AU2021314329A1 - Polymorophs of 5-aza-4'-thio-2'-deoxycytidine - Google Patents

Polymorophs of 5-aza-4'-thio-2'-deoxycytidine Download PDF

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Publication number
AU2021314329A1
AU2021314329A1 AU2021314329A AU2021314329A AU2021314329A1 AU 2021314329 A1 AU2021314329 A1 AU 2021314329A1 AU 2021314329 A AU2021314329 A AU 2021314329A AU 2021314329 A AU2021314329 A AU 2021314329A AU 2021314329 A1 AU2021314329 A1 AU 2021314329A1
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AU
Australia
Prior art keywords
crystalline polymorph
cancer
aza
days
administering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021314329A
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English (en)
Other versions
AU2021314329A8 (en
Inventor
Hyunyong Cho
Doo Young Jung
Jin Soo Lee
Mark J. Suto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pinotbio Inc
Southern Research Institute
Original Assignee
Pinotbio Inc
Southern Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pinotbio Inc, Southern Research Institute filed Critical Pinotbio Inc
Publication of AU2021314329A1 publication Critical patent/AU2021314329A1/en
Publication of AU2021314329A8 publication Critical patent/AU2021314329A8/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2021314329A 2020-07-23 2021-07-23 Polymorophs of 5-aza-4'-thio-2'-deoxycytidine Pending AU2021314329A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063055754P 2020-07-23 2020-07-23
US63/055,754 2020-07-23
PCT/US2021/043021 WO2022020747A1 (en) 2020-07-23 2021-07-23 Polymorophs of 5-aza-4'-thio-2-deoxycytidine

Publications (2)

Publication Number Publication Date
AU2021314329A1 true AU2021314329A1 (en) 2023-02-23
AU2021314329A8 AU2021314329A8 (en) 2023-03-09

Family

ID=79687860

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021314329A Pending AU2021314329A1 (en) 2020-07-23 2021-07-23 Polymorophs of 5-aza-4'-thio-2'-deoxycytidine

Country Status (10)

Country Link
US (1) US11447472B2 (https=)
EP (1) EP4185583A4 (https=)
JP (1) JP7679452B2 (https=)
KR (1) KR102866823B1 (https=)
CN (1) CN115989229A (https=)
AU (1) AU2021314329A1 (https=)
BR (1) BR112023001236A2 (https=)
CA (1) CA3186696A1 (https=)
MX (1) MX2023000979A (https=)
WO (1) WO2022020747A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230123277A1 (en) * 2021-10-15 2023-04-20 Akirabio, Inc. Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease and thalassemia

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020322A (en) 1993-11-09 2000-02-01 Pro-Neuron, Inc. Acyl deoxyribonucleoside derivatives and uses thereof
US5591722A (en) 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
CN103951583B (zh) * 2006-12-06 2016-01-06 科内图斯医药公司 一种抑制剂的结晶形式
PL3692983T3 (pl) 2008-05-15 2021-12-27 Celgene Corporation Doustne formulacje analogów cytydyny i sposoby ich zastosowania
WO2011109012A1 (en) 2010-03-02 2011-09-09 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
US20110218170A1 (en) 2010-03-02 2011-09-08 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
SG11201610551TA (en) 2014-07-14 2017-01-27 Gilead Sciences Inc Combinations for treating cancers
US20160312261A1 (en) 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
EP3527226A4 (en) 2016-10-17 2020-06-17 Daiichi Sankyo Company, Limited COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR
EP3746452B1 (en) * 2018-02-01 2023-09-13 The United States of America, as represented by the Secretary, Department of Health and Human Services Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides
WO2019204637A1 (en) * 2018-04-19 2019-10-24 Southern Research Institute 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer

Also Published As

Publication number Publication date
MX2023000979A (es) 2023-04-20
JP7679452B2 (ja) 2025-05-19
EP4185583A4 (en) 2024-10-30
CA3186696A1 (en) 2022-01-27
KR102866823B1 (ko) 2025-09-30
EP4185583A1 (en) 2023-05-31
WO2022020747A1 (en) 2022-01-27
US11447472B2 (en) 2022-09-20
AU2021314329A8 (en) 2023-03-09
JP2023535724A (ja) 2023-08-21
KR20230061354A (ko) 2023-05-08
WO2022020747A8 (en) 2023-02-16
BR112023001236A2 (pt) 2023-04-04
US20220024903A1 (en) 2022-01-27
CN115989229A (zh) 2023-04-18

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Free format text: IN VOL 57 , NO 7 , PAGE(S) 1086 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAMES SOUTHERN RESEARCH INSTITUTE; PINOTBIO, INC., APPLICATION NO. 2021314329, UNDER INID (54) CORRECT THE TITLE TO READ POLYMOROPHS OF 5-AZA-4'-THIO-2'-DEOXYCYTIDINE