BRPI0510752A - derivados desalquilados de pirrol[2,1-b]benzotiazepinas com atividade antipsicótica atìpica - Google Patents

derivados desalquilados de pirrol[2,1-b]benzotiazepinas com atividade antipsicótica atìpica

Info

Publication number
BRPI0510752A
BRPI0510752A BRPI0510752-0A BRPI0510752A BRPI0510752A BR PI0510752 A BRPI0510752 A BR PI0510752A BR PI0510752 A BRPI0510752 A BR PI0510752A BR PI0510752 A BRPI0510752 A BR PI0510752A
Authority
BR
Brazil
Prior art keywords
derivatives
benzothiazepines
atypically
dealkylated
pyrrol
Prior art date
Application number
BRPI0510752-0A
Other languages
English (en)
Inventor
Patrizia Minetti
Maria Assunta Di Cesare
Orlando Ghirardi
Maria Ornella Tinti
Paolo Carminati
Original Assignee
Sigma Tau Ind Famaceutiche Riu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Famaceutiche Riu filed Critical Sigma Tau Ind Famaceutiche Riu
Publication of BRPI0510752A publication Critical patent/BRPI0510752A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

DERIVADOS DESALQUILADOS DE PIRROL¢2,1-b!BENZOTIAZEPINAS COM ATIVIDADE ANTIPSICÈTICA ATìPICA. A presente invenção refere-se a derivados de pirrol¢2,l-b!benzotiazepinas com a fórmula (I), em que A é CH-CH~2~ ou C=CH; R é hidrogênio, halogênio, C~ 1~ -C~ 4~ alcóxi, C~ 1~ -C~ 4~ alquiltio, C~ 1~ -C~4~ alquila, C~ 5~ - C~ 6~ cicloalquila; R~ 1~ é 1-piperazinila, 1-homopiperazinila e 1-piperidinila; R~ 2~ é hidrogênio, C~ 1~ - C~ 4~ alcóxi, C~ 1~ - C~ 4~ alquiltio, C~ 1~ - C~ 4~ alquila, CHO, CH=NOH, CH~ 2~OH. Os compostos de fórmula (I) são dotados de atividade antipsicótica atípica característica e são, conseqüêntemente, utilizáveis como fármacos, em particular para o tratamento e prevenção de esquizofrenia, estados paranóicos, estados maníaco-depressivos, distúrbios da esfera afetiva, regressão social, regressão da personalidade e alucinações. Os ditos compostos também apresentam propriedades farmacocinéticas vantajosas.
BRPI0510752-0A 2004-05-07 2005-04-28 derivados desalquilados de pirrol[2,1-b]benzotiazepinas com atividade antipsicótica atìpica BRPI0510752A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000222A ITRM20040222A1 (it) 2004-05-07 2004-05-07 Derivati dealchilati di pirrolo[2,1-b]benzotiazepine ad attivita' antipsicotica atipica.
PCT/IT2005/000246 WO2005108403A2 (en) 2004-05-07 2005-04-28 Dealkylated derivatives of pyrrolo[2,1-b]benzothiazepines with atypical antipsychotic activity

Publications (1)

Publication Number Publication Date
BRPI0510752A true BRPI0510752A (pt) 2007-11-20

Family

ID=35241343

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510752-0A BRPI0510752A (pt) 2004-05-07 2005-04-28 derivados desalquilados de pirrol[2,1-b]benzotiazepinas com atividade antipsicótica atìpica

Country Status (24)

Country Link
US (1) US7713956B2 (pt)
EP (1) EP1745054B1 (pt)
JP (1) JP2007536379A (pt)
KR (1) KR20070009735A (pt)
CN (1) CN100584846C (pt)
AR (1) AR049088A1 (pt)
AT (1) ATE414708T1 (pt)
AU (1) AU2005240868B2 (pt)
BR (1) BRPI0510752A (pt)
CA (1) CA2562864A1 (pt)
CY (1) CY1108800T1 (pt)
DE (1) DE602005011121D1 (pt)
DK (1) DK1745054T3 (pt)
ES (1) ES2318489T3 (pt)
HK (1) HK1101169A1 (pt)
HR (1) HRP20080682T3 (pt)
IT (1) ITRM20040222A1 (pt)
MX (1) MXPA06012888A (pt)
PL (1) PL1745054T3 (pt)
PT (1) PT1745054E (pt)
RS (1) RS50970B (pt)
SI (1) SI1745054T1 (pt)
TW (1) TW200603811A (pt)
WO (1) WO2005108403A2 (pt)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1301965B1 (it) 1998-07-28 2000-07-20 Sigma Tau Ind Farmaceuti Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica.
IT1317884B1 (it) * 2000-08-01 2003-07-15 Sigma Tau Ind Farmaceuti Pirrolo (2,1-b)(1,3)benzotiazepine e loro uso per la preparazione dimedicamenti ad attivita' antipsicotica classica.

Also Published As

Publication number Publication date
WO2005108403A3 (en) 2005-12-29
TW200603811A (en) 2006-02-01
CN1950381A (zh) 2007-04-18
AR049088A1 (es) 2006-06-28
PL1745054T3 (pl) 2009-05-29
ITRM20040222A1 (it) 2004-08-07
EP1745054B1 (en) 2008-11-19
DE602005011121D1 (de) 2009-01-02
KR20070009735A (ko) 2007-01-18
CY1108800T1 (el) 2012-05-23
AU2005240868B2 (en) 2010-10-21
WO2005108403A2 (en) 2005-11-17
US20070270402A1 (en) 2007-11-22
HK1101169A1 (en) 2007-10-12
HRP20080682T3 (en) 2009-02-28
AU2005240868A1 (en) 2005-11-17
PT1745054E (pt) 2009-02-09
JP2007536379A (ja) 2007-12-13
RS50970B (sr) 2010-10-31
CN100584846C (zh) 2010-01-27
SI1745054T1 (sl) 2009-02-28
CA2562864A1 (en) 2005-11-17
DK1745054T3 (da) 2009-02-09
EP1745054A2 (en) 2007-01-24
ES2318489T3 (es) 2009-05-01
US7713956B2 (en) 2010-05-11
MXPA06012888A (es) 2007-02-15
ATE414708T1 (de) 2008-12-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.