BRPI0507451A - method and combination therapy to inhibit tumor growth and / or metastatic progression and / or development of metastases, and use of an anti-alpha4 integrin immunoglobulin - Google Patents

method and combination therapy to inhibit tumor growth and / or metastatic progression and / or development of metastases, and use of an anti-alpha4 integrin immunoglobulin

Info

Publication number
BRPI0507451A
BRPI0507451A BRPI0507451-7A BRPI0507451A BRPI0507451A BR PI0507451 A BRPI0507451 A BR PI0507451A BR PI0507451 A BRPI0507451 A BR PI0507451A BR PI0507451 A BRPI0507451 A BR PI0507451A
Authority
BR
Brazil
Prior art keywords
metastases
tumor growth
development
inhibit tumor
combination therapy
Prior art date
Application number
BRPI0507451-7A
Other languages
Portuguese (pt)
Inventor
Nancy Wehner
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of BRPI0507451A publication Critical patent/BRPI0507451A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

MéTODO E TERAPIA COMBINADA PARA INIBIR O CRESCIMENTO DE TUMOR E/OU PROGRESSãO METASTáTICA E/OU DESENVOLVIMENTO DE METáSTASES, E, USO DE UMA IMUNOGLOBULINA ANTI- ALFA4 INTEGRINA Composições, métodos e terapias combinadas para o tratamento de linfomas, leucemias, melanomas, câncer de próstata, e doença metastática são providos. Especificamente, as composições compreendendo imunoglobulinas anti-<244>4 integrina ou imunoglobulinas que se ligam a um ligando de <244>4 integrina (por exemplo MadCAM-1 e VCAM-1) são descritos para uso na inibição do crescimento de tumor e progressão e inibição de metástases. Uma imunoglobulina preferida para uso no tratamento de tumores e metástases é natalizumab. As composições e métodos usando estas imunoglobulinas podem ser usados sozinhos ou em combinação com outros reagentes e modalidades de tratamento de câncer.METHOD AND COMBINED THERAPY TO INHIBIT TUMOR GROWTH AND / OR METHASTATIC PROGRESS AND / OR METHODASE DEVELOPMENT, AND USE OF ANTI-ALPHA4 INTEGRINE IMMUNOGLOBULIN Combined compositions, methods and therapies for the treatment of lymphomas, leukemias, leukemias, cancer, prostate, and metastatic disease are provided. Specifically, compositions comprising anti-β4 integrin immunoglobulins or immunoglobulins that bind to a β4 integrin ligand (e.g. MadCAM-1 and VCAM-1) are described for use in inhibiting tumor growth and progression. and inhibition of metastases. A preferred immunoglobulin for use in the treatment of tumors and metastases is natalizumab. Compositions and methods using these immunoglobulins may be used alone or in combination with other cancer treatment reagents and modalities.

BRPI0507451-7A 2004-02-06 2005-02-03 method and combination therapy to inhibit tumor growth and / or metastatic progression and / or development of metastases, and use of an anti-alpha4 integrin immunoglobulin BRPI0507451A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54194604P 2004-02-06 2004-02-06
PCT/US2005/002860 WO2005076843A2 (en) 2004-02-06 2005-02-03 Methods and compositions for treating tumors and metastatic disease

Publications (1)

Publication Number Publication Date
BRPI0507451A true BRPI0507451A (en) 2007-07-10

Family

ID=34860234

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507451-7A BRPI0507451A (en) 2004-02-06 2005-02-03 method and combination therapy to inhibit tumor growth and / or metastatic progression and / or development of metastases, and use of an anti-alpha4 integrin immunoglobulin

Country Status (19)

Country Link
US (1) US20050255118A1 (en)
EP (2) EP1718310A4 (en)
JP (1) JP4996261B2 (en)
KR (1) KR20070009581A (en)
CN (1) CN1946407B (en)
AR (1) AR047534A1 (en)
AU (1) AU2005213324B2 (en)
BR (1) BRPI0507451A (en)
CA (1) CA2555365A1 (en)
EA (1) EA009873B1 (en)
IL (1) IL177201A0 (en)
MX (1) MXPA06008746A (en)
NO (1) NO20063951L (en)
NZ (1) NZ584288A (en)
PE (1) PE20060009A1 (en)
TW (1) TWI375563B (en)
UY (1) UY28741A1 (en)
WO (1) WO2005076843A2 (en)
ZA (1) ZA200606557B (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2004000224A1 (en) 2003-02-10 2005-01-21 Elan Pharm Inc STABLE PHARMACEUTICAL FORMULATION THAT INCLUDES AN IMMUNOGLOBULIN, A PHOSPHATE TAMPON, A POLYSORBATE AND SODIUM CHLORIDE, METHOD OF PREPARATION AND ITS USE.
UY28716A1 (en) 2004-01-09 2005-08-31 Pfizer ANTIBODIES AGAINST MADCAM
WO2007007152A2 (en) * 2005-07-11 2007-01-18 Pfizer Limited Anti-madcam antibodies to treat metastatic cancers and chloroma
EP2109460B1 (en) 2007-01-11 2016-05-18 Novo Nordisk A/S Anti-kir antibodies, formulations, and uses thereof
CA2708262A1 (en) * 2007-12-07 2009-06-18 Elan Pharmaceuticals, Inc. Methods and compositions for treating liquid tumors
GB0800311D0 (en) * 2008-01-09 2008-02-20 Cytosystems Ltd Apparatus and method for filtering biological material
US20110110940A1 (en) * 2008-04-15 2011-05-12 Oxigene, Inc. Methods for Enhancing the Efficacy of Vascular Disrupting Agents
US20100158893A1 (en) * 2008-12-19 2010-06-24 Baxter International Inc. Systems and methods for obtaining immunoglobulin from blood
AU2010236257A1 (en) * 2009-04-17 2011-11-03 Biogen Idec Ma Inc. Compositions and methods to treat acute myelogenous leukemia
US20110158982A1 (en) * 2009-10-05 2011-06-30 The Regents Of The University Of Michigan COMPOSITIONS AND METHODS FOR INHIBITING MAdCAM
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
SI3326645T1 (en) 2010-10-25 2020-09-30 Biogen Ma Inc. Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels
RU2665952C2 (en) 2011-07-22 2018-09-05 Пасилекс Фармасьютикалз Инк. Synthetic lethality and the treatment of cancer
US20160074337A1 (en) * 2011-08-17 2016-03-17 Dennis Brown Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dibromodulcitol
WO2014018913A2 (en) * 2012-07-27 2014-01-30 University Of Connecticut Santacruzamate a compositions and analogs and methods of use
US9657105B2 (en) * 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
RU2527154C1 (en) * 2013-03-27 2014-08-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Method for increasing cisplatin bioavailability in experimentally induced sarcoma 45
RU2702428C2 (en) * 2013-04-29 2019-10-08 Огд2 Фарма Use of o-acetylated gd2 ganglioside as target as novel therapeutic and diagnostic approach in malignant growths containing tumour stem cells
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
KR102320190B1 (en) 2014-01-24 2021-11-03 에이아이 테라퓨틱스, 인코포레이티드 Apilimod Compositions and Methods for Using Same
EP3122866B1 (en) 2014-03-25 2019-11-20 Terumo BCT, Inc. Passive replacement of media
CN106715676A (en) 2014-09-26 2017-05-24 泰尔茂比司特公司 Scheduled feed
BR112017009000A2 (en) 2014-11-07 2017-12-19 Lam Therapeutics Inc apilimod for use in the treatment of melanoma
ES2741399T3 (en) 2014-11-07 2020-02-10 Ai Therapeutics Inc Apilimod for use in the treatment of renal cancer
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
PL3325662T3 (en) 2015-07-17 2024-02-26 Pacylex Pharmaceuticals Inc. Epigenetic silencing of nmt2
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN117247899A (en) 2017-03-31 2023-12-19 泰尔茂比司特公司 cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
RU2650587C1 (en) * 2017-04-26 2018-04-16 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Method of the melanoma b16 malignant growth in mice modification with chronic pain
CR20200076A (en) 2017-07-14 2020-06-10 Pfizer Antibodies to madcam
AU2019337603A1 (en) * 2018-09-13 2021-05-13 Nkarta, Inc. Natural killer cell compositions and immunotherapy methods for treating tumors
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
RU2762730C1 (en) * 2021-03-30 2021-12-22 Елена Рудольфовна Милаева Means for inhibiting metastasis in the lungs
RU2765955C1 (en) * 2021-03-30 2022-02-07 Елена Рудольфовна Милаева Pulmonary metastasis inhibitor

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
US6033665A (en) 1989-09-27 2000-03-07 Elan Pharmaceuticals, Inc. Compositions and methods for modulating leukocyte adhesion to brain endothelial cells
CA2072249C (en) 1991-06-28 2003-06-17 Saiko Hosokawa Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
NZ261259A (en) * 1993-01-12 1996-12-20 Biogen Inc Humanised recombinant anti-vla4 antibody and diagnostic compositions and medicaments
US5840299A (en) 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
WO1996010585A1 (en) 1994-09-30 1996-04-11 Inex Pharmaceuticals Corp. Glycosylated protein-liposome conjugates and methods for their preparation
US6551593B1 (en) 1995-02-10 2003-04-22 Millennium Pharmaceuticals, Inc. Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam
US6235309B1 (en) * 1997-02-28 2001-05-22 The Regents Of The University Of California Inhibition of cell-cell binding by lipid assemblies
MY153569A (en) * 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
HU229038B1 (en) * 1998-09-14 2013-07-29 Regents Board Of Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists
DE60043308D1 (en) 1999-12-16 2009-12-24 Biogen Idec Inc METHOD FOR TREATING THE INJURY OF THE CENTRAL NERVOUS SYSTEM BY ISCHEMIA OR BY HEMORRHAGIA WITH ANTAGONISTS OF ALPHA4 INTEGRIN
US20020076408A1 (en) * 2000-12-08 2002-06-20 Buchsbaum Donald J. Combination radiation therapy and chemotherapy in conjunction with administration of growth factor receptor antibody
JP2005506957A (en) * 2001-06-11 2005-03-10 トランジション・セラピューティックス・インコーポレーテッド Combined treatment with vitamin B12 and interferon for the treatment of viral, proliferative and inflammatory diseases
US7824680B2 (en) * 2001-08-06 2010-11-02 The Regents Of The University Of California Methods for inhibiting angiogenesis
US20040009169A1 (en) * 2002-02-25 2004-01-15 Julie Taylor Administration of agents for the treatment of inflammation
WO2005056606A2 (en) * 2003-12-03 2005-06-23 Xencor, Inc Optimized antibodies that target the epidermal growth factor receptor
EP1682179A4 (en) * 2003-11-05 2008-09-03 Palingen Inc Enhanced b cell cytotoxicity of cdim binding antibody

Also Published As

Publication number Publication date
TW200536556A (en) 2005-11-16
AR047534A1 (en) 2006-01-25
WO2005076843A2 (en) 2005-08-25
EA200601433A1 (en) 2007-02-27
EP1718310A2 (en) 2006-11-08
IL177201A0 (en) 2006-12-10
UY28741A1 (en) 2005-08-31
NZ584288A (en) 2011-10-28
MXPA06008746A (en) 2007-01-23
EP1718310A4 (en) 2009-05-06
WO2005076843A3 (en) 2006-01-26
JP4996261B2 (en) 2012-08-08
EA009873B1 (en) 2008-04-28
EP2394652A3 (en) 2012-10-24
TWI375563B (en) 2012-11-01
CN1946407A (en) 2007-04-11
NO20063951L (en) 2006-11-02
JP2007520557A (en) 2007-07-26
CN1946407B (en) 2011-10-05
ZA200606557B (en) 2008-02-27
AU2005213324A1 (en) 2005-08-25
CA2555365A1 (en) 2005-08-25
EP2394652A2 (en) 2011-12-14
PE20060009A1 (en) 2006-02-11
AU2005213324B2 (en) 2011-06-09
KR20070009581A (en) 2007-01-18
US20050255118A1 (en) 2005-11-17

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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