BRPI0513504A - variantes de alérgenos do grupo 1 de poaceae tendo reduzida alergenicidade e reatividade de células t mantida - Google Patents

variantes de alérgenos do grupo 1 de poaceae tendo reduzida alergenicidade e reatividade de células t mantida

Info

Publication number
BRPI0513504A
BRPI0513504A BRPI0513504-4A BRPI0513504A BRPI0513504A BR PI0513504 A BRPI0513504 A BR PI0513504A BR PI0513504 A BRPI0513504 A BR PI0513504A BR PI0513504 A BRPI0513504 A BR PI0513504A
Authority
BR
Brazil
Prior art keywords
variants
maintained
reactivity
allergen variants
poaceae
Prior art date
Application number
BRPI0513504-4A
Other languages
English (en)
Inventor
Helmut Fiebig
Martin Wald
Andreas Nandy
Helga Kahlert
Bernhard Weber
Oliver Cromwell
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0513504A publication Critical patent/BRPI0513504A/pt
Publication of BRPI0513504B1 publication Critical patent/BRPI0513504B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

VARIANTES DE ALéRGENOS DO GRUPO 1 DE POACEAE TENDO REDUZIDA ALERGENICIDADE E REATIVIDADE DE CéLULAS T MANTIDA. A presente invenção refere-se à preparação e aplicação de variantes dos alérgenos do grupo 1 das Poaceae (capins-doces) as quais se caracterizam por reduzida reatividade a IgE comparados com os alérgenos selvagens conhecidos e ao mesmo tempo por reatividade essencialmente mantida com linfócitos T. Estas variantes de alérgenos hipoalergênicas podem ser empregadas para a imunoterapia específica (hipossensibilização) de pacientes tendo alergia a pólen de capim ou para a imunoterapia preventiva de alergias a pólen de capim.
BRPI0513504A 2004-07-21 2005-07-11 variantes de phl p 1, seu processo de preparação, vetor, moléculas de dna, seus usos, composições farmacêuticas, e organismo procariótico BRPI0513504B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004035337A DE102004035337A1 (de) 2004-07-21 2004-07-21 Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität
PCT/EP2005/007481 WO2006008018A1 (de) 2004-07-21 2005-07-11 Varianten der gruppe 1-allergene aus poaceae mit reduzierter allergenität und erhaltener t-zellreaktivität

Publications (2)

Publication Number Publication Date
BRPI0513504A true BRPI0513504A (pt) 2008-05-06
BRPI0513504B1 BRPI0513504B1 (pt) 2016-08-16

Family

ID=35106807

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513504A BRPI0513504B1 (pt) 2004-07-21 2005-07-11 variantes de phl p 1, seu processo de preparação, vetor, moléculas de dna, seus usos, composições farmacêuticas, e organismo procariótico

Country Status (13)

Country Link
US (1) US8263090B2 (pt)
EP (2) EP2028189A3 (pt)
JP (1) JP5149002B2 (pt)
CN (2) CN1989151B (pt)
AT (1) ATE432944T1 (pt)
AU (1) AU2005263477B2 (pt)
BR (1) BRPI0513504B1 (pt)
CA (2) CA2903726A1 (pt)
DE (2) DE102004035337A1 (pt)
ES (1) ES2328050T3 (pt)
PT (1) PT1768996E (pt)
RU (1) RU2409589C2 (pt)
WO (1) WO2006008018A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
CN102307893B (zh) * 2009-02-05 2014-03-26 切尔卡西亚有限公司 用于疫苗的草肽
EP2523684A1 (de) * 2010-01-14 2012-11-21 Merck Patent GmbH Varianten der gruppe 6-allergene der süssgräser mit reduzierter allergenität durch mutagenese von prolinresten
CN108728450B (zh) * 2018-06-11 2021-06-01 中国科学院武汉植物园 狗牙根中一个受低温显著诱导的基因CdERF1及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4012095A (en) * 1994-10-25 1996-05-15 United Biomedical Inc. Synthetic ige membrane anchor peptide immunogens for the treatment of allergy
AR020102A1 (es) * 1998-07-30 2002-04-10 Ucb Sa Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento
AUPR779201A0 (en) 2001-09-20 2001-10-11 University Of Melbourne, The Immunotherapeutic and immunoprophylactic reagents
ES2400181T3 (es) * 2002-08-19 2013-04-08 Merck Patent Gmbh Variantes del alérgeno mayor PHI P 1 de hierba timotea

Also Published As

Publication number Publication date
DE102004035337A1 (de) 2006-03-16
CA2903726A1 (en) 2006-01-26
BRPI0513504B1 (pt) 2016-08-16
JP5149002B2 (ja) 2013-02-20
EP2028189A2 (de) 2009-02-25
CA2574449C (en) 2015-12-01
CN103467583A (zh) 2013-12-25
JP2008507262A (ja) 2008-03-13
CA2574449A1 (en) 2006-01-26
WO2006008018A1 (de) 2006-01-26
CN1989151A (zh) 2007-06-27
AU2005263477B2 (en) 2011-12-08
PT1768996E (pt) 2009-09-07
CN1989151B (zh) 2014-08-27
RU2409589C2 (ru) 2011-01-20
RU2007106170A (ru) 2008-08-27
DE502005007428D1 (de) 2009-07-16
EP1768996B1 (de) 2009-06-03
US8263090B2 (en) 2012-09-11
EP1768996A1 (de) 2007-04-04
EP2028189A3 (de) 2009-07-08
US20080267985A1 (en) 2008-10-30
AU2005263477A1 (en) 2006-01-26
ES2328050T3 (es) 2009-11-06
ATE432944T1 (de) 2009-06-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: REF. A RPI NO 2154 DE 17/04/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/08/2016, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 14A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2522 DE 07-05-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.