BR9914838A - Processo para preparar cristais altamente estáveis (cristais do tipo a) de éster metìlico de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina - Google Patents

Processo para preparar cristais altamente estáveis (cristais do tipo a) de éster metìlico de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina

Info

Publication number
BR9914838A
BR9914838A BR9914838-2A BR9914838A BR9914838A BR 9914838 A BR9914838 A BR 9914838A BR 9914838 A BR9914838 A BR 9914838A BR 9914838 A BR9914838 A BR 9914838A
Authority
BR
Brazil
Prior art keywords
crystals
type
dimethylbutyl
crystal
alpha
Prior art date
Application number
BR9914838-2A
Other languages
English (en)
Inventor
Shigeru Kawahara
Akihiro Kishishita
Kazutaka Nagashima
Tadashi Takemoto
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10310228A external-priority patent/JP2000136198A/ja
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR9914838A publication Critical patent/BR9914838A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06104Dipeptides with the first amino acid being acidic
    • C07K5/06113Asp- or Asn-amino acid
    • C07K5/06121Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Seasonings (AREA)

Abstract

"PROCESSO PARA PREPARAR CRISTAIS ALTAMENTE ESTáVEIS ( CRISTAIS DO TIPO A) DE éSTER METìLICO DE N-[N-(3,3-DIMETILBUTIL)-L-ALFA-ASPARTIL]-L-FENILALANINA". Um processo para preparar o cristal do tipo A de N-(3,3-dimetilbutil)-APM, sendo excelente em estabilidade, que compreende manter o seu cristal do tipo B sob uma circunstância controlada de uma umidade absoluta de 0,203 kg/kg ou inferior, e uma temperatura do material de 25 a 80°C, para dessa forma originar a transição de cristal; e um processo para preparar o cristais do tipo A de N-(3,3-dimetilbutil)-APM compreendendo manter o seu cristal do tipo D sob uma circunstância controlada de uma umidade absoluta de 0,0550 kg/kg ou inferior, e uma temperatura do material de 25 a 80°C, para dessa forma dar origem à transição de cristal. Estes processos de transição de cristal possibilitam a preparação de um cristal excelente em estabilidade, por um baixo custo e com estabilidade.
BR9914838-2A 1998-10-30 1999-11-01 Processo para preparar cristais altamente estáveis (cristais do tipo a) de éster metìlico de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina BR9914838A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31022798 1998-10-30
JP10310228A JP2000136198A (ja) 1998-10-30 1998-10-30 安定性に優れたアスパルテーム誘導体結晶の製造方法
PCT/JP1999/006083 WO2000026235A1 (fr) 1998-10-30 1999-11-01 Procede de preparation de cristaux de derive d'aspartame possedant une excellente stabilite

Publications (1)

Publication Number Publication Date
BR9914838A true BR9914838A (pt) 2001-08-14

Family

ID=26566235

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914838-2A BR9914838A (pt) 1998-10-30 1999-11-01 Processo para preparar cristais altamente estáveis (cristais do tipo a) de éster metìlico de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina

Country Status (5)

Country Link
KR (1) KR20010075420A (pt)
CN (1) CN1315958A (pt)
BR (1) BR9914838A (pt)
CA (1) CA2348162A1 (pt)
WO (1) WO2000026235A1 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0362706B1 (en) * 1988-10-03 1996-01-17 Ajinomoto Co., Inc. Process for preparing dry IB type crystals of alpha-L-aspartyl-L-phenylalanine methyl ester having improved solubility
FR2719591B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Nouveau composé utile comme agent édulcorant, son procédé de préparation.
FR2719590B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.

Also Published As

Publication number Publication date
WO2000026235A1 (fr) 2000-05-11
CA2348162A1 (en) 2000-05-11
KR20010075420A (ko) 2001-08-09
CN1315958A (zh) 2001-10-03

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired