BRPI0410332B1 - CEPA DE ESCHERICHIA COLI aroA- E COMPOSIÇÃO DE VACINA COMPREENDENDO A MESMA - Google Patents
CEPA DE ESCHERICHIA COLI aroA- E COMPOSIÇÃO DE VACINA COMPREENDENDO A MESMA Download PDFInfo
- Publication number
- BRPI0410332B1 BRPI0410332B1 BRPI0410332-7A BRPI0410332A BRPI0410332B1 BR PI0410332 B1 BRPI0410332 B1 BR PI0410332B1 BR PI0410332 A BRPI0410332 A BR PI0410332A BR PI0410332 B1 BRPI0410332 B1 BR PI0410332B1
- Authority
- BR
- Brazil
- Prior art keywords
- coli
- birds
- fact
- cfu
- mutant strain
- Prior art date
Links
- 241000588724 Escherichia coli Species 0.000 title claims abstract description 121
- 229960005486 vaccine Drugs 0.000 title claims abstract description 78
- 239000000203 mixture Substances 0.000 title claims description 12
- 241000287828 Gallus gallus Species 0.000 claims abstract description 43
- 235000013330 chicken meat Nutrition 0.000 claims abstract description 32
- 244000144977 poultry Species 0.000 claims abstract description 24
- 235000013594 poultry meat Nutrition 0.000 claims abstract description 24
- 239000003651 drinking water Substances 0.000 claims abstract description 23
- 235000020188 drinking water Nutrition 0.000 claims abstract description 23
- 239000007921 spray Substances 0.000 claims abstract description 23
- 241000286209 Phasianidae Species 0.000 claims abstract description 14
- 241000271566 Aves Species 0.000 claims description 122
- 208000035484 Cellulite Diseases 0.000 claims description 19
- 206010049752 Peau d'orange Diseases 0.000 claims description 19
- 230000036232 cellulite Effects 0.000 claims description 19
- 101150037081 aroA gene Proteins 0.000 claims description 13
- 230000002265 prevention Effects 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 241000272517 Anseriformes Species 0.000 claims description 6
- -1 aromatic amino acid Chemical class 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 241000272201 Columbiformes Species 0.000 claims description 2
- 239000003855 balanced salt solution Substances 0.000 claims description 2
- 239000003104 tissue culture media Substances 0.000 claims description 2
- 230000007812 deficiency Effects 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 abstract description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 6
- 230000006378 damage Effects 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 27
- 230000003902 lesion Effects 0.000 description 16
- 238000002255 vaccination Methods 0.000 description 16
- 241000059485 Escherichia coli O78 Species 0.000 description 14
- 208000008494 pericarditis Diseases 0.000 description 11
- 206010003246 arthritis Diseases 0.000 description 10
- 244000005700 microbiome Species 0.000 description 9
- 238000011156 evaluation Methods 0.000 description 8
- 241001167018 Aroa Species 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
- 101100491986 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) aromA gene Proteins 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 230000002458 infectious effect Effects 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 206010040047 Sepsis Diseases 0.000 description 4
- 230000003449 preventive effect Effects 0.000 description 4
- 208000013223 septicemia Diseases 0.000 description 4
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 3
- 229930182566 Gentamicin Natural products 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 229960002518 gentamicin Drugs 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 229960005322 streptomycin Drugs 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- 206010007882 Cellulitis Diseases 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 241001646716 Escherichia coli K-12 Species 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 229930193140 Neomycin Natural products 0.000 description 2
- 208000010359 Newcastle Disease Diseases 0.000 description 2
- 229960000723 ampicillin Drugs 0.000 description 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 229960001212 bacterial vaccine Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000000546 chi-square test Methods 0.000 description 2
- 229960005091 chloramphenicol Drugs 0.000 description 2
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 239000013599 cloning vector Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000021615 conjugation Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 229960004927 neomycin Drugs 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 210000001113 umbilicus Anatomy 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 210000001325 yolk sac Anatomy 0.000 description 2
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 description 1
- GLDQAMYCGOIJDV-UHFFFAOYSA-M 2,3-dihydroxybenzoate Chemical compound OC1=CC=CC(C([O-])=O)=C1O GLDQAMYCGOIJDV-UHFFFAOYSA-M 0.000 description 1
- FUBFWTUFPGFHOJ-UHFFFAOYSA-N 2-nitrofuran Chemical class [O-][N+](=O)C1=CC=CO1 FUBFWTUFPGFHOJ-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241001516406 Avian orthoreovirus Species 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 208000003495 Coccidiosis Diseases 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 208000008953 Cryptosporidiosis Diseases 0.000 description 1
- 206010011502 Cryptosporidiosis infection Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000078280 Escherichia coli S17 Species 0.000 description 1
- 208000002979 Influenza in Birds Diseases 0.000 description 1
- 206010023076 Isosporiasis Diseases 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 108010093965 Polymyxin B Proteins 0.000 description 1
- GLDQAMYCGOIJDV-UHFFFAOYSA-N Pyrocatechuic acid Natural products OC(=O)C1=CC=CC(O)=C1O GLDQAMYCGOIJDV-UHFFFAOYSA-N 0.000 description 1
- 206010038802 Reticuloendothelial system stimulated Diseases 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000001775 anti-pathogenic effect Effects 0.000 description 1
- 241000701792 avian adenovirus Species 0.000 description 1
- 206010064097 avian influenza Diseases 0.000 description 1
- 208000004668 avian leukosis Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- UUQMNUMQCIQDMZ-UHFFFAOYSA-N betahistine Chemical compound CNCCC1=CC=CC=N1 UUQMNUMQCIQDMZ-UHFFFAOYSA-N 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 208000011090 bird disease Diseases 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 229960000603 cefalotin Drugs 0.000 description 1
- XIURVHNZVLADCM-IUODEOHRSA-N cefalotin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CC1=CC=CS1 XIURVHNZVLADCM-IUODEOHRSA-N 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000004690 coupled electron pair approximation Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 208000010932 epithelial neoplasm Diseases 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 210000003495 flagella Anatomy 0.000 description 1
- 238000012224 gene deletion Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 201000009837 laryngotracheitis Diseases 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229960000210 nalidixic acid Drugs 0.000 description 1
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920000024 polymyxin B Polymers 0.000 description 1
- 229960005266 polymyxin b Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 101150003830 serC gene Proteins 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47047103P | 2003-05-14 | 2003-05-14 | |
| US60/470,471 | 2003-05-14 | ||
| PCT/US2004/014835 WO2004103402A1 (en) | 2003-05-14 | 2004-05-12 | Avian e. coli vaccine for the protection against colibacillosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0410332A BRPI0410332A (pt) | 2006-05-30 |
| BRPI0410332B1 true BRPI0410332B1 (pt) | 2019-10-08 |
Family
ID=33476714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0410332-7A BRPI0410332B1 (pt) | 2003-05-14 | 2004-05-12 | CEPA DE ESCHERICHIA COLI aroA- E COMPOSIÇÃO DE VACINA COMPREENDENDO A MESMA |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7357935B2 (h) |
| EP (1) | EP1622642B1 (h) |
| JP (2) | JP5334029B2 (h) |
| KR (1) | KR101106024B1 (h) |
| CN (1) | CN100387299C (h) |
| AR (1) | AR044338A1 (h) |
| AT (1) | ATE380557T1 (h) |
| AU (1) | AU2004240584B2 (h) |
| BE (1) | BE2012C053I2 (h) |
| BR (1) | BRPI0410332B1 (h) |
| CA (1) | CA2524942C (h) |
| CO (1) | CO5640040A2 (h) |
| CY (1) | CY1107188T1 (h) |
| DE (1) | DE602004010643T2 (h) |
| DK (1) | DK1622642T3 (h) |
| ES (1) | ES2297448T3 (h) |
| FR (1) | FR12C0073I2 (h) |
| HR (1) | HRP20080069T3 (h) |
| HU (1) | HUS1200029I1 (h) |
| MX (1) | MXPA05012218A (h) |
| NZ (1) | NZ543559A (h) |
| PL (1) | PL1622642T3 (h) |
| PT (1) | PT1622642E (h) |
| SI (1) | SI1622642T1 (h) |
| TW (1) | TW200505475A (h) |
| WO (1) | WO2004103402A1 (h) |
| ZA (1) | ZA200509979B (h) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7297338B2 (en) * | 2003-05-14 | 2007-11-20 | Wyeth | Avian vaccine composition for the protection of poultry against disease and infection caused by E. coli and Salmonella |
| CN101575586B (zh) * | 2009-05-31 | 2011-01-19 | 华中农业大学 | 一种支气管败血波氏杆菌基因缺失疫苗及应用 |
| KR101321501B1 (ko) * | 2011-09-21 | 2013-10-29 | 주식회사 바이오포아 | 조류 대장균증 백신 조성물 및 이의 제조방법 |
| BRPI1105176A2 (pt) * | 2011-11-22 | 2013-09-10 | Unicamp | linhagens de escherichia coli, atenuadas para septicemia em aves, vacinas produzidas com essas linhagensm, metodo de produÇço de vacinas e seus usos |
| US9814769B2 (en) | 2014-09-30 | 2017-11-14 | Qatar University | Vaccines against pathogenic Escherichia coli and methods of using the same |
| CN106465698A (zh) * | 2016-09-24 | 2017-03-01 | 王德 | 一种预防雏鸡大肠杆菌病的方法 |
| CN106987549B (zh) * | 2017-04-26 | 2020-08-21 | 河北科星药业有限公司 | 培养基及相应的预防禽类大肠杆菌病的广谱菌苗的生产方法 |
| KR20190070457A (ko) | 2017-12-13 | 2019-06-21 | 주식회사 오투파워 | 이산화염소를 포함하는 닭 대장균증 예방을 위한 음용수 첨가용 조성물 |
| CN112442473B (zh) * | 2020-12-02 | 2022-10-25 | 青岛易邦生物工程有限公司 | 一种禽大肠杆菌疫苗株 |
| CN112494641B (zh) * | 2020-12-02 | 2022-07-05 | 青岛易邦生物工程有限公司 | 一种禽大肠杆菌活疫苗 |
| CN112695004A (zh) * | 2020-12-28 | 2021-04-23 | 南通大学 | APEC双基因rpoS和arcA缺失菌株及弱毒疫苗 |
| EP4252770A1 (en) | 2022-04-01 | 2023-10-04 | Veterinärmedizinische Universität Wien | Composition comprising irradiated e. coli |
| CN116024151B (zh) * | 2022-12-13 | 2024-01-26 | 南通大学 | 一种禽致病性大肠杆菌sRNA s078基因缺失菌株及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0040958B1 (en) | 1980-05-26 | 1984-03-14 | Ici Australia Limited | Process for the synthesis of gamma-unsaturated carboxylic acid esters |
| JPH085802B2 (ja) | 1986-08-13 | 1996-01-24 | 日清製粉株式会社 | 家禽大腸菌症ワクチン |
| GB8912330D0 (en) | 1989-05-30 | 1989-07-12 | Wellcome Found | Live vaccines |
| US5641491A (en) | 1993-06-15 | 1997-06-24 | The Penn State Research Foundation | Escherichia coli strain 364 and use of said strain as a vaccine |
| JPH07206705A (ja) | 1993-11-03 | 1995-08-08 | American Cyanamid Co | 生インオボ（ｉｎ ｏｖｏ）ワクチン |
| WO1998046725A2 (en) * | 1997-04-11 | 1998-10-22 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Attenuated, invasive vaccines against fish pathogens |
| GB9806449D0 (en) | 1998-03-25 | 1998-05-27 | Peptide Therapeutics Ltd | Attenuated bacteria useful in vaccines |
| US7297338B2 (en) | 2003-05-14 | 2007-11-20 | Wyeth | Avian vaccine composition for the protection of poultry against disease and infection caused by E. coli and Salmonella |
-
2004
- 2004-05-03 US US10/837,793 patent/US7357935B2/en not_active Expired - Lifetime
- 2004-05-05 TW TW093112639A patent/TW200505475A/zh unknown
- 2004-05-12 BR BRPI0410332-7A patent/BRPI0410332B1/pt active IP Right Grant
- 2004-05-12 AU AU2004240584A patent/AU2004240584B2/en not_active Expired
- 2004-05-12 PT PT04751979T patent/PT1622642E/pt unknown
- 2004-05-12 JP JP2006532982A patent/JP5334029B2/ja not_active Expired - Lifetime
- 2004-05-12 SI SI200430607T patent/SI1622642T1/sl unknown
- 2004-05-12 CN CNB2004800202756A patent/CN100387299C/zh not_active Expired - Lifetime
- 2004-05-12 PL PL04751979T patent/PL1622642T3/pl unknown
- 2004-05-12 WO PCT/US2004/014835 patent/WO2004103402A1/en active IP Right Grant
- 2004-05-12 AT AT04751979T patent/ATE380557T1/de active
- 2004-05-12 DE DE602004010643T patent/DE602004010643T2/de not_active Expired - Lifetime
- 2004-05-12 NZ NZ543559A patent/NZ543559A/en not_active IP Right Cessation
- 2004-05-12 MX MXPA05012218A patent/MXPA05012218A/es active IP Right Grant
- 2004-05-12 ES ES04751979T patent/ES2297448T3/es not_active Expired - Lifetime
- 2004-05-12 CA CA2524942A patent/CA2524942C/en not_active Expired - Lifetime
- 2004-05-12 HR HR20080069T patent/HRP20080069T3/xx unknown
- 2004-05-12 DK DK04751979T patent/DK1622642T3/da active
- 2004-05-12 EP EP04751979A patent/EP1622642B1/en not_active Expired - Lifetime
- 2004-05-12 KR KR1020057021670A patent/KR101106024B1/ko not_active Expired - Lifetime
- 2004-05-14 AR ARP040101654A patent/AR044338A1/es not_active Application Discontinuation
-
2005
- 2005-11-10 CO CO05114668A patent/CO5640040A2/es active IP Right Grant
- 2005-12-08 ZA ZA200509979A patent/ZA200509979B/xx unknown
-
2008
- 2008-02-13 CY CY20081100163T patent/CY1107188T1/el unknown
- 2008-03-07 US US12/044,549 patent/US7575754B2/en not_active Expired - Lifetime
-
2011
- 2011-06-08 JP JP2011128608A patent/JP2011234721A/ja active Pending
-
2012
- 2012-12-10 FR FR12C0073C patent/FR12C0073I2/fr active Active
- 2012-12-12 HU HUS1200029C patent/HUS1200029I1/hu unknown
- 2012-12-17 BE BE2012C053C patent/BE2012C053I2/fr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7575754B2 (en) | Avian E. coli vaccine for protection against colibacillosis | |
| US6866847B1 (en) | Method of delivering a protein to poultry | |
| US6231871B1 (en) | Live in ovo vaccine | |
| WO2012092226A1 (en) | Veterinary vaccine composition against infections caused by salmonella | |
| JP2012131796A (ja) | エシェリキア・コリおよびサルモネラに対する鳥用混合ワクチン | |
| BRPI0819149B1 (pt) | Vacina de mycoplasma bovis | |
| US20020012672A1 (en) | Live vaccine against colibacillosis | |
| HK1083597B (en) | Avian e. coli vaccine for the protection against colibacillosis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: WYETH LLC. (US) |
|
| B25A | Requested transfer of rights approved |
Owner name: PAH W LLC (US) |
|
| B25D | Requested change of name of applicant approved |
Owner name: ZOETIS W LLC (US) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 18, 25 DA LPI |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: ZOETIS SERVICES LLC (US) |
|
| B25G | Requested change of headquarter approved |
Owner name: ZOETIS SERVICES LLC (US) |
|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2019, OBSERVADAS AS CONDICOES LEGAIS |