BRPI0512900A - composição farmacêutica compreendendo de ibuprofeno, processo de preparação dos gránulos enriquecidos em ibuprofeno e os gránulos secos feitos por este processo - Google Patents
composição farmacêutica compreendendo de ibuprofeno, processo de preparação dos gránulos enriquecidos em ibuprofeno e os gránulos secos feitos por este processoInfo
- Publication number
- BRPI0512900A BRPI0512900A BRPI0512900-1A BRPI0512900A BRPI0512900A BR PI0512900 A BRPI0512900 A BR PI0512900A BR PI0512900 A BRPI0512900 A BR PI0512900A BR PI0512900 A BRPI0512900 A BR PI0512900A
- Authority
- BR
- Brazil
- Prior art keywords
- granules
- ibuprofen
- fluidizing
- mixture
- super disintegrant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
COMPOSIçãO FARMACêUTICA COMPREENDENDO DE IBUPROFENO, PROCESSO DE PREPARAçãO DOS GRáNULOS ENRIQUECIDOS EM IBUPROFENO E OS GRáNULOS SECOS FEITOS POR ESTE PROCESSO. A presente invenção descreve grânulos composto de pelo menos uma quantidade substancial de ibuprofeno, pelo menos um super desintegrante aceitável farmaceuticamente e pelo menos um aglutinante aceitável farmaceuticamente, no qual o aglutinante e diferente do super desintegrante (s), onde o super desintegrante está substancialmente uniformemente dispersado por toda a parte dos grânulos. Os grânulos podem ser preparados pela (a) obtenção de uma mistura de ibuprofeno dividido finamente e pelo menos um super desintegrante farmaceuticamente aceitável dividido finamente; (b) fluidizando a mistura de a) com o agente fluidificante gasoso tal para desse modo, formar uma mistura seca substancialmente homogênea; (c) enquanto fluidiza-se a mistura seca homogênea formada em b) com o agente fluidificante gasoso aquecido, pulveriza-se sobre a mistura fluidizada uma solução aquosa, uma dispersão ou uma suspensão de pela menos um aglutinante para formar grânulos úmidos e (d) fluidizando-se os grânulos umidificados de o) com o agente fluidificante gasoso aquecido, para produzir as granules que têm um índice de umidade menor do que de 5 % p baseado no peso dos grânulos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58383904P | 2004-06-30 | 2004-06-30 | |
PCT/US2005/016833 WO2006007095A2 (en) | 2004-06-30 | 2005-05-13 | High ibuprofen content granules and their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0512900A true BRPI0512900A (pt) | 2008-04-15 |
Family
ID=34969553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0512900-1A BRPI0512900A (pt) | 2004-06-30 | 2005-05-13 | composição farmacêutica compreendendo de ibuprofeno, processo de preparação dos gránulos enriquecidos em ibuprofeno e os gránulos secos feitos por este processo |
Country Status (8)
Country | Link |
---|---|
US (1) | US8940329B2 (pt) |
EP (1) | EP1765296A2 (pt) |
JP (1) | JP2008505074A (pt) |
AR (1) | AR049117A1 (pt) |
BR (1) | BRPI0512900A (pt) |
CA (1) | CA2570524C (pt) |
MX (1) | MXPA06015027A (pt) |
WO (1) | WO2006007095A2 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT511671A1 (de) * | 2011-07-13 | 2013-01-15 | Bischof Georg Dr | Zusammensetzung zur erzeugung einer vorübergehenden okklusion des darms eines säugetiers |
CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
CN113318081A (zh) * | 2021-05-11 | 2021-08-31 | 哈尔滨华瑞生化药业有限责任公司 | 一种布洛芬颗粒及其制备方法 |
CN115581673B (zh) * | 2022-10-28 | 2024-02-02 | 浙江康恩贝制药股份有限公司 | 一种布洛芬颗粒及其制备方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
US4806359A (en) * | 1987-04-22 | 1989-02-21 | Mcneilab, Inc. | Iburprofen sustained release matrix and process |
US4904477A (en) * | 1987-07-08 | 1990-02-27 | American Home Products Corporation | Spray dried ibuprofen compositions |
IE61676B1 (en) * | 1987-07-08 | 1994-11-30 | American Home Prod | Spray dried ibuprofen composition |
US4837031A (en) * | 1987-09-17 | 1989-06-06 | Mallinckrodt, Inc. | Compositions containing ibuprofen |
US4911921A (en) * | 1989-02-02 | 1990-03-27 | Mallinckrodt, Inc. | High ibuprofen content granulations |
US5104648A (en) * | 1989-02-02 | 1992-04-14 | Mallinckrodt Specialty Chemicals Company | High ibuprofen content granulations |
CA2063141C (en) * | 1989-08-04 | 1997-03-04 | Edward J. Roche | Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets |
DK138592D0 (da) * | 1992-11-17 | 1992-11-17 | Nycomed Dak As | Tabletter |
US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
US6361794B1 (en) * | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
PE20020322A1 (es) * | 2000-08-18 | 2002-05-10 | Pharmacia Corp | Formulacion oral de rapida disolucion de un inhibidor de la ciclooxigenasa 2 |
US6387400B1 (en) | 2000-08-29 | 2002-05-14 | R.P. Scherer Technologies, Inc. | Process for preparing pharmaceutical compositions for use with soft gelatin formulations |
GB0108930D0 (en) * | 2001-04-10 | 2001-05-30 | Boots Co Plc | Therapeutic agents |
ATE504288T1 (de) * | 2003-09-26 | 2011-04-15 | Alza Corp | Oros-push-stick für die kontrollierte abgabe von wirkstoffen |
-
2005
- 2005-05-13 BR BRPI0512900-1A patent/BRPI0512900A/pt not_active IP Right Cessation
- 2005-05-13 EP EP05748306A patent/EP1765296A2/en not_active Withdrawn
- 2005-05-13 CA CA2570524A patent/CA2570524C/en not_active Expired - Fee Related
- 2005-05-13 JP JP2007519208A patent/JP2008505074A/ja not_active Withdrawn
- 2005-05-13 MX MXPA06015027A patent/MXPA06015027A/es active IP Right Grant
- 2005-05-13 WO PCT/US2005/016833 patent/WO2006007095A2/en active Application Filing
- 2005-05-24 AR ARP050102149A patent/AR049117A1/es unknown
- 2005-10-28 US US11/260,662 patent/US8940329B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MXPA06015027A (es) | 2007-02-08 |
CA2570524A1 (en) | 2006-01-19 |
CA2570524C (en) | 2013-01-15 |
AR049117A1 (es) | 2006-06-28 |
JP2008505074A (ja) | 2008-02-21 |
EP1765296A2 (en) | 2007-03-28 |
US20060034919A1 (en) | 2006-02-16 |
US8940329B2 (en) | 2015-01-27 |
WO2006007095A2 (en) | 2006-01-19 |
WO2006007095A3 (en) | 2006-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25C | Requirement related to requested transfer of rights |
Owner name: ALBEMARLE CORPORATION (US) Free format text: A FIM DE ATENDER A TRANSFERENCIA REQUERIDA ATRAVES DA PETICAO NO 860150304347 DE 22/12/2015, E NECESSARIO APRESENTAR A TRADUCAO JURAMENTADA DO DOCUMENTO DE CESSAO, CONFORME ART. 18 DO DEC. 13.609/43. |
|
B25A | Requested transfer of rights approved |
Owner name: SI GROUP, INC. (US) |
|
B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 12A ANUIDADE. |
|
B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE RPI 2410 DE 14/03/2017 |