BRPI0507921A - beta-lactonas substituìdas por carbamato de alquila como inibidores de lipase - Google Patents

beta-lactonas substituìdas por carbamato de alquila como inibidores de lipase

Info

Publication number
BRPI0507921A
BRPI0507921A BRPI0507921-7A BRPI0507921A BRPI0507921A BR PI0507921 A BRPI0507921 A BR PI0507921A BR PI0507921 A BRPI0507921 A BR PI0507921A BR PI0507921 A BRPI0507921 A BR PI0507921A
Authority
BR
Brazil
Prior art keywords
lactones
lipase inhibitors
substituted beta
carbamate substituted
compounds
Prior art date
Application number
BRPI0507921-7A
Other languages
English (en)
Inventor
Harald Waldeck
Jochen Antel
Sabine Eyting
Michael Wurl
Peter-Colin Gregory
Maike Wolf
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of BRPI0507921A publication Critical patent/BRPI0507921A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

BETA-LACTONAS SUBSTITUìDAS POR CARBAMATO DE ALQUILA COMO INIBIDORES DE LIPASE. A presente invenção refere-se a <225>-lactonas substituídas (oxetanonas) da fórmula geral I, em que R¬1¬, R¬2¬ e n possuem os significados indicados na descrição bem como medicamentos contendo estes compostos, com atividade inibidora da lipase pancreática. Além disso indicados um processo para a preparação dos compostos da fórmula I e os produtos intermediários deste processo.
BRPI0507921-7A 2004-02-23 2005-02-18 beta-lactonas substituìdas por carbamato de alquila como inibidores de lipase BRPI0507921A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004009076A DE102004009076A1 (de) 2004-02-23 2004-02-23 Alkylcarbamat-substituierte β-Lactone, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
PCT/EP2005/050719 WO2005080366A1 (de) 2004-02-23 2005-02-18 Alkylcarbamat-substituierte beta-lactone als lipase-inhibitoren

Publications (1)

Publication Number Publication Date
BRPI0507921A true BRPI0507921A (pt) 2007-07-17

Family

ID=34877095

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507921-7A BRPI0507921A (pt) 2004-02-23 2005-02-18 beta-lactonas substituìdas por carbamato de alquila como inibidores de lipase

Country Status (12)

Country Link
EP (1) EP1751126B1 (pt)
JP (1) JP2007523131A (pt)
CN (1) CN1910168B (pt)
AR (1) AR047965A1 (pt)
AT (1) ATE479672T1 (pt)
AU (1) AU2005214088B2 (pt)
BR (1) BRPI0507921A (pt)
CA (1) CA2560446A1 (pt)
DE (2) DE102004009076A1 (pt)
HK (1) HK1099754A1 (pt)
TW (1) TW200530208A (pt)
WO (1) WO2005080366A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11339126B2 (en) * 2017-07-12 2022-05-24 Mayo Foundation For Medical Education And Research Compounds for the reducing lipotoxic damage

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1270837A (en) * 1984-12-21 1990-06-26 Hoffmann-La Roche Limited Oxetanones
US4806564A (en) * 1987-05-26 1989-02-21 Merck & Co., Inc. Antihypercholesterolemic beta-lactones
US4873260A (en) * 1988-06-27 1989-10-10 Merck & Co., Inc. Treatment of diabetic ketoacidosis
IL97148A (en) * 1990-02-26 1996-11-14 Hoffmann La Roche Oxtanones, the process for their preparation and the pharmaceutical preparations containing them
US6342519B2 (en) * 1999-10-29 2002-01-29 2 Pro Chemical Oxetanone derivatives
AU1238101A (en) * 1999-10-29 2001-05-14 John Jason Gentry Mullins Oxetanone derivatives

Also Published As

Publication number Publication date
TW200530208A (en) 2005-09-16
WO2005080366A8 (de) 2006-01-19
DE502005010179D1 (en) 2010-10-14
EP1751126B1 (de) 2010-09-01
CN1910168A (zh) 2007-02-07
JP2007523131A (ja) 2007-08-16
AU2005214088A1 (en) 2005-09-01
EP1751126A1 (de) 2007-02-14
CA2560446A1 (en) 2005-09-01
AR047965A1 (es) 2006-03-15
ATE479672T1 (de) 2010-09-15
HK1099754A1 (en) 2007-08-24
AU2005214088B2 (en) 2010-12-09
CN1910168B (zh) 2011-03-30
WO2005080366A1 (de) 2005-09-01
DE102004009076A1 (de) 2005-10-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE, CONFORME ART. 10 DA RES. 124/06.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013.