BR112023003517A2 - Moduladores da proteína proto-oncogênica da família myc - Google Patents
Moduladores da proteína proto-oncogênica da família mycInfo
- Publication number
- BR112023003517A2 BR112023003517A2 BR112023003517A BR112023003517A BR112023003517A2 BR 112023003517 A2 BR112023003517 A2 BR 112023003517A2 BR 112023003517 A BR112023003517 A BR 112023003517A BR 112023003517 A BR112023003517 A BR 112023003517A BR 112023003517 A2 BR112023003517 A2 BR 112023003517A2
- Authority
- BR
- Brazil
- Prior art keywords
- myc family
- proto
- oncogen
- protein modulators
- compositions
- Prior art date
Links
- 108091057508 Myc family Proteins 0.000 title abstract 4
- 229940076155 protein modulator Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000052575 Proto-Oncogene Human genes 0.000 abstract 1
- 108700020978 Proto-Oncogene Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063070762P | 2020-08-26 | 2020-08-26 | |
| US202063070753P | 2020-08-26 | 2020-08-26 | |
| PCT/US2021/047489 WO2022046861A1 (en) | 2020-08-26 | 2021-08-25 | Modulators of myc family proto-oncogene protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023003517A2 true BR112023003517A2 (pt) | 2023-05-09 |
Family
ID=77775028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023003517A BR112023003517A2 (pt) | 2020-08-26 | 2021-08-25 | Moduladores da proteína proto-oncogênica da família myc |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230322722A1 (https=) |
| EP (1) | EP4204411A1 (https=) |
| JP (1) | JP2023543670A (https=) |
| KR (1) | KR20230074733A (https=) |
| AU (1) | AU2021333760A1 (https=) |
| BR (1) | BR112023003517A2 (https=) |
| CA (1) | CA3190539A1 (https=) |
| IL (1) | IL300906A (https=) |
| MX (1) | MX2023002378A (https=) |
| TW (1) | TW202227411A (https=) |
| WO (1) | WO2022046861A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202325272A (zh) * | 2021-10-29 | 2023-07-01 | 日商田邊三菱製藥股份有限公司 | 新穎之螺環化合物 |
| US20250177393A1 (en) * | 2022-02-25 | 2025-06-05 | Nalo Therapeutics | Modulators of myc family proto-oncogene protein |
| WO2025043063A1 (en) * | 2023-08-24 | 2025-02-27 | Nalo Therapeutics, Inc. | Modulators of myc family proto-oncogene protein |
| WO2025043065A1 (en) * | 2023-08-24 | 2025-02-27 | Nalo Therapeutics, Inc. | Modulators of myc family proto-oncogene protein |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003286711A1 (en) * | 2002-10-25 | 2004-05-13 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| JP2008525422A (ja) * | 2004-12-23 | 2008-07-17 | ファイザー・プロダクツ・インク | 抗癌剤として有用な複素芳香族誘導体 |
| ATE519759T1 (de) * | 2004-12-30 | 2011-08-15 | Exelixis Inc | Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren |
| US20070179125A1 (en) * | 2005-11-16 | 2007-08-02 | Damien Fraysse | Aminopyrimidines useful as kinase inhibitors |
| US8101621B2 (en) * | 2006-04-27 | 2012-01-24 | Msd K.K. | Aminopyridine derivatives having aurora a selective inhibitory action |
| WO2010144522A1 (en) * | 2009-06-09 | 2010-12-16 | Abraxis Bioscience, Llc | Ureidophenyl substituted triazine derivatives and their therapeutical applications |
| CN103781779B (zh) * | 2011-09-05 | 2016-06-08 | 浙江海正药业股份有限公司 | 具有蛋白激酶抑制活性的4-取代-(3-取代-1h-吡唑-5-氨基)-嘧啶衍生物及其用途 |
| SG11202001706RA (en) * | 2017-10-27 | 2020-03-30 | Theravance Biopharma R&D Ip Llc | Pyrimidine compound as jak kinase inhibitor |
| US11584737B2 (en) * | 2018-03-29 | 2023-02-21 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2020108516A1 (zh) * | 2018-11-27 | 2020-06-04 | 江苏豪森药业集团有限公司 | 含氮杂芳类衍生物调节剂、其制备方法和应用 |
| CN113710663A (zh) * | 2019-02-19 | 2021-11-26 | 纳罗医疗公司 | Myc家族原癌基因蛋白的调节剂 |
-
2021
- 2021-08-25 CA CA3190539A patent/CA3190539A1/en active Pending
- 2021-08-25 KR KR1020237010219A patent/KR20230074733A/ko not_active Withdrawn
- 2021-08-25 JP JP2023513890A patent/JP2023543670A/ja active Pending
- 2021-08-25 EP EP21770396.6A patent/EP4204411A1/en not_active Withdrawn
- 2021-08-25 BR BR112023003517A patent/BR112023003517A2/pt not_active Application Discontinuation
- 2021-08-25 MX MX2023002378A patent/MX2023002378A/es unknown
- 2021-08-25 IL IL300906A patent/IL300906A/en unknown
- 2021-08-25 WO PCT/US2021/047489 patent/WO2022046861A1/en not_active Ceased
- 2021-08-25 AU AU2021333760A patent/AU2021333760A1/en not_active Abandoned
- 2021-08-25 US US18/023,298 patent/US20230322722A1/en active Pending
- 2021-08-26 TW TW110131640A patent/TW202227411A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230074733A (ko) | 2023-05-31 |
| MX2023002378A (es) | 2023-05-22 |
| IL300906A (en) | 2023-04-01 |
| AU2021333760A1 (en) | 2023-04-06 |
| CA3190539A1 (en) | 2022-03-03 |
| US20230322722A1 (en) | 2023-10-12 |
| WO2022046861A1 (en) | 2022-03-03 |
| JP2023543670A (ja) | 2023-10-18 |
| TW202227411A (zh) | 2022-07-16 |
| EP4204411A1 (en) | 2023-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |