BRPI0412363A - compostos tiazol-, oxazol e imidazol - quinazolina capazes de inibirem proteìnas cinases - Google Patents
compostos tiazol-, oxazol e imidazol - quinazolina capazes de inibirem proteìnas cinasesInfo
- Publication number
- BRPI0412363A BRPI0412363A BRPI0412363-8A BRPI0412363A BRPI0412363A BR PI0412363 A BRPI0412363 A BR PI0412363A BR PI0412363 A BRPI0412363 A BR PI0412363A BR PI0412363 A BRPI0412363 A BR PI0412363A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- alkyl
- optionally substituted
- groups
- disorders
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
Abstract
"COMPOSTOS TIAZOL-, OXAZOL E IMIDAZOLQUINAZOLINA CAPAZES DE INIBIREM PROTEìNA CINASES". Composto de fórmula (I), ou um seu sal farmaceuticamente aceitável, onde: X é S, O ou NH; 'a' é uma ligação simples; ou 'a' é uma ligação dupla e um de R¬ 3¬ e R¬ 4¬, e um de R¬ 5¬ e R¬ 6¬ está ausente; R¬ 1¬ é H; ou é selecionado de um grupo alquila, um grupo cicloalquila, um grupo heteroarila, um grupo aralquila, CO-alquila, SO~ 2~-alquila, CO~ 2~R¬ 13¬ e um grupo arila, cada um dos quais opcionalmente contém um ou mais heteroátomos, e está opcionalmente substituído com um ou mais grupos selecionados de R¬ 8¬ e R¬ 9¬; R¬ 2¬ é H, R¬ 8¬, ou um grupo alquila opcionalmente substituído com um ou mais grupo R¬ 8¬; R¬ 3¬, R¬ 4¬, R¬ 5¬, e R¬ 6¬ são cada um selecionados independentemente de H, R¬ 8¬, um grupo alquila e um grupo alquenila, onde os ditos grupos alquila e alquenila estão opcionalmente substituídos com um ou mais grupos R¬ 8¬; ou R¬ 3¬ e R¬ 4¬, e/ou R¬ 5¬ e R¬ 6¬ juntos representam =O; R¬ 7¬ é H, R¬ 8¬, NH(CH~ 2~)~ n~R¬ 9¬, CO(CH~ 2~)~ n~R¬ 9¬, NHCO(CH~ 2~)~ n~R¬ 9¬, O(CH~ 2~)~ n~R¬ 9¬, ou um grupo alquila ou fenila, cada um dos quais está opcionalmente substituído com um ou mais grupos selecionados de R¬ 8¬ e R¬ 9¬; R¬ 8¬ é OR¬ 10¬, NR¬ 10¬R¬ 11¬, halogênio, CF~ 3~, NO~ 2~, COR¬ 10¬, CN, COOR¬ 10¬, CONR¬ 10¬R¬ 11¬, SO~ 2~R¬ 10¬ ou SO~ 2~NR¬ 10¬R¬ 11¬; R¬ 9¬ é um grupo cíclico de 5 ou 6 membros, saturado ou insaturado opcionalmente contendo um ou mais heteroátomos selecionados de N, O e S, e opcionalmente substituído com um ou mais grupos R¬ 8¬; R¬ 10¬, R¬ 11¬, R¬ 12¬ e R¬ 13¬ são cada um independentemente H ou um grupo hidrocarbila; e n é 0, 1, 2 ou 3. Ainda aspectos da invenção referem-se a composições farmacêuticas compreendendo compostos de fórmula (1), e seu uso terapêutico no tratamento de distúrbios proliferativos, distúrbios virais, distúrbios de SNC, diabetes, acidente vascular cerebral e distúrbios cardiovasculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0315966.2A GB0315966D0 (en) | 2003-07-08 | 2003-07-08 | Compounds |
PCT/GB2004/002935 WO2005005438A1 (en) | 2003-07-08 | 2004-07-07 | Thiazolo-, oxazalo and imidazolo-quinazoline compounds capable of inhibiting prot ein kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412363A true BRPI0412363A (pt) | 2006-09-05 |
Family
ID=27741793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412363-8A BRPI0412363A (pt) | 2003-07-08 | 2004-07-07 | compostos tiazol-, oxazol e imidazol - quinazolina capazes de inibirem proteìnas cinases |
Country Status (12)
Country | Link |
---|---|
US (1) | US7576091B2 (pt) |
EP (1) | EP1641805B1 (pt) |
JP (1) | JP4653741B2 (pt) |
CN (1) | CN100404540C (pt) |
AT (1) | ATE455119T1 (pt) |
AU (1) | AU2004255924B8 (pt) |
BR (1) | BRPI0412363A (pt) |
CA (1) | CA2530455A1 (pt) |
DE (1) | DE602004025112D1 (pt) |
GB (1) | GB0315966D0 (pt) |
IL (1) | IL172993A0 (pt) |
WO (1) | WO2005005438A1 (pt) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
GB0219052D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
GB0226583D0 (en) * | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
GB0229581D0 (en) * | 2002-12-19 | 2003-01-22 | Cyclacel Ltd | Use |
CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
WO2006040279A1 (de) | 2004-10-07 | 2006-04-20 | Boehringer Ingelheim International Gmbh | Pi3-kinasen |
EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
DE102005048072A1 (de) * | 2005-09-24 | 2007-04-05 | Bayer Cropscience Ag | Thiazole als Fungizide |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
DE102006001161A1 (de) * | 2006-01-06 | 2007-07-12 | Qiagen Gmbh | Verfahren zum Nachweis von Cytosin-Methylierungen |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
US7691868B2 (en) | 2006-04-06 | 2010-04-06 | Boehringer Ingelheim International Gmbh | Thiazolyl-dihydro-quinazoline |
US7517995B2 (en) | 2006-04-06 | 2009-04-14 | Boehringer Ingelheim International Gmbh | Thiazolyl-dihydro-cyclopentapyrazole |
JP5313875B2 (ja) * | 2006-04-12 | 2013-10-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | 増殖性疾患の処置のためのタンパク質キナーゼplk1の阻害剤として有用な4,5−ジヒドロ−[1,2,4]トリアゾロ[4,3−f]プテリジン |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
SG175609A1 (en) | 2006-10-09 | 2011-11-28 | Takeda Pharmaceutical | Kinase inhibitors |
SI2212297T1 (sl) | 2007-10-12 | 2011-09-30 | Ingenium Pharmaceuticals Gmbh | Inhibitorji protein kinaz |
EP2100894A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
MX2010010975A (es) * | 2008-04-07 | 2010-11-01 | Amgen Inc | Amino piridinas/pirimidinas gem-disustituidas y espirociclicas como inhibidores de ciclo celular. |
JP5579724B2 (ja) * | 2008-10-17 | 2014-08-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ホスファチジルイノシトール−3−キナーゼ(pi−3キナーゼ)阻害剤としてのテトラ−アザ−複素環 |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
AU2010268058A1 (en) | 2009-07-02 | 2012-01-19 | Novartis Ag | 2-carboxamide cycloamino ureas useful as PI3K inhibitors |
NZ627520A (en) | 2010-03-10 | 2015-10-30 | Astrazeneca Ab | 4-phenyl pyridine analogues as protein kinase inhibitors |
WO2013059634A1 (en) | 2011-10-20 | 2013-04-25 | The Regents Of The University Of California | Use of cdk9 inhibitors to reduce cartilage degradation |
CA3000633C (en) | 2014-10-14 | 2023-10-03 | The Regents Of The University Of California | Use of cdk9 and brd4 inhibitors to inhibit inflammation |
US20170283445A1 (en) | 2016-04-05 | 2017-10-05 | University Of South Carolina | Small Molecule Inhibitors Selective For Polo-Like Kinase Proteins |
CN114213421A (zh) * | 2017-04-01 | 2022-03-22 | 晟科药业(江苏)有限公司 | 1h-咪唑[4,5-h]喹唑啉类化合物作为蛋白激酶抑制剂 |
CN111094291B (zh) * | 2017-08-11 | 2022-06-21 | 晟科药业(江苏)有限公司 | 1h-吡唑并[4,3-h]喹唑啉类化合物作为蛋白激酶抑制剂 |
US11162083B2 (en) | 2018-06-14 | 2021-11-02 | University Of South Carolina | Peptide based inhibitors of Raf kinase protein dimerization and kinase activity |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
WO2021023104A1 (zh) * | 2019-08-02 | 2021-02-11 | 成都赛诺希亚生物科技有限公司 | 1h-[1,2,3]三唑并[4,5-h]喹唑啉类化合物作为蛋白激酶抑制剂 |
EP4013750A1 (en) | 2019-08-14 | 2022-06-22 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
JOP20220087A1 (ar) | 2019-10-11 | 2023-01-30 | Incyte Corp | أمينات ثنائية الحلقة كمثبطات لـ cdk2 |
CN116601155A (zh) * | 2020-11-26 | 2023-08-15 | 成都赛璟生物医药科技有限公司 | 杂芳基并喹唑啉类化合物作为蛋白激酶抑制剂 |
US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL112248A0 (en) * | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
US5654307A (en) * | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
HUP0300382A3 (en) * | 2000-03-29 | 2006-11-28 | Cyclacel Ltd | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatmetn of proliferative disorders and pharmaceutical compositions containing the compounds |
IL156368A0 (en) * | 2000-12-21 | 2004-01-04 | Vertex Pharma | Pyrazole derivatives and pharmaceutical compositions containing the same |
-
2003
- 2003-07-08 GB GBGB0315966.2A patent/GB0315966D0/en not_active Ceased
-
2004
- 2004-07-07 JP JP2006518353A patent/JP4653741B2/ja not_active Expired - Fee Related
- 2004-07-07 AT AT04743278T patent/ATE455119T1/de not_active IP Right Cessation
- 2004-07-07 EP EP04743278A patent/EP1641805B1/en not_active Not-in-force
- 2004-07-07 DE DE602004025112T patent/DE602004025112D1/de not_active Expired - Fee Related
- 2004-07-07 CA CA002530455A patent/CA2530455A1/en not_active Abandoned
- 2004-07-07 WO PCT/GB2004/002935 patent/WO2005005438A1/en active Application Filing
- 2004-07-07 AU AU2004255924A patent/AU2004255924B8/en not_active Expired - Fee Related
- 2004-07-07 CN CNB2004800257284A patent/CN100404540C/zh not_active Expired - Fee Related
- 2004-07-07 BR BRPI0412363-8A patent/BRPI0412363A/pt not_active IP Right Cessation
-
2006
- 2006-01-05 IL IL172993A patent/IL172993A0/en unknown
- 2006-01-06 US US11/326,805 patent/US7576091B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE455119T1 (de) | 2010-01-15 |
IL172993A0 (en) | 2006-06-11 |
WO2005005438A1 (en) | 2005-01-20 |
CA2530455A1 (en) | 2005-01-20 |
US7576091B2 (en) | 2009-08-18 |
CN1849325A (zh) | 2006-10-18 |
EP1641805A1 (en) | 2006-04-05 |
AU2004255924A1 (en) | 2005-01-20 |
CN100404540C (zh) | 2008-07-23 |
DE602004025112D1 (de) | 2010-03-04 |
GB0315966D0 (en) | 2003-08-13 |
JP2007516202A (ja) | 2007-06-21 |
AU2004255924B8 (en) | 2009-07-09 |
EP1641805B1 (en) | 2010-01-13 |
AU2004255924B2 (en) | 2009-07-02 |
JP4653741B2 (ja) | 2011-03-16 |
US20060264628A1 (en) | 2006-11-23 |
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