BR112023018816A2 - Antagonista do receptor de melanocortina subtipo-2 (mc2r) para o tratamento de doença - Google Patents

Antagonista do receptor de melanocortina subtipo-2 (mc2r) para o tratamento de doença

Info

Publication number
BR112023018816A2
BR112023018816A2 BR112023018816A BR112023018816A BR112023018816A2 BR 112023018816 A2 BR112023018816 A2 BR 112023018816A2 BR 112023018816 A BR112023018816 A BR 112023018816A BR 112023018816 A BR112023018816 A BR 112023018816A BR 112023018816 A2 BR112023018816 A2 BR 112023018816A2
Authority
BR
Brazil
Prior art keywords
disease
mc2r
antagonist
treatment
receptor subtype
Prior art date
Application number
BR112023018816A
Other languages
English (en)
Portuguese (pt)
Inventor
S Krasner Alan
Christine Ferrara-Cook
Original Assignee
Crinetics Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crinetics Pharmaceuticals Inc filed Critical Crinetics Pharmaceuticals Inc
Publication of BR112023018816A2 publication Critical patent/BR112023018816A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112023018816A 2021-03-19 2022-03-16 Antagonista do receptor de melanocortina subtipo-2 (mc2r) para o tratamento de doença BR112023018816A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163163310P 2021-03-19 2021-03-19
US202263298571P 2022-01-11 2022-01-11
PCT/US2022/020543 WO2022197798A1 (en) 2021-03-19 2022-03-16 Melanocortin subtype-2 receptor (mc2r) antagonist for the treatment of disease

Publications (1)

Publication Number Publication Date
BR112023018816A2 true BR112023018816A2 (pt) 2023-10-31

Family

ID=83321094

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023018816A BR112023018816A2 (pt) 2021-03-19 2022-03-16 Antagonista do receptor de melanocortina subtipo-2 (mc2r) para o tratamento de doença

Country Status (10)

Country Link
US (2) US12280046B2 (https=)
EP (1) EP4308553A4 (https=)
JP (2) JP2024510260A (https=)
KR (1) KR20230159443A (https=)
AU (1) AU2022240609A1 (https=)
BR (1) BR112023018816A2 (https=)
CA (1) CA3211644A1 (https=)
IL (1) IL305952A (https=)
MX (1) MX2023010897A (https=)
WO (1) WO2022197798A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019280689B2 (en) 2018-06-05 2024-09-05 Crinetics Pharmaceuticals, Inc. Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof
AU2022240609A1 (en) 2021-03-19 2023-09-28 Crinetics Pharmaceuticals, Inc. Melanocortin subtype-2 receptor (mc2r) antagonist for the treatment of disease
CN120344523A (zh) * 2022-12-16 2025-07-18 克林提克斯医药股份有限公司 结晶黑皮质素亚型-2受体(mc2r)拮抗剂
WO2024242979A1 (en) * 2023-05-19 2024-11-28 Crinetics Pharmaceuticals, Inc. Compositions and methods for the treatment of congenital adrenal hyperplasia

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WO1999064002A1 (en) 1998-06-11 1999-12-16 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
CA2377369A1 (en) 1999-06-04 2000-12-14 Merck & Co., Inc. Substituted piperidines as melanocortin-4 receptor agonists
US6890940B2 (en) 2001-06-29 2005-05-10 Kowa Co., Ltd. Bis(2-aryl-5-pyridyl) derivatives
US7115607B2 (en) 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
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EP1460073A1 (en) 2003-03-20 2004-09-22 MyoContract Ltd. Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators
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CN1874777B (zh) 2003-09-09 2012-07-04 弗·哈夫曼-拉罗切有限公司 作为甘氨酸摄取抑制剂用于治疗精神病的1-(2-氨基-苯甲酰基)-哌嗪衍生物
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AU2022240609A1 (en) 2021-03-19 2023-09-28 Crinetics Pharmaceuticals, Inc. Melanocortin subtype-2 receptor (mc2r) antagonist for the treatment of disease
WO2023163945A1 (en) 2022-02-23 2023-08-31 Crinetics Pharmaceuticals, Inc. Treatment of congenital adrenal hyperplasia and polycystic ovary syndrome
CN120344523A (zh) 2022-12-16 2025-07-18 克林提克斯医药股份有限公司 结晶黑皮质素亚型-2受体(mc2r)拮抗剂

Also Published As

Publication number Publication date
US20250367190A1 (en) 2025-12-04
WO2022197798A1 (en) 2022-09-22
JP2026009936A (ja) 2026-01-21
EP4308553A1 (en) 2024-01-24
US20220313691A1 (en) 2022-10-06
IL305952A (en) 2023-11-01
CA3211644A1 (en) 2022-09-22
TW202302108A (zh) 2023-01-16
KR20230159443A (ko) 2023-11-21
MX2023010897A (es) 2023-09-27
AU2022240609A1 (en) 2023-09-28
US12280046B2 (en) 2025-04-22
EP4308553A4 (en) 2025-01-22
JP2024510260A (ja) 2024-03-06

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Legal Events

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Owner name: CRINETICS PHARMACEUTICALS, INC. (US)