BR112023002134A2 - 2-((4s)-6-(4-clorofenil)-1-metil-4hbenzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida para tratamento de trombocitemia - Google Patents
2-((4s)-6-(4-clorofenil)-1-metil-4hbenzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida para tratamento de trombocitemiaInfo
- Publication number
- BR112023002134A2 BR112023002134A2 BR112023002134A BR112023002134A BR112023002134A2 BR 112023002134 A2 BR112023002134 A2 BR 112023002134A2 BR 112023002134 A BR112023002134 A BR 112023002134A BR 112023002134 A BR112023002134 A BR 112023002134A BR 112023002134 A2 BR112023002134 A2 BR 112023002134A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoxazolo
- thrombocythemia
- azepin
- acetamide
- chlorophenyl
- Prior art date
Links
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title abstract 4
- 208000005485 Thrombocytosis Diseases 0.000 title abstract 3
- GCWIQUVXWZWCLE-INIZCTEOSA-N pelabresib Chemical compound N([C@@H](CC(N)=O)C=1ON=C(C=1C1=CC=CC=C11)C)=C1C1=CC=C(Cl)C=C1 GCWIQUVXWZWCLE-INIZCTEOSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
2-((4S)-6-(4-CLOROFENIL)-1-METIL-4H-BENZO[C]ISOXAZOLO[4,5-E]AZEPIN-4-IL)ACETAMIDA PARA TRATAMENTO DE TROMBOCITEMIA. A presente invenção refere-se ao uso de 2-((4S)-6-(4-clorofenil)-l-metil -4 H-benzo [c] isoxazolo [4,5-e] azepin-4-il) acetamida, e seus sais farmaceuticamente aceitáveis, para o tratamento de trombocitemia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063060723P | 2020-08-04 | 2020-08-04 | |
| PCT/US2021/044318 WO2022031686A1 (en) | 2020-08-04 | 2021-08-03 | 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide for treating thrombocythemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023002134A2 true BR112023002134A2 (pt) | 2023-03-07 |
Family
ID=77519789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023002134A BR112023002134A2 (pt) | 2020-08-04 | 2021-08-03 | 2-((4s)-6-(4-clorofenil)-1-metil-4hbenzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida para tratamento de trombocitemia |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230302010A1 (pt) |
| EP (1) | EP4192470A1 (pt) |
| JP (1) | JP2023537715A (pt) |
| KR (1) | KR20230048042A (pt) |
| CN (1) | CN116367839A (pt) |
| AU (1) | AU2021320151A1 (pt) |
| BR (1) | BR112023002134A2 (pt) |
| CA (1) | CA3188245A1 (pt) |
| CL (1) | CL2023000362A1 (pt) |
| IL (1) | IL300337A (pt) |
| MX (1) | MX2023001552A (pt) |
| WO (1) | WO2022031686A1 (pt) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| EP3157928B1 (en) | 2014-06-20 | 2019-02-13 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| WO2020112939A1 (en) * | 2018-11-27 | 2020-06-04 | Constellation Pharmaceuticals, Inc. | Methods of treating myeloproliferative disorders |
-
2021
- 2021-08-03 CA CA3188245A patent/CA3188245A1/en active Pending
- 2021-08-03 AU AU2021320151A patent/AU2021320151A1/en active Pending
- 2021-08-03 EP EP21762216.6A patent/EP4192470A1/en active Pending
- 2021-08-03 US US18/019,634 patent/US20230302010A1/en active Pending
- 2021-08-03 JP JP2023507598A patent/JP2023537715A/ja active Pending
- 2021-08-03 CN CN202180065736.5A patent/CN116367839A/zh active Pending
- 2021-08-03 IL IL300337A patent/IL300337A/en unknown
- 2021-08-03 WO PCT/US2021/044318 patent/WO2022031686A1/en unknown
- 2021-08-03 MX MX2023001552A patent/MX2023001552A/es unknown
- 2021-08-03 BR BR112023002134A patent/BR112023002134A2/pt unknown
- 2021-08-03 KR KR1020237004712A patent/KR20230048042A/ko unknown
-
2023
- 2023-02-03 CL CL2023000362A patent/CL2023000362A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20230302010A1 (en) | 2023-09-28 |
| CL2023000362A1 (es) | 2024-01-19 |
| MX2023001552A (es) | 2023-05-03 |
| CN116367839A (zh) | 2023-06-30 |
| JP2023537715A (ja) | 2023-09-05 |
| IL300337A (en) | 2023-04-01 |
| KR20230048042A (ko) | 2023-04-10 |
| CA3188245A1 (en) | 2022-02-10 |
| EP4192470A1 (en) | 2023-06-14 |
| WO2022031686A1 (en) | 2022-02-10 |
| AU2021320151A1 (en) | 2023-02-23 |
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