BR112023021215A2 - Compostos de alquinilfenilbenzamida, usos dos mesmos e composição farmacêutica compreendendo os referidos compostos - Google Patents
Compostos de alquinilfenilbenzamida, usos dos mesmos e composição farmacêutica compreendendo os referidos compostosInfo
- Publication number
- BR112023021215A2 BR112023021215A2 BR112023021215A BR112023021215A BR112023021215A2 BR 112023021215 A2 BR112023021215 A2 BR 112023021215A2 BR 112023021215 A BR112023021215 A BR 112023021215A BR 112023021215 A BR112023021215 A BR 112023021215A BR 112023021215 A2 BR112023021215 A2 BR 112023021215A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- alkynylphenylbenzamide
- pharmaceutical composition
- compound
- protein kinase
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000009545 invasion Effects 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000003909 protein kinase inhibitor Substances 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Abstract
compostos de alquinilfenilbenzamida, usos dos mesmos e composição farmacêutica compreendendo os referidos compostos. a presente invenção está relacionada a um composto alquinilfenilbenzamida e ao uso do mesmo. o composto alquinilfenilbenzamida da presente invenção tem uma estrutura conforme apresentada na fórmula (i), pode ser usado como um inibidor de proteína quinase, pode inibir efetivamente a atividade de uma proteína quinase trk e pode inibir a proliferação, migração e invasão de várias células tumorais, e também possui características de boa farmacocinética e baixa toxicidade. (i)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110395086 | 2021-04-13 | ||
PCT/CN2021/117495 WO2022217821A1 (zh) | 2021-04-13 | 2021-09-09 | 炔苯基苯酰胺类化合物及其应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023021215A2 true BR112023021215A2 (pt) | 2023-12-19 |
Family
ID=78958920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023021215A BR112023021215A2 (pt) | 2021-04-13 | 2021-09-09 | Compostos de alquinilfenilbenzamida, usos dos mesmos e composição farmacêutica compreendendo os referidos compostos |
Country Status (8)
Country | Link |
---|---|
US (1) | US11834454B2 (pt) |
EP (1) | EP4324833A1 (pt) |
JP (1) | JP2024514015A (pt) |
KR (1) | KR20230170938A (pt) |
CN (1) | CN113831344B (pt) |
AU (1) | AU2021440841A1 (pt) |
BR (1) | BR112023021215A2 (pt) |
WO (1) | WO2022217821A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024027792A1 (en) * | 2022-08-05 | 2024-02-08 | Shenzhen Newdel Biotech Co., Ltd. | Protein kinase degrading agent, medicament and use |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101436303B1 (ko) * | 2005-12-23 | 2014-09-02 | 어리어드 파마슈티칼스, 인코포레이티드 | 비시클릭 헤테로아릴 화합물 |
CN103596568A (zh) * | 2011-04-07 | 2014-02-19 | 阿里亚德医药股份有限公司 | 治疗帕金森病的方法以及组合物 |
US8859553B2 (en) * | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
WO2015085972A1 (en) * | 2013-12-09 | 2015-06-18 | Zentiva, K.S. | NOVEL SALTS OF 3-(2-IMIDAZO[1,2-b]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-[4-[(4-METHYL- 1-PIPERAZINYL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL] BENZAMIDE |
GB2522226A (en) * | 2014-01-17 | 2015-07-22 | Agency Science Tech & Res | Heteroaryl alkyne derivatives and uses thereof |
WO2018089736A1 (en) * | 2016-11-10 | 2018-05-17 | Dana-Farber Cancer Institute, Inc. | Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use |
-
2021
- 2021-09-09 AU AU2021440841A patent/AU2021440841A1/en active Pending
- 2021-09-09 KR KR1020237038624A patent/KR20230170938A/ko unknown
- 2021-09-09 CN CN202111057771.0A patent/CN113831344B/zh active Active
- 2021-09-09 EP EP21936693.7A patent/EP4324833A1/en active Pending
- 2021-09-09 BR BR112023021215A patent/BR112023021215A2/pt unknown
- 2021-09-09 WO PCT/CN2021/117495 patent/WO2022217821A1/zh active Application Filing
- 2021-09-09 JP JP2023564002A patent/JP2024514015A/ja active Pending
-
2022
- 2022-09-20 US US17/948,236 patent/US11834454B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20230170938A (ko) | 2023-12-19 |
US11834454B2 (en) | 2023-12-05 |
AU2021440841A1 (en) | 2023-10-19 |
CN113831344A (zh) | 2021-12-24 |
JP2024514015A (ja) | 2024-03-27 |
WO2022217821A1 (zh) | 2022-10-20 |
CN113831344B (zh) | 2022-09-16 |
EP4324833A1 (en) | 2024-02-21 |
US20230046126A1 (en) | 2023-02-16 |
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