Yvon
Didier Roche
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0519839A2 publication Critical patent/BRPI0519839A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DO áCIDO 1 H-INDOL-3-CARBO-XìLICO E SEU USO COMO AGONISTAS DE PPAR. A presente invenção refere-se a compostos de fórmula (1), no qual A, R¹, R² e R³ são como definidos na descrição, em que os processos para a preparação desses compostos, os usos dos mesmos no trata- mento de dislipidemia, arteriosclerose e diabetes e as composições farma- cêuticas, compreendem os referidos compostos.
BRPI0519839-9A 2005-01-14 2005-12-17 derivados do ácido 1h-indol-3-carboxìlico e seu uso como agonistas de ppar BRPI0519839A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0500422A FR2880889B1 (fr) 2005-01-14 2005-01-14 Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
PCT/EP2005/013634 WO2006074789A1 (en) 2005-01-14 2005-12-17 1h-indole-3-carboxylic acid derivatives and their use as ppar agonists

Publications (1)

Publication Number Publication Date
BRPI0519839A2 true BRPI0519839A2 (pt) 2009-03-17

Family

ID=34953245

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519839-9A BRPI0519839A2 (pt) 2005-01-14 2005-12-17 derivados do ácido 1h-indol-3-carboxìlico e seu uso como agonistas de ppar

Country Status (15)

Country Link
US (1) US7754740B2 (pt)
EP (1) EP1836187B1 (pt)
JP (1) JP5042855B2 (pt)
KR (1) KR20070104353A (pt)
CN (1) CN101098865A (pt)
AT (1) ATE424394T1 (pt)
AU (1) AU2005324895B2 (pt)
BR (1) BRPI0519839A2 (pt)
CA (1) CA2594377C (pt)
DE (1) DE602005013118D1 (pt)
ES (1) ES2321745T3 (pt)
FR (1) FR2880889B1 (pt)
MX (1) MX2007008350A (pt)
WO (1) WO2006074789A1 (pt)
ZA (1) ZA200706707B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5281287B2 (ja) 2005-07-13 2013-09-04 Ｍｓｄ株式会社 ヘテロ環置換ベンズイミダゾール誘導体
CN103880730A (zh) * 2014-02-26 2014-06-25 南通大学 一种7-硝基吲哚-3-甲酸叔丁酯的化学合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1341761A1 (en) * 2000-10-10 2003-09-10 Smithkline Beecham Corporation SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS
WO2002046154A1 (en) * 2000-12-05 2002-06-13 Nippon Chemiphar Co., Ltd. Peroxisome proliferator activated receptor d activators
NZ547109A (en) * 2003-10-28 2010-03-26 Vertex Pharma Benzimidazoles useful as modulators of ion channels

Also Published As

Publication number Publication date
US20080114034A1 (en) 2008-05-15
ES2321745T3 (es) 2009-06-10
FR2880889A1 (fr) 2006-07-21
CA2594377C (en) 2014-02-18
ZA200706707B (en) 2008-09-25
JP5042855B2 (ja) 2012-10-03
AU2005324895A1 (en) 2006-07-20
DE602005013118D1 (de) 2009-04-16
US7754740B2 (en) 2010-07-13
CN101098865A (zh) 2008-01-02
ATE424394T1 (de) 2009-03-15
FR2880889B1 (fr) 2007-04-06
WO2006074789A1 (en) 2006-07-20
CA2594377A1 (en) 2006-07-20
KR20070104353A (ko) 2007-10-25
EP1836187A1 (en) 2007-09-26
JP2008526902A (ja) 2008-07-24
MX2007008350A (es) 2007-07-25
AU2005324895B2 (en) 2011-08-04
EP1836187B1 (en) 2009-03-04

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]