BR112023005623A2 - Composições e métodos para modular simultaneamente expressão de genes - Google Patents

Composições e métodos para modular simultaneamente expressão de genes

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Publication number
BR112023005623A2
BR112023005623A2 BR112023005623A BR112023005623A BR112023005623A2 BR 112023005623 A2 BR112023005623 A2 BR 112023005623A2 BR 112023005623 A BR112023005623 A BR 112023005623A BR 112023005623 A BR112023005623 A BR 112023005623A BR 112023005623 A2 BR112023005623 A2 BR 112023005623A2
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BR
Brazil
Prior art keywords
compositions
methods
gene expression
simultaneously modulate
modulate gene
Prior art date
Application number
BR112023005623A
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English (en)
Inventor
Antony Selvaraj Justin
Pieter Zuideveld Klaas
Schaffhauser Herve
HILLMANN-WULLNER Petra
Metzger Friedrich
Original Assignee
Versameb Ag
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Publication date
Application filed by Versameb Ag filed Critical Versameb Ag
Publication of BR112023005623A2 publication Critical patent/BR112023005623A2/pt

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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract

COMPOSIÇÕES E MÉTODOS PARA MODULAR SIMULTANEAMENTE EXPRESSÃO DE GENES. A presente invenção se refere a composições de construtos de ácido polinucleico recombinantes compreendendo pelo menos uma sequência de ácidos nucleicos que codifica um siRNA capaz de se ligar a um RNAm alvo e pelo menos uma sequência de ácidos nucleicos que codifica um gene de interesse. Também é divulgado, na presente invenção, o uso das composições para tratar cânceres e para modular, simultaneamente, a expressão de dois ou mais genes.
BR112023005623A 2020-10-05 2021-10-04 Composições e métodos para modular simultaneamente expressão de genes BR112023005623A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063087643P 2020-10-05 2020-10-05
US202163213841P 2021-06-23 2021-06-23
PCT/IB2021/000682 WO2022074453A2 (en) 2020-10-05 2021-10-04 Compositions and methods for simultaneously modulating expression of genes

Publications (1)

Publication Number Publication Date
BR112023005623A2 true BR112023005623A2 (pt) 2023-04-25

Family

ID=78709494

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023005623A BR112023005623A2 (pt) 2020-10-05 2021-10-04 Composições e métodos para modular simultaneamente expressão de genes

Country Status (11)

Country Link
US (1) US20230322885A1 (pt)
EP (1) EP4225920A2 (pt)
JP (1) JP2023543915A (pt)
KR (1) KR20230082026A (pt)
AU (1) AU2021356243A1 (pt)
BR (1) BR112023005623A2 (pt)
CA (1) CA3192949A1 (pt)
IL (1) IL301510A (pt)
MX (1) MX2023003925A (pt)
TW (1) TW202228728A (pt)
WO (1) WO2022074453A2 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022269349A2 (en) * 2021-06-23 2022-12-29 Versameb Ag Compositions and methods for modulating expression of genes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008148068A1 (en) * 2007-05-23 2008-12-04 Mannkind Corporation Multicistronic vectors and methods for their design
AU2013203610A1 (en) * 2012-06-20 2014-01-16 The Australian National University Improved Recombinant Viruses
US11230719B2 (en) * 2014-03-26 2022-01-25 Denovo Biopharma Llc Retroviral vector having immune-stimulating activity
WO2019199994A1 (en) * 2018-04-11 2019-10-17 Cancer Targeting Systems, Inc. Therapeutic constructs for treating cancer
WO2019213550A1 (en) * 2018-05-03 2019-11-07 Duke University Vaccine compositions and methods for enhanced antigen-specific vaccination
KR20220121844A (ko) * 2019-12-23 2022-09-01 베르사멥 아게 유전자의 발현을 동시에 조절하기 위한 조성물 및 방법

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Publication number Publication date
KR20230082026A (ko) 2023-06-08
MX2023003925A (es) 2023-05-08
TW202228728A (zh) 2022-08-01
WO2022074453A2 (en) 2022-04-14
IL301510A (en) 2023-05-01
EP4225920A2 (en) 2023-08-16
AU2021356243A1 (en) 2023-06-08
JP2023543915A (ja) 2023-10-18
US20230322885A1 (en) 2023-10-12
WO2022074453A3 (en) 2022-06-09
CA3192949A1 (en) 2022-04-14

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