BR9708042A - Novas benzotiepinas tendo atividade como inibidores de transporte de ácido de bile ileal e de absorção de taurocolato - Google Patents
Novas benzotiepinas tendo atividade como inibidores de transporte de ácido de bile ileal e de absorção de taurocolatoInfo
- Publication number
- BR9708042A BR9708042A BR9708042A BR9708042A BR9708042A BR 9708042 A BR9708042 A BR 9708042A BR 9708042 A BR9708042 A BR 9708042A BR 9708042 A BR9708042 A BR 9708042A BR 9708042 A BR9708042 A BR 9708042A
- Authority
- BR
- Brazil
- Prior art keywords
- benzothiepines
- inhibitors
- activity
- new
- bile acid
- Prior art date
Links
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
- NIGNBCLEMMGDQP-UHFFFAOYSA-N 1-benzothiepine Chemical class S1C=CC=CC2=CC=CC=C12 NIGNBCLEMMGDQP-UHFFFAOYSA-N 0.000 title 1
- 238000010521 absorption reaction Methods 0.000 title 1
- 239000003613 bile acid Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655381—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring
- C07F9/65539—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1311996P | 1996-03-11 | 1996-03-11 | |
| PCT/US1997/004076 WO1997033882A1 (en) | 1996-03-11 | 1997-03-11 | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9708042A true BR9708042A (pt) | 1999-07-27 |
Family
ID=21758403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9708042A BR9708042A (pt) | 1996-03-11 | 1997-03-11 | Novas benzotiepinas tendo atividade como inibidores de transporte de ácido de bile ileal e de absorção de taurocolato |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR19990087721A (no) |
| AU (1) | AU723123B2 (no) |
| BR (1) | BR9708042A (no) |
| NO (1) | NO984146L (no) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1593760A1 (de) * | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
| CN1084741C (zh) * | 1994-09-13 | 2002-05-15 | 孟山都公司 | 具有回肠胆汁酸转运和牛磺胆酸盐摄入抑制剂作用的新的苯并硫杂䓬 |
-
1997
- 1997-03-11 KR KR1019980707189A patent/KR19990087721A/ko not_active Application Discontinuation
- 1997-03-11 BR BR9708042A patent/BR9708042A/pt not_active Application Discontinuation
- 1997-03-11 AU AU23266/97A patent/AU723123B2/en not_active Ceased
-
1998
- 1998-09-09 NO NO984146A patent/NO984146L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR19990087721A (ko) | 1999-12-27 |
| NO984146D0 (no) | 1998-09-09 |
| AU723123B2 (en) | 2000-08-17 |
| NO984146L (no) | 1998-10-30 |
| AU2326697A (en) | 1997-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL140576A0 (en) | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake | |
| HUP9903047A3 (en) | Novel benzothiazepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake | |
| PL319587A1 (en) | Agents for and methods of treating inflammatory states taking course under participation of fattened tissue | |
| PT796855E (pt) | Inibicao da reabsorcao nos ossos e antagonistas de vitronectina | |
| IL138871A0 (en) | Flushable diaper and method | |
| IL144716A0 (en) | Novel 1,2-benzothiazepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake | |
| PT1140189E (pt) | Combinacoes de inibidores do transporte do acido biliar ileal e de derivados do acido fibrico para indicacoes cardiovasculares | |
| EG20954A (en) | Water dispersible and flushable interlabial absorbent structure | |
| BR9508916A (pt) | "Novas benzotiepinas tendo atividade como inibidores de transporte do ácido biliar ileal e absorção de taurocolato" | |
| DE69504087T2 (de) | Anaerobischer schrank und system | |
| BR9710031A (pt) | Tratamento de incontinência urinária utilizando (s)-Oxibutinina e (s)-Desetiloxibutinina | |
| PT900225E (pt) | Alquil-4-silil-fenois e esteres destes como agentes antiateroscleroticos | |
| EP0788483A4 (en) | 7-SUBSTITUTED 4-AZACHOLANIC ACID DERIVATIVES AND THEIR USE | |
| FR2756335B1 (fr) | Palier magnetique actif longitudinalement et transversalement | |
| IL128101A0 (en) | Detection of mammalian heparanase activity and purification of mammalian heparanase | |
| BR9706902A (pt) | Uso de pelo menos um inibidor da atividade do ácido retinóico e composição | |
| PT935692E (pt) | Tratamento de tecido com celulase e oxidoredutase | |
| BR9708042A (pt) | Novas benzotiepinas tendo atividade como inibidores de transporte de ácido de bile ileal e de absorção de taurocolato | |
| NO984698D0 (no) | FremgangsmÕte for forbrenning av avfall i en forbrenningsovn og for behandling av slagget fra avfallsforbrenningen | |
| PT1066284E (pt) | Derivados de benzo [c] quinolizina e sua utilizacao como inibidores de 5-alfa-redutases | |
| SI1091953T1 (en) | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake | |
| FR2745561B1 (fr) | Procede catalytique de desodorisation et desazotation de rejets polluants | |
| KR960023550U (ko) | 볼트와 와셔의 구조 | |
| BR9305314A (pt) | Unidade transformadora temporizada de disposição introduzida em instalação hidro-sanitária para exaustão de odores de vaso sanitário | |
| KR960004066U (ko) | 인체의 냄새제거 및 살균장치 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |