BRPI0513062A - composição farmacêutica, método de estimular a produção de pomc em um paciente, usos de um peptìdeo de crf isolado e de um peptìdeo de pomc isolado, e, métodos de tratamento para uma doença, de produzir crf e de tratamento curativo, melhorador ou profilático de uma doença - Google Patents

composição farmacêutica, método de estimular a produção de pomc em um paciente, usos de um peptìdeo de crf isolado e de um peptìdeo de pomc isolado, e, métodos de tratamento para uma doença, de produzir crf e de tratamento curativo, melhorador ou profilático de uma doença

Info

Publication number
BRPI0513062A
BRPI0513062A BRPI0513062-0A BRPI0513062A BRPI0513062A BR PI0513062 A BRPI0513062 A BR PI0513062A BR PI0513062 A BRPI0513062 A BR PI0513062A BR PI0513062 A BRPI0513062 A BR PI0513062A
Authority
BR
Brazil
Prior art keywords
crf
pomc
isolated
disease
peptide
Prior art date
Application number
BRPI0513062-0A
Other languages
English (en)
Inventor
Deirdre Mclntosh
Original Assignee
Aimsco Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0415359.9A external-priority patent/GB0415359D0/en
Application filed by Aimsco Ltd filed Critical Aimsco Ltd
Publication of BRPI0513062A publication Critical patent/BRPI0513062A/pt

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/34—Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/35—Corticotropin [ACTH]
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)

Abstract

COMPOSIçãO FARMACêUTICA, MéTODO DE ESTIMULAR A PRODUçãO DE POMC EM UM PACIENTE, USOS DE UM PEPTìDEO DE CRF ISOLADO E DE UM PEPTìDEO DE POMC ISOLADO, E, MéTODOS DE TRATAMENTO PARA UMA DOENçA, DE PRODUZIR CRF E DE TRATAMENTO CURATIVO, MELHORADOR OU PROFILáTICO DE UMA DOENçA Descreve-se a análise de um produto de soro de cabra com muitos efeitos terapêuticos. O produto é identifiicado como contendo proopiomelanocortina (POMC) e os peptídeos do fator de liberação da corticotropina (CRF), bem como produtos de decomposição destes peptídeos. Descrevemos métodos de tratamento de doenças, incluindo cânceres, esclerose múltipla e distúrbios neurais, com o uso destes peptídeos e seus produtos, bem como medicamentos incluindo tais peptídeos, e métodos de produzir os peptídeos.
BRPI0513062-0A 2004-07-08 2005-07-08 composição farmacêutica, método de estimular a produção de pomc em um paciente, usos de um peptìdeo de crf isolado e de um peptìdeo de pomc isolado, e, métodos de tratamento para uma doença, de produzir crf e de tratamento curativo, melhorador ou profilático de uma doença BRPI0513062A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0415359.9A GB0415359D0 (en) 2004-07-08 2004-07-08 Medicament
GBGB0423386.2A GB0423386D0 (en) 2004-07-08 2004-10-21 Medicament
PCT/GB2005/050108 WO2006021814A2 (en) 2004-07-08 2005-07-08 Medicament

Publications (1)

Publication Number Publication Date
BRPI0513062A true BRPI0513062A (pt) 2008-04-22

Family

ID=35967903

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513062-0A BRPI0513062A (pt) 2004-07-08 2005-07-08 composição farmacêutica, método de estimular a produção de pomc em um paciente, usos de um peptìdeo de crf isolado e de um peptìdeo de pomc isolado, e, métodos de tratamento para uma doença, de produzir crf e de tratamento curativo, melhorador ou profilático de uma doença

Country Status (7)

Country Link
EP (1) EP1765377A2 (pt)
JP (1) JP2008505878A (pt)
KR (1) KR101235723B1 (pt)
AU (1) AU2005276242B2 (pt)
BR (1) BRPI0513062A (pt)
CA (1) CA2572777A1 (pt)
WO (1) WO2006021814A2 (pt)

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GB0415359D0 (en) * 2004-07-08 2004-08-11 Aimsco Ltd Medicament
GB0509052D0 (en) * 2005-05-04 2005-06-08 Aimsco Ltd Combination therapy
GB0600202D0 (en) * 2006-01-06 2006-02-15 Aimsco Ltd Treatment of HIV
EP2081587A2 (en) 2006-10-18 2009-07-29 Research Development Foundation Alpha-msh therapies for treatment of autoimmune disease
WO2009043526A2 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
WO2009043520A1 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of grf-1 (1-29 ) and corticotropin-releasing factor as therapeutic agents
EP2187913B1 (en) * 2007-09-11 2012-07-11 Mondobiotech Laboratories AG Ac-RFMWMR-NH2 for use in the treatment of Mycobacterium tuberculosis related diseases
RU2010148803A (ru) * 2008-04-30 2012-06-10 Ньютрон Роу (Bm) Способы применения кортикотропин-рилизинг фактора для лечения рака
US20100203048A1 (en) 2008-04-30 2010-08-12 Stephen Evans-Freke Methods of using corticotropin-releasing factor for the use of the treatment of cancer
GB0910032D0 (en) * 2009-06-11 2009-07-22 Aimsco Ltd Use of serum composition to reduce the levels of TNF and/or VEGF in mammals
EP2568999B1 (en) * 2010-05-11 2018-07-11 Mallinckrodt Ard Ip Limited Acth for treatment of amyotrophic lateral sclerosis
CA2877562A1 (en) 2012-06-25 2014-01-03 Aimsco Limited Formulation comprising crh and alpha-2 macroglobulin
WO2015033175A1 (en) * 2013-09-06 2015-03-12 Zlatko Ademovic Combination of pro-opiomelanocortin endogenous peptides in autoimmune disease treatment
GB201322948D0 (en) * 2013-12-23 2014-02-12 Aimsco Ltd Improved formulation
ES2890677T3 (es) 2014-03-19 2022-01-21 Ionis Pharmaceuticals Inc Composiciones para modular la expresión de ataxina 2
US10006027B2 (en) 2014-03-19 2018-06-26 Ionis Pharmaceuticals, Inc. Methods for modulating Ataxin 2 expression
GB201617175D0 (en) 2016-10-10 2016-11-23 Iconic Intellectual Property Limited Assay
AU2019310097A1 (en) 2018-07-25 2021-02-04 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing ATXN2 expression
GB201911064D0 (en) 2019-08-02 2019-09-18 Tarian Biologics Ltd Therapy
GB201911063D0 (en) 2019-08-02 2019-09-18 Tarian Biologics Ltd Formulations
KR102551880B1 (ko) * 2020-11-13 2023-07-05 성균관대학교산학협력단 부신피질자극호르몬분비호르몬을 유효성분으로 포함하는 신경세포구 형성 촉진용 조성물

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US4801612A (en) * 1986-07-03 1989-01-31 Regents Of The University Of California Method of inhibiting inflammatory response
US5137871A (en) * 1989-07-28 1992-08-11 Regents Of The University Of California Treatment to reduce edema for brain and musculature injuries
US5547940A (en) * 1992-03-16 1996-08-20 Ludwig Institute For Cancer Research Method for stimulating proliferation of colon cells using POMC76-103
DE4407489A1 (de) * 1994-03-07 1995-09-14 Bayer Ag Vakzine zur Prävention von Respirations- und Reproduktionserkrankungen des Schweines
US20030186867A1 (en) * 2000-03-31 2003-10-02 Laura Facci Use of crf receptor agonists for the treatment or prophylaxis of diseases, for example neurodegenerative diseases
DE50201566D1 (de) * 2001-02-24 2004-12-23 Mologen Ag Beta-endorphin / crf - gentherapie zur lokalen schmerzbekämpfung
KR20040030786A (ko) * 2001-07-02 2004-04-09 아임스코 리미티드 폴리클론항체 항-hiv 산양 혈청의 치료제로의 용도
CA2473754C (en) * 2002-01-28 2012-04-10 Aimsco Limited Treatment of ms with goat serum

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Publication number Publication date
CA2572777A1 (en) 2006-03-02
AU2005276242B2 (en) 2011-08-25
JP2008505878A (ja) 2008-02-28
KR20070042546A (ko) 2007-04-23
KR101235723B1 (ko) 2013-02-21
WO2006021814A2 (en) 2006-03-02
WO2006021814A3 (en) 2007-03-29
AU2005276242A1 (en) 2006-03-02
EP1765377A2 (en) 2007-03-28

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