BRPI0510697A - gm3 sintase como um alvo terapêutico em complicações micro-vasculares da diabete - Google Patents
gm3 sintase como um alvo terapêutico em complicações micro-vasculares da diabeteInfo
- Publication number
- BRPI0510697A BRPI0510697A BRPI0510697-4A BRPI0510697A BRPI0510697A BR PI0510697 A BRPI0510697 A BR PI0510697A BR PI0510697 A BRPI0510697 A BR PI0510697A BR PI0510697 A BRPI0510697 A BR PI0510697A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetes
- synthase
- micro
- therapeutic target
- vascular complications
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5064—Endothelial cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Abstract
GM3 SINTASE COMO UM ALVO TERAPêUTICO EM COMPLICAçõES MICROVASCULARES DA DIABETE. A presente invenção refere-se ao uso de um inibidor da expressão ou atividade do gene de GM3 síntase para o tratamento de complicações microvasculares da diabete, e a um método de triar os compostos úteis no tratamento e/ou prevenção destas complicações.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0404971A FR2869915B1 (fr) | 2004-05-07 | 2004-05-07 | Gm3 synthase, comme cible therapeutique dans les complications microvasculaires du diabete |
FR0413530 | 2004-12-17 | ||
PCT/EP2005/003647 WO2005108600A1 (en) | 2004-05-07 | 2005-04-07 | Gm3 synthase as a therapeutic target in microvascular complications of diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0510697A true BRPI0510697A (pt) | 2007-12-26 |
Family
ID=34979036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510697-4A BRPI0510697A (pt) | 2004-05-07 | 2005-04-07 | gm3 sintase como um alvo terapêutico em complicações micro-vasculares da diabete |
Country Status (12)
Country | Link |
---|---|
US (1) | US20070224200A1 (pt) |
EP (1) | EP1743033B1 (pt) |
JP (1) | JP4921357B2 (pt) |
KR (1) | KR20070007908A (pt) |
AT (1) | ATE529531T1 (pt) |
AU (1) | AU2005240714B2 (pt) |
BR (1) | BRPI0510697A (pt) |
CA (1) | CA2565676C (pt) |
ES (1) | ES2375626T3 (pt) |
MX (1) | MXPA06012690A (pt) |
RU (1) | RU2006143156A (pt) |
WO (1) | WO2005108600A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070161586A1 (en) * | 2004-01-16 | 2007-07-12 | Takeda Pharmaceutical Company Limited | Drug for preventing and treating atherosclerosis |
US8003617B2 (en) | 2004-11-10 | 2011-08-23 | Genzyme Corporation | Methods of treating diabetes mellitus |
KR100734928B1 (ko) | 2006-02-16 | 2007-07-03 | 한국생명공학연구원 | 갱글리오사이드 GM3 합성효소를 저해하는 si핵산 및 그서열 |
SI2032134T1 (sl) | 2006-05-09 | 2015-10-30 | Genzyme Corporation | Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipida |
US8465930B2 (en) | 2006-05-30 | 2013-06-18 | Japan Science And Technology Agency | Method for detection of disease having insulin-resistant conditions |
EP2594564B1 (en) | 2007-05-31 | 2016-09-28 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
MX337396B (es) | 2007-10-05 | 2016-03-02 | Genzyme Corp | Metodo para el tratamiento de enfermedades del riñon poliquisticas con derivados de ceramica. |
US8389517B2 (en) | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
CN107935983A (zh) | 2008-10-03 | 2018-04-20 | 简詹姆公司 | 2‑酰胺基丙醇型葡糖神经酰胺合酶抑制剂 |
CA2741664C (en) * | 2008-10-31 | 2014-12-23 | Japan Science And Technology Agency | Method for selective control of helper t cell function |
US20100248365A1 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | Ganglioside biosynthesis modulators |
ES2581523T3 (es) | 2009-09-01 | 2016-09-06 | Lz Therapeutics, Inc. | Producción en cultivo celular (no bovino, no porcino) de GM1 |
JP5077901B2 (ja) * | 2009-11-27 | 2012-11-21 | 独立行政法人科学技術振興機構 | 高脂血症治療剤のスクリーニング方法 |
WO2011133918A1 (en) * | 2010-04-23 | 2011-10-27 | Isis Pharmaceuticals, Inc. | Modulation of gm3 synthase (gm3s) expression |
WO2011146804A2 (en) * | 2010-05-20 | 2011-11-24 | Lazarus Therapeutics, Inc. | Gm3 ganglioside replacement therapy |
US20130040953A1 (en) * | 2011-08-10 | 2013-02-14 | Amy S. Paller | Promotion of wound healing |
US9556467B2 (en) | 2012-01-20 | 2017-01-31 | Garnet Bio Therapeutics, Inc. | Methods of ganglioside production |
EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
WO2019082912A1 (ja) * | 2017-10-27 | 2019-05-02 | 学校法人北里研究所 | 慢性腎臓病の予防又は治療剤 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5000000A (en) * | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
US6555371B1 (en) * | 1997-07-09 | 2003-04-29 | Seikagaku Kogyo Kabushiki Kaisha | Sialyltransferase and DNA encoding the same |
US6280989B1 (en) * | 1999-06-17 | 2001-08-28 | Dmitri Kapitonov | Sialyltransferases |
EP3604537B1 (en) * | 2003-06-13 | 2021-12-08 | Alnylam Europe AG | Double-stranded ribonucleic acid with increased effectiveness in an organism |
-
2005
- 2005-04-07 US US11/579,725 patent/US20070224200A1/en not_active Abandoned
- 2005-04-07 JP JP2007511904A patent/JP4921357B2/ja not_active Expired - Fee Related
- 2005-04-07 KR KR1020067023221A patent/KR20070007908A/ko not_active Application Discontinuation
- 2005-04-07 AT AT05716551T patent/ATE529531T1/de not_active IP Right Cessation
- 2005-04-07 CA CA2565676A patent/CA2565676C/en not_active Expired - Fee Related
- 2005-04-07 AU AU2005240714A patent/AU2005240714B2/en not_active Ceased
- 2005-04-07 MX MXPA06012690A patent/MXPA06012690A/es not_active Application Discontinuation
- 2005-04-07 RU RU2006143156/13A patent/RU2006143156A/ru unknown
- 2005-04-07 ES ES05716551T patent/ES2375626T3/es active Active
- 2005-04-07 EP EP05716551A patent/EP1743033B1/en active Active
- 2005-04-07 WO PCT/EP2005/003647 patent/WO2005108600A1/en active Application Filing
- 2005-04-07 BR BRPI0510697-4A patent/BRPI0510697A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP4921357B2 (ja) | 2012-04-25 |
WO2005108600A1 (en) | 2005-11-17 |
US20070224200A1 (en) | 2007-09-27 |
KR20070007908A (ko) | 2007-01-16 |
RU2006143156A (ru) | 2008-06-20 |
ATE529531T1 (de) | 2011-11-15 |
AU2005240714A1 (en) | 2005-11-17 |
AU2005240714B2 (en) | 2011-07-07 |
MXPA06012690A (es) | 2007-01-16 |
CA2565676C (en) | 2013-08-13 |
EP1743033A1 (en) | 2007-01-17 |
CA2565676A1 (en) | 2005-11-17 |
JP2007536292A (ja) | 2007-12-13 |
ES2375626T3 (es) | 2012-03-02 |
EP1743033B1 (en) | 2011-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |