BR112023001236A2 - Polimorfos de 5-aza-4'-tio-2-desoxicitidina - Google Patents
Polimorfos de 5-aza-4'-tio-2-desoxicitidinaInfo
- Publication number
- BR112023001236A2 BR112023001236A2 BR112023001236A BR112023001236A BR112023001236A2 BR 112023001236 A2 BR112023001236 A2 BR 112023001236A2 BR 112023001236 A BR112023001236 A BR 112023001236A BR 112023001236 A BR112023001236 A BR 112023001236A BR 112023001236 A2 BR112023001236 A2 BR 112023001236A2
- Authority
- BR
- Brazil
- Prior art keywords
- deoxycytidine
- aza
- thio
- polymorphs
- crystalline polymorphs
- Prior art date
Links
- 201000003793 Myelodysplastic syndrome Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000005787 hematologic cancer Diseases 0.000 abstract 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063055754P | 2020-07-23 | 2020-07-23 | |
| PCT/US2021/043021 WO2022020747A1 (en) | 2020-07-23 | 2021-07-23 | Polymorophs of 5-aza-4'-thio-2-deoxycytidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023001236A2 true BR112023001236A2 (pt) | 2023-04-04 |
Family
ID=79687860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023001236A BR112023001236A2 (pt) | 2020-07-23 | 2021-07-23 | Polimorfos de 5-aza-4'-tio-2-desoxicitidina |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11447472B2 (https=) |
| EP (1) | EP4185583A4 (https=) |
| JP (1) | JP7679452B2 (https=) |
| KR (1) | KR102866823B1 (https=) |
| CN (1) | CN115989229A (https=) |
| AU (1) | AU2021314329A1 (https=) |
| BR (1) | BR112023001236A2 (https=) |
| CA (1) | CA3186696A1 (https=) |
| MX (1) | MX2023000979A (https=) |
| WO (1) | WO2022020747A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230123277A1 (en) * | 2021-10-15 | 2023-04-20 | Akirabio, Inc. | Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease and thalassemia |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020322A (en) | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US5591722A (en) | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| US20060014949A1 (en) * | 2004-07-13 | 2006-01-19 | Supergen Inc. | Compositions and formulations of decitabine polymorphs and methods of use thereof |
| CN103951583B (zh) * | 2006-12-06 | 2016-01-06 | 科内图斯医药公司 | 一种抑制剂的结晶形式 |
| PL3692983T3 (pl) | 2008-05-15 | 2021-12-27 | Celgene Corporation | Doustne formulacje analogów cytydyny i sposoby ich zastosowania |
| WO2011109012A1 (en) | 2010-03-02 | 2011-09-09 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| US20110218170A1 (en) | 2010-03-02 | 2011-09-08 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| SG11201610551TA (en) | 2014-07-14 | 2017-01-27 | Gilead Sciences Inc | Combinations for treating cancers |
| US20160312261A1 (en) | 2015-04-24 | 2016-10-27 | Plasmia Biotech, S.L. | Enzymatic production of cytosinic nucleoside analogues |
| EP3527226A4 (en) | 2016-10-17 | 2020-06-17 | Daiichi Sankyo Company, Limited | COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR |
| EP3746452B1 (en) * | 2018-02-01 | 2023-09-13 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides |
| WO2019204637A1 (en) * | 2018-04-19 | 2019-10-24 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
-
2021
- 2021-07-23 CA CA3186696A patent/CA3186696A1/en active Pending
- 2021-07-23 BR BR112023001236A patent/BR112023001236A2/pt unknown
- 2021-07-23 JP JP2023504527A patent/JP7679452B2/ja active Active
- 2021-07-23 KR KR1020237006092A patent/KR102866823B1/ko active Active
- 2021-07-23 MX MX2023000979A patent/MX2023000979A/es unknown
- 2021-07-23 CN CN202180052138.4A patent/CN115989229A/zh active Pending
- 2021-07-23 WO PCT/US2021/043021 patent/WO2022020747A1/en not_active Ceased
- 2021-07-23 AU AU2021314329A patent/AU2021314329A1/en active Pending
- 2021-07-23 EP EP21845710.9A patent/EP4185583A4/en active Pending
- 2021-07-23 US US17/384,345 patent/US11447472B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023000979A (es) | 2023-04-20 |
| JP7679452B2 (ja) | 2025-05-19 |
| EP4185583A4 (en) | 2024-10-30 |
| CA3186696A1 (en) | 2022-01-27 |
| KR102866823B1 (ko) | 2025-09-30 |
| EP4185583A1 (en) | 2023-05-31 |
| WO2022020747A1 (en) | 2022-01-27 |
| US11447472B2 (en) | 2022-09-20 |
| AU2021314329A1 (en) | 2023-02-23 |
| AU2021314329A8 (en) | 2023-03-09 |
| JP2023535724A (ja) | 2023-08-21 |
| KR20230061354A (ko) | 2023-05-08 |
| WO2022020747A8 (en) | 2023-02-16 |
| US20220024903A1 (en) | 2022-01-27 |
| CN115989229A (zh) | 2023-04-18 |
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