BR112023021916A2 - Formas em estado sólido de (s)-n-(3-(2-(((r)-1- hidroxipropan-2-il)amino)-6-morfolinopiridin-4-il)-4- metilfenil)-3-(2,2,2-trifluoretil)pirrolidina-1-carboxamida e sais desta - Google Patents
Formas em estado sólido de (s)-n-(3-(2-(((r)-1- hidroxipropan-2-il)amino)-6-morfolinopiridin-4-il)-4- metilfenil)-3-(2,2,2-trifluoretil)pirrolidina-1-carboxamida e sais destaInfo
- Publication number
- BR112023021916A2 BR112023021916A2 BR112023021916A BR112023021916A BR112023021916A2 BR 112023021916 A2 BR112023021916 A2 BR 112023021916A2 BR 112023021916 A BR112023021916 A BR 112023021916A BR 112023021916 A BR112023021916 A BR 112023021916A BR 112023021916 A2 BR112023021916 A2 BR 112023021916A2
- Authority
- BR
- Brazil
- Prior art keywords
- solid state
- morpholinopyridin
- hydroxypropan
- carboxamide
- pyrrolidine
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 4
- LCDCPQHFCOBUEF-UHFFFAOYSA-N pyrrolidine-1-carboxamide Chemical compound NC(=O)N1CCCC1 LCDCPQHFCOBUEF-UHFFFAOYSA-N 0.000 title 1
- GZMYLSJUNSCMTD-MOPGFXCFSA-N OC[C@@H](C)NC1=NC(=CC(=C1)C=1C=C(C=CC=1C)NC(=O)N1C[C@@H](CC1)CC(F)(F)F)N1CCOCC1 Chemical compound OC[C@@H](C)NC1=NC(=CC(=C1)C=1C=C(C=CC=1C)NC(=O)N1C[C@@H](CC1)CC(F)(F)F)N1CCOCC1 GZMYLSJUNSCMTD-MOPGFXCFSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
formas em estado sólido de (s)-n-(3-(2-(((r)-1- hidroxipropan-2-il)amino)-6-morfolinopiridin-4-il)-4- metilfenil)-3-(2,2,2-trifluoretil)pirrolidina-1-carboxamida e sais desta. a presente divulgação refere-se a formas de estado sólido de (s)-n-(3-(2-(((r)-1-hidroxipropan-2-il)amino)-6-morfolinopiridin-4-il)-4-metilfenil )-3-(2,2,2-trifluoroetil)pirrolidina-1-carboxamida e seus sais. tais formas no estado sólido são úteis na preparação de composições farmacêuticas e formas farmacêuticas para o tratamento de doenças.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163178752P | 2021-04-23 | 2021-04-23 | |
PCT/US2022/025815 WO2022226221A1 (en) | 2021-04-23 | 2022-04-21 | Solid state forms of (s)-n-(3-(2-(((r)-1-hydroxypropan-2-yl)amino)-6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and salts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023021916A2 true BR112023021916A2 (pt) | 2023-12-19 |
Family
ID=83723159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023021916A BR112023021916A2 (pt) | 2021-04-23 | 2022-04-21 | Formas em estado sólido de (s)-n-(3-(2-(((r)-1- hidroxipropan-2-il)amino)-6-morfolinopiridin-4-il)-4- metilfenil)-3-(2,2,2-trifluoretil)pirrolidina-1-carboxamida e sais desta |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP4326255A1 (pt) |
JP (1) | JP2024517431A (pt) |
KR (1) | KR20240000540A (pt) |
CN (1) | CN117529313A (pt) |
AU (1) | AU2022261159A1 (pt) |
BR (1) | BR112023021916A2 (pt) |
CA (1) | CA3216258A1 (pt) |
IL (1) | IL307910A (pt) |
TW (1) | TW202309018A (pt) |
WO (1) | WO2022226221A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022081469A1 (en) | 2020-10-12 | 2022-04-21 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
CA3216104A1 (en) | 2021-04-23 | 2022-10-27 | Aleksandra Franovic | Treatment of cancer with a raf inhibitor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9242969B2 (en) * | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
UY36294A (es) * | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
CN114072148A (zh) * | 2019-05-03 | 2022-02-18 | 金耐特生物制药公司 | Raf激酶的抑制剂 |
EP4048259A4 (en) * | 2019-10-24 | 2023-08-02 | Kinnate Biopharma Inc. | RAF KINASE INHIBITORS |
-
2022
- 2022-04-21 AU AU2022261159A patent/AU2022261159A1/en active Pending
- 2022-04-21 KR KR1020237039724A patent/KR20240000540A/ko unknown
- 2022-04-21 WO PCT/US2022/025815 patent/WO2022226221A1/en active Application Filing
- 2022-04-21 IL IL307910A patent/IL307910A/en unknown
- 2022-04-21 CN CN202280044060.6A patent/CN117529313A/zh active Pending
- 2022-04-21 JP JP2023565206A patent/JP2024517431A/ja active Pending
- 2022-04-21 BR BR112023021916A patent/BR112023021916A2/pt unknown
- 2022-04-21 EP EP22792520.3A patent/EP4326255A1/en active Pending
- 2022-04-21 CA CA3216258A patent/CA3216258A1/en active Pending
- 2022-04-22 TW TW111115523A patent/TW202309018A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
IL307910A (en) | 2023-12-01 |
JP2024517431A (ja) | 2024-04-22 |
WO2022226221A1 (en) | 2022-10-27 |
EP4326255A1 (en) | 2024-02-28 |
TW202309018A (zh) | 2023-03-01 |
AU2022261159A1 (en) | 2023-11-23 |
CA3216258A1 (en) | 2022-10-27 |
KR20240000540A (ko) | 2024-01-02 |
CN117529313A (zh) | 2024-02-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112023021916A2 (pt) | Formas em estado sólido de (s)-n-(3-(2-(((r)-1- hidroxipropan-2-il)amino)-6-morfolinopiridin-4-il)-4- metilfenil)-3-(2,2,2-trifluoretil)pirrolidina-1-carboxamida e sais desta | |
BRPI0513864A (pt) | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, sua utilização e método para o tratamento e/ou profilaxia de enfermidades | |
BR0009042A (pt) | Composto, uso do mesmo, processo para prepararum composto, composição farmacêutica, e, métodospara tratar uma doença em um animal em que aatividade de cisteìna protease contribui para apatologia e/ou sintomatologia da doença, e paratratar uma doença em um animal em que a atividadede catepsina s contribui para a patologia e/ousintomatologia da doença | |
BRPI0513717A (pt) | derivados de piridina | |
BR112021022335A2 (pt) | Formas cristalinas de n-(3-(2-(2-hidroxietoxi)-6-morfolinopiridin-4-il)-4-metilfenil)-2 (trifluorome-til)isonicotinamida como inibidores raf para o tratamento de câncer | |
BRPI0407139A (pt) | Compostos de amida substituìda por tri(ciclo) | |
NO20051966L (no) | Nye pyrimidinamidderivater og anvendelse derav | |
BR0209821A (pt) | Compostos, processo para a manufatura desses compostos, composições farmacêuticas que compreendem os mesmos, processo para o tratamento e/ou profilaxia de enfermidades e utilização dos compostos | |
BRPI0514372A (pt) | inibidores de tiazol de frutose 1, 6-bisfosfatase | |
BR0012804A (pt) | Derivados de amina e amida como ligandos para o receptor de neuropeptìdeo y y5 útil no tratamento da obesidade e outros distúrbios | |
BRPI0409624A (pt) | 2-hidróxi-3-diaminoalcanos de benzamida | |
AR045317A1 (es) | Forma cristalina de agonista dl receptor adrenergico b2 | |
GT200200272A (es) | Formas de sal e-2-metoxi-n-(3-{4-[3-metil-4-(6-metilpiridin-3-iloxi) fenilamino] quinazolin-6-il} alil)acetamidayprocedimiento para la produccion | |
AR053169A1 (es) | Metabolitos de n-2 (cloro-6-metilfenil)-2-[[6-[4-(2-hidroxietil)-1-piperazinil) -2-metil -4-pi rimidinil] amino]-5-tiazol carboxamidas | |
BR0209518A (pt) | Novos derivados arilheteroalquilamina | |
BR0308814A (pt) | Aminoácidos com afinidade para a proteìna-alfa2gama | |
BRPI0409182A (pt) | derivados de oxima e seu uso como agentes farmaceuticamente ativos | |
BRPI0415953B8 (pt) | formulação de dosagem de liberação controlada e conjunto de formas de dosagem de liberação controlada | |
MX2021015853A (es) | Analogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2-(trifluor-met il)pirimidin-5-il]etil}benzamida. | |
BR112022007488A2 (pt) | Forma cristalina de base livre de um receptor c5a de componente do complemento | |
CY1109975T1 (el) | Παρα-αλκυλ-υποκατεστημενα αμιδια ν-(4-υδροξυ-3-μεθοξυ-βενζυλο) κιναμμωμικου οξεος και η χρησιμοποιηση τους για την παρασκευη φαρμακων | |
NI200900161A (es) | Sales de adición de ácido, hidratos y polimorfos de la etil - amida del ácido 5 - (2,4 -dihidroxi -5- isopropil - fenil) -4- (4-morfolin-4-il-metil-fenil)-isoxazol-3-carboxílico, y formulaciones que comprenden estas formas. | |
CO2023010010A2 (es) | Composición farmacéutica que comprende un derivado de difenilpirazina | |
BRPI0414781A (pt) | aminoácidos com afinidade para a proteìna (alfa)2(delta) | |
UY37987A (es) | Procedimiento para la preparación de (3s)-3-(4-cloro-3-{[(2s,3r)-2-(4-clorofenil)-4,4,4-trifluor-3- metilbutanoil]amino}fenil)-3-ácido ciclopropilpropanoico y su forma cristalina para uso como principio activo farmacéutico. |