BR9712767A - Expressão especìfica para tecido de proteìna de retinoblastoma - Google Patents
Expressão especìfica para tecido de proteìna de retinoblastomaInfo
- Publication number
- BR9712767A BR9712767A BR9712767-1A BR9712767A BR9712767A BR 9712767 A BR9712767 A BR 9712767A BR 9712767 A BR9712767 A BR 9712767A BR 9712767 A BR9712767 A BR 9712767A
- Authority
- BR
- Brazil
- Prior art keywords
- retinoblastoma protein
- protein tissue
- expression specific
- tissue
- retinoblastoma
- Prior art date
Links
- 108050002653 Retinoblastoma protein Proteins 0.000 title abstract 3
- 102000001388 E2F Transcription Factors Human genes 0.000 abstract 1
- 108010093502 E2F Transcription Factors Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4736—Retinoblastoma protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Patente de Invenção:"EXPRESSãO ESPECìFICA PARA TECIDO DE PROTEìNA DE RETINOBLASTOMA"<D>. São fornecidos flusões do fator de transcrição E2F e da proteína de retinoblastoma RB, junto com métodos de tratamento de distúrbios hiperproliferativos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75151796A | 1996-11-15 | 1996-11-15 | |
US751517 | 1996-11-15 | ||
US801092 | 1997-02-14 | ||
US08/801,092 US6074850A (en) | 1996-11-15 | 1997-02-14 | Retinoblastoma fusion polypeptides |
PCT/US1997/021821 WO1998021228A1 (en) | 1996-11-15 | 1997-11-13 | Tissue specific expression of retinoblastoma protein |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9712767A true BR9712767A (pt) | 1999-10-26 |
BR9712767B1 BR9712767B1 (pt) | 2010-11-30 |
Family
ID=27115430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9712767-1A BR9712767B1 (pt) | 1996-11-15 | 1997-11-13 | sequência de ácidos nucléicos codificando um polipeptìdio de fusão bem como vetor compreendendo a dita sequência. |
Country Status (16)
Country | Link |
---|---|
US (2) | US6379927B1 (pt) |
EP (1) | EP0948520B1 (pt) |
JP (1) | JP4109721B2 (pt) |
KR (1) | KR100336551B1 (pt) |
CN (1) | CN100338219C (pt) |
AT (1) | ATE286908T1 (pt) |
AU (1) | AU723660B2 (pt) |
BR (1) | BR9712767B1 (pt) |
CA (1) | CA2271478C (pt) |
DE (1) | DE69732246T2 (pt) |
ES (1) | ES2234040T3 (pt) |
HK (1) | HK1019751A1 (pt) |
HU (1) | HU226662B1 (pt) |
IL (1) | IL129922A0 (pt) |
NZ (1) | NZ335738A (pt) |
WO (1) | WO1998021228A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1054969A2 (en) * | 1998-02-12 | 2000-11-29 | Curagen Corporation | Retinoblastoma protein complexes and retinoblastoma interacting proteins |
US7691370B2 (en) | 1998-10-15 | 2010-04-06 | Canji, Inc. | Selectivity replicating viral vector |
US6649158B1 (en) | 1998-10-15 | 2003-11-18 | Canji, Inc. | Methods and compositions to induce antitumor response |
WO2000022137A2 (en) * | 1998-10-15 | 2000-04-20 | Canji, Inc. | Selectively replicating viral vectors |
WO2000022124A2 (en) * | 1998-10-15 | 2000-04-20 | Canji, Inc. | Methods and compositions to induce antitumor response |
WO2002050101A1 (en) * | 2000-12-19 | 2002-06-27 | The Council Of The Queensland Institute Of Medical Research | Retinoblastoma-binding protein |
US6866994B2 (en) * | 2001-05-30 | 2005-03-15 | Neomatrix, Llc | Noninvasive intraductal fluid diagnostic screen |
CN103463646A (zh) * | 2013-09-19 | 2013-12-25 | 浙江大学 | E2f1蛋白在制备诊断和治疗骨肉瘤药物中的应用 |
CA2936070C (en) * | 2015-07-14 | 2023-07-04 | Professional Compounding Centers Of America (Pcca) | Poloxamer-based intralesional injections for the delivery of chemotherapeutic agents |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
JPH07500961A (ja) | 1990-10-01 | 1995-02-02 | ユニバーシティ オブ コネチカット | 細胞による選択的内在化を目的としたウイルス及び細胞の標的設定 |
AU3434393A (en) | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
CA2133411A1 (en) | 1992-04-03 | 1993-10-14 | Alexander T. YOUNG | Gene therapy using targeted viral vectors |
ATE260679T1 (de) | 1992-04-03 | 2004-03-15 | Univ California | Selbstorganisierendes system zur verabreichung von polynukleotiden enthaltend ein amphiphatisches peptid |
WO1994006923A1 (en) | 1992-09-24 | 1994-03-31 | The University Of Connecticut | Modification of a virus to redirect infectivity and enhance targeted delivery of polynucleotides to cells |
US5656609A (en) | 1992-09-24 | 1997-08-12 | University Of Connecticut | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine |
WO1995007708A2 (en) * | 1993-09-13 | 1995-03-23 | The Regents Of The University Of California | Therapeutic use of the retinoblastoma susceptibility gene product |
US5473056A (en) * | 1993-10-13 | 1995-12-05 | Merck & Co., Inc. | E2F-2, a novel mammalian transcription factor |
-
1997
- 1997-11-13 DE DE69732246T patent/DE69732246T2/de not_active Expired - Lifetime
- 1997-11-13 EP EP97952238A patent/EP0948520B1/en not_active Expired - Lifetime
- 1997-11-13 WO PCT/US1997/021821 patent/WO1998021228A1/en active IP Right Grant
- 1997-11-13 BR BRPI9712767-1A patent/BR9712767B1/pt not_active IP Right Cessation
- 1997-11-13 AT AT97952238T patent/ATE286908T1/de not_active IP Right Cessation
- 1997-11-13 HU HU9903864A patent/HU226662B1/hu not_active IP Right Cessation
- 1997-11-13 CA CA002271478A patent/CA2271478C/en not_active Expired - Fee Related
- 1997-11-13 JP JP52295898A patent/JP4109721B2/ja not_active Expired - Fee Related
- 1997-11-13 ES ES97952238T patent/ES2234040T3/es not_active Expired - Lifetime
- 1997-11-13 KR KR1019997004327A patent/KR100336551B1/ko not_active IP Right Cessation
- 1997-11-13 IL IL12992297A patent/IL129922A0/xx active IP Right Grant
- 1997-11-13 CN CNB971813175A patent/CN100338219C/zh not_active Expired - Fee Related
- 1997-11-13 AU AU55899/98A patent/AU723660B2/en not_active Ceased
- 1997-11-13 NZ NZ335738A patent/NZ335738A/en not_active IP Right Cessation
-
1999
- 1999-05-19 US US09/315,113 patent/US6379927B1/en not_active Expired - Lifetime
- 1999-05-19 US US09/315,116 patent/US6902731B1/en not_active Expired - Fee Related
- 1999-10-15 HK HK99104577A patent/HK1019751A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0948520A4 (en) | 2003-03-12 |
HUP9903864A3 (en) | 2001-09-28 |
AU5589998A (en) | 1998-06-03 |
HK1019751A1 (en) | 2000-02-25 |
ES2234040T3 (es) | 2005-06-16 |
CN1244870A (zh) | 2000-02-16 |
KR20000053323A (ko) | 2000-08-25 |
AU723660B2 (en) | 2000-08-31 |
BR9712767B1 (pt) | 2010-11-30 |
JP2001503638A (ja) | 2001-03-21 |
WO1998021228A1 (en) | 1998-05-22 |
KR100336551B1 (ko) | 2002-05-11 |
US6379927B1 (en) | 2002-04-30 |
EP0948520A1 (en) | 1999-10-13 |
EP0948520B1 (en) | 2005-01-12 |
DE69732246T2 (de) | 2005-12-08 |
CA2271478A1 (en) | 1998-05-22 |
NZ335738A (en) | 2001-02-23 |
US6902731B1 (en) | 2005-06-07 |
HUP9903864A2 (hu) | 2001-04-28 |
IL129922A0 (en) | 2000-02-29 |
CA2271478C (en) | 2003-02-04 |
JP4109721B2 (ja) | 2008-07-02 |
CN100338219C (zh) | 2007-09-19 |
HU226662B1 (en) | 2009-06-29 |
DE69732246D1 (de) | 2005-02-17 |
ATE286908T1 (de) | 2005-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/11/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 18A ANUIDADE. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2342 DE 24-11-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |