BR112023026961A2 - Composições e métodos para modular a expressão de genes - Google Patents

Composições e métodos para modular a expressão de genes

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Publication number
BR112023026961A2
BR112023026961A2 BR112023026961A BR112023026961A BR112023026961A2 BR 112023026961 A2 BR112023026961 A2 BR 112023026961A2 BR 112023026961 A BR112023026961 A BR 112023026961A BR 112023026961 A BR112023026961 A BR 112023026961A BR 112023026961 A2 BR112023026961 A2 BR 112023026961A2
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Brazil
Prior art keywords
compositions
rna
methods
gene expression
expression
Prior art date
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BR112023026961A
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English (en)
Inventor
Friedrich Metzger
Antony Selvaraj Justin
Pieter Zuideveld Klaas
Petra Hillmann-Wullner
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Versameb Ag
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Publication date
Application filed by Versameb Ag filed Critical Versameb Ag
Publication of BR112023026961A2 publication Critical patent/BR112023026961A2/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
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Abstract

composições e métodos para modular a expressão de genes. a presente invenção se refere a composições e métodos para modular a expressão de genes, compreendendo construtos de ácido polinucleico ou rna recombinante compreendendo uma primeira sequência de rna que codifica um gene de interesse, e uma segunda sequência de rna compreendendo pelo menos dois elementos genéticos que modulam a expressão de um ou mais rnas alvo. os construtos de rna recombinante descritos na presente invenção induzem uma resposta imune em uma célula humana que é mais baixa do que a resposta imune induzida por um construto de rna recombinante correspondente compreendendo a primeira sequência de rna que codifica um gene de interesse e uma segunda sequência de rna correspondente compreendendo no máximo um de pelo menos dois elementos genéticos. também é revelado na presente invenção o uso das composições no tratamento de doenças e na modulação de expressão de dois ou mais genes.
BR112023026961A 2021-06-23 2022-06-22 Composições e métodos para modular a expressão de genes BR112023026961A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163213829P 2021-06-23 2021-06-23
PCT/IB2022/000358 WO2022269356A2 (en) 2021-06-23 2022-06-22 Compositions and methods for modulating expression of genes

Publications (1)

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BR112023026961A2 true BR112023026961A2 (pt) 2024-03-12

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BR112023026961A BR112023026961A2 (pt) 2021-06-23 2022-06-22 Composições e métodos para modular a expressão de genes

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US (1) US20240117361A1 (pt)
EP (1) EP4359533A2 (pt)
KR (1) KR20240024172A (pt)
CN (1) CN117813380A (pt)
AU (1) AU2022299474A1 (pt)
BR (1) BR112023026961A2 (pt)
CA (1) CA3221277A1 (pt)
IL (1) IL308979A (pt)
TW (1) TW202309288A (pt)
WO (1) WO2022269356A2 (pt)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003529349A (ja) * 2000-02-18 2003-10-07 ロード アイランド ホスピタル， ア ライフスパン パートナー 骨障害の治療
JP5078904B2 (ja) * 2005-11-21 2012-11-21 ジヨンソン・アンド・ジヨンソン・リサーチ・ピーテイワイ・リミテツド 多標的干渉ｒｎａならびにそれらの使用および設計方法
EP1938802A1 (en) * 2006-12-22 2008-07-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Interfering RNAs targeting pro-inflammatory cytokines
EP4006153A1 (en) * 2018-01-12 2022-06-01 Curocell Inc. Enhanced immune cells using dual shrna and composition including the same
EP3898982A2 (en) * 2018-12-19 2021-10-27 Versameb AG Rna encoding a protein
KR20220035326A (ko) * 2019-05-02 2022-03-22 셀리아드 다중화된 억제성 rna를 갖는 세포
BR112022012324A2 (pt) * 2019-12-23 2022-10-11 Versameb Ag Composições e métodos para modular simultaneamente expressão de genes

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Publication number Publication date
CA3221277A1 (en) 2022-12-29
CN117813380A (zh) 2024-04-02
AU2022299474A1 (en) 2023-12-21
TW202309288A (zh) 2023-03-01
US20240117361A1 (en) 2024-04-11
WO2022269356A3 (en) 2023-05-25
IL308979A (en) 2024-01-01
WO2022269356A2 (en) 2022-12-29
KR20240024172A (ko) 2024-02-23
EP4359533A2 (en) 2024-05-01

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