BR112023023708A2 - Formulação contendo derivado de di-hidropiridazino-3,5-diona - Google Patents

Formulação contendo derivado de di-hidropiridazino-3,5-diona

Info

Publication number
BR112023023708A2
BR112023023708A2 BR112023023708A BR112023023708A BR112023023708A2 BR 112023023708 A2 BR112023023708 A2 BR 112023023708A2 BR 112023023708 A BR112023023708 A BR 112023023708A BR 112023023708 A BR112023023708 A BR 112023023708A BR 112023023708 A2 BR112023023708 A2 BR 112023023708A2
Authority
BR
Brazil
Prior art keywords
formulation containing
methyl
dione derivative
hydropyranzino
trifluoromethyl
Prior art date
Application number
BR112023023708A
Other languages
English (en)
Inventor
Hiromasa Uchiyama
Kenichi Sakai
Mayumi Yoshikawa
Ryusuke Takano
Shigemori Natsumoto
Tomoyuki Minoda
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BR112023023708A2 publication Critical patent/BR112023023708A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

formulação contendo derivado de di-hidropiridazino-3,5-diona. a presente invenção refere-se a uma composição farmacêutica que possui excelente propriedade de dissolução e uniformidade de conteúdo e um método de produção dessa pela mistura de um p-toluenosulfonato de 7-[[2,3-difluor-4-[2-[2-metoxietil(metil)amino]etóxi]fenil] metil]-10-hidróxi-6-metil-8-oxo-n-[4-(trifluormetil)-2-[6-(trifluormetil)pirimidin-4-il]fenil]-6,7-diazaspiro[4,5]deca-9-eno-9-carboxamida com aditivos específicos e formulando a mistura.
BR112023023708A 2021-06-08 2022-06-08 Formulação contendo derivado de di-hidropiridazino-3,5-diona BR112023023708A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021096206 2021-06-08
PCT/JP2022/023076 WO2022260064A1 (ja) 2021-06-08 2022-06-08 ジヒドロピリダジン－３，５－ジオン誘導体を含有する製剤

Publications (1)

Publication Number Publication Date
BR112023023708A2 true BR112023023708A2 (pt) 2024-01-30

Family

ID=84426023

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023023708A BR112023023708A2 (pt) 2021-06-08 2022-06-08 Formulação contendo derivado de di-hidropiridazino-3,5-diona

Country Status (10)

Country Link
EP (1) EP4353233A1 (pt)
JP (1) JPWO2022260064A1 (pt)
KR (1) KR20240018523A (pt)
CN (1) CN117460511A (pt)
AU (1) AU2022288895A1 (pt)
BR (1) BR112023023708A2 (pt)
CA (1) CA3221186A1 (pt)
IL (1) IL309056A (pt)
TW (1) TW202317118A (pt)
WO (1) WO2022260064A1 (pt)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2539722T3 (es) 2010-04-28 2015-07-03 Astellas Pharma Inc. Compuesto de tetrahidrobenzotiofeno
EP2591354B1 (en) 2010-07-07 2016-09-07 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
AU2012329913A1 (en) 2011-10-27 2014-05-22 Astellas Pharma Inc. Aminoalkyl-substituted N-thienyl benzamide derivative
WO2014003153A1 (ja) 2012-06-28 2014-01-03 協和発酵キリン株式会社 置換アミド化合物
CA2901868C (en) 2013-03-13 2022-05-03 Chugai Seiyaku Kabushiki Kaisha Dihydropyridazine-3,5-dione derivative
CN112494492B (zh) 2014-08-18 2023-08-25 阿尔科姆斯制药爱尔兰有限公司 阿立哌唑前体药物组合物
AU2015316425B2 (en) 2014-09-12 2019-11-21 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical containing sodium-dependent phosphate transporter inhibitor
AU2017312783B2 (en) 2016-08-15 2020-02-06 Eli Lilly And Company Condensed thiophene derivatives useful as NaPi-IIb inhibitors

Also Published As

Publication number Publication date
TW202317118A (zh) 2023-05-01
CA3221186A1 (en) 2022-12-15
WO2022260064A1 (ja) 2022-12-15
CN117460511A (zh) 2024-01-26
JPWO2022260064A1 (pt) 2022-12-15
EP4353233A1 (en) 2024-04-17
KR20240018523A (ko) 2024-02-13
IL309056A (en) 2024-02-01
AU2022288895A1 (en) 2024-01-18

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