BR112022024161A2 - Anticorpo multiespecífico, sequência de ácido nucleico, vetor, célula hospedeira, método para produzir o anticorpo multiespecífico e composição farmacêutica - Google Patents
Anticorpo multiespecífico, sequência de ácido nucleico, vetor, célula hospedeira, método para produzir o anticorpo multiespecífico e composição farmacêuticaInfo
- Publication number
- BR112022024161A2 BR112022024161A2 BR112022024161A BR112022024161A BR112022024161A2 BR 112022024161 A2 BR112022024161 A2 BR 112022024161A2 BR 112022024161 A BR112022024161 A BR 112022024161A BR 112022024161 A BR112022024161 A BR 112022024161A BR 112022024161 A2 BR112022024161 A2 BR 112022024161A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- multiespecific
- nucleic acid
- acid sequence
- vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
ANTICORPO MULTIESPECÍFICO, SEQUÊNCIA DE ÁCIDO NUCLEICO, VETOR, CÉLULA HOSPEDEIRA, MÉTODO PARA PRODUZIR O ANTICORPO MULTIESPECÍFICO E COMPOSIÇÃO FARMACÊUTICA. A presente invenção refere-se a um anticorpo multiespecífico compreendendo dois domínios de ligação baseados em anticorpo, que se liga especificamente à mesotelina (MSLN-BD); e pelo menos um domínio de ligação baseado em anticorpo, que se liga especificamente a CD3 (CD3-BD); em que o referido anticorpo multiespecífico não compreende um polipeptídeo da região Fc de imunoglobulina e em que cada um dos referidos MSLN-BD se liga à mesotelina (MSLN) com uma constante de dissociação monovalente (KD) na faixa de 0,5 a 20 nM, quando medida por SPR. A presente invenção refere-se ainda a sequência(s) de ácido nucleico que codifica(m) o referido anticorpo multiespecífico, vetor(es) compreendendo a(s) referida(s) sequência(s) de ácido nucleico, célula(s) hospedeira(s) compreendendo a(s) referida(s) sequência(s) de ácido nucleico ou referido(s) vetor(es), e um método de produção do referido anticorpo multiespecífico. Adicionalmente, a presente invenção refere-se a composições farmacêuticas compreendendo o referido anticorpo multiespecífico e métodos de uso dos mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20177337.1A EP3915580A1 (en) | 2020-05-29 | 2020-05-29 | Multispecific antibody |
PCT/EP2021/064427 WO2021239987A1 (en) | 2020-05-29 | 2021-05-28 | Multispecific antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022024161A2 true BR112022024161A2 (pt) | 2023-02-07 |
Family
ID=84492160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022024161A BR112022024161A2 (pt) | 2020-05-29 | 2021-05-28 | Anticorpo multiespecífico, sequência de ácido nucleico, vetor, célula hospedeira, método para produzir o anticorpo multiespecífico e composição farmacêutica |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230203162A1 (pt) |
EP (1) | EP4157352A1 (pt) |
JP (1) | JP2023526976A (pt) |
KR (1) | KR20230018397A (pt) |
CN (1) | CN116134052A (pt) |
AU (1) | AU2021278317A1 (pt) |
BR (1) | BR112022024161A2 (pt) |
CA (1) | CA3184899A1 (pt) |
IL (1) | IL298076A (pt) |
MX (1) | MX2022014768A (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL271128B1 (en) * | 2017-06-05 | 2024-06-01 | Numab Therapeutics AG | New anti-3CD antibodies |
-
2021
- 2021-05-28 IL IL298076A patent/IL298076A/en unknown
- 2021-05-28 US US18/000,141 patent/US20230203162A1/en active Pending
- 2021-05-28 AU AU2021278317A patent/AU2021278317A1/en active Pending
- 2021-05-28 BR BR112022024161A patent/BR112022024161A2/pt unknown
- 2021-05-28 CA CA3184899A patent/CA3184899A1/en active Pending
- 2021-05-28 EP EP21729866.0A patent/EP4157352A1/en active Pending
- 2021-05-28 JP JP2022571782A patent/JP2023526976A/ja active Pending
- 2021-05-28 KR KR1020227043493A patent/KR20230018397A/ko active Search and Examination
- 2021-05-28 MX MX2022014768A patent/MX2022014768A/es unknown
- 2021-05-28 CN CN202180058995.5A patent/CN116134052A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2022014768A (es) | 2023-01-11 |
EP4157352A1 (en) | 2023-04-05 |
JP2023526976A (ja) | 2023-06-26 |
US20230203162A1 (en) | 2023-06-29 |
IL298076A (en) | 2023-01-01 |
AU2021278317A1 (en) | 2022-12-22 |
CA3184899A1 (en) | 2021-12-02 |
CN116134052A (zh) | 2023-05-16 |
KR20230018397A (ko) | 2023-02-07 |
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