BRPI0418038A - hidrogenação catalìtica de nitrilos para produzir derivados de capsaicinóide e compostos de amina, e métodos para a purificação e obtenção dos seus polimorfos - Google Patents

hidrogenação catalìtica de nitrilos para produzir derivados de capsaicinóide e compostos de amina, e métodos para a purificação e obtenção dos seus polimorfos

Info

Publication number
BRPI0418038A
BRPI0418038A BRPI0418038-0A BRPI0418038A BRPI0418038A BR PI0418038 A BRPI0418038 A BR PI0418038A BR PI0418038 A BRPI0418038 A BR PI0418038A BR PI0418038 A BRPI0418038 A BR PI0418038A
Authority
BR
Brazil
Prior art keywords
amine
polymorphs
purifying
obtaining
produce
Prior art date
Application number
BRPI0418038-0A
Other languages
English (en)
Inventor
Harold Meckler
Karl F Popp
Bingidimi I Mobele
Paul K Isbester
Bruce J Elder
Paul F Vogt
Benjamin J Littler
Stephen A Eastham
David P Reed
Luckner G Ulysse
Michael D Uttley
Original Assignee
Stiefel Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stiefel Laboratories filed Critical Stiefel Laboratories
Publication of BRPI0418038A publication Critical patent/BRPI0418038A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"HIDROGENAçãO CATALìTICA DE NITRILOS PARA PRODUZIR DERIVADOS DE CAPSAICINóIDE E COMPOSTOS DE AMINA, E MéTODOS PARA A PURIFICAçãO E OBTENçãO DOS SEUS POLIMORFOS". Processos para a preparação de um composto de amina por cataliticamente hidrogenar um composto de nitrila precursor. Em um aspecto particular, o presente processo de hidrogenação ocorre em um solvente orgânico dipolar na presença de um catalisador de paládio/carbono e um ácido prótico anídrico forte. Em um outro aspecto, a modalidade preferida diz respeito a um processo para a desproteção de um composto para produzir um composto de amina. Em mais um outro aspecto, a modalidade preferida diz respeito aos produtos de amina produzidos pelos presentes processos. Estes produtos de amina podem ser usados para uma variedade de propósitos.
BRPI0418038-0A 2003-12-22 2004-09-27 hidrogenação catalìtica de nitrilos para produzir derivados de capsaicinóide e compostos de amina, e métodos para a purificação e obtenção dos seus polimorfos BRPI0418038A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53098503P 2003-12-22 2003-12-22
PCT/US2004/028153 WO2005068414A1 (en) 2003-12-22 2004-09-27 Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifiying and obtaining the polymorphs thereof

Publications (1)

Publication Number Publication Date
BRPI0418038A true BRPI0418038A (pt) 2007-04-17

Family

ID=34794216

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418038-0A BRPI0418038A (pt) 2003-12-22 2004-09-27 hidrogenação catalìtica de nitrilos para produzir derivados de capsaicinóide e compostos de amina, e métodos para a purificação e obtenção dos seus polimorfos

Country Status (5)

Country Link
US (1) US20060047171A1 (pt)
EP (1) EP1697303A4 (pt)
BR (1) BRPI0418038A (pt)
CA (1) CA2551128A1 (pt)
WO (1) WO2005068414A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2285774B1 (en) 2008-06-05 2015-02-25 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Novel modulators of protein kinase signaling
EP2654741A1 (en) * 2010-12-22 2013-10-30 Galderma Research & Development Modulators and methods for the treatment of rosacea
US9770454B2 (en) 2013-07-14 2017-09-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. IGF-1R signaling pathway inhibitors useful in the treatment of neurodegenerative diseases
WO2015131019A1 (en) * 2014-02-28 2015-09-03 The Texas A&M University System Compositions and methods for inhibition of mycobacteria
EP3750530A1 (en) 2015-02-05 2020-12-16 TyrNovo Ltd. Combinations of irs/stat3 dual modulators and anti-cancer agents for treating cancer

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KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
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Also Published As

Publication number Publication date
EP1697303A1 (en) 2006-09-06
US20060047171A1 (en) 2006-03-02
EP1697303A4 (en) 2007-07-04
CA2551128A1 (en) 2005-07-28
WO2005068414A1 (en) 2005-07-28
WO2005068414A8 (en) 2005-09-15

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired