BRPI0516955A - ensaio genÈmico - Google Patents

ensaio genÈmico

Info

Publication number
BRPI0516955A
BRPI0516955A BRPI0516955-0A BRPI0516955A BRPI0516955A BR PI0516955 A BRPI0516955 A BR PI0516955A BR PI0516955 A BRPI0516955 A BR PI0516955A BR PI0516955 A BRPI0516955 A BR PI0516955A
Authority
BR
Brazil
Prior art keywords
nucleic acid
acid sequence
probe
providing
markers
Prior art date
Application number
BRPI0516955-0A
Other languages
English (en)
Inventor
Glen H Erikson
Jasmine I Daksis
Original Assignee
Ingeneus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ingeneus Inc filed Critical Ingeneus Inc
Publication of BRPI0516955A publication Critical patent/BRPI0516955A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Abstract

ENSAIO GENÈMICO. Trata-se de um método para detectar uma seqüência de ácido nuclélco em uma amostra genómica que inclui: proporcionar a amostra genómica que contém uma seqúência de ácido nucléico alvo de um ácido nucléico dúplex; proporcionar uma sonda que contém uma seqúência de ácido nucléico de sonda; proporcionar uma mistura de hibridização; irradiar a mistura incubada com radiação eficaz para estimular pelo menos alguns dos marcadores a emitir energia; e detectar a partir de um sinal fluorescente se a sonda se emparelha perfeitamente na seqúência de ácido nucléico alvo, onde a detecção é realizada dentro de sessenta minutos da mistura de hibridização proporcionada, e o método é realizado sem desnaturação e sem amplificação por PCR do ácido nucléico dúplex. Um kit para praticar o método inclui a sonda, o agente promotor de hibridização, e marcadores.
BRPI0516955-0A 2004-09-24 2005-09-23 ensaio genÈmico BRPI0516955A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61267004P 2004-09-24 2004-09-24
PCT/IB2005/053162 WO2006033088A2 (en) 2004-09-24 2005-09-23 Genomic assay

Publications (1)

Publication Number Publication Date
BRPI0516955A true BRPI0516955A (pt) 2008-09-30

Family

ID=36000782

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516955-0A BRPI0516955A (pt) 2004-09-24 2005-09-23 ensaio genÈmico

Country Status (14)

Country Link
US (1) US8486622B2 (pt)
EP (1) EP1815010A2 (pt)
JP (1) JP2008514197A (pt)
KR (1) KR20070062575A (pt)
CN (1) CN101031659A (pt)
AU (1) AU2005286084C1 (pt)
BR (1) BRPI0516955A (pt)
CA (1) CA2581087C (pt)
IL (1) IL182107A0 (pt)
NZ (1) NZ554538A (pt)
RU (1) RU2464320C2 (pt)
SG (1) SG155995A1 (pt)
WO (1) WO2006033088A2 (pt)
ZA (1) ZA200703326B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE526975T1 (de) 2005-10-07 2011-10-15 California Inst Of Techn Pkr-aktivierung mittels hybridisierungskettenreaktion
EP2155770B1 (en) * 2007-05-16 2013-10-16 California Institute of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
US20100021904A1 (en) * 2008-05-21 2010-01-28 Pierce Niles A Shielded cross-linking probes
US20100021901A1 (en) * 2008-05-22 2010-01-28 Peng Yin Compositions and methods for detecting analytes
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
US8962241B2 (en) * 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US8980553B2 (en) * 2011-04-02 2015-03-17 New England Biolabs, Inc. Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides
US9145580B2 (en) * 2011-04-02 2015-09-29 New England Biolabs, Inc. Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides
EP2832863A4 (en) * 2012-03-29 2016-02-24 Mitsubishi Rayon Co MICROARRAY FOR THE DETECTION OF MUTATIONS IN BETA-GLOBIN GENES AND PROOF PROCESS THEREFOR
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
WO2015038817A1 (en) * 2013-09-11 2015-03-19 Celexion Llc High throughput screening for biomolecules
JP6300263B2 (ja) * 2013-09-25 2018-03-28 学校法人甲南学園 核酸鎖の四重螺旋構造の検出方法
RU2577107C2 (ru) * 2013-10-04 2016-03-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ поиска белков-мишеней, запускающих процесс канцерогенеза, в образцах тканей индивидуального пациента, для последующей противоопухолевой фармакотерапии
WO2017070693A1 (en) * 2015-10-23 2017-04-27 University Of Utah Research Foundation Methods and systems for detecting variations in dna
KR102110985B1 (ko) * 2015-12-15 2020-05-14 주식회사 씨젠 타겟 핵산 서열에 대한 시그널 추출
WO2017131463A1 (en) * 2016-01-26 2017-08-03 Seegene, Inc. . Methods for providing signal for target nucleic acid sequence
RU2637310C1 (ru) * 2016-06-08 2017-12-04 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Флуоресцентно-меченые дезоксиуридинтрифосфаты
DK3481843T3 (en) 2016-07-05 2022-02-07 California Inst Of Techn Fractional initiator hybridization chain reaction
CA3034617A1 (en) 2016-08-30 2018-03-08 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
CN110546273A (zh) * 2017-03-30 2019-12-06 生命技术公司 通过衔接子序列定量ngs dna
CN112162027B (zh) * 2020-09-21 2023-08-18 上海市计量测试技术研究院 一种基于三嵌段探针的电化学传感器及其在检测转基因双链rna中的应用
EP4284925A1 (en) 2021-01-26 2023-12-06 California Institute of Technology Allosteric conditional guide rnas for cell-selective regulation of crispr/cas

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4761379A (en) * 1984-08-09 1988-08-02 Becton, Dickinson And Company Biological specimen collection device
US4883867A (en) 1985-11-01 1989-11-28 Becton, Dickinson And Company Detection of reticulocytes, RNA or DNA
US5599667A (en) 1987-03-02 1997-02-04 Gen-Probe Incorporated Polycationic supports and nucleic acid purification separation and hybridization
US6147198A (en) 1988-09-15 2000-11-14 New York University Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
US5720928A (en) 1988-09-15 1998-02-24 New York University Image processing and analysis of individual nucleic acid molecules
FR2641692A1 (fr) * 1989-01-17 1990-07-20 Nippon Zeon Co Bouchon de fermeture d'une breche pour application medicale et dispositif pour bouchon de fermeture l'utilisant
EP0605655B1 (en) 1991-09-16 1997-05-07 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
US5354309A (en) * 1991-10-11 1994-10-11 Angiomed Ag Apparatus for widening a stenosis in a body cavity
CA2380683C (en) * 1991-10-28 2006-08-08 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
DE69233391D1 (de) 1991-11-07 2004-09-02 Nanotronics Inc Hybridisierung von mit Chromophoren und Fluorophoren konjugierten Polynukleotiden zur Erzeugung eines Donor-Donor Energietransfersystems
US5321130A (en) 1992-02-10 1994-06-14 Molecular Probes, Inc. Unsymmetrical cyanine dyes with a cationic side chain
US5342387A (en) * 1992-06-18 1994-08-30 American Biomed, Inc. Artificial support for a blood vessel
EP0599337B1 (en) 1992-11-27 2006-03-08 Canon Kabushiki Kaisha Method for detection of nucleic acid and probe therefor
US5410030A (en) 1993-04-05 1995-04-25 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes containing pyridinium moieties
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5609628A (en) * 1995-04-20 1997-03-11 Keranen; Victor J. Intravascular graft and catheter
US5766192A (en) * 1995-10-20 1998-06-16 Zacca; Nadim M. Atherectomy, angioplasty and stent method and apparatus
WO1997015691A1 (en) 1995-10-27 1997-05-01 Ramberg Elliot R Methods and compositions for detection of specific nucleotide sequences
US6168622B1 (en) * 1996-01-24 2001-01-02 Microvena Corporation Method and apparatus for occluding aneurysms
US5853422A (en) * 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
IL126544A (en) 1996-04-25 2004-08-31 Genicon Sciences Inc Test for component detection using detectable particles in diffused light
US5741297A (en) * 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US6007573A (en) * 1996-09-18 1999-12-28 Microtherapeutics, Inc. Intracranial stent and method of use
GB2333597B (en) * 1996-10-29 2001-04-18 Univ Nebraska At Lincoln Method for detecting point mutations in dna utilizing fluorescence energy transfer
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US6783932B2 (en) 1997-01-02 2004-08-31 Princeton University Stabilization of triplexes by water structure-making substances
US6251591B1 (en) 1997-02-27 2001-06-26 Lorne Park Research, Inc. Quantitative method for detecting nucleotide concentration
US6060242A (en) 1997-02-27 2000-05-09 Lorne Park Research, Inc. PNA diagnostic methods
US6046004A (en) 1997-02-27 2000-04-04 Lorne Park Research, Inc. Solution hybridization of nucleic acids with antisense probes having modified backbones
US5846729A (en) 1997-02-27 1998-12-08 Lorne Park Research, Inc. Assaying nucleotides in solution using a fluorescent intensity quenching effect
US5980554A (en) * 1997-05-05 1999-11-09 Micro Therapeutics, Inc. Wire frame partial flow obstruction for aneurysm treatment
US5951599A (en) * 1997-07-09 1999-09-14 Scimed Life Systems, Inc. Occlusion system for endovascular treatment of an aneurysm
US5928260A (en) * 1997-07-10 1999-07-27 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
GB9715241D0 (en) * 1997-07-18 1997-09-24 Jeffree Martin A Device for treating aneurysms
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US6683173B2 (en) 1998-04-03 2004-01-27 Epoch Biosciences, Inc. Tm leveling methods
US6255050B1 (en) 1998-05-22 2001-07-03 Lorne Park Research, Inc. Dynamic hybridization system
AU756080B2 (en) * 1998-06-04 2003-01-02 New York University Endovascular thin film devices and methods for treating and preventing stroke
US6139564A (en) * 1998-06-16 2000-10-31 Target Therapeutics Inc. Minimally occlusive flow disruptor stent for bridging aneurysm necks
US6656218B1 (en) * 1998-07-24 2003-12-02 Micrus Corporation Intravascular flow modifier and reinforcement device
US6093199A (en) * 1998-08-05 2000-07-25 Endovascular Technologies, Inc. Intra-luminal device for treatment of body cavities and lumens and method of use
JP2000196906A (ja) * 1998-10-22 2000-07-14 Xerox Corp プリントシステム及び方法
US6656692B2 (en) * 1999-12-21 2003-12-02 Ingeneus Corporation Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
US6900300B1 (en) 2000-09-19 2005-05-31 Ingeneus Corporation Quadruplex DNA and duplex probe systems
US6294333B1 (en) 1998-12-31 2001-09-25 Ingeneus Corp. Fluorescent intensity assay for protein or peptide binding to nucleic acids
US6858390B2 (en) 1998-12-31 2005-02-22 Ingeneus Corporation Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes
US6420115B1 (en) * 1999-12-21 2002-07-16 Ingeneus Corporation Cation mediated triplex hybridization assay
US6403313B1 (en) * 1999-12-21 2002-06-11 Ingeneus Corporation Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators
US6231597B1 (en) * 1999-02-16 2001-05-15 Mark E. Deem Apparatus and methods for selectively stenting a portion of a vessel wall
US6153389A (en) 1999-02-22 2000-11-28 Haarer; Brian K. DNA additives as a mechanism for unambiguously marking biological samples
US6712836B1 (en) * 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US6375668B1 (en) * 1999-06-02 2002-04-23 Hanson S. Gifford Devices and methods for treating vascular malformations
US6645733B1 (en) 1999-06-25 2003-11-11 Ingeneus Corporation Fluorescent intensity method for assaying binding between proteins or peptides
JP2001061968A (ja) * 1999-08-30 2001-03-13 Hiroshi Terai 動脈瘤治療具
US6551303B1 (en) * 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US20040081959A9 (en) 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US6924108B2 (en) * 1999-12-21 2005-08-02 Ingeneus Corporation Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
US6927027B2 (en) 1999-12-21 2005-08-09 Ingeneus Corporation Nucleic acid multiplex formation
US20030181412A1 (en) 1999-12-21 2003-09-25 Ingeneus Corporation Method for modifying transcription and/or translation in an organism for therapeutic, prophylactic and/or analytic uses
US7309569B2 (en) * 1999-12-21 2007-12-18 Ingeneus, Inc. Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
US6911536B1 (en) * 1999-12-21 2005-06-28 Ingeneus Corporation Triplex and quadruplex catalytic hybridization
US7052844B2 (en) * 1999-12-21 2006-05-30 Ingeneus, Inc. Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism
US20030170659A1 (en) * 2000-01-24 2003-09-11 Ingeneus Corporation Electrical treatment of binding media to encourage, discourage and/or study biopolymer binding
US6613524B1 (en) 2000-01-24 2003-09-02 Ingeneus Corporation Amperometric affinity assay and electrically stimulated complexes of nucleic acids
US6265170B1 (en) * 2000-01-24 2001-07-24 Ingeneus Corporation Homogenous assay of duplex of triplex hybridization by means of multiple measurements under varied conditions
US7220541B2 (en) 2000-01-24 2007-05-22 Ingeneus, Inc. Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
US6982147B2 (en) 2000-01-24 2006-01-03 Ingeneus Corporation Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
AU2001238389B2 (en) * 2000-02-16 2006-09-21 Illumina, Inc. Parallel genotyping of multiple patient samples
US6391037B1 (en) * 2000-03-02 2002-05-21 Prodesco, Inc. Bag for use in the intravascular treatment of saccular aneurysms
US6648911B1 (en) * 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US6936433B2 (en) 2000-11-27 2005-08-30 The Regents Of The University Of California Methods and devices for characterizing duplex nucleic acid molecules
US20020173838A1 (en) * 2001-05-18 2002-11-21 Frazier O. Howard Method and apparatus for surgically restoring coronary blood vessels
US6454780B1 (en) * 2001-06-21 2002-09-24 Scimed Life Systems, Inc. Aneurysm neck obstruction device
US8715312B2 (en) * 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US6617137B2 (en) 2001-10-15 2003-09-09 Molecular Staging Inc. Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US7273699B2 (en) 2002-01-31 2007-09-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for detecting nucleic acid sequence variation
US20030171801A1 (en) * 2002-03-06 2003-09-11 Brian Bates Partially covered intraluminal support device
US20030204244A1 (en) * 2002-04-26 2003-10-30 Stiger Mark L. Aneurysm exclusion stent
US20040034386A1 (en) * 2002-08-19 2004-02-19 Michael Fulton Aneurysm stent
US7157228B2 (en) * 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
JP2004187604A (ja) * 2002-12-12 2004-07-08 Fuji Photo Film Co Ltd 遺伝子発現量の分析方法
US20050165469A1 (en) * 2002-12-24 2005-07-28 Michael Hogendijk Vascular prosthesis including torsional stabilizer and methods of use
US20040142329A1 (en) * 2003-01-17 2004-07-22 Ingeneus Corporation Probe conjugation to increase multiplex binding motif preference
US20040180345A1 (en) 2003-03-14 2004-09-16 Ingeneus Corporation Pre-incubation method to improve signal/noise ratio of nucleic acid assays
EP2191790A3 (en) * 2003-05-19 2012-10-17 SeptRx, Inc. Tissue distention device and related methods for therapeutic intervention
AU2003272255A1 (en) * 2003-09-02 2005-04-06 University Of Florida Polymeric reconstrainable, repositionable, detachable, percutaneous endovascular stentgraft
US8157855B2 (en) * 2003-12-05 2012-04-17 Boston Scientific Scimed, Inc. Detachable segment stent
US20060004438A1 (en) * 2004-04-30 2006-01-05 Novostent Corporation Prosthesis, delivery system and method for neurovascular aneurysm repair
US20060206200A1 (en) * 2004-05-25 2006-09-14 Chestnut Medical Technologies, Inc. Flexible vascular occluding device
US20060098833A1 (en) * 2004-05-28 2006-05-11 Juneau Roger P Self forming in-the-ear hearing aid
WO2006055052A2 (en) * 2004-07-19 2006-05-26 Michael Gertner Methods and devices for chronic embolic protection
CA2581272A1 (en) * 2004-09-22 2006-05-18 Lee R. Guterman Cranial aneurysm treatment arrangement
US20060155323A1 (en) * 2005-01-07 2006-07-13 Porter Stephen C Intra-aneurysm devices
US7306623B2 (en) * 2005-01-13 2007-12-11 Medtronic Vascular, Inc. Branch vessel graft design and deployment method

Also Published As

Publication number Publication date
WO2006033088A3 (en) 2006-07-06
AU2005286084A1 (en) 2006-03-30
RU2464320C2 (ru) 2012-10-20
CA2581087A1 (en) 2006-03-30
JP2008514197A (ja) 2008-05-08
ZA200703326B (en) 2008-11-26
RU2007115421A (ru) 2008-10-27
US8486622B2 (en) 2013-07-16
AU2005286084B2 (en) 2011-04-28
NZ554538A (en) 2009-12-24
KR20070062575A (ko) 2007-06-15
AU2005286084C1 (en) 2011-11-24
CA2581087C (en) 2013-11-19
EP1815010A2 (en) 2007-08-08
IL182107A0 (en) 2007-07-24
SG155995A1 (en) 2009-10-29
WO2006033088A2 (en) 2006-03-30
CN101031659A (zh) 2007-09-05
US20090123914A1 (en) 2009-05-14

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