BR9801506A - Compostos de quinolina e quinazolina úteis em terapia. - Google Patents
Compostos de quinolina e quinazolina úteis em terapia.Info
- Publication number
- BR9801506A BR9801506A BR9801506-0A BR9801506A BR9801506A BR 9801506 A BR9801506 A BR 9801506A BR 9801506 A BR9801506 A BR 9801506A BR 9801506 A BR9801506 A BR 9801506A
- Authority
- BR
- Brazil
- Prior art keywords
- chem
- formula
- optionally substituted
- quinoline
- therapy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção:<B>"COMPOSTOS DE QUINOLINA E QUINAZOLINA úTEIS EM TERAPIA"<D>. Compostos de fórmula I, em que R^ 1^ representa alcóxi C~ 1~-C~ 4~ facultativamente substituído por um ou mais átomos de flúor, R^ 2^ representa um grupo arilo ou um grupo heteroarilo, facultativamente substituído por alquilo C~ 1~-C~ 4~ ou SO~ 2~NH~ 2~; R^ 3^ representa um anel heterocíclico de 4, 5, 6 ou 7 membros contendo pelo menos um heteroátomo seleccionado de entre N, O e S, sendo o anel facultativamente condensado com um anel de benzeno ou um anel heterocíclico de 5 ou 6 membros contendo pelo menos um heteroátomo seleccionado de entre N, O e S, sendo o sistema de anel como um conjunto facultativamente substituído; X representa CH ou N; e L está ausente, ou representa um grupo cíclico de fórmula Ia, ou representa uma cadeia de fórmula Ib, e seus sais farmaceuticamente aceitáveis, são úteis no tratamento de uma variedade de desordens que incluem a hiperplasia prostática benigna.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9708917.1A GB9708917D0 (en) | 1997-05-01 | 1997-05-01 | Compounds useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9801506A true BR9801506A (pt) | 2000-02-08 |
Family
ID=10811691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9801506-0A BR9801506A (pt) | 1997-05-01 | 1998-04-29 | Compostos de quinolina e quinazolina úteis em terapia. |
Country Status (10)
Country | Link |
---|---|
US (2) | US6649620B2 (pt) |
EP (1) | EP0875506B1 (pt) |
JP (1) | JP3076786B2 (pt) |
AT (1) | ATE233242T1 (pt) |
BR (1) | BR9801506A (pt) |
CA (1) | CA2236239C (pt) |
DE (1) | DE69811556T2 (pt) |
DK (1) | DK0875506T3 (pt) |
ES (1) | ES2190809T3 (pt) |
GB (1) | GB9708917D0 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9700504D0 (en) * | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
GB9708917D0 (en) * | 1997-05-01 | 1997-06-25 | Pfizer Ltd | Compounds useful in therapy |
AU2478500A (en) | 1998-12-08 | 2000-06-26 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
US6284755B1 (en) | 1998-12-08 | 2001-09-04 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2002352878B2 (en) * | 2001-11-27 | 2007-11-22 | Merck Sharp & Dohme Corp. | 2-Aminoquinoline compounds |
AU2003249212C1 (en) | 2002-07-15 | 2011-10-27 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
ES2371383T3 (es) | 2003-09-26 | 2011-12-30 | Exelixis, Inc. | N-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin-4-ilpropil)oxi]quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida para el tratamiento del cáncer. |
US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
JP4983112B2 (ja) * | 2006-06-28 | 2012-07-25 | 宇部興産株式会社 | 3−(ヒドロキシ又はアルコキシ)−4−アルコキシ−6−ニトロ安息香酸化合物の製法 |
US8735424B2 (en) * | 2008-09-02 | 2014-05-27 | Novartis Ag | Bicyclic kinase inhibitors |
CN110818633A (zh) | 2009-01-16 | 2020-02-21 | 埃克塞里艾克西斯公司 | 一种苹果酸盐及其晶型 |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
ES2916220T3 (es) * | 2012-07-11 | 2022-06-29 | Blueprint Medicines Corp | Inhibidores del receptor de factor de crecimiento de fibroblasto |
ES2924111T3 (es) | 2013-10-25 | 2022-10-04 | Blueprint Medicines Corp | Inhibidores del receptor del factor de crecimiento de fibroblastos |
CN113801069B (zh) * | 2020-06-15 | 2024-03-15 | 鲁南制药集团股份有限公司 | 一种盐酸阿夫唑嗪中间体化合物 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3957791A (en) * | 1972-09-25 | 1976-05-18 | Sandoz, Inc. | Hydroxyalkyl-piperazino-quinoline nitrates |
US3956495A (en) * | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
US4060615A (en) * | 1976-02-18 | 1977-11-29 | Mead Johnson & Company | 2-Piperazinyl-6,7-dimethoxyquinazolines |
US4062844A (en) * | 1976-09-20 | 1977-12-13 | Pfizer Inc. | Process for preparing hypotensive 2-(4-aroylpiperazin-1-yl)-amino-6,7-dimethoxyquinazolines |
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
US4189484A (en) * | 1977-11-08 | 1980-02-19 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | Antihypertensive quinazoline derivatives |
US4287341A (en) * | 1979-11-01 | 1981-09-01 | Pfizer Inc. | Alkoxy-substituted-6-chloro-quinazoline-2,4-diones |
GR79603B (pt) * | 1982-07-24 | 1984-10-31 | Pfizer | |
DE3375395D1 (en) * | 1983-11-22 | 1988-02-25 | Heumann Ludwig & Co Gmbh | Process for the preparation of 4-amino-6,7-dimethoxy-2-(4-(furoyl-2)-piperazin-1-yl)-quinazoline and its physiologically acceptable salt |
GB8506174D0 (en) * | 1985-03-09 | 1985-04-11 | Pfizer Ltd | 4-amino-6 7-dimethoxy-2-piperazin-1-ylquinazoline derivatives |
IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
WO1995007267A1 (fr) * | 1993-09-10 | 1995-03-16 | Eisai Co., Ltd. | Compose de quinazoline |
JPH07206857A (ja) * | 1993-12-28 | 1995-08-08 | Synthelabo Sa | アルフゾシン塩酸塩の二水和物 |
NZ325248A (en) * | 1995-12-23 | 1999-09-29 | Pfizer Res & Dev | Quinoline and quinazoline compounds useful in therapy |
CA2173408C (en) * | 1996-04-03 | 2001-09-04 | K.S. Keshava Murthy | Process for the manufacture of intermediates suitable to make doxazosin,terazosin, prazosin, tiodazosin and related antihypertensive medicines |
GB9700504D0 (en) * | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
US6262269B1 (en) * | 1997-02-04 | 2001-07-17 | Trega Biosciences, Inc. | 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries |
GB9708917D0 (en) * | 1997-05-01 | 1997-06-25 | Pfizer Ltd | Compounds useful in therapy |
GB9711650D0 (en) * | 1997-06-05 | 1997-07-30 | Pfizer Ltd | Compounds useful in therapy |
US6221882B1 (en) * | 1997-07-03 | 2001-04-24 | University Of Iowa Research Foundation | Methods for inhibiting immunostimulatory DNA associated responses |
-
1997
- 1997-05-01 GB GBGB9708917.1A patent/GB9708917D0/en active Pending
-
1998
- 1998-04-16 DK DK98302968T patent/DK0875506T3/da active
- 1998-04-16 DE DE69811556T patent/DE69811556T2/de not_active Expired - Fee Related
- 1998-04-16 AT AT98302968T patent/ATE233242T1/de not_active IP Right Cessation
- 1998-04-16 EP EP98302968A patent/EP0875506B1/en not_active Expired - Lifetime
- 1998-04-16 ES ES98302968T patent/ES2190809T3/es not_active Expired - Lifetime
- 1998-04-29 CA CA002236239A patent/CA2236239C/en not_active Expired - Fee Related
- 1998-04-29 BR BR9801506-0A patent/BR9801506A/pt not_active IP Right Cessation
- 1998-05-01 JP JP10121990A patent/JP3076786B2/ja not_active Expired - Fee Related
-
2002
- 2002-09-23 US US10/252,852 patent/US6649620B2/en not_active Expired - Fee Related
-
2003
- 2003-08-13 US US10/640,314 patent/US20040034032A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2236239A1 (en) | 1998-11-01 |
DE69811556T2 (de) | 2003-08-28 |
US20030045525A1 (en) | 2003-03-06 |
CA2236239C (en) | 2003-03-18 |
GB9708917D0 (en) | 1997-06-25 |
ATE233242T1 (de) | 2003-03-15 |
US6649620B2 (en) | 2003-11-18 |
US20040034032A1 (en) | 2004-02-19 |
ES2190809T3 (es) | 2003-08-16 |
JPH10316664A (ja) | 1998-12-02 |
EP0875506A1 (en) | 1998-11-04 |
JP3076786B2 (ja) | 2000-08-14 |
DE69811556D1 (de) | 2003-04-03 |
DK0875506T3 (da) | 2003-03-31 |
EP0875506B1 (en) | 2003-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1908 DE 31/07/2007. |