BRPI0507406A - método de tratamento de acne vulgaris, e, uso de um fotossensibilizante de porfirina verde e solubilizador - Google Patents
método de tratamento de acne vulgaris, e, uso de um fotossensibilizante de porfirina verde e solubilizadorInfo
- Publication number
- BRPI0507406A BRPI0507406A BRPI0507406-1A BRPI0507406A BRPI0507406A BR PI0507406 A BRPI0507406 A BR PI0507406A BR PI0507406 A BRPI0507406 A BR PI0507406A BR PI0507406 A BRPI0507406 A BR PI0507406A
- Authority
- BR
- Brazil
- Prior art keywords
- acne vulgaris
- solubilizer
- green porphyrin
- treating acne
- photosensitizer
- Prior art date
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title abstract 4
- 206010000496 acne Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000003504 photosensitizing agent Substances 0.000 title abstract 4
- 150000004032 porphyrins Chemical class 0.000 title abstract 3
- 239000002904 solvent Substances 0.000 title abstract 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 abstract 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- -1 lemuteporphine Chemical class 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 238000002428 photodynamic therapy Methods 0.000 abstract 1
- 230000002165 photosensitisation Effects 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
MéTODO DE TRATAMENTO DE ACNE VULGARIS, E, USO DE UM FOTOSSENSIBILIZANTE DE PORFIRINA VERDE E SOLUBILIZADOR O presente método envolve o tratamento fotodinâmico de acne vulgaris. O método envolve a administração tópica de uma composição de fotossensibilizante compreendendo porfirinas verdes hidrofóbicas como lemuteporfina, polietileno glicol e melhoradores da penetração na pele, como álcool oleílico, e TRANSCUTOL <sym> a pele afetada com acne e subsequente exposição desta pele a energia de um comprimento de onda de ativação do fotossensibilizante.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002457214A CA2457214A1 (en) | 2004-02-06 | 2004-02-06 | Photodynamic therapy for the treatment of acne |
CA002470403A CA2470403A1 (en) | 2004-02-06 | 2004-06-09 | Photodynamic therapy for the treatment of hyperactive sebaceous gland disorders |
PCT/CA2005/000141 WO2005074987A1 (en) | 2004-02-06 | 2005-02-04 | Photodynamic therapy for the treatment of acne |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0507406A true BRPI0507406A (pt) | 2007-06-26 |
Family
ID=34839264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507406-1A BRPI0507406A (pt) | 2004-02-06 | 2005-02-04 | método de tratamento de acne vulgaris, e, uso de um fotossensibilizante de porfirina verde e solubilizador |
Country Status (7)
Country | Link |
---|---|
US (2) | US20100056982A1 (pt) |
EP (3) | EP1720576A4 (pt) |
JP (1) | JP2007522137A (pt) |
AU (1) | AU2005209955A1 (pt) |
BR (1) | BRPI0507406A (pt) |
CA (3) | CA2457214A1 (pt) |
WO (1) | WO2005074987A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0511897A (pt) * | 2004-06-09 | 2008-01-15 | Quadra Logic Tech Inc | método para tratar distúrbios de glándula sebácea hiperativa, e, uso de uma composição fotossensibilizadora hidrofóbica e/ou lipofìlica |
AU2011253786B2 (en) * | 2004-06-09 | 2014-10-09 | Valeant Pharmaceuticals International, Inc. | Photodynamic therapy for the treatment of hyperactive sebaceous gland disorders using topically applied hydrophobic green porphyrins |
US20090131499A1 (en) * | 2007-11-15 | 2009-05-21 | Ceramoptec Industries Inc. | Photodynamic therapy for skin related problems |
WO2009093144A2 (en) * | 2008-01-25 | 2009-07-30 | Qlt, Inc.Lau | Photodynamic therapy of sebaceous gland disorders |
FR2927800A1 (fr) * | 2008-02-25 | 2009-08-28 | Oreal | Association d'un rayonnement lumineux et d'un compose bioconvertible par la lipase pour ameliorer l'apparence de la peau et/ou du cheveu. |
US20120164210A1 (en) | 2008-12-17 | 2012-06-28 | The University Of Tokyo | Photodynamic therapeutic agent having cell-specific active accumulation properties |
US8815931B2 (en) * | 2009-04-28 | 2014-08-26 | Biolitec Pharma Marketing Ltd | Oral formulations for tetrapyrrole derivatives |
ES2573085T3 (es) * | 2009-06-11 | 2016-06-06 | Photocure Asa | Composiciones y productos farmacéuticos semisólidos |
WO2011005660A1 (en) | 2009-07-08 | 2011-01-13 | Valocor Therapeutics, Inc. | Tofa analogs useful in treating dermatological disorders or conditions |
US20130178787A1 (en) * | 2010-07-09 | 2013-07-11 | Photocure Asa | Dry Compositions and Devices Containing Such Dry Compostions for Use in Photodynamic Therapy or Photodynamic Diagnosis |
EP2663285A2 (en) | 2011-01-13 | 2013-11-20 | Qlt Inc. | Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof |
US9687669B2 (en) | 2011-11-09 | 2017-06-27 | John Stephan | Wearable light therapy apparatus |
US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
US20150209428A1 (en) * | 2012-07-11 | 2015-07-30 | Dermira, Inc. | Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof |
WO2014131115A1 (en) * | 2013-03-01 | 2014-09-04 | Klox Technologies Inc. | Phototherapeutic device, method and use |
KR20150004092A (ko) * | 2013-07-02 | 2015-01-12 | 제너럴바이오(주) | 칼란코에 추출물이 포함된 항산화 액상 조성물 |
EP3016686A4 (en) | 2013-07-03 | 2017-01-25 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
KR101623553B1 (ko) * | 2013-07-23 | 2016-05-23 | 동성제약주식회사 | 여드름 치료, 예방 또는 개선에 유효한 클로린 e6 |
CN105899201A (zh) * | 2013-12-20 | 2016-08-24 | 盖尔德马研究及发展公司 | 光损伤的皮肤的脉冲光动力治疗 |
RU2016142722A (ru) | 2014-04-01 | 2018-05-04 | Клокс Текнолоджиз Инк. | Композиции наполнителей для тканей и способы их применения |
US9950147B2 (en) * | 2014-09-12 | 2018-04-24 | Je Matadi, Inc. | Apparatus and method for administering a skin care composition |
US20180117355A1 (en) * | 2015-05-12 | 2018-05-03 | Klox Technologies Inc. | Devices and methods for phototherapy |
US20190083809A1 (en) | 2016-07-27 | 2019-03-21 | Z2020, Llc | Componentry and devices for light therapy delivery and methods related thereto |
CN112451862B (zh) * | 2020-11-24 | 2023-03-28 | 深圳罗兹曼国际转化医学研究院 | 光动力治疗系统及其控制方法 |
WO2023059180A1 (en) * | 2021-10-06 | 2023-04-13 | Tunku Abdul Rahman University Of Management And Technology (Tar Umt) | Treating skin diseases using a photodynamic therapy (pdt) and a topical agent photosensitizer formulation |
Family Cites Families (30)
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US4861764A (en) | 1986-11-17 | 1989-08-29 | Macro Chem. Corp. | Percutaneous absorption enhancers, compositions containing same and method of use |
US5283255A (en) | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
US5095030A (en) | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US5171749A (en) | 1987-01-20 | 1992-12-15 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US4883790A (en) | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US4920143A (en) | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
GB8805849D0 (en) | 1988-03-11 | 1988-04-13 | Efamol Holdings | Porphyrins & cancer treatment |
US5955490A (en) * | 1989-07-28 | 1999-09-21 | Queen's University At Kingston | Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins |
US6492420B2 (en) * | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
IL116126A0 (en) | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
HU221754B1 (hu) * | 1997-05-07 | 2002-12-28 | Qlt Inc | Fotoaktív szerekként alkalmazható monohidrobenzoporfirin származékok etilénglikol észterei |
US5880145A (en) | 1997-05-07 | 1999-03-09 | The University Of British Columbia | Class of benzoporphyrin derivative photoactive compounds |
IL132494A0 (en) * | 1997-05-07 | 2001-03-19 | Univ British Columbia | A new class of benzoporphyrin derivative photoactive compounds |
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EP1100366B1 (en) | 1998-07-09 | 2009-04-15 | Curelight Medical Ltd | Apparatus and method for efficient high energy photodynamic therapy of acne vulgaris and seborrhea |
EP1100490B1 (en) * | 1998-07-28 | 2006-12-13 | Susan Bershad | Short contact treatment of acne and photoaging with topical retinoids |
US6887260B1 (en) * | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6183773B1 (en) * | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
IL133253A0 (en) | 1999-12-01 | 2001-04-30 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
GB0005855D0 (en) | 2000-03-10 | 2000-05-03 | Scotia Holdings Plc | Compounds for pdt |
GB2370992B (en) | 2000-03-23 | 2002-11-20 | Photo Therapeutics Ltd | Therapeutic light source and method |
GB2361430A (en) * | 2000-04-17 | 2001-10-24 | Photo Therapeutics Ltd | Therapeutic discharge lamps |
GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
EP2269645A3 (en) | 2000-08-16 | 2011-01-12 | The General Hospital Corporation doing business as Massachusetts General Hospital | Topical aminolevulinic acid-photodynamic therapy for acne vulgaris |
GB2368020A (en) * | 2000-10-18 | 2002-04-24 | Icn Photonics Ltd | Treatment of acne vulgaris skin condition by irradiation with light of specific wavelengths to target specific chromophores & stimulate collagen production |
US6984395B2 (en) * | 2001-04-11 | 2006-01-10 | Qlt, Inc. | Drug delivery system for hydrophobic drugs |
US7018396B2 (en) * | 2001-08-07 | 2006-03-28 | New England Medical Center Hospitals, Inc. | Method of treating acne |
JP2005514346A (ja) * | 2001-11-09 | 2005-05-19 | キュー エル ティー インク. | 光感作剤及び皮膚浸透エンハンサーを含有する組成物並びに光力学療法におけるそれらの使用 |
US20040073277A1 (en) | 2002-04-05 | 2004-04-15 | Geronemus Roy G. | High fluence rate activation of photosensitizers for dermatological applications |
US20040228822A1 (en) * | 2003-05-16 | 2004-11-18 | Khaiat Alain V. | Topical treatment of skin conditions |
-
2004
- 2004-02-06 CA CA002457214A patent/CA2457214A1/en not_active Abandoned
- 2004-06-09 CA CA002470403A patent/CA2470403A1/en not_active Abandoned
-
2005
- 2005-02-04 JP JP2006551694A patent/JP2007522137A/ja active Pending
- 2005-02-04 CA CA2554591A patent/CA2554591C/en not_active Expired - Fee Related
- 2005-02-04 AU AU2005209955A patent/AU2005209955A1/en not_active Abandoned
- 2005-02-04 US US10/588,571 patent/US20100056982A1/en not_active Abandoned
- 2005-02-04 WO PCT/CA2005/000141 patent/WO2005074987A1/en active Application Filing
- 2005-02-04 EP EP05714422A patent/EP1720576A4/en not_active Withdrawn
- 2005-02-04 BR BRPI0507406-1A patent/BRPI0507406A/pt not_active IP Right Cessation
- 2005-02-04 EP EP13165960.9A patent/EP2659909A3/en not_active Withdrawn
- 2005-02-04 EP EP12170201A patent/EP2494989A1/en not_active Withdrawn
- 2005-02-08 US US10/588,419 patent/US20080096857A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2457214A1 (en) | 2005-08-06 |
EP1720576A1 (en) | 2006-11-15 |
EP2659909A2 (en) | 2013-11-06 |
EP1720576A4 (en) | 2010-12-22 |
CA2554591A1 (en) | 2005-08-18 |
EP2494989A1 (en) | 2012-09-05 |
CA2470403A1 (en) | 2005-08-06 |
JP2007522137A (ja) | 2007-08-09 |
US20100056982A1 (en) | 2010-03-04 |
EP2659909A3 (en) | 2014-08-13 |
AU2005209955A1 (en) | 2005-08-18 |
WO2005074987A1 (en) | 2005-08-18 |
CA2554591C (en) | 2014-12-02 |
US20080096857A1 (en) | 2008-04-24 |
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |