BR112023003457A2 - Uso de tiazolidas contra coronavírus - Google Patents
Uso de tiazolidas contra coronavírusInfo
- Publication number
- BR112023003457A2 BR112023003457A2 BR112023003457A BR112023003457A BR112023003457A2 BR 112023003457 A2 BR112023003457 A2 BR 112023003457A2 BR 112023003457 A BR112023003457 A BR 112023003457A BR 112023003457 A BR112023003457 A BR 112023003457A BR 112023003457 A2 BR112023003457 A2 BR 112023003457A2
- Authority
- BR
- Brazil
- Prior art keywords
- thiazolids
- against coronavirus
- coronavirus
- viruses belonging
- orthocoronavirinae
- Prior art date
Links
- 241000711573 Coronaviridae Species 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- FDTZUTSGGSRHQF-UHFFFAOYSA-N Desacetyl-nitazoxanide Chemical compound OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 FDTZUTSGGSRHQF-UHFFFAOYSA-N 0.000 abstract 1
- YQNQNVDNTFHQSW-UHFFFAOYSA-N acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 YQNQNVDNTFHQSW-UHFFFAOYSA-N 0.000 abstract 1
- 229960002480 nitazoxanide Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
USO DE TIAZOLIDAS CONTRA CORONAVÍRUS. É revelado o uso de tiazolidas, tais como nitazoxanida e/ou tizoxanida, contra vírus pertencendo à família Coronaviridae, tal como vírus pertencendo à subfamília Orthocoronavirinae.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063069313P | 2020-08-24 | 2020-08-24 | |
| PCT/US2021/047128 WO2022046622A1 (en) | 2020-08-24 | 2021-08-23 | Use of thiazolides against coronaviruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023003457A2 true BR112023003457A2 (pt) | 2023-05-02 |
Family
ID=77802249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023003457A BR112023003457A2 (pt) | 2020-08-24 | 2021-08-23 | Uso de tiazolidas contra coronavírus |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230330069A1 (pt) |
| EP (1) | EP4199923A1 (pt) |
| JP (1) | JP2023538136A (pt) |
| KR (1) | KR20230098780A (pt) |
| CN (1) | CN116367892A (pt) |
| AU (1) | AU2021333566A1 (pt) |
| BR (1) | BR112023003457A2 (pt) |
| CA (1) | CA3189487A1 (pt) |
| CL (1) | CL2023000523A1 (pt) |
| IL (1) | IL300801A (pt) |
| MX (1) | MX2023002208A (pt) |
| WO (1) | WO2022046622A1 (pt) |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1437800A (en) | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| MX9604483A (es) | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US5859038A (en) | 1994-09-08 | 1999-01-12 | Romark Laboratories, L.C. | Method for treatment of helicobacter pylori infections |
| US5968961A (en) | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5856348A (en) | 1994-09-08 | 1999-01-05 | Romark Laboratories, L.C. | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5965590A (en) | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5935591A (en) | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
| US20050171169A1 (en) | 2004-02-02 | 2005-08-04 | Rossignol Jean F. | Combination chemotherapy for helminth infections |
| UA90864C2 (en) | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| US20060194853A1 (en) | 2004-10-08 | 2006-08-31 | Rossignol Jean F | Alkyl benzamides |
| CA2604640A1 (en) | 2005-04-12 | 2006-10-19 | Romark Laboratories L.C. | Methods for treating diseases through interruption of protein maturation, compounds that inhibit the function of molecular chaperones such as protein disulfide isomerases or interfere with glycosylation, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
| BRPI0706379A2 (pt) | 2006-01-09 | 2011-03-22 | Romark Lab Lc | tratamento de hepatite viral |
| MX2010001358A (es) | 2007-08-03 | 2010-04-09 | Romark Lab Lc | Compuestos de tiazolida sustituidos con alquilsulfonilo. |
| LT2395840T (lt) | 2009-02-13 | 2020-07-10 | Romark Laboratories, L.C. | Nitazoksanido kontroliuojamo atpalaidavimo farmacinės kompozicijos |
| CA2940954A1 (en) | 2009-05-12 | 2010-11-18 | Romark Laboratories L.C. | Nitazoxanide and tizoxanide for the treatment of rhinovirus and rhabdovirus infections |
| BR122020003634B8 (pt) | 2009-06-26 | 2021-07-27 | Romark Laboratories Lc | uso de nitazoxanida, tizoxanida ou sal farmaceuticalmente aceitável do mesmo no tratamento de uma doença semelhante a influenza |
| WO2012058378A1 (en) | 2010-10-29 | 2012-05-03 | Romark Laboratories L.C. | Pharmaceutical compositions and methods of use of salicylanilides for treatment of hepatitis viruses |
| EP2635124A4 (en) | 2010-11-01 | 2014-04-16 | Romark Lab Lc | ALKYLSULFINYL-SUBSTITUTED THIAZOLIDE COMPOUNDS |
| US20120294831A1 (en) | 2011-05-16 | 2012-11-22 | Romark Laboratories L.C. | Use of thiazolide compounds for the prevention and treatment of viral diseases, cancer and diseases caused by intracellular infections |
| CN104169154B (zh) | 2012-03-15 | 2017-04-12 | 丰田自动车株式会社 | 车辆行驶控制装置 |
| BR112017009651A2 (pt) | 2014-11-11 | 2017-12-19 | Romark Laboratories Lc | composto, composição farmacêutica, e, método para tratamento de uma infecção por protozoário intracelular, uma infecção viral ou um câncer. |
| WO2017173056A1 (en) | 2016-03-31 | 2017-10-05 | Romark Laboratories L.C. | Thiazolide compounds for treating viral infections |
| WO2018195035A1 (en) | 2017-04-18 | 2018-10-25 | Romark Laboratories L.C. | Inhibition of protein disulfide-isomerase a3 |
| CN114599365A (zh) * | 2019-08-22 | 2022-06-07 | 内布拉斯加大学董事会 | 前药及其制剂 |
| US20230241037A1 (en) * | 2020-03-09 | 2023-08-03 | 1Globe Health Institute, Nanjing | Cross-linked medication for treatment of coronaviral infection and method of treatment |
| CN111544431A (zh) * | 2020-06-23 | 2020-08-18 | 瑞阳制药有限公司 | 硝唑尼特在制备预防及治疗间质性肺病药物中的应用 |
-
2021
- 2021-08-23 MX MX2023002208A patent/MX2023002208A/es unknown
- 2021-08-23 US US18/022,963 patent/US20230330069A1/en active Pending
- 2021-08-23 KR KR1020237008708A patent/KR20230098780A/ko unknown
- 2021-08-23 BR BR112023003457A patent/BR112023003457A2/pt unknown
- 2021-08-23 JP JP2023512716A patent/JP2023538136A/ja active Pending
- 2021-08-23 CA CA3189487A patent/CA3189487A1/en active Pending
- 2021-08-23 EP EP21772893.0A patent/EP4199923A1/en active Pending
- 2021-08-23 AU AU2021333566A patent/AU2021333566A1/en active Pending
- 2021-08-23 WO PCT/US2021/047128 patent/WO2022046622A1/en unknown
- 2021-08-23 IL IL300801A patent/IL300801A/en unknown
- 2021-08-23 CN CN202180071246.6A patent/CN116367892A/zh active Pending
-
2023
- 2023-02-22 CL CL2023000523A patent/CL2023000523A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022046622A1 (en) | 2022-03-03 |
| AU2021333566A1 (en) | 2023-03-16 |
| EP4199923A1 (en) | 2023-06-28 |
| CN116367892A (zh) | 2023-06-30 |
| CA3189487A1 (en) | 2023-03-03 |
| IL300801A (en) | 2023-04-01 |
| CL2023000523A1 (es) | 2023-10-06 |
| JP2023538136A (ja) | 2023-09-06 |
| US20230330069A1 (en) | 2023-10-19 |
| MX2023002208A (es) | 2023-05-17 |
| KR20230098780A (ko) | 2023-07-04 |
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