BR9901985A - Processo para a preparação de uma piridina substituìda na posição 2 - Google Patents

Processo para a preparação de uma piridina substituìda na posição 2

Info

Publication number
BR9901985A
BR9901985A BR9901985-0A BR9901985A BR9901985A BR 9901985 A BR9901985 A BR 9901985A BR 9901985 A BR9901985 A BR 9901985A BR 9901985 A BR9901985 A BR 9901985A
Authority
BR
Brazil
Prior art keywords
pyridine
butyl lithium
substituted
preparation
sec
Prior art date
Application number
BR9901985-0A
Other languages
English (en)
Inventor
Martha Jean Kelly
Damian Gerard Weaver
Original Assignee
Rohm & Haas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rohm & Haas filed Critical Rohm & Haas
Publication of BR9901985A publication Critical patent/BR9901985A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE UMA PIRIDINA SUBSTITUìDA NA POSIçãO 2" A invenção refere-se a um processo de preparação de piridinas substituídas na posição 2 via troca metal halogênio, com sec-butil-lítio em 2-bromo-ou 2-iodo-piridinas opcionalmente substituídas. O resultante intermediário lítio-piridina é posto a reagir com um eletrófilo para proporcionar a desejada piridina substituída na posição 2. A substituição do n-butil-lítio por sec-butil-lítio em um tal processo resulta em rendimento e pureza realçados da desejada piridina substituída na posição 2.
BR9901985-0A 1998-05-08 1999-05-07 Processo para a preparação de uma piridina substituìda na posição 2 BR9901985A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8468598P 1998-05-08 1998-05-08

Publications (1)

Publication Number Publication Date
BR9901985A true BR9901985A (pt) 2000-05-02

Family

ID=22186583

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9901985-0A BR9901985A (pt) 1998-05-08 1999-05-07 Processo para a preparação de uma piridina substituìda na posição 2

Country Status (8)

Country Link
US (1) US6054583A (pt)
EP (1) EP0955291B1 (pt)
JP (1) JPH11335353A (pt)
CN (1) CN1114593C (pt)
AU (1) AU748410B2 (pt)
BR (1) BR9901985A (pt)
DE (1) DE69902071T2 (pt)
IL (1) IL129596A (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1253152B1 (en) * 2000-02-02 2009-11-04 Banyu Pharmaceutical Co., Ltd. Method of converting functional group through halogen-metal exchange reaction
EP1270535A3 (de) * 2001-06-20 2004-02-18 Clariant GmbH Verfahren zur Herstellung von substituierten aromatischen Verbindungen
EP1474395B1 (en) * 2002-02-12 2007-10-17 Smithkline Beecham Corporation Nicotinamide derivates useful as p38 inhibitors
US7129360B2 (en) 2003-04-07 2006-10-31 Fmc Corporation Using alkylmetal reagents for directed metalation of azaaromatics
GB0308201D0 (en) * 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
CN102746329A (zh) * 2012-07-02 2012-10-24 盛世泰科生物医药技术(苏州)有限公司 一种4-（1-羟基-1,3二氢-苯并[c][1,2]硼酸-6酚）腈基苯的合成方法
CN111962051B (zh) * 2020-08-21 2022-02-08 广州三孚新材料科技股份有限公司 一种异质结太阳能电池用化学镀铜液及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155117A (en) * 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
GB9409882D0 (en) * 1994-05-18 1994-07-06 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
DE69902071T2 (de) 2002-11-14
AU748410B2 (en) 2002-06-06
CN1238331A (zh) 1999-12-15
EP0955291A1 (en) 1999-11-10
CN1114593C (zh) 2003-07-16
US6054583A (en) 2000-04-25
JPH11335353A (ja) 1999-12-07
AU2500399A (en) 1999-11-18
EP0955291B1 (en) 2002-07-10
IL129596A (en) 2003-10-31
DE69902071D1 (de) 2002-08-14
IL129596A0 (en) 2000-02-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.