BRPI0512099A - uso de ácido graxo poli-insaturado ("pufa") ou um sal ou derivado do mesmo farmacologicamente aceitável, método de tratamento tópico de condições, forma de dosagem oral, e, produto farmacêutico - Google Patents

uso de ácido graxo poli-insaturado ("pufa") ou um sal ou derivado do mesmo farmacologicamente aceitável, método de tratamento tópico de condições, forma de dosagem oral, e, produto farmacêutico

Info

Publication number
BRPI0512099A
BRPI0512099A BRPI0512099-3A BRPI0512099A BRPI0512099A BR PI0512099 A BRPI0512099 A BR PI0512099A BR PI0512099 A BRPI0512099 A BR PI0512099A BR PI0512099 A BRPI0512099 A BR PI0512099A
Authority
BR
Brazil
Prior art keywords
derivative
pharmaceutically acceptable
fatty acid
polyunsaturated fatty
pufa
Prior art date
Application number
BRPI0512099-3A
Other languages
English (en)
Inventor
Ulrich Mittmann
Jean-Pierre Sachetto
Original Assignee
Tillotts Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tillotts Pharma Ag filed Critical Tillotts Pharma Ag
Publication of BRPI0512099A publication Critical patent/BRPI0512099A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

USO DE áCIDO GRAXO POLI-INSATURADO ("PUFA") OU UM SAL OU DERIVADO DO MESMO FARMACOLOGICAMENTE ACEITáVEL, MéTODO DE TRATAMENTO TóPICO DE CONDIçõES, FORMA DE DOSAGEM ORAL, E, PRODUTO FARMACêUTICO ácido graxo poli-insaturado ("PUFA") ou um sal ou derivado do mesmo farmacologicamente aceitável (tal como EPA e/ou DHA) é usado em combinação com pelo menos um de um agente imunossupressor ou um agente antineoplásico, dito agente (s) tendo pelo menos um resíduo de aminoácido, ou um sal farmacologicamente aceitável ou derivado do mesmo (tais como metotrexato ou ciclosporina) no tratamento de condições envolvendo resposta imune agudamente ou cronicamente inadequada. Condições específicas que podem ser tratadas incluem doença inflamatória crónica (por exemplo, doença de Crohn e colite ulcerativa) e doença provocada por tumor (por exemplo, câncer do intestino e câncer de próstata). Uma vantagem das modalidades preferidas da invenção é que a biodisponibilidade dos agentes imunossupressores ou antineoplásico é aumentada.
BRPI0512099-3A 2004-06-18 2005-06-15 uso de ácido graxo poli-insaturado ("pufa") ou um sal ou derivado do mesmo farmacologicamente aceitável, método de tratamento tópico de condições, forma de dosagem oral, e, produto farmacêutico BRPI0512099A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413729.5A GB0413729D0 (en) 2004-06-18 2004-06-18 A pharmaceutical composition and its use
PCT/EP2005/006412 WO2005123060A1 (en) 2004-06-18 2005-06-15 A pharmaceutical composition and its use

Publications (1)

Publication Number Publication Date
BRPI0512099A true BRPI0512099A (pt) 2008-02-06

Family

ID=32750206

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512099-3A BRPI0512099A (pt) 2004-06-18 2005-06-15 uso de ácido graxo poli-insaturado ("pufa") ou um sal ou derivado do mesmo farmacologicamente aceitável, método de tratamento tópico de condições, forma de dosagem oral, e, produto farmacêutico

Country Status (13)

Country Link
US (1) US20090018125A1 (pt)
EP (1) EP1758573A1 (pt)
JP (1) JP2008502630A (pt)
CN (1) CN101027049A (pt)
AR (1) AR049358A1 (pt)
AU (1) AU2005253719A1 (pt)
BR (1) BRPI0512099A (pt)
CA (1) CA2569697A1 (pt)
GB (1) GB0413729D0 (pt)
IL (1) IL179795A0 (pt)
MX (1) MXPA06014294A (pt)
NO (1) NO20070338L (pt)
WO (1) WO2005123060A1 (pt)

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HUE051916T2 (hu) 2009-04-29 2021-04-28 Amarin Pharmaceuticals Ie Ltd Stabil gyógyászati készítmény és annak alkalmazási módszerei
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AU2013282394B2 (en) 2012-06-29 2018-04-26 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
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US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
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US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
US10172818B2 (en) 2014-06-16 2019-01-08 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
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Also Published As

Publication number Publication date
GB0413729D0 (en) 2004-07-21
WO2005123060A1 (en) 2005-12-29
CN101027049A (zh) 2007-08-29
CA2569697A1 (en) 2005-12-29
EP1758573A1 (en) 2007-03-07
AU2005253719A1 (en) 2005-12-29
MXPA06014294A (es) 2007-05-04
IL179795A0 (en) 2007-05-15
AR049358A1 (es) 2006-07-19
NO20070338L (no) 2007-03-09
JP2008502630A (ja) 2008-01-31
US20090018125A1 (en) 2009-01-15

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