BR9912587A - Processo sistema e dispositivo para realçar a absorção celular de uma substância, processos para realçar a transfecção de gene de um gene transferido para uma região alvo do corpo de um paciente e para promover a angiogênese em membros isquêmicos, e, kit - Google Patents

Processo sistema e dispositivo para realçar a absorção celular de uma substância, processos para realçar a transfecção de gene de um gene transferido para uma região alvo do corpo de um paciente e para promover a angiogênese em membros isquêmicos, e, kit

Info

Publication number
BR9912587A
BR9912587A BR9912587-0A BR9912587A BR9912587A BR 9912587 A BR9912587 A BR 9912587A BR 9912587 A BR9912587 A BR 9912587A BR 9912587 A BR9912587 A BR 9912587A
Authority
BR
Brazil
Prior art keywords
enhancing
target region
substance
patient
gene
Prior art date
Application number
BR9912587-0A
Other languages
English (en)
Inventor
Alex Brisken
Robert Zuk
John Mckenzie
Jeff Isner
Meno Nassi
Original Assignee
Pharmasonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/126,011 external-priority patent/US6464680B1/en
Application filed by Pharmasonics Inc filed Critical Pharmasonics Inc
Publication of BR9912587A publication Critical patent/BR9912587A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Abstract

"PROCESSO. SISTEMA E DISPOSITIVO PARA REALçAR A ABSORçãO CELULAR DE UMA SUBSTâNCIA, PROCESSOS PARA REALçAR A TRANSFECçãO DE GENE DE UM GENE TRANSFERIDO PARA UMA REGIãO ALVO DO CORPO DE UM PACIENTE E PARA PROMOVER A ANGIOGêNESE EM MEMBROS ISQUêMICOS E, KIT". A invenção é um processo de realçar a absorção celular de uma substância liberada em uma região alvo do corpo de um paciente, que compreende transferir a substância ( 21 ) para a região alvo ( 22 ) e direcionar energia vibracional ( 32 ) para a região alvo, em que a energia vibracional é de um tipo e em uma quantidade suficiente para realçar a absorção nas células ( 24 ) da região alvo.
BR9912587-0A 1998-07-29 1999-07-29 Processo sistema e dispositivo para realçar a absorção celular de uma substância, processos para realçar a transfecção de gene de um gene transferido para uma região alvo do corpo de um paciente e para promover a angiogênese em membros isquêmicos, e, kit BR9912587A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/126,011 US6464680B1 (en) 1998-07-29 1998-07-29 Ultrasonic enhancement of drug injection
US25529099A 1999-02-22 1999-02-22
PCT/US1999/017305 WO2000006032A1 (en) 1998-07-29 1999-07-29 Ultrasonic enhancement of drug injection

Publications (1)

Publication Number Publication Date
BR9912587A true BR9912587A (pt) 2002-06-11

Family

ID=26824191

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912587-0A BR9912587A (pt) 1998-07-29 1999-07-29 Processo sistema e dispositivo para realçar a absorção celular de uma substância, processos para realçar a transfecção de gene de um gene transferido para uma região alvo do corpo de um paciente e para promover a angiogênese em membros isquêmicos, e, kit

Country Status (6)

Country Link
EP (1) EP1107702A4 (pt)
JP (1) JP2002521118A (pt)
AU (1) AU754022B2 (pt)
BR (1) BR9912587A (pt)
CA (1) CA2338396A1 (pt)
WO (1) WO2000006032A1 (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6050943A (en) 1997-10-14 2000-04-18 Guided Therapy Systems, Inc. Imaging, therapy, and temperature monitoring ultrasonic system
CA2361150A1 (en) * 1999-02-22 2000-08-24 Mark W. Cowan Methods and apparatus for uniform transcutaneous therapeutic ultrasound
US7914453B2 (en) 2000-12-28 2011-03-29 Ardent Sound, Inc. Visual imaging system for ultrasonic probe
US6623444B2 (en) * 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
EP1319423A3 (en) * 2001-12-11 2003-10-08 Dornier Medtech System GmbH Apparatus and method for initiating chemical reactions and for the targeted delivery of drugs or other agents
US7358226B2 (en) * 2003-08-27 2008-04-15 The Regents Of The University Of California Ultrasonic concentration of drug delivery capsules
US7393325B2 (en) 2004-09-16 2008-07-01 Guided Therapy Systems, L.L.C. Method and system for ultrasound treatment with a multi-directional transducer
US7824348B2 (en) 2004-09-16 2010-11-02 Guided Therapy Systems, L.L.C. System and method for variable depth ultrasound treatment
US9011336B2 (en) 2004-09-16 2015-04-21 Guided Therapy Systems, Llc Method and system for combined energy therapy profile
US10864385B2 (en) 2004-09-24 2020-12-15 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US8444562B2 (en) 2004-10-06 2013-05-21 Guided Therapy Systems, Llc System and method for treating muscle, tendon, ligament and cartilage tissue
US8535228B2 (en) 2004-10-06 2013-09-17 Guided Therapy Systems, Llc Method and system for noninvasive face lifts and deep tissue tightening
EP1855759B1 (en) 2004-10-06 2017-03-15 Guided Therapy Systems, L.L.C. System for ultrasound tissue treatment
US8663112B2 (en) 2004-10-06 2014-03-04 Guided Therapy Systems, Llc Methods and systems for fat reduction and/or cellulite treatment
US7758524B2 (en) 2004-10-06 2010-07-20 Guided Therapy Systems, L.L.C. Method and system for ultra-high frequency ultrasound treatment
US8690779B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Noninvasive aesthetic treatment for tightening tissue
US8133180B2 (en) 2004-10-06 2012-03-13 Guided Therapy Systems, L.L.C. Method and system for treating cellulite
US9694212B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, Llc Method and system for ultrasound treatment of skin
US11235179B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc Energy based skin gland treatment
US11883688B2 (en) 2004-10-06 2024-01-30 Guided Therapy Systems, Llc Energy based fat reduction
US20060111744A1 (en) 2004-10-13 2006-05-25 Guided Therapy Systems, L.L.C. Method and system for treatment of sweat glands
EP2279697A3 (en) 2004-10-06 2014-02-19 Guided Therapy Systems, L.L.C. Method and system for non-invasive cosmetic enhancement of blood vessel disorders
US9827449B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US11724133B2 (en) 2004-10-07 2023-08-15 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US11207548B2 (en) 2004-10-07 2021-12-28 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
EP1875327A2 (en) 2005-04-25 2008-01-09 Guided Therapy Systems, L.L.C. Method and system for enhancing computer peripheral saftey
US20070232986A1 (en) * 2006-03-31 2007-10-04 Cytodome, Inc. Low-profile implantable ultrasound array and method for enhancing drug delivery to tissue
US9566454B2 (en) 2006-09-18 2017-02-14 Guided Therapy Systems, Llc Method and sysem for non-ablative acne treatment and prevention
WO2008137942A1 (en) * 2007-05-07 2008-11-13 Guided Therapy Systems, Llc. Methods and systems for modulating medicants using acoustic energy
US20150174388A1 (en) 2007-05-07 2015-06-25 Guided Therapy Systems, Llc Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue
AU2009256007B2 (en) 2008-06-06 2014-04-03 Ulthera, Inc. A system and method for cosmetic treatment and imaging
US8715186B2 (en) 2009-11-24 2014-05-06 Guided Therapy Systems, Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
WO2012018386A2 (en) 2010-08-02 2012-02-09 Guided Therapy Systems, Llc Systems and methods for ultrasound treatment
US9504446B2 (en) 2010-08-02 2016-11-29 Guided Therapy Systems, Llc Systems and methods for coupling an ultrasound source to tissue
US8857438B2 (en) 2010-11-08 2014-10-14 Ulthera, Inc. Devices and methods for acoustic shielding
US20130012816A1 (en) 2011-07-10 2013-01-10 Guided Therapy Systems, Llc Methods and systems for controlling acoustic energy deposition into a medium
EP2731675B1 (en) 2011-07-11 2023-05-03 Guided Therapy Systems, L.L.C. Systems and methods for coupling an ultrasound source to tissue
US9263663B2 (en) 2012-04-13 2016-02-16 Ardent Sound, Inc. Method of making thick film transducer arrays
US9510802B2 (en) 2012-09-21 2016-12-06 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
CN204637350U (zh) 2013-03-08 2015-09-16 奥赛拉公司 美学成像与处理系统、多焦点处理系统和执行美容过程的系统
WO2014146022A2 (en) 2013-03-15 2014-09-18 Guided Therapy Systems Llc Ultrasound treatment device and methods of use
CN106470735B (zh) 2014-04-18 2019-09-20 奥赛拉公司 带式换能器超声治疗
ES2939604T3 (es) 2016-01-18 2023-04-25 Ulthera Inc Dispositivo de ultrasonidos compacto que tiene una matriz de ultrasonidos anular conectada eléctricamente de manera periférica a una placa de circuito impreso flexible
ES2955339T3 (es) 2016-08-16 2023-11-30 Ulthera Inc Sistemas y métodos para el tratamiento cosmético de la piel con ultrasonidos
US11944849B2 (en) 2018-02-20 2024-04-02 Ulthera, Inc. Systems and methods for combined cosmetic treatment of cellulite with ultrasound
WO2021100316A1 (ja) * 2019-11-18 2021-05-27 株式会社カネカ 薬液拡散システムおよび薬液拡散促進装置
CN112023243B (zh) * 2020-09-15 2022-03-25 南京大学 超声循环聚焦发射的透皮给药装置及控制方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5197946A (en) * 1990-06-27 1993-03-30 Shunro Tachibana Injection instrument with ultrasonic oscillating element
US5386837A (en) * 1993-02-01 1995-02-07 Mmtc, Inc. Method for enhancing delivery of chemotherapy employing high-frequency force fields
US5667487A (en) * 1993-04-07 1997-09-16 Henley; Julian L. Ionosonic drug delivery apparatus
US5490840A (en) * 1994-09-26 1996-02-13 General Electric Company Targeted thermal release of drug-polymer conjugates
US5752515A (en) * 1996-08-21 1998-05-19 Brigham & Women's Hospital Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier
WO1998018391A1 (en) * 1996-10-30 1998-05-07 Ekos Corporation Intraluminal wall drug delivery device

Also Published As

Publication number Publication date
AU754022B2 (en) 2002-10-31
WO2000006032A1 (en) 2000-02-10
EP1107702A1 (en) 2001-06-20
AU5245099A (en) 2000-02-21
CA2338396A1 (en) 2000-02-10
EP1107702A4 (en) 2002-10-09
JP2002521118A (ja) 2002-07-16

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