BR9816021A - Derivados de ácido alfa-(1-piperazinil) acetamido areno carboxilìco como agentes antidiabéticos - Google Patents
Derivados de ácido alfa-(1-piperazinil) acetamido areno carboxilìco como agentes antidiabéticosInfo
- Publication number
- BR9816021A BR9816021A BR9816021-4A BR9816021A BR9816021A BR 9816021 A BR9816021 A BR 9816021A BR 9816021 A BR9816021 A BR 9816021A BR 9816021 A BR9816021 A BR 9816021A
- Authority
- BR
- Brazil
- Prior art keywords
- alpha
- acid derivatives
- acetamido
- piperazinyl
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE áCIDO ALFA -(1-PIPERAZINIL) ACETAMIDO ARENO CARBOXìLICO COMO AGENTES ANTIDIABéTICOS"<D>. A invenção refere-se a compostos de fórmula genérica (I). Estes compostos são úteis no tratamento de diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9705849A FR2763334A1 (fr) | 1997-05-13 | 1997-05-13 | Derives anthraniliques |
PCT/EP1998/003431 WO1999064407A1 (en) | 1997-05-13 | 1998-06-08 | α-(1-PIPERAZINYL)ACETAMIDO ARENECARBOXYLIC ACID DERIVATIVES AS ANTIDIABETIC AGENTS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9816021A true BR9816021A (pt) | 2001-05-15 |
Family
ID=26070316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9816021-4A BR9816021A (pt) | 1997-05-13 | 1998-06-08 | Derivados de ácido alfa-(1-piperazinil) acetamido areno carboxilìco como agentes antidiabéticos |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN1119338C (pt) |
BR (1) | BR9816021A (pt) |
FR (1) | FR2763334A1 (pt) |
WO (1) | WO1999064407A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA00011889A (es) | 1998-06-02 | 2003-04-25 | Osi Pharm Inc | Composiciones de pirrolo (2,3d) piridina y su uso. |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
JO2390B1 (en) | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
EP1450811B1 (en) | 2001-11-30 | 2009-10-21 | OSI Pharmaceuticals, Inc. | Compounds specific to adenosine A1 and A3 receptors and uses thereof |
CN1620294A (zh) * | 2001-12-20 | 2005-05-25 | Osi药物公司 | 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途 |
AR042067A1 (es) * | 2002-11-27 | 2005-06-08 | Bayer Pharmaceuticals Corp | Derivados de anilinopirazol utiles en el tratamiento de la diabetes |
CN100448869C (zh) * | 2002-11-27 | 2009-01-07 | 拜尔药品公司 | 用于治疗糖尿病的苯胺基吡唑衍生物 |
GB0319124D0 (en) * | 2003-08-14 | 2003-09-17 | Smithkline Beecham Corp | Chemical compounds |
JP2008530074A (ja) * | 2005-02-14 | 2008-08-07 | スミスクライン・ビーチャム・コーポレイション | Hm74a受容体アゴニストとしてのアントラニル酸誘導体 |
CN103804362A (zh) * | 2012-11-12 | 2014-05-21 | 韩文毅 | 一类治疗糖尿病的化合物及其用途 |
IL277071B1 (en) | 2018-03-08 | 2024-03-01 | Incyte Corp | Aminopyrizine diol compounds as PI3K–y inhibitors |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
US11871772B2 (en) * | 2018-08-10 | 2024-01-16 | Firmenich Incorporated | Antagonists of T2R54 and compositions and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2346011A1 (fr) * | 1976-02-02 | 1977-10-28 | Orsymonde | Acetanilido-piperazines |
FR2674522B1 (fr) * | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
FR2693722B1 (fr) * | 1992-07-16 | 1994-10-14 | Meram Lab | Dérivés de la N-cycloalkylpipérazine, procédé d'obtention et compositions pharmaceutiques les contenant. |
FR2707984B1 (fr) * | 1993-07-23 | 1995-09-01 | Adir | Nouvelles pipérazines substituées, leur procédé de préparation et les compositions les contenant. |
WO1996026924A1 (fr) * | 1995-02-28 | 1996-09-06 | Suntory Limited | Derives d'arylpiperidine et d'arylpiperazine et medicaments contenant lesdits derives |
FR2757158B1 (fr) * | 1996-12-18 | 1999-04-02 | Lipha | Nouveaux derives d'acide 4-(1-piperazinyl) benzoique, leur procede de preparation et leurs applications therapeutiques |
-
1997
- 1997-05-13 FR FR9705849A patent/FR2763334A1/fr not_active Withdrawn
-
1998
- 1998-06-08 BR BR9816021-4A patent/BR9816021A/pt not_active IP Right Cessation
- 1998-06-08 WO PCT/EP1998/003431 patent/WO1999064407A1/en not_active Application Discontinuation
- 1998-06-08 CN CN98814107A patent/CN1119338C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2763334A1 (fr) | 1998-11-20 |
CN1119338C (zh) | 2003-08-27 |
WO1999064407A1 (en) | 1999-12-16 |
CN1301259A (zh) | 2001-06-27 |
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Legal Events
Date | Code | Title | Description |
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HHX | Correction |
Free format text: REFERENTE A RENUMERACAO PUBLICADA NA RPI 1579 DE 10/04/2001 SOB O NUMERO PI0005805-0 UMA VEZ QUE A DATA DE DEPOSITO CORRETA E 08/06/98 |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7,8 E 9A ANUIDADES |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007. |