BRPI0418845A - uso de compostos de kauranes na fabricação de medicamentos - Google Patents

uso de compostos de kauranes na fabricação de medicamentos

Info

Publication number
BRPI0418845A
BRPI0418845A BRPI0418845-4A BRPI0418845A BRPI0418845A BR PI0418845 A BRPI0418845 A BR PI0418845A BR PI0418845 A BRPI0418845 A BR PI0418845A BR PI0418845 A BRPI0418845 A BR PI0418845A
Authority
BR
Brazil
Prior art keywords
hydroxyl
compounds
methyl
ester
manufacture
Prior art date
Application number
BRPI0418845-4A
Other languages
English (en)
Inventor
We Tan
Original Assignee
We Tan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by We Tan filed Critical We Tan
Publication of BRPI0418845A publication Critical patent/BRPI0418845A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

USO DE COMPOSTOS DE KAURANES NA FABRICAçãO DE MEDICAMENTOS. A invenção refere-se ao uso farmacêutico de compostos de kaurene da fórmula (I) no tratamento e prevenção de doença coronária, acidente vascular cerebral, arritmia e isquemia cerebral etc. Os referidos compostos também têm efeitos protetores significantes contra infarto isquêmico cerebral, em que R¬ 1¬: hidrogênio, hidroxila ou alcóxi, R¬ 2¬: carboxila, carboxilato, haletos de acila, aldeído, metilidroxila, e grupo de éster, acilamida, acila ou éter hidrolisável por carboxila, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬, R¬ 8¬: independentemente, oxigênio, hidroxila, meti-lidroxila, e éster ou grupo de alquiloximetila hidrolisável por metilldroxila, R¬ 7¬: metila, hidroxila e éster ou alquiloximetila hidrolisável por metilidroxila, R¬ 9¬: metileno ou oxigênio.
BRPI0418845-4A 2004-05-19 2004-05-19 uso de compostos de kauranes na fabricação de medicamentos BRPI0418845A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2004/000508 WO2005110383A1 (en) 2004-05-19 2004-05-19 The use of kauranes compounds in the manufacture of medicament

Publications (1)

Publication Number Publication Date
BRPI0418845A true BRPI0418845A (pt) 2007-11-13

Family

ID=35393975

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418845-4A BRPI0418845A (pt) 2004-05-19 2004-05-19 uso de compostos de kauranes na fabricação de medicamentos

Country Status (9)

Country Link
US (1) US9125877B2 (pt)
EP (1) EP1757282B1 (pt)
JP (1) JP2007538016A (pt)
CN (1) CN100508962C (pt)
AU (1) AU2004319792A1 (pt)
BR (1) BRPI0418845A (pt)
CA (1) CA2606472A1 (pt)
MX (1) MXPA06013503A (pt)
WO (1) WO2005110383A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101633609B (zh) * 2009-08-12 2013-11-06 曹庸 一种从山莓叶中分离出的新化合物、制备方法及用途
CN103755585A (zh) * 2013-11-18 2014-04-30 福建医科大学 对映贝壳杉烯类二萜化合物的衍生物及其制备方法和应用
EP3212199B1 (en) * 2014-10-31 2022-12-28 Fresenius Medical Care Deutschland GmbH Pharmaceutical compositions containing steviosides
WO2016077581A1 (en) * 2014-11-12 2016-05-19 University Of Florida Research Foundation, Inc. Isosteviol triazoles and uses thereof
CN112791079A (zh) * 2015-09-10 2021-05-14 东莞市凯法生物医药有限公司 贝壳杉烷类化合物在制备治疗勃起功能障碍的药物应用
CN109925302A (zh) * 2019-02-18 2019-06-25 东莞市凯法生物医药有限公司 一种使用贝壳杉烷类化合物保护蒽环类抗肿瘤药物心脏毒性的应用
JP2022532619A (ja) * 2019-05-13 2022-07-15 キー ファーマ バイオメディカル インク 新たなカウラン類似体、その調製および治療的使用
CN115137718A (zh) * 2020-11-15 2022-10-04 珠海沅芷健康科技有限公司 一种制备恢复心脏肥厚病中减低的CNPase活性的药物的方法
CN113845424B (zh) * 2021-10-14 2023-09-12 南京医科大学 右崁醇酯类化合物及其药物用途
CN114917237A (zh) * 2022-05-13 2022-08-19 葛鹏飞 莱苞迪甙a在制备预防和/或治疗脑缺血所致神经元损伤药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002037716A (ja) * 2000-07-24 2002-02-06 Shiseido Co Ltd カウレン類含有組成物、養毛剤及び皮膚外用剤
KR100383149B1 (ko) 2000-12-12 2003-05-12 한국생명공학연구원 디테르펜계 화합물을 염증질환, 면역질환 및 암 치료제로사용하는 신규한 용도
AU2001279593A1 (en) * 2001-02-01 2002-08-12 Soren Gregersen A substance for use in a dietary supplement or for the preparation of a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome

Also Published As

Publication number Publication date
EP1757282A1 (en) 2007-02-28
MXPA06013503A (es) 2007-06-12
US20100179097A1 (en) 2010-07-15
CN1997358A (zh) 2007-07-11
WO2005110383A1 (en) 2005-11-24
AU2004319792A1 (en) 2005-11-24
CA2606472A1 (en) 2005-11-24
EP1757282B1 (en) 2015-02-25
US9125877B2 (en) 2015-09-08
CN100508962C (zh) 2009-07-08
EP1757282A4 (en) 2010-02-10
JP2007538016A (ja) 2007-12-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]