BR112023025327A2 - Método para tratar uma condição que requer tratamento inotrópico - Google Patents
Método para tratar uma condição que requer tratamento inotrópicoInfo
- Publication number
- BR112023025327A2 BR112023025327A2 BR112023025327A BR112023025327A BR112023025327A2 BR 112023025327 A2 BR112023025327 A2 BR 112023025327A2 BR 112023025327 A BR112023025327 A BR 112023025327A BR 112023025327 A BR112023025327 A BR 112023025327A BR 112023025327 A2 BR112023025327 A2 BR 112023025327A2
- Authority
- BR
- Brazil
- Prior art keywords
- inotropic
- treating
- treatment
- compounds
- methyl
- Prior art date
Links
- 230000000297 inotrophic effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 210000004413 cardiac myocyte Anatomy 0.000 abstract 2
- 239000004041 inotropic agent Substances 0.000 abstract 2
- WGIAKIIMCPKJQN-SWLSCSKDSA-N 3-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-1-methyl-1-[(4R)-1,3,3-trimethylpiperidin-4-yl]urea Chemical compound ClC1=C(C=CC(=C1Cl)OC)[C@H](C)NC(=O)N([C@H]1C(CN(CC1)C)(C)C)C WGIAKIIMCPKJQN-SWLSCSKDSA-N 0.000 abstract 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000001871 Tachycardia Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 abstract 1
- 230000006794 tachycardia Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
método para tratar uma condição que requer tratamento inotrópico. a invenção refere-se ao uso de compostos representados pela fórmula (i) como agentes inotrópicos. os compostos de fórmula (i), que incluem, como preferido, 1-[(1s)-1-(2,3-dicloro-4-metoxifenil)etil]-3-metil-3-[(4r)-1-metil-3,3-dimetil-4-piperidil]-ureia e seu sal cloridrato, são aqui relatados como tendo uma atividade inotrópica significativa em cardiomiócitos de modelos animais de insuficiência cardíaca normal e induzida por infarto do miocárdio, o que os torna úteis para tratar pacientes cardiovasculares que deles necessitam. diferentemente dos agentes inotrópicos conhecidos, os presentes compostos são eficazes na contratilidade de cardiomiócitos sem influenciar a mobilização de cálcio. consequentemente, eles são vantajosamente isentos de efeitos adversos causados por concentrações de cálcio aumentadas, tais como demanda de oxigênio aumentada, taquicardia, arritmia, isquemia etc. globalmente, é assim disponibilizado um novo tratamento inotrópico seguro e eficaz.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21177292 | 2021-06-02 | ||
PCT/EP2022/065013 WO2022253941A1 (en) | 2021-06-02 | 2022-06-02 | Piperidine urea derivatives for use as inotropic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023025327A2 true BR112023025327A2 (pt) | 2024-02-27 |
Family
ID=76250149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023025327A BR112023025327A2 (pt) | 2021-06-02 | 2022-06-02 | Método para tratar uma condição que requer tratamento inotrópico |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP4346820A1 (pt) |
JP (1) | JP2024520755A (pt) |
KR (1) | KR20240016351A (pt) |
CN (1) | CN117412750A (pt) |
AU (1) | AU2022287225A1 (pt) |
BR (1) | BR112023025327A2 (pt) |
CA (1) | CA3221574A1 (pt) |
IL (1) | IL308971A (pt) |
TW (1) | TW202313021A (pt) |
WO (1) | WO2022253941A1 (pt) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012113103A1 (en) | 2011-02-25 | 2012-08-30 | Helsinn Healthcare S.A. | Asymmetric ureas and medical uses thereof |
TWI690512B (zh) | 2014-03-07 | 2020-04-11 | 瑞士商赫爾辛保健股份有限公司 | 對位取代的不對稱脲及其醫療用途 |
EP3542799A1 (en) | 2018-03-22 | 2019-09-25 | Helsinn Healthcare SA | New centrally-active ghrelin agonist and medical uses thereof |
-
2022
- 2022-06-02 EP EP22731623.9A patent/EP4346820A1/en active Pending
- 2022-06-02 TW TW111120680A patent/TW202313021A/zh unknown
- 2022-06-02 IL IL308971A patent/IL308971A/en unknown
- 2022-06-02 CA CA3221574A patent/CA3221574A1/en active Pending
- 2022-06-02 BR BR112023025327A patent/BR112023025327A2/pt unknown
- 2022-06-02 AU AU2022287225A patent/AU2022287225A1/en active Pending
- 2022-06-02 JP JP2023575394A patent/JP2024520755A/ja active Pending
- 2022-06-02 KR KR1020237045376A patent/KR20240016351A/ko unknown
- 2022-06-02 CN CN202280039434.5A patent/CN117412750A/zh active Pending
- 2022-06-02 WO PCT/EP2022/065013 patent/WO2022253941A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
IL308971A (en) | 2024-01-01 |
EP4346820A1 (en) | 2024-04-10 |
CN117412750A (zh) | 2024-01-16 |
JP2024520755A (ja) | 2024-05-24 |
WO2022253941A1 (en) | 2022-12-08 |
TW202313021A (zh) | 2023-04-01 |
KR20240016351A (ko) | 2024-02-06 |
AU2022287225A1 (en) | 2023-11-30 |
CA3221574A1 (en) | 2022-12-08 |
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