BR9916331A - Derivado dos ácidos beta-amido ou beta-sulfonamido carboxìlico, uso do mesmo, preparação farmacêutica para administração oral, parenteral e intraperitoneal, composto, uso deste, e, fragmento estrutura - Google Patents

Derivado dos ácidos beta-amido ou beta-sulfonamido carboxìlico, uso do mesmo, preparação farmacêutica para administração oral, parenteral e intraperitoneal, composto, uso deste, e, fragmento estrutura

Info

Publication number
BR9916331A
BR9916331A BR9916331-4A BR9916331A BR9916331A BR 9916331 A BR9916331 A BR 9916331A BR 9916331 A BR9916331 A BR 9916331A BR 9916331 A BR9916331 A BR 9916331A
Authority
BR
Brazil
Prior art keywords
beta
nitrogen
starch
oral
derived
Prior art date
Application number
BR9916331-4A
Other languages
English (en)
Inventor
Wilhelm Amberg
Rolf Jansen
Georg Kettschau
Hartmut Riechers
Ernst Baumann
Stefan Hergenr Der
Manfred Raschack
Liliane Unger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR9916331A publication Critical patent/BR9916331A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADO DOS áCIDOS BETA-AMIDO OU BETA-SULFONAMIDO CARBOXìLICO, USO DO MESMO, PREPARAçãO FARMACêUTICA PARA ADMINISTRAçãO ORAL, PARENTERAL E INTRAPERITONEAL, COMPOSTO, USO DESTE, E, FRAGMENTO ESTRUTURAL". A invenção diz respeito a derivados de ácido carboxílico da fórmula (I): na qual os substituintes têm os seguintes significados: R¹ é tetrazol ou um grupo (a); W e Z, podem ser idênticos ou diferentes e são nitrogênio ou metina, contanto que, se W e Z são metina, então Q é nitrogênio; X é nitrogênio ou CR^ 9^; Y é nitrogênio ou CR^ 10^; Q é nitrogênio ou CR^ 11^, contanto que, se Q é nitrogênio então X é CR^ 5^ e Y é CR^ 10^; R² e R³ são idênticos ou diferentes e são, possivelmente fenila ou naftila substituídas ou fenila ou naftila que são ligadas em um posição orto por uma ligação direta, um grupo metileno, etileno ou etenileno, um átomo de oxigênio ou de enxofre ou um grupo SO~ 2~-, NH- ou N-alquila ou possivelmente cicloalquila C~ 5~-C~ 6~ substituída; R^ 4^ é um resto de (b) ou (c); e R^ 5^ é hidrogênio, alquila C~ 1~-C~ 4~. A invenção ainda diz respeito a sua preparação e ao seu uso como antagonistas do receptor de endotelina. A invenção também diz respeito a compostos da fórmula (II) e a um fragmento estrutural da fórmula (d) em que os restos de R¹, R², R³, R^ 4^ e R^ 5^ têm os significados dados na reivindicação no. 1 e a seu uso como elementos estruturais em um antagonista do receptor de endotelina.
BR9916331-4A 1998-12-18 1999-12-09 Derivado dos ácidos beta-amido ou beta-sulfonamido carboxìlico, uso do mesmo, preparação farmacêutica para administração oral, parenteral e intraperitoneal, composto, uso deste, e, fragmento estrutura BR9916331A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19858779A DE19858779A1 (de) 1998-12-18 1998-12-18 Neue ß-Amido und ß-Sulfonamidocarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
PCT/EP1999/009679 WO2000037450A1 (de) 1998-12-18 1999-12-09 NEUE β-AMIDO- UND β-SULFONAMIDOCARBONSÄUREDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS ENDOTHELIN-REZEPTORANTAGONISTEN

Publications (1)

Publication Number Publication Date
BR9916331A true BR9916331A (pt) 2001-09-11

Family

ID=7891778

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916331-4A BR9916331A (pt) 1998-12-18 1999-12-09 Derivado dos ácidos beta-amido ou beta-sulfonamido carboxìlico, uso do mesmo, preparação farmacêutica para administração oral, parenteral e intraperitoneal, composto, uso deste, e, fragmento estrutura

Country Status (18)

Country Link
EP (1) EP1140867A1 (pt)
JP (1) JP2002533330A (pt)
KR (1) KR20010101279A (pt)
CN (1) CN1334806A (pt)
AR (1) AR023353A1 (pt)
AU (1) AU3036400A (pt)
BG (1) BG105618A (pt)
BR (1) BR9916331A (pt)
CA (1) CA2355251A1 (pt)
CZ (1) CZ20012186A3 (pt)
DE (1) DE19858779A1 (pt)
HK (1) HK1042095A1 (pt)
HU (1) HUP0201321A3 (pt)
IL (1) IL143451A0 (pt)
NO (1) NO20013000L (pt)
SK (1) SK8682001A3 (pt)
TR (1) TR200101780T2 (pt)
WO (1) WO2000037450A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004522710A (ja) * 2000-11-17 2004-07-29 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 性機能障害の治療
US7790770B2 (en) 2005-11-23 2010-09-07 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
WO2011004402A2 (en) * 2009-07-10 2011-01-13 Cadila Healthcare Limited Improved process for the preparation of ambrisentan and novel intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8912700D0 (en) * 1989-06-02 1989-07-19 Shell Int Research Herbicidal compounds
DE4329911A1 (de) * 1993-09-04 1995-03-09 Basf Ag Substituierte Milchsäurederivate mit einem N-organischen Rest in beta-Position
JP2001506243A (ja) * 1996-12-18 2001-05-15 ビーエーエスエフ アクチェンゲゼルシャフト 複素環式カルボン酸誘導体、その製造およびエンドセリン受容体拮抗物質としての使用
DE19726146A1 (de) * 1997-06-19 1998-12-24 Basf Ag Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten

Also Published As

Publication number Publication date
IL143451A0 (en) 2002-04-21
NO20013000L (no) 2001-08-15
CN1334806A (zh) 2002-02-06
HK1042095A1 (zh) 2002-08-02
TR200101780T2 (tr) 2001-11-21
KR20010101279A (ko) 2001-11-14
AU3036400A (en) 2000-07-12
AR023353A1 (es) 2002-09-04
HUP0201321A3 (en) 2003-02-28
DE19858779A1 (de) 2000-06-21
HUP0201321A2 (hu) 2002-12-28
EP1140867A1 (de) 2001-10-10
BG105618A (en) 2002-01-31
CA2355251A1 (en) 2000-06-29
CZ20012186A3 (cs) 2002-07-17
JP2002533330A (ja) 2002-10-08
NO20013000D0 (no) 2001-06-15
WO2000037450A1 (de) 2000-06-29
SK8682001A3 (en) 2002-08-06

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]